Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.62646752
The synergism between PlGF and VEGF was specific , as PlGF deficiency impaired the response to VEGF , but not to bFGF or histamine . 0.62646752^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.72069937
Besides inducing its own signaling in endothelial cells , PlGF exerts its angiogenic action by synergising with VEGF . 0.72069937^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
A human cDNA coding for a protein related to the vascular permeability factor ( VPF ) was isolated from a term placenta cDNA library ; we therefore named its product placenta growth factor ( PlGF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The presence of mRNAs for vascular endothelial growth factor ( VEGF ) and a VEGF related protein , placenta growth factor ( PIGF ) was examined in 29 cases of renal cell carcinoma tissues and adjacent normal kidney tissues and in 4 human renal cell carcinoma cell lines . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
VEGF receptor subtypes KDR and FLT 1 show different sensitivities to heparin and placenta growth factor . ^^^ Placenta growth factor ( PIGF 1 ) is a recently described growth factor structurally similar to VEGF . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The recently identified placenta growth factor ( PIGF ) is a member of the vascular endothelial growth factor ( VEGF ) family of growth factors . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Placenta growth factor ( PIGF ) , a growth factor significantly related to VEGF , is coexpressed with flt in placenta and human vascular endothelial cells . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Placenta Growth Factor ( PlGF ) was recently discovered as a secreted growth factor for vascular endothelial cells and based on its homology to vascular endothelial growth factor ( VEGF ) , can be classified as a new member of this growth factor family . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
These results were also compared with the sites of expression of VEGF and the related placenta growth factor ( PlGF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The recently identified placenta growth factor gene ( PIGF ) code for a protein related to the vascular permeability factor ( VPF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Placenta growth factor ( PlGF 152 ) , a heparin binding growth factor related to VEGF , was also chemotactic for monocytes at concentrations between 2 . 5 and 25 pmol / L . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Here we show that the Escherichia coli expressed monomers of placenta growth factor ( PLGF ) 129 and vascular endothelial growth factor ( VEGF ) 165 can be re folded in vitro to form PLGF / VEGF heterodimers . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
We have isolated and characterized a novel growth factor for endothelial cells , vascular endothelial growth factor B ( VEGF B ) , with structural similarities to vascular endothelial growth factor ( VEGF ) and placenta growth factor . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
In this study we show that monocytes , in contrast to endothelium , express only the VEGF receptor Flt 1 , and that this receptor specifically binds also the VEGF homolog placenta growth factor ( PlGF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Vascular endothelial growth factor ( VEGF ) and placenta growth factor ( PIGF ) are members of a dimeric growth factor family with angiogenic properties . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
To investigate the molecular mechanisms underlying neovascularization in human germ cell tumors ( GCTs ) , we analysed the expression of two angiogenic growth factors , vascular endothelial growth factor ( VEGF ) and placenta growth factor ( P1GF ) , and of their receptors ( FLT 1 ) and Flk 1 / KDR ) in a panel of testicular tumors . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Assignment of vascular endothelial growth factor ( VEGF ) and placenta growth factor ( PLGF ) genes to human chromosome 6p12 p 21 and 14q24 q 31 regions , respectively . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Placenta Growth Factor ( PIGF ) is a new member of vascular endothelial growth factor ( VEGF ) family . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Breast cancer cell lines and primary human breast tumours express a wide range of vascular growth factors , including VEGF , placenta growth factor , pleiotrophin , TGF beta 1 , acidic and basic FGF , and platelet derived endothelial cell growth factor . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Placenta growth factor ( PlGF ) and vascular endothelial growth factor ( VEGF ) are angiogenic factors containing the 8 cysteine motif of platelet derived growth factor ( PDGF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The assay recognized both VEGF 121 and VEGF 165 isoforms , but had no detectable cross reactivity with platelet derived growth factor or placenta growth factor . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Placenta growth factor ( PlGF ) is a growth factor which belongs to the vascular endothelial growth factor ( VEGF ) family and is known to bind to the fms like tyrosine kinase receptor ( flt 1 ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
To investigate the in vivo angiogenic activity of placenta growth factor ( PIGF ) and its heterodimers with vascular endothelial growth factor ( VEGF ) , the induction of neovascularization of these factors in the mouse cornea was studied . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The binding of VEGF to sFLT 1 ( 3 ) could be competed with placenta growth factor ( PlGF ) , a VEGF related ligand , suggesting that high affinity binding of VEGF and PlGF is mediated by the same or closely related contact sites on sFLT 1 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Little is known of the significance and function of the vascular endothelial growth factor ( VEGF ) family , which includes VEGF , VEGF B , and VEGF C , and of placenta growth factor ( PIGF ) in these processes . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Models of the platelet derived growth factor ( PDGF ) like domains of vascular endothelial growth factor ( VEGF ) and placenta growth factor ( PIGF ) were built based on their homology to PDGF . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
By high throughput sequencing , we have identified a cDNA encoding a polypeptide related to vascular endothelial growth factor ( VEGF ) and placenta growth factor ( PlGF ) in the VEGF / PDGF gene family . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The expression of the angiogenic growth factors , vascular endothelial cell growth factor ( VEGF ) and placenta growth factor ( PIGF ) was demonstrated in isolated human term cytotrophoblast and in vitro differentiated syncytiotrophoblast . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Flt 1 tyrosine kinase , vascular endothelial growth factor ( VEGF ) receptor 1 , binds VEGF and a new VEGF related ligand , placenta growth factor , but KDR / Flk 1 ( VEGF receptor 2 ) binds only VEGF . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Both mutant VEGF , which activates only KDR , and placenta growth factor , which activates only FLT 1 , were able to enhance FLT 1 expression . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Placenta growth factor ( PlGF ) and vascular endothelial growth factor ( VEGF ) represent two closely related angiogenic growth factors active as homodimers or heterodimers . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
In the present study , we have defined the expression of mRNA encoding VEGF B , VEGF C , and placenta growth factor ( PIGF ) , compared with that of VEGF mRNA , in normal ovary and a range of ovarian epithelial tumors . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Placenta growth factor , which binds to Flt 1 / VEGF R 1 but not Flk 1 / KDR / VEGF R 2 receptor tyrosine kinase , failed to increase permeability . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The VEGF related factor , placenta growth factor ( PIGF ) , had little effect on PGI 2 synthesis , arachidonic acid release or cPLA 2 activation . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Vascular endothelial growth factor ( VEGF ) and placenta growth factor ( PIGF ) are structurally related growth factors for endothelial cells . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
It hence is superior to established fractal methods for distinguishing effects induced by various isoforms of vascular endothelial growth factor ( VEGF 121 and VEGF 165 ) , placenta growth factor ( PlGF ) isoforms , and control treatment . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
In contrast , activation of VEGF receptor 1 ( Flt 1 ) by its specific ligand placenta growth factor ( PlGF ) had no effect on the tyrosine phosphorylation of cadherins and catenins . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
These aptamers bind equally well to murine VEGF 164 , do not bind to VEGF 121 or the smaller isoform of placenta growth factor ( PlGF 129 ) , and show reduced , but significant affinity for the VEGF165 / PlGF129 heterodimer . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Akt activation was not detected in response to stimulation with placenta growth factor or an Flt 1 selective VEGF mutant . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
By semi quantitative RT PCR in molar tissue for VEGF and placenta growth factor , a member of VEGF family , neither of the mRNA levels have no relation to the development of persistent trophoblastic disease . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Comparison of expression patterns for placenta growth factor , vascular endothelial growth factor ( VEGF ) , VEGF B and VEGF C in the human placenta throughout gestation . ^^^ In this study we used in situ hybridisation to localise which cells in the placenta expressed mRNA for VEGF , placenta growth factor ( PlGF ) , VEGF B and VEGF C . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The growth was suppressed by Flt 1 IgG 1 chimeric protein and dependent on vascular endothelial growth factor ( VEGF ) but not placenta growth factor ( PIGF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Hypoxia promotes angiogenesis and up regulates vascular endothelial growth factor ( VEGF ) expression while it down regulates placenta growth factor ( PIGF ) that possess 53 % homology with VEGF . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
We also investigated the expression of vascular endothelial growth factor ( VEGF ) , placenta growth factor ( PlGF ) and their receptor FLT 1 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
To study vascular endothelial growth factor ( VEGF ) and placenta growth factor ( PlGF ) concentrations and their possible binders , serum from 22 non pregnant and 55 pregnant women ( 15 at weeks 10 13 ; 40 at term ) , umbilical vein ( n = 24 ) and artery ( n = 13 ) and amniotic fluid ( a pool of 50 at weeks 15 17 ; 11 at term ) were assessed for VEGF and PlGF by an enzyme linked immunosorbent assay . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Osteoclasts predominantly expressed VEGF receptor 1 ( VEGFR 1 ) , and activity of recombinant human placenta growth factor 1 on osteoclast recruitment was comparable to that of rhVEGF , showing that the VEGF signal is mediated through VEGFR 1 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
