| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| The leptin receptor activates janus kinase 2 and signals for proliferation in a factor dependent cell line . ^^^ |
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| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| In transfection studies , PTP1B dephosphorylates the leptin receptor associated kinase , Jak 2 . ^^^ |
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| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| Leptin is a JAK 2 activating cytokine via the long form leptin receptor ( Ob Rb ) . ^^^ |
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| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of Jak 2 on Ser ( 523 ) inhibits Jak 2 dependent leptin receptor signaling . ^^^ |
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| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| These findings show that LEPRa / LEPRb heterodimers can not activate STAT 3 and identify sequence elements within the LEPR that are critical for the activation of JAK 2 and STAT3 . . ^^^ |
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| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| Over expression of PTP1B in GT 1 7 cells resulted in a dose dependent decrease in endogenous JAK 2 and STAT 3 tyrosine phosphorylation compared with cells transfected with lepR alone . ^^^ |
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| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| These data suggest that activation of SHP 2 by the leptin receptor results in a decreased phosphorylation of JAK 2 and may act to attenuate leptin signal transduction . ^^^ |
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| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| Insulin inhibits leptin receptor signalling in HEK 293 cells at the level of janus kinase 2 : a potential mechanism for hyperinsulinaemia associated leptin resistance . ^^^ |
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| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| The neuroprotective effect of leptin was antagonized both in vivo and in vitro by the Jak 2 inhibitor AG 490 , indicating that it was mediated via the leptin receptor and Jak 2 activation . ^^^ |
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| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| Phosphorylated JAK 2 was primarily bound to a short 106kDa leptin receptor isoform and to a lesser extent to a 210kDa molecule . ^^^ |
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| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| Not only the classical JAK 2 ( Janus kinase 2 ) STAT 3 ( signal transducer and activator of transcription 3 ) pathway , but also the phosphatidylinositol 3 kinase phosphodiesterase 3B cAMP pathway mediates hypothalamic leptin receptor signaling . ^^^ |
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| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| Using the chemical inhibitor of Janus kinase 2 ( Jak 2 ) activity , AG 490 , and overexpression of the suppressor of cytokine signaling 3 ( SOCS 3 ) , we show that blockade of leptin receptor ( Ob Rb ) phosphorylation blocks leptin induced HSC proliferation . ^^^ |
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| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| Using pharmacological , biochemical , and cell biological approaches , we show that leptin induced platelet activation required activation of a signaling cascade that included the long form of the leptin receptor , three kinases [ Janus kinase 2 ( JAK 2 ) , phosphatidylinositol 3 kinase ( PI3K ) , and protein kinase B ( PKB / Akt ) ] , the insulin receptor substrate 1 ( IRS 1 ) , and the major human platelet cAMP phosphodiesterase phosphodiesterase 3A ( PDE3A ) . ^^^ |
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| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| ITIMs with the restricted consensus sequence occur on IL 4Ralpha , IL 3Rbeta type 2 , gp 130 cytokineR , OB R ( leptinR ) , LIF Rbeta TNF RI , G CSF R , PDGF R , Blk , Ctk / Ntk , Lsk , Zap 70 , PKB / RACalpha , PKC alpha , PKC beta , PKC gamma , PKC delta , PKC zeta , PKC epsilon , PKC eta , PKC phi , PKC mu , calmodulin dependent kinase IIdelta , SLP 76 associated protein , FYN binding protein , Shc binding protein , RasGRF 2 , CDC 25 homologue , Jak 2 , Jak 3 , PLCbeta 1 , and PLCbeta 3 . ^^^ |
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| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| Activation of the long form of OB R ( OB Rb ) results in JAK 2 phosphorylation , activation of STATs , and subsequent gene expression . ^^^ |
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| Interacting proteins: P48357 and O60674 |
Pubmed |
SVM Score :0.0 |
| JAK 2 association with the ObR and JAK 2 tyrosine phosphorylation were responsive to all three treatments . ^^^ Insulin alone down regulated the leptin signaling pathway , JAK 2 association with ObR decreased at all time points , and JAK 2 phosphorylation decreased similarly . ^^^ Leptin alone also appeared to down regulate JAK 2 association with the ObR , but stimulated the down regulated pathway to signal , JAK 2 tyrosine phosphorylation being increased at later time points . ^^^ Pretreatment with leptin followed by insulin time course showed marked up regulation of the early leptin signaling pathway , JAK 2 association with the ObR being increased by insulin while JAK 2 tyrosine phosphorylation was also increased . ^^^ |
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