Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.84520518
Interaction of Fas ligand ( FasL ) with Fas ( CD 95 ) results in lymphocyte apoptosis , and increased susceptibility to Fas mediated apoptosis has been demonstrated in lymphocytes from HIV infected individuals . 0.84520518^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.72059682
However , interactions between Fas and Fas ligand can also yield a costimulatory signal . 0.72059682^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.52626524
BACKGROUND : The transmembrane receptor Fas , together with its protein binding partner ( Fas ligand ) , is a key regulator of programmed cell death ( i . e . , apoptosis ) . 0.52626524^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.71603988
Fas ligand binds to its receptor Fas , thus inducing apoptosis of Fas bearing cells . 0.71603988^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.7848269
Using a series of chimeric Fc receptor fusion proteins between the human Fas receptor and TNFR 1 , each cysteine rich domain of Fas was found to be required for interaction with the Fas ligand . 0.7848269^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.50099561
The Fas system mediated death signal requires the interaction of Fas ligand with Fas on target cells . 0.50099561^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.72474567
Evidence exists that the life span of mature , circulating neutrophils is influenced by apoptosis induced by interactions between Fas ligand ( FasL ) and Fas ( CD 95 ) . 0.72474567^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.62435135
The interaction of Fas with Fas ligand ( FasL ) mediates activation induced cell death ( AICD ) of T hybridomas and of mature T lymphocytes . 0.62435135^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.66790239
Interactions between soluble Fas , tumor necrosis factor alpha ( TNF alpha ) and Fas ligand have been reported to play a pivotal part in signal transduction of apoptosis . 0.66790239^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.51859478
The data suggest that up regulated RTC Fas binds to Fas ligand on adjacent RTCs , which then leads to RTC death by fratricide . 0.51859478^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.66841538
This Fas decoy receptor ( FDR ) was shown to have nearly wild type ability to bind native human Fas ligand and was expressed predominantly at the plasma membrane . 0.66841538^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.64122235
Fas ligand triggers cell death after interaction with its receptor Fas . 0.64122235^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.60327846
DAXX and other death receptor associated proteins , which have been reported to bind directly or indirectly to Fas , such as receptor interacting protein ( RIP ) and RIP associated ICH 1 / CED 3 homologous protein with a death domain ( RAIDD ) , were shown to be dispensable for Fas ligand induced apoptosis . . 0.60327846^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :1.1698466
The transmembrane receptor Fas / APO 1 , together with its protein binding partner ( Fas ligand ) , is a key regulator of programmed cell death and induces apoptosis when it binds Fas ligand ( FasL ) or soluble Fas ligand ( sFasL ) . 1.1698466^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.78274117
The specific interaction of Fas with its cognate ligand , Fas ligand ( FasL ) , elicits the activation of a death inducing caspase ( cysteine aspartic acid proteases ) cascade , occurring in a transcription independent manner . 0.78274117^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.75586069
OBJECTIVE : Interactions of the FAS with FAS ligand have been proposed as a major regulatory mechanism of immune homeostasis . 0.75586069^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.62903181
Interaction of Fas with Fas ligand ( FasL ) is known to play a role in peripheral tolerance mediated by clonal deletion of Ag specific T cells . 0.62903181^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.63527908
OBJECTIVE : The Fas ( CD 95 ) interaction with its receptor Fas ligand ( FasL ) is one of the main mechanisms of cell apoptosis . 0.63527908^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.60943317
Activated CD8+ T cells lyse their targets by perforin dependent granule exocytosis and by inducing apoptosis mediated by CD 95 ( also known as Fas or APO 1 ) with its ligand ( CD95L ) . 0.60943317^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.68617856
Apoptosis may be triggered , in a variety of tissues , by interaction of the cell surface molecule CD 95 with its specific ligand , CD95L . 0.68617856^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :1.4330595
The interactions of CD 95 antigen ( Fas ) with its ligand ( CD95L ) and of tumor necrosis factor ( TNF ) alpha with its receptor ( TNF R 1 ) lead to apoptotic cell death . 1.4330595^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.68563968
In turn , CD95L binds to the Fas receptor ( CD 95 ) and rapidly induces apoptosis in cycling cells . 0.68563968^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :1.064415
The interaction of CD 95 with its ligand CD95L is important for negative selection of B cells during the germinal center ( GC ) reaction . 1.064415^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.67920912
The interaction of CD 95 with its ligand , CD95L ( FasL ) , induces apoptosis and thus the source of the death inducing ligand is critical for understanding the pathomechanism of liver damage involving the CD 95 system . 0.67920912^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.70988886
Hyperosmolarity and CD 95 ligand ( CD95L ) induced interactions between CD 95 ( Fas / APO 1 ) and the epidermal growth factor receptor ( EGFR ) involve EGFR catalyzed CD 95 tyrosine phosphorylation . 0.70988886^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :1.0955005
BACKGROUND : The surface molecule named Fas / CD95 , which is expressed on activated lymphocytes , can trigger cell death following interaction with its ligand ( Fas L ) . 1.0955005^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.62150473
FasL binds to Fas , which results in target cell apoptosis . 0.62150473^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :1.0577154
In this study , we have investigated the roles of Fas interaction with its ligand ( FasL ) and of accessory cells in the CD4XL model of T cell apoptosis mediated by the anti CD 4 mAb Leu3a or HIV 1 envelope protein g 120 . 1.0577154^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.62150473
FasL binds to Fas , which results in target cell apoptosis . 0.62150473^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.57350415
The death inducing receptor Fas is activated when cross linked by the type 2 membrane protein Fas ligand ( FasL ) . 0.57350415^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.52042571
FasL binds to Fas on target cells and induces apoptosis . 0.52042571^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.76911876
However , soluble FasL retained its capacity to interact with Fas , and restoration of its cytotoxic activity was achieved both in vitro and in vivo with the addition of cross linking antibodies . 0.76911876^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.60602971
When FasL interacts with its Fas , the Fas bearing cell undergoes apoptosis . 0.60602971^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.68280247
The engagement of T cells bearing FasL with Fas expressing tubular epithelial cells ( TECs ) induced TEC apoptosis in vitro . 0.68280247^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.56053496
Finally , recombinant human FasL induced apoptosis in Fas expressing porcine EC cells , demonstrating that human FasL interacted with and activated Fas on porcine EC cells . 0.56053496^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.52519785
BACKGROUND : In the acute rejection of allografts , the interaction between Fas ( CD 95 ) and its ligand ( FasL ; CD95L ) has been shown to be involved in mediating apoptotic cell death . 0.52519785^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.513209
Our data indicate that ET 18 OCH ( 3 ) induces apoptosis via Fas after the ether lipid is inside the cell , and this Fas activation is independent of the interaction of Fas with its natural ligand FasL . 0.513209^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.52839788
Activation induced cell death ( AICD ) is a mechanism of peripheral T cell tolerance that depends upon an interaction between Fas and Fas ligand ( FasL ) . 0.52839788^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.56927073
Binding of FasL to Fas was blocked with two reagents that bind to the extracellular domain of FasL : an anti FasL antibody and Fas : Fc , a chimeric protein consisting of the Fc portion of human immunoglobulin G and the extracellular domain of human Fas . 0.56927073^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.77935889
The subsequent interaction of FasL with Fas ( CD 95 ) displayed on neighbouring cells , including HIV 1 specific cytotoxic T lymphocytes , may lead to bystander cell killing and thus forms an important mechanism of immune evasion . 0.77935889^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.5267427
Activation induced cell death ( AICD ) is a well known mechanism of peripheral T cell tolerance that depends upon an interaction between Fas and Fas ligand ( FasL ) . 0.5267427^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.71866602
Interaction between Fas and Fas ligand ( FasL ) induces apoptotic cell death of Fas positive cells . 0.71866602^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.62664286
It is well documented that T cells may undergo apoptosis due to interactions between Fas and Fas ligand ( FasL ) . 0.62664286^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.6935195
Indeed , tumor cells expressing FasL can efficiently interact with dendritic cells ( DCs ) and this interaction requires the expression of membrane bound FasL on tumors and Fas on DCs . 0.6935195^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.88082545
Moreover , mutant FasL transduced to donor tissues was found to exert its effects by binding to host , rather than donor Fas molecules , since corneal grafts with mutant FasL survived as long as those without transfection only when host animals , but not donor animals , lacked Fas molecules . 0.88082545^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.57976046
For a better understanding of the biological features of astrocytic tumors , we investigated apoptosis and its pathway , especially in the interaction between Fas and Fas ligand ( FasL ) . 2 . 0.57976046^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.59910658
The interaction between Fas and Fas ligand ( FasL ) is involved in the apoptotic death of a number of cells including lymphocytes . 0.59910658^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.72518834
Previous studies have shown that keratinocyte apoptosis in TEN and SJS was induced by a suicidal interaction between Fas and Fas ligand ( FasL ) , which are both expressed by keratinocytes . 0.72518834^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.5409145
Protection is not solely dependent on local interactions between Fas and FasL , but rather requires induction of a paradoxical inflammatory response that not only destroys Fas resistant tumors , but also recruits motile , activated , Fas bearing T cells that are Fas sensitive . 0.5409145^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Potentiation of CD95L induced apoptosis of human malignant glioma cells by topotecan involves inhibition of RNA synthesis but not changes in CD 95 or CD95L protein expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ionizing radiation alters Fas antigen ligand at the cell surface and on exfoliated plasma membrane derived vesicles : implications for apoptosis and intercellular signaling . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recent evidence indicates that this regulatory function operates through deletion of activated T and B lymphocytes by CD4+ T cells expressing the Fas ligand . ^^^ Failure to delete macrophages that constitutively present self antigens may contribute to the expression of autoimmunity in mice deficient in FasR ( lpr ) or Fas ligand ( gld ) . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas is a type 1 membrane protein and its activation by binding of the Fas ligand or an agonistic anti Fas antibody induces apoptosis in Fas bearing cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Characterization of the non functional Fas ligand of gld mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recently , a granule independent cytolytic mechanism involving the interaction of the apoptosis triggering Fas antigen ( CD 95 ) with Fas ligand ( FasL ) has been revealed in T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Metalloproteinase mediated release of human Fas ligand . ^^^ Fas ligand ( FasL ) is a type 2 integral membrane protein homologous with tumor necrosis factor ( TNF ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Inflammatory cells entering the anterior chamber of the eye in response to viral infection underwent apoptosis that was dependent on Fas ( CD 95 ) Fas ligand ( FasL ) and produced no tissue damage . ^^^ Fas ligand induced apoptosis as a mechanism of immune privilege . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Molecular cloning and expression of the Fas ligand , a novel member of the tumor necrosis factor family . ^^^ Using a soluble form of mouse Fas , prepared by fusion with human immunoglobulin Fc , Fas ligand was detected on the cell surface of a cytotoxic T cell hybridoma , PC 60 d10S . ^^^ A cell population that highly expresses Fas ligand was sorted using a fluorescence activated cell sorter , and its cDNA was isolated from the sorted cells by expression cloning . ^^^ The amino acid sequence indicated that Fas ligand is a type 2 transmembrane protein that belongs to the TNF family . ^^^ The recombinant Fas ligand expressed in COS cells induced apoptosis in Fas expressing target cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Correction of gld autoimmunity by co infusion of normal bone marrow suggests that gld is a mutation of the Fas ligand gene . lpr and gld mice develop phenotypically indistinguishable systemic autoimmune diseases and marked lymphadenopathy dominated by CD 4 CD8 T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Purification and characterization of the Fas ligand that induces apoptosis . ^^^ These results indicated that the 40 kD membrane glycoprotein expressed on PC 60 d10S cells is the Fas ligand that induces the apoptotic signal by binding to Fas . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Generalized lymphoproliferative disease in mice , caused by a point mutation in the Fas ligand . ^^^ Fas ligand ( FasL ) is a tumor necrosis factor ( TNF ) related type 2 membrane protein and binds to Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand and Fas : a death factor and its receptor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Anti CD 3 activated but not resting BK 1 expressed Fas ligand as detected by binding of a soluble Fas Ig fusion protein , and the BK 1 mediated cytotoxicity was blocked by the addition of Fas Ig , implicating the inducible Fas ligand in the BK 1 cytotoxicity . ^^^ Interestingly , CD4+ T cells prepared from gld / gld mice did not mediate the Fas mediated cytotoxicity , indicating defective expression of functional Fas ligand in gld mice . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
On the other hand , NK1 . 1+ effector thymocytes from gld mice that carry a point mutation in Fas ligand did not kill thymocyte targets from normal mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas ligand has been cloned , and is a member of the tumor necrosis factor family . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
T cell receptor induced Fas ligand expression in cytotoxic T lymphocyte clones is blocked by protein tyrosine kinase inhibitors and cyclosporin A . ^^^ We demonstrate that both the TcR+ and TcR clones were able to express the Fas ligand after stimulation with phorbol 12 myristate 13 acetate ( PMA ) / ionomycin , and that TcR engagement of the KB5 . ^^^ In addition , using inhibitors we investigated the signal transduction pathway ( s ) involved in the induction of Fas based cytotoxicity and expression of the Fas ligand mRNA in the CTL clones . ^^^ The involvement of src like protein tyrosine kinases ( PTK ) in Fas ligand induction through TcR engagement , was strongly suggested by inhibition with the src like PTK inhibitor herbimycin A . ^^^ Inhibition of Fas ligand induction by genistein , a more general TPK inhibitor , even upon stimulation by PMA plus ionomycin , suggested the possible involvement of PTK activities downstream of protein kinase C ( PKC ) in Fas ligand induction in CTL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In animal models of autoimmune diseases , mutations of genes involved in apoptosis including Fas , Fas ligand , and the hematopoietic cell phosphatase gene have been identified . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
An additional important feature in gld mice is a defect in expression of Fas ligand . ^^^ These findings also suggest that the Fas ligand is selectively expressed on T cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It is probable that the mechanism by which normal Thy 1+ cells mediate the suppression is Fas ligand dependent . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Evidence for an intrinsic and extrinsic role for Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The human 10 linked immunodeficiency , hyper IgM syndrome , is the result of mutations in the CD 40 ligand gene , and the Fas and Fas ligand genes are mutated in two mouse strains , lpr and gld , that develop autoimmune disease . ^^^ These findings , together with other evidence , point to key roles of CD40 / CD40 ligand interactions in immune activation , particularly in T dependent B cell responses , and of Fas / Fas ligand in apoptosis and peripheral tolerance . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Massive upregulation of the Fas ligand in lpr and gld mice : implications for Fas regulation and the graft versus host disease like wasting syndrome . ^^^ Since the Fas ligand ( FasL ) has recently been shown to be partly responsible for T cell mediated cytotoxicity , lymph node cells from lpr and gld mice were examined for the expression of FasL mRNA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand mediates activation induced cell death in human T lymphocytes . ^^^ Ligation of Fas on activated T cells by either Fas antibodies or recombinant human Fas ligand ( Fas L ) also results in cytolysis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The gene gld , which causes an autoimmune syndrome phenotypically identical to that caused by lpr , encodes a mutant Fas ligand . ^^^ The persistence with age of low levels of B cell apoptosis in lpr and gld mice presumably reflects deficient Fas / Fas ligand interactions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Differential ability of Th 1 and Th 2 T cells to express Fas ligand and to undergo activation induced cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Constitutive activation of the Fas ligand gene in mouse lymphoproliferative disorders . ^^^ The lpr mice have a defect in a cell surface receptor , Fas , that mediates apoptosis , while gld mice have a mutation in the Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Induction of Fas based cytotoxicity was Ca ( 2+ ) dependent , while its execution was not ; induction was sensitive to macromolecular synthesis inhibitors , in line with a demonstrable increase of the Fas ligand ( Fas L ) message . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis regulated by a death factor and its receptor : Fas ligand and Fas . ^^^ Our recent studies on the Fas ligand and Fas indicate that they work respectively as a death factor and its receptor and suggest that , in some cases , cell death or apoptosis is regulated by cytokines and their receptors . ^^^ Here , 1 present the summary of the Fas / Fas ligand system which has been studied in my laboratory over the past 5 years , and 1 will discuss its physiological roles . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
