| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.64193266 |
| Functional interactions between C / EBP , Sp 1 , and COUP TF regulate human immunodeficiency virus type 1 gene transcription in human brain cells . 0.64193266^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| PU . 1 ( Spi 1 ) and C / EBP alpha regulate expression of the granulocyte macrophage colony stimulating factor receptor alpha gene . ^^^ Point mutations of either the PU . 1 site or the C / EBP site that abolish the binding of the respective factors result in a significant decrease of GM CSF receptor alpha promoter activity in myelomonocytic cells only . ^^^ These results suggest that PU . 1 and C / EBP alpha direct the cell type specific expression of GM CSF receptor alpha , further establish the role of PU . 1 as a key regulator of hematopoiesis , and point to C / EBP alpha as an additional important factor in this process . . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The promoter region contains several consensus sequences where known or putative liver specific ( C / EBP , HNF 5 ) or lymphoid specific ( Pu . 1 , ets 1 ) transcription factors may bind . . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The murine neutrophil elastase gene 100 bp 5 ' flanking sequences contain several functional elements , including potential binding sites for PU . 1 , C / EBP , c Myb , and PEBP2 / CBF . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Function of PU . 1 ( Spi 1 ) , C / EBP , and AML 1 in early myelopoiesis : regulation of multiple myeloid CSF receptor promoters . ^^^ Our studies of the promoters of the myeloid CSF receptors ( M , GM , and G ) in cell lines have led to the findings that the promoters are small , and are all activated by the PU . 1 and C / EBP proteins . ^^^ Myeloid genes expressed later during differentiation , such as CD11b , are also activated by PU . 1 , which is expressed at highest levels in mature myeloid cells , but not by C / EBP alpha , which is downregulated in a differentiated murine myeloid cell line . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| PU . 1 ( Spi 1 ) and C / EBP alpha regulate the granulocyte colony stimulating factor receptor promoter in myeloid cells . ^^^ These results reinforce the importance of both PU . 1 and C / EBP alpha in the expression of myeloid specific genes and neutrophil development . . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| C / EBP , c Myb , and PU . 1 cooperate to regulate the neutrophil elastase promoter . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| PU . 1 , AML1B , and C / EBP alpha expression profiles and their relationship to cytokine receptor expression in maturing granulocytes could be distinguished from similar profiles in monocytic cells . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Consensus sequences for transcription factor binding sites including PU . 1 , AP 1 , AP 2 , C / EBP and SP 1 were present , but no classical TATA elements or initiator motifs were evident at relevant positions . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Analyses of specific nucleotide substitutions further indicated that the Tax induced transcriptional activation requires two transcription factor binding motifs within the IL1B promoter ; one is a binding site for nuclear factor ( NF ) IL 6 ( CCAAT / enhancer binding protein beta , C / EBP beta ) , which belongs to the basic region leucine zipper ( bZIP ) family and the other for Spi 1 ( PU . 1 ) , which is an Ets family protein found principally in monocytes , macrophages , and B lymphocytes . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Other transcription factor binding motifs , including c / EBP , NF kB , PU . 1 , PEA 3 , Myo D , and E2A , were observed in the 5 ' flanking sequence . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| We further show that PU . 1 has to cooperate with C / EBP proteins to induce beta c transcription . ^^^ Since the beta c is already expressed on CD34+ cells , these results demonstrate that both C / EBP and PU . 1 are not only important for the myeloid specific gene regulation at later stages of myeloid differentiation . . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Differential activity of the 2 . 7 kb chicken lysozyme enhancer in macrophages of different ontogenic origins is regulated by C / EBP and PU . 1 transcription factors . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| A 91 bp MBN promoter region containing PU . 1 , C / EBP , and c Myb binding sites is responsive to G CSF treatment . ^^^ Although PU . 1 , C / EBP , and c Myb transcription factors all were critical for expression of MBN , its up regulation by G CSF was associated mainly with PU . 1 . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Protein expression and constitutive phosphorylation of hematopoietic transcription factors PU . 1 and C / EBP beta in acute myeloid leukemia blasts . ^^^ We examined the expression and phosphorylation status of hematopoietic transcription factors PU . 1 and C / EBP beta detected by the retarded mobility of the phosphorylated forms of the proteins . ^^^ The expression of C / EBP beta and PU . 1 were detectable in 77 % and 61 % , respectively , of 90 AML samples examined . ^^^ The expressed PU . 