| Interacting proteins: Q12923 and P48023 |
Pubmed |
SVM Score :0.0 |
| Both Th 1 and Th 2 effectors express Fas and FasL , but only Th 2 effectors express high levels of FAP 1 , a Fas associated phosphatase that may act to inhibit Fas signaling . ^^^ |
|
| Interacting proteins: Q12923 and P48023 |
Pubmed |
SVM Score :0.0 |
| Furthermore , in tumor necrosis factor alpha ( TNF alpha ) treated HL 60 promyelocytic cells , a definite periodicity in the expression of different mRNAs was observed with upregulation of TNF alpha itself at 30 minutes , increased expression of Fas and the appearance of Fas L after 2 hours , and a decrease in Fap 1 expression after 8 hours . ^^^ |
|
| Interacting proteins: Q12923 and P48023 |
Pubmed |
SVM Score :0.0 |
| This Fas resistance did not correlated with high levels of mRNA either for DcR 3 , a decoy receptor for FasL , or for FAP 1 , a Fas associated phosphatase that can block the apoptotic function of Fas . ^^^ |
|
| Interacting proteins: Q12923 and P48023 |
Pubmed |
SVM Score :0.0 |
| FasL , Fas , FADD , RIP , caspase 8 , caspase 3 , Bid , FLIP ( S+L ) , FLASH and FAP 1 , proteins known to act within the Fas apoptosis cascade , showed no changes in their expression levels in cells treated with butyrate compared with untreated cells . ^^^ |
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| Interacting proteins: Q12923 and P48023 |
Pubmed |
SVM Score :0.0 |
| To shed more light on the role of the Fas / FasL pathway in the development of human testicular germ cell tumours of the adult testis , this study investigated the presence of Fas , FasL , Fap 1 , HLA class 1 and 2 molecules , CD 45 ( lymphocyte marker ) , and CD 57 [ natural killer ( NK ) cell marker ] by immunohistochemistry on frozen sections of 41 cases of seminomas , non seminomas , and spermatocytic seminomas . ^^^ This study indicates that production of FasL by the germ cell tumour cells might be involved in the early development of these types of adult testicular cancer by inducting apoptosis of Fas positive , Fap 1 negative tumour infiltrating lymphocytes . . ^^^ |
|
| Interacting proteins: Q12923 and P48023 |
Pubmed |
SVM Score :0.0 |
| Both Fas ligand and Fas associated phosphatase 1 ( FAP 1 ) were expressed only in COLO320DM . ^^^ These results indicated that ( 1 ) Fas antigen was variably expressed , regardless of the p 53 gene status and ( 2 ) the susceptibility to anti Fas antibody mediated apoptosis did not correlate to Fas , Fas ligand or FAP 1 expression levels . ^^^ |
|
| Interacting proteins: Q12923 and P48023 |
Pubmed |
SVM Score :0.0 |
| FAP 1 , FasR , and Fas ligand ( FasL ) were detected using immunohistochemistry . ^^^ In vivo , a positive correlation between the percentage of apoptotic tumour cells and the number of FasL positive tumour infiltrating lymphocytes was observed in FAP 1 negative cancers , but not in FAP 1 positive ones . ^^^ |
|
| Interacting proteins: Q12923 and P48023 |
Pubmed |
SVM Score :0.0 |
| FAP 1 binds to FAS in a ligand dependent manner and forms a signaling complex that modulates the ability of astrocytoma cells to undergo FAS ligand ( FASL ) mediated cell death . ^^^ |
|
| Interacting proteins: Q12923 and P48023 |
Pubmed |
SVM Score :0.0 |
| Opposite roles of FAP 1 and dynamin in the regulation of Fas ( CD 95 ) translocation to the cell surface and susceptibility to Fas ligand mediated apoptosis . ^^^ |
|
| Interacting proteins: Q12923 and P48023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12923 and P48023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12923 and P48023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12923 and P48023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12923 and P48023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12923 and P48023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12923 and P48023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12923 and P48023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12923 and P48023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12923 and P48023 |
Pubmed |
SVM Score :0.0 |
| NA |
|