| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.68441376 |
| Indeed , we found that treatment of Jurkat cells with 3 , 4 , 5 THS , unlike treatment with resveratrol , induced activation of caspase 8 and apoptosis by a Fas associated death domain ( FADD ) protein dependent mechanism without involving the known death ligands CD 95 ligand ( CD95L ) , tumor necrosis factor alpha ( TNFalpha ) and TNF related apoptosis inducing ligand ( TRAIL ) . 0.68441376^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Caspase 8 may be the first enzyme of the proteolytic cascade activated by the Fas ligand and tumor necrosis factor ( TNF ) . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Interaction of the adenovirus 14 . 7 kDa protein with FLICE inhibits Fas ligand induced apoptosis . ^^^ Cell death induced by the overexpression of Fas ligand , Fas associated death domain containing protein ( FADD ) / MORT1 , or FADD like interleukin 1beta converting enzyme ( FLICE ) / caspase 8 in a virus free system was efficiently blocked by 14 . 7K expression . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Expression of RICK promoted the activation of caspase 8 and potentiated apoptosis induced by Fas ligand , FADD , CLARP , and caspase 8 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The binding of Fas ligand to Fas recruits caspase 8 to Fas via an adaptor , FADD / MORT1 , and activates a caspase cascade leading to apoptosis . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| This contrasts with the anti apoptotic influence of Bcl 2 family proteins in the cell death pathway induced by Fas ligand or tumor necrosis factor ( TNF ) , in which Bcl 2 typically acts downstream of Fas / TNFR1 mediated activation of caspase 8 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Taken as a whole , our data demonstrate that : ( a ) AFP induces apoptosis in tumor cells independently of Fas / Fas ligand or TNFR / TNF signaling pathways , and ( b ) AFP mediated cell death involves activation of the effector caspase 3 like proteases , but is independent of upstream activation of the initiator caspase 1 , caspase 8 , and caspase 9 like proteases . . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| However , MCF 7ADR cells possess a deletion mutation in p 53 and have considerably reduced levels of the Fas receptor , Fas ligand , caspase 2 , caspase 6 , and caspase 8 , suggesting that paclitaxel resistance may also stem from a bona fide block in paclitaxel induced apoptosis in these cells . ^^^ Morever , it appears that changes in the levels / activity of p 53 , the Fas receptor , Fas ligand , caspase 2 , caspase 6 , or caspase 8 activity have little effect on paclitaxel induced cytotoxicity and apoptosis in human breast cancer cells . . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The activation of TNF Receptor 1 or Fas Ligand Receptor lead to activate of caspase 8 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| It was found that activated T cells rapidly acquire the expression of both Fas and Fas ligand ( FasL ) on their surface and contain high levels of the precursor form of the pro apoptotic enzyme , caspase 8 ( FLICE ) . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Fas ligand binding on oocytic fas may result in caspase 8 activation . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| To detect the expression of apoptosis related molecules , ribonuclease protection assay was used with specific antisense RNA probes for Fas , Fas ligand , TNFR 1 , TRAIL , FADD , TRADD , RIP , FAF , FAP , and caspase 8 . ^^^ Immunostaining for Fas , Fas ligand , TRAIL , TRADD , RIP , and caspase 8 was also performed . ^^^ Compared with control and contralateral kidneys , the ligated kidneys displayed a dynamic expression of mRNAs for many apoptosis related molecules , which included an up to threefold increase for Fas , Fas ligand , TNF R 1 , TRAIL , TRADD , RIP , and caspase 8 , and an up to twofold increase for FADD and FAP , but there was little change for FAF . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Induction of apoptosis in MGMT cells was not triggered by Fas and Fas ligand ( CD 95 , Apo 1 ) because both proteins remained unaltered in expression and receptor proximal caspase 8 was not activated after methylation . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| This tumor induced T cell death is mediated by the activities of caspase 8 and caspase 3 and is partially inhibited by antibodies to either Fas or Fas ligand . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Western blotting showed that treatment of cells with RGD tachyplesin could activate caspase 9 , caspase 8 , and caspase 3 and increase the expression of the Fas ligand , Fas associated death domain , caspase 7 , and caspase 6 , suggesting that apoptotic molecules related to both mitochondrial and Fas dependent pathways are involved in the induction of apoptosis . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Fas associated death domain protein ( FADD ) and caspase 8 mediate up regulation of c Fos by Fas ligand and tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) via a FLICE inhibitory protein ( FLIP ) regulated pathway . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| One set studied the expression of Fas , Fas ligand , caspase 8 , Fas associated death domain , and tumor necrosis factor receptor associated death domain genes and the second set studied the expression of caspase 2 , 4 , 6 , 7 , and 10 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Here we show that NF kappaB activation upregulates the caspase 8 inhibitor FLIP , resulting in increased resistance to Fas ligand ( FasL ) or TNF . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Co transduction of p27Kip1 strongly augments Fas ligand and caspase 8 mediated apoptosis in U 373MG glioma cells . ^^^ MATERIALS AND METHODS : In this study , we transduced U 373MG glioma cells with the Fas ligand or caspase 8 genes using adenovirus vectors after transduction of the p27Kip1 gene to induce cell cycle arrest in U 373MG cells , and evaluated the degree of apoptosis . ^^^ RESULTS : The results demonstrate that expression of p27Kip1 enhanced Fas ligand or caspase 8 mediated apoptosis in U 373MG cells . ^^^ Expression of apoptosis related genes such as Bax , Bcl 10 ( L ) , Bcl 2 or caspase 8 were reduced by p27Kip1 transduction compared with that of beta actin , whereas p27Kip1 transduction did not affect the expression level of Fas or the Fas ligand . ^^^ CONCLUSION : Combined transduction of p27Kip1 with Fas ligand or caspase 8 would overide the resistance mechanism to apoptosis in malignant gliomas . . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| However , other proteins analyzed [ namely , Apaf 1 , Bax , Bid , caspase 3 , caspase 8 , caspase 9 , 10 linked inhibitor of apoptosis protein ( XIAP ) , cellular inhibitor of apoptosis protein ( cIAP ) 1 , cIAP 2 , cytochrome c , Fas , Fas ligand , FLIP , p 53 , and poly ( ADP ribose ) polymerase ] were not affected by either rituximab or cisplatin . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Examination of CDDO effects on expression of several apoptosis relevant genes demonstrated significant reductions in the levels of caspase 8 homolog Fas ligand interleukin 1 converting enzyme ( FLICE ) inhibitory protein ( c FLIP ) , an endogenous antagonist of caspase 8 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Activation of caspase 8 induced either by TNF or by Fas ligand expression was prevented by the R 1 protein . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Interferon gamma ( IFNgamma ) acts on human erythroid colony forming cells ( ECFCs ) to up regulate Fas , without a demonstrable change of Fas ligand ( FasL ) or Fas associated DD containing protein ( FADD ) expression and activates caspase 8 plus caspase 3 , which produce apoptosis . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| On the other hand , treating HUVECs with Ox LDL did not lead to any significant change in the expression of death mediators , including Fas , Fas ligand ( FasL ) , FADD , and FLICE as assessed by multiplex polymerase chain reaction amplification . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| However , it was unknown whether imexon activates an intrinsic apoptotic pathway that is associated with activation of caspase 9 or an extrinsic pathway that is induced by receptor mediated signals such as Fas ligand characterized by caspase 8 activation . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The mycotoxin penicillic acid inhibits Fas ligand induced apoptosis by blocking self processing of caspase 8 in death inducing signaling complex . ^^^ Upon engagement with Fas ligand ( FasL ) , Fas rapidly induces recruitment and self processing of caspase 8 via the adaptor protein Fas associated death domain ( FADD ) , and activated caspase 8 cleaves downstream substrates such as caspase 3 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Apoptosis induced by ( E ) 5 ( 2 bromovinyl ) 2 ' deoxyuridine in varicella zoster virus thymidine kinase expressing cells is driven by activation of c Jun / activator protein 1 and Fas ligand / caspase 8 . ^^^ The findings also show that the drug causes the induction of c Jun and the activation of activator protein 1 resulting in increased level of Fas ligand ( FasL ) and caspase 8 / 3 activation . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Fas ligand in pemphigus sera induces keratinocyte apoptosis through the activation of caspase 8 . ^^^ Pemphigus sera induced cell death is partially inhibited by pretreatment with anti Fas ligand antibodies and by incubation with caspase 8 inhibitor Z IETD FMK . ^^^ Finally , caspase 8 is activated in keratinocytes provided with sera from pemphigus patients , whereas cleavage is partially blocked by pretreatment of sera with anti Fas ligand antibody . ^^^ These results suggest that increased Fas ligand in pemphigus sera is responsible for keratinocyte apoptosis , which occurs through the activation of a caspase 8 driven extrinsic apoptotic pathway . . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| IL 12 decreased the number of Fas ligand positive CD 8 T cells and inhibited the activation of caspase 8 and caspase 3 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Although concentrations of Bcl 2 , Bax , FLICE inhibitory protein ( FLIP ) , and Fas ligand were unaffected by MG 132 or actinomycin D , both treatments led to a significant increase of p 53 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| This review focuses on novel strategies to induce apoptosis in glioma cells by transduction with adenoviral vectors carrying a variety of apoptosis related genes , including Fas ligand , Fas , FADD , caspase 8 , p 53 , p33ING1 , p73alpha , Bax , Apaf 1 , caspase 9 , IkappaBdN , caspase 3 , Bcl 2 , and Bcl 10 ( L ) . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| After a 48 h incubation with Fas ligand , mean 28 . 5 % of brain motoneurons and 29 . 4 % of spinal motoneurons underwent apoptosis , with an inhibition by Z IETD FMK , a caspase 8 inhibitor . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Protection of hepatocytes by caspase 8 siRNA significantly attenuated acute liver damage induced by agonistic Fas ( CD 95 ) antibody ( Jo 2 ) or by adenovirus expressing Fas ligand ( AdFasL ) . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Although caspase 8 is known to be involved in death receptor dependent apoptosis , measurable caspase 8 activity or even RGC death could be induced by neither tumor necrosis factor alpha nor Fas ligand injections into unlesioned eyes . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Caspase 8 , one of the initiator caspases , plays an important role in the Fas Fas ligand pathway . ^^^ In this study , we evaluated the sensitivity of a series of human neuroblastoma cell lines to membrane bound Fas ligand induced cell death , as well as the expression of Fas , caspase 3 and caspase 8 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| METHODS : Myocardial biopsies from 17 patients at the time of LVAD implantation and after explantation , at the time of heart transplantation ( HTx ) , were examined by terminal deoxynucleotidyltransferase mediated dUTP nick end labeling ( TUNEL ) reaction and with antibodies against Fas ligand ( FasL ) , Fas , tumor necrosis factor ( TNF ) alpha receptor 1 ( TNF R 1 ) , TNF alpha receptor 2 ( TNF R 2 ) , TNF alpha , TNF alpha converting enzyme ( TACE ) , poly ( ADP ribose ) polymerase ( PARP ) , poly ( ADP ribose ) ( PAR ) , caspase 3 and FLICE inhibitory protein ( FLIP ) . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Activation of Fas receptor by Fas ligand causes caspase 8 activation and apoptosis in cells and is an important mechanism by which normal tissue homeostasis and function are maintained . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| This ability to activate caspase 8 depends on their overexpression of TNF alpha and Fas ligand induced by CCL 16 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Interestingly , expression of dominant negative FADD and treatment with caspase 8 inhibitor efficiently prevented TGF beta 1 induced apoptosis , whereas the treatment with an activating CH 11 or a neutralizing ZB 4 anti Fas antibody , recombinant Fas ligand , or Fas Fc chimera did not affect activation of Fas and the subsequent induction of apoptosis by TGF beta 1 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Further analysis demonstrated that inhibition of Fas ligand , tumor necrosis factor alpha , or TRAIL signaling with blocking reagents did not affect fenretinide induced apoptosis , raising the possibility that fenretinide activates caspase 8 in a death receptor independent manner . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Induction of apoptosis was preceded by increased expression of Fas ligand ( FasL ) mRNA , resulting in expression of membrane bound FasL , which was followed by sequential activation of caspase 8 and 3 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Ethanol binge increased caspase 3 and caspase 8 activity , the expression of Fas ligand , and terminal deoxynucleotidyl transferase mediated deoxyuridine triphosphate nick end labeling in fa / fa rats . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Cytotoxic cytokines such as tumor necrosis factor ( TNF ) alpha or Fas ligand ( FasL ) bind to their receptors to activate caspase 8 , while damaging agents can cause mitochondrial release of cytochrome c , which can initiate activation of caspase 9 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Zeta associated protein of 70 kDa ( ZAP 70 ) , but not Syk , tyrosine kinase can mediate apoptosis of T cells through the Fas / Fas ligand , caspase 8 and caspase 3 pathways . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Caspase 8 and 3 activity , and concentrations of TNF alpha , Fas , Fas ligand , cytochrome c , and adenosine triphosphate ( ATP ) were measured in the neocortex by enzymatic assay and Western blot analysis . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| In the present study , to show the abnormality of Fas ligand ( FasL ) / Fas mediated apoptosis signal transducing factors in the aaLBs of the SAMP ovaries , we assessed the changes in the expression of FasL , Fas , caspase 8 and caspase 3 mRNAs by reverse transcription polymerase chain reaction , and in the expression and localization of FasL , Fas and activated caspase 3 proteins by Western blotting and immunohistochemistry , respectively , during the estrus cycle / luteolysis . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| We observed increased levels of several Fas mediated apoptosis effectors ( Fas , Fas ligand , FADD , FLICE ) , both in cell cultures at advanced passages and in skin cells of aged donors ( above 45 years ) . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical analysis revealed that zinc inhibited ethanol induced endogenous Fas ligand activation , which is a key component in signaling pathways leading to hepatic caspase 8 and subsequent caspase 3 activation and apoptosis . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Autoimmune Lymphoproliferative Syndrome ( ALPS ) is generally the result of a mutation in genes associated with apoptosis , like Fas , Fas ligand , Casp 8 and Casp 10 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| However , no significant treatment associated changes were observed in Bid , Fas , Fas ligand , p 53 , and caspase 8 and 10 proteins in either placenta or uterus . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| In Fas ligand treated cells , ECH is only able to inhibit the activation of pro caspase 8 and it has no effect on the already activated caspase 8 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Furthermore , treatment with 20 microM gamma tocotrienol had no effect on total , membrane , or cytosolic levels of Fas , Fas ligand ( FasL ) , or Fas associated via death domain ( FADD ) and did not induce translocation of Fas , FasL , or FADD from the cytosolic to the membrane fraction , providing additional evidence that tocotrienol induced caspase 8 activation is not associated with death receptor apoptotic signaling . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Caseamembrin C also induced the up regulation of Fas ligand ( FasL ) expression , cleavage and activation of caspase 8 and caspase 9 , Bid cleavage and activation of executor caspase 3 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| METHODS : Grade 1 ( non OA ) femoral condyles and tibial plateaus from mature and aged rabbits were taken for assessment of viable cell density ( VCD ) and mRNA ( reverse transcription polymerase chain reaction ) expression levels of the pro apoptotic genes , Fas , Fas ligand ( FasL ) , caspase 8 , inducible nitric oxide synthase ( iNOS ) and p 53 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The kidneys were harvested 1 , 3 , or 7 days postoperatively , and tissue samples were subsequently analyzed for TNF alpha ( ELISA , RT PCR ) , Fas ligand ( RT PCR ) , apoptosis ( TUNEL , ELISA ) , and caspase 8 and 3 activity ( Western blot ) . ^^^ Renal obstruction induced increased tissue TNF alpha and Fas ligand mRNA levels , TNF alpha protein production , apoptotic renal tubular cell death , and elevated caspase 8 and 3 activity , whereas treatment with PEG sTNFR 1 significantly reduced obstruction induced TNF alpha production , renal tubular cell apoptosis , and caspase activity . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| We showed that expression of Fas and Fas ligand was upregulated and caspase 8 was significantly activated in CoCl ( 2 ) induced apoptotic cells . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| We also examined several factors that may affect apoptosis , including p 53 , p21 / WAF1 , Fas receptor , Fas ligand ( FasL ) and caspase 8 activity . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation was performed to assess for FAS receptor / FAS ligand complex formation , and activation of caspase 8 and BID ( a member of the Bcl 2 family of proteins ) was assessed by Western blot analysis . ^^^ Retinal detachment resulted in the transcriptional upregulation of the FAS receptor , FAS ligand , caspase 8 and BID , but not caspase 9 and cytochrome c . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| In the first trimester , the receptor mediated pathway prevails over the mitochondrial pathway with a moderate / intense expression of its three components , viz . , Fas ligand ( FasL ) , Fas , and caspase 8 , and weak positivity of anti apoptotic FLIP , these proteins being mainly localized in the cytotrophoblast compartment . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| RECENT FINDINGS : The genetic basis of autoimmune lymphoproliferative syndrome has continued to expand with the recently identified defects in caspase 8 and caspase 10 along with the more frequent defect in Fas and unusual Fas ligand deficiency . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| In contrast , the activation of initiator caspase 8 and cleavage of Bid were not affected after Fas ligand stimulation . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Administration of the dual APL to mice concomitant with the immunization with either of the myasthenogenic peptides resulted also in the up regulation of c Jun NH 2 terminal kinase activity and of Fas signaling pathway molecules as determined by measuring Fas , Fas ligand , and caspase 8 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| There are two pathways of caspase 3 and caspase 7 mediated apoptosis : ( 1 ) the `` extrinsic ' ' pathway involving the death receptor Fas , Fas ligand ( FasL ) , and caspase 8 and ( 2 ) the `` mitochondrial ' ' or `` intrinsic ' ' pathway involving Bcl 2 proteins , caspase 2 , cytochrome c release , and caspase 9 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Although ZVAD sensitive caspase 8 processing occurred in both cell types , pretreatment with either fas receptor blocking ZB 4 or fas ligand NOK 1 neutralizing antibodies did not inhibit HQ induced apoptosis . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Activations of caspase 8 and 3 were detected from dying HAoSMCs . 7 Ketocholesterol inhibited translocation of the nuclear factor kappaB ( NF kappaB ) subunits of p 65 and p 50 from the cytosol into the nucleus , increase of NF kappaB activity , and expression of caspase 8 homolog Fas ligand interleukin 1 converting enzyme inhibitory protein by TNF alpha . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Meanwhile , immunoblotting analysis also showed that the co administration of esculetin and Taxol could increase the expression of Bax and the cytosolic release of cytochrome C and enhance the expression of Fas and Fas ligand while the activation of caspase 8 and caspase 3 was also increased . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The aortic level of 8 ( OH ) dG and the expression of caspase 8 , caspase 9 and Fas ligand were also suppressed after ellagic acid supplement . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Inhibition of Fas ligand and TNF related apoptosis inducing ligand induced apoptosis by muristerone A occurs at the level of caspase 8 activation and is neutralized by phosphatidylinositol 3 kinase / Akt , protein kinase C and mitogen activated protein kinase inhibitors . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Similarly , immunoreactivity for the apoptotic signals Fas , Fas ligand , Bax , Bcl 10 , caspase 8 , caspase 9 and caspase 3 was absent from the NBM of AD and control brains . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Activation of several cell death programs represented by Fas ligand , FADD ( Fas Associated Death Domain / Mort1 ) and the caspase cascade ( caspase 8 and 3 ) and survival programs represented by phosphorylated protein kinase B ( PKB / Akt ) , Bcl 2 associated death domain ( BAD ) , and cAMP responsive element binding protein ( CREB ) were examined using immunohistochemistry and Western blotting . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| ANG 2 induced apoptosis was characterized by marked inhibition of Akt phosphorylation and stimulation of membrane Fas ligand ( FasL ) expression , caspase 8 activation , and a reduction in soluble FasL expression . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| RNA was extracted from the articular cartilage and menisci of the affected knee and was examined with regard to expression of the following genes : Caspase 8 , Fas , Fas ligand ( Fas L ) , p 53 , aggrecanase , matrix metalloproteinase ( MMP ) 1 , and MMP 3 MMP 13 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| While both drugs reduced the expression of Fas ligand ( FasL ) and caspase 8 , treatment with hCDR 1 resulted in reduced whereas dexamethasone administration resulted in increased rate of apoptosis . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The majority of patients have heterozygous mutations in the FAS ( TNFRSF 6 ) gene , but the condition is genetically heterogeneous and mutations in FAS ligand and caspase 8 and caspase 10 , all of which are involved in Fas mediated signalling , have also been identified . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Moreover , the expressions of Fas ligand , caspase 8 , and caspase 9 in the aortic arches were also markedly lowered after M . officinalis and lovastatin supplements . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| However , the activity of caspase 8 and the expression level of Fas ligand mRNA were comparable with those of the untreated rats . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Crm A , bcl 2 and NDGA inhibit CD95L induced apoptosis of malignant glioma cells at the level of caspase 8 processing . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Inhibition of caspase 3 , a downstream protease in the CD 95 signaling pathway , blocked both CD95L and UVB induced apoptosis , whereas blockage of caspase 8 , the most proximal caspase , inhibited CD95L mediated apoptosis completely , but UVB induced apoptosis only partially . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Moreover , despite the specific caspase 8 inhibitor z IETD fmk substantially protecting transformed CL 01 B cells from CD95L fp mediated apoptosis and permitting their ongoing proliferation , caspase 8 inhibition had no protective effects on CD95L fp mediated inhibition of constitutive IgM production by CL 01 B cells . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Costimulation with the GC receptor antagonist mifepristone diminished monocyte apoptosis as well as CD95 / CD95L expression and subsequent caspase 8 and caspase 3 activation . ^^^ In contrast , the caspase inhibitor N : acetyl Asp Glu Val Asp aldehyde suppressed caspase 3 activation and apoptosis , but did not down regulate caspase 8 activation and expression of CD 95 and CD95L . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Ectopic expression of the preferential caspase 8 inhibitor , crm A , inhibits Ad CD95L induced cell death but has no effect on TK / GCV cytotoxicity . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Although earlier evidence implicated caspase 10 in apoptosis signaling by CD95L and Apo2L / TRAIL , recent studies indicated that these death receptor ligands recruit caspase 8 but not caspase 10 to their death inducing signaling complex ( DISC ) even in presence of abundant caspase 10 . ^^^ In nontransfected cells expressing both caspases , CD95L and Apo2L / TRAIL recruited endogenous caspase 10 as well as caspase 8 to their DISC , where both enzymes were proteolytically processed with similar kinetics . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| CD95L induced cell death augmented by AG 1478 is accompanied by enhanced processing of caspase 8 . ^^^ LN 229 cells overexpressing the viral caspase inhibitor , crm A , are not sensitized to CD95L induced cell death by AG 1478 , indicating that EGFR exerts its antiapoptotic properties through a caspase 8 dependent pathway . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Similar to CD 95 ligand ( CD95L ) , TRAIL signaling requires ligand receptor interaction ; the downstream signaling molecules , such as Fas associated death domain and caspase 8 , also seem similar . ^^^ The decrease in MMP induced by both ligands was caspase 8 mediated ; no difference in caspase 8 activation by TRAIL and CD95L was found . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| We investigated the mRNA expression of the apoptosis mediators cellular FLICE inhibitory protein ( cFLIP ) , caspase 8 , CD 95 and CD95L in peripheral blood mononuclear cells ( PB MNCs ) from MS patients using real time PCR . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| In HL 60 and RL , cell cycle analysis showed , at a distinct SubG 1 region , that CD 95 and CD 95 ligand ( CD95L ) expression was upregulated , caspase 8 and caspase 3 were activated , and Bcl 2 protein expression was downregulated . ^^^ On the other hand , in K 562 , the cell cycle was arrested at the G2+M phase , CD95 / CD95L expression was upregulated , caspase 8 and caspase 3 were activated , but Bcl 2 expression was not changed as compared with untreated cells . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Activation of caspase 8 , Bid cleavage , cytochrome c release and caspase 3 activation followed after CD95L induction indicating a functional CD 95 signaling cascade . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| CD 95 mutants with tyrosine phenylalanine exchanges at positions 232 and 291 failed to translocate to the plasma membrane and to recruit Fas associated death domain and caspase 8 , although these mutants still associated with the EGFR in the cytosol in response to hyperosmolarity and CD95L . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| This went along with an increase of CD 95 and CD95L surface expression , shedding of CD95L into the supernatant , cleavage of caspase 3 and caspase 8 , and elevated JNK 2 , c Jun , and CD95L mRNA expression . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Our observations suggest a Fas / FasL independent mechanism for drug induced apoptosis and exclude the involvement of caspase 1 and caspase 8 in this process in T acute lymphatic leukemia cells . . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| More than half of the HSVtk / GCV induced cell death could be abrogated by addition to the cell culture medium of a specific antisense oligonucleotide to block FasL synthesis , a recombinant Fas / Fc chimeric protein to compete with Fas receptor for FasL binding , or cell permeable specific tetrapeptide inhibitors of caspase 3 or caspase 8 . . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Consistently , in Jurkat T cells , expression of PKCtheta AE / CaN significantly enhanced FasL protein expression and apoptosis in a CD 95 dependent manner since cell death was not observed in T cells co expressing the caspase 8 inhibitor crmA . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Our aims were to determine if altered expression of FasR and FasL or changes in expression of FLICE inhibitor ( 1 FLICE ) allow cholangiocarcinoma cells to escape immune surveillance . ^^^ Human cholangiocarcinoma cell lines were evaluated for the functional expression of FasR and FasL by ( 1 ) quantitating apoptosis after incubation of cells with agonistic antibodies and ( 2 ) an in vitro cell death assay involving coculture of cholangiocarcinoma cells with Fas sensitive thymocytes . 1 FLICE antisense treatment was performed by stable transfection with complementary DNA ( cDNA ) for 1 FLICE in the reverse orientation . ^^^ Human cholangiocarcinoma cell lines express both FasL and FasR and 1 FLICE . ^^^ We concluded that cholangiocarcinomas escape immune surveillance either by disabling FasR signaling through the expression of 1 FLICE and / or increased FasL expression to induce apoptosis of invading T cells . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Most ( 75 % ) of these were saved by Fas Fc receptor body , which blocks interactions between Fas and FasL , or by the caspase 8 inhibitor tetrapeptide IETD . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Interestingly , caspase 8 activation was observed upon drug exposure , independently from Fas / FasL signaling . . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Activation of Fas ( CD 95 ) by its ligand ( FasL ) rapidly induces cell death through recruitment and activation of caspase 8 via the adaptor protein Fas associated death domain protein ( FADD ) . ^^^ RESULTS : Under conditions in which proliferation of CD 3 activated human T lymphocytes is increased by recombinant FasL , there was activation of the transcription factors NF kappaB and AP 1 and recruitment of the caspase 8 inhibitor and FADD interacting protein FLIP ( FLICE like inhibitory protein ) . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| However , unlike FADD / and caspase 8 / cells , casper / embryonic fibroblasts are highly sensitive to FasL or TNF induced apoptosis and show rapid induction of caspase activities . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Activation of caspase 8 in response to Fas triggering by recruitment of caspase 8 to the Fas has also been found , however , MMC did not induce FasL and Fas expression , as evidenced by reverse transcriptase polymerase chain reaction and Western blotting . ^^^ Taken together , these findings indicate that MMC induced apoptosis in SNU 16 cells was mediated by caspase 8 , caspase 9 , and caspase 3 activation independently of FasL / Fas interactions . . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The properties of the FADD DD structure are discussed with respect to previously reported mutagenesis data and emerging models for FasL induced FADD recruitment to Fas and caspase 8 activation . . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| In addition , we evaluated the expression of Fas L and caspases FLICE , CPP 32 and ICE either by flow cytometry , immunoblotting , and / or reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ By exploring the Fas pathway in Jurkat cells , we found that both apoptosis inducers acted through Fas , since Fas L , as well as CPP 32 and FLICE were activated . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Staurosporine and H 7 induced cell death in SH SY5Y neuroblastoma cells is associated with caspase 2 and caspase 3 activation , but not with activation of the FAS / FAS L caspase 8 signaling pathway . ^^^ These findings indicate that the Fas / Fas L caspase 8 pathway of cell death signaling is not involved in staurosporine and H 7 induced apoptosis in SH SY5Y neuroblastoma cells . . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The presence of FLIP strongly interfered with FasL induced activation of caspase 8 and caspase 3 preventing subsequent cell death . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Furthermore , upon triggering of cytokine treated cells with FasL , we observed upregulation of the cleavage product of FLIP ( p 43 FLIP ) previously shown to associate with the DISC and to block caspase 8 recruitment , thereby inhibiting Fas mediated death . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The expression pattern of Fas , FasL and FLICE inhibitory protein was comparable in all three cell lines . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Fas mediated and chemotherapy induced apoptosis can converge at the level of the receptor , FasL , DISC formation , activation of the initiator caspase 8 , at the level of the mitochondria , or at the level of downstream effector caspase activation . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Multiplex PCR was used to study the expression pattern of proapoptotic genes such as Fas , FasL , caspase 8 , and Fas associated death domain ( FADD ) . ^^^ IL 18 failed to induce FasL or caspase 8 expressions . ^^^ IL 18 induced Fas expression in amniochorion ; however , it failed to turn on other genes in the Fas FasL apoptosis pathway including FasL and caspase 8 . . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Here , we demonstrate that LPS and TNF alpha up regulate Flip and suppress spontaneous Fas FasL mediated monocyte apoptosis and caspase 8 and 3 activation . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| In addition , proteasome inhibitor induced apoptosis was prevented by the addition of antagonistic anti FasL antibody ( 4A5 ) or z IETD . fmk , a potent inhibitor of caspase 8 , indicating the involvement of the Fas receptor ligand apoptotic signaling system in proteasome inhibitor mediated apoptosis . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Our findings indicate that FADD and Caspase 8 are essential for FasL and TRAIL mediated apoptosis in glioma cells . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| FasL , Fas , FADD , RIP , caspase 8 , caspase 3 , Bid , FLIP ( S+L ) , FLASH and FAP 1 , proteins known to act within the Fas apoptosis cascade , showed no changes in their expression levels in cells treated with butyrate compared with untreated cells . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The involvement of Fas , Fas L , and caspase 8 was studied in the killing of B cell chronic lymphocytic leukemia ( B CLL ) cells by chlorambucil , fludarabine , or gamma radiation . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Importantly , 16 10A1 could retard the growth of lymphomas and favored the up regulation of pro apoptotic molecules caspase 3 , caspase 8 , Fas , FasL , Bak , and Bax and down regulation of anti apoptotic molecule Bcl 10 ( L ) . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Diminished Akt signaling promoted the cleavage of caspase 3 , and both caspase 3 cleavage and FasL induction were inhibited by transduction of dominant negative caspase 9 or the caspase 8 inhibitor CrmA . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The evidence that Fas L ( + ) / TRAIL ( + ) malignant plasma cells prime erythroblast apoptosis by direct cytotoxicity was also supported by the increase of FLICE in fresh immature GpA ( +dim ) erythroid cells , whereas ICE and caspase 10 increased in subsequent maturative forms . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| When triggered by FasL protein , DNA fragmentation and caspase 8 activation were observed in SKOV 3 cells , though they were not as clear as in NOS 4 cells . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Blood and liver were analyzed for plasma aminotransferase activity , liver histology , liver apoptotic nuclei , mRNA of several cytokines ( tumor necrosis factor [ TNF ] alpha , interleukin [ IL ] 1beta , IL 6 , and IL 10 ) , apoptotic ligands ( TRAIL ) , cytokine receptors ( TNFRp 55 ) , pro and antiapoptotic regulators / adaptors ( Fas receptor , FasL , FADD , TRADD , RIP , Bak , Bax , Bcl 10 , Bcl 2 and Bcl w ) , and caspase 8 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : These results ascribe to CCR 5 a novel role in activating the Fas pathway and caspase 8 as well as triggering FasL production when activated by R 5 Env , ultimately causing CD 4 T cell death . . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Neuronal cultures treated with fibrillar Abeta can be protected from neurotoxicity by caspase 8 inhibition or the expression of dominant negative FADD , both of which are components of the Fas death receptor pathway , and neurons with defective Fas and FasL are resistant to Abeta neurotoxicity . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| In addition , vanadate induced FasL production , Fas ( CD 95 ) aggregation , and its association with the Fas associated death domain ( FADD ) , as well as the activation of caspase 8 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Because CASP 8 is a key component of the death inducing signaling complex ( DISC ) when specific death receptors ( including DR 4 , DR 5 , FAS ) are activated by their specific ligands ( TRAIL / FASL ) , we examined expression of the components of the DISC complex in lung cancer cell lines . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| We show that Fas , FasL , Fas associated death domain , and caspase 8 mRNA are detectable in the epidermis , primary keratinocyte cultures , and keratinocyte cell line and that Fas protein is expressed in keratinocytes of all subcorneal layers of the epidermis , whereas FasL is only expressed in the basal and first suprabasal layers . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Fas associated death domain protein ( FADD ) and caspase 8 , components of death inducing signaling complex ( DISC ) , as well as FLIP ( FLICE [ Fas associating protein with death domain like interleukin 1 converting enzyme ] / caspase 8 inhibitory protein ) , a negative regulator of caspase 8 , were expressed ubiquitously in Ph 1 positive leukemia cell lines irrespective of their differential sensitivities to TRAIL and FasL . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| However , in FasL treated cells , ECH was only able to inhibit the activation of pro caspase 8 , and it had no effect on the already activated caspase 8 at a concentration that is effective at inhibiting Fas induced apoptosis . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| METHODS : Expressions of T cell apoptosis promoting and inhibiting genes , including Fas , FasL , Bcl 2 , Bax , TNFR 1 and TNFR 2 , as well as activity of cysteine proteinase in cascade connection , such as Caspase 8 and Caspase 3 were determined by TUNEL labeled flow cytometry and fluorescence real time quantitative RT PCR technique . ^^^ RESULTS : The two compound prescriptions for Kidney tonifying could effectively lower T cell over apoptosis in old rats , down regulate FasL and TNFR 1 gene transcription , and decrease the activity of Caspase 8 and Caspase 3 , while the compound prescription for blood circulation activating showed insignificant effect on T cell over apoptosis . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| RXM accelerated cell death , enhanced expression of FasL and caspase 3 but not caspase 8 , and did not show the concentration dependency . . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Bosentan and / or FasLigand ( FasL ) did not modulate the expression of caspase 8 or FLIP . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| We found that levels of Fas and FasL were up regulated both in vitro and in vivo , accompanying an increase in the expression of caspase 8 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| CONCLUSION : In human endothelial cells , the Fas / FasL system induces both IL 8 and MCP 1 secretions probably via a caspase 8 independent pathway . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| In addition , an association between FasL expression by TCC cells and activated caspase 8 , 9 , and 3 expression by interferon gamma producing CD 8 positive tumor infiltrating lymphocytes was observed in situ . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Cotreatment of SCLC cells with the demethylating agent 5 ' aza 2 deoxycytidine and IFNgamma partially restored Fas , TRAIL R 1 and caspase 8 expression and increased sensitivity to FasL and TRAIL induced death . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Apoptosis of cardiomyocytes in left ventricles was verified using Western blotting based on increased expression of : the apoptosis associated death receptor Fas ( 1 . 5 fold ) ; its ligand ( FasL , 2 . 0 fold ) ; and an upstream protease caspase 8 ( 2 . 7 fold ) as well as its active cleavage peptide , p 20 ( 5 . 6 fold ) . ^^^ Immunohistochemical studies localized FasL and caspase 8 to intercalated discs , suggesting that wall stress may play a role in initiating cardiomyocyte apoptosis . ^^^ CONCLUSION : Apoptosis of cardiomyocytes in chronic HF is associated with increased wall stress , which may be responsible for the activation of a Fas / FasL and caspase 8 interaction in the region of intercalated discs . . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Caspase 8 is an initiator caspase that becomes activated when Fas death receptor Fas ligand ( FasL ) coupling on the cell surface leads to coalescence of a `` death complex ' ' perpetuating the programmed cell death cascade . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Gene expression analysis using real time RT PCR additionally revealed low expression of Fas and FasL , the death receptor system activating caspase 8 and contributing to AICD . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| We also examined the relative importance of mitochondrial damage and direct cleavage of the executioner caspases by activated initiator caspase 8 in the propagation of FasL / Fas signaling activated by either recombinant membrane FasL or H / R . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| LPS stimulation induced the expression of Fas , caspase 8 , cellular FLIP Bfl 1 / A1 , and Bcl 10 , but not FasL , TNFR p 55 , Bak , Bax , and Bad at the transcriptional level . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| An RNase protection assay showed , in the rebamipide administered group , significantly decreased mRNA levels of apoptosis related genes such as caspase 8 , FasL , Fas , TRAIL and various cytokines genes such as IFN gamma , RANTES , TNF alpha , TNFR p 75 , IL 1beta . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| These data support a mechanism for rapid , UVA induced apoptosis in HL 60 cells involving initial formation of the Fas FADD caspase 8 death complex in an FasL independent manner . . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| These results reveal for the first time that P 4 induces apoptosis in HOSE and OVCA cells via activation of a caspase 8 initiated Fas / FasL signaling pathway . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| However , Fas had no role in CsA induced apoptosis , as CsA did not sensitize to FasL induced apoptosis , caspase 8 activity was not increased , and neither blocking anti FasL antibodies nor caspase 8 inhibition prevented CsA induced apoptosis . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| In addition , 2 methoxyestradiol treatment caused upregulation of death receptor ligands FasL and TNFalpha and induced caspase 8 activation . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Testosterone induced apoptosis was associated with the enhanced expression of Fas , FasL , and caspase 8 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Caspase 8 , caspase 9 , FLIP , Fas , FasL , and TNFalpha protein expression was assessed further using Western blot analysis and ELISA . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| We show that PV IgG and an antibody against Fas receptor ( anti FasR ) induce lesions in vitro in a similar way , causing : ( 1 ) secretion of soluble FasL ; ( 2 ) elevated cellular amounts of FasR , FasL ( soluble and membranal ) , Bax and p 53 proteins ; ( 3 ) reduction in levels of cellular Bcl 2 ; ( 4 ) enrichment in caspase 8 , and activation of caspases 1 and 3 ; ( 5 ) co aggregation of FasL and FasR with caspase 8 in membranal death inducing signaling complex ( DISC ) . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Nef oversees apoptotic killing of CD8+ T cells up regulating TNF alpha and FasL production by DCs and interfering with the death receptor pathway in CD8+ T cells and thus activating caspase 8 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| This different response to CDDP in caspase 8 activation was not related with the expression level of either Fas or FasL in these cells . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The death domain of Fas , FADD , and caspase 8 were required for NF kappaB activation by FasL . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| FADD was constitutively expressed in all ( T , B , macrophage , and fibroblast ) cell lines examined as well as in peripheral blood lymphocytes ( PBL ) , whereas FasR and caspase 8 were expressed in all cell lines except CCO , a FasL positive fibroblast line . ^^^ In contrast to FasL , expression of FasR and caspase 8 was inversely proportional to cell density . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Down regulating the expression of FasL and TNFR 1 and up regulating the expression of Bcl 2 as well as decreasing the activities of caspase 8 and caspase 3 may be the unique regulating pattern of tonifying kidney method with respect to T cell apoptosis related genes in corticosterone treated rats . . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The pX dependent expression of Fas / FasL and TNFR1 / TNF alpha mediates caspase 8 activation , resulting in Bid cleavage . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Our results demonstrated that 16 genes ; bad , bax , bcl 2 , bcl w , bcl 10 , caspase 3 , caspase 7 , caspase 8 , c myc , E 124 , GADD 45 , mdm 2 , NKkappab 1 , p 53 , p 21 , Rb and trail were up regulated and six genes ; caspase 1 , caspase 2 , DR 5 , E2F1 , FasL and iNOS did not changed in response to DES treatment in wild type mice compared to p53+ / knockout mice . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| RNase protection assays support the presence of apoptosis in 1yo ArKO hypothalamus , revealing an up regulation of pro apoptotic genes : FASL , FADD , and caspase 8 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Examination of luteal tissue for FasL / Fas death receptor cascade revealed increased expression of FasL and Fas at 18 h accompanied by a significant ( p < 0 . 05 ) induction in the caspase 8 activity and truncated Bid levels . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| FasL cross links its receptor Fas , resulting in recruitment and proteolytic activation of caspase 8 , which initiates the downstream apoptotic cascade . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Akt inhibition upregulates FasL , downregulates c FLIPs and induces caspase 8 dependent cell death in Jurkat T lymphocytes . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| In contrast to caspase 8 , controversy exists as to the ability of caspase 10 to mediate apoptosis in response to FasL . ^^^ Herein , we have shown activation of caspase 10 , 3 , and 7 as well as B cell lymphoma 2 interacting domain ( Bid ) cleavage and cytochrome c release in caspase 8 deficient Jurkat ( I 9 2 ) cells treated with FasL . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Membrane FasL induced Fas clusters were formed in caspase 8 or FADD deficient cells or when a cytoplasmic deletion mutant of Fas was used suggesting that cluster formation is independent of the assembly of the cytoplasmic Fas signaling complex and downstream activated signaling pathways . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Pre treatment of cells with a Fas L neutralizing antibody abrogated DOX induced caspase 8 and 3 like activities during the initial stages of apoptosis . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Following treatment with 50 nM FasL , apoptosis , caspase 8 activity , and cell surface Fas receptor were measured by cytosolic nucleosome ELISA , colorimetric enzyme assay , and immunofluorescence analysis , respectively . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Associated with the activation of Fas FasL was the activation of nuclear factor kappaB and induction of Fas associated factor 1 , Fas associated death domain , and caspase 8 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Western blotting and RT PCR were performed to detect the expression changes of Fas , FasL , caspase 10 p 20 , caspase 8 , 1 kappaB alpha , and p 1 kappaB alpha molecules in protein and mRNA levels , separately , and immunohistochemistry for molecular localization of Fas and FasL in rat hippocampus . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| In addition , testosterone decreased cell viability by way of apoptosis , accompanied by increased Fas , FasL , and Caspase 8 expression . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Using PKC ( zeta ) overexpressing cells or si RNA depletion , we demonstrate that PKC ( zeta ) interferes neither with Fas expression nor Fas clustering in raft microdomains , but negatively regulates FasL induced apoptosis by interfering with DISC formation and subsequent caspase 8 processing . . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Our results indicated that MMC induced apoptosis in SiHa / pRSV luc and SiHa cells via caspase 8 and 3 processing , in a Fas / FasL dependent manner . ^^^ These results suggest that MMC induces apoptosis , not only through caspase 8 and 3 dependent Fas / FasL pathway , but also via the regulation of NF kappaB activity and IL 18 expression . . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Reduction of endogenous LFG expression by antisense oligonucleotides or small interfering RNA lead to increased sensitivity of CGNs to FasL induced cell death and caspase 8 cleavage . ^^^ The inhibition of PI 3 kinase activity sensitized CGNs to FasL induced caspase 8 and caspase 3 processing and caspase dependent fodrin cleavage . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry was performed for cell cycle regulators [ p 53 , p 21 , p 27 , p 16 , cyclin D 1 , Rb ] , apoptosis related proteins [ Fas , Fas L , FADD , TRAIL , DR 4 , DR 5 , caspase 8 , caspase 3 , bcl 2 , Bax ] , tumor suppressor proteins [ beta catenin , E cadherin , FHIT , Smad 4 , VHL , PTEN , KAI 1 ] , and oncoproteins [ c myc , COX 2 , EGFR ] . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The number of apoptotic cells in lung sections was determined by a TUNEL method . mRNAs for Fas , FasL and caspase 8 , and for Bad , Bax , Bcl w , Bcl xL and caspase 9 , for the FasL and the mitochondrial cytochrome c pathways of apoptosis , respectively , and mRNA for the effector caspase 3 were quantified in lung tissues by RT PCR . ^^^ RESULTS : After 3 hours of allogeneic perfusion , we observed a significant increase in : 1 ) the number of apoptotic cells in lung sections , 2 ) mRNA levels of FasL , Bcl xL , caspase 8 and caspase 3 , and 3 ) PTP activity ( P < 0 . 05 compared with isogeneic perfusion ) . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Western analysis showed that mature red cells contain Fas , FasL , Fas associated death domain ( FADD ) , caspase 8 , and caspase 3 . ^^^ Circulating , aged cells showed colocalization of Fas with the raft marker proteins Galpha ( s ) and CD 59 ; the existence of Fas associated FasL , FADD and caspase 8 ; and caspase 8 and caspase 3 activity . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The levels of FasL and caspase 8 activity in TLR2 / CHO and TLR4 / CHO cells were significantly higher than that of CHO cells . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| According to the above mentioned observations , OHT but not ICI clearly induced a marked expression of FasL and the cleavage of both caspase 8 and caspase 3 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| FLIP down regulation as well as caspase 8 activation and apoptosis induced by FasL were all inhibited by the NO liberating agent sodium nitroprusside and dipropylenetriamine NONOate , whereas the NO synthase inhibitor aminoguanidine and NO scavenger 2 ( 4 carboxyphenyl ) 4 , 4 , 5 , 5 tetramethyl imidazoline 1 oxyl 3 oxide ( PTIO ) had opposite effects , indicating an anti apoptotic role of NO in the Fas signaling process . ^^^ Here we show that stimulation of the Fas receptor by its ligand ( FasL ) results in rapid generation of NO and concomitant decrease in cellular FLICE inhibitory protein ( FLIP ) expression without significant effect on Fas and Fas associated death domain ( FADD ) adapter protein levels . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Glutathione and inhibitors of caspase 8 or caspase 9 , but not of FasL , inhibited these effects , suggesting their dependence on ROS , caspase 8 and 9 , in a Fas / FasL independent pathway . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Despite exhibiting similar binding to both Fas and caspase 8 and preserved overall secondary structure , FADD RDXLL motif mutants can not reconstitute FasL or TRAIL induced apoptosis and fail to recruit caspase 8 into the DISC of reconstituted FADD deficient cells . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| However , blocking the FasR FasL interaction by antagonistic antibodies to FasR or to FasL had no effect on P . aeruginosa induced caspase 8 and caspase 3 activation , neither did the silencing of FasR by small interfering RNA ( siRNA ) , suggesting that caspase 8 activation through the FADD bypasses FasR / FasL mediated signalling . ^^^ Furthermore , silencing of caspase 8 by siRNA did not interfere with P . aeruginosa induced apoptosis , whereas it rendered HeLa cells markedly increased resistance towards FasL induced apoptosis . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Blockade of NFkappaB by helenalin resulted in down regulation of FasL whereas a caspase 8 inhibitor did not decrease FasL . ^^^ Taken together , these studies show that P . gingivalis can induce epithelial cell apoptosis through Fas FasL up regulation and activation of caspase 3 and caspase 8 . . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| JNK and AP 1 mediate apoptosis induced by bortezomib in HepG 2 cells via FasL / caspase 8 and mitochondria dependent pathways . ^^^ These events include accumulation of c Jun , phospho c Jun and p 53 ; increase in FasL level with activation of caspase 8 ; changes related to members of Bcl 2 family with increase in the level of pro apoptotic members and decrease in that of anti apoptotic ones ; dissipation of mitochondrial potential with cytochrome c release and activation of caspase 3 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| In addition , EPO reduced the mRNA level of TNF alpha , Fas and Fas L , as well as the activities of caspase 8 , 9 and 3 . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| OxLDL induced the expression of Fas and FasL , and the subsequent caspase 8 cleavage and treatment with a neutralizing ZB 4 anti Fas antibody blocked apoptosis induced by OxLDL . ^^^ These findings suggest that A 20 mediated protection from OxLDL may occur at the level of Fas / FADD caspase 8 and be FasL dependent . ^^^ Thus , A 20 expression blocks OxLDL mediated apoptosis in murine RAW264 . 7 macrophages through disrupting Fas / FasL dependent activation of caspase 8 and the mitochondria pathway . . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| MAIN OUTCOME MEASURE ( S ) : Apoptosis was determined using TUNEL ( terminal deoxynucleotidyl transferase biotin dUTP nick end labeling ) assay and p 53 , p 27 , Bax , caspase 3 , caspase 8 , caspase 9 , Fas L , Bcl 2 , GATA 4 , Ki 67 , proliferating cell nuclear antigen ( PCNA ) , estrogen receptor , P receptor , and androgen receptor expression by immunohistochemistry . ^^^ DNA fragmentation and expression of Bax , caspase 3 , caspase 8 , caspase 9 , Fas L , Bcl 2 , GATA 4 , Ki 67 , and PCNA were observed in the whole ovary in both groups . ^^^ |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|