| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.63821834 |
| To investigate the functional activation of the leptin receptor , immunohistochemistry for phosphorylated signal transducer and activator of transcription 3 ( pSTAT 3 ) was examined in the arcuate nucleus and the ventromedial nucleus of the hypothalamus ( VMH ) of fasted diestrous and d 14 pregnant rats after an intracerebroventricular ( i . c . v . ) injection of either leptin ( 4 mug ) or vehicle . 0.63821834^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of 985 and 1138 tyrosine of long form leptin receptor activates SHP 2 and STAT 3 , respectively . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Leptin receptor activation downregulates many regulatory genes , including STAT 3 and PAP 1 . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Consistent with this , the STAT 3 binding site on the leptin receptor is also required for this regulation . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Leptin induced a rise in phosphorylated STAT 3 , indicating that the transferred wild type OB R was functional . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| These findings show that LEPRa / LEPRb heterodimers can not activate STAT 3 and identify sequence elements within the LEPR that are critical for the activation of JAK 2 and STAT3 . . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Over expression of PTP1B in GT 1 7 cells resulted in a dose dependent decrease in endogenous JAK 2 and STAT 3 tyrosine phosphorylation compared with cells transfected with lepR alone . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| To investigate the contribution of STAT 3 signalling to leptin action in vivo , we replaced the gene encoding the leptin receptor ( lepr ) in mice with an allele coding for a replacement of Tyr 1138 in LRb with a serine residue ( lepr ( S 1138 ) ) that specifically disrupts the LRb STAT 3 signal . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| In the same construct , we have also inserted loxP sites that flank Lepr coding exon 17 , a region that encodes a JAK docking site required for STAT 3 signaling . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Each of the three intracellular tyrosine residues in LEPR exhibited different signalling capacities : Tyr 985 was necessary and sufficient for leptin induced activation of ERK1 / 2 ; Tyr 1077 induced tyrosyl phosphorylation of STAT 5 ; and Tyr 1138 was capable of activating STAT 1 , STAT 3 and STAT 5 . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Transcript levels of the genes encoding leptin receptor ( LEPR ) , signal transducer and activator of transcription ( STAT 3 ) , BCL 2 associated 10 protein ( BAX ) , and baculoviral inhibitor of apoptosis protein repeat containing 4 ( BIRC 4 , also known as XIAP ) , were determined by reverse transcriptase quantitative polymerase chain reaction analysis of expanded and hatched blastocysts . ^^^ Depending on the dose used , leptin treatment of oocytes resulted in increased LEPR , STAT 3 , and BIRC 4 mRNA levels and reduced BAX mRNA levels in blastocysts . ^^^ In conclusion , leptin improved the ability of the oocyte to sustain embryonic development and had long term effects on blastocyst apoptosis and transcript abundance of LEPR , STAT 3 , and apoptosis associated genes . . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Leptin injection activated Stat 3 but no other STAT protein in the hypothalamus of ob / ob and wild type mice but not db / db mice , mutants that lack an isoform of the leptin receptor . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| It remains unclear how signaling is propagated downstream from the leptin receptor to STAT 3 , but this may involve novel signaling intermediates . . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of STAT 3 by leptin through leptin receptor in mouse metaphase 2 stage oocyte . ^^^ In this report , we studied the expression of leptin receptor and STAT 3 activation by leptin in metaphase 2 stage ( M 2 ) oocytes . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Leptin receptor and STAT 3 immunoreactivities in hypocretin / orexin neurones of the lateral hypothalamus . ^^^ Galanin neurones were also seen to contain leptin receptor and STAT 3 immunoreactivity . ^^^ The presence of leptin receptor and STAT 3 immunoreactivities in hypocretin / orexin containing neurones of the lateral hypothalamus suggests that leptin may directly regulate these hypothalamic neurones , most likely via an inhibitory action on hypocretin / orexin expression and / or secretion resulting in reduced food intake . . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Tyrosyl phosphorylation of the leptin receptor and signal transducer and activater of transcription 3 ( STAT 3 ) are not affected by phosphorylation of SHP 2 . