| Interacting proteins: P49427 and Q13616 |
Pubmed |
SVM Score :0.0 |
| Association of human CUL 1 and ubiquitin conjugating enzyme CDC 34 with the F box protein p 45 ( SKP 2 ) : evidence for evolutionary conservation in the subunit composition of the CDC 34 SCF pathway . ^^^ Here we identify human CUL 1 , a member of the cullin family , and the ubiquitin conjugating enzyme CDC 34 as additional partners of p 45 ( SKP 2 ) in vivo . ^^^ |
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| Interacting proteins: P49427 and Q13616 |
Pubmed |
SVM Score :0.0 |
| Based on the requirement for CREM / ICER and Rad6B proteins in spermatogenesis , we determined expression of Cdc 34 , Rad6B , CREM / ICER isoforms , and the Skp 1 Cullin F box ubiquitin protein ligase subunits Cul 1 and Cul 2 , which are associated with Cdc 34 activity during murine testicular development . ^^^ |
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| Interacting proteins: P49427 and Q13616 |
Pubmed |
SVM Score :0.0 |
| The initial ubiquitin transfer and subsequent polymerization steps of this reaction require the coordinated action of Cdc 34 and the SCF ( HOS / beta TRCP ) ROC 1 E3 ligase complex , comprised of four subunits ( Skp 1 , cullin 1 [ CUL 1 ] , HOS / beta TRCP , and ROC 1 ) . ^^^ |
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| Interacting proteins: P49427 and Q13616 |
Pubmed |
SVM Score :0.0 |
| Furthermore , C42S / C45S and H80A mutations reduce the ability of ROC 1 to interact with CUL 1 in transfected cells and diminish the capacity of ROC 1 CUL1 to form a stable complex with Cdc 34 in vitro . ^^^ Thus , the ROC 1 RING H 2 finger may possess multiple biochemical properties that include stabilizing an interaction with CUL 1 and recruiting Cdc 34 . ^^^ |
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| Interacting proteins: P49427 and Q13616 |
Pubmed |
SVM Score :0.0 |
| Most of the genes modulated by ATB belong to several cellular signaling pathways , including Notch ( Notch homolog 2 , manic fringe homolog ) , growth factor ( FGF intracellular binding protein , PDGFalpha ) , G protein Ras MAPK ( MAPK 3 , MAP3K4 , rab3A , Rap 1 , RSG 5 , PKCtheta ) , ubiquitin proteasome ( CDC 34 , Cullin 1 , 26S proteasome ) , and apoptosis ( BAD promoter , caspase 3 ) . ^^^ |
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| Interacting proteins: P49427 and Q13616 |
Pubmed |
SVM Score :0.0 |
| Both in vivo and in vitro binding studies indicated that Cdc 34 1 200 bound to the E 3 SCF components , Cul 1 and Roc 1 , at levels comparable to the wildtype Cdc 34 . ^^^ These studies suggest that the 36 amino acid acidic tail domain of human Cdc 34 is critical for its ability to transfer ubiquitin to a substrate and is dispensable for the association of Cdc 34 with Cul 1 and Roc 1 . ^^^ We postulate that the tail domain of Cdc 34 may be important for its efficient dissociation from Cul 1 and Roc 1 , an essential requirement for ubiquitination by the budding yeast Cdc34p , or it may be required more directly for ubiquitin transfer to the substrate . . ^^^ |
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| Interacting proteins: P49427 and Q13616 |
Pubmed |
SVM Score :0.0 |
| Here , we show that the activity of human Cdc 34 in the Ub Ub ligation reaction was enhanced dramatically by SCF ' s core Ub ligase module , composed of a heterodimeric complex formed by the ROC 1 RING finger protein and the CUL 1 C terminus that contains a Nedd 8 moiety covalently conjugated at K 720 . ^^^ |
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| Interacting proteins: P49427 and Q13616 |
Pubmed |
SVM Score :0.0 |
| Following CK 2 dependent phosphorylation both UBC3B and UBC 3 bind to the F box protein beta TrCP , the substrate recognition subunit of an SCF ( Skp 1 , Cul 1 , F box ) ubiquitin ligase . ^^^ |
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| Interacting proteins: P49427 and Q13616 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49427 and Q13616 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49427 and Q13616 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49427 and Q13616 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49427 and Q13616 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49427 and Q13616 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49427 and Q13616 |
Pubmed |
SVM Score :0.0 |
| NA |
|