1 and C / EBP beta was always accompanied with both phosphorylated and unphosphorylated forms of PU . 1 and C / EBP beta , respectively . ^^^ PU . 1 and C / EBP beta were simultaneously detected in all M 0 , M 4 , M 5 and peripheral blood monocytes , whereas in M 2 and M 3 , the expression of the 2 transcription factors varied among samples . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The Hoxa 9 immortalized progenitor exhibited a promyelocytic transcriptional profile , expressing PU . 1 , AML 1 , c Myb , C / EBP alpha , and C / EBP epsilon as well as their target genes , the receptors for GM CSF , G CSF , and M CSF and the primary granule proteins myeloperoxidase and neutrophil elastase . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Sequencing also revealed potential cis acting elements for multiple transcription regulators including Sp 1 , GATA , C / EBP , AP 1 , and Pu 1 . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| A 250 bp region we refer to as the fms intronic regulatory element ( FIRE ) , which is even more highly conserved than the c fms proximal promoter , contains many consensus binding sites for macrophage expressed transcription factors including Sp 1 , PU . 1 , and C / EBP . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| In agreement with that , the wild type 5 Myb induces high expression of myeloid factors C / EBP beta , PU . 1 , and Egr 1 in its target cells , whereas SCL , GATA 1 , and c Myb are more abundant in cells expressing the 5 Myb LZR mutant . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Reciprocal roles for CCAAT / enhancer binding protein ( C / EBP ) and PU . 1 transcription factors in Langerhans cell commitment . ^^^ PU . 1 and CCAAT / enhancing binding protein ( C / EBP ) family transcription factors have been characterized as key regulators for the development and function of the myeloid system . ^^^ On the other hand , expression of wild type PU . 1 in myeloid progenitors triggered LC development in the absence of TNFalpha , and its instructive effect was canceled by coexpressed C / EBP . ^^^ Our findings establish reciprocal roles for C / EBP and PU . 1 in LC development , and provide new insight into the molecular mechanism of LC development , which has not yet been well characterized . . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Genomic DNA from 381 cancers and cell lines representing leukemias , lymphomas and a variety of solid tumors were examined for mutations of genes coding for the C / EBP beta , C / EBP alpha , PU . 1 , and AML 1 transcription factors using single strand conformation polymorphism ( SSCP ) and direct DNA sequencing . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| PU . 1 : GATA 1 interaction and C / EBP suppression of FOG transcription inhibits erythroid and megakaryocyte gene expression . c Jun : PU . 1 , ICSBP : PU . 1 , and perhaps Maf : Jun complexes induce monocytic genes . ^^^ Higher levels of PU . 1 are required for monopoiesis than for B lymphopoiesis , and higher C / EBP levels may favor granulopoiesis over monopoiesis . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Expression patterns of genes encoding transcription factors ( four members of the C / EBP family , GATA 1 , GATA 2 , PU . 1 , CBFbeta , SCL , and c myb ) in EML were examined and were consistent with the proposed functions of these proteins in hematopoietic differentiation . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| These results indicate as with other myeloid genes , a relatively small segment of DNA can direct tissue specific expression , but unlike other myeloid promoters , no critical PU . 1 or C / EBP sites were found . . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The eosinophil specific P 2 promoter of the MBP gene contains GATA 1 , C / EBP , and PU . 1 consensus sites that bind these factors in nuclear extracts of the eosinophil myelocyte cell line , AML14 . 3D10 . ^^^ In vitro mutational analyses of the MBP P 2 promoter showed that both the GATA 1 / PU . 1 synergy , and repressor activity of C / EBPepsilon ( 27 ) are mediated via protein protein interactions through the C / EBP and / or GATA binding sites but not the PU . 1 sites . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The putative promoter region of LRG was found to contain consensus binding sites for PU . 1 , C / EBP , STAT , and MZF 1 . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C / EBP epsilon and PU . 1 . ^^^ The expression of MBP was inefficiently induced by C / EBP epsilon alone and weakly induced with C / EBP epsilon and GATA 1 , but the addition of PU . 1 resulted in a striking cooperative induction of MBP in NIH 3T3 cells . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The promoter sequence contained consensus binding sites for several known factors , and specific binding of nuclear PU . 1 , Sp 1 , Sp 3 , USF , AML 1 , and C / EBP proteins was detectable in gel shift assays . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| CCAAT / enhancer binding protein ( C / EBP ) alpha and PU . 1 are required for myelopoiesis . ^^^ Examination of the murine PU . 1 promoter revealed several potential C / EBP binding sites . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| In contrast , C / EBPalphap30 bound the C / EBP sites in the PU . 