One of these involves Fas at the target cell surface and a Fas ligand at the effector cell surface . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Those mAb that inhibited apoptosis of target cells mediated by the CH 11 mAb also blocked lysis of target cells mediated by cells expressing Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of Fas ligand on natural killer ( NK ) cells and Fas mediated cytotoxicity by NK cells was investigated . ^^^ Fas ligand mRNA was expressed in freshly isolated NK cells but not in T cells . ^^^ Furthermore , the Fas ligand was detected on the cell surface of NK cells by staining with soluble Fas molecule . ^^^ These results demonstrated that NK cells express Fas ligand and possess the capability of killing target cells expressing Fas antigen on their surface . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand : a death factor and its receptor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL ) , a cell surface molecule belonging to the tumor necrosis factor family , binds to its receptor Fas , thus inducing apoptosis of Fas bearing cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand : lpr and gld mutations . ^^^ Fas ligand ( FasL ) is a death factor that binds to its receptor , Fas , and induces apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Proteins encoded by the fas and fas ligand ( fasL ) genes are involved in apoptotic cell death in lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of the functional soluble form of human fas ligand in activated lymphocytes . ^^^ Fas ligand ( FasL ) is a 40 kDa type 2 membrane protein expressed in cytotoxic T cells upon activation that belongs to the tumor necrosis factor ( TNF ) family . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and activation induced Fas ligand mediate apoptosis of T cell hybridomas : inhibition of Fas ligand expression by retinoic acid and glucocorticoids . ^^^ Unlike 2B4 . 11 cells , VD 1 cells were not killed by Fas ligand ( FasL ) bearing effector cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Binding of Fas ligand or agonistic anti Fas antibody to Fas kills the cells by apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
For CD8+ cytotoxic T lymphocytes , the two primary cytotoxic pathways are mediated by the Fas ligand and perforin . ^^^ The dichotomy between the two killing pathways is mirrored in the dichotomy between their biological roles : the primary function of the Fas ligand is the control of normal cell renewal by inducing programmed cell death of actively proliferating cells via the Fas pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Murine CD4+ Th 1 clones require de novo synthesis of proteins to express a cytotoxicity that is mediated by de novo synthesized Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Taken together with prior studies demonstrating a role for Fas / APO 1 and Fas ligand , respectively , in tumor target cell killing by cytotoxic T lymphocytes , production of soluble Fas / APO 1 might have significant implications in malignant disease pathogenesis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Fas ligand interactions serve as a signaling pathway for apoptosis ( 1 3 ) , an important regulatory mechanism in the development and function of the immune system ( 4 9 ) . ^^^ We observed that Fas transcripts are constitutively expressed in syngeneic and allogeneic murine cardiac transplants , while Fas ligand ( FasL ) is up regulated only in rejecting allografts . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Requirement of p56lck in T cell receptor / CD3 mediated apoptosis and Fas ligand induction in Jurkat cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
AID of peripheral T cells requires the expression of functional Fas and Fas ligand by the T cell population . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recently , activation , T cell hybridomas rapidly express the Fas / CD95 receptor and its ligand , Fas ligand ( FasL ) , which interact to transduce the death signal in the activated cell . ^^^ We report here that 9 cis RA inhibits T cell receptor mediated apoptosis in T cell hybridomas by blocking the expression of Fas ligand following activation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Human Fas / Apo 1 is a cell surface protein that mediates apoptosis upon ligation with Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Since this occurred in an athymic recipient , the correction of the gld syndrome did not require wild stem cell differentiation within a thymic environment , but should only depend on a sufficient Fas ligand supply by normal wild cells . ^^^ Since the gld cells could proliferate in the nubg environment , the nubg environment could not provide sufficient Fas ligand to regulate the gld cell proliferation . ^^^ Thus , the nubg B cells might lack Fas ligand expression , or express it but to a lower extent that T cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptotic death of lymphocytes in murine acquired immunodeficiency syndrome : involvement of Fas Fas ligand interaction . ^^^ In contrast , mice carrying mutations in either Fas or Fas ligand exhibited accelerated progression of the disease upon infection with MAIDS virus . ^^^ These results suggest the involvement of Fas Fas ligand system in the pathogenesis of MAIDS . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Down modulation of CD4+ T helper type 2 and type 0 cells by T helper type 1 cells via Fas / Fas ligand interaction . ^^^ A reciprocal relationship in Fas and Fas ligand expression was observed in CD4+ T helper ( Th ) 1 and Th 2 type clones , and Fas mRNA was predominantly detected in Th 2 clones , whereas Fas ligand mRNA was principally found in Th 1 clones . ^^^ The two Th 0 clones tested expressed both Fas and Fas ligand , but only one exhibited cytolytic activity , whereas both were sensitive to CD 4 mediated lysis . ^^^ A functional consequence of the inverse Fas Fas ligand expression pattern was that Th 2 and Th 0 cells were sensitive to lysis by both Th 1 CD4+ CTL and a CD8+ CTL clone in a Fas dependent manner . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although Fas and Fas ligand ( FasL ) interactions play a major role in the elimination of self reactive T cells in the periphery , inhibition of Fas mediated killing by Bcl 2 has not been consistently observed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
C3H gld / gld `` fas ligand mutant mice ' ' challenged with SEB / D GalNH 2 were comparable to C57Bl / 6 . ^^^ MRL lpr / lpr and MRL lpr / lpr mice , suggesting that reciprocal mutations in either fas or fas ligand increases susceptibility to bacterial superantigens ( SAGs ) . ^^^ These data indicate that SAG induced septic shock is dependent on interactions with the TCR and MHC class 2 Ags , and they also suggest a critical role for a functional fas and / or fas ligand in resistance to SAG induced septic shock . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The recessive mouse mutations lpr and gld create deficiencies in an interacting pair of cell surface molecules , CD 95 ( Fas / APO 1 ) and Fas ligand ( FasL ) , respectively , resulting in autoantibody production resembling human systemic lupus erythematosus . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of other cytolytic mediators , present either within the granules ( granzymes A and B ) or elsewhere ( Fas ligand ) , appeared to be unperturbed , as investigated using the reverse transcription PCR technique . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Efficient inhibition of activation induced Fas ligand up regulation and T cell apoptosis by retinoids requires occupancy of both retinoid 10 receptors and retinoic acid receptors . ^^^ Activation induced T cell hybridoma death is mediated via the engagement of Fas by activation up regulated Fas ligand , and RA prevents this type of apoptosis by inhibiting the induction of Fas ligand expression . ^^^ The same hierarchy of efficacy was found for activation induced Fas ligand expression . ^^^ These data demonstrate that binding of both RARs and RXRs is required for efficient inhibition of activation induced Fas ligand upregulation and T cell apoptosis by retinoic acid . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recent advances include definition of key molecules driving the cell death programme , including Fas and Fas ligand in the plasma membrane , and cytoplasmic proteases such as interleukin 1 beta converting enzyme . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of the Fas ligand in cells of T cell lineage . ^^^ Fas ligand ( FasL ) is a membrane type cytokine belonging to the TNF family , and induces apoptosis through its cell surface receptor , Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Both result from defective apoptosis , the targets of the lpr and gld mutations being the genes for , respectively , an apoptosis signalling receptor [ the Fas antigen receptor ( FasR ) ] and its counter receptor [ the Fas ligand ( FasL ) ] . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Human Fas ligand : gene structure , chromosomal location and species specificity . ^^^ Fas ligand ( FasL ) is a 40 kDa type 2 membrane protein belonging to the tumor necrosis factor family , which induces apoptosis by binding to its receptor , Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The mouse Fas ligand gene is mutated in gld mice and is part of a TNF family gene cluster . ^^^ The gene for the mouse Fas ligand was cloned and its chromosomal position determined . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Role of Fas ligand in apoptosis induced by hepatitis C virus infection . ^^^ To investigate the role that Fas ligand plays in the apoptosis of hepatocytes induced by hepatitis C virus infection , we isolated a cDNA clone for human Fas ligand and examined the expression of Fas ligand in liver infiltrating mononuclear cells obtained from patients with chronic hepatitis C . ^^^ The amino acid sequence of human Fas ligand showed 76 % and 77 % identity with those of rat and mouse Fas ligand , respectively . ^^^ When the expression of Fas ligand transcripts was tested by reverse transcription polymerase chain reaction , the amplified signal was detected in liver infiltrating mononuclear cells and peripheral blood mononuclear cells , whereas only a weak signal or none at all was detected in liver tissues . ^^^ These findings suggest that the Fas ligand Fas antigen system may play an important role in liver cell injury by hepatitis C virus infection . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Based on the linkage between the lpr locus and Fas Ag expression , we propose that the failure of lpr mice to express Fas results in overproduction of Fas ligand , whereas gld mice fail to make either the Fas ligand or a functionally related protein , presumably belonging to the TNF family . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas , a member of the tumor necrosis factor receptor family , can induce apoptosis when activated by Fas ligand binding or anti Fas antibody crosslinking . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Two signaling pathways can lead to Fas ligand expression in CD8+ cytotoxic T lymphocyte clones . ^^^ C20 ) could be induced to express the Fas ligand ( FasL ) by either T cell receptor ( TCR ) engagement or phorbol 12 myristate 13 acetate ( PMA ) / ionomycin stimulation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cytotoxic T cells ( CTL ) induce cell death of their target cells either by the surface interaction between Fas ligand and Fas or by the release of perforin and granzymes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Functional expression of Fas and Fas ligand on human gut lamina propria T lymphocytes . ^^^ A discrete fraction of freshly isolated T LPL also constitutively expressed Fas ligand ( FasL ) , perhaps as a result of recent in vivo activation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The sphingomyelin pathway , initiated by hydrolysis of the phospholipid sphingomyelin in the cell membrane to generate the second messenger ceramide , is thought to mediate apoptosis in response to tumour necrosis factor ( TNF ) alpha , to Fas ligand and to 10 rays . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The disruption of the Fas receptor or Fas ligand by the lpr or gld mutations , respectively , results in severe autoimmune and lymphoproliferative disease due to the failure of Fas mediated deletion of self reactive lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL , Apo 1L ) is a member of the tumor necrosis factor protein family and binding to its receptor ( Fas , Apo 1 , CD 95 ) triggers cell death through apoptosis . ^^^ Activated B cells express functional Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand in embryos and adult mice : ligand expression in several immune privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis was associated with enhanced expression of Fas and Fas ligand in unstimulated cell populations , and partially inhibited by soluble anti Fas mAb . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fc receptor induced expression of Fas ligand on activated NK cells facilitates cell mediated cytotoxicity and subsequent autocrine NK cell apoptosis . ^^^ We demonstrate in this study that FcR stimulation of activated human NK cells not only induces granule exocytosis , but also subsequently results in the transcriptional up regulation of Fas ligand . ^^^ We demonstrate in this work that the interaction of Fas ligand on the FcR stimulated NK cells with their Fas receptors can result in apoptosis of the NK cells . ^^^ These results suggest that the FcR induced expression of Fas ligand on activated NK cells can critically influence the capacity of these cells to mediate paracrine and autocrine cell death . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand in human serum . ^^^ The Fas ligand ( FasL ) , a member of the tumor necrosis factor family , induces apoptosis in Fas bearing cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Several articles have been devoted to study of the molecular mechanisms responsible for APO 1 / CD95 ( Fas ) is a cell surface protein that can mediate apoptosis in lymphoid cells , and Fas ligand was recently identified in a cytotoxic T cell line . ^^^ To clarify the involvement of the Fas Fas ligand system in granulosa cell apoptosis , we investigated the expression of Fas and Fas ligand at an individual cell level . ^^^ For this purpose , we raised specific polyclonal antibodies against Fas and Fas ligand . ^^^ On the other hand , the anti Fas ligand antibody ( anti P 5 ) detected a specific 31 kDa band on a Western blot of the oocytes lysate , and the staining with the serum was localized to oocytes in most of developing follicles . ^^^ Colocalization of Fas and Fas ligand in certain follicles intimately correlated with granulosa cell apoptosis , which was revealed by terminal deoxynucleotidyl transferase mediated deoxy UTP biotin nick end labeling staining of DNA strand breaks . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Binding of Fas ligand or an agonistic anti Fas antibody induces apoptosis in Fas bearing cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas , also called APO 1 , belongs to the tumor necrosis factor / nerve growth factor receptor family and transmits an apoptotic signal within the cell by binding to the Fas ligand . ^^^ Fas , also called APO 1 , belongs to the tumor necrosis factor / nerve growth factor receptor family and transmits an apoptotic signal within the cell by binding to the Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( CD 95 ) / Fas ligand interactions regulate antigen specific , major histocompatibility complex restricted T / B cell proliferative responses . ^^^ Fas ( CD 95 ) / Fas ligand interactions regulate antigen specific , major histocompatibility complex restricted T / B cell proliferative responses . ^^^ The effect of Fas ligand ( FasL ) cytotoxicity on T / B collaboration was examined in vitro using cloned T helper 1 cells and antigen pulsed , activated B cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In normal activated T cells , CD 3 mediated apoptosis is prevented by reagents that block the Fas / Fas ligand interaction , namely soluble M 3 ( an antagonistic anti Fas mAb ) and soluble human Fas . ^^^ Fc , a fusion protein able to bind released Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Noteworthy findings are that mRNA of Fas ligand was expressed in MC . ^^^ Taken together , MC appears to control the proliferation by regulating Fas system mediated apoptosis , at least in part , through an autoregulatory mechanism with Fas Ag Fas ligand expressed on their own MC . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cloned murine CTL activated via the TCR or by PMA and ionomycin up regulate surface Fas ligand and show an increased ability to kill non Ag specific Fas+ target cells . ^^^ Up regulation of lytic function is accompanied by up regulation of Fas ligand on the CTL surface , which can be blocked by protein synthesis inhibitors . ^^^ When up regulation of Fas lytic function was induced by PMA and ionomycin , EGTA blocked both activation of lytic function and expression of Fas ligand detected by FACS analysis . ^^^ However , when up regulation was induced by specific Ag , EGTA blocked activation of lytic function , but not up regulation of Fas ligand . ^^^ Moreover , EL 4 cells have very high levels of surface Fas ligand , although they are not cytotoxic . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cytotoxicity effector transcripts were largely intact in CTLA 4 Ig + bone marrow treated recipients as they showed no decrease in intragraft granzyme , perforin , Fas , or Fas ligand transcripts during thr first 8 days after transplant . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The inhibition of T cell receptor induced Fas ligand upregulation by cyclosporine and FK 506 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , activated T lymphocytes from the fyn deficient mice are less sensitive to killing by both anti Fas antibody and Fas ligand cytotoxic T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Peripheral T cells undergoing superantigen induced apoptosis in vivo express B 220 and upregulate Fas and Fas ligand . ^^^ We show that dying , SEB reactive T cells express high levels of Fas and Fas ligand ( Fas L ) , which are implicated in apoptotic cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft versus host disease . ^^^ Here , we show that acute lethal GVHD , induced by the transfer of splenocytes from C57BL / 6 mice into sensitive BALB / c recipients , is dependent on both perforin and Fas ligand ( FasL ) mediated lytic pathways . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Since the deletion involves the first cysteine rich motif believed to be necessary for binding to the Fas ligand , the T Fas protein may lack the ability to induce apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In one case , the lack of functional Fas receptors was associated with failure of Fas mRNA and protein expression , and in another , expression of a soluble form of the Fas molecule that may have antagonized normal signaling of Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis of nur77 / N10 transgenic thymocytes involves the Fas / Fas ligand pathway . ^^^ Moreover , nur77 / N10 transgenic thymocytes show increased expression of Fas ligand ( FasL ) , while the levels of the Fas receptor ( Fas ) are not increased . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast to this pleiotropic effect , the anti TNF alpha ribozyme treatment did not affect the heterogenous expression of Fas ligand by peritoneal cells , indicating the specificity of the treatment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We found that all soluble proteins block the apoptosis induced by either an agonistic Ab or , more importantly , by the natural Fas ligand in Fas positive sensitive cell lines . interestingly , this functional property can be assigned to the first 49 amino acids of the mature protein that is the only region shared by the five soluble Fas molecules . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We report here that CD4+ and CD8+ T cells from HIV 1 infected persons are sensitive to Fas ( CD95 / APO 1 ) mediated death induced either by an agonistic anti Fas antibody or by the physiologic soluble Fas ligand , although showing no sensitivity to tumor necrosis factor alpha induced death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ceramide is an important regulatory participant of programmed cell death ( apoptosis ) induced by tumour necrosis factor ( TNF ) alpha and Fas ligand , members of the TNF superfamily . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immune response and myoblasts that express Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the presence of cMAbs , apoptosis is the primary mechanism of NK cell mediated killing in monolayers of SCCHN targets , which were found to express receptors for tumor necrosis factor and fas ligand . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas ligand binds to its receptor , Fas , and induces apoptosis in Fas bearing cells . ^^^ The Fas ligand or an agonistic anti Fas antibody stimulated proliferation of the FDC P 1 transformants expressing a chimera consisting of the Fas extracellular and G CSFR cytoplasmic regions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Viable motheaten ( me ( 5 ) / me ( 5 ) ) mice exhibited increased T cell proliferation and defective activation induced apoptosis of Fas+ T cells in the lymph node , which was not ascribed to defective Fas ligand function . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Thus , the induced apoptosis of resting B cells and the NZB defect are likely not related to either Fas or Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A subclass of dendritic cells kills CD 4 T cells via Fas / Fas ligand induced apoptosis . ^^^ By using various mixtures of T cells and DC from Fas mutant lpr / lpr mice and Fas ligand ( FasL ) mutant gld / gld mice , we show this death is due to interaction of Fas on activated T cells with FasL on CD8+ DC . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In vivo analysis revealed increased activation and apoptosis of T cells associated with increased expression of Fas and Fas ligand in LN of deltaNur 77 Db / HY TCR alpha / beta double male mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The second cytolytic effector system relies on the interaction of the Fas ligand ( Fasl ) on the effector cell with its receptor ( Fas ) on the target cell , leading to apoptotic cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Mutation in genes encoding Fas ( Ipr ) and the Fas ligand ( gld ) contribute to the development of an autoimmune syndrome similar to systemic lupus erythematosus in mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , activated Th 1 clones , which produce IFN gamma and express both CD40L and Fas ligand ( FasL ) on their cell surface , often induce B cell apoptotic cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
HIV 1 upregulates Fas ligand expression in CD4+ T cells in vitro and in vivo : association with Fas mediated apoptosis and modulation by aurintricarboxylic acid . ^^^ Our ability to downregulate Fas ligand message and suppress HIV mediated apoptosis with aurintricarboxylic acid , a clinically used protease inhibitor with known activity against programmed cell death in other systems , may open up a new area of therapy for HIV infection . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Effects of antigen presentation on superantigen induced apoptosis mediated by Fas / Fas ligand interactions in human T cells . ^^^ Using both a bioassay and messenger RNA analysis we were able to demonstrate that stimulation of these T cells with superantigen resulted in the induction of Fas ligand expression on the T cells and furthermore , the ability of these cells to induce apoptosis was inhibited by the addition of blocking Fas antibodies as well as a Fas Fc fusion protein . ^^^ These data demonstrate that stimulation of T cells with staphylococcal enterotoxin B induces expression of Fas ligand resulting in T cell apoptosis ; however , the final outcome of proliferation or apoptosis is determined by the presence of APC . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas Fas ligand system and other modulators of apoptosis in the cornea . ^^^ The authors examined the expression of the apoptosis related modulators , Fas ( receptor ) , Fas ligand , Bax , Bcl 2 , Bcl XL , and interleukin 1 beta converting enzyme ( ICE ) in corneal cells as candidate mediators of this response and tested the effect of Fas receptor stimulating antibody on corneal stromal fibroblast cells in vitro . ^^^ METHODS : Reverse transcription polymerase chain reaction was used to detect FAS , FAS ligand , Bax , Bcl 2 , Bcl XL , and ICE mRNA expression in primary cultures of human corneal epithelial , stromal fibroblast , and endothelial cells . ^^^ Immunohistochemistry was applied to detect Fas and Fas ligand proteins in fresh frozen sections of normal human cornea . ^^^ RESULTS : FAS , Fas ligand , Bax , Bcl 2 , Bcl XL , and ICE mRNAs are expressed in all three major cell types of the cornea . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Selective activation of Fas / Fas ligand mediated cytotoxicity by a self peptide . ^^^ This killing was shown to be entirely Fas / Fas ligand mediated by blocking with anti Fas antibody and Fas Fc chimeric molecules . ^^^ However , when the level of self antigen is increased ( by using synthetic peptide loading ) CD8+ T cells may respond by proliferation , IFN gamma secretion , Fas ligand upregulation , and Fas mediated cytolysis but are still unable to respond by perforin mediated cytolysis or granzyme release . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , HM1R induced apoptosis is inhibited by blocking Fas ligand / Fas interaction with an antagonist anti Fas Ab , and Fas ligand mRNA and protein are expressed in J HM 1 2 . 2 cells stimulated through the HM1R . ^^^ Therefore , protein tyrosine kinase activation is not an absolute requirement for receptor controlled Fas ligand expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas transduces a signal for apoptosis in sensitive cells after binding by specific antibodies or following contact with natural Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cytotoxic function of CD4+ Th 1 cells is mediated by Fas ( CD 95 , APO 1 ) and its ligand ( Fas ligand ) . ^^^ These results establish CD4+ T cells and the Fas Fas ligand system as important immune regulators of Burkitt ' s lymphoma B cells and indicate that the susceptibility of tumor cells to Fas mediated death signals can be modulated by specific activation events at the cell surface . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These findings indicate that MV 1 T cells killed target cells via a Fas ligand ( FasL ) / Fas pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( CD 95 ) receptor and Fas ligand expression in bone marrow cells from patients with myelodysplastic syndrome . ^^^ Fas ( CD 95 ) receptor and Fas ligand expression in bone marrow cells from patients with myelodysplastic syndrome . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Studies with perforin deficient mice have demonstrated that two independent mechanisms account for T cell mediated cytotoxicity : A main pathway is mediated by the secretion of the pore forming protein perforin by the cytotoxic T cell , whereas an alternative nonsecretory pathway relies on the interaction of the Fas ligand that is upregulated during T cell activation with the apoptosis inducing Fas molecule on the target cell . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Molecular biology of Fas antigen Fas ligand system ] . ^^^ The binding of agonistic anti Fas antibody or Fas ligand to Fas antigen induces apoptosis . ^^^ Fas ligand is a type 2 membrane protein of 40 kDa that belongs to the TNF family . ^^^ Fas ligand is predominantly expressed in activated T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas mediates apoptosis by its crosslinking with Fas ligand or some monoclonal anti Fas antibodies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Metalloproteinase mediated release of human fas ligand ] . ^^^ Molecular cloning of Fas ligand ( FasL ) revealed that it is a type 2 integral membrane protein homologous to TNF . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Abnormal Fas and Fas ligand expression of lymphocytes in patients with SLE ] . ^^^ Fas and Fas ligand ( FasL ) have been assigned a pivotal role for establishment and maintenance of peripheral tolerance of immune system , and mice having defects in Fas / FasL genes develop diseases resembling human systemic lupus erythematosus ( SLE ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas / Fas ligand and proto oncogenes in rheumatoid synovial tissues ] . ^^^ Expression of Fas antigen and Fas ligand ( L ) were observed in synovial tissue from rheumatoid arthritis ( RA ) patients , whereas in only a few cells expressed these molecule osteoarthritis synovial tissue . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Involvement of Fas and Fas ligand in case of human fulminant hepatitis ] . ^^^ Since it has been reported that administration of anti Fas monoclonal antibody into mouse peritoneal cavity causes fulminant hepatitis ( FH ) in vivo , the Fas Fas ligand system is thought to play important roles in massive hepatocytes death in FH . ^^^ In murine system , there are several reports which showed Fas Fas ligand system involved in FH . ^^^ In human , the expression of Fas antigen was markedly increased on the cell surface of the hepatocytes and Fas ligand was expressed on the hepatic infiltrated lymphocytes . ^^^ It is suggested that the Fas Fas ligand system also play important roles in human FH . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas and Fas ligand in epithelium of ulcerative colitis ] . ^^^ The apoptotic cells recognized by their typical morphology and the presence of DNA breaks are also accompanied by Fas and Fas ligand . ^^^ It is thought when Fas ligand bound the Fas , the cells bearing Fas will enter a path of apoptosis . ^^^ These findings suggest that unscheduled apoptosis in the UC crypts takes place and the apoptosis is mediated by a auto or paracrine Fas / Fas ligand interaction . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In an attempt to determine whether the Fas Fas ligand mediated apoptosis occurs in the pathologic process of human myopathies , we examined the expression of Fas antigen , Fas ligand mRNA , and chromosomal DNA fragmentation in the muscle cells of several human muscle disorders . ^^^ However , there was no evidence of an apoptotic process , nor Fas ligand synthesis in the diseased muscle tissue . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Binding of the Fas ligand ( FasL ) to Fas induces apoptosis in Fas bearing cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression of TILs should be determined in future . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Since cytotoxic T lymphocytes ( CTL ) express Fas ligand and kill Fas+ target cells , a significant potentiation of tumor cell killing will be achieved following sensitization of tumor cells to Fas signaling by subtoxic concentrations of CDDP . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here , we show that PBT cells , but not Mo , express functional Fas ligand upon treatment with PMA . ^^^ These results strongly suggest involvement of Fas Fas ligand interaction in the death of PBT cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Perforin , Fas ligand , and tumor necrosis factor are the major cytotoxic molecules used by lymphokine activated killer cells . ^^^ LAK cells are also capable of Fas ligand mediated cytotoxicity . ^^^ LAK cells generated from mice deficient in both perforin and Fas ligand ( PKO / gld ) were not cytolytic in short term cytotoxicity assays , demonstrating that perforin and Fas ligand are required for acute target cell lysis . ^^^ This potent TNF cytotoxicity has not been fully appreciated previously because of the presence of dominant acting perforin and Fas ligand in acute tumor cell lysis . ^^^ Thus , LAK cells are armed with at least three cytotoxic molecules : perforin , Fas ligand , and TNF . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
T cells from mice homozygous for this mutation overexpress the counter receptor , Fas ligand . ^^^ In this study , we investigated the effects and regulatory influences attributable to Fas ligand overexpression on lymphocyte development to clarify the role of Fas system mediated apoptosis in lymphopoiesis in vivo . ^^^ Nonirradiated severe combined immunodeficient ( SCID ) mice grafted with a fetal thymus ( FT ) plus fetal liver cells ( FLC ) from MRL lpr / lpr mice ( Fas Ag defective mice ) , or with FT from C3H gld / gld mice ( Fas ligand defective mice ) plus FLC from C3H + / + mice , developed FLC derived T and B cells . ^^^ Thy 1 . 1 + cells from chimera 1 expressed Fas ligand mRNA about threefold higher than those from chimera 2 , and seven to eightfold higher than Thy 1 . 2+ cells from SCID mice grafted with FT from MRL + / + Thy 1 . 2 mice by Northern blot analysis . ^^^ These findings indicate that overexpression of Fas ligand on T cells significantly impairs both T and B cell development . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
GC T cells expressing both CD40L and Fas ligand have a dual function on GC B cells , helper or killer , depending on the status of target B cells . ^^^ In the later stage , GC T cells kill B cells via Fas Fas ligand interactions unless GC B cells are positively selected by Ags present on FDC . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand and perforin are the two key effector mechanisms in T cell mediated cytotoxicity . ^^^ However bcl 2 ' s effect on Fas ligand and perforin induced lysis has not been studied extensively . ^^^ We investigated the effect of overexpression of bcl 2 alone , Fas alone or their combined overexpression on lysis of a commonly used target , P 815 , by perforin sufficient , Fas ligand sufficient and perforin deficient or Fas ligand deficient , allospecific cytotoxic T lymphocytes ( CTL ) . ^^^ Wild type P 815 are susceptible to lysis by perforin sufficient CTL , regardless of the presence or absence ( gld ) of Fas ligand , but are poorly lysed by perforin deficient CTL . ^^^ Fas transfection of P 815 makes target cells highly susceptible to lysis by both perforin sufficient and deficient CTL , indicating the presence of the Fas ligand mediated cytotoxicity on both types of CTL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Differential regulation of Fas ( CD 95 ) versus Fas ligand expression by cyclosporin A and FK 506 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
C20 , previously stimulated to express Fas ligand ( FasL ) on their surface , as effectors and U 937 or U 937 rho0 cells ( depleted of mitochondrial DNA ) as targets . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
