| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.6520559 |
| NF IL 6 beta easily forms a heterodimer with NF IL 6 in vitro and the heterodimeric complex binds to the same DNA sequence as the respective homodimers . 0.6520559^^^ This intronless gene , termed NF IL 6 beta encodes a 269 amino acid protein with a potential leucine zipper structure , and the gene product can bind to the CCAAT homology as well as the viral enhancer core sequence , as in the cases of NF IL 6 and C / EBP . 0.53408487^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Members of the C / EBP alpha and C / EBP beta , but not C / EBP delta , family are able to bind to these two sites . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| In contrast , overexpression of C / EBP beta or C / EBP delta had no effect on hepatoma cell growth . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| C / EBP beta , C / EBP alpha , and C / EBP delta , which bind to element C , prevented the inhibition of promoter activity . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| We show that functionally related domains are present in C / EBP alpha , C / EBP beta , and C / EBP delta . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Supershift analysis revealed upregulated DNA binding activity of C / EBP beta but not C / EBP delta . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| In the presence of the correct hormonal cues , committed pre adipocytes express the bZIP factors C / EBPb and C / EBPd . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| They were found to overlap the two low affinity binding sites , CRP 2 and CRP 3 , determined previously for CRP . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| The steady state levels of C / EBP beta and a new isoform , C / EBP delta , were dramatically increased in many tissues within 4 h following LPS treatment . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Using Western blotting and immunohistochemical staining , we have determined the temporal order of expression for C / EBP alpha , C / EBP beta , and C / EBP delta in differentiating myelomonocytic marrow cells . ^^^ While we have detected C / EBP alpha , C / EBP beta , and C / EBP delta in multiple myeloid leukemia cell lines , and C / EBP alpha in normal myeloid cells and in de novo human myeloid leukemias , we have not detected these C / EBP isoforms in either erythroid or lymphoid cells . ^^^ Finally , we show that C / EBP alpha , C / EBP beta , and C / EBP delta protein and messenger RNA levels correlate in maturing granulocytic cells . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| The proteins encoded by these C / EBP related genes , termed C / EBP beta and C / EBP delta , exhibit similar DNA binding specificities and affinities compared with C / EBP alpha . ^^^ Furthermore , C / EBP beta and C / EBP delta readily form heterodimers with one another as well as with C / EBP alpha . ^^^ The transcriptional activating capacity of these two newly identified C / EBP isoforms was demonstrated by transient transfection experiments in which expression vectors encoding C / EBP beta and C / EBP delta were observed to induce transcription from the promoter of the serum albumin gene in cultured hepatoma cells . ^^^ The mRNAs encoding C / EBP beta and C / EBP delta were detected in a number of tissues , most of which corresponded to sites of expression of C / EBP alpha . ^^^ The expression pattern of C / EBP beta and C / EBP delta during adipose conversion of 3T3 L 1 cells was examined by Western and Northern blotting assays . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| The genetic program undertaken during the clonal expansion phase of 3T3 L 1 differentiation , controlled in part by C / EBP beta and C / EBP delta , is less clearly understood . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| We suggest that C / EBP delta could be involved in the initial activation of epithelial progenitor cells and that HNF 3 alpha , beta , and gamma , and C / EBP beta might participate in their maturation . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| In this study , we demonstrate that the involved inducible C / EBP isoforms are C / EBP beta and C / EBP delta , and together they control the high level induction of the alpha 1 acid glycoprotein gene in response to inflammatory signals . ^^^ Transient transfections using expression vectors of C / EBP alpha , C / EBP beta and C / EBP delta have shown that while individually all three isoforms can transactivate the alpha 1 acid glycoprotein chloramphenicol acetyltransferase gene transcription , co expression of C / EBP alpha and C / EBP beta isoforms results in lower levels of reporter gene expression than the levels predicted from their additive transactivation level . ^^^ Higher than additive levels of reporter gene expression are observed when combinations of C / EBP delta and C / EBP beta or C / EBP delta and C / EBP alpha are used . ^^^ Together , these data demonstrate that C / EBP beta and C / EBP delta are the major proteins responsible for the acute phase induction of alpha 1 acid glycoprotein gene expression and they require phosphorylation for transactivation potential . . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| During the early phase of differentiation , high levels of C / EBP delta and C / EBP beta accumulate . ^^^ Here we provide evidence that C / EBP delta and C / EBP beta play early catalytic roles in the differentiation pathway , relaying the effects of the hormonal stimulants DEX and MIX in a cascade like fashion , leading to the activation of the gene encoding C / EBP alpha . ^^^ Conditions facilitating the precocious expression of either C / EBP delta or C / EBP beta were observed to accelerate adipogenesis and , in the case of C / EBP beta , relieve dependence on the early hormonal stimulants . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Increased c fos , c jun , C / EBP beta , and C / EBP delta mRNA expression was correlated with increased DNA binding activity of the transcription factor complexes activator protein 1 and C / EBP in tissue lysates . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Gel mobility shift and transient expression analyses showed that C / EBP beta and C / EBP isoforms , C / EBP alpha and C / EBP delta , bind to the PISII element and trans activate rnCGM 3 gene expression . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Early responses of trans activating factors to growth hormone in preadipocytes : differential regulation of CCAAT enhancer binding protein beta ( C / EBP beta ) and C / EBP delta . ^^^ Concomitant with the translationally activated increase in C / EBP beta , a GH dependent increase was observed in C / EBP delta transcription . ^^^ This was accompanied by an increase in mRNA for C / EBP delta , which was superinduced by cycloheximide and , unlike the increase in C / EBP beta protein , was not observed with insulin . ^^^ Thus GH exerts its effects on C / EBP isoforms at two levels : transcriptional activation of C / EBP delta and translational activation of C / EBP beta . ^^^ It is proposed that GH dependent phosphorylation results in the efficient translation of 40 C / EBP beta and 23 C / EBP beta ( the mouse homolog of the inhibitor liver enriched inhibitory protein ) , and that together with the induction of C / EBP delta , these may be involved in initiating the adipocyte differentiation program . . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| We have examined its expression during the acute phase response ( APR ) and have shown that like C / EBP beta and C / EBP delta , GADD 153 mRNA is markedly induced in livers of rats treated with lipopolysaccharide to initiate the APR . ^^^ Interestingly , its induction is temporally delayed relative to that of C / EBP beta and C / EBP delta but is similar to that of acute phase reactants shown to be regulated by C / EBPs . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| The two ccaat enhancer binding protein isoforms , IL 6DBP and C / EBP delta , are induced by interleukin 6 to promote gene transcription in hepatocytes via different mechanisms . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| While insulin induced expression of C / EBP beta and C / EBP delta within 1 h and caused a > 20 fold increase by 4 h , expression returned to nearly pretreatment levels by 24 h . ^^^ Gel shift analysis revealed that 6 h of insulin treatment decreased the binding of nuclear C / EBP alpha while increasing binding of nuclear C / EBP beta and C / EBP delta . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Nuclear expression of the 36 kilodalton C / EBP delta protein increases immediately after birth , followed first by increases in the 38 kilodalton C / EBP beta protein expression and then by increases in the 42 kilodalton C / EBP alpha protein expression . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| C / EBP alpha , C / EBP beta , and C / EBP delta were capable of interacting with elements A and B . ^^^ Under noninduced conditions , C / EBP alpha was the major binding factor ; however , upon cytokine stimulation C / EBP beta and C / EBP delta binding activities were dramatically increased and became the predominant binding factors . ^^^ Consistent with these binding studies were the cotransfection experiments in which C / EBP beta and C / EBP delta were shown to be potent transactivators for the SAA 3 promoter . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Neonatal mouse liver expresses C / EBP alpha , C / EBP beta and C / EBP delta mRNAs . ^^^ In contrast neonatal mouse brain expresses high levels of C / EBP delta , but little C / EBP alpha or C / EBP beta mRNA . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Serum amyloid A gene expression under acute phase conditions involves participation of inducible C / EBP beta and C / EBP delta and their activation by phosphorylation . ^^^ In this study , using antibodies against three C / EBP isoforms in DNA binding and Western blot ( immunoblot ) assays , we found that in response to inflammatory signals , both C / EBP delta and C / EBP beta are induced and that their interactions with the SAA promoter element are necessary for the increased SAA gene expression . ^^^ Cotransfections of liver cells with an SAA promoter linked reporter chloramphenicol acetyltransferase gene and murine sarcoma virus expressed C / EBP delta or C / EBP beta confirm such phenomena . ^^^ These results suggest that C / EBP delta is regulated by phosphorylation and , in conjunction with C / EBP beta , is one of the major proteins responsible for the increased transcription of the SAA gene in response to inflammatory stimuli . . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Anti C / EBP beta ( NFIL 6 ) and anti C / EBP delta ( NFIL 6 beta ) Abs identified both of these proteins in complexes formed between the NFIL 6 like element and mononuclear cell nuclear extracts . ^^^ These data are consistent with the requirement for C / EBP beta ( NFIL 6 ) and C / EBP delta ( NFIL 6 beta ) in the activation of murine IL 1 beta gene expression by endotoxin . . ^^^ C / EBP delta ( NFIL 6 beta ) was not detected in complexes utilizing extracts from the IL 1 nonproducing T cell line . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| The C / EBP family consist of several related proteins , C / EBP alpha , C / EBP beta , C / EBP gamma , and C / EBP delta , that form homodimers and that form heterodimers with each other . ^^^ NF kappa B p 65 , p 50 , and Rel functionally synergize with C / EBP alpha , C / EBP beta , and C / EBP delta . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Using monospecific antibodies we demonstrate that three isoforms of the CCAAT / enhancer binding protein ( C / EBP ) family , namely C / EBP alpha , C / EBP beta , and C / EBP delta , bind to the APRE . ^^^ Finally , functional analyses indicate that C / EBP alpha , C / EBP beta , and C / EBP delta are strong transcriptional trans activators of the AGP APRE in hepatoma cells . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| To assess whether these factors might be involved in the hepatocyte proliferation program , we have studied the expression of the three C / EBP isoforms C / EBP alpha , C / EBP beta , and C / EBP delta and the two hepatocyte enriched transcription factors , HNF 1 and HNF 4 , in rat liver at various time points after partial hepatectomy and sham operations using transcriptional `` run on ' ' assays and Northern blot and Western blot experiments . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| The related C / EBP beta and C / EBP delta proteins are not detectable by sensitive immunocytochemical methods in epithelial cells distributed along the duodenal to colonic axis . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Mouse chromosomal location of the CCAAT / enhancer binding proteins C / EBP beta ( Cebpb ) , C / EBP delta ( Cebpd ) , and CRP 1 ( Cebpe ) . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Immunofluorescence studies show cytoplasmic and nuclear localization for C / EBP alpha , in contrast to a restricted nuclear localization for both C / EBP beta and C / EBP delta . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| We report in this study that in these cells , C / EBP beta and C / EBP delta are induced by VIP , PACAP , or NA via the cAMP second messenger pathway . ^^^ Thus , c / ebp beta and c / ebp delta behave as cAMP inducible immediate early genes in astrocytes . ^^^ Moreover , transfection of astrocytes with expression vectors selectively producing the transcriptionally active form of C / EBP beta , termed liver enriched transcriptional activator protein , or C / EBP delta enhance the glycogen resynthesis elicited by NA , whereas an expression vector producing the transcriptionally inactive form of C / EBP beta , termed liver enriched transcriptional inhibitory protein , reduces this resynthesis . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| These mutations abolished the binding of rat liver nuclear activities as well as transcription factors C / EBP alpha , C / EBP beta , and C / EBP delta expressed in COS 1 cell lysates to element D . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| To date , we have only found evidence for involvement of C / EBP alpha , although further experiments will be needed to exclude the role of C / EBP beta and C / EBP delta in receptor gene expression . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Unexpectedly , a significant activation of 3xNF kappaBCAT was also seen upon its co transfection with the expression vector for CCAAT box enhancer binding protein alpha ( C / EBP alpha ) ( but not C / EBP beta or C / EBP delta ) . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Analysis of mRNA for three isoforms of the CCAAT / enhancer binding protein ( C / EBP ) revealed that TCDD ( 5 nM ) selectively inhibited the induction of C / EBP alpha mRNA but did not block the induction of C / EBP beta and C / EBP delta in response to differentiation inducers . ^^^ Immunoblot analysis with specific antibodies to each C / EBP isoform demonstrated that the levels of C / EBP delta and C / EBP beta protein were rapidly induced ( by day 1 ) and then abrogated by day 4 and 8 , respectively , in solvent treated ( control ) cells . ^^^ In TCDD treated cells , however , the levels of C / EBP beta and C / EBP delta protein persisted at these time points . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Effect of thermal injury on the expression of transcription factors that regulate acute phase response genes : the response of C / EBP alpha , C / EBP beta , and C / EBP delta to thermal injury . ^^^ Northern blot hybridization was performed with 32P labeled C / EBP alpha , C / EBP beta , and C / EBP delta cDNAs . ^^^ A simultaneous decrease in C / EBP alpha and an increase in C / EBP beta and C / EBP delta mRNA levels occur in response to thermal injury . ^^^ The responses of C / EBP alpha , C / EBP beta , and C / EBP delta are similar in Buffalo , Sprague Dawley , and Fischer rats . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Within 5 10 min after treatment with any of these agents , nuclear concentrations of C / EBP beta and C / EBP delta double and remain 2 4 fold greater than control cultures for 30 min ( p < 0 . 01 ) . ^^^ Consistent with these results , gel mobility shift assays demonstrate 3 fold increased nuclear C / EBP beta and C / EBP delta DNA binding activity in TNF alpha treated cells , and immunocytochemistry confirms rapid redistribution of these C / EBP isoforms into the nucleus . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| In this group , PH caused 12 to 16 fold greater induction of interleukin 6 , a TNF inducible cytokine , and two to threefold greater induction of several cytokine regulated genes ( c jun , C / EBP beta , and C / EBP delta ) . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Nuclear factor kappa B ( NF kappa B ) , nuclear factor interleukin 6 ( NFIL 6 or C / EBP beta ) and nuclear factor interleukin 6 beta ( NFIL 6 beta or C / EBP delta ) are not sufficient to activate the endogenous interleukin 6 gene in the human breast carcinoma cell line MCF 7 . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Induction of hemopexin , alpha 1 acid glycoprotein , alpha 2 macroglobulin , GADD 153 , C / EBP beta , and C / EBP delta mRNAs by LPS were all abolished in dexamethasone treated rats . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Finally , transfection experiments , in which NF kappa B subunits , NFIL 6 , and NFIL 6 beta ( C / EBP delta ) , were overexpressed in cells transfected with mutated IL 6 enhancer elements linked to a reporter gene show that interaction between members of the two families of factors is required for activation of the IL 6 gene in the absence of the NFIL 6 binding site . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| In contrast to COMMA D cells , C / EBP beta and C / EBP delta mRNA levels remain relatively constant in growth arrested and cell cycle induced NIH3T3 cells . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| The NF IL 6 like complex contains subunit C / EBP beta ( NF IL 6alpha ) as one of its components , but apparently not C / EBP alpha or C / EBP delta ( NF IL 6beta ) . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| In contrast to mammary gland , C / EBP alpha is the predominate isoform expressed in liver with relatively low expression of C / EBP beta and C / EBP delta mRNA . ^^^ The pronounced sequential induction of C / EBP delta and C / EBP beta during postlactational involution is consistent with a role for C / EBPs in the regulation of mammary epithelial cell apoptosis . . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Thus , expression of HNF3gamma , C / EBP alpha , and C / EBP beta may be necessary for hepatocytes to acquire highly differentiated functions in addition to coexpression of certain amounts of transcripts of HNF1alpha , HNF1beta , HNF3alpha , HNF3beta , and HNF 4 as well as suppression of C / EBP delta . . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Since C / EBP beta deficient mice have been reported to be largely normal in their expression of proinflammatory cytokines , it is likely that the lack of C / EBP beta is compensated for by the induction of C / EBP delta upon LPS treatment . . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| C / EBP beta , C / EBP delta and ADD 1 / SREBP 1 are active early during the differentiation process and induce the expression and / or activity of the peroxisome proliferator activated receptor gamma ( PPAR gamma ) , the pivotal coordinator of the adipocyte differentiation process . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| In addition , C / EBP beta and C / EBP delta , but not C / EBP alpha , bind specifically to the C / EBP site of SAA 2 in response to IL 6 stimulation . ^^^ Transient co transfection analysis indicates that co operative association of NF kappa B p 65 with C / EBP beta and , in particular , with C / EBP delta , results in synergistic transcriptional activation of the SAA 2 promoter . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| DNA protein binding studies by competition in electromobility shift and supershift assays revealed that 2 members , C / EBP beta and C / EBP delta , are mainly responsible for DNA protein complex formation ; the former acts as a transcriptional repressor and the latter as an activator of the PDGF alphaR gene , respectively . ^^^ Furthermore , forced expression of C / EBP delta transactivated the transcriptional efficiency of the PDGF alphaR gene even in WKY derived VSMCs , whereas that of C / EBP beta had an opposite effect in SHR derived VSMCs . ^^^ These findings indicate that differential expression of members of the C / EBP family , mainly C / EBP delta and possibly C / EBP beta , are responsible for the strain specific gene transcription of PDGF alphaR in VSMCs . . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Whereas C / EBP beta mRNA was induced approximately 50 fold , C / EBP delta mRNA was induced 5 to 8 fold by cAMP in Sertoli cells . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| By immunohistochemistry , we demonstrated that C / EBP alpha and C / EBP beta were expressed in alveolar type 2 cells and alveolar macrophages , but C / EBP delta was expressed restrictedly in some of alveolar type 2 cells in a spatial pattern in the control lungs . ^^^ However , expressions of their mRNAs by in situ hybridization were dramatically increased in the affected lesions of the lungs by LPS and Bleo , and Northern blot analysis showed an increased abundance of the mRNA for C / EBP beta in LPS treated lungs and for C / EBP delta in Bleo treated lungs , compared with those in the control lungs . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Local signals induce CCAAT / enhancer binding protein delta ( C / EBP delta ) and C / EBP beta mRNA expression in the involuting mouse mammary gland . ^^^ Our laboratory and others have shown that C / EBP delta and C / EBP beta mRNA expression is closely associated with normal mouse mammary gland involution . ^^^ These data demonstrate that local factors are sufficient to induce C / EBP beta and C / EBP delta in the mouse mammary gland . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Induction of PPAR gamma gene transcription during the differentiation of preadipocytes into adipocytes in vitro occurs following an initial phase of cell proliferation and requires a direct involvement of C / EBP beta , C / EBP delta , and glucocorticoids . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| In epithelial lung cells the C / EBP alpha isoform seems to play a role in the regulation of surfactant proteins ( SP ) and Clara cell specific protein ( CCSP ) , whereas the roles of C / EBP beta and C / EBP delta are unclear . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Exposure of the cells to LPS , IL 1 , IFN gamma and TNF alpha produced a reduction of C / EBP alpha mRNA levels and a corresponding increase in the expression of C / EBP beta and C / EBP delta . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Activation by RB was mediated through a NF IL 6 ( C / EBP beta ) binding motif in the human SP D promoter , and this sequence specifically bound to C / EBP alpha , C / EBP beta , and C / EBP delta . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| The induction of cyclooxygenase 2 mRNA in macrophages is biphasic and requires both CCAAT enhancer binding protein beta ( C / EBP beta ) and C / EBP delta transcription factors . ^^^ On the other hand , C / EBP delta appears to be essential in addition to C / EBP beta to effect the second phase of COX 2 gene transcription , which is important for maintaining the induced state and requires de novo protein synthesis . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Expression of dominant negative forms of CREB dramatically reduced the LIF and prostacyclin stimulated C / EBP beta and C / EBP delta expression . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| C / EBP beta , C / EBP delta , PU . 1 , AML 1 genes : mutational analysis in 381 samples of hematopoietic and solid malignancies . ^^^ Mutation of C / EBP beta ( a chronic myelogenous leukemia cell line , Kcl 22 ) and C / EBP delta ( a Burkitt ' s lymphoma cell line , Raji ) were found . ^^^ These findings suggest that mutations of the C / EBP beta , C / EBP delta , PU . 1 , and AML 1 rarely contribute to the development of hematopoietic or solid cancers . . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| As this element contains a CAAT / enhancer binding protein ( C / EBP ) motif , the function of C / EBP beta and C / EBP delta was examined . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| The overexpression of C / EBP beta and C / EBP delta but not C / EBP alpha caused 6 to 8 fold induction of MCP 1 promoter activity . ^^^ Consistently , the overexpression of p110CAAX as well as insulin induced mRNA expression and nuclear expression of C / EBP beta and C / EBP delta in VSMCs . ^^^ These results clearly indicate that the activation of PI3K induced proinflammatory gene expression through activating C / EBP beta and C / EBP delta but not NF kappaB , which may explain the proinflammatory effect of insulin in the insulin resistant state . . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| These mice express C / EBP alpha , C / EBP beta , and C / EBP delta in the bone marrow at levels similar to those of their wild type counterparts , suggesting a lack of functional redundancy among the family in vivo . ^^^ C / EBP beta and C / EBP delta proteins weakly induced B 9 expression , but C / EBP delta induced NC expression more efficiently than the other C / EBPs . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Expression of C / EBP beta , C / EBP delta , and C / EBP zeta was observed from the MC / MM stage onward , with peak levels in the most mature cells . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Antibody supershift experiments revealed that LPS induced C / EBP DNA binding activity depended on C / EBP beta and C / EBP delta but not C / EBP alpha , C / EBP epsilon or CBP / p300 . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| DNA binding analysis shows that C / EBP beta , C / EBP delta , and C / EBP alpha ( p 42 and p 30 forms ) can bind to satellite DNA as homo or heterocomplexes in vitro . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| In this study , we have compared mouse mammary gland involution in the 129S1 and C57BL / 6 inbred strains and report significant differences at the molecular level with differential expression of Bcl2a1 ( Bfl 1 ) , Trp 53 ( p 53 ) , Cebpb ( C / EBP beta ) , and Cebpd ( C / EBP delta ) . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Over expression of C / EBP alpha gene in activated HSCs : ( 1 ) inhibited HSCs proliferation , extracellular matrix producing , alpha smooth muscle actin gene expression , and induced rebound of cytoplasmic lipid droplets ; ( 2 ) reduced retinoic acid receptor beta , C / EBP delta and beta gene expressions , but increased the active form C / EBP beta PSer ( 105 ) , and induced retinoid 10 receptor alpha gene expression ; and ( 3 ) did not affect the protein level of p16INK4a , p21Cip1 / WAF1 or p27Kip1 . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Similarly cotransfection of GR and C / EBP beta or C / EBP delta increases the promoter activity of reporter construct containing nucleoside A at 217 . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Antisense oligonucleotide for C / EBP delta , but not C / EBP alpha or C / EBP beta , effectively suppressed IPA induced differentiation , suggesting that the expression of C / EBP delta protein is necessary for cytokinin induced differentiation . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| We have previously reported that chronic activation of phosphatidylinositol 3 kinase ( PI 3 kinase ) by the overexpression of membrane targeted p110CAAX induced proinflammatory gene expression in rat vascular smooth muscle cells ( VSMCs ) through the induction of CCAAT / enhancer binding protein beta ( C / EBP beta ) and C / EBP delta . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| In contrast , mice lacking the related gene , C / EBP delta , were not resistant to DMBA induced skin tumorigenesis , indicating a unique role of C / EBP beta in skin tumor development . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| IL 6 is able to activate the hsp 90 gene promoter directly ; this activation can also be achieved by overexpressing either of the transcription factors NF IL 6 or NF IL 6 beta whose synthesis is induced by IL 6 treatment . ^^^ Hence the induction of hsp 90 protein accumulation by IL 6 is likely to be dependent on the enhanced activity of the hsp 90 beta gene promoter produced by increased levels of NF IL 6 and / or NF IL 6 beta . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| We have identified and characterized putative zebrafish orthologs of mammalian C / EBP alpha , beta , gamma , and delta using low stringency hybridization screening and computer searches of the GenBank EST database . c / ebpa and g were mapped within 1 cM of each other on linkage group ( LG ) 7 , syntenic with human CEBPA and G genes on chromosome 19 . c / ebpb was mapped to LG 8 , and c / ebpd was mapped to LG 24 , on the same LG as a recently identified unique c / ebp in zebrafish , c / ebp1 . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| By combining genetic studies and footprinting analyses , we demonstrate that regulated expression of the CytR controlled cdd promoter requires three CRP binding sites : a high affinity site ( CRP 1 ) and two overlapping low affinity sites ( CRP 2 and CRP 3 ) centred at positions 41 , 91 and 93 , respectively . ^^^ Moreover , mutant cdd promoters in which CRP 2 and CRP 3 have been deleted are partially regulated by CytR , and cAMP CRP and CytR still bind cooperatively to these promoters . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| CRP 2 is identical to the protein described recently by other groups as NF IL 6 , LAP , IL 6DBP , and AGP / EBP , whereas CRP 1 and CRP 3 represent novel proteins . ^^^ Three genes were isolated that encode bZIP DNA binding proteins ( designated CRP 1 , CRP 2 , and CRP 3 ) with strong amino acid sequence similarities to the C / EBP binding domain . ^^^ CRP 2 is identical to the protein described recently by other groups as NF IL 6 , LAP , IL 6DBP , and AGP / EBP , whereas CRP 1 and CRP 3 represent novel proteins . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| C / EBP related proteins 2 and 3 ( CRP 2 and CRP 3 ) are differentially expressed by P 388 lymphoblasts and their derivative P388D1 ( IL 1 ) macrophages . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| These tetrapeptides , resembling the aminoacid sequence of tuftsin ( CRP 1 , H gThr ( R , S ) mLys Pro Leu OH , ITF 1192 ; CRP 2 , H gGly ( R , S ) mLys Pro Arg OH , ITF 1127 ; CRP 3 , H gThr ( R , S ) mLys Pro Gln OH . ^^^ ITF 1193 ) , were able to induce NO synthesis by peritoneal macrophages in a dose dependent manner ; the most stimulating dose was 1000 ng ml 1 for CRP 2 and 100 ng ml 1 for CRP 1 and CRP 3 . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Proteins of the cysteine rich protein ( CRP ) family ( CRP 1 , CRP 2 , and CRP 3 ) are implicated in diverse processes linked to cellular differentiation and growth control . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Members of the cysteine and glycine rich protein ( CRP ) family ( CRP 1 , CRP 2 , and CRP 3 ) contain two zinc binding LIM domains , LIM 1 and LIM 2 , and are implicated in diverse cellular processes linked to differentiation , growth control and pathogenesis . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Members of the cysteine and glycine rich protein family ( CRP 1 , CRP 2 , and CRP 3 ) contain two zinc binding LIM domains , LIM 1 ( amino terminal ) and LIM 2 ( carboxyl terminal ) , and are implicated in diverse cellular processes linked to differentiation , growth control , and pathogenesis . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Together with SRF and GATA proteins , CRP 1 and CRP 2 converted pluripotent 10T1 / 2 fibroblasts into smooth muscle cells , while muscle LIM protein CRP 3 inhibited the conversion . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Serial CRP measurements were done at admission ( CRP 1 ) , within 24 hours ( CRP 2 ) , and within 48 hours ( CRP 3 ) after symptom onset . ^^^ RESULTS : The CRP concentration increased significantly during the first 48 hours after symptom onset ( CRP 1 , 0 . 86 mg / dL [ 95 % CI , 0 . 69 to 1 . 02 ] ; CRP 2 , 1 . 22 mg / dL [ 95 % CI , 0 . 88 to 1 . 55 ] ; CRP 3 , 1 . 75 mg / dL [ 95 % CI , 1 . 25 to 2 . 25 ] ; P=0 . 003 ) . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| Thus far , the latter function has been inferred solely from the in vitro interaction of CRP 1 , CRP 2 , and CRP 3 with alpha actinin and zyxin . ^^^ |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49716 and P17676 |
Pubmed |
SVM Score :0.0 |
| NA |
|