To investigate which other members of the VEGF family are overexpressed in human brain tumours , the mRNA levels of placenta growth factor ( PlGF ) , VEGF A , and VEGF B genes were determined by northern blot analysis in surgically obtained human meningiomas . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The goal of this investigation was to measure changes in vascular permeability , pore cutoff size , and number of transvascular transport pathways as a function of time and in response to vascular endothelial growth factor ( VEGF ) , placenta growth factor ( PIGF 1 and PIGF 2 ) , or basic fibroblast growth factor ( bFGF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
One mutant ( VEGF 0 ) , which had amino acids 83 89 of VEGF substituted with the analogous region of the related placenta growth factor , demonstrated significantly reduced VEGFR 2 binding compared with wild type VEGF , indicating that this region was required for VEGF VEGFR 2 interaction . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
In this study , we examined the expression of the recently isolated VEGF gene family members ( placenta growth factor ( PlGF ) , VEGF B , and VEGF C ) in human dermal microvascular endothelial cells and bovine retinal pericytes cultured under various oxygen tensions . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Placenta growth factor ( PlGF ) induces vascular endothelial growth factor ( VEGF ) secretion from mononuclear cells and is co expressed with VEGF in synovial fluid . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Both np 2 forms bind VEGF ( 165 ) with high affinity in the presence of heparin ( K ( D ) 1 . 3 10 10 ( 10 ) m ) but not VEGF ( 121 ) . np 2 also binds the heparin binding form of placenta growth factor . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
METHODS : Vascular endothelial growth factor ( VEGF ) , placenta growth factor , hepatocyte growth factor / scatter factor , and basic fibroblast growth factor were quantified in 69 tumors by enzyme linked immunosorbent assay . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Furthermore , we show the time course of total and free sVEGFR 1 release together with its putative ligands , VEGF A and placenta growth factor ( PIGF ) , from macrovascular endothelial cells . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Regulation of placental vascular endothelial growth factor ( VEGF ) and placenta growth factor ( PIGF ) and soluble Flt 1 by oxygen a review . ^^^ We hypothesized that the reported relatively high oxygen level in the intervillous space in contact with IUGR placental villi will limit angiogenesis by changes in vascular endothelial growth factor ( VEGF ) and placenta growth factor ( PIGF ) expression and function . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Placenta growth factor ( PlGF ) is a homodimeric glycoprotein , 46 50 kDa in size , belonging to the vascular endothelial growth factor ( VEGF ) sub family . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Several growth factors , including vascular endothelial growth factor ( VEGF ) , placenta growth factor ( PlGF ) , angiopoietins , and angiostatins are produced within the villi and act locally , via their receptors , to control angiogenesis . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The EDTA soluble matrix fraction contained high concentrations of platelet derived growth factor ( PDGF AB ) , lower concentrations of vascular endothelial growth factor ( VEGF ) , placenta growth factor ( PlGF ) and fibroblast growth factor ( FGF 2 ) , and very low concentrations of epidermal growth factor ( EGF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The aim of this study was to analyse the expression of transcripts and proteins for vascular endothelial growth factor ( VEGF ) and placenta growth factor ( PlGF ) in different compartments of the early conceptus at primary implantation sites during lacunar ( n = 6 ) , early villous ( n = 9 ) and villous placenta ( n = 6 ) stages of gestation in the rhesus monkey . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Over the last few years , several additional members of the VEGF gene family have been identified , including placenta growth factor ( PIGF ) ( Maglione et al . , 1991 , 1993 ) , VEGF B ( Olofsson et al . , 1996 ) , VEGF C ( Joukov et al . , 1996 ; Lee et al . , 1996 ) , and VEGF D ( Orlandini et al . , 1996 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Other ligands that interact differentially with these receptors and that are structurally related to VEGF A include VEGF B , VEGF C , VEGF D , and placenta growth factor ( PLGF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Reverse transcriptase polymerase chain reaction analysis showed the presence of mRNAs encoding at least three different vascular endothelial growth factor isoforms ( VEGF ( 121 ) , VEGF ( 165 ) , and VEGF ( 189 ) ) and transcripts for two placenta growth factor isoforms ( PlGF 1 and PlGF 2 ) in human melanoma cells . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Vascular endothelial growth factors ( VEGF ) , placenta growth factor ( PlGF ) and their receptors VEGFR 1 / Flt 1 , VEGFR 2 / KDR and VEGFR 3 / Flt4 have important roles in vasculogenesis and angiogenesis . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The placenta growth factor ( PlGF 1 : 0 . 1 and 0 . 5 microg ml ( 1 ) or 3 . 4 and 17 nM ) did not increase plasma extravasation , per se , but abolished the effects of VEGF ( 2 . 4 nM ) . 3 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Placenta growth factor ( PlGF ) is a member of the VEGF family of growth factors , but has little or undetectable mitogenic activity on endothelial cells . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
In this study , it is shown that erythroid cells , but not the other mature hematopoietic cells , coexpress 2 angiogenic factors , vascular endothelial growth factor A ( VEGF A ) and placenta growth factor ( PlGF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Here we report that in addition to vascular endothelial growth factor A ( VEGF A ) , human endometrium expresses messenger ribonucleic acids ( mRNAs ) encoding VEGF C , placenta growth factor ( PlGF ) , the angiopoietins , angiopoietin 1 ( Ang 1 ) and Ang 2 , and the receptors VEGFR 3 ( Flt 4 ) , Tie 1 , and Tie 2 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Placenta growth factor , which ligates to the VEGF Flt 1 receptor but not KDR / Flk 1 , failed to prevent Ox LDL toxicity and had no effect on intracellular GSH levels . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Vascular endothelial growth factor ( VEGF ) and placenta growth factor ( PLGF ) are considered to play important roles in angiogenesis and vascular permeability during placental development . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
SMCs migrated significantly in response to VEGF ( 165 ) and VEGF E , whereas Placenta Growth Factor ( PlGF ) induced migration only at higher concentrations . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Here we constructed a recombinant bifunctional diabody that is capable of blocking both Flt 1 and KDR from binding to their ligands , including VEGF and placenta growth factor ( PlGF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The family of vascular endothelial growth factors ( VEGFs ) currently includes VEGF A , B , C , D , E , and placenta growth factor ( PlGF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Neuropilin 1 and 2 ( NP 1 / NP 2 ) are transmembrane receptors that play a role in axonal guidance by binding of class 3 semaphorins , and in angiogenesis by binding of the vascular endothelial growth factor isoform VEGF 165 and placenta growth factor ( PLGF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
To determine the VEGF ( 165 ) and placenta growth factor 2 ( PlGF 2 ) binding sites of NRP 1 , recombinant NRP 1 domains were expressed in mammalian cells as Myc tagged , soluble proteins , and used in co precipitation experiments with 125I VEGF 165 and 125I PlGF 2 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Placenta growth factor ( PlGF ) is a member of the vascular endothelial growth factor ( VEGF ) family , comprising at least five cytokines specifically involved in the regulation of vascular and / or lymphatic endothelium differentiation . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Similarly , VEGF and KDR selective mutant induced more potent vasorelaxation than Flt selective mutant or placenta growth factor that binds Flt 1 only ( P < 0 . 01 ) , and the vasorelaxation to KDR selective mutant was not significantly different at low concentrations but less than that to VEGF at high concentrations . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The authors explored the individual and collective actions of insulin like growth factor 1 ( IGF 1 ) , vascular endothelial growth factor ( VEGF ) , platelet derived growth factor BB ( PDGF BB ) , fibroblast growth factor 2 ( FGF 2 ) and placenta growth factor ( PlGF ) on several parameters that reflect the angiogenic potential of endothelial cells . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Placenta growth factor 1 antagonizes VEGF induced angiogenesis and tumor growth by the formation of functionally inactive PlGF 1 / VEGF heterodimers . ^^^ Whereas the angiogenic property and molecular mechanisms of VEGF have been well studied , the biological function of its related homolog , placenta growth factor ( PlGF ) , is poorly understood . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The role of VEGF R 1 and the factors that interact exclusively with this receptor ( VEGF B and placenta growth factor ) has remained controversial . 2 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The functional role of VEGF release on Mk maturation is indicated by 2 series of observations . ( 1 ) Molecules preventing the VEGF Flt 1 interaction on the precursor membrane ( eg , soluble Flt 1 receptors ) significantly inhibit Mk polyploidization . ( 2 ) Addition of exogenous VEGF or placenta growth factor ( PlGF ) markedly potentiates Mk maturation . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
To elucidate the mechanism underlying this phenomenon , we studied expression of two angiogenic factors , vascular endothelial growth factor ( VEGF ) and placenta growth factor ( PlGF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
On the other hand , introduction of the loop 1 and 3 of VEGF E ( NZ 7 ) to placenta growth factor rescued the biological activities . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Both cell lines also expressed transcripts for VEGF A , B , C and D , as well as for placenta growth factor ( PlGF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
