| Interacting proteins: P51946 and P49336 |
Pubmed |
SVM Score :0.0 |
| Here we show that cdk8 / cyclin C can regulate transcription by targeting the cdk7 / cyclin H subunits of the general transcription initiation factor IIH ( TFIIH ) . cdk 8 phosphorylates mammalian cyclin H in the vicinity of its functionally unique amino terminal and carboxy terminal alpha helical domains . ^^^ In addition , mimicking cdk 8 phosphorylation of cyclin H in vivo has a dominant negative effect on cell growth . ^^^ |
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| Interacting proteins: P51946 and P49336 |
Pubmed |
SVM Score :0.0 |
| Other proteins identified in IGCs include transcription factors , the large subunit of RNA polymerase 2 ( Pol 2 ) , and cyclin dependent kinase 8 ( cdk 8 ) . cdk 8 is the kinase partner of cyclin C and a component of the mediator complex , associated with the Pol 2 holoenzyme . cdk 8 and cyclin C can regulate transcription via phosphorylation of cyclin H and the carboxy terminal domain of Pol 2 . ^^^ |
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