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Tyr to Phe mutations in the cytoplasmic tail of the mouse leptin receptor confirmed the critical role of Tyr 1138 ( a YxxQ motif ) and STAT 3 activation for induction of leptin induced genes in PC 12 . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Direct double labeling immunofluorescence histochemistry of sections from control mice , combining a goat antiserum raised against a peptide sequence present in all leptin receptor isoforms ( Ob R ) or a guinea pig anti serum generated to a peptide sequence specific for Ob Rb with rabbit STAT 3 antiserum , demonstrated colocalization of STAT 3 and Ob R as well as colocalization of STAT 3 and Ob Rb , in many cell bodies of the arcuate nucleus . ^^^ The results suggest that circulating leptin acts via leptin receptor / STAT3 containing neurons in the ventral arcuate nucleus and that congenital leptin deficiency , as seen in obese ob / ob mice , results in a down regulation of STAT 3 mRNA and protein levels . . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| GABA neurones in the ventromedial arcuate nucleus were shown to contain leptin receptor immunoreactivity , as revealed using an antiserum generated to a sequence common to all isoforms of the leptin receptor ( Ob R ) , as well as an antiserum generated to the carboxy terminal end of the long leptin receptor ( Ob Rb ) , and immunoreactivity for the leptin induced signal transduction molecule STAT 3 . ^^^ The presence of leptin receptor and STAT 3 in GABAergic arcuate neurones , but absence of changes in gene transcription for GAD and VGAT mRNA suggests , that leptin does not transcriptionally regulate the expression of proteins involved in GABAergic transmission in arcuate neurones . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| To determine if leptin signal transduction is impaired in response to central administration of leptin and whether reduced hypothalamic leptin receptors may be contributing to the impaired signal transduction , we examined the in vivo dose response leptin induced STAT 3 activation ( phosphorylation and binding activity to the SIE M 67 oligonucleotide ) in response to i . c . v . administration of leptin along with the level of hypothalamic leptin receptor protein in young and older , late onset obese rats . ^^^ Leptin increased phosphorylation of STAT 3 transcription factor binding eight fold in the young but only four fold in the aged obese rats , and leptin receptor protein was 50 % greater in the young compared with aged rats . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| In addition , leptin receptor and STAT 3 immunoreactivities were detected in neurons of the nucleus of tractus solitarius ( NTS ) and the dorsal motor nucleus of the vagus nerve ( DMNX ) by immunofluorescence histochemistry . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| ADX increased the expression of leptin receptor mRNA , increased STAT 3 mRNA and protein levels , induced constitutive STAT 3 phosphorylation and DNA binding activity , and also reduced suppressor of cytokine signaling 3 ( SOCS 3 ) mRNA and protein levels . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Leptin receptor signal transduction involves phosphorylation of cytosolic signal transducer and activator of transcription ( STAT ) proteins , specifically phosphorylation of STAT 3 ( P STAT 3 ) . ^^^ |
|
| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Ethanol consumption also decreased hypothalamic expression of STAT 3 , a protein associated with leptin receptor activation in this region of the brain . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| While cells transfected with the signalling competent long form of the leptin receptor ( ObRb ) have been used to study leptin signalling , these are likely to be of limited use in studying STAT 3 Ser727 phosphorylation due to the importance of cell background in determining the nature of the response . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Leptin receptor and STAT 3 , a transcription factor mediating the leptin signaling , are distributed in the widespread brain regions including the cerebral neocortex , hippocampal formation and lower brainstem as well as the hypothalamus where MCH fibers and the MCH receptor are abundantly present . ^^^ These findings suggest that MCH exerts the effect through its specific receptor distributed throughout the brain and that the function of MCH is influenced by the condition of peripheral energy balance via leptin , the leptin receptor and STAT 3 , not only in the hypothalamus , but also in other brain regions . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| The long form of the leptin receptor was shown to be expressed , and leptin induced the phosphorylation of STAT 3 in the three cell types . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| It has been demonstrated that the SH 2 domain containing tyrosine phosphatase 2 ( SHP 2 ) negatively regulates STAT 3 mediated transcriptional activation through long form leptin receptor ( OBRb ) . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| In this article we show that rabbit endometrial cells express leptin receptor and that human leptin triggers phosphorylation of signal transducer and activator of transcription 3 and up regulates the expression of interleukin 1 receptor type 1 as was previously found in human endometrial cells . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Phosphorylated leptin receptor and phosphorylated signal transducer and activator of transcription 3 ( p STAT 3 ) remained elevated in association with a sustained elevation in DNA binding activity of STAT 3 in the hypothalamus throughout 16 d period of leptin infusion . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| In conclusion , the present study provides evidence of the existence of the leptin receptor , Ob Rb , and STAT 3 in the mouse taste bud cells . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Both DIO and DR animals were found to have reduced long form leptin receptor expression and enhanced basal P STAT 3 in the hypothalamus with respect to Chow . rAAV leptin caused an increase in STAT 3 phosphorylation and proopiomelanocortin expression in the hypothalamus and an increase in uncoupling protein 1 in brown adipose tissue in both Chow and DR animals , but failed to do so in DIO . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| High insulin or glucose levels in the brain could result in leptin resistance as manifested by food intake , which is probably due to the attenuation of STAT 3 phosphorylation downstream the leptin receptor . . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| After leptin , there was increased expression of tyrosine 1141 phosphorylated leptin receptor , which may contribute to STAT 3 activation . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| The recombinant feline leptin with a molecular weight of 16 kDa induced phosphorylation of the signal transducers and activators of transcription 3 ( STAT 3 ) protein in the cells expressing rat leptin receptor . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Double immunohistochemical staining confirmed that deletion of STAT 3 occurred in leptin receptor ( OB Rb isoform ) positive neurons . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| A defective nutritional regulation of leptin receptor gene expression and reduced STAT 3 signaling may be involved in the development of leptin resistance in DIO . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| GCs rapidly inhibited the leptin induced STAT 3 phosphorylation in a dose and time dependent manner , as assayed by Western blotting using anti phosphospecific STAT 3 in human hepatoma cell lines ( Huh 7 ) transiently expressing long form leptin receptor . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Not only the classical JAK 2 ( Janus kinase 2 ) STAT 3 ( signal transducer and activator of transcription 3 ) pathway , but also the phosphatidylinositol 3 kinase phosphodiesterase 3B cAMP pathway mediates hypothalamic leptin receptor signaling . ^^^ It appears that hypothalamic leptin resistance , possibly due to defective nutritional regulation of leptin receptor expression and / or reduced STAT 3 signaling in the hypothalamus , contributes to the development of obesity associated with high fat feeding and aging . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| In a second series of experiments , peripheral blood mononuclear cells ( PBMC ) were isolated from venous blood to determine the effect of stimulation with the polyclonal mitogen , concanavalin A ( ConA ) , on the long form of the leptin receptor ( Ob Rl ) mRNA abundance , and to determine whether leptin altered mitogen induced proliferation , cytokine production , or signal transducer and activator of transcription 3 ( STAT 3 ) activation . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Interestingly , human neuroblastoma CHP 100 cells also have a leptin receptor ( approximately 110 kDa , Kd = 2 . 2 + / 0 . 2 nm , Bmax = 339 + / 8 fmol . mg protein ( 1 ) ) , a progesterone receptor ( approximately 120 kDa ) , STAT 3 and Ikaros , yet their FAAH is not activated by leptin or progesterone . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Furthermore , there was a dose and time dependent increase in the phosphorylation of STAT 1 and STAT 3 , indicating that Ob R ( b ) ( the long form of the leptin receptor ) expressed by the keratinocytes is functional . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| We demonstrated the presence of leptin receptor in human immature and mature DCs both at mRNA and protein level and its capacity to transduce leptin signaling leading to STAT 3 phosphorylation . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| However , since the RIP Cre transgene is also expressed in the hypothalamus , and thereby Stat 3 was deleted from neurons expressing the leptin receptor , it was not clear as to which of the metabolic defects were due to the loss of Stat 3 from beta cells or the hypothalamus . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Our data suggested that the introduction of HCV core protein results in an increase in expression of IL 6 , gp 130 , leptin receptor , and Stat 3 . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Lifelong obliteration of STAT 3 signaling via the leptin receptor in mice ( s / s mice ) results in severe hepatic insulin resistance that is comparable to that observed in db / db mice , devoid of leptin receptor signaling . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| In GK rats , leptin induced phosphorylation of signal transducer and activator of transcription 3 was significantly reduced in the cells of the hypothalamic arcuate nucleus ( ARC ) , but not of the ventromedial hypothalamus , whereas the mRNA level of functional leptin receptor was unaltered . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that leptin binding to OB R stimulates formation of STAT 1 and STAT 3 complexes , thereby defining transcriptional motifs for genes that are under leptin control . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Stimulation of either a long form of OB R or gp 130 led to tyrosine phosphorylation of STAT 3 , whereas stimulation of the truncated form of OB R that is predominantly expressed in dbldb mice failed to do so . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| STAT 3 immunoreactivity was demonstrated in Ob R containing neurons of the paraventricular nucleus ( parvocellular part ) , periventricular nucleus , arcuate nucleus and in the lateral hypothalamic area . ^^^ The results provide an anatomical basis for a leptin action mediated by STAT 3 in Ob R containing NPY and POMC neurons of the arcuate nucleus , as well as by Ob R containing neurons of the parvocellular paraventricular nucleus and lateral hypothalamic area . . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| SHR myocytes displayed similar Ob R protein abundance and basal NO levels , a blunted leptin induced increase in NOS activity as well as enhanced basal STAT 3 levels compared with the WKY group . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| The blockade of Ob R neutralized the effects of both leptin and IL 1beta on expression of the IL 1beta system and beta 3 integrin and on phosphorylation of signal transducer and activator of transcription 3 ( Stat 3 ) . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| This antiapoptotic effect required direct cell to cell interactions , was associated with phosphorylation of signal transducer and activator of transcription 3 ( STAT 3 ) and mitogen activated protein kinase ( MAPK ) , and was reduced by blocking OB R . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Our findings indicate that SHP 2 is a negative regulator of STAT 3 mediated gene induction after activation of ObR and raise the possibility that blocking the interaction of SHP 2 with ObR could overcome leptin resistance by boosting leptin ' s weight reducing effects in obese individuals . . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| We report herein the characterization of activities of signal transduction for three types of leptin receptors ( OBRs ) from rats , the OBRa , OBRb , and OBRb with fa mutation ( OBRb fa ) , by measurement of the levels of tyrosine phosphorylation of STAT 3 ( signal transducers and activators of transcription 3 ) and MAPK ( mitogen activated protein kinase ) , which are induced by leptin stimulation of CHO cells stably expressing the OBR ( CHO OBRb , CHO OBRa , or CHO OBRb fa cells ) . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Differentiated human neuroblastoma ( SH SY5Y ) cells express endogenous ObR and IR , and respond to leptin and insulin with stimulation of STAT 3 and MAPK ( mitogen activated protein kinase ) phosphorylation , and PI3K activity . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Exposure to leptin increased the tyrosine kinase activity of ObR immunoprecipitates and resulted in activation of signal transducer and activator of transcription 3 . ^^^ |
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| Interacting proteins: P48357 and P40763 |
Pubmed |
SVM Score :0.0 |
| Leptin binding to ObR results in increased STAT 3 activation in T cells , with a different activation pattern in resting vs anti CD 3 Ab stimulated T cells . ^^^ Furthermore , ObR / STAT 3 mediated signaling in T lymphocytes is decreased in the diet induced obese mouse model of obesity and leptin resistance . ^^^ In summary , our findings show that the ObR is expressed on normal mouse lymphocyte subsets , that leptin plays a role in lymphocyte survival , and that leptin alters the ObR / STAT 3 mediated signaling in T cells . ^^^ |
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