Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
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Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
C / EBP delta is also present in mammary epithelial cells , whereas C / EBP alpha is not detectable . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
In contrast , overexpression of C / EBP beta or C / EBP delta had no effect on hepatoma cell growth . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Rapid communication : nucleotide sequence of bovine C / EBP delta gene . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
In contrast to the LPS response , C / EBP delta was unchanged . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Supershift analysis revealed upregulated DNA binding activity of C / EBP beta but not C / EBP delta . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
The steady state levels of C / EBP beta and a new isoform , C / EBP delta , were dramatically increased in many tissues within 4 h following LPS treatment . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Using Western blotting and immunohistochemical staining , we have determined the temporal order of expression for C / EBP alpha , C / EBP beta , and C / EBP delta in differentiating myelomonocytic marrow cells . ^^^ While we have detected C / EBP alpha , C / EBP beta , and C / EBP delta in multiple myeloid leukemia cell lines , and C / EBP alpha in normal myeloid cells and in de novo human myeloid leukemias , we have not detected these C / EBP isoforms in either erythroid or lymphoid cells . ^^^ Finally , we show that C / EBP alpha , C / EBP beta , and C / EBP delta protein and messenger RNA levels correlate in maturing granulocytic cells . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
The proteins encoded by these C / EBP related genes , termed C / EBP beta and C / EBP delta , exhibit similar DNA binding specificities and affinities compared with C / EBP alpha . ^^^ Furthermore , C / EBP beta and C / EBP delta readily form heterodimers with one another as well as with C / EBP alpha . ^^^ The transcriptional activating capacity of these two newly identified C / EBP isoforms was demonstrated by transient transfection experiments in which expression vectors encoding C / EBP beta and C / EBP delta were observed to induce transcription from the promoter of the serum albumin gene in cultured hepatoma cells . ^^^ The mRNAs encoding C / EBP beta and C / EBP delta were detected in a number of tissues , most of which corresponded to sites of expression of C / EBP alpha . ^^^ The expression pattern of C / EBP beta and C / EBP delta during adipose conversion of 3T3 L 1 cells was examined by Western and Northern blotting assays . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
The genetic program undertaken during the clonal expansion phase of 3T3 L 1 differentiation , controlled in part by C / EBP beta and C / EBP delta , is less clearly understood . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Increased expression of C / EBP delta was observed first in the liver on day 1 after GalN administration and in the pancreas at 4 weeks after initiating CuD . ^^^ We suggest that C / EBP delta could be involved in the initial activation of epithelial progenitor cells and that HNF 3 alpha , beta , and gamma , and C / EBP beta might participate in their maturation . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
An antibody specific for the C / EBP related protein , C / EBP delta , detected C / EBP delta as part of a nuclear protein complex bound to the inverted CCAAT sequence of the CFTR gene . ^^^ Also , the detection of specific activating transcription factor / cyclic AMP response element binding protein antigens by antibody supershift analysis of nuclear complexes suggest that species of this family of transcription factors could be involved in the formation of complexes with C / EBP delta within the CFTR gene inverted CCAAT like element . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
In this study , we demonstrate that the involved inducible C / EBP isoforms are C / EBP beta and C / EBP delta , and together they control the high level induction of the alpha 1 acid glycoprotein gene in response to inflammatory signals . ^^^ We observed that dephosphorylation severely inhibits the DNA binding ability of C / EBP delta and its transactivating potential increases in the presence of cellular phosphatase inhibitors , such as okadaic acid and sodium orthovanadate . ^^^ These results suggest that C / EBP delta is regulated by phosphorylation . ^^^ Transient transfections using expression vectors of C / EBP alpha , C / EBP beta and C / EBP delta have shown that while individually all three isoforms can transactivate the alpha 1 acid glycoprotein chloramphenicol acetyltransferase gene transcription , co expression of C / EBP alpha and C / EBP beta isoforms results in lower levels of reporter gene expression than the levels predicted from their additive transactivation level . ^^^ Higher than additive levels of reporter gene expression are observed when combinations of C / EBP delta and C / EBP beta or C / EBP delta and C / EBP alpha are used . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
In the absence of new protein synthesis DEX activates the gene encoding C / EBP delta . ^^^ During the early phase of differentiation , high levels of C / EBP delta and C / EBP beta accumulate . ^^^ Here we provide evidence that C / EBP delta and C / EBP beta play early catalytic roles in the differentiation pathway , relaying the effects of the hormonal stimulants DEX and MIX in a cascade like fashion , leading to the activation of the gene encoding C / EBP alpha . ^^^ Conditions facilitating the precocious expression of either C / EBP delta or C / EBP beta were observed to accelerate adipogenesis and , in the case of C / EBP beta , relieve dependence on the early hormonal stimulants . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