When we focus on the VEGF receptors , recent findings suggest a role of VEGFR 1 as a functional receptor for placenta growth factor ( PlGF ) and vascular endothelial growth factor A ( VEGF ) A in pericytes and vascular smooth muscle cells in vivo rather than in endothelial cells , and strongly suggest involvement of pericytes in early phases of angiogenesis . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Therefore , we used the VEGF homologue placenta growth factor ( PlGF ) , which only binds to VEGFR 1 and VEGF E , which only recognizes VEGFR 2 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The neuropilin 1 ( NRP 1 ) and neuropilin 2 ( NRP 2 ) receptors can bind the class 3 semaphorin subfamily and the heparin binding forms of vascular endothelial growth factor ( VEGF ) and placenta growth factor ( PlGF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Additional VEGF family members such as the heparin binding form of placenta growth factor ( PlGF 2 ) and VEGF B bind to NRP 1 , and it was also shown that both PlGF 2 and VEGF C bind to NRP 2 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Addition of placenta growth factor ( PlGF ) restored PEDF expression in the presence of anti VEGF antibody . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
During the last few years , several members of the VEGF family have been described namely the VEGF A , B , C , D , E and placenta growth factor ( PlGF ) among which VEGF A ( 121 aminoacids ) plays a role of prime importance in angiogenesis . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
We found that erythroid cells produced placenta growth factor ( PlGF ) , an angiogenic growth factor belonging to the vascular endothelial growth factor ( VEGF ) family , and its expression was induced in bone marrow CD34+ progenitor cells in the presence of erythropoietin . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
In the present study , we show that another VEGF family member , placenta growth factor ( PlGF ) , was highly upregulated at all tumor stages in a ras dependent manner . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Angiogenic cytokines such as vascular endothelial growth factor A ( 164 / 165 ) ( VEGF A ( 164 / 165 ) ) and placenta growth factor ( PlGF ) are being considered for therapeutic relief of coronary heart disease and other forms of tissue ischemia caused by atherosclerosis . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
SU 5416 inhibited cell migration of human vascular endothelial cells expressing both Flt 1 and KDR in response to VEGF and also inhibited the cell migration in response to placenta growth factor ( PIGF ) , a specific ligand for Flt 1 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
They belong to the larger family which also includes VEGF , placenta growth factor ( PlGF ) and VEGF B , VEGF C and VEGF D are ligands for the endothelial cell specific tyrosine kinase receptors VEGFR 2 and VEGFR 3 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Although placenta growth factor specific to VEGF receptor 1 had no significant effect on RANK expression , inhibition of downstream signaling molecules of the VEGF receptor 2 ( Flk 1 / KDR ) such as Src , phospholipase C , protein kinase C , and phosphatidylinositol 3 ' kinase suppressed VEGF stimulated RANK expression in HUVECs . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Several growth factors and specific receptors , e . g . vascular endothelial growth factor ( VEGF ) , PlGF ( placenta growth factor ) and the soluble VEGF 1 receptor ( VEGFR 1 ) play essential roles in the process . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Microarray and subsequent Northern blot and semiquantitative reverse transcription PCR analyses revealed both a decrease ( fibroblast growth factor 1 , transforming growth factor beta 1 , platelet derived growth factor alpha , erbB 2 , and c ets 1 , ) and an increase ( placenta growth factor , hypoxia inducible factor alpha , and endoglin ) in expression of angiogenesis related genes in the PANC 1 tumors by anti VEGF treatment . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Placenta growth factor ( PlGF ) , a homodimeric glycoprotein that is homologous to vascular endothelial growth factor ( VEGF ) , is mitogenic to endothelial cells and protects trophoblast from apoptosis . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Both ERK activation and fibronectin secretion appear to be mediated through the VEGF receptor flt 1 , as evidenced by the effects of the flt 1 specific ligand placenta growth factor . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Vascular insufficiency and retinal ischemia precede many proliferative retinopathies and stimulate secretion of various vasoactive growth factors , including vascular endothelial growth factor ( VEGF ) and placenta growth factor ( PlGF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
In accordance , VEGF or the VEGFR agonists VEGF D or placenta growth factor ( P1GF ) did not produce significant effects on glioma cell proliferation or VEGF production . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
We utilize the fact that placenta growth factor ( PlGF ) 1 , a member of the VEGF family lacking detectable angiogenic activity , preferentially forms intracellular heterodimers with VEGF in cells coexpressing both factors . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Placenta growth factor ( PlGF ) belongs to the vascular endothelial growth factor ( VEGF ) family and represents a key regulator of angiogenic events in pathological conditions . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Placenta growth factor ( PlGF ) is a member of the vascular endothelial growth factor ( VEGF ) family of proangiogenic factors and its overexpression has been linked to pathological angiogenesis . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Circulating plasma sE selectin ( sE S ) , sP selectin ( sP S ) , human soluble vascular cell adhesion molecule 1 ( sVCAM 1 ) , and human soluble intercellular adhesion molecule 1 ( sICAM 1 ) and serum levels of human vascular endothelial growth factor ( VEGF ) , angiogenin ( ANG ) , and placenta growth factor ( P / GF ) were measured with ELISAs . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
We hypothesize that VEGF and placenta growth factor ( PlGF ) are dysregulated in preeclampsia due to high levels of sVEGFR 1 , which leads to impaired placental angiogenesis . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
To address this , we explored the effect of oxygen tension on the expression of VEGF , placenta growth factor ( PlGF ) , and their antagonist , soluble fms like tyrosine kinase 1 ( sFlt 1 ) using ELISA and real time PCR in a primary CT cell culture . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Expression of placenta growth factor is regulated by both VEGF and hyperglycaemia via VEGFR 2 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The cumulative concentration ( 12 to 8 log10M ) relaxation curves were established for VEGF , KDR SM , Flt 1 SM , and placenta growth factor ( PlGF ) in the absence or presence of indomethacin ( INDO , 7 microM ) , N nitro L arginine ( L NNA , 300 microM ) , L NNA + oxyhemoglobin ( HbO , 20 microM ) , or INDO + L NNA + HbO . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
After stimulation with growth factors in vitro [ TSH ; epidermal growth factor ( EGF ) , IGF , placenta growth factor , TGF alpha , TGF beta 1 , fibroblast growth factor , platelet derived growth factor , and hepatocyte growth factor ] cells were analyzed for VEGF gene expression by Northern blotting and for VEGF protein by enzyme immunoassay . ^^^ Placenta growth factor and TGF alpha did not induce VEGF production in TSHr positive HTC cells , whereas they did induce VEGF production in TSHr negative HTC cells . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Vascular endothelial growth factor ( VEGF ) and placenta growth factor ( PlGF ) cause vasodilation . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
BACKGROUND : Overexpression of vascular endothelial growth factor ( VEGF ) correlates with vascularity , metastasis , and proliferation in colorectal cancer but the role of its homologue , placenta growth factor ( PlGF ) , is unknown . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Currently , the VEGF family consists of VEGF A , PlGF ( placenta growth factor ) , VEGF B , VEGF C , VEGF D , VEGF E and snake venom VEGF . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
METHOD OF STUDY : In a nested case control study we compared the serum levels of M CSF , VEGF , and placenta growth factor ( PLGF ) in 23 pregnancies with subsequent mild PE without FGR and nine FGR pregnancies without PE with 40 matched controls at 17 , 25 , and 33 weeks of gestation cross sectionally and longitudinally . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Vascular endothelial growth factor ( VEGF ) and its associated molecule , placenta growth factor ( PlGF ) are now known to support normal hematopoiesis , and leukemia cell growth . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
BACKGROUND : Placenta growth factor ( PlGF ) is a member of the vascular endothelial growth factor ( VEGF ) family . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The amounts of vascular endothelial growth factor ( VEGF ) , placenta growth factor ( PlGF ) and their antagonist , soluble fms like tyrosine kinase 1 ( sFlt 1 ) released in CT culture media were measured using ELISA . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The angiogenic factors vascular endothelial growth factor ( VEGF ) and placenta growth factor ( PlGF ) are respectively up and downregulated by hypoxia . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Placenta growth factor ( PlGF ) belongs to the vascular endothelial growth factor ( VEGF ) family , a group of angiogenic factors that are crucial for tumour angiogenesis . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Vascular endothelial growth factor ( VEGF ) , placenta growth factor ( PlGF ) and their receptors ( VEGFR ) have important roles in vascular remodeling . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Objectives To investigate the effects of GM CSF treatment of chronic venous ulcers on lesion vascularization and on the local synthesis of the angiogenic factors vascular endothelial growth factor ( VEGF ) and placenta growth factor ( PlGF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Various angiogenic factors , such as vascular endothelial growth factor ( VEGF ) and an associated molecule , placenta growth factor ( PlGF ) , are thought to be important for normal and malignant hematopoiesis . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Hypoxia ( 1 % O 2 ) up regulated vascular endothelial growth factor A ( VEGF A ) but , unexpectedly , it decreased interleukin 8 ( IL 8 ) and placenta growth factor ( PlGF ) expression . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