An aggressive nasal lymphoma accompanied by high levels of soluble Fas ligand . ^^^ Fas ligand ( FasL ) , either in the membrane bound form or soluble form , has cytotoxic activity against Fas expressing cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Differential expression of Fas ( CD 95 ) and Fas ligand on normal human phagocytes : implications for the regulation of apoptosis in neutrophils . ^^^ The Fas / Fas ligand pathway has been implicated as an important cellular pathway mediating apoptosis in diverse cell types . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The complementary receptor pair Fas ligand : Fas controls apoptosis during activation induced cell death ( AICD ) of peripheral T cells sensitized for the Fas signal pathway by interleukin 2 ( IL 2 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand by human cytotrophoblasts : implications in placentation and fetal survival . ^^^ Recent data indicated that local production of Fas ligand ( FasL ) by cells of the eye and testis may confer immune tolerance at these sites . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recent data suggest that activated T and B cells , as well as immature lymphocytes , are susceptible to programmed cell death and that Fas : Fas ligand ( FasL ) interactions play an important role in this process . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease . ^^^ The apoptosis genes , fas and fas ligand ( fasL ) , are candidate contributory genes in human SLE , as mutations of these genes result in autoimmunity in several murine models of this disease . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Strong T cell receptor stimulation leads to the synthesis of death molecules such as Fas ligand and tumor necrosis factor that cause T cell suicide . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Since the TCR induced death of both human T blasts and the murine T cell hybridoma 2B4 involve an initial step of TCR induced Fas ligand ( FasL ) up regulation followed by a lethal step induced by Fas cross linking , both steps were examined separately for ROI dependence . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas antigen and Fas ligand in the rheumatoid synovial tissue . ^^^ To understand the role of apoptosis through Fas / Fas ligand ( Fas L ) interaction in the pathogenesis of rheumatoid arthritis ( RA ) , we examined the expression of Fas antigen , Fas L , and apoptosis in synovial tissue obtained from eight patients with RA and five patients with osteoarthritis ( OA ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CONCLUSION : This finding suggests that the Fas antigen may play a role in the pathogenesis of sialoadenitis in SS by providing a specific target for cytotoxic T cells expressing the Fas ligand . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Surface molecules involved in activation induced apoptosis involve Fas and Fas ligand ( FasL ) , as well as the T cell receptor ( TCR ) which modulates the expression and function of these molecules . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cytotoxic T lymphocytes ( CTL ) kill target cells by perforin mediated pore formation , induction of apoptosis by the Fas ligand , or both . ^^^ We found that neurons express only low levels of Fas ( APO 1 / CD95 ) and are resistant to Fas ligand mediated killing even when pretreated with cytokines . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Involvement of Fas ligand and Fas mediated pathway in the cytotoxicity of human natural killer cells . ^^^ Fas ligand mRNA was expressed in freshly isolated NK cells . ^^^ We concluded that Fas ligand / Fas interaction is present and plays a significant role in the human NK cell induced apoptosis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Proteins that modulate apoptosis include bcl 2 , which inhibits apoptosis , and Fas ( CD 95 , also known as APO 1 ) , which induces apoptosis in susceptible cells bound by Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand is a type 2 membrane protein and induces apoptosis by binding to Fas . ^^^ Fas ligand is expressed in activated T cells , and works as an effector of cytotoxic lymphocytes . ^^^ Molecular and genetic analysis of Fas and Fas ligand indicated that mouse lymphoproliferation mutation ( lpr ) and generalized lymphoproliferative disease ( gld ) are mutations of Fas and Fas ligand respectively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A possible involvement of Fas Fas ligand signaling in the pathogenesis of murine autoimmune gastritis . ^^^ Fas ligand message was induced on activated 2 6 cells and caused DNA fragmentation of the antigen pulsed A20 . 2J cells . ^^^ CONCLUSIONS : Cognate interaction between Fas antigen on the target and Fas ligand on the effector seems to be one possible mechanism for the target cell destruction in organ specific autoimmune gastritis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand , recently detected on the surface of cytotoxic T cell , is thought to induce cells to apoptosis by adhering to Fas antigen . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Because ligation of Fas can result in costimulation of proliferation or the induction of apoptosis in uninfected cells , we evaluated the effect on T cells of Fas activation by monoclonal antibodies ( MAb ) of different specificity from both UB 2 and CH 11 clones and activation by the Fas ligand ( Fas L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Binding of Fas ligand to the Fas / APO 1 receptor transduces an apoptotic signal that requires activation of interleukin 1beta converting enzyme ( ICE ) and CPP32beta , members of a family of cysteine proteases that are evolutionarily conserved determinants of cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of Fas antigen , Fas ligand , and T cell subpopulations was examined using flow cytometry and reverse transcription polymerase chain reaction . ^^^ Fas ligand was overexpressed only in synovial nonadherent cells in RA at the level of mRNA , whereas T cells account for more than 60 % of the total , but not in OA . ^^^ CONCLUSION : These findings suggest the majority of activated T cells infiltrating the synovium express functional Fas antigen and Fas ligand specifically in patients with RA but not OA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The lpr and gld genes have been shown to encode the Fas antigen deletion mutant and the Fas ligand ( FasL ) mutant , respectively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Crosslinking the Fas ( CD 95 , APO 1 ) antigen by mAb or Fas ligand ( Fas L ) expressing cells triggers apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The cytocidal activity of OK 432 activated mononuclear cells against human glioma cells is partly mediated through the Fas ligand / Fas system . ^^^ In order to elucidate the mechanism of OK MCs ' cytotoxicity , we examined the expression of Fas ligand mRNA in OK MCs and the cytocidal activity of these cells against a human glioma cell line , T98G which expresses a high level of Fas . ^^^ The expression of Fas ligand mRNA was low in non treated peripheral blood mononuclear cells and was elevated by treatment with OK 432 , irrespective of the dose employed . ^^^ Apoptosis of T98G cells induced by OK MCs was unequivocally inhibited by the pretreatment of T 98 G cells with ZB 4 monoclonal antibody , which binds to Fas and blocks the binding of Fas ligand to Fas . ^^^ These data indicate that the cytotoxic activity of OK MCs via apoptosis seems to be at least partly mediated by the Fas ligand / Fas system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunohistochemical methods were used to search for Fas receptor / Fas ligand system involvement in multiple sclerosis ( MS ) white matter brain lesions . ^^^ We found large numbers of Fas ligand ( Fas L ) bearing cells present in two acute lesions and 12 of 16 chronic MS lesions , and very few positive cells in non inflammatory controls . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Previous work indicated that a subclass of mouse spleen dendritic cells ( DC ) , those bearing CD8alpha , expresses the Fas ligand and restricts peripheral CD 4 T cell responses by initiating Fas mediated apoptosis . ^^^ In contrast with CD 4 T cells , the reduced proliferation of CD 8 T cells occurred even with T cells from Fas deficient Ipr mice , or with DC from Fas ligand deficient gld mice , indicating that Fas induced apoptosis was not involved . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Restimulation of T cell blasts up regulates Fas and Fas ligand expression , with subsequent interaction leading to cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis of mouse naive T cells induced by recombinant soluble Fas ligand and activation induced resistance to Fas ligand . ^^^ We have investigated the susceptibility of mouse T cells at various maturation and activation stages to recombinant soluble mouse Fas ligand ( termed WX 1 ) . ^^^ Activation induced cell death of previously activated T cells is known to be mediated by Fas and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
IFN gamma inducing factor up regulates Fas ligand mediated cytotoxic activity of murine natural killer cell clones . ^^^ They constitutively expressed Fas ligand ( FasL ) and specifically killed Fas positive target cells by fragmenting DNA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Like CD40L , Fas ligand is expressed on activated CD4+ Th 1 cells and when bound to Fas receptor on the B cell surface , initiates an apoptotic signal in that cell . ^^^ Thus , CD4+ T cells limit the growth of autologous germinal center B cells by first inducing Fas expression and then instigating a death signal via Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The interaction between Fas ligand and Fas , both expressed on activated T cells , is the major pathway in the regulation of activation induced cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Our studies on the Fas ligand and Fas have indicated that apoptosis is also mediated by a cytokine and its receptor in some cases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TCR alpha / beta and TCR gamma / delta CD 4 / CD8 HLA DR alloreactive CTL clones do not use Fas / Fas ligand pathway to lyse their specific target cells . ^^^ The expression of Fas Ligand ( FasL ) on human TCRalpha / beta and TCRgamma / delta CD 4 / CD8 MHC class 2 alloreactive clones and Fas / FasL mediated cytotoxicity were investigated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND / AIMS : Fas transduces apoptotic signals upon cross linking with the Fas ligand , which is experimentally replaced by anti Fas antibodies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interferon gamma inducing factor , a novel cytokine , enhances Fas ligand mediated cytotoxicity of murine T helper 1 cells . ^^^ Fas ligand ( FasL ) , expressed on activated T cells , plays a central role in regulating the immune response by inducing apoptosis in activated lymphocytes through binding to its receptor , Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here , we used perforin deficient C57BL / 6 ( PKO ) mice to study involvement of perforin and Fas ligand in tumor surveillance in vivo . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The possibility of eradicating tumor cells in vivo with anti Fas antibody was investigated using double mutant gld / gld lpr / lpr mice which lack both Fas ligand ( FasL ) and Fas to avoid cytotoxic activity of the antibody to the liver and interference from endogenous FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Contribution of Fas ligand to cardiac allograft rejection . ^^^ In the present study , we verified the contribution of Fas and Fas ligand ( FasL ) to cardiac allograft rejection by utilizing the Fas deficient lpr or FasL deficient gld mice as the donor or recipient . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The cell surface protein Fas ( APO 1 ) is a member of the tumor necrosis factor receptor ( TNFR ) superfamily and transduces apoptosis following binding of Fas ligand or exposure to certain anti Fas antibodies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Using reverse transcription polymerase chain reaction analysis , both IL 15 and IL 2 have been shown to induce the expression of mRNAs for perforin , granzymes A and B , interferon gamma , and Fas ligand in primary murine splenic lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
More recently , gld ( generalized lymphadenopathy ) has been shown to be a point mutation in the Fas ligand gene . ^^^ These data indicate that the gld defect is extrinsic to B cells but only partially extrinsic to T cells , and suggest that Fas ligand in T cells may have an autocrine and paracrine function . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas receptor ( Fas ) is a membrane signaling protein that mediates a death signal following its aggregation by the Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
ALG 3 , a truncated mouse homologue of the chromosome 1 familial Alzheimer ' s disease gene PS 2 , rescues T hybridoma 3DO cells from T cell receptor induced apoptosis by inhibiting Fas ligand induction and Fas signaling . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
For example , apoptotic death depends on the balance of Fas , Fas ligand , nuclear factors ( eg , bcl 2 , bax , and myc ) , cytokines , neuropeptides , and cell membrane interactions with extracellular matrix . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand and immune evasion . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Constitutive Fas ligand expression in several non lymphoid mouse tissues : implications for immune protection and cell turnover . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To directly examine whether Fas ligand has a major role in the development of acute graft vs host disease ( GVHD ) , Fas ligand deficient ( gld ) mice were used as donors and C3H / HeJ 10 C57BL / 6F1 as recipients in the parent into F 1 model of acute GVHD . ^^^ These findings not only indicate that the Fas ligand is an important effector molecule in acute GVHD , but also provide in vivo evidence supporting a role for Fas / Fas ligand interactions in T cell expansion and maturation . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The majority of LAK killing was dependent upon extracellular calcium , supporting the hypothesis that granule exocytosis rather than Fas ligand was the principal pathway leading to target cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Effector cells generated in gld mice that have a mutated Fas ligand displayed apparently normal levels of cytotoxicity against human target cells , suggesting a predominantly perforin based cytotoxic mechanism . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Regulation of apoptosis through altered expression of Fas ligand and Fas genes ] . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Herpes simplex virus type 2 inhibition of Fas ligand expression . ^^^ In this report we demonstrate the capacity of HSV 2 , but not HSV 1 , to inhibit the activity and cell surface expression of Fas ligand , an important molecule involved in T cell apoptosis and cell mediated cytotoxicity . ^^^ Cells infected with HSV 2 retained Fas ligand intracellularly instead of expressing it on the cell surface . ^^^ Addition of anti Fas antibodies markedly inhibited HSV 2 viral production , suggesting that the capacity of the virus to regulate Fas ligand expression , and thereby programmed cell death , may represent a powerful mechanism for the virus to enhance viral replication . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis of Fashigh CD4+ synovial T cells by borrelia reactive Fas ligand ( high ) gamma delta T cells in Lyme arthritis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , anti Fas immunoglobulin G strongly inhibited the [ 3H ] thymidine uptake of CEM cells in proliferative assays , inducing a suppression as high as provoked by both CH 11 mAb and recombinant human Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas is a cell surface receptor that transduces cell death signals when cross linked by agonist antibodies or by fas ligand . ^^^ In such lesions , microglia and infiltrating lymphocytes displayed intense immunoreactivity to fas ligand . ^^^ Fas ligation with the anti fas monoclonal antibody M 3 or with the fas ligand induced rapid OL cell membrane lysis , assessed by LDH release and trypan blue uptake and subsequent cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The markers included DNA breaks detected by TUNEL , Fas ( CD95 / APO 1 ) and Fas ligand ( Fas L ) localized by immunohistochemistry , electron microscopic features of apoptosis , and laddering of extracted DNA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Almost all CD4+ T cells from repopulated lymphoid tissues of transplanted SCID mice express CD 95 ( Fas ) on the cell surface , and a large fraction of CD4+ T cells from the gut lamina propria of transplanted SCID mice express the Fas ligand on the surface . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Molecular executors of cell death differential intrarenal expression of Fas ligand , Fas , granzyme B , and perforin during acute and / or chronic rejection of human renal allografts . ^^^ Reverse transcriptase polymerase chain reaction was used to identify intrarenal expression of Fas antigen , Fas ligand , granzyme B and perforin in eighty human renal allograft biopsies ; mRNA display was correlated with the Banff histological diagnosis of renal allografts . ^^^ Our studies demonstrate that : ( 1 ) intrarenal expression of Fas ligand mRNA and of granzyme B mRNA are correlates of acute but not chronic rejection ; ( 2 ) Fas ligand mRNA is not detectable in allografts in the absence of rejection ; ( 3 ) intrarenal coexpression of members of each lytic pathway ( Fas ligand and Fas , granzyme B , and perforin ) and that of both pathways ( e . g . , Fas ligand and granzyme B ) are correlates of acute rejection ; and ( 4 ) a direct correlation exists between the histological severity of acute rejection and intrarenal coexpression of mRNA encoding Fas ligand , Fas , granzyme B , and perforin . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Wild type C57BL / 6 ( B 6 ) , perforin deficient C57BL / 6 ( B 6 PKO ) and Fas ligand deficient ( B 6 gld / gld ) mice were grafted with xenogeneic Lewis rat skin grafts , or allogeneic B10 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This process is believed to play an important role in the regulation of immune homeostasis and is suggested to be mediated mainly by interactions between Fas and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To analyze the pathogenesis of apoptosis in labial salivary glands of SS patients , we examined the expression of Fas Ag and Fas ligand ( FasL ) and TCR on T cells susceptible to anti Fas mAbs ( CH 11 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In mice functionally deficient for either Fas or Fas ligand expression , the failure of Fas ligand expressing cytotoxic T cells to eliminate autoreactive B cells can result in excessive autoantibody production . ^^^ Recent in vitro studies have shown that B cells activated by CD 40 ligand become extremely sensitive to Fas mediated apoptosis while IL 4 and / or surface IgM receptor engagement protects B cells from Fas ligand cytolysis . ^^^ Potential in vivo sites for Fas ligand regulation of self reactive B cells have been suggested and implications for human disease have been investigated . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Regulation of Fas and Fas ligand expression in cultured murine renal cells and in the kidney during endotoxemia . ^^^ Fas ligand ( FasL ) and Fas belong to a recently described family of cytokines and receptors with similarities to tumor necrosis factor ( TNF ) and its receptors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis and expression of Fas / Fas ligand mRNA in bleomycin induced pulmonary fibrosis in mice . ^^^ The incidence of apoptosis and the expression of Fas antigen ( Fas ) / Fas ligand ( FasL ) mRNA in bleomycin induced pulmonary fibrosis in mice were examined . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand expression in the salivary glands of patients with primary Sjgren ' s syndrome . ^^^ METHODS : Expression of Fas , Fas ligand ( FasL ) , and bcl 2 in salivary gland biopsy material was detected in situ by immunohistochemical staining and reverse transcriptase polymerase chain reaction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