We show that in addition to the antioxidant enzyme manganese superoxide dismutase , expression of a variety of stress responsive genes including heme oxygenase 1 , c fos , c jun , CAAT enhancer binding protein ( C / EBP ) beta , and C / EBP delta were increased after hyperoxia . ^^^ Increased c fos , c jun , C / EBP beta , and C / EBP delta mRNA expression was correlated with increased DNA binding activity of the transcription factor complexes activator protein 1 and C / EBP in tissue lysates . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Gel mobility shift and transient expression analyses showed that C / EBP beta and C / EBP isoforms , C / EBP alpha and C / EBP delta , bind to the PISII element and trans activate rnCGM 3 gene expression . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Members of the C / EBP alpha and C / EBP beta , but not C / EBP delta , family are able to bind to these two sites . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
The two C / EBP isoforms , IL 6DBP / NF IL 6 and C / EBP delta / NF IL 6 beta , are induced by IL 6 to promote acute phase gene transcription via different mechanisms . ^^^ We show here that a different C / EBP related factor , C / EBP delta / NF IL 6 beta , is the major IL 6 induced protein interacting with IL 6REs in the nuclei of Hep3B cells . ^^^ In contrast to IL 6DBP / NF IL 6 , whose activity in Hep3B cells is modulated by IL 6 via a post translational mechanism , C / EBP delta / NF IL 6 beta is transcriptionally induced by IL 6 . ^^^ Another contrasting feature is that the C / EBP delta cDNA transfected in Hep3B cells activates transcription from an IL 6RE synthetic promoter in a constitutive manner which is not further enhanced by IL 6 . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Early responses of trans activating factors to growth hormone in preadipocytes : differential regulation of CCAAT enhancer binding protein beta ( C / EBP beta ) and C / EBP delta . ^^^ Concomitant with the translationally activated increase in C / EBP beta , a GH dependent increase was observed in C / EBP delta transcription . ^^^ This was accompanied by an increase in mRNA for C / EBP delta , which was superinduced by cycloheximide and , unlike the increase in C / EBP beta protein , was not observed with insulin . ^^^ Thus GH exerts its effects on C / EBP isoforms at two levels : transcriptional activation of C / EBP delta and translational activation of C / EBP beta . ^^^ It is proposed that GH dependent phosphorylation results in the efficient translation of 40 C / EBP beta and 23 C / EBP beta ( the mouse homolog of the inhibitor liver enriched inhibitory protein ) , and that together with the induction of C / EBP delta , these may be involved in initiating the adipocyte differentiation program . . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
We have examined its expression during the acute phase response ( APR ) and have shown that like C / EBP beta and C / EBP delta , GADD 153 mRNA is markedly induced in livers of rats treated with lipopolysaccharide to initiate the APR . ^^^ Interestingly , its induction is temporally delayed relative to that of C / EBP beta and C / EBP delta but is similar to that of acute phase reactants shown to be regulated by C / EBPs . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
The two ccaat enhancer binding protein isoforms , IL 6DBP and C / EBP delta , are induced by interleukin 6 to promote gene transcription in hepatocytes via different mechanisms . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
While insulin induced expression of C / EBP beta and C / EBP delta within 1 h and caused a > 20 fold increase by 4 h , expression returned to nearly pretreatment levels by 24 h . ^^^ Gel shift analysis revealed that 6 h of insulin treatment decreased the binding of nuclear C / EBP alpha while increasing binding of nuclear C / EBP beta and C / EBP delta . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Nuclear expression of the 36 kilodalton C / EBP delta protein increases immediately after birth , followed first by increases in the 38 kilodalton C / EBP beta protein expression and then by increases in the 42 kilodalton C / EBP alpha protein expression . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
IGF 1 induced C / EBP alpha but decreased C / EBP delta , this might indicate that both transcription factors play a reciprocal role in the expression of the tissue specific UCP gene . . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
C / EBP alpha , C / EBP beta , and C / EBP delta were capable of interacting with elements A and B . ^^^ Under noninduced conditions , C / EBP alpha was the major binding factor ; however , upon cytokine stimulation C / EBP beta and C / EBP delta binding activities were dramatically increased and became the predominant binding factors . ^^^ Consistent with these binding studies were the cotransfection experiments in which C / EBP beta and C / EBP delta were shown to be potent transactivators for the SAA 3 promoter . ^^^ Interestingly , although element C did not interact with C / EBP directly , it was nevertheless required for maximum transactivation by C / EBP delta . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
This suggests that GH acts directly at the nucleus , and one possible target for this action is a rapid increase in transcription of C / EBP delta seen in 3T3 F442A cells in response to GH . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Within 30 min of glucocorticoid treatment , the cellular level of C / EBP delta rises dramatically , increasing > 100 fold within 6 h . ^^^ The reciprocal effects of dexamethasone on the steady state levels of C / EBP alpha and C / EBP delta can be accounted for kinetically and quantitatively by changes in their mRNA levels and by the transcription rates of their respective genes . ^^^ Within 4 h of administration of dexamethasone or triamcinolone acetonide to adult rats , expression of C / EBP delta is induced in white adipose tissue while expression of C / EBP alpha is repressed . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Neonatal mouse liver expresses C / EBP alpha , C / EBP beta and C / EBP delta mRNAs . ^^^ In contrast neonatal mouse brain expresses high levels of C / EBP delta , but little C / EBP alpha or C / EBP beta mRNA . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Other members of this family of bZIP transcription factors , C / EBP alpha and C / EBP delta , were not able to transactivate the P 1 promoter . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Serum amyloid A gene expression under acute phase conditions involves participation of inducible C / EBP beta and C / EBP delta and their activation by phosphorylation . ^^^ In this study , using antibodies against three C / EBP isoforms in DNA binding and Western blot ( immunoblot ) assays , we found that in response to inflammatory signals , both C / EBP delta and C / EBP beta are induced and that their interactions with the SAA promoter element are necessary for the increased SAA gene expression . ^^^ Cotransfections of liver cells with an SAA promoter linked reporter chloramphenicol acetyltransferase gene and murine sarcoma virus expressed C / EBP delta or C / EBP beta confirm such phenomena . ^^^ The increased transactivating ability in the presence of the cellular phosphatase inhibitors okadaic acid and sodium orthovanadate , coupled with the observation that dephosphorylation severely inhibits the DNA binding ability in vitro , implicates a role of phosphorylation in the regulation of the activities of the C / EBP delta isoform . ^^^ Consistent with these findings , we have detected higher levels of DNA binding activity of C / EBP delta prepared from cells treated with phosphatase inhibitors . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Anti C / EBP beta ( NFIL 6 ) and anti C / EBP delta ( NFIL 6 beta ) Abs identified both of these proteins in complexes formed between the NFIL 6 like element and mononuclear cell nuclear extracts . ^^^ C / EBP delta ( NFIL 6 beta ) was not detected in complexes utilizing extracts from the IL 1 nonproducing T cell line . ^^^ These data are consistent with the requirement for C / EBP beta ( NFIL 6 ) and C / EBP delta ( NFIL 6 beta ) in the activation of murine IL 1 beta gene expression by endotoxin . . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Cotransfection experiments in Hep3B cells revealed that mostly HNF 4 , C / EBP alpha , C / EBP delta , and , to a lesser extent , COUP TF stimulated transcription driven by the 125 / +39 region . ^^^ In the non Tf expressing HeLa cells , the Tf promoter could be activated by C / EBP delta . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
C / EBP alpha , beta , and delta interacted with the B box sequence ; however , upon IL 6 stimulation , C / EBP delta binding activity was dramatically induced and became the predominant factor binding to this site . ^^^ Consistent with these binding studies were the cotransfection experiments , revealing that C / EBP delta was the most potent transactivator under induced conditions and that its transactivation on the T 1 kininogen promoter required an intact B box . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
The human C / EBP delta ( CRP3 / CELF ) gene : structure and chromosomal localization . ^^^ In an attempt to identify C / EBP like transcription factors expressed in the prostate , a cDNA homologous to the mouse C / EBP delta ( CRP 3 ) and the rat CELF gene was isolated . ^^^ A genomic clone containing the entire C / EBP delta gene was isolated using a cDNA fragment as a probe . ^^^ By fluorescence in situ hybridization , using the biotinylated genomic clone as a probe , the C / EBP delta gene was assigned to the pericentromeric region of human chromosome 8 , most probably to 8q11 . ^^^ This chromosomal localization was confirmed by analysis of a panel of human 10 hamster somatic cell hybrid DNA samples with a C / EBP delta specific STS . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
The C / EBP family consist of several related proteins , C / EBP alpha , C / EBP beta , C / EBP gamma , and C / EBP delta , that form homodimers and that form heterodimers with each other . ^^^ NF kappa B p 65 , p 50 , and Rel functionally synergize with C / EBP alpha , C / EBP beta , and C / EBP delta . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Using monospecific antibodies we demonstrate that three isoforms of the CCAAT / enhancer binding protein ( C / EBP ) family , namely C / EBP alpha , C / EBP beta , and C / EBP delta , bind to the APRE . ^^^ C / EBP delta does not play a role in this reaction . ^^^ Finally , functional analyses indicate that C / EBP alpha , C / EBP beta , and C / EBP delta are strong transcriptional trans activators of the AGP APRE in hepatoma cells . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
To assess whether these factors might be involved in the hepatocyte proliferation program , we have studied the expression of the three C / EBP isoforms C / EBP alpha , C / EBP beta , and C / EBP delta and the two hepatocyte enriched transcription factors , HNF 1 and HNF 4 , in rat liver at various time points after partial hepatectomy and sham operations using transcriptional `` run on ' ' assays and Northern blot and Western blot experiments . ^^^ In particular , C / EBP alpha expression is rapidly down regulated , whereas C / EBP delta is induced . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Participation of the transcription factor C / EBP delta in the acute phase regulation of the human gene for complement component C 3 . ^^^ Antibodies directed against C / EBP delta supershifted the major IL 1 inducible complexes . ^^^ Western immunoblot analyses showed that the level of C / EBP delta protein was increased dramatically in the nuclei of Hep 3B2 cells after 4 h of IL 1 treatment . ^^^ When Hep 3B2 cells were cotransfected with a C / EBP delta expression vector and a construct with a C 3 promoter and a reporter gene , C / EBP delta was able to trans activate the C 3 promoter in an IL 1 responsive manner . ^^^ The data strongly suggest that C / EBP delta is the major protein responsible for regulating the acute phase expression of the human C 3 gene . . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