VEGF B is closely related to VEGF A and placenta growth factor ( PlGF ) , but unlike VEGF A , which binds to two receptor tyrosine kinases VEGFR 1 ( Flt 1 ) and VEGFR 2 ( Flk 1 / KDR ) , VEGF B and PlGF bind to VEGFR 1 and not VEGFR 2 . ^^^ VEGF B is closely related to VEGF A and placenta growth factor ( PlGF ) , but unlike VEGF A , which binds to two receptor tyrosine kinases VEGFR 1 ( Flt 1 ) and VEGFR 2 ( Flk 1 / KDR ) , VEGF B and PlGF bind to VEGFR 1 and not VEGFR 2 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The VEGF family currently includes VEGF A , B , C , D , E , F and placenta growth factor ( PlGF ) , that bind in a distinct pattern to three structurally related receptor tyrosine kinases , denoted VEGF receptor 1 , 2 , and 3 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
There were significant differences between healthy and diseased subjects in the levels of tissue inhibitor of metalloproteinases 2 ( TIMP 2 ) , tumor necrosis factor beta ( TNF beta ) , growth related oncogene ( GRO ) , interferon inducible protein 10 ( IP 10 ) , angiogenin ( Ang ) , vascular endothelial growth factor ( VEGF ) , insulin like growth factor binding protein 3 ( IGFBP 3 ) , osteoprotegerin ( OPG ) , epidermal growth factor ( EGF ) , glial derived neurotrophic factor ( GDNF ) , pulmonary and activation regulated chemokine ( PARC ) , oncostatin M ( OSM ) , fibroblast growth factor 4 ( FGF 4 ) , IL 16 , homologous to lymphotoxins ( LIGHT ) , and placenta growth factor ( PlGF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Mammalian vascular endothelial growth factors constitute a family of polypeptides , vascular endothelial growth factor ( VEGF ) A , B , C , D and placenta growth factor ( PlGF ) , that regulate blood and lymphatic vessel development . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Placenta growth factor binds only to VEGF receptor 1 ( FLT 1 ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The rat GS 9L glioma cell line produces not only VEGF homodimers but also PlGF homodimers and a novel heterodimer composed of VEGF and PlGF subunits . ^^^ PlGF heterodimers are vascular endothelial cell mitogens nearly as potent as VEGF homodimers . ^^^ However , the existence of not only homodimers but also heterodimers clearly extends the similarity between the VEGF / PlGF and the homologous platelet derived growth factor systems . . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
To consider further the mechanisms underlying these responses , the effect of iodonium compounds was tested on five genes which show oxygen regulated expression ; erythropoietin , vascular endothelial growth factor ( VEGF ) , lactate dehydrogenase A ( LDH A ) , glucose transporter 1 ( GLUT 1 ) and placental growth factor ( PLGF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
We have analyzed the expression of VEGF and its receptors , the related placental growth factor ( PlGF ) and the endothelial receptors FLT 4 and Tie by in situ hybridization in capillary hemangioblastomas and hemangiopericytomas . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Furthermore , transfected cells expressing these chimeric Flt 4 receptors exhibited increased DNA synthesis in response to VEGF or PlGF . ^^^ These results demonstrate that a single Ig like domain is the major determinant for VEGF PlGF interaction and that binding to this domain may initiate a signal transduction cascade . . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
We have studied the effects of VEGF homo and heterodimers , VEGF / PlGF heterodimers , and PlGF and VEGF C homodimers on Day 13 CAM . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Domain 2 residues Arg 159 , Glu 208 and His 223 Arg224 ( together ) affect both VEGF and PlGF binding , while Glu 137 , Lys 171 , His 223 , and Arg 224 affect PlGF but not VEGF . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The binding of 125I PlGF 2 to these receptors was inhibited by an excess of PlGF 2 and by the 165 amino acid form of VEGF ( VEGF 165 ) , but not at all by VEGF 121 and very marginally if at all by PlGF 1 . ^^^ The apparent molecular weight and the binding characteristics of these receptors correspond to those of the recently identified VEGF 165 specific receptor neuropilin 1 , and we therefore conclude that neuropilin 1 is a receptor for PlGF 2 . ^^^ The binding of 125I PlGF 2 as well as the binding of 125I VEGF 165 to these receptors was inhibited by a synthetic peptide derived from exon 6 of PlGF . ^^^ Furthermore , the binding of 125I PlGF 2 , but not that of 125I VEGF 165 , was also inhibited by a synthetic peptide derived from exon 7 of PlGF . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Vascular endothelial growth factor ( VEGF ) plays a major role and we therefore investigated the other members of the VEGF family : Placental growth factor ( PlGF ) , VEGF B , C , and D , and platelet derived growth factors ( PDGF ) A and B . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
OBJECTIVE : To compare serum levels of angiogenic growth factors vascular endothelial growth factor ( VEGF ) , placental growth factor ( PlGF ) and angiogenin in pre eclamptic women and matched controls . ^^^ RESULTS : VEGF and PIGF serum levels were significantly lower in pre eclamptic pregnancies , compared with controls ( VEGF 0 . 31 + / 1 . 20 vs 18 . 30 + / 24 . 97 pg / mL , P = 0 . 0004 ; PlGF 54 . 19 + / 32 . 05 vs 497 . 95 + / 340 . 51 pg / mL , P < 0 . 0001 ) . ^^^ Matched couple analysis showed VEGF serum concentrations to be lower in the majority of pre eclamptic women and PlGF concentrations to be lower in all pre eclamptic women . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The extracellular portion of the VEGF and PlGF receptor , Flt 1 ( or VEGFR 1 ) , consists of seven immunoglobulin like domains . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The stimulating factors of angiogenesis are enumerated : VEGF ( vascular endothelial growth factor ) , PLGF ( placental growth factor ) , IF ( Intherpheron gamma ) , Il 1 , Il 8 ( interleukin 1 , 8 ) , FGF ( fibroblast growth factor ) , acid and basic , TGF ( transforming growth factor ) , PDGF ( platelet derived growth factor ) , GH ( growth hormone ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Role of vascular endothelial growth factor ( VEGF ) and placenta derived growth factor ( PlGF ) in regulating human haemopoietic cell growth . ^^^ Vascular endothelial growth factor ( VEGF ) and placental derived growth factor ( PlGF ) stimulate cell proliferation and differentiation by binding to their specific receptors , Flk 1 / KDR and Flt 1 respectively . ^^^ The aim of this study was to directly evaluate the importance of VEGF , PlGF / Flt 1 and Flk 1 / KDR receptor ligand interactions in regulating normal and malignant human haemopoiesis . ^^^ Addition of VEGF and PlGF failed to enhance survival or cloning efficiency of human haemopoietic progenitors isolated from adult bone marrows , fetal livers or cord blood samples . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The expression of genes of the other angiogenic factors , vascular endothelial growth factor ( VEGF ) , and basic fibroblast growth factor ( bFGF ) was also tested , and compared to that of PlGF . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Both predimerized ( KDR Fc ) and monomeric ( KDR cbu ) receptors were examined with vascular endothelial cell growth factor ( VEGF ) homodimers and VEGF / placental growth factor ( PlGF ) heterodimers . ^^^ In contrast , VEGF / PlGF bound to KDR Fc with ka = 7 . 3 + / 1 . 6e4 , kd = 4 . 4 + / 1 . 2e 4 , and KD = 6 + / 1 . 2 nM . ^^^ We were unable to detect association between VEGF / PlGF and monomeric KDR . ^^^ However , nanomolar concentrations of VEGF / PlGF were able to elicit weak calcium mobilization in endothelial cells . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The overall structure of PlGF 1 is similar to that of vascular endothelial growth factor ( VEGF ) with which it shares 42 % amino acid sequence identity . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Likewise , neither VEGF ( 5 10 10 ( 4 ) to 10 ( 15 ) M ) nor PlGF ( 10 ( 6 ) to 10 ( 8 ) M ) , which selectively binds Flt 1 , served to increase FITC Dextran 40 efflux at Day 5 . 0 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
VEGF C acts only on VEGF R 2 on vascular endothelial cells , whereas placental growth factor 1 ( PlGF 1 ) acts only on VEGF R 1 . ^^^ In the subset of vessels in which VEGF C significantly increased L ( p ) acutely , there was a sustained 12 fold increase in L ( p ) 20 min after perfusion , but this was not seen in those vessels which did not respond acutely to VEGF C , or in vessels exposed to PlGF 1 . ^^^ L ( p ) was also increased 24 h after perfusion with VEGF C , but not with PlGF 1 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The expression , localization and role of the angiogenic growth factors ( FGF , VEGF , PLGF , HGF ) are described and discussed . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
OBJECTIVE : The object of this study was to determine the effect of epithelial growth factor ( EGF ) , vascular endothelial growth factor ( VEGF ) , and placental growth factor ( PlGF ) on the differentiation of first trimester and term cytotrophoblasts . ^^^ Cultured cells were stimulated with EGF , VEGF , or PlGF at 0 . 5 , 5 , and 50 ng / mL , in the presence or absence of N ( G ) nitro L arginine methyl ester hydrochloride ( 10 ( 4 ) M ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
We have shown that HHV 8 transformed endothelial cells ( EC HHV 8 ) express higher levels of VEGF , VEGF C , VEGF D , and PlGF in addition to VEGF receptors 1 , 2 , and 3 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Invasive cytotrophoblasts in early gestation expressed VEGF A , VEGF C , placental growth factor ( PlGF ) , VEGFR 1 , and VEGFR 3 and , at term , VEGF A , PlGF , and VEGFR 1 . ^^^ In vitro the cells incorporated VEGF A into the surrounding extracellular matrix ; PlGF was secreted . ^^^ In severe preeclampsia and hemolysis , elevated liver enzymes , and low platelets syndrome , immunolocalization on tissue sections showed that cytotrophoblast VEGF A and VEGFR 1 staining decreased ; staining for PlGF was unaffected . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Placental expression of VEGF , PlGF and their receptors in a model of placental insufficiency intrauterine growth restriction ( PI IUGR ) . ^^^ Placental development requires adequate and organized interaction of vascular growth factors and their receptors , including vascular endothelial growth factor ( VEGF ) and placental growth factor ( PlGF ) . ^^^ Both VEGF and PlGF , acting through the tyrosine kinase receptors VEGFR 1 and VEGFR 2 , have been implicated in playing a role in ovine placental vascular development . ^^^ Both caruncular and cotyledonary VEGF and PlGF mRNA concentration increased with gestational age ( P < 0 . 05 ) , whereas only cotyledonary VEGF and PlGF protein concentration increased over gestation ( P < 0 . 002 ) . ^^^ At 90 dpc , expression of PlGF and VEGF mRNA was not altered by the HT treatment . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Tumors removed at 1 week intervals up to week 6 were probed by immunohistochemistry ( n = 3 11 samples ) for vascular endothelial growth factor ( VEGF ) , placental growth factor ( PlGF ) , flk 1 and flt 1 , angiopoietin 1 and 2 , and Tie 1 and 2 . ^^^ Tumor extracts were also assayed for VEGF by immunoblot and for PlGF by comparative reverse transcription PCR . ^^^ Antiangiogenic therapy may require a tumor specific combination of inhibitors for PlGF , the angiopoietins , or their receptors , in addition to VEGF / flk 1 . . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The survival factors investigated were bFGF , IGF 1 , PDGF AA , VEGF and PLGF . ^^^ VEGF and PLGF in these experiments had no protective effects against TNF alpha / IFN gamma induced apoptosis . ^^^ VEGF and PLGF did not protect against apoptosis , and the mechanisms of action remain unclear . . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The vascular endothelial growth factor ( VEGF ) related factor , placental growth factor ( PlGF ) , has been shown recently to play an important role in pathological VEGF driven angiogenesis . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Previous studies demonstrated that exogenous administration of placental growth factor ( PlGF ) , a homologue of VEGF , stimulates vascular permeability but the role of endogenous PlGF in plasma extravasation during pathological conditions remains unknown . ^^^ We recently generated PlGF deficient ( PlGF ( / ) ) mice and demonstrated that loss of PlGF impaired pathological angiogenesis by attenuating the response to VEGF . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Here , we report that PlGF stimulated angiogenesis and collateral growth in ischemic heart and limb with at least a comparable efficiency to vascular endothelial growth factor ( VEGF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Placental growth factor ( PlGF ) belongs to the same family as the vascular endothelial growth factor A ( VEGF A ) . ^^^ Mice expressing a truncated form of the specific receptor for PlGF , the VEGF receptor 1 ( VEGFR 1 ) , show impaired angiogenesis similar to that observed in Plgf ( / ) mice . ^^^ These data suggest a pivotal role for PlGF and VEGFR 1 in regulating VEGF A dependent angiogenesis under pathological conditions . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
PURPOSE : Vascular endothelial growth factor ( VEGF ) A and placental growth factor ( PlGF ) are members of a large group of homologous peptides identified as the VEGF family . ^^^ Although VEGF A is known to act as a potent angiogenic peptide in the retina , the vasoactive function of PlGF in this tissue is less well defined . ^^^ Separate groups of neonatal mice were also injected intraperitoneally daily from P 2 through P 9 with either VEGF neutralizing antibody , PlGF neutralizing antibody , isotype immunoglobulin ( Ig ) G , or phosphate buffered saline ( PBS ) . ^^^ RESULTS : Quantitative ( real time ) reverse transcription polymerase chain reaction ( RT PCR ) demonstrated similar expression patterns of VEGF A and PlGF mRNA during neonatal retinal development , although the fluctuation between time periods was greater overall for VEGF A . ^^^ The localization of VEGF A and PlGF in the retina , as revealed by in situ hybridization and immunohistochemistry , was also similar . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Up regulation of placental growth factor ( PlGF ) , a member of the vascular endothelial growth factor ( VEGF ) family , has been found in several conditions associated with pathologic angiogenesis ; however , its distinct role in the control of angiogenesis has remained unclear . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
We have investigated the expression patterns of VEGF , placental growth factor ( PlGF ) , and their receptors fms like tyrosine kinase ( Flt 1 ) and kinase insert domain containing region ( KDR ) in placentas with histopathological changes . ^^^ Positive immunostaining for VEGF , PlGF , and Flt 1 was observed in infiltrated neutrophils and macrophages in the placentas with chorioamnionitis ( CAM ) . ^^^ These findings suggested that in the hypoxic / ischemic regions , VEGF and KDR expression is increased within the villous vessels by paracrine regulation , whereas the expression of PlGF and Flt 1 is enhanced in villous trophoblasts by autocrine regulation . ^^^ Furthermore , the results indicated that VEGF and PlGF stimulate inflammatory cell migration by autocrine regulation via the Flt 1 receptor in the CAM placenta . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Efforts to therapeutically stimulate or inhibit vessel growth have been primarily focused on vascular endothelial growth factor ( VEGF ) and its receptor VEGFR 2 ( Flk 1 ) , while little attention has been devoted to the therapeutic potential for angiogenic disorders of placental growth factor ( PlGF ) , a VEGF family member , and its receptor VEGFR 1 ( Flt 1 ) . ^^^ Indeed , PlGF stimulated angiogenesis and collateral growth in ischemic heart and limb with at least a comparable efficiency to VEGF and did not cause side effects associated with VEGF , such as edema or hypotension . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Here , we confirm that placental soluble fms like tyrosine kinase 1 ( sFlt 1 ) , an antagonist of VEGF and placental growth factor ( PlGF ) , is upregulated in preeclampsia , leading to increased systemic levels of sFlt 1 that fall after delivery . ^^^ We demonstrate that increased circulating sFlt 1 in patients with preeclampsia is associated with decreased circulating levels of free VEGF and PlGF , resulting in endothelial dysfunction in vitro that can be rescued by exogenous VEGF and PlGF . ^^^ Additionally , VEGF and PlGF cause microvascular relaxation of rat renal arterioles in vitro that is blocked by sFlt 1 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Pericyte coverage and density of microvessels remained stable in the tumor that expressed neither PlGF nor VEGF after treatment . ^^^ Hemoglobin content of PlGF containing Matrigel implants was 5 . 7 fold that of anti PlGF / anti VEGF treated controls ( Day 6 , p < 0 . 03 ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Circulating levels of vascular endothelial growth factor ( VEGF ) are increased in women with pre eclampsia , while circulating placental growth factor ( PlGF ) levels are decreased . ^^^ In first trimester and term trophoblast cells the presence of VEGF ( 121 , 165 and 189 ) and PlGF ( 132 and 152 ) mRNA were demonstrated in both groups by reverse transcription polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Placental growth factor ( PlGF ) competes with vascular endothelial growth factor ( VEGF ) for binding to VEGF receptor ( VEGFR ) 1 but does not bind VEGFR 2 . ^^^ Experiments show that PlGF can augment the response to VEGF in pathological angiogenesis and in models of endothelial cell survival , migration , and proliferation . ^^^ This synergy has been hypothesized to be due to a combination of the following : signaling by PlGF through VEGFR 1 and displacement of VEGF from VEGFR 1 to VEGFR 2 by PlGF , causing increased signaling through VEGFR 2 . ^^^ In this study , the relative contribution of PlGF induced VEGF displacement to the synergy is quantified using a mathematical model of ligand receptor binding to examine the effect on ligand receptor complex formation of VEGF and PlGF acting together . ^^^ Parameters specific to the VEGF PlGF system are used based on existing data . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The relationship between transplacental O 2 diffusion and placental expression of PlGF , VEGF and their receptors in a placental insufficiency model of fetal growth restriction . ^^^ Placental growth factor ( PlGF ) and vascular endothelial growth factor ( VEGF ) are involved in placental angiogenesis through interactions with the VEGFR 1 and VEGFR 2 receptors . ^^^ Maternal caruncle PlGF mRNA was increased in FGR ( P < 0 . 02 ) , while fetal cotyledon VEGF mRNA was reduced ( P < 0 . 02 ) . ^^^ Immunoblot analysis of PlGF and VEGF demonstrated single bands at 19 , 000 and 18 , 600 Mr , respectively . ^^^ Caruncle PlGF concentration was increased ( P < 0 . 04 ) , while cotyledon VEGF was decreased ( P < 0 . 05 ) in FGR placentae . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Adequate and organized interaction of vascular endothelial growth factors ( VEGF ) , placenta growth factors ( PlGF ) , and their receptors are essential for a normal development and function of the placenta . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
In the current study , the influence of placental growth factor ( PlGF ) , a member of the VEGF family , in human and experimental choroidal neovascularization ( CNV ) was investigated . ^^^ The spatial and temporal pattern of VEGF isoforms and PlGF mRNA expression were explored by using the laser capture catapulting technique and RT PCR in a murine laser induced model and in vitro . ^^^ RESULTS : Human neovascular membranes consistently expressed VEGF A , B , and C ; PlGF ; and VEGFR 1 and 2 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Survival mechanisms of VEGF and PlGF during microvascular remodeling . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
In contrast to VEGF and its receptor VEGFR 2 , PlGF and its receptor VEGFR 1 have been largely neglected and therefore their potential for therapy has not been previously explored . ^^^ In this review , we describe the molecular properties of PlGF and VEGFR 1 and how this translates into an important role for PlGF in the angiogenic switch in pathological angiogenesis , by interacting with VEGFR 1 and synergizing with VEGF . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
BACKGROUND : To determine the plasma concentrations of placental growth factor ( PLGF ) , vascular endothelial growth factor ( VEGF ) , transforming growth factor beta 1 ( TGF beta 1 ) , soluble tumor necrosis factor alpha receptor ( sTNFp 55 ) , interleukin 2 receptor ( IL 2R ) , and interleukins 6 and 10 ( IL 6 , IL 10 ) in normotensive and preeclamptic women , and to evaluate the correlations between these cytokines and the diastolic blood pressure and fibronectin levels . ^^^ Peripheral venous blood samples were obtained and plasma levels of PLGF , VEGF , TGF beta 1 , sTNFp 55 , IL 2R , IL 6 and IL 10 were measured by an enzyme linked immunoassay and fibronectin by a radial immundiffusion technic . ^^^ RESULTS : In preeclampsia PLGF and VEGF levels were significantly lower , and TGF beta 1 , sTNFp 55 , IL 2R , IL 6 and IL 10 levels were significantly higher than in normotensive pregnancy ( p < 0 . 001 ) . ^^^ The plasma levels of PLGF and VEGF significantly decreased , whereas TGF beta 1 , sTNFp 55 , IL 2R , IL 6 and IL 10 levels significantly increased with the increments in diastolic blood pressure and fibronectin levels ( p < 0 . 001 ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
