| Interacting proteins: P49327 and P13688 |
Pubmed |
SVM Score :0.0 |
| Inactivation of carcinoembryonic antigen related cell adhesion molecule 1 ( CEACAM 1 ) caused insulin resistance in liver that was mostly due to increased expression of fatty acid synthase and lipid metabolism , resulting in elevated intrahepatic levels of triglyceride and long chain acyl CoAs . ^^^ |
|
| Interacting proteins: P49327 and P13688 |
Pubmed |
SVM Score :0.0 |
| CEACAM 1 ( CD66a ) mediates delay of spontaneous and Fas ligand induced apoptosis in granulocytes . ^^^ DNA fragmentation assays and annexin 5 staining revealed that binding of CEACAM 1 specific antibodies , Fab fragments and soluble CEACAM 1 Fc constructs to cell surface expressed CEACAM 1 causes a delay of spontaneous and Fas ligand ( CD95L ) induced apoptosis . ^^^ |
|
| Interacting proteins: P49327 and P13688 |
Pubmed |
SVM Score :0.0 |
| We uncover a new mechanism by which insulin acutely reduces hepatic FAS activity by inducing phosphorylation of the carcinoembryonic antigen related cell adhesion molecule 1 ( CEACAM 1 ) and its interaction with FAS . ^^^ Ceacam 1 null mice ( Cc 1 ( / ) ) show loss of insulin ' s ability to acutely decrease hepatic FAS activity . ^^^ Moreover , adenoviral delivery of wild type , but not the phosphorylation defective Ceacam 1 mutant , restores the acute effect of insulin on FAS activity in Cc 1 ( / ) primary hepatocytes . ^^^ Failure of insulin to acutely reduce hepatic FAS activity in hyperinsulinemic mice , including L SACC 1 transgenics with liver inactivation of CEACAM 1 , and Ob / Ob obese mice , suggests that the acute effect of insulin on FAS activity depends on the prior insulinemic state . ^^^ |
|