| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.59411473 |
| Fas expression was examined by RT PCR and Fas ligand , Fas associated protein with death domain ( FADD ) and poly ADP ribose polymerase ( PARP ) cleavage were examined by Western blot analysis . 0.59411473^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Cell death induced by the overexpression of Fas ligand , Fas associated death domain containing protein ( FADD ) / MORT1 , or FADD like interleukin 1beta converting enzyme ( FLICE ) / caspase 8 in a virus free system was efficiently blocked by 14 . 7K expression . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| This report analyzes the gene expression of bcl xs , bcl xl , bax alpha , bax beta , fadd , fas , fas ligand ( fas L ) , ice , TNF alpha , TNF beta , TNFR 1 , TNFR 2 , TRAF 1 , TRAF 2 , TRAF 3 , cIAP 2 , and tradd at the level of mRNA in the single Reed Sternberg cells and their variants . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Expression of RICK promoted the activation of caspase 8 and potentiated apoptosis induced by Fas ligand , FADD , CLARP , and caspase 8 . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| These resistant U 251 transfectants were susceptible to FADD adenovirus ( Adeno FADD ) induced apoptosis , indicating that a cascade of death signals was blocked at the steps between Fas ligand and FADD . ^^^ Our data suggest the possibility of using adenovirus mediated transduction of Fas ligand and FADD genes as a therapeutic approach to target gliomas . . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Fas ligand independent , FADD mediated activation of the Fas death pathway by anticancer drugs . ^^^ These results suggest that drug induced cell death involves the Fas / FADD pathway in a Fas ligand independent fashion . . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| The ATP depleted cells display a significant upregulation of Fas , Fas ligand , and the Fas associating protein with death domain ( FADD ) . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| However , Fas resistant cells showed reduced expression of FADD , Fas ligand , and caspases 3 , 7 , and 8 and increased expression of FLIP and c IAP 1 . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| FADD ( also known as MORT 1 ) is an essential adapter protein that couples the transmembrane receptors Fas ( CD 95 ) and tumor necrosis factor receptor 1 ( TNF R 1 ) to intracellular cysteine proteases known as caspases , which propagate and execute the programmed cell death inducing signal triggered by Fas ligand ( FasL , CD95L ) and TNF . ^^^ FADD ( also known as MORT 1 ) is an essential adapter protein that couples the transmembrane receptors Fas ( CD 95 ) and tumor necrosis factor receptor 1 ( TNF R 1 ) to intracellular cysteine proteases known as caspases , which propagate and execute the programmed cell death inducing signal triggered by Fas ligand ( FasL , CD95L ) and TNF . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| These families may include receptor / ligand molecules such as Fas , Fas ligand , tumor necrosis factor receptor 1 ( TNFR 1 ) , and TNF related apoptosis inducing ligand ( TRAIL ) ; signal transduction adapter molecules such as Fas associated death domain ( FADD ) , TNFR 1 associated death domain ( TRADD ) , receptor interacting protein ( RIP ) , Fas associated factor ( FAF ) , and Fas associated phosphatase ( FAP ) ; or effector molecules such as caspases . ^^^ To detect the expression of apoptosis related molecules , ribonuclease protection assay was used with specific antisense RNA probes for Fas , Fas ligand , TNFR 1 , TRAIL , FADD , TRADD , RIP , FAF , FAP , and caspase 8 . ^^^ Compared with control and contralateral kidneys , the ligated kidneys displayed a dynamic expression of mRNAs for many apoptosis related molecules , which included an up to threefold increase for Fas , Fas ligand , TNF R 1 , TRAIL , TRADD , RIP , and caspase 8 , and an up to twofold increase for FADD and FAP , but there was little change for FAF . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Jun NH 2 terminal kinase activation leads to a FADD dependent but Fas ligand independent cell death in Jurkat T cells . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Silicon phthalocyanine 4 photodynamic therapy also resulted in a time dependent increase in ( 1 ) the multimerization of Fas protein , ( 2 ) the protein expression of Fas ligand , ( 3 ) FADD , an adapter molecule for Fas , and ( 4 ) the binding of FADD with Fas . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Western blots were used to determine expression of the components involved in the initiation ( Fas , Fas Ligand , FADD ) , regulation ( Bcl 2 , Bax ) and execution ( caspase 2 and caspase 3 ) of apoptosis . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Under such conditions , Fas , Fas ligand , Bax , and p 21 expression were increased and Fas recruited the FADD adaptor . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Fas associated death domain protein ( FADD ) and caspase 8 mediate up regulation of c Fos by Fas ligand and tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) via a FLICE inhibitory protein ( FLIP ) regulated pathway . ^^^ Fas associated death domain protein ( FADD ) and caspase 8 mediate up regulation of c Fos by Fas ligand and tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) via a FLICE inhibitory protein ( FLIP ) regulated pathway . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Fas , Fas ligand , and an intracellular adaptor protein , Fas associating protein with death domain ( FADD ) expression , and poly ADP ribose polymerase ( PARP ) cleavage were also studied . ^^^ In alpha MSH co treated cells , apoptosis markedly decreased with downregulation of Fas , Fas ligand and FADD expressions and also the cleavage product of PARP . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Expression of TNF receptor 55 and TNF receptor associated death domain ( TRADD ) was increased , with no changes in Fas signaling molecules , Fas , Fas ligand ( FasL ) , Fas associated death domain ( FADD ) and Fas associated protein factor ( FAF ) . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Wild type FADD rescued both Fas ligand and TNF dependent signaling , whereas the FADD death effector domain mutants rescued only TNF signaling . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Ligation of Fas by Fas ligand or an anti Fas cross linking antibody triggers receptor trimerization followed by recruitment of FADD to the cytoplasmic domain of the receptor and the activation of the caspase cascade . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| The other components of the Death Inducing Signalling Complex ( DISC ) , FADD , and procaspase 8 , were also present at higher levels in the raft fraction isolated from Fas ligand treated cells . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Interferon gamma ( IFNgamma ) acts on human erythroid colony forming cells ( ECFCs ) to up regulate Fas , without a demonstrable change of Fas ligand ( FasL ) or Fas associated DD containing protein ( FADD ) expression and activates caspase 8 plus caspase 3 , which produce apoptosis . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| On the other hand , treating HUVECs with Ox LDL did not lead to any significant change in the expression of death mediators , including Fas , Fas ligand ( FasL ) , FADD , and FLICE as assessed by multiplex polymerase chain reaction amplification . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Upon engagement with Fas ligand ( FasL ) , Fas rapidly induces recruitment and self processing of caspase 8 via the adaptor protein Fas associated death domain ( FADD ) , and activated caspase 8 cleaves downstream substrates such as caspase 3 . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| This review focuses on novel strategies to induce apoptosis in glioma cells by transduction with adenoviral vectors carrying a variety of apoptosis related genes , including Fas ligand , Fas , FADD , caspase 8 , p 53 , p33ING1 , p73alpha , Bax , Apaf 1 , caspase 9 , IkappaBdN , caspase 3 , Bcl 2 , and Bcl 10 ( L ) . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| There were significant positive correlations between the Fas ligand and the FADD , ICE , or CPP 32 levels in the liver . ^^^ The expression of Fas , Fas ligand , FADD , ICE , or CPP 32 correlated with serum markers of hepatic injury . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| We previously reported that treatment of human vascular smooth muscle cells ( SMCs ) with proapoptotic stimuli , including Fas ligand plus cycloheximide ( FasL / Chx ) , or overexpression of Fas associated death domain protein ( FADD ) result in increased expression of monocyte chemoattractant protein 1 ( MCP 1 ) and other proinflammatory genes . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Interestingly , expression of dominant negative FADD and treatment with caspase 8 inhibitor efficiently prevented TGF beta 1 induced apoptosis , whereas the treatment with an activating CH 11 or a neutralizing ZB 4 anti Fas antibody , recombinant Fas ligand , or Fas Fc chimera did not affect activation of Fas and the subsequent induction of apoptosis by TGF beta 1 . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Myocardial injury was determined by triphenyltetrazolium chloride ( TTC ) staining , terminal deoxynucleotidyl transferase mediated dUTP nick end labeling ( TUNEL ) , bax , bcl 2 , poly ( ADP ) ribose polymerase ( PARP ) cleavage , caspase 3 , 8 , and 9 cleavage and activity , Fas ligand ( FasL ) , and Fas activated death domain ( FADD ) . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| We observed increased levels of several Fas mediated apoptosis effectors ( Fas , Fas ligand , FADD , FLICE ) , both in cell cultures at advanced passages and in skin cells of aged donors ( above 45 years ) . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Fas , Fas ligand ( FasL ) , and Fas associating death domain containing protein ( FADD ) were clearly up regulated within 48 hours of T treatment in HK 2 cells . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Furthermore , treatment with 20 microM gamma tocotrienol had no effect on total , membrane , or cytosolic levels of Fas , Fas ligand ( FasL ) , or Fas associated via death domain ( FADD ) and did not induce translocation of Fas , FasL , or FADD from the cytosolic to the membrane fraction , providing additional evidence that tocotrienol induced caspase 8 activation is not associated with death receptor apoptotic signaling . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Apoptosis related factors ( Fas receptor , Fas ligand , FADD ) in early tooth development of the field vole ( Microtus agrestis ) . ^^^ Fas ligand binding followed by Fas receptor oligomerisation leads to formation of a death inducing signal complex starting with recruitment of the Fas adapter protein ( FADD ) . ^^^ Frontal sections of the field vole at stage 13 . 5 15 . 5 of embryonic development were exploited to investigate and correlate location of Fas , Fas ligand , FADD molecules and apoptosis in developing first molars by immunohistochemistry . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Activation of several cell death programs represented by Fas ligand , FADD ( Fas Associated Death Domain / Mort1 ) and the caspase cascade ( caspase 8 and 3 ) and survival programs represented by phosphorylated protein kinase B ( PKB / Akt ) , Bcl 2 associated death domain ( BAD ) , and cAMP responsive element binding protein ( CREB ) were examined using immunohistochemistry and Western blotting . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| CD95L expressing H 9 cells killed CD 95 sensitive J 16 or CEM target cells , but not CD 95 resistant CEM or J 16 cells overexpressing dominant negative FADD ( J16 / FADD DN ) . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| We found that GC B cells ex vivo display a preformed inactive DISC containing Fas associated death domain containing protein ( FADD ) , procaspase 8 , and the long isoform of cellular FADD like IL 1beta converting enzyme inhibitory protein ( c FLIP ( L ) ) but not the CD95L . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Indeed , we found that treatment of Jurkat cells with 3 , 4 , 5 THS , unlike treatment with resveratrol , induced activation of caspase 8 and apoptosis by a Fas associated death domain ( FADD ) protein dependent mechanism without involving the known death ligands CD 95 ligand ( CD95L ) , tumor necrosis factor alpha ( TNFalpha ) and TNF related apoptosis inducing ligand ( TRAIL ) . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Since CHX treatment did not result in the induction of Fas or FasL , and neutralizing anti Fas and anti tumor necrosis factor receptor 1 antibodies did not block CHX mediated apoptosis , these results may also indicate that FADD functions in a receptor independent manner . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| These results indicate that IFNgamma acts on ECFC not only to upregulate Fas , but also to selectively upregulate caspases 1 , 3 , and 8 , which are activated and produce apoptosis , whereas the concentrations of FasL and FADD are not demonstrably changed . . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| We show that lymphocytes that can not be killed by FasL , such as those from Fas deficient lpr mice or transgenic mice expressing a dominant negative mutant of Fas associated death domain protein ( FADD / MORT1 ) , are as sensitive as normal lymphocytes to killing by gamma radiation or the cytotoxic drugs cis platin , doxorubicin , and etoposide . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Activation of Fas ( CD 95 ) by its ligand ( FasL ) rapidly induces cell death through recruitment and activation of caspase 8 via the adaptor protein Fas associated death domain protein ( FADD ) . ^^^ RESULTS : Under conditions in which proliferation of CD 3 activated human T lymphocytes is increased by recombinant FasL , there was activation of the transcription factors NF kappaB and AP 1 and recruitment of the caspase 8 inhibitor and FADD interacting protein FLIP ( FLICE like inhibitory protein ) . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Thus , Apo2L / TRAIL and FasL initiate apoptosis through similar mechanisms , and FADD may be a universal adaptor for death receptors . . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| However , unlike FADD / and caspase 8 / cells , casper / embryonic fibroblasts are highly sensitive to FasL or TNF induced apoptosis and show rapid induction of caspase activities . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Stress serum treated NCC obtained from the peripheral blood produced an increase in the expression of FasL , CAS and FADD by Western blot examination . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Up regulation of surface FasL expression , accompanied by a down regulation of Fas associated proteins ( FADD , DAXX , and RIP ) , was observed 72 h after infection . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| The infection led to activation of FasL ; however , a transdominant mutant of FAS downstream death domain protein , FADD , did not inhibit apoptosis . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| For transduction of APCs we prepared recombinant attenuated vaccinia virus vectors carrying the following three gene constructs : ( 1 ) AChR fused to LAMP 1 to present AChR and target AChR specific T cells ; ( 2 ) FasL to eliminate the targeted T cells ; and ( 3 ) truncated FADD to protect APCs from self destruction by FasL . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Multiplex PCR was used to study the expression pattern of proapoptotic genes such as Fas , FasL , caspase 8 , and Fas associated death domain ( FADD ) . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Our findings indicate that FADD and Caspase 8 are essential for FasL and TRAIL mediated apoptosis in glioma cells . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| FasL , Fas , FADD , RIP , caspase 8 , caspase 3 , Bid , FLIP ( S+L ) , FLASH and FAP 1 , proteins known to act within the Fas apoptosis cascade , showed no changes in their expression levels in cells treated with butyrate compared with untreated cells . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| CAS , FADD ) and soluble FasL . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Inhibition of Fas / FasL pathway by anti FasL antibody , mutant Fas or a dominant negative FADD blocks paclitaxel induced apoptosis . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Blood and liver were analyzed for plasma aminotransferase activity , liver histology , liver apoptotic nuclei , mRNA of several cytokines ( tumor necrosis factor [ TNF ] alpha , interleukin [ IL ] 1beta , IL 6 , and IL 10 ) , apoptotic ligands ( TRAIL ) , cytokine receptors ( TNFRp 55 ) , pro and antiapoptotic regulators / adaptors ( Fas receptor , FasL , FADD , TRADD , RIP , Bak , Bax , Bcl 10 , Bcl 2 and Bcl w ) , and caspase 8 . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Neuronal cultures treated with fibrillar Abeta can be protected from neurotoxicity by caspase 8 inhibition or the expression of dominant negative FADD , both of which are components of the Fas death receptor pathway , and neurons with defective Fas and FasL are resistant to Abeta neurotoxicity . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| In addition , vanadate induced FasL production , Fas ( CD 95 ) aggregation , and its association with the Fas associated death domain ( FADD ) , as well as the activation of caspase 8 . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Fas associated death domain protein ( FADD ) and caspase 8 , components of death inducing signaling complex ( DISC ) , as well as FLIP ( FLICE [ Fas associating protein with death domain like interleukin 1 converting enzyme ] / caspase 8 inhibitory protein ) , a negative regulator of caspase 8 , were expressed ubiquitously in Ph 1 positive leukemia cell lines irrespective of their differential sensitivities to TRAIL and FasL . ^^^ Fas associated death domain protein ( FADD ) and caspase 8 , components of death inducing signaling complex ( DISC ) , as well as FLIP ( FLICE [ Fas associating protein with death domain like interleukin 1 converting enzyme ] / caspase 8 inhibitory protein ) , a negative regulator of caspase 8 , were expressed ubiquitously in Ph 1 positive leukemia cell lines irrespective of their differential sensitivities to TRAIL and FasL . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| In an in depth study of the Fas / FasL signaling pathway in thyroid tumor development , we have demonstrated that tumor cells specifically downregulate the multideath receptor adapter Fas associated death domain ( FADD ) . ^^^ Since thyrocytes also acquired FasL expression during tumor development , the absence of FADD protein could lead to greater resistance to numerous death receptor mediated apoptosis , stimulation of their own proliferation through Fas / FasL interaction , and the capacity to counter attack the infiltrating lymphocytes . . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| These data support a mechanism for rapid , UVA induced apoptosis in HL 60 cells involving initial formation of the Fas FADD caspase 8 death complex in an FasL independent manner . . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| The expression patterns of pro apoptotic genes ( Fas , FasL , TRADD , FADD ) and caspases 2 , 3 , 8 , 9 were studied using PCR . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Expression of membrane bound and soluble FasL in Fas and FADD dependent T lymphocyte apoptosis induced by mildly oxidized LDL . ^^^ Altogether , our results highlight the putative role of both membrane bound and soluble FasL in oxLDL induced Fas and FADD dependent apoptosis of T lymphocytes and suggest an involvement of ROS , ERK , and JNK in this process . . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| The level of apoptosis induction was reduced using a neutralizing anti FasL antibody and overexpression of either the dominant negative FADD or the viral FLICE inhibitory protein . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| The death domain of Fas , FADD , and caspase 8 were required for NF kappaB activation by FasL . ^^^ In addition , we found that mouse FADD had a dominant negative effect on the FasL induced NF kappaB activation in HEK 293 cells , which may indicate a species difference between human and mouse in the FasL induced NF kappaB activation . . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| FADD was constitutively expressed in all ( T , B , macrophage , and fibroblast ) cell lines examined as well as in peripheral blood lymphocytes ( PBL ) , whereas FasR and caspase 8 were expressed in all cell lines except CCO , a FasL positive fibroblast line . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| RNase protection assays support the presence of apoptosis in 1yo ArKO hypothalamus , revealing an up regulation of pro apoptotic genes : FASL , FADD , and caspase 8 . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| In this study , we observed that inhibition of Akt causes enhanced expression of FasL mRNA and protein and increased death inducing signaling complex ( DISC ) formation with Fas associated death domain ( FADD ) and procaspase 8 recruitment . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| The major finding are as following : ( 1 ) The mechanical stretch activated death receptor mediated apoptotic signaling in cardiomyocytes , including activation of caspases 8 , 9 and 3 , up regulation of Fas , FasL expression and cell surface trafficking of death ligands ( FasL and TRAIL ) ; ( 2 ) That exogenous death ligand ( TRAIL ) enhanced , while soluble death receptor ( sDR 5 ) neutralized , stretch induced apoptosis ; ( 3 ) Adenovirus delivered dominant negative FADD ( FADD DN ) significantly reduced apoptosis , caspases 8 , 9 , and 3 activation , and stretch induced cyt c release from mitochondria . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| AIM : To evaluate the expressions of apoptotic signal proteins FADD , TRADD , FasL , Fas , and NFkappaB in gastric carcinoma tissues and their clinical significance . ^^^ METHODS : Western blot immune trace method was adopted to detect the expressions of apoptotic signal proteins FADD , TRADD , FasL , Fas , and NFkappaB in 55 tissue specimens of gastric carcinoma . ^^^ Expressions of the FADD , FasL , Fas , and NFkappaB proteins reduced with increase of the volume of tumor with the exception of increased expression the TRADD protein ( 64 . 