During acute renal allograft rejection intragraft expression of the interleukin ( IL ) 7 ( P < 0 . 001 ) , IL 10 ( P < 0 . 0001 ) , IL 15 ( P < 0 . 0001 ) , Fas ligand ( P < 0 . 0001 ) , perforin ( P < 0 . 0001 ) , and granzyme B ( P < 0 . 0015 ) , but not IL 2 , interferon gamma , or IL 4 , genes is significantly heightened . ^^^ A simultaneous RT PCR evaluation of perforin , granzyme B , and Fas ligand identifies acute rejection , including cases with mild infiltration , with extraordinary sensitivity ( 100 % ) and specificity ( 100 % ) . ^^^ The combined analysis of Fas ligand , perforin , and granzyme B gene expression by quantitative RT PCR provides a reliable tool for diagnosis and follow up of acute renal allograft rejection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Release of preformed Fas ligand in soluble form is the major factor for activation induced death of Jurkat T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This susceptibility was paralleled by increased Fas ligand expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although anatomical barriers and soluble mediators have been implicated in immune privilege , it appears that the apoptotic cell death of Fas+ cells by tissue associated CD 95 ligand ( Fas ligand , FasL ) is an important component . ^^^ Since the mouse cornea expresses abundant Fas ligand and immune privilege has been implicated in the success of these transplants , we examined the role of FasL in corneal transplantation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The cell surface protein Fas ( CD 95 ) and its ligand play a pivotal role in regulating lymphocyte apoptosis , and defective expression of either Fas or Fas ligand results in marked over accumulation of mature lymphocytes and autoimmune disease in mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Role of Fas ligand and receptor in the mechanism of T cell depletion in acquired immunodeficiency syndrome : effect on CD4+ lymphocyte depletion and human immunodeficiency virus replication . ^^^ The Fas receptor / Fas ligand ( Fas R / Fas L ) system mediates signals for apoptosis of susceptible lymphocytes and lympoblastoid cell lines . ^^^ A number of investigators have recently reported increased expression of the Fas receptor in individuals with HIV infection , along with increased sensitivity of their lymphocytes to anti Fas antibody mimicking Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To analyze the pathogenesis of apoptosis in rheumatoid synovium , we examined the expression of Fas Ag , Fas ligand ( Fas L ) , and TCR on T cells susceptible to anti Fas mAbs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
YAC 1 and Jurkat expressed Fas and were susceptible to anti Fas MAb or rhuman Fas ligand ( rhFasL ) induced lysis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Lethal effect of recombinant human Fas ligand in mice pretreated with Propionibacterium acnes . ^^^ Fas ligand ( FasL ) is a type 2 membrane protein . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Total protein levels of the Fas receptor ( Fas ; APO 1 / CD 95 ) and the Fas ligand ( Fas L ) were increased following VES treatment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas , a member of the tumor necrosis factor receptor / nerve growth factor receptor family , induces apoptosis by crosslinking with Fas ligand or anti Fas antibody in a variety of cultured cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Spleen and lymph nodes cells spontaneously lyse Fas targets ( thymocytes ) through a Fas mediated mechanism as a consequence of their overexpression of Fas ligand ( FasL ) confirmed by semiquantitative reverse transcription ( RT ) PCR and immunoprecipitation analysis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Antibody interaction with a specific epitope of the HLA class 1 alpha 1 domain triggers apoptosis of activated but not resting T and B cells by a pathway which involves neither Fas ligand nor tumor necrosis factor alpha . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This article reviews progress in deciphering the mechanisms by which they kill target cells through induction of apoptosis by either the secretory , perforin / granzyme based pathway or the nonsecretory pathway , ( i . e . , by triggering the cell surface death receptor Fas ( CD 95 ) by the membrane bound Fas ligand of the killer ) . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In situ expression of protooncogenes and Fas / Fas ligand in rheumatoid arthritis synovium . ^^^ OBJECTIVE : To examine the relationship among the expression of protooncogenes such as c fos and c myc , Fas antigen , Fas ligand , and apoptosis in the synovial tissue of patients with rheumatoid arthritis ( RA ) . ^^^ METHODS : The expression of c fos , c myc , Fas antigen , and Fas ligand was examined in synovial tissues of 6 patients with RA and 4 with osteoarthritis ( OA ) using in situ reverse transcriptase ( RT ) assay and immunohistochemical staining . ^^^ Fas ligand mRNA was detected only in mononuclear cells in RA synovium . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interestingly , in contrast to the situation found in infected humans , Fas ligation by agonistic Abs or recombinant human Fas ligand on CD 4 and CD 8 T cells from infected chimpanzees did not induce apoptosis in these subsets even when Bcl 2 was down regulated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
One mechanism of apoptosis is through the interaction of the cell surface Fas receptor on target cells and the Fas ligand that is expressed on cytotoxic T cells . ^^^ The purpose of this study was to look for evidence of myocardial Fas receptor , Fas ligand , and apoptosis in a murine heterotopic heart transplantation model of chronic rejection / graft vasculopathy . ^^^ MRNA for the Fas receptor , Fas ligand , and beta actin was detected with reverse transcription polymerase chain reaction . ^^^ In contrast , allografts showed a strong signal for the Fas ligand mRNA , a signal not seen in syngeneic grafts or native hearts . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas counterattack : Fas mediated T cell killing by colon cancer cells expressing Fas ligand . ^^^ In this report , we demonstrate that the colon cancer cell SW 620 expresses functional Fas ligand ( FasL ) , the triggering agent of Fas receptor ( FasR ) mediated apoptosis within the immune system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Human lung carcinomas express Fas ligand . ^^^ Activated T cells may enter apoptosis in the presence of Fas ligand ( FasL ) ( 1 ) , and tissue expression of FasL has been shown to contribute to immune privilege in the eye and testis ( 2 , 3 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Previously , a high expression of the Fas ( CD95 / APO 1 ) / Fas ligand system in peripheral blood mononuclear cells from HIV positive individuals has been reported and could be responsible for the observed relevant apoptosis of both infected and uninfected cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas antigen ( Fas ) and Fas ligand participate in cytotoxicity mediated by T lymphocytes and natural killer cells . ^^^ Like Fas ligand , anti Fas monoclonal antibody ( MoAb ) induces apoptosis of the cells expressing Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , TNF alpha , Fas ligand , presumably acting through receptors with a death domain , and androgens are atretogenic factors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression by astrocytoma in vivo : maintaining immune privilege in the brain . ^^^ Here , we propose that cell contact mediated events also play a role , since we demonstrate the in vivo expression of Fas ligand ( FasL / CD95L ) by human astrocytoma and the efficient killing of Fas bearing cells by astrocytoma lines in vitro and by tumor cells ex vivo . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To test whether immune disorders in the host may influence bone formation , we studied BMP induced bone formation in a C3H / HeJ strain of mice bearing a mutant gene , the lymphoproliferation gene ( lpr ) or the generalized lymphoproliferative disease gene ( gld ) , both of which are known to be a Fas deletion mutant and a Fas ligand mutant , respectively , and to induce immune disorders via a deficit in Fas mediated apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In eontrast , PTX had no effect on AK cell expression of Fas ligand , a cell surface cytolytic effector molecule which is involved in granule independent cytotoxicity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Anomalies in programmed cell death have been demonstrated in murine models of lupus : mutations of the fas and fas ligand genes , which play a known role in programmed cell death , produce the lpr and gld phenotypes associating lymphoproliferation and lupus . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Flow cytometry analysis of the Fas ligand expression of activated lymph node T cells . ^^^ There is increasing evidence for the role of the Fas / Fas ligand interaction in the immunoregulation of T cells . ^^^ We studied the expression of the Fas ligand ( FasL ) in activated peripheral T cell in vitro , and its relation to autonomous cell death by flow cytometry . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Stimulation of Fas by Fas ligand or agonistic antibodies results in the activation of interleukin 1 beta converting enzyme like ( ICE like ) proteases , and proteolytic cleavage of poly ( ADP ribose ) polymerase ( PARP ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunologically privileged sites express Fas ligand ( FasL ) , which protects them from attack by activated T cells that express Fas and die upon contact with FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Essential roles of the Fas ligand in the development of hepatitis . ^^^ The Fas ligand ( FasL ) is expressed in activated T cells and induces apoptosis in Fas bearing cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Antigens , T cell signals ( cytokines , CD 40 ligand and Fas ligand ) as well as the activation state of B cells determine their ultimate fate . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Both neutral and acidic sphingomyelinases , which generate the lipid second messenger ceramide , are reported to induce apoptosis following ionizing radiation and other death signals such as tumor necrosis factor alpha and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The NF AT family of transcription factors participates in the regulation of early immune response genes such as IL 2 , IL 4 , CD 40 ligand , and Fas ligand in response to Ca2+ / calcineurin signals initiated at the antigen receptor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD8+ DCs efficiently activate CD4+ T cells but then kill them via Fas ligand on the DC surface . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( APO 1 , CD 95 ) , a transmembrane receptor protein , transmits an apoptotic signal within cells when bound by Fas ligand ( FasL ) . ^^^ Fas ( APO 1 , CD 95 ) , a transmembrane receptor protein , transmits an apoptotic signal within cells when bound by Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ten erythema multiforme and five control oral mucosa biopsy specimens were evaluated in immunohistochemically stained sections for apoptosis regulating proteins Bcl 2 , Bcl 10 , Bax , p 53 , Fas , and Fas ligand . ^^^ Only slight differences in staining patterns of Fas and Fas ligand proteins were noted between erythema multiforme and controls . ^^^ Although measurable alterations in the phenotypic expression of Fas and Fas ligand proteins were not apparent , activation of Fas / Fas ligand system could still be involved in the induction of apoptosis in erythema multiforme . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas ligand was expressed on TcOSC 20 lines , and its expression was induced upon mixed lymphocyte tumor cell culture of autologous peripheral blood lymphocytes . ^^^ Furthermore , the cytotoxicity of TcOSC 20 was inhibited by anti Fas ligand antibody . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This cell death resulted from Fas / Apo 1 ( CD 95 ) / Fas ligand interactions between the T cells , in that Fas ligand expression was detected following overnight culture of T cells with T APC and neutralizing anti CD 95 Ab protected from death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Analysis of biochemical and biological functions of Fas ligand ( FasL ) and Fas on activated T cells in allo immune response . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand is positioned in mouse uterus and placenta to prevent trafficking of activated leukocytes between the mother and the conceptus . ^^^ To evaluate the postulate that cell traffic is restricted by expression of Fas ligand ( FasL ) in the uterus and placenta , FasL mRNA was identified by using reverse transcription PCR , and FasL protein was identified by Western blotting and immunohistology . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Binding of Fas ligand ( FasL ) or an agonistic anti Fas receptor ( Fas / CD95 ) antibody induces apoptosis in Fas bearing target cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activation of T cells was shown to up regulate the Fas ligand ( FasL ) which binds to the CD 95 ( APO 1 / Fas ) antigen and mediates activation induced cell death ( AICD ) of activated T cells and T lymphoma cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Effector cells generated in immunocompetent and gld ( Fas ligand mutant ) mice predominantly use a perforin mediated cytotoxic mechanism . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Constitutive expression of Fas ligand in large granular lymphocyte leukaemia . ^^^ One mechanism whereby CTL mediate target cell killing is through the Fas / Fas ligand apoptotic pathway . ^^^ Fas ligand is expressed by CTL only after activation . ^^^ In this study we examined seven patients with LGL leukaemia for expression of Fas ligand gene transcripts using reverse transcriptase polymerase chain reaction ( RT PCR ) analyses . ^^^ We found constitutive expression of Fas ligand gene transcripts in each of the seven patients . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Plasma Fas ligand , an inducer of apoptosis , and plasma soluble Fas , an inhibitor of apoptosis , in patients with chronic congestive heart failure . ^^^ OBJECTIVES : This study sought to examine plasma levels of soluble Fas / APO 1 receptor ( sFas ) , an inhibitor of apoptosis , and soluble Fas ligand ( sFas L ) , an inducer of apoptosis , and their relation to each other and to other clinical variables , such as New York Heart Association functional class , tumor necrosis factor ( TNF ) and interleukin 6 ( IL 6 ) in congestive heart failure ( CHF ) . ^^^ Fas and Fas ligand ( Fas L ) are cell surface proteins and representative apoptosis signaling molecules . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The model was analyzed in the light of information provided by studies on TNFR and CD 40 , another member of the TNFR family , and the Fas ligand binding site was predicted . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NK cells from tumor rejected animals show higher expression of Fas ligand and serine esterase granzyme B . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / APO 1 mediates apoptosis via Fas and Fas ligand transduction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Contribution of TNF / TNF receptor and of Fas ligand to toxicity in murine models of endotoxemia and bacterial peritonitis . ^^^ Fas / Fas ligand and TNF / TNF receptors are involved in apoptosis . ^^^ We investigated the role of TNF / TNFR and Fas / Fas ligand in models of endotoxemia and of speticemia in mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Role of Fas ligand ( CD95L ) in immune escape : the tumor cell strikes back . ^^^ Several different tumor types have recently been shown to express functional Fas ligand ( FasL ) , which may represent an additional mechanism of tumor escape . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The similarity between this syndrome and that in mice with the lymphoproliferation ( lpr ) phenotype or the generalized lymphoproliferative disease ( gld ) phenotype led us to investigate whether it too is caused by mutations of the Fas gene ( lpr mice ) or the Fas ligand ( gld mice ) , which regulate apoptosis in lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To determine whether the Fas Fas ligand mediated apoptosis occurs in the pathologic process of human muscle diseases , we examined the expression of Fas antigen , Fas ligand messenger RNA , and chromosomal DNA fragmentation in the muscle cells of patients with a variety of human muscle disorders . ^^^ However , the apoptotic process did not occur in the muscle cells , and there was no evidence of Fas ligand synthesis in the diseased muscle tissue . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Induction of human IgE synthesis in B cells requires , in addition to IL 4 or IL 13 , a second signal provided by CD 40 ligand ( CD40L ) on activated Th 2 type CD4+ T cells that do not or weakly express Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand deficiency in HIV disease . ^^^ The Fas Fas ligand interaction is a powerful regulator of T cell apoptosis and could potentially act as a potent anti viral immune mechanism against T cell tropic virus such as human immunodeficiency virus ( HIV ) . ^^^ We investigated the status of Fas ligand in peripheral blood mononuclear cells ( PBMCs ) obtained from persons infected with HIV . ^^^ We found that monocytes in freshly isolated PBMCs from healthy individuals possess cell surface Fas ligand . ^^^ In contrast , monocytes in freshly isolated PBMCs from HIV infected patients had no detectable Fas ligand on the cell surface . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In vitro studies suggest that these soluble Fas isoforms inhibit apoptosis induced by agonistic antibodies and , more importantly , by the natural Fas ligand in Fas bearing sensitive cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Stimulation of activated T cells upregulates the expression of the Fas ligand , and the interaction of Fas ligand with the corresponding Fas receptor triggers an apoptosis program that culminates in cellular suicide usually associated with the fragmentation of DNA into oligonucleosomal bands . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , the decrease appeared to be related to the expression of Fas / APO 1 ( CD 95 ) and Fas ligand ( Fas L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interferon gamma ( IFN gamma ) , tumour necrosis factor alpha ( TNF alpha ) and Fas ligand can mediate potent inhibitory signals in haemopoietic cells . ^^^ These results suggest that , in addition to interacting at the level of intracellular signalling pathways , IFN gamma , TNF alpha or Fas ligand may potentiate or antagonize their effects through modulation of cytokine receptor expression . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Perforin , Fas / Fas ligand , and TNF alpha pathways as specific and bystander killing mechanisms of hepatitis C virus specific human CTL . ^^^ In chronic hepatitis C , Fas expression is up regulated in the hepatocytes , especially near liver infiltrating lymphocytes , and Fas ligand is expressed on the lymphocytes . ^^^ We also show that the killing of Ag presenting , sensitive cells is mediated by Fas ligand and TNF alpha as well as perforin , although the latter plays a major role in the killing at a low E : T ratio , and that the killing of sensitive bystander cells is primarily mediated by Fas ligand and TNF alpha on CTLs expressed upon specific Ag stimulation , which may be relevant to the bystander lysis by HCV specific CTLs of uninfected hepatocytes , in which Fas expression is up regulated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the present study , we examined the mechanisms responsible for granzyme B independent cytotoxicity using in vitro lytic assays with CTLs derived from mice deficient for both granzyme B and Fas ligand ( FasL ) ( granzyme B / 10 gld / gld ) or for perforin and FasL ( perforin 10 gld / gld ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The CD 95 transfected K 562 cells stably expressed CD 95 , and had a growth pattern comparable to untransfected cells , but still remained resistant to Fas triggering ( tested using recombinant Fas ligand ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Fas ligand interaction contributes to UV induced apoptosis in human keratinocytes . ^^^ Furthermore , keratinocytes constitutively expressed Fas ligand ( FasL ) mRNA and protein . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In order to understand the molecular basis of PMN apoptosis , the expression of apoptosis related ( Fas , Fas ligand , p 53 , and c myc ) and survival related ( bcl 2 ) genes was detected by flow cytometry , Western blot and reverse transcription assisted polymerase chain reaction ( RT PCR ) . ^^^ We found that Fas and Fas ligand ( FasL ) were expressed on the surface of most of the cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recently , perforin and Fas ligand have been shown to be the only molecules causing T cell mediated cytotoxicity in short term assays . ^^^ Furthermore , Fas ligand expression was detected in liver infiltrating mononuclear cells obtained from patients with chronic hepatitis C . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Agonist antibody and Fas ligand mediate different sensitivity to death in the signaling pathways of Fas and cytoplasmic mutants . ^^^ We transfected cell lines with these constructs to compare the relative capacity of antibody agonists and the physiological Fas ligand ( FasL ) to stimulate death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand and its receptor in cutaneous lupus : implication in tissue injury . ^^^ Fas ligand ( FasL ) is a type 2 membrane protein which belongs to the tumor necrosis factor family . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL ) is a member of the tumor necrosis factor family and induces apoptosis in Fas ( CD 95 ) bearing target cells . ^^^ Polymorphism of murine Fas ligand that affects the biological activity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand in liver metastases of human colonic adenocarcinomas . ^^^ Fas ligand ( FasL ) plays a pivotal role in lymphocyte cytotoxicity and the maintenance of immunological homeostasis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Rheumatic diseases in an MRL strain of mice with a deficit in the functional Fas ligand . ^^^ OBJECTIVE : To characterize Fas antigen expression on the cell surface , and to determine the effect of this expression in rheumatic diseases using a newly established gld congenic MRL strain of mice ( MRL / gld ) , which is defective in its functional Fas ligand ( Fas L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
No increase in soluble Fas and Fas ligand in Kawasaki disease : comment on the article by Nozawa et al . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
On stimulation by the Fas ligand , the death receptor , Fas , initiates a signal leading to apoptotic cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activation of the Fas receptor by the Fas ligand or agonistic antibodies triggers apoptosis in some cell types that express Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Forskolin not only inhibited activation induced cell death and NF kappa B activation , but also suppressed expression of Fas and Fas ligand ( Fas L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In studying TCR triggering of perforin or Fas ligand ( FasL ) / Fas ( CD 95 ligand / CD95 ) cytotoxicity in our influenza specific T cell clones , we found that IL 2 can also induce FasL / Fas cytotoxicity . ^^^ IL 2 induces Fas ligand / Fas ( CD95L / CD95 ) cytotoxicity in CD8+ and CD4+ T lymphocyte clones . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( CD95L ) and B 7 expression on dendritic cells provide counter regulatory signals for T cell survival and proliferation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The current study was designed to explore the relative contribution of Fas ligand ( FasL ) , perforin , IFN gamma , and TNF alpha induced death pathways in the pathogenesis of CTL induced liver disease . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand mediated bystander lysis of syngeneic cells in response to an allogeneic stimulus . ^^^ Using a mouse allospecific lymph node ( LN ) CTL ( H 2b ) response to transplanted cells ( H 2k ) , effector cells were shown to lyse C3H / HeJ or L 929 Fas ( H 2k ) target cells in either a perforin dependent or a Fas ligand ( FasL ) dependent manner . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NK cell associated antigens ( CD11c , CD 16 , or CD 56 ) and cytotoxic T lymphocyte ( CTL ) effector proteins ( perforin , granzyme B , TIA 1 , and Fas ligand ) were expressed by each lymphoma ; dense core cytolytic granules were observed by electron microscopy in both lymphomas studied . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Involvement of Fas and Fas ligand interaction in allogeneic hepatocyte rejection in the spleen . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Adenovirus mediated expression of Fas ligand induces hepatic apoptosis after Systemic administration and apoptosis of ex vivo infected pancreatic islet allografts and isografts . ^^^ Fas ligand ( FasL ) mediates apoptosis of Fas bearing cells and is expressed on a limited number of tissues , predominantly activated T lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand in murine ovary . ^^^ Corresponding to the expression of Fas in the ovarian oocytes as previously reported ( Guo et al . , Biochem Biophys Res Commun 1994 ; 203 : 1438 1446 ; Mori et al . , JSIR 1995 ; 9 : 49 50 ) , the expression of Fas ligand ( FasL ) in the ovarian follicle was found to be restricted in the area of granulosa cells by the indirect immunofluorescence ( IIF ) test . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas and Fas ligand in renal grafts with acute and chronic rejection in the rat model . ^^^ We investigated the Fas and Fas ligand level in renal grafts with acute and chronic rejection in a rat model using semiquantitative reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ Fas ligand in renal allografts was detected as early as 1 day after transplantation in an acute rejection model . ^^^ In contrast , Fas ligand in normal kidneys was almost undetectable . ^^^ Fas ligand in isografts was increased , but the expression level was much lower than in allografts . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Regulation of Fas and Fas ligand expression in NK cells by cytokines and the involvement of Fas ligand in NK / LAK cell mediated cytotoxicity . ^^^ This study demonstrates cytokine mediated regulation of Fas and Fas ligand ( Fas L ) expression in human NK cells and the involvement of the Fas L pathway in NK / LAK cytotoxicity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Both perforin and Fas ligand ( FasL ) deficient CTLs show impaired lytic activity toward most target cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Evasion of cytotoxic T lymphocyte ( CTL ) responses by nef dependent induction of Fas ligand ( CD95L ) expression on simian immunodeficiency virus infected cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Upregulation of Fas ligand by simian immunodeficiency virus a nef arious mechanism of immune evasion . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Caspase 8 may be the first enzyme of the proteolytic cascade activated by the Fas ligand and tumor necrosis factor ( TNF ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction . ^^^ Fas ligand is believed to mediate immune privilege in a variety of tissues , including the eye , testis , and a subset of tumors . ^^^ We tested whether expression of Fas ligand on pancreatic islets either following adenoviral or germline gene transfer could confer immune privilege after transplantation . ^^^ Islets were infected with an adenoviral vector containing the murine Fas ligand cDNA ( AdFasL ) , and were transplanted into allogenic diabetic hosts . ^^^ Similarly , transgenic mice expressing Fas ligand in pancreatic beta cells developed massive neutrophilic infiltrates and diabetes at a young age . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Transplanted grafts of pancreatic islet cells engineered to express Fas ligand are destroyed not protected by the immune system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / APO 1 ( CD 95 ) is a cell surface receptor that mediates apoptosis when it reacts with Fas ligand ( FasL ) or Fas antibody . ^^^ Fas ligand expression in glioblastoma cell lines and primary astrocytic brain tumors . ^^^ Fas / APO 1 ( CD 95 ) is a cell surface receptor that mediates apoptosis when it reacts with Fas ligand ( FasL ) or Fas antibody . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased lymphocyte apoptosis in Fas ligand transgenic mice . ^^^ Fas ligand ( fasL ) transgenic ( Tg ) mice were produced by introducing a murine fasL cDNA under the control of a TCR beta chain enhancer minigene . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In lpr ( cg ) and lpr mice lacking functional Fas , gld mice lacking functional Fas ligand and lpr ( cg ) gld mice lacking both functional Fas and Fas ligand , the experimental cryptorchidism also induced apoptosis in germ cells at 1 p . c . day . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) and Fas ligand ( FasL ) have been implicated in the pathogenesis of graft versus host disease ( GVHD ) , which is a major complication after allogeneic bone marrow transplantation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A cysteine protease inhibitor prevents activation induced T cell apoptosis and death of peripheral blood cells from human immunodeficiency virus infected individuals by inhibiting upregulation of Fas ligand . ^^^ In the first two cases , apoptosis is caused by the upregulation of Fas ligand ( FasL ) and its subsequent interaction with Fas ; the mechanism for the spontaneous and activation induced death of lymph node cells and PBL from HIV+ blood is not known . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Elevated serum level of Fas ligand correlates with the asymptomatic stage of human immunodeficiency virus infection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Autologous killing by a population of intermediate T cell receptor cells and its NK1 . 1+ and NK1 . 1 subsets , using Fas ligand / Fas molecules . ^^^ Fas ligand ) were used as effector cells ( target thymocytes of MRL ( ) + / + mice ) . ^^^ Consistent with the results of a functional assay , it was found by reverse transcription polymerase chain reaction ( RT PCR ) assay that CD3int cells among liver MNC showed the expression of Fas ligand mRNA , while thymocytes expressed Fas mRNA . ^^^ These results suggest that autologous killing is a major function of TCRint cells with self reactivity , and that such killing is mediated by means of Fas ligand / Fas molecules . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand is not only expressed in immune privileged human organs but is also coexpressed with Fas in various epithelial tissues . ^^^ AIMS : To confirm the recent data obtained in mice , showing that the Fas ligand ( FasL ) is involved in the phenomenon of `` immune privilege ' ' ( the apparent defect of the immune system in specific anatomical sites ) and to extend this finding to humans . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
ZAP 70 tyrosine kinase is required for the up regulation of Fas ligand in activation induced T cell apoptosis . ^^^ Activation induced cell death ( AICD ) is initiated by the TCR dependent up regulation of Fas ligand ( FasL ) mRNA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunotolerance induced by intratesticular antigen priming : expression of TGF beta , Fas and Fas ligand . ^^^ In order to understand the mechanism by which the signal or signal carrier is generated , they determined in this study changes in immunoreactivity for transforming growth factor beta ( TGF beta ) , IFN gamma , IL 2 , Fas and Fas ligand in the testis following an injection of S Ag . ^^^ Immunoreactivity for Fas and Fas ligand was detected both in control and experimental testes and did not change appreciably with time following Ag priming of the testis . ^^^ Fas immunoreactivity was found in spermatids and virtually absent in the interstitial tissue , while Fas ligand immunoreactivity was primarily associated with the interstitial cells such as Leydig cells . ^^^ Fas ligand immunoreactivity was very weak , if any , in the germ cells and Sertoli cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cytotoxic T lymphocytes and natural killer ( NK ) cells kill target cells by two main mechanisms , namely , the perforin / granzymes and the Fas ligand ( Fas L ) pathways . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunohistochemical analyses of granzyme B , perforin , Fas ligand , and tumor necrosis factor alpha demonstrated these proteins were not expressed by small intestinal IELs in situ . ^^^ In contrast to these in situ results , isolated and in vitro activated IELs were shown to express effector proteins consistent with cytolytic T cells , including granzyme B , Fas ligand , tumor necrosis factor alpha , and interferon gamma . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas , a type 1 membrane receptor protein , transduces a signal culminating in apoptosis after binding to the Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Role for NK cell associated Fas ligand in cell mediated cytotoxicity and apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In an attempt to determine whether the Fas Fas ligand mediated apoptosis operates in the pathologic process of human myopathies , we examined the expression of Fas antigen , the synthesis of Fas ligand mRNA , and the presence of chromosomal DNA fragmentation in the muscles from patients with various human muscle disorders . ^^^ Furthermore , no Fas ligand synthesis was detected in the diseased muscle tissue by RT PCR method . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( Apo 1 / CD95 ) , a receptor belonging to the tumor necrosis factor receptor family , induces apoptosis when triggered by Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Human monocytic cells contain high levels of intracellular Fas ligand : rapid release following cellular activation . ^^^ Human monocytes express both Fas and Fas ligand ( FasL ) on the cell surface , and the interaction of these molecules induces spontaneous apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TCR induced Fas ligand ( FasL ) expression is demonstrated to be dependent on Lck SH 2 and kinase activities , although FasL expression can not be correlated with apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We found that Fas ligand is an important independent mediator of class 2 restricted acute murine GvHD , while perforin / granzyme dependent mechanisms have only a minor role in that compartment . ^^^ In contrast , perforin / granzyme dependent mechanisms are required for class 1 restricted acute murine GvHD , while Fas ligand is not . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Progressive B cell apoptosis and expression of Fas ligand during human immunodeficiency virus type 1 infection . ^^^ B cells from HIV 1 infected individuals were found to express Fas ligand , and the expression of this protein correlated with the levels of apoptosis in the same cells . ^^^ Non B cells , on the other hand , expressed increased levels of Fas but low levels of Fas ligand . ^^^ These results are in line with suggestions that the Fas / Fas ligand pathway may trigger the increased levels of apoptosis observed in cells from HIV 1 infected individuals . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Studies on Fas ligand expression in patients with systemic lupus erythematosus ] . ^^^ The Fas / Fas ligand ( FasL ) mediated apoptosis may play a role in the induction and maintenance of T cell tolerance . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It has recently been proposed that induction of Fas ligand ( FasL ) expression with subsequent autocrine and / or paracrine induction of cell death through binding to the Fas ( Apo 1 / CD95 ) membrane accounts for chemotherapy associated apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Sertoli cells produce an immunosuppressant factor , Fas ligand ( Fas L ) , that may provide the testis with its immunoprivileged status . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Animal model studies , using the lpr and gld strains of mice , have identified FAS receptor ( FAS ) and FAS ligand ( FAS L ) as important components of this mechanism . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Unlike activation induced T cell death , it is not inhibited by neutralizing Abs reactive with TNF alpha or Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression is restricted to nonlymphoid thymic components in situ . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of the apoptosis inducing Fas ligand ( FasL ) in human first and third trimester placenta and choriocarcinoma cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Where great progress has been made is in understanding the events occurring after binding of either Fas ligand or tumor necrosis factor to their respective receptors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Functional Fas and Fas ligand activities in activated T cells of kidney transplant recipients . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas Fas ligand based interactions between tumor cells and tumor specific cytotoxic T lymphocytes : a lethal two way street . ^^^ In the current study , we investigated the repercussions of the interaction between tumor cells ( LSA ) and the tumor specific cytotoxic T lymphocyte ( CTL ) ( PE 9 ) when both expressed Fas and Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Reverse transcriptase polymerase chain reaction ( RT PCR ) analysis revealed that STIL 3 C 5 cells , but not STIL 3 DF cells expressed perforin , granzyme A & B , and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cross linking of Fas ( CD 95 , APO 1 ) and Fas ligand ( FasL ; CD95L ) induces apoptosis of Fas bearing cells . ^^^ Trophoblasts express Fas ligand : a proposed mechanism for immune privilege in placenta and maternal invasion . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the testes , testicular germ cell survival is mediated by adjacent Sertoli cells via the Fas ligand ( FasL ) Fas receptor ( Fas ) system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL ) has been shown to be processed by the action of certain metalloproteinase and released from the cell surface . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Only CSA1M cells were lysed by anti Fas mAb or cells expressing Fas ligand ( FasL ) , indicating that Fas on CSA1M cells is functional in mediating cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