We have previously shown that vascular endothelial growth factor ( VEGF ) increases the random movement of trophoblast cells although placental growth factor ( PlGF ) has no effect . ^^^ We hypothesized that VEGF but not PlGF would be chemotactic for trophoblast cells . ^^^ VEGF ( 1 , 10 and 100 ng / ml+ / 1 microg / ml heparin or + / 100 microM L NAME ) and PlGF ( 1 , 10 , 100 ng / ml ) were tested . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Role of PlGF in the intra and intermolecular cross talk between the VEGF receptors Flt 1 and Flk 1 . ^^^ Here we report that placental growth factor ( PGF , also known as PlGF ) regulates inter and intramolecular cross talk between the VEGF RTKs Flt 1 and Flk 1 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The vascular endothelial growth factor ( VEGF ) family member placental growth factor ( PlGF ) was found as an early regulated gene whose induction was already detected after 2 h treatment with BMP 2 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
VEGF and PlGF : two pleiotropic growth factors with distinct roles in development and homeostasis . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
OBJECTIVE : To evaluate the role of vascular endothelial growth factor ( VEGF ) and placental growth factor ( PlGF ) in adhesion formation after laparoscopic surgery . ^^^ ANIMAL ( S ) : Female wild type mice and transgenic mice ( n = 110 ) , expressing exclusively VEGF A ( 164 ) ( VEGF A ( 164 / 164 ) ) or deficient for VEGF B ( VEGF B ( / ) ) or for PlGF ( PlGF ( / ) ) . ^^^ In comparison with wild type mice , basal adhesions were higher in VEGF A ( 164 / 164 ) mice and similar in VEGF B ( / ) and PlGF ( / ) mice . ^^^ Absence of pneumoperitoneum enhanced adhesions in VEGF A ( 164 / 164 ) , VEGF B ( / ) , and PlGF ( / ) mice indicates up regulation of VEGF A ( 164 ) , VEGF B , and PlGF by CO ( 2 ) pneumoperitoneum as a mechanism for pneumoperitoneum enhanced adhesion formation . . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
We will give evidence that matrix metallo proteinase 9 mediated Kit ligand ( Stem cell factor ) processing is essential for cell mobilization induced by chemo / cytokines , like vascular endothelial growth factor ( VEGF ) , Placental growth factor ( PlGF ) , stromal cell derived factor 1 ( SDF 1 ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Several growth factors such as vascular endothelial growth factor ( VEGF ) A and placental growth factor ( PlGF ) are involved in the placental vascular development . ^^^ The mRNA levels of VEGF A , PlGF , and their receptors were quantified in placentas and placental beds . ^^^ Levels of VEGF A , PlGF , and soluble VEGF receptor ( VEGFR ) were assessed in maternal plasma . ^^^ Preeclampsia was associated with low levels of circulating PlGF and increased levels of total VEGF A and soluble VEGFR 1 . ^^^ Immunohistochemical studies revealed that VEGF A and PlGF were localized in trophoblastic cells . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
In general , the angiogenic process is initiated by growth factors such as bFGF , VEGF , or placental growth factor ( PlGF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Here , we used cells with inducible expression of BF 2 , combined with microarray analysis , to identify Placental Growth Factor ( PlGF ) , a Vascular Endothelial Growth Factor ( VEGF ) family member previously implicated in angiogenesis , as a downstream target of BF 2 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Placental growth factor ( PlGF ) is a member of the vascular endothelial growth factor ( VEGF ) family that binds specifically to Flt 1 . ^^^ In human umbilical vein endothelial cells , VEGF and PlGF induced expression of both full length FosB mRNA and an alternatively spliced variant , DeltaFosB , with similar efficacy and kinetics . ^^^ In contrast , PlGF induced c Fos expression less strongly than VEGF , and whereas VEGF strongly upregulated tissue factor mRNA , PlGF had a negligible effect . ^^^ These findings show for the first time that VEGF and PlGF induce mRNA expression of the transcription factors FosB and c Fos , and suggest that these factors may play a role in the biological responses mediated by PlGF and Flt 1 . . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
This period is characterized by high placental levels of VEGF but moderate PlGF expression . ^^^ Beginning at about week 25 in the newly formed peripheral villi , angiogenesis switches from branching to non branching and this period is accompanied by a steep drop in VEGF and a slower decline in PlGF expression . ^^^ The possible interactions between ( a ) . the biphasic development of intraplacental oxygen tensions , ( b ) . changes in VEGF and PlGF levels and ( c ) . developing vascular geometry are discussed . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
We assessed the relationship between clinical features of renal cell cancer ( RCC ) and PlGF levels in relation to VEGF . ^^^ MATERIALS AND METHODS : Plasma PlGF and VEGF levels were measured in patients with renal cell cancer . ^^^ RESULTS : PlGF and VEGF levels in patients with RCC were significantly higher than those in non cancer controls . ^^^ PlGF levels were significantly associated with histological grade and total tumor vascularity ( TTV ) , and VEGF levels were significantly associated with T , M stage , histological grade , venous invasion and TTV . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The release of vascular endothelial growth factor ( VEGF ) , basic fibroblast growth factor ( bFGF ) , placental growth factor ( PlGF ) , and monocyte chemoattractant protein 1 ( MCP 1 ) was demonstrated by analysis of MSC conditioned media ( MSC CM ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Placental growth factor ( PlGF ) is a member of the vascular endothelial growth factor ( VEGF ) family and plays an important role in pathological angiogenic events . ^^^ Here we report the crystal structure of PlGF bound to the second immunoglobulin like domain of VEGFR 1 at 2 . 5 A resolution and compare the complex to the closely related structure of VEGF bound to the same receptor domain . ^^^ The two growth factors , PlGF and VEGF , share a sequence identity of approximately 50 % . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
We now provide evidence that MT 1 MMP overexpression specifically affected VEGF A production and failed to influence that of other VEGF family members ( VEGF , B , C , D , or PlGF ) or their receptors . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Some of these factors have been shown to influence trophoblast vascular endothelial growth factor ( VEGF ) / PlGF expression suggesting this particular family of angiogenic proteins play an important role in placental angiogenesis . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Inhibition by flk 1 kinase inhibitor SU 1498 and failure of placental growth factor ( PlGF ) to up regulate DAF confirmed the role of VEGF R 2 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The expression of both VEGF receptor 1 ( VEGFR 1 ) and VEGFR 2 was upregulated both in the satellite cells of the damaged muscles and during myotube formation in vitro ; the VEGF effect was mediated by the VEGFR 2 , since the transfer of PlGF , a VEGF family member interacting with the VEGFR 1 , was ineffective . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Bioinformatic analysis of primary endothelial cell gene array data illustrated by the analysis of transcriptome changes in endothelial cells exposed to VEGF A and PlGF . ^^^ We illustrate these principles by analysis of a previously unpublished set of gene array data in which human umbilical vein endothelial cells ( HUVEC ) cultured in either rich or low serum media were exposed to vascular endothelial growth factor ( VEGF ) A 165 or placental growth factor ( PlGF ) 1 ( 131 ) . ^^^ In contrast to some previous studies , we found that VEGF A and PlGF consistently regulated only small , non overlapping and culture media dependant sets of HUVEC transcripts , despite causing significant cell biological changes . . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Limited data suggest that excess circulating soluble fms like tyrosine kinase 1 ( sFlt 1 ) , which binds placental growth factor ( PlGF ) and vascular endothelial growth factor ( VEGF ) , may have a pathogenic role . ^^^ Serum concentrations of angiogenic factors ( total sFlt 1 , free PlGF , and free VEGF ) were measured throughout pregnancy ; there were a total of 655 serum specimens . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
VEGF 165 and VEGF E , both interacting with VEGFR 2 , but not PlGF exclusively stimulating VEGFR 1 , induce within minutes internalization of uPAR via an LDL receptor like molecule , dependent on generation of active uPA and the presence of plasminogen activator inhibitor 1 ( PAI 1 ) . uPAR seems to play a pivotal role in VEGFR 2 induced endothelial cell migration because cleavage of surface uPAR impaired the migratory response of endothelial cells toward VEGF E , but not toward PlGF . . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : Using KG 1 ( VEGFR 1+ / VEGFR 2+ ) and HL 60 ( VEGFR 1+ ) cells with differential VEGF receptor display , we investigated ligand induced clonogenic response and receptor initiated signaling after stimulation with VEGF A , the VEGFR 1 selective ligand placental growth factor ( PlGF ) , or receptor specific antibody agonists . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Pre eclampsia is accompanied by high circulating levels of soluble VEGF receptor 1 , which forms inactive complexes with VEGF and placental growth factor ( PlGF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
TC productions of sFlt 1 , VEGF , and PlGF were measured by enzyme linked immunosorbent assay ( ELISA ) . ^^^ Messenger RNA expressions of Flt 1 , VEGF and PlGF were determined by RT PCR . ^^^ We also found that under hypoxia condition : ( 1 ) the ratio of PlGF / VEGF production was reversed ; ( 2 ) the ratio of lipid peroxides to superoxide dismutase production was increased . ^^^ The increased mRNA expressions for Flt 1 and VEGF and the decreased mRNA expression for PlGF in TCs were consistent with the protein productions under hypoxia condition . ^^^ CONCLUSION : We concluded that upregulation of sFlt 1 and unbalanced PlGF / VEGF production associated with increased oxidative stress are consequences of hypoxia in placental TCs . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Vascular endothelial growth factor ( VEGF ) and placental growth factor ( PlGF ) are key angiogenic stimulators during normal development and wound healing , as well as in a variety of pathological conditions . ^^^ Recent studies have demonstrated a synergistic effect of VEGF and PlGF in pathological angiogenesis and suggest a role for PlGF in amplifying VEGF action in endothelial cells . ^^^ In cultured human retinal and umbilical vein endothelial cells , VEGF induced the production of PlGF protein by over 10 fold ( P < 0 . 01 ) in a dose dependent manner through a post transcriptional mechanism . ^^^ The increased PlGF expression upon VEGF treatment was significantly reduced by inhibition of the protein kinase C ( PKC ) and MEK signaling pathways , as well as by treatment with the calcium ionophore A 23187 . ^^^ Taken together , our findings demonstrate that VEGF can amplify its effects on endothelial cells by inducing the production of PlGF via a post transcriptional mechanism in a PKC dependent manner , and provide a potential link between PKC inhibition and amelioration of vascular complications in the development of angiogenic diseases . . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The anti Flt 1 peptide shows specificity toward binding to VEGFR 1 and it inhibits binding of VEGF , placental growth factor ( PlGF ) , and VEGF / PlGF heterodimer to VEGFR 1 . ^^^ This peptide does not inhibit the proliferation of endothelial cells induced by VEGF and VEGF / PlGF heterodimer but it effectively blocks VEGF induced migration of endothelial cells and their capacity to form capillary like structures on fibrin gel based in vitro angiogenesis system . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Animal models with mutations in the genes coding for placental growth factor ( PlGF ) , a member of vascular endothelial growth factor ( VEGF ) family , or the tyrosine kinase domain of the PlGF receptor ( Flt 1 ) have revealed differences between normal physiological angiogenesis and pathological angiogenesis associated with conditions such as tumor growth , arthritis and atherosclerosis . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The discovery of the vascular endothelial growth factor ( VEGF ) family members VEGF , VEGF B , placental growth factor ( PlGF ) , VEGF C and VEGF D and their receptors VEGFR 1 , 2 and 3 has provided tools for studying the vascular system in development as well as in diseases ranging from ischemic heart disease to cancer . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Pretreatment with L NNA completely inhibited VEGF and PlGF vasodilation and prevented the increase in cGMP seen with both agonists . ^^^ VEGF vasorelaxation may not only occur through binding to VEGFR 2 , since PlGF , the specific VEGFR 1 agonist , also causes vasodilation . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
ELISA for human sFlt 1 , vascular endothelial growth factor ( VEGF ) and placental growth factor ( PlGF ) were performed . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the relationship of neonatal platelet count and preeclampsia to levels of soluble fms like tyrosine kinase 1 ( sFlt 1 ) , placental growth factor ( PlGF ) , and vascular endothelial growth factor ( VEGF ) in the cord blood of preterm infants . ^^^ METHODS : Sixty nine preterm infants with a gestational age between 26 and 37 weeks at birth were enrolled . sFlt 1 , PlGF , and VEGF levels in the cord blood of preterm neonates , with or without maternal preeclampsia , were measured using a standardized sandwich enzyme linked immunosorbent assay method . ^^^ RESULTS : Infants with maternal preeclampsia had higher cord blood sFlt 1 but lower PlGF and VEGF levels . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
We measured VEGF A , PlGF , SCF , MMP 9 , EDB+ fibronectin , sVEGFR 2 , sVEGFR 1 , salphaVbeta 3 , sTie 2 , IL 8 and CRP in the blood of 22 healthy volunteers , 17 early breast , 17 early colorectal , and 8 advanced sarcoma / melanoma cancer patients . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Recent studies have suggested that excess secretion of a naturally occurring anti angiogenic molecule of placental origin referred to as soluble fms like tyrosine kinase 1 ( sFlt 1 , also referred to as sVEGFR 1 ) may contribute to the pathogenesis of preeclampsia . sFlt 1 acts by antagonizing two pro angiogenic molecules vascular endothelial growth factor ( VEGF ) and placental growth factor ( PlGF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Redundant roles of VEGF B and PlGF during selective VEGF A blockade in mice . ^^^ VEGF B and placental growth factor ( PlGF ) activate VEGFR 1 selectively , however , mice lacking either ligand display only minor developmental defects . ^^^ We hypothesized that the relative contributions of VEGF B and PlGF to VEGFR 1 signaling may be masked in the presence of VEGF A , which is abundantly expressed during postnatal development . ^^^ To test this hypothesis , neonatal or adult mice were treated with a monoclonal antibody ( G 6 23 IgG ) blocking murine VEGF A or a soluble VEGFR 1 receptor IgG chimeric construct [ mFlt ( 1 3 ) IgG ] , which neutralizes VEGF A , VEGF B , and PlGF . ^^^ In conclusion , our findings suggest that PlGF and VEGF B do not compensate during conditions of VEGF A blockade , suggesting a minor role for compensatory VEGFR 1 signaling during postnatal development and vascular homeostasis in adults . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
We reveal that vascular endothelial growth factor receptor 1 ( FLT 1 ) modulates acute leukemia distribution within the BM , along VEGF and PlGF gradients , regulating leukemia survival and exit into the peripheral circulation . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
OBJECTIVE : Serum levels of soluble fms like tyrosine kinase 1 ( sFlt 1 ) , vascular endothelial growth factor ( VEGF ) , and placental growth factor ( PlGF ) are altered in women with clinical preeclampsia . ^^^ STUDY DESIGN : Free urinary levels of sFlt 1 , VEGF , and PlGF were measured by immunoassay in 68 women enrolled prospectively in the following groups : nonpregnant reproductive age ( NP CTR n = 14 ) , healthy pregnant control ( P CTR n = 16 ) , pregnant hypertensive and proteinuric women who did not meet criteria for severe preeclampsia ( pHTN n = 21 ) , and women with sPE ( n = 17 ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Serum levels of vascular endothelial growth factor ( VEGF ) , soluble Flt 1 and Flk 1 receptors , placental growth factor ( PlGF ) , angiopoietin 2 ( Ang 2 ) and soluble Tie 2 receptor were determined by ELISA . ^^^ Interestingly , in CHC patients serum levels of VEGF and Tie 2 correlated with grade of inflammation , PlGF correlated with stage of fibrosis , and Flt 1 and Flk 1 correlated with serum transaminase levels ( p < 0 . 05 in all cases ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Placental growth factor ( PlGF ) is a member of the vascular endothelial growth factor ( VEGF ) family that binds specifically to VEGF receptor ( VEGFR ) 1 . ^^^ However , the mechanism of PlGF and VEGFR 1 mediated angiogenesis has remained unclear and some in vitro studies suggest that VEGF A / VEGFR 2 signaling may also play a role in PlGF mediated angiogenesis . ^^^ We conclude that adenovirus mediated PlGF 2 gene transfer to vascular tissue increases endogenous VEGF A expression and produces significant angiogenesis . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
This response is dependent upon the expression of vascular endothelial growth factor ( VEGF ) receptor 1 ( VEGFR 1 ) , which mediates cell migration in response to VEGF or placental growth factor ( PLGF ) . ^^^ In this study , we found that exposure of cultured mouse bone marrow derived mesenchymal stromal cells ( MSC ) to hypoxia or an adenovirus encoding a constitutively active form of hypoxia inducible factor 1 ( HIF 1 ) induced VEGFR 1 mRNA and protein expression and promoted ex vivo migration in response to VEGF or PLGF . ^^^ MSC in which HIF 1 activity was inhibited by a dominant negative or RNA interference approach expressed markedly reduced levels of VEGFR 1 and failed to migrate or activate AKT in response to VEGF or PLGF . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
VEGF was the principal mediator of angiogenic actions of U87MG conditioned media ( CM ) , since VEGF neutralizing antibody completely inhibited U87MG induced angiogenic responses and no detectable levels of IGF , bFGF , and PlGF were found in U87MG CM . ^^^ IGFBP 4 also antagonized angiogenic effects of VEGF ( 165 ) , PlGF , and bFGF , and reduced U87MG colony formation in soft agar . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Our results demonstrate that the deletion of these two genes , Plgf , which acts in synergism with VEGF , and eNos , a downstream mediator of VEGF , determines a significant change in the vascular response to an ischemic stimulus and that oxidative stress within the ischemic tissue represents a crucial factor to maintain tissue homeostasis . . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Previous studies indicated that the VEGF homolog placental growth factor ( PlGF ) has a more significant role in disease than in health . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Tumors overexpressing PlGF exhibited higher levels of PlGF homodimers and PlGF / vascular endothelial growth factor ( VEGF ) heterodimers but decreased levels of VEGF homodimers . ^^^ Our study shows that PlGF overexpression decreases VEGF homodimer formation and inhibits tumor progression . . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
VEGFA ( VEGF ) , VEGFB , VEGFC , VEGFD ( FIGF ) and PGF ( PlGF ) are VEGF family ligands for receptor tyrosine kinases , including VEGFR 1 ( FLT 1 ) , VEGFR 2 ( KDR ) and VEGFR 3 ( FLT 4 ) . ^^^ VEGFA ( VEGF ) , VEGFB , VEGFC , VEGFD ( FIGF ) and PGF ( PlGF ) are VEGF family ligands for receptor tyrosine kinases , including VEGFR 1 ( FLT 1 ) , VEGFR 2 ( KDR ) and VEGFR 3 ( FLT 4 ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
In this study , we show that sepsis is associated with a time dependent increase in circulating levels of vascular endothelial growth factor ( VEGF ) and placental growth factor ( PlGF ) in animal and human models of sepsis . ^^^ Adenovirus mediated overexpression of soluble Flt 1 ( sFlt 1 ) in a mouse model of endotoxemia attenuated the rise in VEGF and PlGF levels and blocked the effect of endotoxemia on cardiac function , vascular permeability , and mortality . ^^^ Adenovirus mediated overexpression of VEGF but not PlGF exacerbated the lipopolysaccharide mediated toxic effects . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization . ^^^ Our data suggest local VEGF and / or PlGF expression promote vasculogenesis ; VEGF plays a role in EPC recruitment and subsequent formation of functional vessels . . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Chimeric VEGF E ( NZ 7 ) / PlGF promotes angiogenesis via VEGFR 2 without significant enhancement of vascular permeability and inflammation . ^^^ To design a novel angiogenic factor without severe side effects , we examined the biological function of chimeric VEGF E ( NZ 7 ) / placental growth factor ( PlGF ) , which is composed of Orf Virus ( NZ 7 ) derived VEGF E ( NZ 7 ) and human PlGF 1 , in a transgenic ( Tg ) mouse model . ^^^ METHODS AND RESULTS : A strong angiogenic response was observed in both VEGF E ( NZ 7 ) / PlGF and VEGF A 165 Tg mice . ^^^ Notably , the vascular leakage of VEGF E ( NZ 7 ) / PlGF induced blood vessels was 4 fold lower than that of VEGF A 165 induced blood vessels . ^^^ Furthermore , the monocyte / macrophage recruitment in the skin of VEGF E ( NZ 7 ) / PlGF Tg mice was approximately 8 fold decreased compared with that of VEGF A 165 Tg mice . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
VEGF transcripts were also detected in trophoblastic giant cells raising the possibility that these cells may secrete heterodimers consisting of one PIGF subunit and one VEGF subunit . ^^^ The secretion of PIGF and VEGF by trophoblastic giant cells is likely to be the signal which initiates and co ordinates vascularization in the deciduum and placenta during early embryogenesis . . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The aim of this study was to determine if placental growth factor ( PIGF ) , a recently identified member of the VEGF family , was expressed in diabetic eyes undergoing preretinal neovascularization . ^^^ Rabbit anti PIGF antiserum was raised using a 20 amino acid N terminal sequence to PIGF and did not cross react with VEGF 165 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