The related C / EBP beta and C / EBP delta proteins are not detectable by sensitive immunocytochemical methods in epithelial cells distributed along the duodenal to colonic axis . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Mouse chromosomal location of the CCAAT / enhancer binding proteins C / EBP beta ( Cebpb ) , C / EBP delta ( Cebpd ) , and CRP 1 ( Cebpe ) . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Immunofluorescence studies show cytoplasmic and nuclear localization for C / EBP alpha , in contrast to a restricted nuclear localization for both C / EBP beta and C / EBP delta . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Vasoactive intestinal peptide , pituitary adenylate cyclase activating peptide , and noradrenaline induce the transcription factors CCAAT / enhancer binding protein ( C / EBP ) beta and C / EBP delta in mouse cortical astrocytes : involvement in cAMP regulated glycogen metabolism . ^^^ We report in this study that in these cells , C / EBP beta and C / EBP delta are induced by VIP , PACAP , or NA via the cAMP second messenger pathway . ^^^ Thus , c / ebp beta and c / ebp delta behave as cAMP inducible immediate early genes in astrocytes . ^^^ Moreover , transfection of astrocytes with expression vectors selectively producing the transcriptionally active form of C / EBP beta , termed liver enriched transcriptional activator protein , or C / EBP delta enhance the glycogen resynthesis elicited by NA , whereas an expression vector producing the transcriptionally inactive form of C / EBP beta , termed liver enriched transcriptional inhibitory protein , reduces this resynthesis . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
C / EBP delta mRNA levels increase gradually while C / EBP delta protein levels show variations during post natal development . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
In contrast , C / EBP alpha binding continued to be greatly reduced and no C / EBP delta binding was observed . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
These mutations abolished the binding of rat liver nuclear activities as well as transcription factors C / EBP alpha , C / EBP beta , and C / EBP delta expressed in COS 1 cell lysates to element D . ^^^ Finally , cotransfection experiments of NHE 1 0 . 25 kb promoter chloramphenicol acetyltransferase ( CAT ) construct and C / EBP expression vectors showed that C / EBP alpha and C / EBP delta are transactivators of the NHE 1 proximal promoter in Hep G 2 and VSM A7r5 cells . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
To date , we have only found evidence for involvement of C / EBP alpha , although further experiments will be needed to exclude the role of C / EBP beta and C / EBP delta in receptor gene expression . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Unexpectedly , a significant activation of 3xNF kappaBCAT was also seen upon its co transfection with the expression vector for CCAAT box enhancer binding protein alpha ( C / EBP alpha ) ( but not C / EBP beta or C / EBP delta ) . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Analysis of mRNA for three isoforms of the CCAAT / enhancer binding protein ( C / EBP ) revealed that TCDD ( 5 nM ) selectively inhibited the induction of C / EBP alpha mRNA but did not block the induction of C / EBP beta and C / EBP delta in response to differentiation inducers . ^^^ Immunoblot analysis with specific antibodies to each C / EBP isoform demonstrated that the levels of C / EBP delta and C / EBP beta protein were rapidly induced ( by day 1 ) and then abrogated by day 4 and 8 , respectively , in solvent treated ( control ) cells . ^^^ In TCDD treated cells , however , the levels of C / EBP beta and C / EBP delta protein persisted at these time points . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Effect of thermal injury on the expression of transcription factors that regulate acute phase response genes : the response of C / EBP alpha , C / EBP beta , and C / EBP delta to thermal injury . ^^^ Northern blot hybridization was performed with 32P labeled C / EBP alpha , C / EBP beta , and C / EBP delta cDNAs . ^^^ A simultaneous decrease in C / EBP alpha and an increase in C / EBP beta and C / EBP delta mRNA levels occur in response to thermal injury . ^^^ The responses of C / EBP alpha , C / EBP beta , and C / EBP delta are similar in Buffalo , Sprague Dawley , and Fischer rats . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Within 5 10 min after treatment with any of these agents , nuclear concentrations of C / EBP beta and C / EBP delta double and remain 2 4 fold greater than control cultures for 30 min ( p < 0 . 01 ) . ^^^ Consistent with these results , gel mobility shift assays demonstrate 3 fold increased nuclear C / EBP beta and C / EBP delta DNA binding activity in TNF alpha treated cells , and immunocytochemistry confirms rapid redistribution of these C / EBP isoforms into the nucleus . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
The magnitude of the induction was strikingly higher for C / EBP delta in adrenalectomized animals , indicating a suppressive effect of corticosteroids in the IL 1 beta regulatory pathway . ^^^ Differently , the induction of C / EBP delta was not as pronounced as that of the corresponding mRNA in IL 1 beta treated ADX rats . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Nuclear factor kappa B ( NF kappa B ) , nuclear factor interleukin 6 ( NFIL 6 or C / EBP beta ) and nuclear factor interleukin 6 beta ( NFIL 6 beta or C / EBP delta ) are not sufficient to activate the endogenous interleukin 6 gene in the human breast carcinoma cell line MCF 7 . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Induction of hemopexin , alpha 1 acid glycoprotein , alpha 2 macroglobulin , GADD 153 , C / EBP beta , and C / EBP delta mRNAs by LPS were all abolished in dexamethasone treated rats . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Finally , transfection experiments , in which NF kappa B subunits , NFIL 6 , and NFIL 6 beta ( C / EBP delta ) , were overexpressed in cells transfected with mutated IL 6 enhancer elements linked to a reporter gene show that interaction between members of the two families of factors is required for activation of the IL 6 gene in the absence of the NFIL 6 binding site . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
CCAAT / enhancer binding protein delta ( C / EBP delta ) is induced in growth arrested mouse mammary epithelial cells . ^^^ C / EBP delta gene expression is induced in COMMA D cells arrested in G 0 by serum and growth factor withdrawal or contact inhibition . ^^^ C / EBP delta mRNA , nuclear protein content , and DNA binding activity increase during G 0 growth arrest and decrease after cell cycle induction in COMMA D cells . ^^^ Growth arrest is markedly delayed in COMMA D cells expressing a C / EBP delta antisense construct . ^^^ In contrast to COMMA D cells , C / EBP beta and C / EBP delta mRNA levels remain relatively constant in growth arrested and cell cycle induced NIH3T3 cells . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