1 or GR gene with 3 6 fold reduced affinity . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The present study analyzed the expression of the following 13 TFs : AML 1 , CEBPA , E2A , ETS 1 , GATA 1 , GATA 2 , GATA 3 , IKAROS , IRF 1 , PAX 5 , PU 1 , TBET and TCF 1 in 7 malignant NK cell lines together with 5 malignant NKT cell lines , 5 T cell acute lymphoblastic leukemia ( ALL ) cell lines including 3 gamma / delta T cell receptor ( TCR ) type and 2 alpha / beta TCR type , and 3 B cell precursor ( BCP ) leukemia cell lines . ^^^ CEBPA , PAX 5 and PU 1 were negative for all cell lines tested except in the three positive BCP cell lines . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| At the molecular level , the expression of CAAT enhancer binding protein ( C / EBP ) epsilon , alpha and PU . 1 was substantially lower in the CD11b ( + ) cells from the bone marrow of IRF 1 ( / ) mice as compared to cells from wild type mice . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| CCAAT / enhancer binding protein ( C / EBP ) alpha , PU . 1 , granulocyte colony stimulating factor receptor , PR 3 , C / EBP epsilon and lactoferrin were sequentially expressed during neutrophil differentiation but rapidly down regulated during the early erythroid stages . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The proximal promoter of the human cathepsin G gene conferring myeloid specific expression includes C / EBP , c myb and PU . 1 binding sites . ^^^ Further deletions revealed three major regulatory regions containing the consensus binding sites for the transcription factors C / EBP , c myb and PU . 1 . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Multiple cis acting sequences to which nuclear proteins bind have been mapped , and transcription factors that can bind to these sequences have been identified ; these include C / EBP alpha , Sp 1 , USF , HNF 1 , CTF / NF1 , the glucocorticoid receptor , and RAR alpha . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that three of these sites bind C / EBP , SP 1 , and USF ( or related factors ) , respectively ; the fourth site binds a factor that we denote TF 5 beta . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Several potential binding sites for transcription factors such as C / EBP , Sp 1 , AP 1 , HNF 5 , and UPE were observed and they may be responsible for the regulation of GLUT 2 gene expression . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The 161 minimal promoter contained consensus Sp 1 and CCAAT / enhancer binding protein ( C / EBP ) motifs . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The CD 5 5 ' flanking region lacks a consensus TATA box but contains Sp 1 , AP 1 , IgH muE 2 , SV 40 enhancer core , CCAAT , TCF 2 alpha / PEA3 / ets , and C / EBP motifs . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Among the four transcription factors that bind to the human hsp 70 promoter , the DNA binding activities of three ( C / EBP , GBP , and HSF 1 ) were normal , while Sp 1 showed reduced binding activity in mitotic cell extracts . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| In all these clones , the tTA trans activator not only modulates the activity of the luciferase gene , but also modulates the activity of a number of endogenous proteins , including C / EBP beta , the glucocorticoid receptor ( GR ) , and SP 1 . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| A similar effect was observed for Sp 1 , another Zn finger transcription factor , whereas no difference was observed for the C / EBP transcription factor , which is known to be unaffected by redox changes in vitro . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Analysis of transacting factors by gel retardation assay revealed that HNF 1 , COUP TF and SP 1 were detected at almost the same level in the hepatic nuclear fraction of jvs mice as in normal littermates , and C / EBP and CREB were a little higher in jvs mice , suggesting that these factors are probably not targets of jvs mutation causing abnormal gene expression in the liver . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Previously , we have identified two adjacent C / EBP binding elements just upstream from these Sp 1 binding regions . ^^^ We now demonstrate by both in vivo and in vitro analyses that C / EBP and Sp 1 bind to the alpha 1 AGP promoter and transactivate the expression of this gene in an independent manner . . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Sequence analysis of the 5 ' flanking region has shown several potential transcription regulatory sequences , including a TATA box , a C / EBP motif , two AP 2 sites , three SP 1 sites , two NF kappa B sites , a CRE motif and an Ets 1 site . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Possible regulation of the expression of the insulin receptor gene by hormones such as insulin and dexamethasone and some transcription factors including Sp 1 and C / EBP have been shown at the mRNA and transcription levels . . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Binding activity of other nuclear factors that recognize the SP 1 and c / EBP motifs of the human TNF promoter is not affected by such treatment . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| A novel cis acting element controlling the rat CYP2D5 gene and requiring cooperativity between C / EBP beta and an Sp 1 factor . ^^^ C / EBP beta alone was unable to directly bind the 83 to 112 region of the promoter but was able to produce a ternary complex when combined with HepG 2 nuclear extracts or recombinant human Sp 1 . ^^^ A poor C / EBP binding site is present adjacent to the Sp 1 site , and mutagenesis of this site abolished formation of the ternary complex with the CYP2D5 regulatory region . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| This region contains the following regulatory elements : nitrogen regulatory / oxygen sensing consensus sequences , 5 ' TTTTGCA and 5 ' CCCTGCA ; tissue specific regulatory elements , including binding sites for A activator , 5 ' GTGGTGCAA ; for DBP , 5 ' TGATTTTGT ; for HNF , 5 ' T ( A / G ) TTTGT ; and for C / EBP , 5 ' T ( T / G ) ( T / G ) TGCAAT ; a lymphokine responsive element , 5 ' GTGAAACCCC ( Rev ) , as well as binding sites for AP and Sp 1 . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Nuclear matrix association of multiple sequence specific DNA binding activities related to SP 1 , ATF , CCAAT , C / EBP , OCT 1 , and AP 1 . ^^^ Competition analysis shows that each probe interacts with different nuclear matrix proteins in a sequence specific manner and that DNA binding activities related to or identical with SP 1 , ATF , CCAAT , C / EBP , OCT 1 , and AP 1 are present in the nuclear matrix fraction of different cell types . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Several other well characterized and purified transactivators ( c Fos , c Jun , C / EBP , AP 2 , and Sp 1 ) have been shown to bind to the 221 / +33 region . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| AP 1 , AP 2 , C / EBP , NF 1 , OCT 1 / OTF 1 , PEA 3 , Sp 1 , glucocorticoid , and thyroid hormone receptors ) , some of which may participate in the chronic regulation of this gene . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| There are differences in the affinity with which some proteins are bound to altered sites including C / EBP sites , USF / MLTF sites , and the G3T site ( which binds Sp 1 ) . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Transcription factor binding sites such as Sp 1 , PEA 3 , C / EBP , CREB , E4F1 and Pu boxes were identified in the 5 ' flanking regions of the exon 1a transcript , and Sp 1 , NF kB and PEA 3 binding sites in the 5 ' flanking region of the exon 1b transcript . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The p 53 effect was shown to be mediated by C / EBP and Sp 1 transcription factors . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Recent studies have found that several different liver enriched transcription factors including HNF 1 alpha , HNF 3 , HNF 4 , and C / EBP beta , and the more ubiquitously expressed factors Sp 1 , GABP alpha / beta , and NF2d9 are responsible for governing the transcription of P 450 genes . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| A mutant herpes simplex virus type 1 , termed delta Tfi , with a 350 bp deletion of the Sp 1 , NF kappaB , TAATGARATs , C / EBP and F 2 DNA binding elements from 420 to 70 relative to the transcriptional start site of ICPO ( Vmw 110 ) , was generated and characterized . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Sp 1 and C / EBP related factor regulate the transcription of human Cu / Zn SOD gene . ^^^ Analyses by DNase 1 footprinting and electrophoretic mobility shift assay ( EMSA ) showed that Sp 1 binds to the region from nt 104 to 89 and C / EBP related factors to the region from nt 64 to 55 . ^^^ Studies using two mutant versions of this promoter , in which the Sp 1 and C / EBP related factor binding sites were deleted , respectively , revealed that Sp 1 and C / EBP related factors activate the transcription of SOD 1 gene . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The 5 ' flanking region of the PECAM 1 gene lacks a consensus TATA box , but contains consensus motifs for Sp 1 , EGR 1 , ets , helix loop helix ( HLH ) box , GATA , AP 2 , C / EBP , YY 1 , CCACC , LyF 1 , imperfect octamer , heptamer , high mobility group proteins ( HMG ) box , and nuclear factor kappaB , as well as shear stress , retinoic acid , glucocorticoid , and acute phase responsive elements , and an Alu sequence . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Analysis of the promoter region of the rat ACBP gene by electrophoretic mobility shift assay ( EMSA ) revealed specific binding of proteins from rat liver nuclear extracts to potential recognition sequences of NF 1 / CTF , Sp 1 , AP 1 , C / EBP and HNF 3 . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The flanking region of the BST 1 gene contained several potential binding sites for nuclear factors , NF kappa B , p 53 , NF IL 6 , CREB , PEA 3 , E2A , C / EBP , AP 3 , AP 2 and SP 1 and consensus sequences for gamma IRE and ISRE like element . . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| A sequence analysis detected clusters of potential transcription factor binding sites in regions that are hypersensitive for DNase 1 , including sites for Sp 1 , HNF 3 and elements related to binding of members from the C / EBP family . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The ability of C / EBP beta but not C / EBP alpha to synergize with an Sp 1 protein is specified by the leucine zipper and activation domain . ^^^ We previously showed that liver specific transcription of the CYP2D5 gene is dictated by a proximal promoter element , termed 2D5 , that is composed of a binding site for Sp 1 or a related factor , and an adjacent cryptic C / EBP ( CCAAT / enhancer binding protein ) site . ^^^ In addition , activation of the 2D5 promoter by C / EBP beta is completely dependent on the presence of the Sp 1 site . ^^^ Using Drosophila cells that lack endogenous Sp 1 activity , we show that the serine / threonine and glutamine rich activation domains A and B of Sp 1 are required for efficient cooperatively with C / EBP beta . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The pp 52 promoter contains an initiator specifying the unique 5 ' terminus of pp 52 mRNA , tandem pairs of Ets and SP 1 motifs , and a lone C / EBP motif . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Transcriptional activity induced by liver enriched transactivators such as hepatocyte nuclear factor 3 ( HNF 3 ) , C / EBP , or HNF 4 was repressed by ARP 1 / COUP TFII independent of the presence of its cognate binding site , while basal transcription or transcriptional activity induced by ATF or Sp 1 was not perturbed by the protein . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The promoter region of the mouse gene contains various cis acting elements , including a TATA like box and a GC box as well as potential binding sites for the transcription factors NF IL 6 , MyoD , GATA , C / EBP , AP 2 , NF kappaB , AP 1 , and Sp 1 . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| CD11c integrin expression is restricted to myeloid cells and activated B lymphocytes , mainly through the collaborative action of Sp 1 and members of the AP 1 and C / EBP transcription factor families on the proximal region of the CD11c gene promoter . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The 5 ' flanking region contains potential binding sites for TATA binding protein , Sp 1 , nuclear factor 1 ( NF 1 ) , CAAT box binding protein ( C / EBP ) , hepatocyte nuclear factors 1 and 5 ( HNF 1 , HNF 5 ) and activator proteins 1 and 2 ( AP 1 , AP 2 ) . . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Instead , several putative transcriptional factor binding sites for C / EBP , PEA 3 , AP 2 , NF Y , Sp 1 , c Myc , GATA 1 , AP 1 , 5 Myb , and CREB were detected . ^^^ Functional analysis of promoter activity of the 5 ' flanking region of cyclin D 2 suggested that the region 1 , 100 to 805 including C / EBP , PEA 3 , AP 2 , NF Y , c Myc , and Sp 1 may have a major positive regulatory activity for expression of cyclin D2 . . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Substitution of the S 14 Y box in reporter genes with elements binding only NF Y elevated basal activity and T 3 mediated transactivation , whereas substitution with elements binding c / EBP related proteins or SP 1 displayed low basal activity and T 3 mediated transactivation . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| CCAAT enhancer binding proteins ( C / EBP ) regulate the tissue specific activity of the CD11c integrin gene promoter through functional interactions with Sp 1 proteins . ^^^ C / EBPalpha transactivated the CD11c promoter through the CEBP 80 element , and C / EBPalpha transactivation was also dependent on the Sp 1 70 and Sp 1 120 Sp 1 binding sites . ^^^ The 90 / 50 fragment from the CD11c promoter , containing the adjacent CEBP 80 , Sp 1 70 , and AP 1 60 sites , differentially enhanced the activity of the minimal prolactin promoter in hematopoietic and epithelial cells . ^^^ Altogether , these results demonstrate that C / EBP factors participate in the tissue restricted and regulated expression of the CD11c / CD18 integrin through functional interactions with Sp 1 , suggest that Sp 1 related factors modulate C / EBPalpha transcriptional activity on the CD11c promoter , and demonstrate the existence of a composite regulatory element recognized by C / EBP , Sp 1 , and AP 1 factors and whose enhancing effects are cell type dependent . . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| In vitro gel shifts showed that P . amarus inhibited complexing of C / EBP transcription factors to a consensus oligonucleotide sequence , whereas DNA binding of AP 1 and SP 1 transcription factors was unaffected . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The promoter region contains putative binding sites for several transcription factors , e . g . , Sp 1 , AP 2 , AP 4 , and C / EBP , but no TATA box was found . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| In a previous study , it was found that transcription factors of the Sp 1 and C / EBP family are associated with the expression of human Cu / Zn SOD [ Seo et al . ( 1996 ) . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| This region of the gene also contains consensus sequences for liver enriched transcription factors , C / EBP beta and HNF 4 , as well as for the ubiquitous protein factors , AP 1 , H4TF1 , NF 1 , and Sp 1 . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Regulation of leptin promoter function by Sp 1 , C / EBP , and a novel factor . ^^^ Mutations of the Sp 1 , LP 1 , and C / EBP sites in pairwise combinations diminished promoter activity to the extent predicted assuming these motifs contribute independently to leptin promoter function . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| These include AP 1 , AP 2 , NF kB , C / EBP , c Myc and a metal responding element identified in the promoter region , and two Sp 1 elements in intron 1 . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Data bank search revealed several cis active DNA elements ( SP 1 , CREB , C / EBP , AP 1 and AP 2 like and GATA ) in the proximal 1 . 1 kb region . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| DNA sequence analysis of the promoter revealed a number of consensus binding sites for known transcription factors such as SP 1 , AP 1 , NFkappaB , C / EBP and TFIID , and a repeat GC GT sequence motif seen for the formation of Z type DNA . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Sequence analysis reveals several consensus sequences for transcription factors including NF kappa B , C / EBP , SP 1 , and the lack of a classical TATA box . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| A role of C / EBP and Sp 1 in mediating this glucocorticoid effect was furthermore excluded . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The promoter is highly GC rich ( 75 % ) in the first 300 base pairs and contains several Sp 1 binding sites , a C / EBP , a HSF 2 , a STATx , a c Myb , several 5 Myb , and numerous GATA consensus binding sites . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| In vivo DNA footprintings of this promoter have shown that a number of potential SP 1 and C / EBP response elements are constitutively occupied in the entire quail neuroretina of E 5 and E 14 , whereas the two consensus palindromic E2F binding sites are only protected at E 5 . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Within the promoter domain , a functional CAAT box / enhancer binding protein ( C / EBP ) ( 398 ) and an Sp 1 element ( 386 ) , which bind C / EBPbeta and Sp1 / Sp3 , respectively , contribute individually to promoter activation in gonadal and non gonadal cells . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Computer assisted analysis of the nucleotide sequence revealed a number of regulatory motifs , including multiple sites for Sp 1 , C / EBP , NF Y , and USF . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The hPIII , containing identical Sp 1 and C / EBP elements as in the rodent promoters , shares 81 % similarity in the region 480 / 106 to both the rat and mouse . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Using the lacZ reporter in raft cultures , we previously showed that this transcriptional regulation of the HPV type 11 ( HPV 11 ) enhancer promoter located in the upstream regulatory region ( URR ) appears to have resulted from coordination between the transcription transactivators AP 1 , Oct 1 , and Sp 1 in differentiated upper strata and the repressor C / EBP in proliferating basal cells . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Sp 1 was shown to bind to a GC box at the 5 ' end of the C / EBP regulatory element in the C / EBPalpha promoter and , in so doing , to competitively prevent binding to and transactivation of the promoter by the C / EBPs . ^^^ This decrease in Sp 1 level early in the differentiation program appears to facilitate access of C / EBPbeta and / or C / EBPdelta to the C / EBP regulatory element and , thereby , derepression of the C / EBPalpha gene . . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The basal promoter region contains potential binding sites for several transcription factors including SP 1 , AP 2 , C / EBP , LF A 1 , and E box , which may be responsible for ubiquitous , but liver and kidney preferred tissue expression of the hepsin gene . . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| These include NF kappaB , C / EBP , YY 1 , AP 2 , SAF and Sp 1 . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The human MMP 2 promoter contains potential cis acting regulatory elements including cAMP response element binding protein , AP 1 , AP 2 , PEA 3 , C / EBP , and Sp 1 . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The sequence of 3 . 18 kb upstream of exon 1 reveals numerous consensus transcription factor binding sites , some of which were shown to be important in the positive and negative control of Aldh3a1 gene expression ; these include seven aromatic hydrocarbon response elements ( AHREs ) , an electrophile response element ( EPRE ) , and AP 1 , C / EBP beta , c / EBP alpha , NF kappaB , Sp 1 , and NF 1 putative binding sites . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| In contrast , Be stimulation failed to increase the levels of any transcription factor tested , NF kappaB , AP 1 , AP 2 , CREB , C / EBP , Sp 1 , Egr 1 , Ets , NF Y or Oct 1 , in 12j cells . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Sp 1 and C / EBP are necessary to activate the lactoferrin gene promoter during myeloid differentiation . ^^^ The presence of a C / EBP site flanked by 2 Sp 1 sites within this segment of the LF promoter prompted us to investigate the possible role of these sites in LF expression . ^^^ Electrophoretic mobility shift assays found that the C / EBP site is recognized by C / EBPalpha and that both LF Sp 1 binding sites bind the Sp 1 transcription factor specifically in myeloid cells . ^^^ Taken together , these observations indicate a functional interaction between C / EBP and Sp 1 in mediating LF expression . ( Blood . 