| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Appearance of CaM KII subunits immunoreactive to anti phosphorylated Y 66 antibody paralleled the generation of Ca ( 2+ ) independent kinase activity . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We have examined the mechanism of this action by using a new , highly specific , peptide inhibitor of Ca2+ / calmodulin dependent protein kinase 2 ( CaMKII ) as well as other kinase inhibitors and show that the muscarinic block of gK ( Ca ) relies on CaMKII activation in both CA 1 and CA 3 neurons . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca2+ / calmodulin dependent autophosphorylation of a specific threonine residue ( alpha Thr 286 ) within the autoinhibitory domain generates partially Ca ( 2+ ) independent CaMKII activity . ^^^ This Ca ( 2+ ) independent autophosphorylation is very rapid following prior Ca2+ / calmodulin dependent autophosphorylation at alpha Thr 286 and generates constitutively active , Ca2+ / calmodulin insensitive CaMKII activity . ^^^ Ca ( 2+ ) independent autophosphorylation of CaMKII also occurs at a slower rate when alpha Thr 286 is not autophosphorylated and results in inactivation of CaMKII . ^^^ Thus , Ca ( 2+ ) independent autophosphorylation of CaMKII generates a form of the kinase that is refractory to activation by Ca2+ / calmodulin . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| To clarify the details of the involvement of Ca ( 2+ ) calmodulin in gating of C 1 channels , effects of a novel calmodulin dependent protein kinase 2 ( CaMK 2 ) inhibitor , KN 62 , on C 1 current and C 1 efflux induced by serotonin ( 5 HT ) were investigated in Xenopus oocyte injected with rat brain mRNA . 5 HT evoked inward current on voltage clamp condition at 60 mV in a concentration dependent manner . ^^^ These results suggest that CaMK 2 is activated by Ca ( 2+ ) calmodulin and opens Cl channels to induce CL efflux in Xenopus oocytes . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| KN 93 elicited potent inhibitory effects on CaMKII phosphorylating activity with an inhibition constant of 0 . 37 microM but this compound had no significant effects on the catalytic activity of cAMP dependent protein kinase , Ca2+ / phospholipid dependent protein kinase , myosin light chain kinase and Ca ( 2+ ) phosphodiesterase . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| To assess the involvement of protein kinases in the Ca dependent stimulation of Cl conductance , we employed pseudosubstrate peptide inhibitors of protein kinase C ( PKC ) and the Ca / CaM dependent protein kinase 2 ( CaMKII ) . ^^^ In contrast , stimulation of GCl ( Ca ) by ionomycin was abolished when pipette solutions contained 10 microM CaMKII peptide inhibitor CaMKII ( 273 302 ) . ^^^ The truncated peptide CaMKII ( 284 302 ) ( 20 microM ) lacks the CaMKII inhibitory domain and did not affect GCl ( Ca ) . ^^^ These data suggest that CaM , acting through the multifunctional CaMKII , mediates the Ca dependent stimulation of Cl conductance in colonic secretory cells . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| To test the involvement of Ca2+ / calmodulin dependent kinase 2 ( CaM K 2 ) , truncated , constitutively active form of this kinase was directly injected into CA 1 hippocampal pyramidal cells . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Calcium and CaMKII dependent chloride secretion induced by the microsomal Ca ( 2+ ) ATPase inhibitor 2 , 5 di ( tert butyl ) 1 , 4 hydroquinone in cystic fibrosis pancreatic epithelial cells . ^^^ Pretreatment of monolayers of CFPAC 1 cells with DBHQ for 4 5 min significantly increased the Ca ( 2+ ) independent or autonomous activity of CaMKII assayed in the cell homogenates . ^^^ Thus , DBHQ appears to enhance Cl channel activity via a Ca ( 2+ ) dependent mechanism involving CaMKII . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| This study analyzed the ability of the N methyl D aspartate receptor antagonist dextrorphan ( DX ) to prevent neuronal degeneration ( analyzed by light microscopy ) , calmodulin ( CaM ) redistribution ( analyzed by immunocytochemistry ) and changes in activity of two major Ca ( 2+ ) dependent protein kinases calcium / calmodulin dependent protein kinase 2 ( CaM KII ) and protein kinase C ( PKC ) ( analyzed by specific substrate phosphorylation ) after 20 min of global ischemia ( four vessel occlusion model ) in rats . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Mice expressing the mutant form of the kinase show an increased level of Ca ( 2+ ) independent CaMKII activity similar to that seen following LTP . ^^^ The regulation of this frequency response function by Ca ( 2+ ) independent CaMKII activity seems to account for two previously unexplained synaptic phenomena , the relative loss of LTD in adult animals compared with juveniles and the enhanced capability for depression of facilitated synapses . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We assessed hippocampal dependent memory in mice with a Ca ( 2+ ) independent form of CaMKII generated by the introduction of an aspartate at amino acid 286 . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca ( 2+ ) activated Cl current ( ICl , Ca ) in colonic T 84 cells is inhibited by the specific peptide inhibitor of Ca2+ / calmodulin dependent kinase 2 ( CaM KII ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We investigated the effect of Ca ( 2+ ) and phospholipid dependent protein kinase C ( PKC ) and Ca2+ / calmodulin dependent protein kinase 2 ( CaMK 2 ) on Na ( + ) and Cl ( ) dependent proline transport across the rat renal brush border membrane ( BBM ) . ^^^ Bioassays utilizing selective peptide substrates for Ca ( 2+ ) dependent protein kinases demonstrated the presence of PKC and CaMK 2 in the BBM . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Role of Ca2+ / CaMK 2 in Ca ( 2+ ) induced K+ channel inhibition in rat CCD principal cell . ^^^ In the present study , we used the patch clamp technique to examine the role of Ca2+ / calmodulin dependent protein kinase 2 ( CaMK 2 ) in mediating the Ca ( 2+ ) induced inhibitory effect . ^^^ It is concluded that CaMK 2 is involved in mediating the Ca ( 2+ ) induced inhibition of the activity of the apical K+ channel of rat CCD . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We investigated the role of Ca / calmodulin dependent protein kinase ( CaMKII ) in relaxation and cytosolic free [ Ca ] ( [ Ca ] 1 ) decline during steady state ( SS ) and postrest ( PR ) twitches in intact rat ventricular myocytes . ^^^ We conclude that CaMKII plays a major role in modulation of relaxation in rat ventricular myocytes , enhancing SR Ca uptake in a activity dependent fashion . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The channel protein , which migrates with an M ( r ) of 140 , 000 under nonreducing conditions , is phosphorylated in vitro by CaMK 2 in a Ca ( 2+ ) and calmodulin dependent manner . ^^^ Addition of CaMK 2 to the presumptive cytoplasmic side of the bilayer in the presence of ATP and calmodulin dramatically increased the sensitivity of the channel to free Ca2+ , shifting the dose response curve for Ca ( 2+ ) dependent channel activation to lower [ Ca2+ ] 1 , the maximum increase in channel Po occurring between 0 . 6 and 1 microM . ^^^ These observations suggest that a novel Ca ( 2+ ) sensitive anion channel isolated from bovine airway epithelium is regulated by CaMK 2 phosphorylation . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| This Ca ( 2+ ) induced shift is mediated by calmodulin dependent protein kinase 2 ( CaMKII ) , because it is abolished by inhibitors of CaMKII but not of protein kinase C and is subsequently restored by exogenous calmodulin . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of the sarcoplasmic reticulum ( SR ) protein phospholamban by adenosine 3 ' , 5 ' cyclic monophosphate ( cAMP ) dependent protein kinase ( PKA ) and Ca calmodulin dependent protein kinase ( CaM KII ) stimulates Ca adenosinetriphosphatase ( ATPase ) activity and SR Ca transport , but the role of CaM KII dependent phosphorylation is not well defined . ^^^ We studied the PKA and CaM KII dependent regulation of SR Ca transport in digitonin permeabilized rabbit ventricular myocytes . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The ICa staircase was completely abolished by dialysis with either of two inhibitory peptides of Ca calmodulin dependent protein kinase ( CaMKII ) CaMKII ( 290 309 ) and CaMKII ( 273 302 ) ] , implicating this kinase . ^^^ We conclude that the Ca dependent ICa facilitation is due to activation of CaMKII and phosphorylation of a site on or near the Ca channel . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| CCK rapidly converted Ca2+ / calmodulin kinase 2 ( CaMK 2 ) to a Ca ( 2+ ) independent form with peak action at 30 sec followed by decline to the basal level at 10 min . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The target for Ca ( 2+ ) calmodulin is thus CaM KII . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We have used mutants of these kinases and phosphatases ( gamma B * CaM K and delta CaM AI , respectively ) to explore their relative role in cytokine gene transcription and their interactions with PKC dependent signaling systems . gamma B * CaM K and delta CaM AI , known to exhibit constitutive Ca ( 2+ ) independent activity , were cotransfected ( alone or in combination ) in Jurkat T cells with a plasmid containing the intact IL 2 promoter driving the expression of the chloramphenicol acetyltransferase reporter gene . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Basal autophosphorylation resulted in inactivation of Ca2+ / calmodulin dependent kinase activity toward exogenous peptide substrate ; there was no measurable increase in Ca ( 2+ ) independent CaMKII activity . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The activation of IMCR by Ca2+ appears to be mediated by a kinase , probably the Ca ( 2+ ) and calmodulin dependent protein kinase ( CaMKII ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The regulation of the cardiac Ca2+ release channel ryanodine receptor ( RyR ) by exogenous acid phosphatase ( AcPh ) and purified Ca ( 2+ ) calmodulin dependent protein kinase 2 ( CaMKII ) was studied in swine and rabbit sarcoplasmic reticulum ( SR ) vesicles using [ 3H ] ryanodine binding and planar bilayer reconstitution experiments . 2 . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The role of several biological molecules in learning and memory are considered , for example , protein kinase C ( PKC ) , Ca ( ++ ) Calmodulin kinase 2 ( CaMKII ) , GAP 43 , and glutamate receptors . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| On cell treatment with elevated extracellular potassium ( 10 60 mM ) or angiotensin 2 , Ca ( 2+ ) independent CaMKII activity increased to 133 205 % of basal activity . ^^^ Ca ( 2+ ) independent kinase activity in agonist stimulated extracts was inhibited by the CaMKII inhibitor peptide , 1 ( ) [ N , O bis ( 1 , 5 isoquinolinesulfonyl ) N methyl L tyrosyl ] 4 phenylpiperazine ( KN 62 ) , a cell permeable inhibitor of CaMKII , reduced the agonist induced stimulation of Ca ( 2+ ) independent CaMKII activity . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| External Ca2+ electroporated into cells preloaded with the catalytic domains was quickly removed ( but not when the cells were pretreated with the endoplasmic reticulum Ca ( 2+ ) ATPase inhibitor , tapsigargin ) , indicating that the ATP driven Ca2+ pump was somehow activated by CaMK 2 . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The studies showed : ( 1 ) endogenous ( membrane bound ) CaMKII and PKC as well as exogenous , highly purified PKC inhibit proline uptake by phosphorylated , lyzed / resealed BBMV when compared with control vesicles ; the voltage clamped , nonelectrogenic component of proline transport was inhibited by PKC but not CaMKII mediated phosphorylation ; ( 2 ) a Ca ( 2+ ) dependent activity of both kinases was evident in all subcellular fractions tested in immature and adult kidneys . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The Ca2+ / calmodulin dependent protein kinase ( CaMK ) type IV / Gr is selectively expressed in T lymphocytes and is activated after signaling via the T cell antigen receptor ( TCR ) , indicating that it mediates some of the Ca ( 2+ ) dependent transcriptional events that follow TCR engagement . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Prolongation of the ischaemic period up to 5 min inhibited both Ca ( 2+ ) dependent and , to a lesser extent , Ca ( 2+ ) independent activities of CaM KII . ^^^ In effect , in spite of inhibition of total CaM KII activity , its Ca ( 2+ ) independent , persistently active component can still remain more abundant at specific membrane regions . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Incubation of muscles from alpha BuTX treated rats with K252a , a broad spectrum protein kinase inhibitor of , amongst others , PKC , Ca ( 2+ ) calmodulin dependent protein kinase 2 ( CaMKII ) and neurotrophin receptor tyrosine kinases , resulted in a 30 % decrease of the quantal content . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Neither KN 62 , a specific inhibitor of Ca ( 2+ ) calmodulin dependent protein kinase 2 ( CaMK 2 ) , nor specific inhibitors of protein phosphatase 2B ( PP2B ) , cyclosporin A and FK 506 , blocked the inhibition . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| These findings indicate that Ca ( 2+ ) dependent increases in membrane Cl permeability are related in part to opening of 14 . pS anion channels through a mechanism that depends on both Ca2+ and CaMKII . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation by adenosine 3 ' , 5 ' cyclic monophosphate ( cAMP ) dependent protein kinase ( PKA ) , but not by Ca ( ++ ) calmodulin dependent protein kinase 2 ( CaMK 2 ) , was shown earlier to protect microtubule associated protein 2 ( MAP 2 ) from cleavage by m calpain ( Johnson and Foley : J Neurosci Res 34 : 642 647 , 1993 ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The alpha subunit of Ca ( 2+ ) calmodulin dependent protein kinase 2 ( CaMKII alpha ) is one of only five mRNAs known to be present within the dendrites , as well as in the soma of neurons . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We describe a Triton insoluble cytoskeletal fraction extracted from cerebral cortex of young rats retaining an endogenous Ca ( 2+ ) mediated mechanism acting in vitro on Ca2+ / calmodulin dependent protein kinase 2 ( CaM KII ) activity and on phosphorylation and proteolysis of the 150 kDa neurofilament subunit ( NF M ) , alpha and beta tubulin . ^^^ Furthermore , exogenous Ca2+ / calmodulin induced increased in vitro phosphorylation of the cytoskeletal proteins and CaM KII activity only in the presence of calpastatin , suggesting the presence of Ca ( 2+ ) induced calpain mediated proteolysis . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| This suggested that Ca ( 2+ ) influx during dark adaption and subsequent activation of CaMKII is an important step for spinule retraction . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The effect of Ca ( 2+ ) calmodulin dependent protein kinase 2 ( CaMKII ) on excitation contraction coupling ( E C coupling ) was studied in intact ferret cardiac myocytes using the selective inhibitor KN 93 , KN 93 decreased steady state ( SS ) twitch [ Ca2+ ] 1 ( by 51 % ) , resting Ca2+ spark frequency ( by 88 % ) and SS sarcoplasmic reticulum ( SR ) Ca2+ content evaluated by eaffeine application ( by 37 . 5 % ) . 2 . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Mastoparan , a calmodulin inhibitor peptide , and a peptide corresponding to the pseudosubstrate region of mammalian calmodulin dependent protein kinase 2 ( CaMKII ( 281 302 ) ) attenuated Ca ( 2+ ) dependent phosphorylation in a dose dependent manner . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Treating the mouse intestine with the calmodulin antagonist W 7 and KN 93 , an inhibitor of Ca ( 2+ ) calmodulin dependent protein kinase 2 ( CaMK 2 ) , reduced the sensitivity of the host to the action of Escherichia coli heat stable enterotoxin 2 ( STII ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| In the presence of ATP , dialysis of the calmodulin antagonist W 7 , the Ca2+ / calmodulin dependent kinase 2 ( CaMKII ) inhibitor KN 93 , or a CaMKII specific peptide inhibitor the rate of ICl ( Ca ) decay was slowed and matched the [ Ca2+ ] 1 decline , whereas H 7 , a nonspecific kinase inhibitor with low affinity for CaMKII , was without effect . ^^^ When a sustained increase in [ Ca2+ ] 1 was produced in ATP dialyzed cells , the current decayed completely , whereas in cells loaded with 5 ' adenylylimidodiphosphate ( AMP PNP ) , KN 93 , or the CaMKII inhibitory peptide , ICl ( Ca ) did not decay . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The stimulated Ca ( 2+ ) independent activity of autophosphorylated CaMKII was reversed by the action of CaMKIIPase . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The concomitant reductions in CaMK 2 activity and Ca ( 2+ ) induced insulin secretion suggest that the activation of CaMK 2 is required for normal insulin secretory responses to increased intracellular Ca2+ concentrations . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| This effect is apparent at the single myocyte level and depends on sarcoplasmic reticulum ( SR ) Ca transport and Ca / calmodulin dependent protein kinase [ CaMKII ; see R . ^^^ Because phosphorylation of phospholamban ( PLB ) by CaMKII can stimulate SR Ca transport , it is a plausible candidate mechanism . ^^^ Furthermore , the CaMKII inhibitor KN 93 ( 1 microM ) abolished the stimulation dependent acceleration of twitch [ Ca ] 1 decline in PLB KO . ^^^ This indicates that neither PLB nor its phosphorylation are required for the CaMKII dependent acceleration of the SS twitch [ Ca ] 1 decline and relaxation . ^^^ We conclude that the PLB KO myocytes retain a CaMKII dependent acceleration of SS twitch [ Ca ] 1 decline . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The stimulation of Ca ( 2+ ) independent ( autonomous ) CaMK 2 enzymatic activity , a barometer of in situ activated CaMK 2 , was prevented by the same KN 93 concentrations that cause G 1 phase arrest . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| A computer model of CaMKII is investigated that incorporates recent findings about the geometrical arrangement of subunits , the mechanism of Ca ( 2+ ) dependent subunit activation , and Ca ( 2+ ) independent autophosphorylation . ^^^ It is demonstrated numerically that ( 1 ) CaMKII is tuned to be activated by stimulation protocols associated with the induction of long term potentiation ; ( 2 ) the observed slow dissociation of trapped Ca2+ / calmodulin may require the autonomy site to be protected from dephosphorylation ; and ( 3 ) Ca ( 2+ ) independent kinase activity is expressed in a manner akin to a graded switch . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| A role of Ca ( 2+ ) and calmodulin dependent protein kinase 2 ( CaMK 2 ) in lung surfactant secretion was evaluated using KN 62 , a specific inhibitor of CaMK 2 . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Tetanic stimulation leads to increased accumulation of Ca ( 2+ ) / calmodulin dependent protein kinase 2 via dendritic protein synthesis in hippocampal neurons . mRNA for the alpha subunit of CaMKII is abundant in dendrites of neurons in the forebrain ( Steward , 1997 ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| In the present report , we discuss three signal transduction pathways : the Ca ( 2+ ) / calmodulin dependent kinase ( CaMK ) pathway , the Ras / ERK pathway , and the SAPK pathways that might function to couple synaptic activity to long term adaptive responses , in part through the regulation of new gene expression . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Over two dozen alternative splice variants of CaMK 2 , the type 2 Ca ( 2+ ) / CaM dependent protein kinase , are encoded from four genes ( alpha , beta , gamma and delta ) in mammalian cells . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca ( 2+ ) / calmodulin dependent protein kinases 2 ( CaMKII ) have important functions in regulating cardiac excitability and contractility . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The fairly high degree of the substrate specificity of this protein phosphatase suggests that the physiological significance of the phosphatase may be the regulation of the three multifunctional Ca2+ / calmodulin dependent protein kinases , CaMKI , CaMKII , and CaMKIV , which are the key enzymes in a Ca ( 2+ ) signaling system in the cell . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Calcium / calmodulin dependent protein kinase 2 ( CaM KII ) is thought to be involved in the majority of the neuronal functions mediated by intracellular free Ca ( 2+ ) , and has been implicated in long term potentiation , learning , and memory . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Attenuation of adenylyl cyclase activity by Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) has also been proposed as a mechanism for adaptation . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Inhibition of L type Ca ( 2+ ) current facilitation by 1 microM KN 62 , a blocker of CamKII , was first demonstrated and provided evidence for functional CamKII activity in this preparation . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We show that inhibiting postsynaptic Ca2+ / CaM dependent protein kinase 2 ( CaM KII ) and Ca2+ / phospholipitidyserine dependent protein kinase ( PKC ) in hippocampal CA 1 neurons attenuates significantly the expression of LTP , but not basal synaptic transmission . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) and the phosphatase calcineurin ( CaN ) are Ca ( 2+ ) / calmodulin binding proteins that are very abundant in the central nervous system . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Chimeric proteins in which both the autoregulatory and oligomerization domains of CaM KII ( residues 281 478 ) were substituted for residues 781 972 of smMLCK , MK ( CK 281 478 ) , or only the autoregulatory domain of CaM KII ( residues 281 315 ) was exchanged for residues 781 813 of smMLCK , MK ( CK 281 315 ) , exhibited significant enzymatic activity in the absence of Ca ( 2+ ) / CaM . ^^^ In contrast , both MK and a chimeric protein in which the C terminal half of the autoregulatory domain of smMLCK was replaced with CaM KII residues 301 315 , MK ( CK 301 315 ) , were inactive in the absence of Ca ( 2+ ) / CaM . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| At constant SR Ca load and ICa in intact cells we have found that SR Ca release is increased by Ca calmodulin dependent protein kinase ( CaMKII ) and FK 506 ( which may interfere with the interaction between the Ca release channel and the FK binding protein ) and is reduced by the Ca channel agonist Bay K 8644 , CaMKII inhibitors , and during ventricular hypertrophy . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| To determine whether the Ca ( 2+ ) independent and Ca ( 2+ ) / CaM dependent forms of Ca ( 2+ ) / CaM dependent protein kinase 2 ( CaMKII ) might contribute to some of the SRF kinase activity , autocamtide 3 , a synthetic substrate that is specific for CaMKII , was employed . ^^^ While the Ca ( 2+ ) independent form of CaMKII was increased , like the Ca ( 2+ ) independent form of SRF kinase , no alteration in CaMKII occurred at 7 days of stretch overload . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The protective effects of IP on Ca ( 2+ ) paradox changes in cardiac contractile activity as well as SR Ca ( 2+ ) pump and Ca ( 2+ ) release activities were lost when the hearts were treated with 8 ( p sulfophenyl ) theophylline , an adenosine receptor antagonist ; KN 93 , a specific Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMK 2 ) inhibitor ; or chelerythrine chloride , a protein kinase C ( PKC ) inhibitor . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Multiple isoforms of type 2 Ca ( 2+ ) calmodulin dependent kinase ( CaM KII ) are composed of two major neuron specific subunits , designated alpha and beta , and two less well characterized subunits that are also expressed in non neuronal tissues , designated delta and gamma . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Although Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMK ) is known to phosphorylate different Ca ( 2+ ) cycling proteins in the cardiac sarcoplasmic reticulum ( SR ) and regulate its function , the status of CaMK in heart failure has not been investigated previously . ^^^ In this study , we examined the hypothesis that changes in the CaMK mediated phosphorylation of the SR Ca ( 2+ ) cycling proteins are associated with heart failure . ^^^ A significant depression in SR Ca ( 2+ ) uptake and release activities was associated with a decrease in SR CaMK phosphorylation of the SR proteins , ryanodine receptor ( RyR ) , Ca ( 2+ ) pump ATPase ( SR / endoplasmic reticulum Ca ( 2+ ) ATPase [ SERCA2a ] ) , and phospholamban ( PLB ) in the failing heart . ^^^ Although the SR Ca ( 2+ ) / calmodulin dependent CaMK activity , CaMK content , and CaMK autophosphorylation were depressed , the SR phosphatase activity was enhanced in the failing heart . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The basal phosphorylation state of PLB at Thr 17 in isolated SR vesicles from rabbit slow twitch muscle , colocalization of CaM K 2 with PLB and SERCA2a at the same membrane domain , and the divergent subcellular distribution of PKA , taken together , seem to argue for a differential heterogeneity in the regulation of Ca ( 2+ ) transport between such muscle and heart muscle . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) undergoes Ca ( 2+ ) / calmodulin dependent autophosphorylation of threonine 286 / 287 ( Thr ( 286 / 287 ) ) . ^^^ Extremely high concentration of CaMKII in the postsynaptic spine indicates that increase in the Ca ( 2+ ) concentration in the spine induced by synaptic activation results in Thr ( 286 / 287 ) autophosphorylation of this enzyme . ^^^ It has recently been shown that the K ( d ) value of CaMKII for Ca ( 2+ ) / calmodulin ( Ca ( 2+ ) / CaM ) drastically decreases after Thr ( 286 / 287 ) autophosphorylation . ^^^ Therefore , Ca ( 2+ ) / CaM associated with CaMKII becomes tightly bound to this kinase after Thr ( 286 / 287 ) autophosphorylation . ^^^ CaMKII undergoing Thr ( 286 / 287 ) autophosphorylation in each spine is eager to recruit nearby calmodulin in the dendrite for Ca ( 2+ ) / CaM trapping . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The SOC influx stimulated by the hormone was insensitive to both CAM antagonists ( fluphenazine , trifluoperazine , chlorpromazine , compound 48 / 80 ) and the CAM dependent protein kinase 2 ( CAMKII ) inhibitor KN 62 when added after the sterol dependent Ca ( 2+ ) transient , but it was completely abolished when added prior to the IP ( 3 ) induced mobilization of Ca ( 2+ ) from endogenous stores . ^^^ The present results suggest that the 1 , 25 ( OH ) ( 2 ) D ( 3 ) induced ( IP ( 3 ) mediated ) cytosolic Ca ( 2+ ) transient is required for CAM , activation which in turn activates SOC influx in a mechanism that seems to include CAMKII . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Here we show that kainate receptors expressed in cultured hippocampal neurons can be modulated by Ca ( 2+ ) / calmodulin dependent phosphatase ( calcineurin ) and Ca ( 2+ ) / calmodulin dependent kinase ( CaMK ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| These results demonstrate that c fos activation by hypoxia involves CaMK activation and CREB phosphorylation at Ser 133 and requires Ca / CRE and SRE . ^^^ Immunoblot analysis revealed Ca ( 2+ ) / calmodulin dependent kinase 2 ( CaMKII ) protein in PC 12 cells and revealed that hypoxia increased the enzyme activity . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Additional studies using Ca ( 2+ ) activated kinases indicate that Ca ( 2+ ) / TEF / TEFRE regulated transcription may be mediated through Ca ( 2+ ) / calmodulin dependent kinase ( CaMK ) 4 . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We characterized the activity of Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) in homogenates and nuclear extracts of skeletal muscle and analyzed their capacity to phosphorylate the myogenic factor SRF . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Measurements of Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMK 2 ) enzyme activity and immunoreactivity in permeabilized islets demonstrated Ca ( 2+ ) induced reductions in enzyme activity which could not be attributed to reductions in CaMK 2 immunoreactive protein . ^^^ Measurements in intact islets demonstrated that the Ca ( 2+ ) induced reduction of CaMK 2 activity was also operative in intact cells , suggesting that this mechanism may have pathophysiological implications for beta cell function . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Since targets of this Ca ( 2+ ) release could play a role in Wnt signaling , we first tested the hypothesis that Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CamKII ) is activated by some Wnt and Frizzled homologs . ^^^ We report that Wnt and Frizzled homologs that activate Ca ( 2+ ) release and PKC also activate CamKII activity in Xenopus embryos , while Wnt and Frizzled homologs that activate beta catenin function do not . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| A novel particulate form of Ca ( 2+ ) / calmodulin dependent [ correction of Ca ( 2+ ) / CaMKII dependent ] protein kinase 2 in neurons . ^^^ Cytoskeletal and postsynaptic density ( PSD ) fractions from forebrain contain discrete spherical structures that are immunopositive for Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) . ^^^ On the other hand , clustering would not affect the ability of the large cellular pool of CaMKII to act as a calmodulin sink , as demonstrated by the Ca ( 2+ ) dependent binding of gold conjugated calmodulin to CaMKII clusters . ^^^ We propose that the observed clustering of CaMKII into spherical structures is a protective mechanism preventing excessive protein phosphorylation upon loss of Ca ( 2+ ) homeostasis , without compromising calmodulin regulation . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Similarly , the beta MHC promoter was activated by Ca ( 2+ ) ionophores and a protein kinase C activator . beta MHC promoter activation induced by ET 1 was suppressed by pretreatment with the calmodulin inhibitor , W 7 , the Ca ( 2+ ) / calmodulin dependent kinase 2 ( CaMKII ) inhibitor , KN 62 , and the calcineurin inhibitor , cyclosporin A . beta MHC promoter activation by ET 1 was also attenuated by overexpression of dominant negative mutants of CaMKII and calcineurin . ^^^ These results suggest that Ca ( 2+ ) plays a critical role in ET 1 induced cardiomyocyte hypertrophy by activating CaMKII and calcineurin dependent pathways . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Inhibition of Ca ( 2+ ) / calmodulin dependent kinase 2 ( CaMKII ) completely blocks the acute effect of NT 3 . ^^^ Thus , NT 3 potentiates neurotransmitter secretion by stimulating Ca ( 2+ ) release from intracellular stores through IP 3 and / or ryanodine receptors , leading to an activation of CaMKII . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Distribution of Ca ( 2+ ) / calmodulin dependent protein kinase phosphatase ( CaM K Pase ) which dephosphorylate multifunctional Ca ( 2+ ) / calmodulin dependent protein kinases ( CaM kinases ) in the rat brain and spinal cord were examined immunohistochemically by using an antibody against this enzyme . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Both Ser ( 16 ) and Thr ( 17 ) of phospholamban ( PLB ) are phosphorylated , respectively , by cAMP dependent protein kinase ( PKA ) and Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We also show that KN 62 , a specific inhibitor of Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) suppressed depolarization mediated survival in a does dependent manner ( IC ( 50 ) = approximately 2 microM ) that paralleled attenuation of sustained levels of intracellular Ca ( 2+ ) evoked by depolarization . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Although Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMK 2 ) is known to modulate the function of cardiac sarcoplasmic reticulum ( SR ) under physiological conditions , the status of SR CaMK 2 in ischemic preconditioning ( IP ) of the heart is not known . ^^^ The beneficial effects of IP on the I / R induced changes in contractile activity and SR Ca ( 2+ ) pump were lost upon treating the hearts with KN 93 , a specific CaMK 2 inhibitor . ^^^ IP also prevented the I / R induced depression in Ca ( 2+ ) / calmodulin dependent SR Ca ( 2+ ) uptake activity and the I / R induced decrease in the SR CaMK 2 activity ; these effects of IP were blocked by KN 93 . ^^^ The results indicate that IP may prevent the I / R induced alterations in SR Ca ( 2+ ) handling abilities by preserving the SR CaMK 2 activity , and it is suggested that CaMK 2 may play a role in mediating the beneficial effects of IP on heart function . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| In contrast , the synaptic clustering of Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) alpha , another core component of the PSD , was completely dependent on an intact actin cytoskeleton and was partially disrupted by detergent . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The beta subunit of human Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( beta CaMKII ) was identified by searching through an expressed sequence tag database and rapid amplification of cDNA 5 ' ends and was assigned to chromosome 7 . ^^^ When expressed in HEK 293 cells , the Ca ( 2+ ) / calmodulin dependent kinase activity of beta 7 , the shortest variant , was much lower than that of either beta ( the longest one ) or betae ( the medium one ) , suggesting possible regulation of beta CaMKII activity by alternative splicing . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Calmodulin dependent protein kinase 2 ( CaMKII ) is a ubiquitous , multifunctional enzyme family involved in the regulation of a variety of Ca ( 2+ ) signaling pathways . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We have previously demonstrated that Ca ( 2+ ) / calmodulin dependent protein kinase ( CaMK ) mediates pyrimidinoceptor potentiation of LPS elicited inducible nitric oxide synthase ( iNOS ) induction in murine J 774 macrophages . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Intracellular injection of either calmodulin binding domain ( 100 micrometer ) or Ca ( 2+ ) / calmodulin kinase 2 ( CaMKII ) inhibitor 281 301 ( 10 micrometer ) blocked the depolarization induced facilitation . ^^^ These results suggest that increases in [ Ca ( 2+ ) ] ( 1 ) cause persistent facilitation of spike backpropagation in the apical dendrite of CA 1 pyramidal neuron by CaMKII dependent mechanisms . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Thus , our results indicate that Ca ( 2+ ) triggers cross talk signal transduction between CaM kinase and NO and CaM K IIalpha phosphorylating nNOS on Ser ( 847 ) , which in turn decreases the gaseous second messenger NO in neuronal cells . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Inhibitors of phospholipase C ( PLC ) , protein kinase C ( PKC ) , Ca ( 2+ ) / calmodulin dependent protein kinase ( CaMK ) and antagonists of the L type Ca ( 2+ ) channel also inhibit the corticosterone induced gene transcription . 6 . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We have recently shown that the substitution of two putative Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMK 2 ) phosphorylation sites , S 261 and S 266 , by alanines in the third intracellular loop of the rat mu opioid receptor ( rMOR 1 ) confers resistance to CaMK 2 induced receptor desensitization . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Some Cl ( Ca ) channels are blocked by Ca ( 2+ ) calmodulin dependent protein kinase ( CAMKII ) inhibitors . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses , and studies over the past two to three years have identified key functions for Ca ( 2+ ) / calmodulin dependent protein kinases 2 and 4 ( CaM KII and CaM KIV ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Here we developed a method to visualize the activities of Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) in the cytoplasm , plasma membrane , and nucleus , separately , by utilizing targeted phosphorylation motifs and phosphorylation specific antibodies . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Our data suggest that activation of CaMKII by carbachol is crucial for local theta like activity in the CA 1 area of the rat hippocampus in vitro . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| SCaM 4 required 4 fold higher [ Ca ( 2+ ) ] for half maximal activation of CaM KII , and 1 . 5 fold higher [ Ca ( 2+ ) ] for activation of cyclic nucleotide phosphodiesterase than SCaM 1 . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca ( 2+ ) / calmodulin dependent protein kinase 2 expression pattern in adult mouse heart and cardiogenic differentiation of embryonic stem cells . delta isoforms of the Ca ( 2+ ) / calmodulin dependent protein kinase type 2 ( CaMKII ) are considered to substantially influence cardiac functions . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Moreover , inhibition of Ca ( 2+ ) / calmodulin dependent kinase 2 ( CaMKII ) significantly reduced the effectiveness of the tetanic stimulation . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Modulation of sarcoplasmic reticulum ( SR ) Ca ( 2+ ) transport by endogenous calmodulin dependent protein kinase 2 ( CaM K 2 ) involves covalent changes of regulatory protein phospholamban ( PLB ) , as a common , but not the only mechanism , in limb slow twitch muscles of certain mammalian species , such as the rabbit . ^^^ Accommodating embryological heterogeneity in the paradigm of neural dependent expression of specific isogenes in skeletal muscle fibers , our results provide novel evidence for the differential expression in the SR of 72 kDa beta components of CaM K 2 , together with the expression of a slow twitch sarcoendoplasmic reticulum Ca ( 2+ ) ATPase isoform , both in limb muscle and in the masseter . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| These deficits were accompanied by a decreased basal level of the activated Ca ( 2+ ) / CaM dependent kinase 2 ( CaMKII ) ( approximately 60 % of wild type ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| A role for Ca ( 2+ ) calmodulin dependent kinase ( CamK ) in regulation of the voltage sensitive release mechanism ( VSRM ) was investigated in guinea pig ventricular myocytes . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The present study utilized patch clamp and fura 2 fluorescence techniques to assess the involvement of multifunctional calcium calmodulin kinase 2 ( CAMKII ) in the BK ( Ca ) feedback response . ^^^ In cell attached patches , KN 62 ( specific inhibitor of CAMKII ) either abolished or reduced to near zero the ANG 2 induced BK ( Ca ) feedback response . ^^^ In inside out patches ( 1 microM Ca ( 2+ ) in bath ) , calmodulin plus ATP activated BK ( Ca ) channels in the presence but not the absence of CAMKII . ^^^ These observations are consistent with the postulate that CAMKII is involved in the BK ( Ca ) feedback response of mesangial cells , acting to potentiate the influence of increased [ Ca ( 2+ ) ] ( 1 ) on the BK ( Ca ) channel or a closely associated regulator of the channel . ^^^ An additional effect of CAMKII to activate a voltage gated Ca ( 2+ ) channel can not be ruled out by these experiments . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| This study demonstrates , for the first time , that active CaM KII silences Ca ( 2+ ) sensitive nuclear signaling cascades for transcriptional up regulation of cardiomyocyte hypertrophy . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The aim of the present study was to investigate the possible causal relationship between protein kinase activity and the induction of the vestibular compensation process , by delivering inhibitors of protein kinase C ( PKC ) or Ca ( 2+ ) / calmodulin dependent kinase 2 ( CaMKII ) into the ipsilateral VNC at the time of the UVD and determining their effects on three static symptoms of UVD , spontaneous nystagmus ( SN ) , yaw head tilt ( YHT ) and roll head tilt ( RHT ) in guinea pigs . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Genetic analysis shows that UNC 43 , the C . elegans Ca ( 2+ ) / calmodulin protein kinase 2 ( CaMKII ) , controls locomotion rate . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| PP 1 inhibition seems to promote the activation of Ca ( 2+ ) / calmodulin dependent protein kinase ( CaMKII ) , because ( 1 ) a CaMKII inhibitor blocked the induction of LTP by TPS paired with either isoproterenol or activated inhibitor 1 and ( 2 ) CaMKII in area CA 1 was activated by the combination of TPS and 8 Br cAMP but not by either stimulus alone . ^^^ These results indicate that the cAMP pathway enables TPS induced LTP by inhibiting PP 1 , thereby enhancing Ca ( 2+ ) independent CaMKII activity . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| A mathematical model is presented of autophosphorylation of Ca ( 2+ ) / calmodulin dependent protein kinase ( CaMKII ) and its dephosphorylation by a phosphatase . ^^^ If the total concentration of CaMKII subunits is significantly higher than the phosphatase Michaelis constant , two stable steady states of the CaMKII autophosphorylation can exist in a Ca ( 2+ ) concentration range from below the resting value of the intracellular [ Ca ( 2+ ) ] to the threshold concentration for induction of long term potentiation ( LTP ) . ^^^ Ca ( 2+ ) transients that switch CaMKII from the low phosphorylated state to the high phosphorylated one are in the same range of amplitudes and frequencies as the Ca ( 2+ ) transients that induce LTP . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Here we report that SA node pacemaker activity is critically dependent on Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) . ^^^ To understand the ionic mechanisms of the CaMKII effects , we measured L type Ca ( 2+ ) current ( 1 ( Ca , L ) ) , which contributes both to AP upstroke and to pacemaker depolarization . ^^^ Similar results were observed using the fast Ca ( 2+ ) chelator BAPTA , whereas the slow Ca ( 2+ ) chelator EGTA had no significant effect , which suggests that CaMKII activity is preferentially regulated by local Ca ( 2+ ) transients . ^^^ Thus , we conclude that CaMKII plays a vital role in regulating cardiac pacemaker activity mainly via modulating 1 ( Ca , L ) inactivation and reactivation , and local Ca ( 2+ ) is critically involved in these processes . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was to investigate whether LIF activates Ca ( 2+ ) dependent signaling molecules , such as calcineurin and calmodulin kinases 2 and 4 ( CaMKII and CaMKIV ) , and , if so , whether these Ca ( 2+ ) mediated signaling events contribute to LIF mediated cardiac hypertrophy . ^^^ These findings indicated that LIF activated CaMKII , CaMKIV , and calcineurin through an increase in 1 : ( Ca , L ) and [ Ca ( 2+ ) ] ( 1 ) and that CaMKII , CaMKIV , and calcineurin are critically involved in LIF induced cardiac hypertrophy . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The synthetic peptide inhibitors of CaM kinase 2 , [ Ala ( 286 ) ] CaMK 281 302 and AIP ( autocamtide 2 related inhibitory peptide ) , strongly inhibited Ca ( 2+ ) induced insulin secretion from electropermeabilized islets , an effect that also correlated with an equivalent inhibition of CaM kinase 2 activation . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The effect of Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) stimulation on unitary low voltage activated ( LVA ) T type Ca ( 2+ ) channel currents in isolated bovine adrenal glomerulosa ( AG ) cells was measured using the patch clamp technique . ^^^ Preincubation of AG cells with lipophilic or peptide inhibitors of CaMKII in the cell attached or excised ( inside out ) configurations prevented the rise in NP ( o ) elicited by elevated Ca ( 2+ ) concentration . ^^^ These data indicate that CaMKII activity is both necessary and sufficient for LVA channel activation by Ca ( 2+ ) . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMK 2 ) has been linked to the induction of differentiation in preneuronal cells . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Regulatory phosphorylation of phospholamban and of SR Ca ( 2+ ) ATPase SERCA2a isoform by endogenous CaM K 2 in slow twitch skeletal and cardiac sarcoplasmic reticulum ( SR ) is well documented , but much less is known of the exact functional role of CaM K 2 in fast twitch muscle SR . ^^^ That raises the question of whether CaM K 2 mediated phosphorylation of alpha KAP and triadin together might be involved in a molecular signaling pathway important for SR Ca ( 2+ ) release in fast twitch muscle SR . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| To elucidate the signal pathway ( s ) for the activation of Ca ( 2+ ) / calmodulin dependent protein kinase ( CaMKII ) we studied Thr 17 phosphorylation of phospholamban in dependence of Ca ( 2+ ) channel activation by S ( ) Bay K 8644 and in dependence of the depletion of the sarcoplasmic reticulum Ca ( 2+ ) stores by ryanodine or thapsigargin in the absence or presence of beta adrenergic stimulation . ^^^ In summary , our results reflect a cross talk between beta adrenoceptor stimulation and intracellular Ca ( 2+ ) at the level of CaMKII mediated phospholamban phosphorylation in neonatal rat cardiomyocytes . ^^^ We postulate that Ca ( 2+ ) transport systems of the sarcoplasmic reticulum are critical determinants for the activation of CaMKII that catalyzes phosphorylation of phospholamban . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The aims of this study were to investigate the involvement of ionotropic glutamate receptors , especially those of the NMDA subtype , and the requirement for Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) in these phenomena . ^^^ It is suggested that these effects of intracellular Ca ( 2+ ) on the maintenance phase of the in vitro kindling like state and EPSP spike potentiation are mediated by CaMKII dependent mechanisms . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| In this study , we analyzed in forebrain homogenates from female Sprague Dawley rats the activities of extracellular signal regulated kinase 1 / 2 ( ERK1 / 2 ) , c Jun NH ( 2 ) terminal kinase ( JNK ) , glycogen synthase kinase 3beta ( GSK 3beta ) , cyclin dependent kinase 5 ( Cdk 5 ) , cAMP dependent protein kinase A ( PKA ) , and Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) at 0 ( n = 5 ) , 3 ( n = 4 ) , 6 ( n = 5 ) , and 12 ( n = 5 ) h after heat shock and in non heat shocked controls ( n = 5 ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca dependent stimulation of the sodium pump by K ( o ) and Ca ( o ) was inhibited by isradipine ( 10 microM ) , a blocker of L and T type calcium channels , by compound 48 / 80 ( 40 microg / ml ) and calmidizolium ( 10 microM ) , which inhibits calmodulin ( CaM ) , and by KN 62 ( 10 microM ) , which blocks some forms of Ca / CaM kinase 2 ( CaMKII ) . ^^^ The resulting increase in [ Ca ( 2+ ) ] ( 1 ) may stimulate the sodium pump by activating CaM and / or CaMKII . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Here we report the identification of the alpha subunit of Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) and alpha actinin 4 as potential binding partners for the densin 180 intracellular segment . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Previous studies showed that the type 2 Ca ( 2+ ) / calmodulin and cAMP dependent protein kinases ( CaMKII and PKA ) are affected by long term antidepressant treatment in presynaptic and somatodendritic compartments , respectively . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We tested the hypothesis that defective activation of the Ca ( 2+ ) dependent effector proteins calmodulin ( CaM ) and CaM dependent protein kinase 2 ( CaMKII ) contributes to the intracellular pathogenesis of tuberculosis . ^^^ Furthermore , ionophore induced elevations in [ Ca ( 2+ ) ] ( c ) resulted in recruitment of CaM and activation of CaMKII on phagosomes containing live M . tuberculosis . ^^^ Specific inhibitors of CaM or CaMKII blocked Ca ( 2+ ) ionophore induced phagosomal maturation and enhanced the bacilli ' s intracellular viability . ^^^ These results demonstrate a novel role for CaM and CaMKII in the regulation of phagosome lysosome fusion and suggest that defective activation of these Ca ( 2+ ) activated signaling components contributes to the successful parasitism of human macrophages by M . tuberculosis . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Based on experimental and computational results , we discuss how elevated theta ( M ) may be related to ( 1 ) reduced levels of neurotransmitters modulating plasticity , ( 2 ) abnormally low expression of N methyl d aspartate receptors ( NMDARs ) , and ( 3 ) the membrane translocation of Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) in adult rat cortex subjected to prenatal alcohol exposure . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| In the presence of Ca ( 2+ ) , B . emersonii CaM exhibited a shift in apparent molecular mass similar to that observed with bovine CaM and was able to activate the autophosphorylation of CaM dependent protein kinase 2 ( CaMKII ) from rat brain . ^^^ The Ca ( 2+ ) channel blocker TMB 8 and the CaMKII inhibitor KN 93 completely inhibited sporulation if added up to 60 min after induction of this stage , but only KN 93 affected fungal growth . ^^^ The data presented suggest that the Ca ( 2+ ) CaM complex and CaMKII play an important role during growth and sporulation in B . emersonii . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Genetic analysis shows that activated Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) is suppressed by perturbations of this network , which include loss of the GOA 1 G ( o ) alpha , DGK 1 diacylglycerol kinase , EAT 16 G protein gamma subunit like ( GGL ) containing RGS protein , or an unidentified protein encoded by the gene eat 11 [ 9 ] . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| In whole cell recordings , both Ca ( 2+ ) and CaMKII dependent mechanisms contributed to chloride channel stimulation by Ca ( 2+ ) , but the CaMKII dependent pathway was selectively inhibited by inositol 3 , 4 , 5 , 6 tetrakisphosphate ( Ins ( 3 , 4 , 5 , 6 ) P ( 4 ) ) . ^^^ This inhibitory effect of Ins ( 3 , 4 , 5 , 6 ) P ( 4 ) on Cl ( Ca ) channel stimulation by CaMKII was reduced by raising [ Ca ( 2+ ) ] and prevented by inhibition of protein phosphatase activity with 100 nm okadaic acid . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Thus we were unable to demonstrate a functional role of persistent Ca ( 2+ ) independent CaMKII activity in LTP maintenance . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) and the cAMP dependent protein kinase A ( PKA ) cascades have been implicated in neural mechanisms underlying learning and memory as supported by mutational analyses of the two enzymes in Drosophila . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The conditioned taste aversion ( CTA ) paradigm was used to assess the role of Ca ( 2+ ) / calmodulin dependent protein kinase ( CAMKII ) in associative learning . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The Ca ( 2+ ) signals that produced only rapid CaMK signaling to pCREB or both rapid CaMK and slow MAPK signaling deviated significantly for only approximately 1 min , yet their differential impact on pCREB extended over a much longer period , between 20 and 60 min and beyond , which is of likely significance for gene expression . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Calmodulin kinase ( CaMK ) has characteristics suitable for an ECC coordinating molecule : it is activated by Ca ( 2+ ) / calmodulin , it regulates LTCC and RyR , and it is enriched in the vicinity of LTCC and RyR . ^^^ Intact cardiomyocytes were studied under conditions where CaMK activity could be controlled independently of intracellular Ca ( 2+ ) by using an engineered Ca ( 2+ ) independent form of CaMK and a highly specific CaMK inhibitory peptide . ^^^ CaMK reciprocally enhanced L type Ca ( 2+ ) current and reduced release of Ca ( 2+ ) from the SR while increasing SR Ca ( 2+ ) content . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca ( 2+ ) independent , functional CAMKII activity was considerably increased in hippocampus but decreased in neocortex of GPAS rats in comparison with Wistar ones . ^^^ Daily repeated audiogenic seizures induced the decrease of Ca ( 2+ ) independent CAMKII activity in hippocampus and the increase of PKA activity in neocortex of AGPAS rats in comparison with GPAS ones . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The differential expression of CaMKK beta isoforms with distinct activity further suggests the complexity of the regulation of the CaMKK / CaMK cascade and an important role for CaMKK in the action of Ca ( +2 ) mediated cellular responses . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The results are compared with the metaphase blocking effects of the noble gas xenon , where the xenon induced block can be overcome by small intracellular increases of Ca ( 2+ ) , thus indicating the CaM K 2 system as a possible target for xenon . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Although CREB has many putative kinases for its phosphorylation , such as p 38 mitogen activated protein kinase ( p 38 MAPK ) , Ca ( 2+ ) / calmodulin dependent protein kinase Pi ( CaMK Pi ) and protein kinase C ( PKC ) , we found the protein kinase A ( PKA ) was activated and its activation peaked when cells were treated for 60 min ( with arbitrary activity unit of 11 . 03+ / 2 . 80 and 0 . 86+ / 0 . 43 in treatment and control , respectively ) , this phasic character was similar to that of the CREB phosphorylation . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The characteristics and regulation by Ca ( 2+ ) calmodulin dependent kinase 2 ( CaMKII ) were compared between the three cell types . 2 . ^^^ The CaMKII inhibitor KN 93 ( 5 microM ) increased the amplitude of 1 ( Cl ( Ca ) ) in PA and CA myocytes . ^^^ Cell dialysis with constitutively active CaMKII ( 30 nM ) significantly reduced 1 ( Cl ( Ca ) ) evoked by 500 nM Ca ( 2+ ) . 4 . ^^^ The present study shows that regulation of Ca ( 2+ ) dependent Cl ( ) channels by CaMKII differs between arterial and portal vein myocytes . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| This study was designed to identify the role of a recently identified Ca ( 2+ ) / calmodulin dependent protein kinase ( CaMK ) like kinase ( CaMKLK ) in neuronal apoptosis . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| In addition , Ca ( 2+ ) CaM ( 40 : 10 microM ) induced synaptic potentiation , which occluded PS induced potentiation and was attenuated by introducing CaMKII ( 281 301 ) ( 100 microM ) . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| By contrast , the application of Ca ( 2+ ) / calmodulin kinase 2 ( CaMK 2 , 300 pM ) dramatically increased this channel activity in inside out patches . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Thin section immunoelectron microscopy of hippocampal cultures indicates that at least part of the observed thickening of PSDs can be accounted for by an accumulation of Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) on their cytoplasmic faces . ^^^ In cultures , glutamate induced thickening of PSDs and the accumulation of CaMKII on PSDs are reversed within 5 min of removal of glutamate and Ca ( 2+ ) from the extracellular medium . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) inhibitor KN 93 and inhibitor peptides abolished the effects of phenylephrine on IK 1 . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMK 2 ) isozyme variability is the result of alternative usage of variable domain sequences . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Activation of mitogen activated protein kinase ( MAPK ) and Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) are required for numerous forms of neuronal plasticity , including long term potentiation ( LTP ) . ^^^ The increases in MAPK and CaMKII phosphorylation were strongly colocalized in the dendrites and cell bodies of CA 1 pyramidal cells , and both the transient phosphorylation and delayed expression of CaMKII were prevented by inhibiting p42 / p44 MAPK . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca2+ calmodulin dependent protein kinase 2 ( CaMK ) and a calmodulin ( CaM ) binding ' IQ ' domain ( IQ ) are both implicated in Ca2+ dependent regulation of L type Ca2+ current ( 1 ( Ca ) ) . ^^^ We used an IQ mimetic peptide ( IQmp ) , under conditions in which CaMK activity was controlled , to test the relationship between these CaM activated signalling elements in the regulation of L type Ca2+ channels ( LTCCs ) and 1 ( Ca ) in rabbit ventricular myocytes . 2 . ^^^ A specific CaMK inhibitory peptide nearly abolished 1 ( Ca ) facilitation , but the facilitation was ' rescued ' by cell dialysis with IQmp . 3 . ^^^ These findings support the hypothesis that CaMK is required for physiological 1 ( Ca ) facilitation in cardiac myocytes . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Autonomous activation of calcium calmodulin kinase ( CaMKII ) has been proposed as a molecular mechanism for decoding Ca ( 2+ ) spike frequencies resulting from action potential firing , but this has not been investigated in intact neurons . ^^^ This was studied in mouse DRG neurons in culture using confocal measurements of [ Ca ( 2+ ) ] ( 1 ) and biochemical measurements of CaMKII autophosphorylation and autonomous activity . ^^^ Frequency dependent activation of CaMKII was limited to spike frequencies in the range of 0 . 1 1 Hz , despite marked increases in [ Ca ( 2+ ) ] ( 1 ) at higher frequencies ( 1 30 Hz ) . ^^^ The high levels of autonomous activity measured before stimulation and the relatively long duration of Ca ( 2+ ) spikes induced by action potentials ( approximately 300 msec ) are consistent with the lower frequency range of action potential decoding by CaMKII . ^^^ CaMKII autonomous activity in response to brief bursts of action potentials correlated better with the frequency of Ca ( 2+ ) transients than with the concentration of [ Ca ( 2+ ) ] ( 1 ) . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The results suggest that CaMKII is anchored to skeletal muscle RyRs and that phosphorylation by this kinase alters the enhancement of channel activity by ATP and Ca ( 2+ ) . . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The response to S100A12 was abolished by inhibitors of phospholipase C ( PLC ) , protein kinase C ( PKC ) , Ca ( 2+ ) flux , Ca ( 2+ ) / calmodulin dependent kinase 2 ( CaMKII ) or mitogen activated protein kinase kinase ( MEK ) . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Calmodulin dependent protein kinase phosphatase ( CaMKP ) dephosphorylates and concomitantly deactivates multifunctional Ca ( 2+ ) / calmodulin dependent protein kinases ( CaMKs ) , such as CaMKI , CaMKII , and CaMKIV . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Conceptually , this is of particular importance for second messenger regulated protein kinases with a broad spectrum of substrates , such as the serine / threonine protein kinases PKA , PKC , and CaMKII ( cyclic AMP dependent protein kinase , Ca ( 2+ ) phospholipid dependent protein kinase , and Ca ( 2+ ) / calmodulin dependent protein kinase 2 ) . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Furthermore , genistein , a tyrosine kinase inhibitor , blocked the P2X ( 7 ) R activated PLD , while KN 62 , a Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) inhibitor , was less effective , whereas the mitogen activated protein kinase ( MAPK ) inhibitor PD 98059 was ineffective . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Treatment of cultured hippocampal neurons with the mitochondrial uncoupler carbonyl cyanide m chlorophenylhydrazone ( CCCP ) in the absence of glucose mimics ischemic energy depletion and induces formation of Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) clusters , spherical structures with diameters of 75 175 nm [ Dosemeci et al . , J . ^^^ The appearance of immunolabeled CaMKII clusters , detected by electron microscopy , follows the onset of the sustained increase in intracellular Ca ( 2+ ) . ^^^ Moreover , CaMKII does not cluster when the rise in intracellular Ca ( 2+ ) is prevented by the omission of extracellular Ca ( 2+ ) during CCCP treatment , confirming that clustering is Ca ( 2+ ) dependent . ^^^ A lag period of 1 2 min between the onset of high intracellular Ca ( 2+ ) levels and the formation of CaMKII clusters suggests that a sustained increase in Ca ( 2+ ) level is necessary for the clustering . ^^^ These results indicate that pathological conditions that promote sustained episodes of Ca ( 2+ ) overload result in a transitory clustering of CaMKII into spherical structures . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The delta isoform of Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) predominates in the heart . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Here we show that the apoptosis correlates with protein phosphorylation events and can be blocked by protein kinase inhibitors directed against the multifunctional Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Protein kinase C ( PKC ) and Ca ( 2+ ) calmodulin dependent protein kinase 2 ( CaMKII ) have been implicated in isoflurane increased force in skinned femoral arterial strips . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) is thought to be activated during the cholinergic stimulation of gastric acid secretion . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Here we investigate the regulation of Ca ( 5 ) 3 . 2 alpha ( 1 ) subunits ( alpha1H ) by calcium and / or calmodulin dependent protein kinase 2 ( CaMKII ) . 293 cells stably expressing alpha1H were transiently transfected with CaMKIIgamma ( C ) . ^^^ Under identical conditions , CaMKII activation did not regulate the activity of Ca ( 5 ) 3 . 1 channels , the first cloned member ( alpha1G ) of the T type Ca ( 2+ ) channel family . ^^^ Our results provide the first evidence for the differential regulation of two members of the Ca ( 5 ) 3 family by protein kinase activation and the first report reconstituting CaMKII dependent regulation of any cloned Ca ( 2+ ) channel . . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Multifunctional Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) is highly enriched at synapses and has been implicated in regulating the formation and function of several sensory systems , including the visual and the somatosensory systems . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Because SR function is regulated by phosphorylation of phospholamban ( PLB ) , a SR protein phosphorylated by cAMP dependent protein kinase ( PKA ) at Ser ( 16 ) and Ca ( 2+ ) calmodulin dependent protein kinase ( CaMKII ) at Thr ( 17 ) , the phosphorylation of these residues during ischemia and reperfusion was examined in Langendorff perfused rat hearts . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| In this study we provide evidence for the interaction of projectin with the calcium sensor Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Inhibition of Ca ( 2+ ) / CaM kinase ( CaM K ) slowed the current decay , the rate of entry into inactivation , and shifted the voltage dependence of hH 1 in the depolarizing direction independent of CaM overexpression with no effect on micro 1 Na ( + ) channels . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Enzymatic assays gave evidence for the presence of Ca ( 2+ ) / CaM dependent protein kinase 2 ( CaMKII ) in plasma membranes from rat jejunum . ^^^ However , uptake experiments suggest that Ca ( 2+ ) / CaM , and not CaMKII , inhibits both basolateral Cl ( ) / HCO ( 3 ) ( ) exchange and H ( + ) lactate symport , whilst HCO ( 3 ) ( ) and Cl ( ) conductances are unaffected . ^^^ Neither Ca ( 2+ ) / CaM nor CaMKII seem to regulate brush border Na ( + ) / H ( + ) exchanger activity . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Multiple signaling pathways ( PKA , PKC , and Ca ( 2+ ) / CaMKII ) contribute to the HCO ( 3 ) ( ) transport in cultured corneal endothelium . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The caffeine induced increases in GLUT 4 and MEF2A and MEF2D were partially blocked by dantrolene , an inhibitor of sarcoplasmic reticulum Ca ( 2+ ) release , and completely blocked by KN 93 , an inhibitor of Ca ( 2+ ) calmodulin dependent protein kinase ( CAMK ) . ^^^ The data suggest that this effect of Ca ( 2+ ) is mediated by activation of CAMK and indicate that MEF2A and MEF2D are involved in this adaptive response . . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Activation by carbachol of endogenously expressed M ( 1 ) muscarinic receptors in human embryonic kidney 293 cells , induced the internalization of mGluR 1 splice variants , which was partially blocked by pretreatment with inhibitors of either PKC or Ca ( 2+ ) calmodulin dependent kinase 2 ( CaMKII ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The enzyme Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) is widely distributed in the nervous system . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We confirmed that inhibition of Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) or PKA suppresses RP . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| METHODS : Human CAMK2G was cloned from a total human P 1 artificial chromosome library using a partial Ca ( 2+ ) / calmodulin dependent protein kinase gamma ( E ) cDNA probe . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Some forms of activity dependent synaptic potentiation require the activation of postsynaptic Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Highly enriched in brain tissue and present throughout the body , Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) is central to the coordination and execution of Ca ( 2+ ) signal transduction . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Calcium / calmodulin dependent protein kinase 2 ( CaMKII ) is thought to be a critical mediator of neuronal plasticity that links transiently triggered Ca ( 2+ ) signals to persistent changes in neuronal physiology . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| A Ca ( 2+ ) / calmodulin dependent protein kinase ( CaMK ) gene was cloned and characterized from Arthrobotrys dactyloides , a nematode trapping fungus . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca ( 2+ ) / calmodulin ( CaM ) dependent protein kinase 1 ( CaM KI ) , which is a member of the multifunctional CaM K family , is thought to be involved in various Ca ( 2+ ) signalling pathways . ^^^ In this report , we demonstrate that CaM KI activated by an upstream kinase ( CaM K kinase ) , but not unactivated CaM KI , phosphorylates myosin 2 regulatory light chain ( MRLC ) efficiently ( K ( cat ) , 1 . 7 s ( 1 ) ) and stoichiometrically ( approximately 0 . 8 mol of phosphate / mol ) in a Ca ( 2+ ) / CaM dependent manner in vitro . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We found that transcription of NOR 1 ( neuron derived orphan receptor 1 ) is induced by the Ca ( 2+ ) / calmodulin dependent protein kinase 4 ( CaM KIV ) cascade by differential hybridization screening of a cDNA array using probes prepared from SH SY5Y cells infected with recombinant adenoviruses expressing Ca ( 2+ ) / CaM independent mutants of CaM KIV and CaM K kinase ( CaM KK ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Mutant brains exhibited lower immunoreactivity to phospho Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) but had the same synaptic density as wild type and did not exhibit a gross neuroanatomical phenotype . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Alternative splicing modulates the frequency dependent response of CaMKII to Ca ( 2+ ) oscillations . ^^^ Remarkably , the Ca ( 2+ ) / calmodulin ( CaM ) dependent protein kinase 2 ( CaMKII ) can decode such frequencies . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| In the presence of G 6976 approximately 64 % of the carbachol induced signal transduction is mediated by Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) , and 14 % is conveyed by PKC epsilon as deduced from the inhibition with the bisindolylmaleimide Ro 31 8220 . 4 . ^^^ The TPA induced increase of H ( + ) secretion was sensitive to the cell permeable Ca ( 2+ ) chelator BAPTA / AM , Ro 31 8220 , and the CaMKII inhibitor KN 62 , but not to G 6976 . 6 . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| KN 93 , a Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) inhibitor , concentration dependently and reversibly inhibited inositol 1 , 4 , 5 trisphosphate receptor ( IP ( 3 ) R ) mediated [ Ca ( 2+ ) ] ( 1 ) signaling in mouse eggs and permeabilized A7r5 smooth muscle cells , two cell types predominantly expressing type 1 IP ( 3 ) R ( IP ( 3 ) R 1 ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| PKC in the pulmonary artery and Ca ( 2+ ) calmodulin dependent protein kinase 2 ( CaMKII ) in the femoral artery have been implicated in isoflurane induced relaxation . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The delta isoform of Ca ( 2+ ) / calmodulin activated protein kinase 2 ( CaMK 2 ) is abundantly expressed in vascular smooth muscle , but relatively little is known about its regulation or its potential cellular substrates . ^^^ Taken together these data support the idea that S 18 could be a novel substrate for CaMK 2 , thus providing a potential link between Ca ( 2+ ) mobilizing agents and protein translation . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the serotonergic modulation of AMPA currents was occluded by application of the Ca ( 2+ ) / calmodulin dependent kinase 2 ( CaMKII ) inhibitors and blocked by intracellular injection of calmodulin or recombinant CaMKII . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The enhanced learning correlates with increased phosphorylation of cyclic AMP dependent response element binding ( CREB ) protein , of Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) and of the GluR 1 subunit of the AMPA receptor ; it also correlates with CREB dependent gene expression that , in control mice , occurs only with widely distributed training . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca ( 2+ ) mediated depression of 1 ( glu ) was not found to involve CaMKII , as inhibitors of CaMKII did not prevent this depression nor did they affect the sensitivity of the response to small changes in the concentration of mGluR 6 agonist . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| A chronic ( 2 wk ) inactivation of N methyl D aspartate ( NMDA ) ionotropic glutamate receptors , L type voltage gated Ca ( 2+ ) channels , calmodulin , Ca ( 2+ ) / calmodulin dependent protein kinases II / IV ( CaMK II / IV ) , or protein kinase C ( PKC ) increased the number of cholinergic neurons ( to 15 24 % ) and induced ACh activity ( in 40 60 % of cells ) . ^^^ However , a decrease in Ca ( 2+ ) influx into cells ( through NMDA receptors or L type Ca ( 2+ ) channels ) , inactivation of intracellular Ca ( 2+ ) fluctuations , or downregulation of Ca ( 2+ ) dependent signal transduction pathways ( CaMK II / IV and PKC ) remove the tonic inhibition and trigger the development of cholinergic phenotype in some hypothalamic neurons . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Pre incubation with the phospholipase C ( PLC ) inhibitor U 73122 ( 10 microM ) , L type Ca ( 2+ ) channel blockers nifedipine ( 1 microM ) and nimodipine ( 1 microM ) , the calmodulin kinase 2 ( CaMKII ) inhibitor KN 62 ( 10 microM ) or pertussis toxin ( 100 ng / ml ) inhibited this potentiation . ^^^ In short , this study in astrocytes demonstrates that under physiological Ca ( 2+ ) and adenylate cyclase stimulation an elevation of cAMP production is achieved that is mediated by PLC / IP ( 3 ) and CaMKII dependent pathways and results in the release of endogenous adenosine which acts at G ( s ) protein coupled A ( 2A ) receptors . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Similarly , inhibition of Ca ( 2+ ) / calmodulin dependent protein kinases ( CaMK ) with KN 62 also resulted in a significant attenuation of TPA induction of the three phosphoproteins . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Interestingly , these characteristic defects resembled phenotypes observed in gain of function mutants of unc 43 / Ca ( 2+ ) calmodulin dependent protein kinase 2 ( CaMKII ) and goa 1 / G ( o ) protein alpha subunit . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Depressed SR function in these hearts was associated with a reduction in Ca ( 2+ ) / calmodulin dependent protein kinase ( CaMK ) phosphorylation of the SR Ca ( 2+ ) cycling proteins and 34 % decrease in SR CaMK activity . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Of these proteins , calmodulin ( CaM ) and Ca CaM dependent kinase 2 ( CaMKII ) are of special interest in the heart because of their role of modulating Ca influx , SR Ca release , and SR Ca uptake during E C coupling . ^^^ Indeed , CaM and CaMKII may be associated with some ion channels and Ca transporters and both can modulate acute cellular Ca handling . ^^^ In addition to the changes in Ca , CaM and CaMKII signals from beat to beat , changes may occur on a longer time scale . ^^^ Here we review the classical role of Ca in E C coupling and extend this view to the role of the Ca dependent proteins CaM and CaMKII in modulating E C coupling and their contribution to E T coupling . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We tested the hypothesis that FDAR results mainly from Ca / calmodulin dependent protein kinase 2 ( CaMKII ) dependent stimulation of sarcoplasmic reticulum ( SR ) Ca transport , but does not require phospholamban . ^^^ Isometric twitch force of muscles and unloaded shortening and Ca transients in myocytes were measured ( [ Ca ] ( o ) =1mM ) in the absence and presence of CaMKII inhibitors ( 1 microM KN 93 or 20 microM autocamtide 2 related inhibitory peptide , AIP ) . ^^^ Similarly , a different CaMKII inhibitor ( AIP ) inhibited FDAR of contraction and Ca transients in rat ventricular myocytes . ^^^ We conclude that FDAR results mainly from CaMKII dependent stimulation of SR Ca transport , but does not require phospholamban . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The function of synapsin 1 is regulated by phosphorylation of the molecule at multiple sites ; among them , the Ser ( 603 ) residue ( site 3 ) is considered to be a pivotal site targeted by Ca ( 2+ ) / calmodulin dependent kinase 2 ( CaMKII ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Selective stimulation of CaMK with Ca ( 2+ ) ionophores and of PKA with forskolin or dibutyryl cAMP both result in induction of c fos mRNA . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca ( 2+ ) influx through the N methyl d aspartate ( NMDA ) type glutamate receptor leads to activation and postsynaptic accumulation of Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) and ultimately to long term potentiation , which is thought to be the physiological correlate of learning and memory . ^^^ Like Ca ( 2+ ) / calmodulin , autophosphorylated CaMKII competes with alpha actinin 2 for binding to NR 1 . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Calmodulin is known to regulate three pathways : ( 1 ) protein phosphatase 2B ( PP2B ) , ( 2 ) Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMK 2 ) , and ( 3 ) myosin light chain kinase ( MLCK ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We have previously reported the formation of calcium / calmodulin dependent protein kinase 2 ( CaMKII ) clusters approximately 110 nm in diameter in hippocampal neurons in culture and in the intact adult brain , under conditions that simulate ischemic stress and increase [ Ca ( 2+ ) ] ( 1 ) [ Dosemeci et al . ( 2000 ) J . ^^^ We now show by pre embedding immuno electron microscopy that , indeed , CaMKII clusters are present in the CA 1 pyramidal neurons in hippocampal slices from adult rats fixed immediately after dissection , and that the number of CaMKII clusters increases with the delay time between decapitation and fixation . ^^^ Treatment of recovered slices with high potassium for 90 s causes the re appearance of CaMKII clusters in nearly all CA 1 pyramidal cells examined . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Studies on the status of multifunctional Ca ( 2+ ) calmodulin ( CaM ) dependent protein kinase 2 ( CaMKII ) in failing hearts are limited and controversial . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| A calmodulin ( CaM ) binding ' IQ ' domain on the L type Ca ( 2+ ) channel ( LTCC ) C terminus and calmodulin kinase 2 ( CaMK ) both signal increases in LTCC opening probability ( P ( o ) ) by shifting LTCCs into a gating mode ( mode 2 ) with long openings through a process called facilitation . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Whereas with 30 300 nM isoproterenol , phosphorylation of Thr ( 17 ) , the Ca ( 2+ ) calmodulin dependent protein kinase 2 ( CaMKII ) site and Ser ( 16 ) , the protein kinase A ( PKA ) site , contributed approximately 50 % each to PLB phosphorylation , and both participated in the relaxant action of isoproterenol , at lower a level of beta adrenoceptor stimulation ( isoproterenol 0 . 3 3 nM ) , both effects were exclusively due to Ser ( 16 ) phosphorylation . ^^^ The lack of Thr ( 17 ) phosphorylation at low isoproterenol concentrations might therefore be attributed to a level of PKA activity insufficient to increase [ Ca ] ( 1 ) to activate the CaMKII system and / or to inhibit the phosphatase that dephosphorylates PLB . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca ( 2+ ) / calmodulin dependent protein kinase ( CaMK ) family is responsive to changes in the intracellular Ca ( 2+ ) concentration . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The swing in ratio is approximately 5 fold and may help tune the CaMKII holoenzyme to changing intensities of Ca ( 2+ ) signaling . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| SERCA2a may be modulated through its accessory phosphoprotein phospholamban or by direct phosphorylation through Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMK 2 ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Increase of SNAP 25 expression induced by K ( + ) or DMPP was inhibited over 70 % by KN 62 and KN 93 , two Ca ( 2+ ) / calmodulin dependent protein kinase ( CaMK ) inhibitors , whereas the inactive analogue KN 92 only reduced the expression by 34 % . ^^^ The three compounds also inhibited the high K ( + ) elicited [ Ca ( 2+ ) ] ( 1 ) signal by 40 % , suggesting that the effect of KN 62 and KN 93 was a combination of CaMK / Ca ( 2+ ) influx inhibitory actions . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca ( 2+ ) / calmodulin dependent protein kinase , type 2 ( CaMK 2 ) is an enzyme encoded by four genes ( alpha , beta , gamma and delta ) and traditionally associated with synaptic function in the adult central nervous system , but also believed to play a role during neuronal development . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Exposure to acute stress reduced the amount of autophosphorylated Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) in the hippocampal CA 1 area . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| This protective effect of estradiol on Cl ( ) ATPase activity was antagonized by a pure estrogen receptor antagonist , ICI 182780 and inhibitors for cyclic GMP dependent protein kinase ( PKG ) ( KT 5823 ) , Ca ( 2+ ) calmodulin dependent protein kinase 2 ( CaMKII ) ( KN 62 ) and phosphatidylinositol ( PI ) 4 kinase ( wortmannin and quercetin ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We report here that , unlike LTP in the more mature CA 1 region of the hippocampus , LTP in neonatal rodent hippocampus ( < 9 postnatal days , < P 9 ) requires cyclic AMP dependent protein kinase A ( PKA ) but not Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| In particular , the central participation of CaMKII as a sensor of the Ca ( 2+ ) signals generated by activation of NMDA receptors after the induction of long term plastic changes , has encouraged the use of pharmacological , genetic , biochemical , and imaging tools to unveil the role of this kinase in the acquisition , consolidation , and expression of different types of memories . 3 . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| In this study , we show that Ca ( 2+ ) signaling also regulates GM CSF transcription negatively through Ca ( 2+ ) / calmodulin dependent kinase 2 ( CaMK 2 ) phosphorylation of serines in the autoinhibitory domain for DNA binding of the transcription factor Ets 1 . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The canonical Wnt / beta catenin pathway functions to stabilize beta catenin , and the noncanonical Wnt / Ca ( 2+ ) pathway activates Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The present study assesses the role of Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMK 2 ) in endothelium dependent relaxation and NO synthesis . ^^^ These results suggest that CaMK 2 was involved in NO synthesis as a result of Ca ( 2+ ) dependent activation of eNOS . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca ( 2+ ) / calmodulin regulated protein kinase 2 ( CaMKII ) mediates many cellular events . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Similarly , when the Ca ( 2+ ) / calmodulin kinase 2 ( CaMKII ) inhibitory peptide was present in the pipette , dopamine enhancement of EPSCs was not observed in any of the cells tested . ^^^ These results indicate that EPSC enhancement may be attributable to a postsynaptic signaling cascade involving Ca ( 2+ ) , PKA , and CaMKII . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The Ca ( 2+ ) / calmodulin dependent kinase CaMKII is a key signaling component in Ca ( 2+ ) dependent physiological processes . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Immunoblot analysis of the specific CaMBPs , Ca ( 2+ ) / CaM dependent kinase 2 ( CaMKII ) , calcineurin A ( CNA ) , myristoylated alanine rich C kinase substrate ( MARCKS ) and inducible nitric oxide synthase ( iNOS ) were done on lung tissue samples . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Thus , DCK 1 demonstrates the potential to be regulated by relief of autoinhibition in response to signal ( s ) distinct from Ca ( 2+ ) bound CaM and potentially by activation loop phosphorylation and to phosphorylate intracellular targets at sites similar to those recognized by CaMK pathways . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We conclude that CaMKII is the multifunctional CaMK most likely to mediate Ca ( 2+ ) dependent protein phosphorylation events in response to TAC induced cardiac hypertrophy . . ^^^ Collectively , the increased levels of CaMKII isoforms result in a constitutive increase in the Ca ( 2+ ) / calmodulin independent activity of CaMKII in the ventricles . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| In this study , we found that exposure of cortical slices to Abeta ( 1 42 ) or Abeta ( 25 35 ) induced a marked increase in the activation of protein kinase C ( PKC ) and Ca ( 2+ ) / calmodulin dependent kinase 2 ( CaMKII ) , two enzymes critically involved in a variety of cellular functions . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Direct phosphorylation of the GluR 1 subunit of postsynaptic AMPA receptors by Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaM KII ) is believed to be one of the major contributors to the enhanced strength of glutamatergic synapses in CA 1 area of hippocampus during long term potentiation . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Here , we show that protein kinase C ( PKC ) and Ca ( 2+ ) / calmodulin dependent kinase 2 ( CaMKII ) regulate the profile of human nasal CBF in response to rising temperature from 4 degrees C . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Here we show that sustained beta ( 1 ) AR stimulation promotes cardiac myocyte apoptosis by activation of Ca ( 2+ ) / calmodulin kinase 2 ( CaMKII ) , independently of PKA signaling . beta ( 1 ) AR induced apoptosis is resistant to inhibition of PKA by a specific peptide inhibitor , PKI 14 22 , or an inactive cAMP analogue , Rp 8 CPT cAMPS . ^^^ In contrast , the beta ( 1 ) AR proapoptotic effect is associated with non PKA dependent increases in intracellular Ca ( 2+ ) and CaMKII activity . ^^^ Blocking the L type Ca ( 2+ ) channel , buffering intracellular Ca ( 2+ ) , or inhibiting CaMKII activity fully protects cardiac myocytes against beta ( 1 ) AR induced apoptosis , and overexpressing a cardiac CaMKII isoform , CaMKII deltaC , markedly exaggerates the beta ( 1 ) AR apoptotic effect . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We have demonstrated previously that Ca ( 2+ ) / calmodulin dependent protein kinase IIalpha ( CaM K IIalpha ) directly phosphorylates nNOS at residue Ser ( 847 ) , and can attenuate the catalytic activity of the enzyme in neuronal cells [ Komeima , Hayashi , Naito and Watanabe ( 2000 ) J . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| During a screen for novel putative Ca ( 2+ ) / calmodulin dependent protein kinase ( CaMK ) like CREB kinases ( CLICKs ) , we have cloned a full length cDNA for CLICK III / CaMKIgamma , an isoform of the CaMKI family with an extended C terminal domain ending with CAAX motif ( where AA is aliphatic acid ) . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| It has been reported that Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) can modulate opioid tolerance via its action on learning and memory . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| These data strongly suggest that NMDA receptor channels mediated the Ca ( 2+ ) dependent activation of CaMKII and NMDA receptors surely were the substrates on membranes of active CaMKII . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Our data implicate Ca ( 2+ ) / calmodulin dependent protein kinase ( CaMK ) activity by showing that it is induced by depolarization , that CaMK activity is necessary for at least part of the survival promoting effect of depolarization , and that CaMKII or CamKIV activity suffices to support neuronal survival in the absence of other trophic stimuli . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We describe how gene ' knock out ' technology was initially exploited to disrupt the Ca ( 2+ ) / calmodulin dependent protein kinase IIalpha ( CaMKIIalpha ) gene and how refined knock in techniques later allowed an analysis of the role of distinct phosphorylation sites in CaMKII . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We report the crystal structure of the 143 residue association domain of Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We observed that this effect strongly correlated with the inhibition of Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) activity in rabbit parietal cells . ( 2 ) The aim of this study was to specify the function of PKC alpha in cholinergically stimulated H ( + ) secretion . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We measured the combined effects of CBmp and Ca ( 2+ ) CaM dependent protein kinase 2 ( CaMKII ) on L type Ca2+ channels by using an engineered Ca ( 2+ ) CaM independent form of CaMKII that remains active under low Ca ( 2+ ) CaM conditions , permissive for CBmp signalling . ^^^ CBmp and CaMKII increased L type Ca2+ channel Po in a non additive manner , suggesting that low and high Ca ( 2+ ) CaM dependent L type Ca2+ channel facilitation pathways converge upon a common signalling mechanism . . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| CaM KIdelta exhibits Ca ( 2+ ) / CaM dependent activity that is enhanced ( approximately 30 fold ) in vitro by phosphorylation of its Thr 180 by CaM K kinase ( CaM KK ) alpha , consistent with detection of CaM KIdelta activating activity in HeLa cells . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Application of KN 93 ( 10 microM ) , a specific inhibitor of CaMKII , enhanced ICl ( Ca ) in myocytes dialysed with 1 microM Ca2+ but produced no significant effect on this current when the cells were dialysed with 350 or 500 nM Ca2+ . ^^^ Moreover the balance of CaN and CaMKII regulating ICl ( Ca ) is dependent on the level of Ca2+ used to activate ICl ( Ca ) . . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We found that basal synaptic input activates the NF kappa B transcription factor by a pathway requiring the Ca ( 2+ ) / calmodulin dependent kinase CaMKII and local submembranous Ca ( 2+ ) elevation . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The present studies were designed to examine whether this cell cycle block related to alterations in protein kinase C ( PKC ) , Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CAMK 2 ) or extracellular signal regulated kinase ( ERK ) activity . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Similarly , the cardiac activity of calcium calmodulin kinase 2 ( CaMKII ) was increased significantly after IR , which confirms a regulation of Ca ( 2+ ) dependent enzymes in this model . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The effects of Ca ( 2+ ) may be mediated by Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| This study addresses the hypothesis that transient increases in Ca ( 2+ ) similar to those at fertilization stimulate oscillatory Ca ( 2+ ) / calmodulin dependent kinase 2 ( CaMKII ) enzyme activity , incrementally driving the events of egg activation . ^^^ Coanalysis of intracellular Ca ( 2+ ) levels and CaMKII activity in the same population of eggs demonstrated a rapid and transient enzyme response to each increase in Ca ( 2+ ) . ^^^ Single fertilized eggs monitored for Ca ( 2+ ) had a mean increase in CaMKII activity of 185 % . ^^^ One and two ionomycin induced Ca ( 2+ ) transients resulted in 39 and 49 % mean cortical granule ( CG ) loss , respectively , while CG exocytosis and resumption of meiosis were inhibited by a CaMKII antagonist . ^^^ These studies demonstrate that changes in the level of Ca ( 2+ ) and in CaMKII activity can be studied in the same cell and that CaMKII activity is exquisitely sensitive to experimentally induced oscillations of Ca ( 2+ ) in vivo . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| In the presence of Ca ( 2+ ) / CaM , CaMKII complexed to Cmg can autophosphorylate at T 287 and become constitutively active . ^^^ In the absence of Ca ( 2+ ) / CaM , ATP hydrolysis results in phosphorylation of T 306 and inactivation of CaMKII . ^^^ When Ca ( 2+ ) / CaM or synaptic activity is low , Cmg promotes inactivating autophosphorylation , producing CaMKII that requires phosphatase to reactivate . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) has been implicated in the regulation of neuronal excitability in many systems . ^^^ Ca ( 2+ ) / CaM is necessary to initiate binding of CaMKII to Eag but not to sustain association because binding persists when CaM is removed . ^^^ The Eag CaMKII binding domain has homology to the CaMKII autoregulatory region , and the constitutively active CaMKII mutant , T287D , binds Eag Ca ( 2+ ) independently in vitro and in vivo . ^^^ Displacement results in autophosphorylation independent activation of CaMKII which persists even when Ca ( 2+ ) levels have gone down . ^^^ Activity dependent binding to this potassium channel substrate allows CaMKII to remain locally active even when Ca ( 2+ ) levels have dropped , providing a novel mechanism by which CaMKII can regulate excitability locally over long time scales . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) plays a crucial role in the neuroplastic events underlying memory formation and other phenomena . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of nNOS at serine 847 ( Ser ( 847 ) ) by the calcium calmodulin protein kinase 2 ( CaMKII ) inhibits nNOS activity , possibly by blocking the binding of Ca ( 2+ ) CaM . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| In G ( 2 ) / M cells , both total and cell surface expressions of beta 1 integrin were comparable with those in G ( 1 ) cells but it was phosphorylated at threonines 788 789 within its cytoplasmic domain and coimmunoprecipitated Ca ( 2+ ) / calmodulin dependent protein kinase ( CaMK ) 2 . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Further , intracellular application of KN 93 , an antagonist of Ca ( 2+ ) / CaM dependent protein kinase 2 ( CaMKII ) , but not KN 92 eliminated the FFA sensitive current . ^^^ All these results suggest that Ca ( 2+ ) / CaM CaMKII pathway is involved in an activation of the FFA sensitive current . . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The `` multi functional ' ' Ca ( 2+ ) and calmodulin dependent protein kinase , type 2 ( CaMK 2 ) is an evolutionarily conserved protein . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Unexpectedly , beta ( 1 ) AR induced myocyte hypertrophy and apoptosis are independent of the classic cAMP / PKA pathway , but require activation of Ca ( 2+ ) / calmodulin dependent kinase 2 ( CaMK 2 ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| In the hippocampus , a rise of Ca ( 2+ ) activates calcium / calmodulin dependent protein kinase 2 ( CaMK 2 ) through autophosphorylation . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Phospholamban is required for CaMKII dependent recovery of Ca transients and SR Ca reuptake during acidosis in cardiac myocytes . ^^^ This recovery in rat myocytes could be inhibited by KN 93 suggesting that CaMKII dependent protein phosphorylation ( and enhanced SR Ca uptake ) may be responsible . ^^^ CaMKII inhibition using KN 93 completely prevented this recovery of Delta [ Ca ] 1 and k ( Ca ) during late acidosis in WT myocytes . ^^^ Moreover , PLB phosphorylation by CaMKII plays an important role in limiting the decline in Ca transients ( and contraction ) during acidosis . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The stimulation of glucose transport by caffeine was blocked by the Ca ( 2+ ) CAMK inhibitors KN 62 and KN 93 . ^^^ They also suggest that the stimulation of glucose transport by Ca ( 2+ ) involves activation of CAMK . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| KN 93 , a specific inhibitor of Ca ( 2+ ) / calmodulin dependent kinase 2 ( CaMKII ) , revealed no role for this kinase in peroxynitrite induced arachidonic acid release in our cell system . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| In the present study , we provide evidence that ATP dependent activation of ERK1 / 2 in VSM cells utilizes specific isoforms of the multifunctional serine / threonine kinases , PKC , and Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) as intermediates . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Many cellular responses to Ca ( 2+ ) signals are mediated by Ca ( 2+ ) / calmodulin dependent enzymes , among which is the Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) . ^^^ Putative substrates for CaMKII include proteins involved in regulating Ca ( 2+ ) storage and release , transcription factors , and ion channels . ^^^ The differential location of CaMKII isoforms and their relative activation by physiological vs . pathological stimuli may provide a paradigm for exploring and elucidating how Ca ( 2+ ) / CaMKII pathways can serve as both friends and foes in the heart . . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Previous studies demonstrated a requirement for multifunctional Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) in PDGF stimulated vascular smooth muscle ( VSM ) cell migration . ^^^ Constitutively active CaMKII delta ( 2 ) phosphorylated substrate in vitro without added Ca ( 2+ ) / calmodulin and in the intact cell without added Ca ( 2+ ) dependent stimuli , but it inhibited autophosphorylation of endogenous CaMKII delta ( 2 ) on Thr ( 287 ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Primary cultures of granule cells ( GC ) from rat cerebellar cortex were used to determine whether bioelectric activity , via a Ca ( 2+ ) / calmodulin dependent kinase ( CaMK ) signaling cascade , modulates expression and exon selection in the inositol trisphosphate receptor type 1 ( IP ( 3 ) R 1 ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Calcium / calmodulin dependent protein kinase ( CaMK ) was involved in this signaling pathway , since magnolol induced a transient rise of intracellular [ Ca ( 2+ ) ] and Ca ( 2+ ) influx across the plasma membrane , and CaMK inhibitor significantly abolished magnolol induced lipolysis . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry for Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) was performed on the rat cranial sensory ganglia . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| A series of genes that were not reported before were up regulated by phenylalanine , including Ca ( 2+ ) / calmodulin dependent protein kinase , Brain type 2 ( CaMK 2 ) , Ras , P 38 MAP kinase , L voltage dependent calcium channel , some genes related to vesicle formation and transmitter release , some glutamate receptor subunits and glutamate transporters . ^^^ According to the gene expression profile , it is likely that multi processes are involved in the neuronal injury induced by high phenylalanine , such as the activation of the NMDR Ca ( 2+ ) CaMK 2 Ras P 38 axis , the abnormality in neurotransmitter release . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| AIM : To investigate whether brain ischemia induces serine phosphorylation of neuronal nitric oxide synthase ( nNOS ) by Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) and the interaction between CaMKII . and nNOS in rat hippocampus . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Cardiac expression of Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) was analyzed by western blotting . ^^^ Direct inhibition of CaMKII activation by KN 93 ( 0 . 5 or 2 microM ) or inhibition of Ca ( 2+ ) / calmodulin dependent activation of CaMKII by W 7 ( 25 microM ) suppressed pVT in GC A / hearts ( P < 0 . 05 ) while prolonging APD . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The action of these agonists is mediated by different signalling systems ACTH is mediated by cAMP and activation of protein kinase A while Ang 2 and K ( + ) activate two protein kinases , Ca ( 2+ ) calmodulin dependent protein kinase ( CamK ) and diacylglycerol dependent protein kinase ( PKC ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| In this study , Northern blot analysis shows that the splicing of lysozyme pre mRNA in LPS activated cells is significantly delayed by treatment with KN 62 , a selective inhibitor of the Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) , but not with G 6976 and herbimycin A , inhibitors of Ca ( 2+ ) dependent PKC and PTK , respectively . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Co addition of the protein kinase C ( PKC ) inhibitor GF109203X and the Ca ( 2+ ) calmodulin dependent kinase 2 ( CaMKII ) inhibitor KN 93 blocked the ability of glutamate and carbachol to increase the association of GRK 2 with mGluR1a . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Other studies have suggested that activation of L type VSCCs leads to a Ca ( 2+ ) store dependent elevation of nuclear [ Ca ( 2+ ) ] that triggers gene expression by more direct activation of nuclear Ca ( 2+ ) / CaM dependent protein kinase ( CaMK ) . ^^^ Our simulation studies suggest that intense synaptic stimulation in combination with amplification by release from intracellular Ca ( 2+ ) stores can produce elevations in nuclear Ca ( 2+ ) concentration and CaMK phosphorylation leading to CREB phosphorylation and gene expression . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| CaMK 2 inhibition reduced both MyBP C and TnI phosphorylation and decreased active force without changing the magnitude of the [ Ca ( 2+ ) ] ( 1 ) transient . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The model also indicates that factors that promote mode 2 gating of LCCs , such as beta AR stimulation or activation of the Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) , may increase the probability of occurrence of early after depolarizations ( EADs ) , due to the random , long duration opening of LCC gating in mode 2 . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We have now found that spinophilin is phosphorylated by Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) in neurons . ^^^ In neurons , phosphorylation at Ser 100 by CaMKII was Ca ( 2+ ) dependent and was associated with an enrichment of spinophilin in the synaptic plasma membrane fraction . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| It is concluded that CaM potentiates the activity of single channel ICl ( cGMP , Ca ) by increasing the probability of channel opening via a CaMKII independent mechanism . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| To elucidate the functional link between Ca ( 2+ ) / calmodulin protein kinase 2 ( CaMKII ) and P2X receptor activation , we studied the effects of electrical stimulation , such as occurs in injurious conditions , on P2X receptor mediated ATP responses in primary sensory dorsal root ganglion neurons . ^^^ The enhancement of ATP currents depends on Ca ( 2+ ) and calmodulin and is completely blocked by the CaMKII inhibitor , 2 [ N ( 2 hydroxyethyl ) ] N ( 4 methoxybenzenesulfonyl ) ] amino N ( 4 chlorocinnamyl ) N methylbenzylamine ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The present paper reviews the evidence , which indicates that the decrease in the levels of high energy phosphates , leading to activation of AMP kinase ( AMPK ) , and the increase in cytosolic Ca ( 2+ ) , which activates Ca ( 2+ ) / calmodulin dependent protein kinase ( CAMK ) , are signals that initiate these adaptative responses . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Evidence is mounting that the calcineurin nuclear factor of activated T cells pathway and the Ca ( 2+ ) / calmodulin dependent kinases ( CaMK ) 2 and 4 play important roles in regulating oxidative enzyme expression , mitochondrial biogenesis and expression of fibre type specific myofibrillar proteins . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Earlier data indicate that Ca2+ / calmodulin dependent protein kinase ( CamK ) may mediate Ca ( 2+ ) dependent up regulation of CYP11A ( cholesterol side chain cleavage ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| A 6x His affinity precipitation assay revealed that phosphorylation by either protein kinase A ( PKA ) or Ca ( 2+ ) / calmodulin dependent kinase 2 ( CaMKII ) reduced the affinity of recombinant medaka PDs to endogenous medaka G protein beta gamma subunits ( Gbetagamma ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| A CaMKII / calcineurin switch controls the direction of Ca ( 2+ ) dependent growth cone guidance . ^^^ Here , we report that calcium calmodulin dependent protein kinase 2 ( CaMKII ) and calcineurin ( CaN ) phosphatase provide a switch like mechanism to control the direction of Ca ( 2+ ) dependent growth cone turning . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| These ATP effects were blocked ( > or=80 % inhibition ) by intracellular Ca ( 2+ ) chelation with BAPTA AM , calmodulin inhibitors , or a combination of the inhibitors of protein kinase C ( PKC ) and calmodulin dependent kinase 2 ( CaMK 2 ) . ^^^ These data indicate that ATP regulates VRAC activity via two separate Ca ( 2+ ) sensitive signaling cascades involving PKC and CaMK 2 and that cell swelling per se activates VRACs via a separate Ca ( 2+ ) / calmodulin independent signaling mechanism . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Heparin exerts an antiproliferative effect in smooth muscle cells , and the Ca ( 2+ ) / calmodulin dependent protein kinase ( CaMK ) signaling pathway is heparin sensitive . ^^^ Ionomycin increased CaMK 2 activity in both transfected and untransfected cells , with a concomitant increase in activated Ca ( 2+ ) / calmodulin . ^^^ Heparin ( 1 microg / ml ) , but not chondroitin or dermatan sulfate , significantly attenuated both serum or ionomycin induced CaMK 2 activity , and attendant c fos mRNA expression , but did not affect upstream Ca ( 2+ ) / calmodulin . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The dynamic regulation of this process is calcium dependent and involves the Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) , but astonishingly its principal regulator Calmodulin ( CaM ) could not be localized to spinules . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The increased levels of extracellular glutamate , NMDA receptor zeta subunit ( NR 1 ) mRNA , NMDA receptor epsilon 1 subunit ( NR2A ) protein , phosphorylated Ca ( 2+ ) / calmodulin kinase 2 ( p CaMKII ) protein , c fos mRNA , c Fos protein , are observed in the specific brain areas of mice and / or rats showing signs of naloxone precipitated withdrawal . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) is highly enriched in the central nervous system , and is proposed to play important roles in activity dependent modifications of neuronal functions . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Protein kinase inhibitors KN 62 , CaM dependent protein kinase ( CaMK ) 2 281 309 , autocamtide related CaMKII inhibitor peptide , and K252a ( each 1 10 microM ) did not block the effect of CaM , indicating that the effect of CaM on the Ca ( 2+ ) channel was phosphorylation independent . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| This fraction has as signalling elements a PLC dependent [ Ca ( 2+ ) ] ( 1 ) increase , resulting from Ca ( 2+ ) released from thapsigargin sensitive internal stores , followed by activation of CaM / CaMKII reactions . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Several mechanisms have been postulated to explain this effect , among which is the Ca ( 2+ ) calmodulin dependent protein kinase ( CaMKII ) dependent phosphorylation of the Thr ( 17 ) site of phospholamban ( PLN ) . ^^^ Moreover , in intact hearts , FDAR was not associated with any significant change in the CaMKII dependent phosphorylation of sarcoplasmic / endoplasmic Ca ( 2+ ) ATPase ( SERCA2a ) , and was not affected by the presence of the CaMKII inhibitor , KN 93 . ^^^ More likely , a CaMKII independent mechanism could be involved , whereby increasing stimulation frequency would disrupt the SERCA2a PLN interaction , leading to an increase in SR Ca ( 2+ ) uptake and myocardial relaxation . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We previously observed Ca ( 2+ ) dependent down regulation of Ca ( 2+ ) / calmodulin dependent protein kinase ( CaMK ) type 4 , which was attenuated by calpain inhibitors , in GCs supplemented with 20 mm KCl ( Tremper Wells , B . , Mathur , A . , Beaman Hall , C . ^^^ Depolarization and Ca ( 2+ ) dependent down regulation of CaMKIV were associated with significant alterations in other components of the Ca ( 2+ ) CaMKIV signaling cascade : the ratio of phosphorylated to total cAMP response element binding protein ( a downstream CaMKIV substrate ) was reduced by approximately 10 fold , and the amount of CaMK kinase ( an upstream activator of CaMKIV ) protein and mRNA was significantly reduced . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca ( 2+ ) / calmodulin dependent protein kinase IIalpha ( alpha CaMKII ) was once thought to be exclusively expressed in neuronal tissue , but it is becoming increasingly evident that CaMKII is also expressed in various extraneural cells . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Multifunctional Ca ( 2+ ) calmodulin dependent protein kinase ( CaMKII ) is a Ser / Thr protein kinase uniformly distributed within the sarcoplasmic reticulum ( SR ) of skeletal muscle . ^^^ Based on these findings , we propose that SR bound CaMKII participates in the regulation of glycogen metabolism , under physiological conditions involving repetitive raises elevations of [ Ca ( 2+ ) ] ( 1 ) . . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca ( 2+ ) / calmodulin dependent kinase 2 ( CaMKII ) activity in the hippocampal tissues of hypoxia induced rats was decreased to about 50 % of the control animal . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| CaMKII inhibitor KN 93 also abolished the beneficial effects of IHA hypoxia on Thr ( 17 ) phosphorylation , Ca ( 2+ ) pump ATPase activity , and the postischemic contractile recovery . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Angiotensin 2 induced Akt activation is mediated by metabolites of arachidonic acid generated by CaMKII stimulated Ca 2 ( + ) dependent phospholipase A 2 . ^^^ Angiotensin 2 ( ANG 2 ) promotes vascular smooth muscle cell ( VSMC ) growth , stimulates Ca ( 2+ ) calmodulin ( CaM ) dependent kinase 2 ( CaMKII ) , and activates cytosolic Ca ( 2+ ) dependent phospholipase A 2 ( cPLA 2 ) , which releases arachidonic acid ( AA ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Increased Ca ( 2+ ) store refilling increases the frequency of Ca ( 2+ ) release events and store refilling is enhanced by CaM kinase 2 ( CaMKII ) phosphorylation of phospholamban ( PLB ) . ^^^ These findings suggest that transient , localized Ca ( 2+ ) release events from the SR may activate CaMKII and contribute to relaxation by enhancing store refilling due to PLB Thr 17 phosphorylation . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we show that both the p 38 mitogen activated protein kinase ( MAPK ) and the Ca ( 2+ ) / calmodulin dependent kinase ( CaMKII ) are activated in response to BCR signaling to converge on Stat 1 S727 for maximal gene expression . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Phagosome maturation is dependent on macrophage Ca ( 2+ ) signaling , which results in the recruitment of cytosolic calmodulin ( CaM ) to the phagosome membrane and subsequent focal activation of CaM kinase 2 ( CaMKII ) . ^^^ This results in a failure of assembly of the Ca ( 2+ ) / CaM / CaMKII signaling complex on the membrane of the mycobacterial phagosome and the bacilli ' s persistence and replication in a protective intracellular niche . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| These effects of Wnt 5a are associated with membranous beta catenin translocation and c myc oncogene suppression and are mediated through an increase in intracellular Ca ( 2+ ) release , which via CaMKII pathways promotes beta catenin phosphorylation . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| An intracellular Ca ( 2+ ) chelator ( Quin2 / AM ) , a calmodulin inhibitor ( W 7 ) and a Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMK 2 ) inhibitor ( KN 93 ) suppressed the release of HTGL activity by heparin . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| However , neither W 7 , a calmodulin blocker , nor KN 93 , a CaMKII inhibitor , attenuated the inhibitory effect of capsaicin on 1 ( Ca ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Slow fiber type stimulation increased MEF 2 transcriptional activity , nuclear Ca ( 2+ ) concentration , and nuclear levels of activated CaMKII , but not total nuclear CaMKII or CaM YFP . ^^^ Thus , calcium transients for slow , but not fast , fiber stimulation patterns appear to provide sufficient Ca ( 2+ ) dependent activation of nuclear CaMKII to result in net nuclear efflux of HDAC 4 . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| During this period , contractility and relaxation recovered by 67+ / 9 % and 77+ / 11 % , respectively , from its maximal depression , together with an increase in the Ca ( 2+ ) calmodulin dependent protein kinase 2 ( CaMKII ) dependent phosphorylation of Thr ( 17 ) . ^^^ CONCLUSIONS : CaMKII dependent Thr ( 17 ) phosphorylation significantly increased at the beginning of acidosis , is responsible for 50 % of the early relaxation recovery , and is linked to the activation of the reverse Na ( + ) / Ca ( 2+ ) mode . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The multifunctional Ca ( 2+ ) / calmodulin ( CaM ) dependent protein kinase 2 ( CaMKII ) has emerged as a proarrhythmic and procardiomyopathic signal in a wide range of structural heart diseases . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We successfully demonstrate the effectiveness of two photon fluorescence cross correlation spectroscopy ( TPCCS ) to study the complex binding stoichiometry of calmodulin ( CaM ) and Ca ( 2+ ) / CaM dependent protein kinase 2 ( CaMKII ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Here , we examine whether induction of LTP in nociceptive dorsal horn neurons at depths of 80 500 microm from the cord surface can be affected by spinal application of the Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) inhibitor AIP . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The Ca ( 2+ ) calmodulin dependent protein kinase 2 ( CaMKII ) is a recently identified downstream element of the betaAR initiated signaling cascade that is linked to pathological myocardial remodeling and to regulation of key proteins involved in cardiac excitation contraction coupling . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We found , in total cell cytosol from the prefrontal / frontal cortex , hippocampus and striatum , a marked up regulation of Ca ( 2+ ) independent enzymatic activity and Thr ( 286 ) autophosphorylation of Ca ( 2+ ) / calmodulin dependent protein kinase ( CaMK ) 2 . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Because Ca2+ dependent protein kinases play a major role in the regulation of serotonin synthesis and release , we investigated the effect of diabetes , hyperglycemia , and acidosis on the level of indolamines [ 5 hydroxytryptamine ( 5 HT ) and / or 5 hydroxyindoleacetic acid ( 5 HIAA ) ] and Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) enzyme activity or protein expression in different brain regions . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We previously reported that in adherent vascular smooth muscle ( VSM ) cells , CaMKII mediates ERK1 / 2 activation in response to Ca ( 2+ ) mobilizing stimuli . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Induction of hippocampal long term potentiation ( LTP ) requires activation of Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) , whereas maintenance of LTP additionally requires protein synthesis . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| These signals are propagated by kinases of the Src and Syk families , which activate several adaptor molecules to trigger Ca ( 2+ ) release and , in turn , Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) activation . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Evidence is mounting that the Ca ( 2+ ) / calmodulin dependent kinases ( CaMKs ) such as CaMKII play an important role in regulating oxidative enzyme expression , mitochondrial biogenesis , and expression of fiber type specific myofibrillar proteins . ^^^ CaMKII has also been shown to remain active in a Ca ( 2+ ) independent manner after acute and prolonged exercise , and , therefore , is implicated as a mechanism for muscle memory . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| In rat hippocampus , WAY 100635 produced a rapid increase in phosphorylated Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) and in Ca ( 2+ ) independent CaMKII and protein kinase A ( PKA ) enzyme activity . ^^^ In addition , administration of WAY 100635 potentiated the learning specific increase in the hippocampus of phospho CaMKII , Ca ( 2+ ) independent CaMKII activity , as well as the phosphorylation of either the CaMKII or the PKA site on the AMPA receptor GluR 1 subunit . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca also directly activates signaling via kinases and phosphatases ( e . g . , Ca calmodulin dependent protein kinase [ CaMKII ] and calcineurin ) that occur over a longer time scale ( seconds to minutes ) , and the co localization of these Ca dependent modulators to their targets and to Ca is also critical in distinct signaling pathways . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| On the other hand , KN 62 , a selective inhibitor of rat brain Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) , diminished the increase in serine phosphorylation of GluR 6 . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| During excitation contraction coupling ( ECC ) CaMKII phosphorylates several Ca handling proteins including ryanodine receptors ( RyR ) , phospholamban , and L type Ca channels . ^^^ This was attributed to increased CaMKII dependent RyR phosphorylation , resulting in increased and prolonged openings of RyR since Ca spark frequency could be reduced back to normal levels by CaMKII inhibition . ^^^ In summary , CaMKII overexpression can lead to heart failure and CaMKII dependent RyR hyperphosphorylation seems to be a novel and important mechanism in ECC due to SR Ca leak which may be important in the pathogenesis of heart failure . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Acute administration of morphine and DAMGO stimulated ERK activity and this stimulation required activation of Ca ( 2+ ) / calmodulindependent kinase 2 ( CaMKII ) and protein kinase C ( PKC ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Neuronal Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) interacts with several prominent dendritic spine proteins , which have been termed CaMKII associated proteins . ^^^ Nonphosphorylated and Thr ( 286 ) autophosphorylated CaMKII bind to alpha actinin with similar efficacy , but autophosphorylation at Thr ( 305 / 306 ) or Ca ( 2+ ) / calmodulin binding significantly reduce this binding . ^^^ Moreover , alpha actinin antagonizes CaMKII activation by Ca ( 2+ ) / calmodulin , as assessed by autophosphorylation and phosphorylation of a peptide substrate . ^^^ CaMKII binding to densin ( 1247 1542 ) is partially independent of Thr ( 286 ) autophosphorylation and is unaffected by Ca ( 2+ ) independent autophosphorylation or Ca ( 2+ ) / calmodulin . ^^^ NR2B inhibits both the Ca ( 2+ ) / calmodulin dependent and autonomous activities of CaMKII by a mechanism that is competitive with autocamtide 2 substrate , non competitive with syntide 2 substrate , and uncompetitive with respect to ATP . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Extensive studies have shown that long term potentiation ( LTP ) of the excitatory postsynaptic current ( EPSC ) through glutamate receptors is induced by activation of N methyl D asparate receptor ( NMDA R ) the coincidence detector and Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| However , recent in vivo and in vitro studies demonstrate that another Ca ( 2+ ) / calmodulin regulated effector protein , CaMKII , is also involved . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Dephosphorylated PLN inhibits the SR Ca ( 2+ ) pump , whereas phosphorylation of PLN , at either Ser ( 16 ) by PKA or Thr ( 17 ) by calmodulin dependent protein kinase 2 ( CaMKII ) , reverses this inhibition , thus increasing SERCA2a activity and the rate of Ca ( 2+ ) uptake by the SR . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Calmodulin kinase 2 ( CaMKII ) is a major target of the Ca ( 2+ ) / CaM second messenger system . ^^^ Once bound to Ca ( 2+ ) / CaM , the multimeric CaMKII is released from its autoinhibitory status and maximally activated , which then leads to an intraholoenzyme autophosphorylation reaction . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| CDF of L type Ca2+ channels ( Ca ( 5 ) 1 . 2 ) contributes to the positive force frequency effect in the heart and is believed to involve the activation of Ca2+ / calmodulin dependent kinase 2 ( CaMKII ) . ^^^ We show that the pore forming subunit alpha ( 1C ) ( Ca ( 5 ) alpha1 . 2 ) is a CaMKII substrate and that CaMKII interaction with the COOH terminus of alpha1C is essential for CDF of L type channels . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Immunofluorescence experiments demonstrated that Ca ( 5 ) 1 . 2 calcium channels were mainly found in somata and dendrites of pyramidal neurons that exhibited immunoreactivity for calcium / calmodulin dependent protein kinase 2 ( CaMK ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Members of the Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMK 2 ) family are encoded throughout the animal kingdom by up to four genes ( alpha , beta , gamma , and delta ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We have also shown that both the C terminal domain of radixin and Galpha ( 13 ) Q226L can stimulate Ca ( 2+ ) / calmodulin dependent kinase , CaMKII . ^^^ |
|
| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The effect of lead was attenuated in the presence of a calcium ( Ca ( 2+ ) ) / calmodulin dependent protein kinase 2 ( CaMKII ) inhibitor , but not in the presence of a protein kinase C inhibitor . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The phosphorylation is catalyzed by Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) activity , as a result of activation of NR2B containing N methyl D aspartate subtype of glutamate receptors ( NMDARs ) during ischemia . ^^^ Furthermore , NR2B specific antagonist , CaMKII inhibitor , or overexpression of mutated form of ASIC1a with Ser 478 or Ser 479 replaced by alanine ( ASIC1a S478A , ASIC1a S479A ) in cultured hippocampal neurons prevented ischemia induced enhancement of ASIC currents , cytoplasmic Ca ( 2+ ) elevation , as well as neuronal death . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| We showed previously in a pituitary cell line that the Ca ( ++ ) / calmodulin dependent protein kinase CaMK 4 specifically repressed splicing of the BK channel STREX exon . ^^^ Thus , the Ca ( ++ ) / CaMK 4 pathway in neurons controls the alternative splicing of a group of exons through this short CaRRE consensus sequence . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Despite evidence from single channel RyR gating experiments that phosphorylation of RyRs by protein kinase A ( PKA ) or calcium calmodulin dependent protein kinase 2 ( CAMK 2 ) causes an increase in the sensitivity of the RyR to be triggered by [ Ca ( 2+ ) ] ( 1 ) there is little clear evidence to date showing an increase in Ca ( 2+ ) spark rate . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| With HF , expression of RyR 2 and FK 506 binding protein 12 . 6 ( FKBP12 . 6 ) were reduced , whereas inositol trisphosphate receptor ( type 2 ) and Ca / calmodulin dependent protein kinase 2 ( CaMKII ) expression were increased 50 % to 100 % . ^^^ SR Ca leak in intact HF myocytes ( which is higher than in control ) was reduced by inhibition of CaMKII but was unaltered by PKA inhibition . ^^^ CaMKII inhibition also increased SR Ca content in HF myocytes . ^^^ Our results suggest that CaMKII dependent phosphorylation of RyR 2 is involved in enhanced SR diastolic Ca leak and reduced SR Ca load in HF , and may thus contribute to arrhythmias and contractile dysfunction in HF . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| In addition , the activity of Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) in the cell controlled channel activity and alcohol modulation . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The effect of Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMK 2 ) on voltage gated ion channels is widely studied through the use of specific CaMK 2 blockers such as 2 [ N ( 2 hydroxyethyl ) ] N ( 4methoxybenzenesulfonyl ) ] amino N ( 4 chlorocinnamyl ) N methylbenzylamine ( KN 93 ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Expression of the proarrhythmic signaling protein Ca ( 2+ ) / calmodulin dependent kinase 2 ( CaMKII ) was increased while connexin 43 expression was decreased , defining an important putative mechanism in the electrophysiologic disturbances and mortality . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) and the Polo like kinase Plx 1 are essential factors for Ca ( 2+ ) induced meiotic exit , but the critical targets of these kinases were unknown . ^^^ Here , we demonstrate that CaMKII is required for Ca ( 2+ ) induced Emi 2 destruction , and that CaMKII functions as a `` priming kinase , ' ' directly phosphorylating Emi 2 at a specific motif to induce a strong interaction with the Polo Box domain of Plx 1 . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Here we show that neural activity directs the mRNA of the Drosophila Ca ( 2+ ) , Calcium / Calmodulin dependent Kinase 2 ( CaMKII ) , to postsynaptic sites , where it is rapidly translated . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Because we have previously shown that Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) participates in Erk activation in thrombin challenged cells , we next explored if CaMKII is involved in NaF induced EC responses . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Evolutionarily well conserved Ca ( 2+ ) / calmodulin dependent protein kinase ( CaMK ) proteins are known for their role as Ca ( 2+ ) signaling mediators . 1G5 encodes a CaMK like protein , which belongs to a calmodulin ( CaM ) kinase gene family . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Previous studies have suggested that Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) can modulate opioid tolerance and dependence via its action on learning and memory . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| CaMKII inactivation by extracellular Ca ( 2+ ) depletion in dorsal root ganglion neurons . ^^^ A mechanism by which Ca ( 2+ ) / CaM dependent protein kinase ( CaMKII ) is autophosphorylated by changes in extracellular calcium in the absence of detectable changes in cytoplasmic [ Ca ( 2+ ) ] has been identified . ^^^ Approximately 25 % of the measured CaMKII autophosphorylation in DRG neurons in culture can be regulated by Ca ( 2+ ) flux from intracellular stores caused by manipulating [ Ca ( 2+ ) ] ( O ) , as shown by blocking refilling of store operated Ca ( 2+ ) channels with SK & F 96365 , Ruthenium Red , and a partial block with Ni ( 2+ ) . ^^^ Blocking voltage gated Ca ( 2+ ) channels with either isradipine or SR 33805 , had no effect on CaMKII autophosphorylation induced by restoring Ca ( 2+ ) ( O ) to normal after depleting the intracellular Ca ( 2+ ) stores . ^^^ These results show that removal of Ca ( 2+ ) ( O ) has profound effects on intracellular Ca ( 2+ ) signaling and CaMKII autophosphorylation , in the absence of measurable changes in intracellular Ca ( 2+ ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Presynaptic and postsynaptic Ca ( 2+ ) and CamKII contribute to long term potentiation at synapses between individual CA 3 neurons . ^^^ Long term potentiation ( LTP ) in the Schaffer collateral pathway from the CA 3 to the CA 1 region of the hippocampus is thought to involve postsynaptic mechanisms including Ca ( 2+ ) and CamKII dependent alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid ( AMPA ) receptor insertion . ^^^ We have extended those findings by exploring the pre and postsynaptic roles of Ca ( 2+ ) and CamKII , and we have also compared results with two induction protocols , 1 Hz paired and burst paired , which may involve pre and / or postsynaptic mechanisms in addition to receptor insertion in CA 1 . ^^^ Similar to results in CA 1 , we find that CA 3 CA3 LTP completely depends on postsynaptic Ca ( 2+ ) with the 1 Hz paired protocol but depends only partially on postsynaptic Ca ( 2+ ) or CamKII with the burst paired protocol . ^^^ Potentiation with that protocol also partially depends on presynaptic Ca ( 2+ ) or CamKII , suggesting that the additional mechanisms of potentiation , at least in part , are presynaptic . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Some studies report that the positive relationship between L type Ca ( 2+ ) current ( 1 ( Ca L ) ) and frequency in cardiac myocytes is mainly due to a direct negative feedback of sarcoplasmic reticulum Ca ( 2+ ) release on 1 ( Ca L ) inactivation while others provide evidence for activation of calmodulin kinase 2 ( CaMKII ) . ^^^ We conclude that : ( 1 ) [ Ca ( 2+ ) ] ( 1 ) directly slows 1 ( Ca L ) recovery from inactivation ; and ( 2 ) Ca ( 2+ ) dependent endogenous CaMKII activity accelerates the 1 ( Ca L ) recovery . ^^^ Thus , at fast heart rates , elevated [ Ca ( 2+ ) ] ( 1 ) activates endogenous CaMKII and compensates for its direct inhibitory effect on 1 ( Ca L ) recovery from inactivation . ^^^ Dynamic activity of endogenous CaMKII enhances the positive 1 ( Ca L ) frequency relationship . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| In astrocytes , the PGF ( 2alpha ) or ionomycin treatment induces the phosphorylation at Ser 38 and Ser 82 of vimentin , a type 3 intermediate filament , by Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Pretreatment of cells with 10 microM KN 93 , a specific inhibitor of CaMKII , abolished the effects of 4 AP on 1 ( Ca . ) To test the requirement of 1 ( to ) , we studied guinea pig ventricular myocytes , which do not express 1 ( to ) channels . ^^^ In both cell types , Ca2+ induced 1 ( Ca ) facilitation , a CaMKII dependent process , was observed . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Recent studies have begun to shed light on how the egg quantitatively interprets the Ca ( 2+ ) signal ( e . g . , by summation of individual Ca ( 2+ ) rises ) and the mechanisms by which down stream Ca ( 2+ ) effectors , such as Ca ( 2+ ) / Calmodulin ( CaM ) dependent protein kinase 2 ( CaMKII ) , utilize this ionic signal to promote biological events that initiate development . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Nuclear targeting of the CaMKII anchoring protein alphaKAP is regulated by alternative splicing and protein kinases . alphaKAP is an anchoring protein for the Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) and is encoded within the same gene as the CaMKIIalpha isoform . alphaKAP co assembles with CaMKII and targets such heteromers to the membrane of the sarcoplasmic reticulum , where CaMKII can regulate Ca ( 2+ ) homeostasis . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Lack of the Ca ( 2+ ) wave propagation correlated with no coordination of the motor steps in the CaMKII mutant . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| To evaluate the role of this downregulation , we examined the relationship between Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) activation and Cdk 5 downregulation , as events downstream from NMDA stimulation . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Autophosphorylation of Ca ( 2+ ) calmodulin stimulated protein kinase 2 ( CaMKII ) at two sites ( Thr 286 and Thr305 / 306 ) is known to regulate the subcellular location and activity of this enzyme in vivo . ^^^ Using antibodies that specifically recognize CaMKII phosphorylated at Thr 253 together with FLAG tagged wild type and phospho and dephospho mimic mutants of alpha CaMKII , we have shown that Thr 253 phosphorylation has no effect on either the Ca ( 2+ ) calmodulin dependent or autonomous kinase activity of recombinant alpha CaMKII in vitro . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Intracellular application of CaMKII inhibitors KN 93 , calmidazolium , and autocamtide 2 related inhibitory peptide 2 ( ARIP 2 ) accelerated the inactivation of 1 ( to ) , even at low [ Ca ( 2+ ) ] . ^^^ On the contrary , CaMKII coimmunoprecipitated with Kv4 . 3 channels without a previous Ca ( 2+ ) increase , and the association was inhibited by KN 93 . ^^^ These results suggest that both channels underlying 1 ( to ) are substrates of CaMKII , although with different sensitivities ; Kv4 . 2 remain unphosphorylated unless [ Ca ( 2+ ) ] ( 1 ) increases , whereas Kv4 . 3 are phosphorylated at rest . ^^^ In addition to the functional impact that phosphorylation of Kv 4 channels could cause on the shape of action potential , association of CaMKII with Kv4 . 3 provides a new role of Kv4 . 3 subunits as molecular scaffolds for concentrating CaMKII in the membrane , allowing Ca ( 2+ ) dependent modulation by this enzyme of the associated Kv4 . 2 channels . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) is one of the most abundant protein kinases in the mammalian brain , especially in the hippocampus . ^^^ Neuronal CaMKII is a multifunctional mediator of activity dependent on an increase in the Ca ( 2+ ) level in excitable cells . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Despite the critical importance of Ca ( 2+ ) / calmodulin ( CaM ) dependent protein kinase ( CaMK ) 2 signaling in neuroplasticity , only a limited amount of work has so far been available regarding the presence and significance of another predominant CaMK subfamily , the CaMKI / CaMKIV family , in the central nervous system . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Modulation of cardiac Na ( + ) and Ca ( 2+ ) currents by CaM and CaMKII . ^^^ This review article summarizes how sarcolemmal Na and Ca channels are regulated with an emphasis on the novel role of Ca dependent proteins Calmodulin ( CaM ) and especially Ca / CaM dependent protein kinase 2 ( CaMKII ) to modulate sarcolemmal Na and Ca channels in the heart . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| In series 5 and 6 , cocaine effects on calcium currents ( ICa ) and intracellular Ca ( [ Ca ] 1 ) were determined before and after CaMK inhibition with KN 62 in rat myocytes . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Here we show that Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) plays a key role in this efflux . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Here we report that Ca ( 2+ ) / CaMKII is redistributed to the immune synapse following T cell activation and that CaMKII is critical for NF kappaB activation induced by TCR stimulation . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) phosphorylated the C terminal cytoplasmic region of LRP 4 at Ser 1887 and Ser 1900 , and the phosphorylation at the latter site suppressed the interaction of the protein with PSD 95 and synapse associated protein 97 ( SAP 97 ) . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Stimulation with 2MeSADP induced a Ca ( 2+ ) release from intracellular stores and a significant CaMKII phosphorylation in cell somas and neurites . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca ( 2+ ) / Camodulin dependent protein kinase 2 ( CaMKII ) is a multifunctional enzyme that is postulated to be the downstream transducer of the Ca ( 2+ ) signal in many cell types . ^^^ We tested the hypothesis that CaMKII is the major integrator of Ca ( 2+ ) induced egg activation events and embryo development by microinjecting a cRNA that encodes a constitutively active ( Ca ( 2+ ) independent ) mutant form of CaMKII ( CA CaMKII ) into mouse eggs . ^^^ Expression of this cRNA , which does not increase intracellular Ca ( 2+ ) , induced a sustained rise in CaMKII activity and triggered egg activation events , including cell cycle resumption , and degradation and recruitment of maternal mRNAs ; cortical granule exocytosis , however , did not occur normally . ^^^ Furthermore , when mouse eggs were injected with sperm devoid of Ca ( 2+ ) releasing activity and activated with either CA CaMKII cRNA or by SrCl ( 2 ) , similar rates and incidence of development to the blastocyst stage were observed . ^^^ These results strongly suggest that CaMKII is a major integrator of the Ca ( 2+ ) changes that occur following fertilization . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| The ability of CaMKII to act as a molecular switch , becoming Ca ( 2+ ) independent after activation and autophosphorylation at T 287 , is critical for experience dependent plasticity . ^^^ Phosphorylation of T 306 blocks Ca ( 2+ ) / CaM binding , lowering the probability of intersubunit T 287 phosphorylation , which requires CaM binding to both the substrate and catalytic subunits . dCASK is the first CaMKII interacting protein other than CaM found to regulate this plasticity controlling molecular switch . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) is associated with cardiac LTCC complexes and increases channel open probability ( P ( O ) ) to dynamically increase Ca ( 2+ ) current ( 1 ( Ca ) ) and augment cellular Ca ( 2+ ) signaling by a process called facilitation . ^^^ However , the critical molecular mechanisms for CaMKII localization to LTCCs and 1 ( Ca ) facilitation in cardiomyocytes have not been defined . ^^^ Moreover , expression of beta ( 2a ) ( T498A ) in adult cardiomyocytes ablates CaMKII mediated 1 ( Ca ) facilitation , demonstrating that phosphorylation of beta ( 2a ) at Thr 498 modulates native calcium channels . ^^^ These findings reveal a molecular mechanism for targeting CaMKII to LTCCs and facilitating 1 ( Ca ) that may modulate Ca ( 2+ ) entry in diverse cell types coexpressing CaMKII and the beta ( 2a ) subunit . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| Ca2+ / calmodulin dependent protein kinase phosphatase ( CaMKPase ) is a protein phosphatase which dephosphorylates autophosphorylated Ca2+ / calmodulin dependent protein kinase 2 ( CaMKII ) and deactivates the enzyme ( Ishida , A . , Kameshita , 1 . and Fujisawa , H . ( 1998 ) J . ^^^ In this study , a phosphorylation dephosphorylation relationship between CaMKII and CaMKPase was examined . ^^^ CaMKPase was not significantly phosphorylated by CaMKII under the standard phosphorylation conditions but was phosphorylated in the presence of poly L lysine , which is a potent activator of CaMKPase . ^^^ Thus , the activity of CaMKPase appears to be regulated through phosphorylation by its target enzyme , CaMKII . . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| By using extracts from transfected cells , PPM1F , but not a mutant ( R326A ) in the conserved catalytic domain , was found to dephosphorylate in vitro a peptide corresponding to the auto inhibitory region of CaMKII . ^^^ Further analyses demonstrated that PPM1F specifically dephosphorylates the phospho Thr 286 in autophosphorylated CaMKII substrate and thus deactivates the CaMKII in vitro . ^^^ Coimmunoprecipitation of CaMKII with PPM1F indicates that the two proteins can interact intracellularly . ^^^ Binding of PPM1F to CaMKII involves multiple regions and is not dependent on intact phosphatase activity . ^^^ Furthermore , overexpression of PPM1F in fibroblasts caused a reduction in the CaMKII specific phosphorylation of the known substrate vimentin ( Ser 82 ) following induction of the endogenous CaM kinase . ^^^ |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49593 and Q13555 |
Pubmed |
SVM Score :0.0 |
| NA |
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