CCAAT enhancer binding protein delta ( C / EBP delta ) is a transcriptional nuclear factor , and belongs to basic region leucine zipper class DNA binding proteins . ^^^ One genomic clone containing a 12 kb sequence of the C / EBP delta gene was isolated from a rat genomic library , and a 2 , 056 bp fragment containing the 5 ' flanking region was characterized . ^^^ The 5 ' deletion analysis of this fragment revealed that the sequence spanning 235 through 82 , which was designated as an upstream control element ( UCE ) , remarkably increased a basal promoter activity of the C / EBP delta gene , and was also able to act as a promoter by itself . ^^^ Interestingly , the UCE specifically increased the promoter activity of the rat alpha actin gene suggesting that the C / EBP delta gene may be positively controlled by the UCE via a cell type or promoter type specific manner . . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
The CCAAT / enhancer binding protein delta ( C / EBP delta ) transcription factor is known to be rarely expressed but sharply induced at an early stage of the acute phase response . ^^^ To investigate the regulation mechanisms for this induction , the 5 ' flanking region of the rat C / EBP delta gene was isolated . ^^^ When HepG 2 cells were treated with interleukin 6 ( IL 6 ) , C / EBP delta mRNA was rapidly induced . ^^^ These findings strongly indicate that C / EBP delta gene expression is mediated by APRF / STAT3 , which is phosphorylated for the activation through the IL 6 receptor when cells are treated with IL 6 , and trans activates the other acute phase response genes . . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
An antibody that specifically recognizes C / EBP delta partially supershifted C ' BP 1 / MRE c ' complex , suggesting that C ' BP 1 is identical to C / EBP delta or is closely related to C / EBP delta . . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
C / EBP beta , C / EBP alpha , and C / EBP delta , which bind to element C , prevented the inhibition of promoter activity . ^^^ C / EBP beta , C / EBP alpha , and C / EBP delta , which bind to element C , prevented the inhibition of promoter activity . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Both C / EBP alpha and C / EBP delta expression vectors activated transcription from a PPAR gamma 2 promoter / luciferase expression vector by 5 6 fold in UMR 106 cells . ^^^ Mutation of the two C / EBP DNA recognition elements at 340 bp and 327 bp within the PPAR gamma 2 promoter reduced the inductive effects of both C / EBP alpha and C / EBP delta . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
The NF IL 6 like complex contains subunit C / EBP beta ( NF IL 6alpha ) as one of its components , but apparently not C / EBP alpha or C / EBP delta ( NF IL 6beta ) . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
C / EBP delta mRNA content is low throughout pregnancy and lactation , but increases dramatically ( > 100 fold ) within 12 hours after the onset of postlactational involution . ^^^ In situ hybridization demonstrates that mammary epithelial cells are responsible for the expression of C / EBP delta mRNA during involution . ^^^ In contrast to mammary gland , C / EBP alpha is the predominate isoform expressed in liver with relatively low expression of C / EBP beta and C / EBP delta mRNA . ^^^ The pronounced sequential induction of C / EBP delta and C / EBP beta during postlactational involution is consistent with a role for C / EBPs in the regulation of mammary epithelial cell apoptosis . . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
CCAAT / enhancer binding protein delta ( C / EBP delta ) transcription factor is sharply induced at the early stage of the acute phase response . ^^^ We previously reported that the C / EBP delta gene expression is induced by the acute phase response factor / signal transducers and activators of transcription 3 ( APRF / STAT3 ) . ^^^ However , the expression level of the C / EBP delta gene is relatively high up to several hours after the stimulation , whereas APRF / STAT3 is inactivated within one hour . ^^^ In this report , we identified the two C / EBP delta binding sites at the downstream region of this gene . ^^^ The binding analysis revealed that both of these sites bound recombinant C / EBP delta protein . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Thus , expression of HNF3gamma , C / EBP alpha , and C / EBP beta may be necessary for hepatocytes to acquire highly differentiated functions in addition to coexpression of certain amounts of transcripts of HNF1alpha , HNF1beta , HNF3alpha , HNF3beta , and HNF 4 as well as suppression of C / EBP delta . . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Since C / EBP beta deficient mice have been reported to be largely normal in their expression of proinflammatory cytokines , it is likely that the lack of C / EBP beta is compensated for by the induction of C / EBP delta upon LPS treatment . . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
C / EBP delta reactive products were found in postnatal tissues however , their molecular weights were lower than that found in fetal pig liver . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
C / EBP beta , C / EBP delta and ADD 1 / SREBP 1 are active early during the differentiation process and induce the expression and / or activity of the peroxisome proliferator activated receptor gamma ( PPAR gamma ) , the pivotal coordinator of the adipocyte differentiation process . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
In addition , C / EBP beta and C / EBP delta , but not C / EBP alpha , bind specifically to the C / EBP site of SAA 2 in response to IL 6 stimulation . ^^^ Transient co transfection analysis indicates that co operative association of NF kappa B p 65 with C / EBP beta and , in particular , with C / EBP delta , results in synergistic transcriptional activation of the SAA 2 promoter . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