2000 ; 95 : 3734 3741 ) . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Several consensus elements for transcription factors , including AP 1 , C / EBP , and Sp 1 are phylogenetically conserved between pig and human , while AP 3 and PEA 3 are found only in pig . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The rat promoter contained no classical TATA or CAAT boxes but putative binding sites for the transcription factors C / EBP , GATA 1 , HNF 1 , HNF 3beta , SP 1 , and USF . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| StAR gene expression is regulated primarily at the transcriptional level , and the roles of transcription factors that govern basal and cAMP dependent StAR expression including SF 1 , C / EBP beta , Sp 1 and GATA 4 are reviewed . . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Although deletion of either the C / EBP or the Sp 1 site drastically reduced the xC / EBPalpha promoter activity , multimers of only the C / EBP site could confer autoregulation to a heterologous SV 40 promoter . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Individual mutations of C / EBP and Sp 1 sites resulted in a loss of more than 50 % of the cAMP dependent induction . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The 5 ' flanking region contains putative cis elements including a TATA box , an AP 1 site , CEBP sites , Sp 1 site , and Ets binding domains . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Elements binding known transcription factors such as Sp 1 , Pit 1 , CCAAT enhancer binding protein ( C / EBP ) , glucocorticoid receptor and hypoxia inducible factor 1 ( HIF 1 ) were also identified . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| We have examined binding of the CREB B ZIP protein domain to double stranded DNA containing a consensus CRE sequence ( 5 ' TGACGTCA 3 ' ) , the related PAR , C / EBP and AP 1 sequences and the unrelated SP 1 sequence . ^^^ The CREB CRE complex had an apparent Kd of approximately 300 pM , PAR of approximately 1 nM , C / EBP and AP 1 of approximately 3 nM and SP 1 of approximately 30 nM . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Both putative promoter sequences were TATA less , CAAT less , contained highly GC rich sites , and had multiple putative regulatory cis elements ( e . g . , AP 1 , AP 2 , C / EBP , SP 1 , NF 1 , and GATA ) . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| A approximately 3 kb 5 ' flanking region upstream from the putative transcription start site of the gene contained consensus Sp 1 and CCAAT / enhancer binding protein ( C / EBP ) motifs , and transient transfection assay with secreted alkaline phosphatase reporter confirmed the promoter activity in 3T3 L 1 cells that possessed expression of the cotransfected C / EBP alpha expression plasmid . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| In contrast , using SP 1 and C / EBP constructs , reporter gene activity was not altered . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The promoter region lacks a TATA box but contains potential binding sites for the transcriptional factors including SP 1 , E2F , c Myc , C / EBP and NFkappaB . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Within this sequence we identified putative binding sites for Sp 1 , nuclear factor Y ( NF Y ) , activator protein 2 ( ' AP 2 ' ) , CCAAT / enhancer binding protein ( ' C / EBP ' ) and E2F transcription factors . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| TF 1 cells were shown to contain the transcription factors C / EBP , Sp 1 , and NF kappaB . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| These factors include those previously known to be involved in PTH signaling ( AP 1 and the cAMP response element binding protein ) , those that were identified by microarray data ( C / EBP ) , and some novel transcription factors ( AP 2 , AP 4 , SP 1 , FoxD 3 , etc . ) . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Remarkably , after 8 h , C / EBP , CREB , AP 2 , and Sp 1 binding activities were greatly depleted relative to both naive and corresponding vehicle controls . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| A nucleoprotein complex containing Sp 1 , C / EBP beta , and HMGI Y controls human insulin receptor gene transcription . ^^^ Here we provide evidence that transcriptional activation of the human IR promoter requires the assembly of a transcriptionally active multiprotein DNA complex which includes , in addition to HMGI Y , the ubiquitously expressed transcription factor Sp 1 and the CCAAT enhancer binding protein beta ( C / EBP beta ) . ^^^ Functional integrity of this nucleoprotein complex is required for full transactivation of the IR gene by Sp 1 and C / EBP beta in cells readily expressing IRs . ^^^ We show that HMGI Y physically interacts with Sp 1 and C / EBP beta and facilitates the binding of both factors to the IR promoter in vitro . ^^^ Repression of HMGI Y function adversely affects both Sp 1 and C / EBP beta induced transactivation of the IR promoter . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| By site directed mutagenesis , we found that disruption at both the Sp 1 and C / EBP binding sites almost completely blocked the LPS response . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| A number of transcription factors such as Sp 1 , C / EBP ( CCATT / enhancer binding protein ) , and CREB seem to be involved in the transcriptional control of arginase 1 and may contribute to the complex expression pattern of arginase 1 in distinct brain regions and during development . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Transcriptional regulation of the human reduced folate carrier promoter C : synergistic transactivation by Sp 1 and C / EBP beta and identification of a downstream repressor . ^^^ By gel shift and chromatin immunoprecipitation assays , Sp 1 and C / EBP beta transcription factors were found to bind consensus elements ( GC box , CCAAT box ) within this region . ^^^ The functional importance of these elements was confirmed by transient tranfections of HepG 2 cells with hRFC C reporter constructs in which these elements were mutated , and by co transfections of Drosophila SL 2 cells with wild type hRFC C promoter and expression constructs for Sp 1 and C / EBP beta . ^^^ Whereas both Sp 1 and C / EBP beta transactivated hRFC C promoter activity , C / EBP alpha and gamma were transcriptionally inert . ^^^ Sp 1 combined with C / EBP beta resulted in a synergistic transactivation . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Within this sequence we identified putative binding sites for C / EBP and Sp 1 . ^^^ Cotransfection assays demonstrated that C / EBP transcription factors modulated the basal and tissue specific activity of the Mrp 3 gene promoter by recognition of the C / EBP ( 157 / 140 ) element and through functional cooperation with factors interacting with the Sp 1 ( 3 ) and Sp 1 ( 4 ) ( 140 / 106 ) cis acting elements . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| In the present study , we cloned the promoters of GnRH 1 , GnRH 2 , and GnRH 3 genes in the tilapia , Oreochromis niloticus ; and found putative binding sites for glucocorticoid receptors , Sp 1 , C / EBP , GATA , and Oct 1 , but not for androgen receptors in all three GnRH promoters using computer analysis . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| These studies suggest that AP 1 , Sp 1 , and C / EBP transcription factors are required for appropriate differentiation dependent involucrin expression , and that the mechanism of regulation is similar in most surface epithelia . . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| DNaseI footprint analysis revealed seven protected regions and electrophoretic mobility shift , super shift and competition assays identified individual DNA protein complexes capable of binding Sp 1 , estrogen receptor ( ER ) alpha , glucocorticoid receptor and CCAAT enhancer binding protein ( C / EBP ) gamma transcription factors . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| The abolition of the E ( 2 ) effect by mutation of Sp 1 or C / EBP elements that bind Sp1 / Sp3 and C / EBPbeta within PIII indicated the cooperation of these transfactors in E ( 2 ) induced transcription of the hPRLR . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| In the present study , to investigate whether the C / EBP family would be involved in the regulation of surfactant proteins , we examined the protein expression of SP A , and SP C , and mRNA expression of SP A , SP B , and SP C in the lungs from newborn C / EBPalpha deficient mice . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| Members of the C / EBP transcription factor family stimulate expression of the human and rat surfactant protein A ( SP A ) genes . ^^^ In contrast to control plasmids , C / EBP delta expressing plasmids reversed the action of a transcriptional silencer just upstream of the rat SP A promoter . ^^^ In order to test the effect of C / EBPs on endogenous SP A gene expression , cells that express SP A were exposed to a phosphorothioate substituted , double stranded oligonucleotide matching the consensus C / EBP binding site ( decoy oligonucleotide ) at concentrations from 0 . 5 to 10 microM for 72 h . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| A role for C / EBP delta in human surfactant protein A ( SP A ) gene expression . ^^^ We detected C / EBP delta mRNA and protein in NCI H 441 cells , a cell line derived from a human adenocarcinoma that produces surfactant protein A ( SP A ) . ^^^ After exposure to the oligonucleotides , cells were harvested , total RNA prepared , and levels of mRNA for C / EBP delta , SP A and a control , glyceraldehyde 3 phosphate dehydrogenase ( GAPDH ) , were quantified from Northern blots . ^^^ The loss of C / EBP delta was accompanied by a decrease in the level of SP A mRNA . ^^^ We conclude that C / EBP delta plays a role in the regulation of SP A gene expression . . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| As studied in the explants from fetal and newborn lung , the SP A mRNA expression additionally associated with C / EBPdelta mRNA and with the binding of nuclear extracts from the lung explants to the C / EBP consensus probe . ^^^ |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17947 and P49715 |
Pubmed |
SVM Score :0.0 |
| NA |
|