| Interacting proteins: Q92851 and P48023 |
Pubmed |
SVM Score :0.0 |
| Analyses of other DISC components showed significantly higher rates of loss of expression of CASP 10 , DR 5 , FAS and FASL in SCLC compared to NSCLC . ^^^ |
|
| Interacting proteins: Q92851 and P48023 |
Pubmed |
SVM Score :0.0 |
| Autoimmune Lymphoproliferative Syndrome ( ALPS ) is generally the result of a mutation in genes associated with apoptosis , like Fas , Fas ligand , Casp 8 and Casp 10 . ^^^ |
|
| Interacting proteins: Q92851 and P48023 |
Pubmed |
SVM Score :0.0 |
| Although earlier evidence implicated caspase 10 in apoptosis signaling by CD95L and Apo2L / TRAIL , recent studies indicated that these death receptor ligands recruit caspase 8 but not caspase 10 to their death inducing signaling complex ( DISC ) even in presence of abundant caspase 10 . ^^^ In nontransfected cells expressing both caspases , CD95L and Apo2L / TRAIL recruited endogenous caspase 10 as well as caspase 8 to their DISC , where both enzymes were proteolytically processed with similar kinetics . ^^^ |
|
| Interacting proteins: Q92851 and P48023 |
Pubmed |
SVM Score :0.0 |
| The evidence that Fas L ( + ) / TRAIL ( + ) malignant plasma cells prime erythroblast apoptosis by direct cytotoxicity was also supported by the increase of FLICE in fresh immature GpA ( +dim ) erythroid cells , whereas ICE and caspase 10 increased in subsequent maturative forms . ^^^ |
|
| Interacting proteins: Q92851 and P48023 |
Pubmed |
SVM Score :0.0 |
| TRAIL , but not CD95L , induced activation of caspase 10 . bcl 2 overexpression could not prevent TRAIL induced mitochondrial dysfunction , whereas it completely prevented CD95L mediated loss of MMP and cytochrome c release . ^^^ |
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| Interacting proteins: Q92851 and P48023 |
Pubmed |
SVM Score :0.0 |
| Caspase 10 activation and IRS 1 cleavage are regulated by a MKK 1 signaling pathway but not by a phosphatidylinositol 3 kinase pathway nor by the extracellular proapoptotic ligands FasL , tumor necrosis factor alpha related apoptosis inducing ligand ( TRAIL ) , or transforming growth factor beta 3 . ^^^ |
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| Interacting proteins: Q92851 and P48023 |
Pubmed |
SVM Score :0.0 |
| RECENT FINDINGS : The genetic basis of autoimmune lymphoproliferative syndrome has continued to expand with the recently identified defects in caspase 8 and caspase 10 along with the more frequent defect in Fas and unusual Fas ligand deficiency . ^^^ |
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| Interacting proteins: Q92851 and P48023 |
Pubmed |
SVM Score :0.0 |
| Caspase 10 triggers Bid cleavage and caspase cascade activation in FasL induced apoptosis . ^^^ In contrast to caspase 8 , controversy exists as to the ability of caspase 10 to mediate apoptosis in response to FasL . ^^^ Herein , we have shown activation of caspase 10 , 3 , and 7 as well as B cell lymphoma 2 interacting domain ( Bid ) cleavage and cytochrome c release in caspase 8 deficient Jurkat ( I 9 2 ) cells treated with FasL . ^^^ In subpopulations of I 9 2 cells displaying distinct caspase 10 expression levels , cell sensitivity to FasL correlated with caspase 10 expression . ^^^ |
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| Interacting proteins: Q92851 and P48023 |
Pubmed |
SVM Score :0.0 |
| Western blotting and RT PCR were performed to detect the expression changes of Fas , FasL , caspase 10 p 20 , caspase 8 , 1 kappaB alpha , and p 1 kappaB alpha molecules in protein and mRNA levels , separately , and immunohistochemistry for molecular localization of Fas and FasL in rat hippocampus . ^^^ RESULTS : The expression of Fas , FasL , and caspase 10 p 20 in protein and mRNA levels increased after I / R , which was inhibited significantly after treatment with 20 and 40 mg 10 kg ( 1 ) of DIP ( P < 0 . 01 ) . ^^^ |
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| Interacting proteins: Q92851 and P48023 |
Pubmed |
SVM Score :0.0 |
| The majority of patients have heterozygous mutations in the FAS ( TNFRSF 6 ) gene , but the condition is genetically heterogeneous and mutations in FAS ligand and caspase 8 and caspase 10 , all of which are involved in Fas mediated signalling , have also been identified . ^^^ |
|
| Interacting proteins: Q92851 and P48023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92851 and P48023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92851 and P48023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92851 and P48023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92851 and P48023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92851 and P48023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92851 and P48023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92851 and P48023 |
Pubmed |
SVM Score :0.0 |
| NA |
|