After 24 hours , cultures were either stained for the AD 3 antigen ( a marker for preadipocytes ) , C / EBP alpha ( a terminal differentiation marker ) , or C / EBP delta ( an early preadipocyte marker ) . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Regulation of LPS mediated induction of C / EBP delta gene expression in livers of young and aged mice . ^^^ We have examined expression of the C / EBP delta gene during the bacterial lipopolysaccharide mediated induction of the acute phase response in livers of young ( 4 months ) and aged ( 24 28 months ) male C57B1 / 6 mice by Northern , Western , and Southwestern analyses . ^^^ C / EBP delta mRNA is present at a low constitutive level , is induced by lipopolysaccharide , and reaches the same induced level in young and aged mice . ^^^ C / EBP delta mRNA is observable 30 min after lipopolysaccharide in total RNA , cytoplasmic and polysomal fractions . ^^^ Specific full length 28 kDa nascent peptides are detectable in polysomes 90 min after lipopolysaccharide . mRNA and nascent peptides cosediment with large polysomes and C / EBP delta mRNA is shifted to larger polysomes in lipopolysaccharide treated aged mice , consistent with an increased rate of initiation . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Compared to cultures from intact fetuses , proportions of C / EBP delta reactive cells ( approximately 40 % ) were increased similarly in cultures from untreated and HC treated hypox fetuses . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
DNA protein binding studies by competition in electromobility shift and supershift assays revealed that 2 members , C / EBP beta and C / EBP delta , are mainly responsible for DNA protein complex formation ; the former acts as a transcriptional repressor and the latter as an activator of the PDGF alphaR gene , respectively . ^^^ Western or Northern blot analyses supported evidence for high expression of C / EBP delta seen only in SHR derived VSMCs . ^^^ Furthermore , forced expression of C / EBP delta transactivated the transcriptional efficiency of the PDGF alphaR gene even in WKY derived VSMCs , whereas that of C / EBP beta had an opposite effect in SHR derived VSMCs . ^^^ These findings indicate that differential expression of members of the C / EBP family , mainly C / EBP delta and possibly C / EBP beta , are responsible for the strain specific gene transcription of PDGF alphaR in VSMCs . . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Whereas C / EBP beta mRNA was induced approximately 50 fold , C / EBP delta mRNA was induced 5 to 8 fold by cAMP in Sertoli cells . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
By immunohistochemistry , we demonstrated that C / EBP alpha and C / EBP beta were expressed in alveolar type 2 cells and alveolar macrophages , but C / EBP delta was expressed restrictedly in some of alveolar type 2 cells in a spatial pattern in the control lungs . ^^^ Further , these three C / EBP family members were differentially expressed in alveolar cell proliferation and in acute lung injury , in which , interestingly , C / EBP alpha and C / EBP delta were reciprocally expressed in alveolar type 2 cell proliferation and in pulmonary fibrosis . ^^^ However , expressions of their mRNAs by in situ hybridization were dramatically increased in the affected lesions of the lungs by LPS and Bleo , and Northern blot analysis showed an increased abundance of the mRNA for C / EBP beta in LPS treated lungs and for C / EBP delta in Bleo treated lungs , compared with those in the control lungs . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Local signals induce CCAAT / enhancer binding protein delta ( C / EBP delta ) and C / EBP beta mRNA expression in the involuting mouse mammary gland . ^^^ Our laboratory and others have shown that C / EBP delta and C / EBP beta mRNA expression is closely associated with normal mouse mammary gland involution . ^^^ C / EBP delta mRNA levels are low in nonsealed glands , but are rapidly and transiently induced in sealed glands by 24 h . ^^^ These data demonstrate that local factors are sufficient to induce C / EBP beta and C / EBP delta in the mouse mammary gland . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
CYP2B1 is regulated by C / EBP alpha and C / EBP delta inlung epithelial cells . ^^^ In this study we demonstrate the importance of C / EBP alpha and C / EBP delta in pulmonary epithelial CYP2B1 gene expression . ^^^ Both C / EBP alpha and C / EBP delta transactivated the CYP2B1 promoter in the lung epithelial cell lines A 549 and NCI H 441 . ^^^ Site directed mutagenesis studies showed that this proximal C / EBP binding site is necessary for transactivation of the CYP2B1 gene by C / EBP alpha and C / EBP delta . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Induction of PPAR gamma gene transcription during the differentiation of preadipocytes into adipocytes in vitro occurs following an initial phase of cell proliferation and requires a direct involvement of C / EBP beta , C / EBP delta , and glucocorticoids . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Cell specific expression of CCAAT / enhancer binding protein delta ( C / EBP delta ) in epithelial lung cells . ^^^ In epithelial lung cells the C / EBP alpha isoform seems to play a role in the regulation of surfactant proteins ( SP ) and Clara cell specific protein ( CCSP ) , whereas the roles of C / EBP beta and C / EBP delta are unclear . ^^^ We have examined the protein levels of C / EBP delta in bronchiolar Clara cells and alveolar type 2 cells , and its relation to the expression of lung specific proteins and cell proliferation . ^^^ The protein expression of C / EBP delta was high in freshly isolated Clara cells compared to type 2 cells . ^^^ In both cell types C / EBP delta levels increased during culture . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Moreover , transient expression of C / EBP alpha , but not C / EBP delta , in the hepatoma cell line AT3F cells abolished the COX 2 promoter activity . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Exposure of the cells to LPS , IL 1 , IFN gamma and TNF alpha produced a reduction of C / EBP alpha mRNA levels and a corresponding increase in the expression of C / EBP beta and C / EBP delta . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Activation by RB was mediated through a NF IL 6 ( C / EBP beta ) binding motif in the human SP D promoter , and this sequence specifically bound to C / EBP alpha , C / EBP beta , and C / EBP delta . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