T cells with proliferative unresponsiveness were sensitive to Fas mediated apoptosis whether it was triggered by anti Fas mAb or by Fas ligand , but were almost completely resistant to CD 2 apoptotic signaling . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It is shown that the unexpectedly rapid and efficient lysis of bystanders by Ag activated CTL is mediated by a Fas ligand ( FasL ) / Fas based mechanism and does not depend on perforin . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition to these immunosuppressive agents , monoclonal antibodies against functional cell surface molecules , such as LFA 1 , ICAM 1 , Fas , and Fas ligand , must be effective for treatment of TA GVHD . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas antigen ( CD 95 , APO 1 ) is a transmembrane cell surface receptor that mediates apoptosis of many cell types when bound by Fas ligand or cross linked by agonist antibody . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
B cells are susceptible to Fas ligand ( FasL ) + CD 4 ( + ) Th 1 cell mediated apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunosensitization of prostate carcinoma cell lines for lymphocytes ( CTL , TIL , LAK ) mediated apoptosis via the Fas Fas ligand pathway of cytotoxicity . ^^^ Cytotoxic T lymphocytes kill target cells by two main mechanisms , namely by the perforin pathway and by the Fas ligand ( Fas L ) pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
For example , apoptotic death depends on the balance of Fas , Fas ligand , nuclear factors ( such as bcl 2 , bax , and myc ) , cytokines , neuropeptides , and cell membrane interactions with extracellular matrix . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand enhance the pathogenesis of experimental allergic encephalomyelitis , but are not essential for immune privilege in the central nervous system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cyclosporine insensitive partial signaling and multiple roles of Ca2+ in Fas ligand induced lysis . ^^^ The induction of Fas ligand ( FasL ) mRNA expression and FasL mediated cytotoxicity in CD8+ CTL is a rapid and transient response to activation via the TCR . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here , we show that TCR signal in the presence or absence of CD 28 costimulation induced equivalent expression of Fas and Fas ligand . ^^^ Although anergized cells expressed Fas and Fas ligand , they were resistant to Fas AICD . ^^^ In contrast , CD 28 costimulated cells that also expressed Fas and Fas ligand were initially resistant to Fas AICD but became susceptible after 72 h of culture . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
HLA DR triggered inhibition of hemopoiesis involves Fas / Fas ligand interactions and is prevented by c kit ligand . ^^^ The addition of Fas Ig , a fusion protein that neutralizes Fas ligand ( Fas L ) , also prevented mAb H81 . 9 induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Contribution of Fas ligand to T cell mediated hepatic injury in mice . ^^^ METHODS : Fas ligand mediated lysis of primary hepatocytes from C57BL / 6 wild type , Fas ligand deficient gld , and Fas deficient lpr mice and concanavalin A induced hepatitis in these mice were assessed . ^^^ RESULTS : Freshly isolated hepatocytes from wild type or gld mice , but not those from lpr mice , were susceptible to Fas ligand mediated lysis . ^^^ Reverse transcription polymerase chain reaction and flow cytometric analysis showed that Fas ligand was induced in the liver shortly after the concanavalin A injection and was predominantly expressed on intrahepatic T cells . ^^^ Administration of monoclonal antibody neutralizing mouse Fas ligand could reduce the aminotransferase increase . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Role of Fas ligand in conferring immune privilege to non lymphoid cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas ligand virus also inhibited production of interferon gamma by collagen specific T cells . ^^^ Coadministration of Fas immunoglobulin fusion protein with the Fas ligand virus prevented these effects , demonstrating the specificity of the Fas ligand virus . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand interaction is necessary for human osteoblast apoptosis . ^^^ Activated PBMCs expressed Fas ligand ( FasL ) strongly on their surface and killed MG 63 and primary osteoblast like cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Fas ligand expression and induction of apoptosis in chondrocytes . ^^^ OBJECTIVE : To examine the expression of Fas / Fas ligand and the role of this ligand / receptor interaction in the regulation of apoptosis in normal human articular chondrocytes and in osteoarthritis ( OA ) cartilage . ^^^ Fas ligand messenger RNA was not detectable in resting or activated normal or OA chondrocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Protein expression of Fas / APO 1 or bcl 2 , and messenger RNA ( mRNA ) expression of bcl 2 , bcl xL , bax , bak , Fas / APO 1 , Fas ligand ( Fas L ) , c myc , mad , or max were determined . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Proteasome regulation of Fas ligand cytotoxicity . ^^^ When activated by immobilized anti CD 3 monoclonal antibody , hybridoma T cells ( 5D5 ) degraded 1 kappa B beta , translocated NF kappa B into the nucleus , transcribed immediate early genes and the Fas ligand ( FasL ) gene , and expressed FasL mediated cytotoxicity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas ligand induces apoptosis upon binding to Fas / APO 1 ( CD 95 ) bearing target cells . ^^^ Increased expression of functional Fas ligand in activated T cells from patients with systemic lupus erythematosus . ^^^ Activation induced cell death ( AICD ) in T cells is mediated by upregulation of Fas ligand on the cell surface membrane upon crosslinking of the TCR . ^^^ To elucidate possible abnormalities in the process of AICD in human SLE , we studied the expression and function of Fas ligand in polyclonal T cell lines from patients with SLE , patients with other rheumatic diseases and normal controls . ^^^ SLE T cells expressed on their surface significantly higher amounts of Fas ligand compared to the two control groups . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activated T cells undergo apoptosis when the Fas antigen ( Apo 1 , CD 95 ) is ligated by Fas ligand molecules ( FasL ) or agonistic anti Fas antibodies . ^^^ Activation induced T cell death : resistance or susceptibility correlate with cell surface fas ligand expression and T helper phenotype . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The data indicate that MoAb 90 and YTH 862 directed against the alpha 1 domain of HLA class 1 trigger apoptosis of activated T lymphocytes by a pathway which does not involve Fas ligand . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas antigen is a cell surface receptor that , when engaged by Fas ligand or specific agonistic antibodies , triggers apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunofluorescence microscopic and biochemical analyses revealed that , at the early phase of Fas ligand ( FasL ) induced apoptosis in L cells expressing Fas ( LHF ) , ERM proteins translocate from the plasma membranes of microvilli to the cytoplasm concomitant with dephosphorylation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interestingly , CD8+CD45RA+CD27 cells parallel effector CTLs , as they abundantly express Fas ligand mRNA , contain perforin and granzyme B , and have high cytolytic activity without in vitro prestimulation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Significant elevation of Fas ligand mRNA was found in the subset by L 2 particle exposure , while expression of Fas antigen on uninfected T cells was induced by exposure to IFN gamma . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Role of Fas Fas ligand interactions in the immunorejection of allogeneic mouse corneal transplants . ^^^ BACKGROUND : The expression of Fas ligand ( FasL ) in the eye has been proposed to be an important component of ocular immune privilege . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Salem Chouaib and colleagues discuss evidence that , to escape the immune system , tumor cells not only produce immunosuppressive cytokines but also employ strategies involving altered susceptibility to tumor necrosis factor and Fas cytotoxic pathways and , in some circumstances , use of the Fas ligand to neutralize effector cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
AK T cell mediated killing of P 815 tumor cells pre treated with 2 microg / ml cisplatin or 1 microg / ml etoposide was only partially inhibitable by the Ca2+ chelator EGTA , suggesting that the Ca2+ independent Fas ( CD 95 ) / Fas ligand cytolytic pathway of AK T cells contributes to cytotoxicity . ^^^ Taken together , our results demonstrate that short term exposure to concentrations of cisplatin and etoposide in the low cytotoxic range and below up regulates Fas expression by P 815 tumor cells , thereby facilitating cytotoxicity mediated through the Fas / Fas ligand cytolytic pathway . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The amount of cell surface Fas and its ligand increases before the onset of apoptosis and the presence of a Fas ligand antagonizing antibody inhibits apoptosis . ^^^ Since virus infected cells simultaneously express Fas and Fas ligand , it is likely that apoptosis is induced when the cells come into contact with each other . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Since RAP is known to block IL 2 signaling through the IL 2R , we hypothesized that RAP may interfere with CTL generation by inhibiting IL 2 induced expression of granzyme ( Gzm ) B , perforin , and / or Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Impaired peripheral deletion of activated T cells in mice lacking the common cytokine receptor gamma chain : defective Fas ligand expression in gamma chain deficient mice . ^^^ Moreover , these T cells exhibit decreased expression of Fas ligand , suggesting that Fas bearing cells can not be effectively eliminated in vivo in gamma c deficient mice . ^^^ Thus , gamma c dependent signals play a role in peripheral T cell deletion , presumably by inducing Fas ligand on activated T cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interleukin 10 promotes activation induced cell death of SLE lymphocytes mediated by Fas ligand . ^^^ We conclude that the spontaneous cell death observed in vitro in lymphocytes from patients with SLE and other systemic autoimmune disorders results from in vivo T cell activation , is actively induced by IL 10 and Fas ligand , and reflects pathophysiologically important events in vivo . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Fas ligand interaction regulates cytotoxicity of CD4+ T cells against staphylococcal enterotoxin B pulsed endothelial cells . ^^^ After this cocultivation , the cytotoxicity and Fas ligand ( FasL ) expression of CD4+ T cells were examined . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Since the trigger for apoptotic cellular suicide in nonischemic myocardium is unknown , we analyzed in human myocardial tissue the expression of the apoptosis inducing membrane receptor Fas / APO 1 and of its alternatively spliced soluble isoforms which antagonize Fas by binding of the Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Malignant and reactive cells from human lymphomas frequently express Fas ligand but display a different sensitivity to Fas mediated apoptosis . ^^^ Fas ligand ( FasL ) is capable of inducing apoptosis of lymphoid cells by cross linking with its natural receptor , Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand mRNA in germinal centres of the human tonsil . ^^^ Fas ligand ( FasL ) , a cell surface molecule belonging to the tumour necrosis family , induces apoptosis through its receptor , Fas antigen ( Fas ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Competition for Fas ligand or inactivation of the Fas pathway secondary to intracellular mutation ( MOLT 4 T cells ) also had modest effects on overall cell death during acute HIV infection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activated or transformed cells expressing the Fas antigen on their surface are susceptible to killing by immune effector cells that express the Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Both TNF and Fas ligand have been able to induce programmed cell death ( apoptosis ) of cardiomyocytes in various experimental studies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunoreactivity for the Fas ligand in the mammalian enteric nervous system . ^^^ The Fas ligand induces apoptosis in activated immunocytes that express the Fas receptor . ^^^ Fas ligand transcripts have been found previously in murine intestine but the intestinal tissues that express Fas ligand have not been identified . ^^^ We used immunohistochemistry to examine the expression of the Fas ligand in the enteric nervous system of rats , mice , guinea pigs , ferrets and humans . ^^^ Fas ligand immunoreactivity was detectable in enteric nerve fibres and neurons in all species tested , representing 25 % 50 % of the neurons in rats , mice and guinea pigs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CTL apoptosis could be blocked by 50 % when binding of the Fas ligand to its receptor , the CD 95 ( APO 1 / Fas ) molecule , was prevented . ^^^ Fas ligand was detected in the activated T cells , but not in MCF 7 or a panel of other breast cancer cell lines . ^^^ This excludes an active role for MCF 7 during CTL death and indicates that the CTL apoptosis is due to an autocrine production of the Fas ligand by CTLs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
IL 18 accounts for both TNF alpha and Fas ligand mediated hepatotoxic pathways in endotoxin induced liver injury in mice . ^^^ As previously reported , this liver injury can be prevented by treatment with an Ab against IL 18 , a novel cytokine with the ability to induce IFN gamma production and up regulate functional Fas ligand ( FasL ) expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
C57BL / 6 gld / gld ( B6 / gld ) mice have a point mutation in the gene for Fas ligand ( FasL ) resulting in nonfunctional FasL protein . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression and function in systemic lupus erythematosus . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis and Fas / Fas ligand mRNA expression in acute immune complex alveolitis in mice . ^^^ Deoxyribonucleic acid ( DNA ) strand breaks as a characteristic of apoptosis , and Fas antigen ( Fas ) / Fas ligand ( FasL ) expression may participate in acute immune complex alveolitis in mice . ^^^ These results suggest that apoptosis may be associated with the resolution of inflammation and with tissue repair and also suggest the involvement of the Fas antigen / Fas ligand pathway in acute immune complex alveolitis in mice . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Potential for involvement of Fas antigen / Fas ligand interaction in apoptosis of epithelial cells by intraepithelial lymphocytes in murine small intestine . ^^^ To determine whether the Fas antigen ( Fas ) / Fas ligand ( FasL ) system is involved in the mechanism leading to apoptosis of 1 EC , we examined the expression of Fas and FasL on the 1 EC and intestinal intraepithelial lymphocytes ( 1 IEL ) in normal mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Gene transfer of Fas ligand induces tumor regression in vivo . ^^^ The Fas Fas ligand ( FasL ) system plays an important role in the induction of lymphoid apoptosis and has been implicated in the suppression of immune responses . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The decreased clonal deletion of old mice may be related to their decreased expression of Fas ligand or TNF alpha after SEB injection . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Membrane Fas ligand kills human peripheral blood T lymphocytes , and soluble Fas ligand blocks the killing . ^^^ Here , we demonstrate that membrane bound Fas ligand ( FasL ) kills both fresh and in vitro activated PBT , indicating that the Fas expressed on fresh PBT is functional . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Special attention was directed to the roles of Fas ( CD 95 ) Fas ligand ( FasL ) interactions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : With the use of immunohistochemical and in situ apoptotic detection techniques , apoptotic molecules ( Fas or Fas ligand [ FasL ] ) and nuclear DNA fragmentation were examined in 8 enucleated eyes with Behet ' s disease ( 1 ) , sarcoidosis ( 1 ) , subretinal fibrosis and uveitis ( 1 ) , sympathetic ophthalmia ( 4 ) , and the Vogt Koyanagi Harada syndrome ( 1 ) ; in 5 chorioretinal biopsy specimens with acute retinal necrosis ( 2 ) , multifocal choroiditis ( 1 ) , sarcoidosis ( 1 ) , and subretinal fibrosis and uveitis ( 1 ) ; and in 3 normal control eyes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Role of the Fas / Fas ligand pathway in apoptotic cell death induced by the human T cell lymphotropic virus type 1 Tax transactivator . ^^^ In an attempt to detect the cellular genes mediating this effect , it was found that induction of Tax was associated with marked upregulation of the Fas ligand ( FasL ) gene . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
