| Interacting proteins: P48357 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Tyrosyl phosphorylation of the leptin receptor and signal transducer and activater of transcription 3 ( STAT 3 ) are not affected by phosphorylation of SHP 2 . ^^^ These data suggest that activation of SHP 2 by the leptin receptor results in a decreased phosphorylation of JAK 2 and may act to attenuate leptin signal transduction . ^^^ |
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| Interacting proteins: P48357 and Q06124 |
Pubmed |
SVM Score :0.0 |
| It has been demonstrated that the SH 2 domain containing tyrosine phosphatase 2 ( SHP 2 ) negatively regulates STAT 3 mediated transcriptional activation through long form leptin receptor ( OBRb ) . ^^^ |
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| Interacting proteins: P48357 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Collectively , these results suggest that a primary function of Shp 2 in postmitotic forebrain neurons is to control energy balance and metabolism , and that this phosphatase is a critical signaling component of leptin receptor ObRb in the hypothalamus . ^^^ |
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| Interacting proteins: P48357 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Stimulation of the long form OB R did not induce tyrosine phosphorylation of a Src homology domain 2 containing protein tyrosine phosphatase , SHP 2 , while stimulation of gp 130 did . ^^^ |
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| Interacting proteins: P48357 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Herein we report that activation of ObR induces the tyrosine phosphorylation of the tyrosine phosphatase SH 2 containing phosphatase 2 ( SHP 2 ) and demonstrate that Tyr 986 within the ObR cytoplasmic domain is essential to mediate phosphorylation of SHP 2 and binding of SHP 2 to ObR . ^^^ Our findings indicate that SHP 2 is a negative regulator of STAT 3 mediated gene induction after activation of ObR and raise the possibility that blocking the interaction of SHP 2 with ObR could overcome leptin resistance by boosting leptin ' s weight reducing effects in obese individuals . . ^^^ |
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| Interacting proteins: P48357 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Transcriptional responses to leptin are increased when transmitted through ObR mutated at Tyr 986 , the SHP 2 docking domain , yet this mutation does not alter the synergy between TGF beta and leptin . ^^^ |
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