The induction of cyclooxygenase 2 mRNA in macrophages is biphasic and requires both CCAAT enhancer binding protein beta ( C / EBP beta ) and C / EBP delta transcription factors . ^^^ On the other hand , C / EBP delta appears to be essential in addition to C / EBP beta to effect the second phase of COX 2 gene transcription , which is important for maintaining the induced state and requires de novo protein synthesis . ^^^ Moreover , the synthesis of C / EBP delta was increased dramatically by treatment with lipopolysaccharide and , like COX 2 induction , repressed by combined inhibition of the MAPK and of the SAPK2 / p38 cascades . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Expression of dominant negative forms of CREB dramatically reduced the LIF and prostacyclin stimulated C / EBP beta and C / EBP delta expression . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Psychosine induced cytokine mediated nuclear translocation of AP 1 and C / EBP by potentiating the expression of Fra 1 and C / EBP delta proteins . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
In contrast to control plasmids , C / EBP delta expressing plasmids reversed the action of a transcriptional silencer just upstream of the rat SP A promoter . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
A role for C / EBP delta in human surfactant protein A ( SP A ) gene expression . ^^^ C / EBP delta , a member of the leucine zipper transcription factor family , is expressed at higher levels in the lung than in any other tissue . ^^^ We detected C / EBP delta mRNA and protein in NCI H 441 cells , a cell line derived from a human adenocarcinoma that produces surfactant protein A ( SP A ) . ^^^ NCI H 441 cells were exposed to phosphorothioate substituted antisense oligonucleotides directed against C / EBP delta . ^^^ After exposure to the oligonucleotides , cells were harvested , total RNA prepared , and levels of mRNA for C / EBP delta , SP A and a control , glyceraldehyde 3 phosphate dehydrogenase ( GAPDH ) , were quantified from Northern blots . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
As this element contains a CAAT / enhancer binding protein ( C / EBP ) motif , the function of C / EBP beta and C / EBP delta was examined . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
The overexpression of C / EBP beta and C / EBP delta but not C / EBP alpha caused 6 to 8 fold induction of MCP 1 promoter activity . ^^^ Consistently , the overexpression of p110CAAX as well as insulin induced mRNA expression and nuclear expression of C / EBP beta and C / EBP delta in VSMCs . ^^^ These results clearly indicate that the activation of PI3K induced proinflammatory gene expression through activating C / EBP beta and C / EBP delta but not NF kappaB , which may explain the proinflammatory effect of insulin in the insulin resistant state . . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
We show that functionally related domains are present in C / EBP alpha , C / EBP beta , and C / EBP delta . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
These mice express C / EBP alpha , C / EBP beta , and C / EBP delta in the bone marrow at levels similar to those of their wild type counterparts , suggesting a lack of functional redundancy among the family in vivo . ^^^ C / EBP beta and C / EBP delta proteins weakly induced B 9 expression , but C / EBP delta induced NC expression more efficiently than the other C / EBPs . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Posttranscriptional and posttranslational regulation of C / EBP delta in G 0 growth arrested mammary epithelial cells . ^^^ Previous work from our laboratory demonstrated that CCAAT / enhancer binding protein delta ( C / EBP delta ) functions in the initiation and maintenance of G ( 0 ) growth arrest in mouse mammary epithelial cells ( MECs ) . ^^^ In this report , we investigated the posttranscriptional and posttranslational regulation of C / EBP delta in G ( 0 ) growth arrested mouse MECs . ^^^ The results of transcriptional inhibitor studies demonstrated that the C / EBP delta mRNA exhibits a relatively short half life in G ( 0 ) growth arrested mouse MECs ( t ( 1 / 2 ) approximately 35 min ) . ^^^ In contrast , C / EBP delta mRNA has a longer half life in G ( 0 ) growth arrested mouse fibroblast cells ( t ( 1 / 2 ) > 100 min ) . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Antibody supershift experiments revealed that LPS induced C / EBP DNA binding activity depended on C / EBP beta and C / EBP delta but not C / EBP alpha , C / EBP epsilon or CBP / p300 . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
An AU rich element in the 3 ' untranslated region of the C / EBP delta mRNA is important for protein binding during G 0 growth arrest . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
In contrast , C / EBP delta exhibits a diffuse distribution in the nucleus that is not modified by GH treatment . ^^^ DNA binding analysis shows that C / EBP beta , C / EBP delta , and C / EBP alpha ( p 42 and p 30 forms ) can bind to satellite DNA as homo or heterocomplexes in vitro . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Keratinocyte growth factor and the transcription factors C / EBP alpha , C / EBP delta , and SREBP 1c regulate fatty acid synthesis in alveolar type 2 cells . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
The induction of C / EBP DNA binding activity by LPS and glucose was attributable mainly to the increase in C / EBP delta protein . ^^^ The cotransfection with wild type C / EBP delta increased the iNOS promoter activity to the level achieved with a higher glucose concentration in the presence of LPS . ^^^ Therefore , our results suggest that C / EBP delta may be a critical mediator in glucose mediated regulation of iNOS gene expression . . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Potential human specific changes included greater inflammatory responses [ chemokine ( C C motif ) ligand 2 , C / EBP delta , and IL 1 receptor ] and vascular remodeling ( tenascin C and lipocortin 2 ) . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