7 71 . 1 % , P = 0 . 031 ) . ^^^ With gradual increase of the malignancy of gastric carcinoma tissues , expressions of the FADD , FasL , and Fas proteins decreased ( 78 . 6 28 . 0 % , P = 0 . 008 ; 78 . 6 65 . 9 % , P = 0 . 071 ; 100 . 0 46 . 3 % , P = 0 . 014 ) , while expressions of the TRADD and NFkappaB proteins increased ( 42 . 9 78 . 1 % , P = 0 . 063 ; 78 . 6 79 . 1 % , P = 0 . 134 ) . ^^^ With gradual increase of serum CEA , expression of the FADD protein decreased ( 62 . 5 34 . 0 % , P = 0 . 073 ) , but expressions of the TRADD , FasL , Fas , and NFkappaB proteins increased ( 0 . 0 80 . 8 % , P = 0 . 005 ; 62 . 5 70 . 2 % , P = 0 . 093 ; 0 . 0 70 . 2 % , P = 0 . 003 ; 62 . 5 80 . 9 % , P = 0 . 075 ) . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| The expression levels of Fas , FasL , and FADD were not changed by the treatment with cisplatin . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| In this report , we have engineered the FasL and FADD genes into pC 8 36 and demonstrated their efficacy for the treatment of human gliomas in vitro and in vivo . ^^^ Furthermore , the incorporation of both FasL and FADD into pC 8 36 resulted in the enhancement of apoptosis in the target glioma cells both in vitro and in vivo . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry was performed for cell cycle regulators [ p 53 , p 21 , p 27 , p 16 , cyclin D 1 , Rb ] , apoptosis related proteins [ Fas , Fas L , FADD , TRAIL , DR 4 , DR 5 , caspase 8 , caspase 3 , bcl 2 , Bax ] , tumor suppressor proteins [ beta catenin , E cadherin , FHIT , Smad 4 , VHL , PTEN , KAI 1 ] , and oncoproteins [ c myc , COX 2 , EGFR ] . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Western analysis showed that mature red cells contain Fas , FasL , Fas associated death domain ( FADD ) , caspase 8 , and caspase 3 . ^^^ Circulating , aged cells showed colocalization of Fas with the raft marker proteins Galpha ( s ) and CD 59 ; the existence of Fas associated FasL , FADD and caspase 8 ; and caspase 8 and caspase 3 activity . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Here we show that stimulation of the Fas receptor by its ligand ( FasL ) results in rapid generation of NO and concomitant decrease in cellular FLICE inhibitory protein ( FLIP ) expression without significant effect on Fas and Fas associated death domain ( FADD ) adapter protein levels . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| In contrast , FADD ( / ) Jurkat T cells are resistant to FasL and Trail but die of necrosis when incubated with TNF alpha . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Moreover , treatment with cytotoxic doses of alpha tocotrienol did not alter the intracellular levels of Fas , FasL , or Fas associated death domain ( FADD ) in these cells . ^^^ Western blot analysis also showed that alpha tocotrienol did not induce FasL or FADD translocation from the cytosolic to membrane fraction in these cells . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Despite exhibiting similar binding to both Fas and caspase 8 and preserved overall secondary structure , FADD RDXLL motif mutants can not reconstitute FasL or TRAIL induced apoptosis and fail to recruit caspase 8 into the DISC of reconstituted FADD deficient cells . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| However , blocking the FasR FasL interaction by antagonistic antibodies to FasR or to FasL had no effect on P . aeruginosa induced caspase 8 and caspase 3 activation , neither did the silencing of FasR by small interfering RNA ( siRNA ) , suggesting that caspase 8 activation through the FADD bypasses FasR / FasL mediated signalling . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Hepatic mRNA levels were measured for several pro apoptotic adaptors / regulators , including FasL , Fas receptor , FADD , TRADD , Bad , Bak , Bax , and Bcl 10 ( S ) , and anti apoptotic regulators , including Bcl w , Bcl 10 ( L ) , Bcl 2 , and Bfl 1 . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| These findings suggest that A 20 mediated protection from OxLDL may occur at the level of Fas / FADD caspase 8 and be FasL dependent . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis showed the up regulated expression of Fas , FasL , and FADD , and down regulated expression of procaspase 8 , suggesting that Fas / FasL pathway was activated in oridonin induced cell apoptosis . ^^^ |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48023 and Q13158 |
Pubmed |
SVM Score :0.0 |
| NA |
|