| Interacting proteins: P49450 and Q96GD4 |
Pubmed |
SVM Score :0.0 |
| CENP A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis . ^^^ We investigated a role for Aurora B with respect to human centromere protein A ( CENP A ) , a centromeric histone H 3 homologue . ^^^ Aurora B concentrates at centromeres in early G 2 , associates with histone H 3 and centromeres at the times when histone H 3 and CENP A are phosphorylated , and phosphorylates histone H 3 and CENP A in vitro at a similar target serine residue . ^^^ Our data support a model where CENP A phosphorylation is involved in regulating Aurora B , INCENP , and PP1gamma1 targeting within the cell . ^^^ |
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| Interacting proteins: P49450 and Q96GD4 |
Pubmed |
SVM Score :0.0 |
| CENP A phosphorylation by Aurora A in prophase is required for enrichment of Aurora B at inner centromeres and for kinetochore function . ^^^ Aurora A phosphorylated CENP A in vitro on Ser 7 , a residue also known to be targeted by Aurora B . ^^^ Depletion of Aurora A or Aurora B by RNA interference revealed that CENP A is initially phosphorylated in prophase in a manner dependent on Aurora A , and that this reaction appears to be required for the subsequent Aurora B dependent phosphorylation of CENP A as well as for the restriction of Aurora B to the inner centromere in prometaphase . ^^^ |
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| Interacting proteins: P49450 and Q96GD4 |
Pubmed |
SVM Score :0.0 |
| Aurora B plays roles in spindle dynamics , chromosome condensation , and cytokinesis by interacting with many proteins such as INCENP , Survivin , CENP A , MgcRacGAP , and intermediate filaments . ^^^ |
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| Interacting proteins: P49450 and Q96GD4 |
Pubmed |
SVM Score :0.0 |
| This error rate increases with decreased size and correlates with reduced levels of CENP A and Aurora B . ^^^ |
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| Interacting proteins: P49450 and Q96GD4 |
Pubmed |
SVM Score :0.0 |
| Using quantitative chromatin immunoprecipitation and expression assays , we show that FoxM 1 is essential for transcription of the mitotic regulatory genes Cdc25B , Aurora B kinase , survivin , centromere protein A ( CENPA ) , and CENPB . ^^^ |
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| Interacting proteins: P49450 and Q96GD4 |
Pubmed |
SVM Score :0.0 |
| By profiling of gene expressions associated with downregulation of MAPK 1 induced by exogenous overexpression of DUSP 6 in pancreatic cancer cells , we found that AURKA / STK15 , the gene encoding Aurora A kinase , which plays key roles in cellular mitosis , was among the downregulated genes along with its related genes , which included AURKB , TPX 2 and CENPA . ^^^ |
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| Interacting proteins: P49450 and Q96GD4 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49450 and Q96GD4 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49450 and Q96GD4 |
Pubmed |
SVM Score :0.0 |
| NA |
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