It also inhibits nuclear translocation of CCAAT / enhancer binding protein ( C / EBP ) transcription factor by inhibiting the expression of C / EBP delta in brain glial cells . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Over expression of C / EBP alpha gene in activated HSCs : ( 1 ) inhibited HSCs proliferation , extracellular matrix producing , alpha smooth muscle actin gene expression , and induced rebound of cytoplasmic lipid droplets ; ( 2 ) reduced retinoic acid receptor beta , C / EBP delta and beta gene expressions , but increased the active form C / EBP beta PSer ( 105 ) , and induced retinoid 10 receptor alpha gene expression ; and ( 3 ) did not affect the protein level of p16INK4a , p21Cip1 / WAF1 or p27Kip1 . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Similarly cotransfection of GR and C / EBP beta or C / EBP delta increases the promoter activity of reporter construct containing nucleoside A at 217 . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Isopentenyladenine ( IPA ) , a potent cytokinin , significantly induced the expression of CCAAT / enhancer binding protein ( C / EBP ) delta , but not C / EBP alpha protein , whereas all trans retinoic acid , a well known inducer of granulocytic differentiation , induced C / EBP alpha but not C / EBP delta protein . ^^^ Antisense oligonucleotide for C / EBP delta , but not C / EBP alpha or C / EBP beta , effectively suppressed IPA induced differentiation , suggesting that the expression of C / EBP delta protein is necessary for cytokinin induced differentiation . ^^^ Although C / EBP alpha is known to be crucial for granulocytic differentiation , the function of C / EBP delta has not been well documented in the regulation of haematopoiesis . ^^^ The role of C / EBP delta in the granulocytic differentiation of myeloid leukaemia cells is discussed . . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
IL 1 beta dependent regulation of C / EBP delta transcriptional activity . ^^^ We have previously shown that the transcription factor C / EBP delta is involved in the intestinal inflammatory response . ^^^ C / EBP delta regulates several inflammatory response genes , such as haptoglobin , in the rat intestinal epithelial cell line IEC 6 in response to IL 1 . ^^^ However , the different C / EBP delta domains involved in IL 1 beta mediated transcriptional activation and the kinases implicated have not been properly defined . ^^^ To address this , we determined the role of the p 38 MAP kinase in the regulation of C / EBP delta transcriptional activity . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
CCAAT / enhancer binding protein delta ( C / EBP delta ) is one of the transcription factors that have a basic leucine zipper domain . ^^^ We cloned Xenopus homologues of the C / EBP delta gene from metamorphosing stomach by subtractive hybridization and analyzed spatio temporal expression pattern of the homologues . ^^^ Two isoforms of C / EBP delta were isolated and named C / EBP delta 1 and 2 . ^^^ Expression of the C / EBP delta mRNAs in the stomach transiently increased during its metamorphosis associated remodeling , and the transient up regulation was also found in thyroid hormone induced metamorphosis . ^^^ The C / EBP delta mRNAs were exclusively localized in degenerating larval surface mucous cells , not in newly proliferating and differentiating adult type epithelial cells . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Indeed , both NaBu and IL 1beta led to increased recruitment of NF kappa B p 65 , C / EBPbeta , and C / EBP delta , and decreased NF kappa B p 50 and C / EBP alpha DNA binding to the proximal SAA 2 promoter , as assessed by chromatin immunoprecipitation assays . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Expression of C / EBP delta in rat liver during development and the acute phase response . ^^^ Using Western analysis , C / EBP delta was established in the nuclear extract and nuclear matrix throughout rat liver development and in the adult . ^^^ During the acute phase response ( APR ) , C / EBP delta increased in the nuclear extract but remained unchanged in the nuclear matrix of fetal and postnatal rats , whereas it increased in both the nuclear extract and nuclear matrix of the adult . ^^^ The obtained different solubility partitioning profiles of C / EBP delta suggest that its activity is regulated by different mechanisms during development and in the adult . . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
We have previously reported that chronic activation of phosphatidylinositol 3 kinase ( PI 3 kinase ) by the overexpression of membrane targeted p110CAAX induced proinflammatory gene expression in rat vascular smooth muscle cells ( VSMCs ) through the induction of CCAAT / enhancer binding protein beta ( C / EBP beta ) and C / EBP delta . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
In contrast , mice lacking the related gene , C / EBP delta , were not resistant to DMBA induced skin tumorigenesis , indicating a unique role of C / EBP beta in skin tumor development . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
A member of the C / EBP family , NF IL 6 beta , forms a heterodimer and transcriptionally synergizes with NF IL 6 . ^^^ This intronless gene , termed NF IL 6 beta encodes a 269 amino acid protein with a potential leucine zipper structure , and the gene product can bind to the CCAAT homology as well as the viral enhancer core sequence , as in the cases of NF IL 6 and C / EBP . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
We have identified and characterized putative zebrafish orthologs of mammalian C / EBP alpha , beta , gamma , and delta using low stringency hybridization screening and computer searches of the GenBank EST database . c / ebpa and g were mapped within 1 cM of each other on linkage group ( LG ) 7 , syntenic with human CEBPA and G genes on chromosome 19 . c / ebpb was mapped to LG 8 , and c / ebpd was mapped to LG 24 , on the same LG as a recently identified unique c / ebp in zebrafish , c / ebp1 . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
The sequence analysis indicates that the novel protein , designated CELF , has a significant homology to C / EBP gene family proteins in the carboxyl terminal part containing the basic region and the leucine zipper motif . ^^^
Interacting proteins: P49716 and P49715	Pubmed	SVM Score :0.0
Three genes were isolated that encode bZIP DNA binding proteins ( designated CRP 1 , CRP 2 , and CRP 3 ) with strong amino acid sequence similarities to the C / EBP binding domain . ^^^