| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| SOCS 3 mediates feedback inhibition of the leptin receptor via Tyr 985 . ^^^ |
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| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| A leptin dependent increase of SOCS 3 mRNA was seen in areas of hypothalamus expressing high levels of the leptin receptor long form . ^^^ |
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| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| We here show that in CHO cells stably expressing the long form of the leptin receptor ( CHO OBRl ) , leptin induces transient expression of endogenous SOCS 3 mRNA but not of CIS , SOCS 1 , or SOCS 2 mRNA . ^^^ |
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| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| Identification of the Y 985 and Y 1077 motifs as SOCS 3 recruitment sites in the murine leptin receptor . ^^^ Herein we describe how suppressor of cytokine signalling 3 ( SOCS 3 ) , a potential mediator of this leptin resistance is recruited into the activated murine leptin receptor complex . ^^^ Using a functional assay based on inhibition of leptin mediated reporter induction , and using phosphopeptide affinity chromatography we show binding of SOCS 3 to the highly conserved phosphorylated Tyr 985 and Tyr 1077 motifs within the mouse leptin receptor . . ^^^ |
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| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| In this experiment we assessed whether feeding of a high fat diet to rats affects leptin receptor ( OB R ) transcript levels or induces up regulation of the suppressors of leptin / cytokine induced signaling , SOCS 3 and PIAS 3 . ^^^ |
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| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| TaqMan analysis of gene expression following chronic FA treatment showed neither a decrease in the amount of leptin receptor ( Ob R ) mRNA , nor an increase in the negative regulators of STAT signalling , SOCS 3 ( suppressors of cytokine signalling ) or cytokine inducible sequence ( CIS ) . ^^^ |
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| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| ADX increased the expression of leptin receptor mRNA , increased STAT 3 mRNA and protein levels , induced constitutive STAT 3 phosphorylation and DNA binding activity , and also reduced suppressor of cytokine signaling 3 ( SOCS 3 ) mRNA and protein levels . ^^^ |
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| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| This study demonstrates a sustained elevation in hypothalamic leptin receptor signaling through Janus kinase STAT pathway despite an increased expression of SOCS 3 during chronic central leptin infusion . ^^^ |
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| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| We present the first evidence that suppressor of cytokine signaling 3 ( SOCS 3 ) , a protein inhibiting Janus kinase / signal transducer and activator of transcription ( STAT ) signaling distal of the leptin receptor , conveys seasonal changes in leptin sensitivity in the Siberian hamster . ^^^ |
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| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| The mechanism ( s ) responsible for the development of skeletal muscle leptin resistance is unknown ; however , a role for increased suppressor of cytokine signaling 3 ( SOCS 3 ) inhibition of the leptin receptor has been demonstrated in other rodent tissues . ^^^ |
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| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| We have previously identified suppressor of cytokine signaling 3 ( Socs 3 ) as a leptin induced negative regulator of leptin receptor signaling and potential mediator of leptin resistance . ^^^ We report here that Socs 3 ( + / ) mice display greater leptin sensitivity than wild type control mice : Socs 3 ( + / ) mice show both enhanced weight loss and increased hypothalamic leptin receptor signaling in response to exogenous leptin administration . ^^^ |
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| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| Using the chemical inhibitor of Janus kinase 2 ( Jak 2 ) activity , AG 490 , and overexpression of the suppressor of cytokine signaling 3 ( SOCS 3 ) , we show that blockade of leptin receptor ( Ob Rb ) phosphorylation blocks leptin induced HSC proliferation . ^^^ |
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| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| Feedback inhibition of leptin receptor / Jak2 signaling via Tyr 1138 of the leptin receptor and suppressor of cytokine signaling 3 . ^^^ |
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| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| Expression of leptin receptor and suppressor of cytokine signaling 3 genes in adenohypophysis of normal fed and fasted cows . ^^^ |
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| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| In 6 days of a HFD , mRNA of the postreceptor leptin inhibitor , suppressor of cytokine signaling 3 , increased 22 fold in WAT , while leptin receptor ( Lepr b ) mRNA gradually disappeared , implying leptinergic blockade at both postreceptor and receptor levels . ^^^ |
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| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| Multiplex RT PCR was performed to determine relative mRNA expression levels of the human short ( huOB Ra ) or long ( huOB Rb ) leptin receptor isoforms , or SOCS 3 . ^^^ The mitogenic effects of leptin are not a consequence of altered leptin receptor or SOCS 3 mRNA expression . . ^^^ |
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| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| We confirmed the known interactions of suppressor of cytokine signalling 3 ( SOCS 3 ) and STAT 5 with the Y 985 and Y 1077 motifs of the leptin receptor , respectively . ^^^ |
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| Interacting proteins: P48357 and O14543 |
Pubmed |
SVM Score :0.0 |
| Distinct impaired regulation of SOCS 3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women . ^^^ Animal studies have illustrated the importance of the expression in adipose tissue of the leptin receptor ( OB R ) , and of SOCS 3 an inhibitor of the leptin signaling pathway , in body weight regulation . ^^^ The aim of the present study was to investigate in human adipose tissues of the same patients the OB R isoforms and SOCS 3 expression . ^^^ Subcutaneous / visceral ratios for OB Ra the short OB R isoform , OB Rb , and SOCS 3 mRNA abundance strongly correlate with the insulin sensitivity index , HOMA % S , ( r=0 . 49 , P < 0 . 0001 , r=0 . 42 , P=0 . 0002 and r=0 . 38 , P=0 . 0002 , respectively ) in both lean and obese patients without type 2 diabetes . ^^^ |
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