| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| The crystal structure of the heterodimer formed by the basic leucine zipper ( bZIP ) domains of activating transcription factor 4 ( ATF 4 ) and CCAAT box / enhancer binding protein beta ( C / EBP beta ) , from two different bZIP transcription factor families , has been determined and refined to 2 . 6 A . ^^^ |
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| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| Palmitate and oleate induced C / EBP homologous protein , activating transcription factor 4 , and immunoglobulin heavy chain binding protein mRNAs , 10 box binding protein 1 alternative splicing , and activation of the activating transcription factor 6 promoter in INS 1E cells , suggesting that FFAs trigger an endoplasmic reticulum ( ER ) stress response . ^^^ |
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| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| We have studied the activation of the UPR in VWM through the immunohistochemical expression of its upstream components PERK and phosphorylated eIF2alpha ( eIF2alphaP ) and combined immunohistochemical and Western blot analysis of the downstream effector proteins activating transcription factor 4 ( ATF 4 ) and C / EBP homologous protein ( CHOP ) in 4 VWM brains and 3 age matched controls . ^^^ |
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| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| INS 1 cells exposed to palmitate for 16 24 h under serum free conditions showed marked apoptosis and increased protein levels of phosphorylated eukaryotic translation initiation factor 2alpha ( eIF2alpha ) , activating transcription factor 4 ( ATF 4 ) , 10 box binding protein 1 ( XBP 1 ) , and C / EBP homologous transcription factor ( CHOP ) compared with control cells . ^^^ |
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| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| Chromatin immunoprecipitation assays show that 5 HT induces the downstream gene C / EBP by activating CREB 1 , which recruits CBP for histone acetylation , whereas FMRFa leads to CREB 1 displacement by CREB 2 and recruitment of HDAC 5 to deacetylate histones . ^^^ |
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| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| Inducible enhancement of memory storage and synaptic plasticity in transgenic mice expressing an inhibitor of ATF 4 ( CREB 2 ) and C / EBP proteins . ^^^ These results suggest that several proteins within the C / EBP family including ATF 4 ( CREB 2 ) act to constrain long term synaptic changes and memory formation . ^^^ |
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| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| C / EBPepsilon was found to associate with other C / EBP family members , including C / EBPepsilon and CHOP as well as other proteins that are known to contain a leucine zipper protein interaction motif including CREB 2 , LDOC 1 , E6TP1 , and AF 17 . ^^^ |
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| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| Other bZIP proteins , including CREB 2 , activating transcription factor 2 ( ATF 2 ) , or CAAT / enhancer binding protein ( C / EBP ) have been reported to transactivate CRE containing genes or to interfere with transactivation by CREB . ^^^ Experiments involving dominant negative bZIP mutants revealed that CREB does not heterodimerize with CREB 2 , ATF 2 , c Jun or C / EBP . ^^^ |
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| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| CCAAT / enhancer binding protein ( C / EBP ) basic region / leucine zipper ( bZIP ) transcription factors have been shown to form heterodimers with cAMP responsive element binding protein 2 ( CREB 2 ) , a transcription factor involved in regulating basal and Tax mediated transactivation of the human T cell leukemia virus type 1 ( HTLV 1 ) long terminal repeat ( LTR ) . ^^^ |
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| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| Normal fibroblasts induce the C / EBP beta and ATF 4 bZIP transcription factors in response to anoxia . ^^^ |
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| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| We predicted that ATF 4 , a member of the ATF / CREB family of transcription factors , would preferentially form heterodimers with IGEBP 1 , a member of the C / EBP superfamily . ^^^ |
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| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| During arsenite treatment of PC 12 cells , we observed enhanced binding of ATF 4 to the C / EBP ATF site at 2 h as Gadd 153 mRNA levels increased , and enhanced binding of ATF 3 complexes at 6 h as Gadd 153 expression declined . ^^^ We further demonstrated that ATF 4 activates , while ATF 3 represses , Gadd 153 promoter activity through the C / EBP ATF site . ^^^ |
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| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| In addition to its own family members , ATF 4 can also form heterodimers with other related but distinct bZIP proteins such as the C / EBP , AP 1 and Maf families , which may give rise to a variety of combinatorial diversity in gene regulation . ^^^ |
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| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| In order to determine the identities of individual B ZIP proteins in various AP 1 complexes we tested the effect of dominant negative mutants to the B ZIP proteins c Fos , ATF 2 , ATF 4 and CCAAT enhancer binding protein ( C / EBP ) on the activities of the collagenase and c Jun promoters . ^^^ However , A ATF 4 and A C / EBP had no effect . ^^^ |
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| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| The transcriptional activity of the GADD 153 promoter as well as transcription from the C / EBP activating transcription factor ( ATF ) composite motif in the GADD 153 promoter was also stimulated by HRG inducible ATF 4 and activated HER 2 but not wild type HER 2 . ^^^ |
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| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| Notably , stress induced transcription factors such as ATF 3 , ATF 4 , CHOP , and C / EBP beta were robustly up regulated , yet exhibited unique kinetic patterns . ^^^ |
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| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| Furthermore , arylating quinones induced endoplasmic reticulum ( ER ) stress by activating the pancreatic ER kinase ( PERK ) signaling pathway including elF2alpha , ATF 4 , and C / EBP homologous protein ( CHOP ) . ^^^ |
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| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| In contrast , dominant negative mutants of the transcription factors activating transcription factor ( ATF ) 2 , ATF 4 , cAMP response element binding protein , c Jun and CCAAT / enhancer binding protein ( C / EBP ) did not change TPA induced tyrosine hydroxylase promoter activity , indicating that these proteins are not part of the TPA mediated signalling cascade directed towards the tyrosine hydroxylase gene . . ^^^ |
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| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18848 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
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