OBJECTIVES : This study examined whether atorvastatin increases plasma levels of soluble Fms like tyrosine kinase 1 ( sFlt 1 ) and reciprocally decreases vascular endothelial growth factor ( VEGF ) and placental growth factor ( PlGF ) levels in patients with acute myocardial infarction ( AMI ) . ^^^ By capturing VEGF and PlGF in plasma , sFlt 1 acts as a natural inhibitor of VEGF and PlGF , which have proinflammatory properties . ^^^ METHODS : Left ventriculography and enzyme linked immunosorbent assay of plasma levels of sFlt 1 , VEGF , and PlGF were repeated after AMI in 50 consecutive patients with a first AMI . ^^^ RESULTS : The sFlt 1 levels were low in the acute phase , followed by an increase at 2 weeks after AMI , whereas free VEGF and PlGF levels were high in the acute phase , followed by a decrease at 2 weeks . ^^^ Atorvastatin increased sFlt 1 levels and reciprocally decreased VEGF and PlGF levels at 6 months compared with placebo . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Plasma VEGF ( 165 ) and PlGF concentrations were higher in group 1 than in groups 0 and 2 ( VEGF ( 165 ) 75 pg / ml , range 24 to 105 , vs 23 pg / ml , range 15 to 29 , and 19 pg / ml , range 10 to 41 , respectively , F = 5 . 53 , p = 0 . 006 ; PlGF 35 pg / ml , range 3 . 5 to 105 , vs 1 pg / ml , range 1 to 38 , and 1 pg / ml , range 1 to 5 , respectively , F = 7 . 09 , p = 0 . 008 ) . ^^^ Plasma VEGF ( 165 ) and PlGF levels were similar in groups 0 and 2 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
VEGF A is the prototype member of a gene family that includes also PlGF , VEGF B , VEGF C , VEGF D and the orf virus encoded VEGF E . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The expression of VEGF , the closely related placental growth factor ( PIGF ) , the newly cloned endothelial high affinity VEGF receptors KDR and FLT 1 , and the endothelial orphan receptors FLT 4 and Tie were analyzed by in situ hybridization in normal human brain tissue and in the following CNS tumors : gliomas , grades 2 , 3 , 4 ; meningiomas , grades 1 and 2 ; and melanoma metastases to the cerebrum . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
To identify the factors involved , normoxic P 30 cerebral slices were cultured with growth factors that are either hypoxia inducible ( e . g . , PDGF BB , erythropoietin , and VEGF ) and / or are known to act on endothelial cells ( e . g . , PDGF BB , VEGF , and PIGF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Potentiation of the malignant phenotype of ARO cells by bcl 2 was not ascribed to altered expression of ( 1 ) cytokine / growth factors ( IL 4 , IL 6 , IL 8 , IL 10 , IL 12 , TGF alpha , TGF beta ) , ( 2 ) thyroid specific transcripts ( TG , TPO , TSH R , PIGF , PAX 8 ) or ( 3 ) genes influencing tumor aggressiveness [ VEGF , HMGI ( Y ) , HMGI C ] . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
PIGF and vascular endothelial growth factor ( VEGF ) are both angiogenic factors belonging to the platelet derived growth factor ( PDGF ) family . ^^^ PIGF is a dimeric glycoprotein which shares a number of biochemical and functional features with VEGF . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
The diverse functions of VEGF and its homologues ( PIGF , VEGF B , VEGF C , VEGF D , and VEGF E ) can be explained by their differential binding to the three signaling VEGF receptors . ^^^ The VEGF family members PIGF and VEGF B with exclusive binding capacities to the VEGFR 1 can influence monocyte activation and differentiation . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
We have studied the production of proangiogenic ( VEGF , FGF 2 , PIGF and PDGF ) and antiangiogenic ( TSP 1 ) factors in two p 73 overexpressing clones obtained from the human ovarian carcinoma cells A 2780 . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
On the other hand , this PGF ( 2alpha ) analog induced expression of luteal VEGF mRNA . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Basic fibroblast growth factor ( bFGF or FGF 2 ) , vascular endothelial growth factor ( VEGF ) , and endothelin 1 ( ET 1 ) are peptide growth factors ( PGF ) mediating normal lung development , maturation , injury , and repair . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
In the present study , changes in angiogenesis and vascular expression of endothelial growth factor ( VEGF ) were evaluated throughout the luteal phase and after PGF ( 2alpha ) induced luteolysis . ^^^ However , immunostaining for VEGF protein was high in late luteal regression ( day 17 ) and 36 h after PGF ( 2alpha ) administration . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Inhibition of VEGFR 2 blocked activation of extracellular regulated kinase , p 38 , Akt , and endothelial nitric oxide synthetase ( eNOS ) by VEGF , but did not inhibit p 38 activation by the VEGFR 1 specific ligand , placental growth factor ( PIGF ) . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Key cytokines driving angiogenesis include vascular endothelial growth factor ( VEGF ) family members / receptors ( placental growth factor [ PIGF ] , VEGF A , and VEGF C ) and angiopoietins . ^^^ Expression of PIGF , VEGF A , VEGF C , and Ang 1 was localized by in situ hybridization . ^^^ PIGF expression occurred only in vascular anomalies predicted to involute or actively involuting , a pattern potentially linked to PIGF function as a conditional antagonist of VEGF A . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
In this study we investigated by RT PCR if the growth factors PGF , PDGF A , PDGF B , VEGF A , VEGF B , VEGF C , VEGF D , ANG 1 , ANG 2 , ANG 3 and ANG 4 are expressed in granulosa cells . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
There are nine proteins in the immediate VEGF family : VEGFA , VEGFB , VEGFC , VEGFD , VEGF 3 , placental growth factor ( PGF ) , VEGF receptor ( VEGFR ) 1 , VEGFR 2 , and VEGFR 1 related . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Several cytokines , interleukins ( IL ) , and growth factors , including ENA 78 , GM CSF , GRO , IL 1beta , IL 6 , IL 8 , MCP 1 , OSM , VEGF , FGF 4 , FGF 7 , FGF 9 , GCP 2 , IGFBP 1 , IGFBP 2 , IGFBP 3 , IGFBP 4 , IP 10 , LIF , MIF , MIP 3alpha , osteoprotegerin , PARC , PIGF , TGF beta 2 , TGF beta 3 , TIMP 1 , as well as TIMP 2 , were secreted by CB MSCs , while IL 4 , IL 5 , IL 7 , IL 13 , TGF beta 1 , TNF alpha , and TNF beta were not expressed under normal growth conditions . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
OBJECTIVE : We investigated whether human chorionic gonadotropin ( hCG ) or local factors , including chemical hypoxia , IGF 1 and IGF 2 , prostaglandin ( PG ) E ( 2 ) , and PGF ( 2alpha ) prevail in modulating VEGF mRNA and protein production in human midluteal phase luteal cells . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
In the present study , we investigated the effects of minodronate , a newly developed bisphosphonate , on PGF ( 2alpha ) induced VEGF synthesis in MC3T3 E 1 cells . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
To dissect the signals of these two receptors , we generated transgenic mice overexpressing either the VEGFR 2 specific ligand VEGF E ( NZ 7 ) or VEGFR 1 specific ligand PlGF 2 under the control of the Keratin 14 promoter . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
Cell homogenates were incubated with Trans Signal Angiogenesis Antibody Array containing antibodies to angiogenic activators ( ANG , HGF , leptin , VEGF , IL 6 , IL 8 , PIGF , FGF alpha / beta , TNF alpha and TGF alpha ) and inhibitors ( IFN gamma , IL 12 , IP 10 , TIMP 1 and 2 ) . ^^^ Hcy decreased the expression of leptin , IL 6 , 8 , PIGF , FGF alpha and VEGF , while the levels of anti angiogenic IL 12 , IP 10 ( chemokine ) and TIMP 1 were increased by Hcy . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
OBJECTIVE : Accumulating evidence suggests that the balance between vascular endothelial growth factor ( VEGF ) , placental growth factor ( PIGF ) , and their receptors is important for effective vasculogenesis , angiogenesis , and placental development . ^^^ Recently , the soluble form of VEGFR 1 ( sVEGFR 1 ) , an antagonist to VEGF and PIGF , has been implicated in the pathophysiology of pre eclampsia . ^^^
Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
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Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
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Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
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Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
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Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
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Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
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Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
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Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
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Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
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Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
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Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
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Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
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Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
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Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
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Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
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Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
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Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
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Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
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Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
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Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
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Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
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Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
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Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
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Interacting proteins: P49763 and P15692	Pubmed	SVM Score :0.0
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