T cell cytotoxicity is primarily mediated by two cell surface proteins , Fas ligand ( FasL ) and tumour necrosis factor related apoptosis inducing ligand ( TRAIL ) , and intracellular perforin and granzyme granules . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The authors have studied the interaction of cytokines and the Fas receptor in the regulation of apoptosis of renal fibroblasts and have observed that murine renal fibroblasts express Fas and the Fas ligand . ^^^ Murine renal fibroblasts express constitutively both fas ligand mRNA and cell surface Fas ligand , but the authors could not demonstrate a role for Fas ligand in the autocrine regulation of fibroblast survival . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Separate domains of the human fas ligand dictate self association and receptor binding . ^^^ The Fas ligand ( FasL ) , a member of the tumor necrosis factor family of ligands , is a 40 kilodalton type 2 transmembrane protein which is cleaved to produce soluble ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand is a potent inducer of apoptosis in human glioma cells by the Fas / Fas ligand pathway . ^^^ To evaluate the involvement of potential components involved in Fas ligand and metalloprotease inhibitor induced apoptosis , we investigated the effect of anti human Fas antibody , soluble Fas ligand and puromycin on cultures of human malignant glioma cell lines ( LN 18 , LN 229 , T98G ) . ^^^ Stimulation with Fas ligand lead to apoptotic cell death within 16 h . ^^^ Costimulation with the translational inhibitor cycloheximide and the transcription blocker actinomycin D did not reduce Fas ligand toxicity . ^^^ Whereas inhibition of caspase activity with the general inhibitor zVAD fmk resulted in a complete block of Fas ligand induced cell death , puromycin mediated apoptosis was found to be unaffected by zVAD fmk as well as by more specific inhibitors for caspase 1 ( Interleukin 1 beta converting enzyme ) and caspase 3 ( CPP32 / Yama ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Allogeneic transplantation of islets of Langerhans was facilitated by the cotransplantation of syngeneic myoblasts genetically engineered to express the Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The protein expressions of p 53 and Fas ligand by KG 1 cells , which constitutively express the Fas antigen ( CD 95 ) , were found to increase after exposure to IL 18 for 20 hours . ^^^ Interleukin 18 enhances Fas ligand expression and induces apoptosis in Fas expressing human myelomonocytic KG 1 cells . ^^^ Both Fas ligand and its receptor were found to be functional by in vitro assays on Fas expressing target cells and an agonist anti Fas antibody , respectively . ^^^ In conclusion , IL 18 enhances the expression of Fas ligand by Fas expressing KG 1 cells and induces apoptosis in the cells through a mechanism probably involving the Fas pathway . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Detectable concentrations of Fas ligand in cerebrospinal fluid after severe head injury . ^^^ When the cell surface molecule Fas is triggered by its agonist Fas ligand the result is apoptosis of these cells and tissue destruction . ^^^ To elucidate the pathophysiological relevance of Fas ligand in patients with cerebral oedema caused by trauma , we examined its concentrations in cerebrospinal fluid in 18 patients using specific ELISA . ^^^ Serum and cerebrospinal fluid from healthy people and injured patients without head trauma did not contain detectable Fas ligand . ^^^ In contrast , cerebrospinal fluid from patients with severe brain injury contained high concentrations of Fas ligand without detectable concentrations in serum . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Later development of Fas ligand mediated cytotoxicity as compared with granule mediated cytotoxicity during the maturation of natural killer cells . ^^^ Fas ligand ( FasL ) mRNA was expressed in freshly isolated CD2+ NK cells but not in the CD 2 NK cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Lack of tissue expression of Fas ligand in the fetal grafts suggests that the latter does not contribute to the delayed rejection of human fetal kidneys . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Nasal T / NK cell lymphomas commonly express perforin and Fas ligand : important mediators of tissue damage . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Maximal proliferation of cytotoxic T lymphocytes requires reverse signaling through Fas ligand . ^^^ Fas ligand ( FasL / CD95L ) is best known for its role in delivering apoptotic signals through its receptor , Fas ( APO 1 / CD95 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
When neuronally differentiated rat pheochromocytoma PC 12 cells deprived of nerve growth factor and serum , mouse mast cells deprived of hematopoietic cytokines or human monocytic U 937 cells stimulated via Fas antigen ( a receptor for the death factor Fas ligand ) , were exposed to type 2 sPLA 2 at concentrations comparable to those detected at inflamed sites , the release of arachidonic acid was significantly accelerated in association with the process of programmed cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We report here that in contrast to keratinocytes in normal skin ( n = 4 ) , BCC tumor cells ( n = 6 ) strongly and diffusely express Fas ligand ( CD95L ) , but not Fas antigen ( CD 95 ) . ^^^ Sunlight induced basal cell carcinoma tumor cells and ultraviolet B irradiated psoriatic plaques express Fas ligand ( CD95L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas receptor ( APO 1 / CD95 ) is expressed on hepatocytes and is thought to be important in triggering apoptosis after ligation by the Fas ligand carried on cytotoxic T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Downregulation of Fas ligand by shedding . ^^^ Apoptosis inducing Fas ligand ( FasL ) is a type 2 membrane protein , predominantly expressed in the activated T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand caught between Scylla and Charybdis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas and Fas ligand in the testes and testicular germ cell tumors : an immunohistochemical study . ^^^ The Fas Fas ligand system plays a crucial role in the production of a signal for apoptosis in the immune system . ^^^ In the present study , expression of Fas and Fas ligand in the testes and testicular germ cell tumors was examined immunohistochemically . ^^^ Expression of both Fas and Fas ligand was found on Leydig cells , Sertoli cells , and germ cells in the testis , and on epithelial cells in the epidydimal duct . ^^^ Expression of both Fas and Fas ligand was also found in all 23 seminomas , 8 embryonal carcinomas , and 3 yolk sac tumors which were examined in this study . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Special attention was directed to the roles of Fas ( CD 95 ) Fas ligand ( FasL ) interactions and CD 40 CD40 ligand ( CD40L ) interactions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This antiapoptotic effect correlates with inhibition of Fas and Fas ligand expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The objectives of this study were to ( 1 ) determine whether Fas antigen , Fas ligand , p 53 , and proto oncogene mRNAs may be detected in lacrimal and submandibular glands of the MRL / lpr mouse model of Sjgren ' s syndrome , and ( 2 ) examine whether gender and androgen or cyclophosphamide therapy influence the mRNA expression of these apoptotic factors . ^^^ Our results demonstrated that ( 1 ) Fas antigen ( exons 1 > 2 or 3 > 7+ ) , Fas ligand , c myb , c myc , bcl 2 , Bax , p 53 , and androgen receptor ( AR ) mRNAs are present in exocrine tissues of MRL / lpr mice ; ( 2 ) the amounts of c myb , c myc , bcl 2 , p 53 , and AR mRNA are higher ( P < 0 . 05 ) and the level of Fas antigen ( exons 1 > 2 ) mRNA is lower ( P < 0 . 05 ) in lacrimal glands of female compared to male mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Why do defects in the Fas Fas ligand system cause autoimmunity . ^^^ We have previously isolated genes that encode Fas and Fas ligand , a receptor ligand pair that mediates an apoptotic signal . ^^^ We also have demonstrated that lpr and gld mice , well known animal models of autoimmune disease are loss of function mutants of the Fas and Fas ligand genes , respectively . ^^^ These findings indicate that the Fas Fas ligand system plays an important role in the maintenance of self tolerance among both humans and mice . ^^^ In contrast , among the lymphocyte subsets , only activated T cells and natural killer cells express readily detectable levels of Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Active cell death induced by ligation of the Fas antigen ( Fas Ag ) with its antibody , Fas ligand ( Fas L ) , has been known to play a major role in cell killing via apoptosis by cytotoxic T lymphocytes ( CTL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand gene transfer to the vessel wall inhibits neointima formation and overrides the adenovirus mediated T cell response . ^^^ Fas ligand ( FasL ) induces apoptosis in Fas bearing cells , and its expression on activated T cells contributes to the regulation of the immune response and physiological cell turnover . ^^^ These data demonstrate that Fas ligand gene transfer can effectively inhibit injury induced vessel lesion formation and can allow adenovirus harboring cells to evade immune destruction . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand mediated killing by intestinal intraepithelial lymphocytes . ^^^ Here , we demonstrate that the IEL isolated from normal mice readily display potent Fas ligand ( FasL ) mediated killing activity after CD 3 stimulation , and that IEC express Fas , suggesting that IEC are potential targets for FasL mediated killing by IEL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here we describe altered ligands for mature mouse CD 4 ( + ) T helper 1 cells that lead to T cell apoptosis by the selective expression of Fas ligand ( FasL ) and tumor necrosis factor ( TNF ) without concomitant IL 2 , IL 3 , or interferon gamma production . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It has been suggested that Fas ligand Fas receptor interactions are involved in the regulation of eosinophil apoptosis and that dysfunctions in this system could contribute to the accumulation of these cells in allergic and asthmatic diseases . ^^^ Therefore , NO concentrations within allergic inflammatory sites may be important in determining whether an eosinophil survives or undergoes apoptosis upon Fas ligand stimulation . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Upregulation of Fas / Fas ligand in inclusion body myositis . ^^^ In this study we have investigated the expression of Fas and Fas ligand in muscle in five patients with inclusion body myositis . ^^^ Reverse transcription polymerase chain reaction showed upregulation of both Fas and Fas ligand in all inclusion body myositis patients . ^^^ Immunohistochemical investigation showed expression of Fas ligand in many of the muscle infiltrating mononuclear cells . ^^^ The results indicate that the Fas / Fas ligand system may be of importance for the inflammatory reaction and T cell mediated muscle cell injury . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Primary CLL cells underwent spontaneous apoptosis in culture , which was enhanced by exogenous human Fas ligand ( FasL ) or fludarabine . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We have investigated the role of interleukin 6 ( IL 6 ) in the induction of major histocompatibility complex ( MHC ) unrestricted cytotoxicity , as well as granzyme B , perforin , and Fas ligand gene expression , following mouse T lymphocyte activation with anti CD 3 monoclonal antibody ( mAb ) . ^^^ In addition , IL 6 neutralization resulted in decreased expression of granzyme B and perforin , but not Fas ligand , mRNA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Because the cell surface receptor known as Fas ( APO 1 ; CD 95 ) triggers programmed cell death after activation by its ligand and because incubation of human ECFCs with IFNgamma produces apoptosis , we have investigated the expression and function of Fas and Fas ligand ( FasL ) in highly purified human ECFCs before and after incubation with IFNgamma in vitro . ^^^ Fas ligand is present in human erythroid colony forming cells and interacts with Fas induced by interferon gamma to produce erythroid cell apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased mucosal B lymphocyte apoptosis during polymicrobial sepsis is a Fas ligand but not an endotoxin mediated process . ^^^ Furthermore , we found that Peyer ' s patch lymphocytes isolated from C3H / HeJ Faslgld ( endotoxin tolerant / Fas ligand [ FasL ] deficient ) as opposed to C3H / HeJ ( endotoxin tolerant ) inbred mice did not exhibit increased Ao after CLP . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The mechanism by which they mediate their anti tumor effects remains unclear , and some studies have suggested that Fas ligand ( FasL ) / Fas interactions were involved . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The interaction of the cell membrance protein , Fas , with its ligand , Fas ligand , induces apoptosis in Fas bearing cells . ^^^ Although studies in the transplanted hearts of rodents and humans have shown the presence of Fas , Fas ligand , and apoptosis in the myocardium , there is controversy regarding which cells in the myocardium are actually undergoing apoptosis after heart transplantation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand gene transfer to renal allografts in rats : effects on allograft survival . ^^^ BACKGROUND : Fas ligand ( FasL ) induces apoptosis of cells bearing its receptor Fas , and has been shown to be important in T cell development and regulation and in immune privilege . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand is a specific death factor that induces apoptosis by binding to its receptor Fas . ^^^ Expression of Fas ligand in tumor cells resistant to Fas mediated apoptosis helps the tumor to escape surveillance by the immune system . ^^^ Inducing apoptosis in the attacking lymphocytes resembles the mechanism of how Fas ligand contributes to the maintenance of immune privilege . ^^^ Some cytostatic drugs used in chemotherapy kill their target cells by upregulating expression of Fas and inducing Fas ligand expression in the same cell by different mechanisms . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis in the cornea : further characterization of Fas / Fas ligand system . ^^^ This study was performed to further characterize expression and function of the Fas / Fas ligand system in the cornea . ^^^ Specifically , these experiments examined ( 1 ) the effect of genetic inactivation of Fas or Fas ligand genes on keratocyte apoptosis in response to corneal epithelial wounding , ( 2 ) whether cultured human corneal epithelial and endothelial cells are competent to undergo apoptosis in response to Fas activation , ( 3 ) expression of membrane bound and soluble Fas and Fas ligand in corneal cells , and ( 4 ) the effect of IL 1 on expression of Fas and Fas ligand in corneal fibroblasts . ^^^ Keratocyte apoptosis in response to corneal epithelial scrape detected by TUNEL assay and transmission electron microscopy was significantly decreased , but not eliminated , in Fas ligand / mice compared with control + / + mice . ^^^ Thus , while the Fas / Fas ligand system is likely involved in regulating keratocyte apoptosis in response to epithelial wounding , systems with redundant function probably also modulate this response . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These findings also suggest that CD 40 signaling provides a switch which renders the cells susceptible to Fas ligand mediated apoptosis through up regulation of Fas whilst affording protection from anti Ig induced apoptosis through up regulation of Bcl xL . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas antigen ( Fas ) is a cell surface receptor molecule that mediates apoptosis inducing signals into activated and / or autoreactive peripheral T and B cells by stimulation with Fas ligand or agonistic anti Fas mAb . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Evidence for tight coupling of gonadotropin releasing hormone receptor to stimulated Fas ligand expression in reproductive tract tumors : possible mechanism for hormonal control of apoptotic cell death . ^^^ Fas ligand induces cell death by means of apoptosis in a variety of cell types when cross linked with its natural receptor , Fas . ^^^ To provide a potential association of the Fas system with the antiproliferative signaling process of GnRH receptor , we have evaluated the regulation of Fas ligand expression in GnRH receptor positive tumors and cloned cell lines known to have substantial GnRH receptors . ^^^ Fas ligand protein was characterized by immunoblotting of membrane proteins with the specific antibody . ^^^ Fas ligand messenger RNA was determined by RT PCR using oligonucleotide primers synthesized according to the published Fas ligand sequence . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Lack of evidence for expression of Fas ligand in Fas bearing tumors . ^^^ We recently demonstrated the frequent expression of Fas in female reproductive tract tumors , which prompted us to examine the local production of Fas ligand by the Fas bearing tumors . ^^^ No expression of Fas ligand messenger ribonucleic acid ( mRNA ) as assessed by reverse transcription polymerase chain reaction using oligonucleotide primers according to published sequences were observed ; Fas ligand mRNA was detected in lymphocytes . ^^^ Immunoblotting of membrane proteins with the specific antibody failed to demonstrate any substantial level of immunoreactive Fas ligand in these tumors . ^^^ The results for both mRNA expression and immunoreactivity suggest that human ovarian and endometrial carcinomas lack the Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Malignant NK cells constitutively express Fas ligand ( L ) , both membrane bound ( m ) and soluble ( s ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased apoptosis of T cell subsets in aging humans : altered expression of Fas ( CD 95 ) , Fas ligand , Bcl 2 , and Bax . ^^^ An increased expression of Fas and Fas ligand and a decreased expression of Bcl 2 were observed in both CD4+ and CD8+ T cells from aging as compared with young controls . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
For this purpose , HBeAg Tg mice were bred with Fas and Fas ligand ( FasL ) defective lpr / lpr and gld / gld mutant mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Upon Fc epsilonRI stimulation , basophils , but not mast cells , secreted significant amounts of immunoreactive IL 4 and IL 13 and expressed detectable CD 40 ligand ( CD40L ) and a very low level of Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These findings indicate that cytokine ( s ) plus anti Fas antibody ( which mimics natural Fas ligand ) are more effective in inducing apoptosis of COLO 201 than cytokine ( s ) alone . ^^^ These findings suggest that immunotherapy in combination with cytokine ( s ) and lymphokine activated killer ( LAK ) cells will become a more effective therapy for cancer than cytokine ( s ) or LAK cells alone , since the Fas ligand is expressed on activated T cells , natural killer cells and macrophages . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Analysis of apoptosis associated genes : Fas ligand , bcl 2 and bax in the rat liver allograft . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This process is mediated by Fas / Fas ligand interaction and related to an increased induction of Fas ligand mRNA by gpl 20 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 ( Fas / Apo 1 ) belongs to the TNF receptor superfamily and may mediate apoptosis if triggered by Fas ligand or specific antibodies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
One is pore formation on target cell membrane by perforin secreted from CTLs ( perforin granzyme pathway ) , and the other is ligation of Fas , which is expressed on the surface of target cells and Fas ligand , on the surface of CTLs ( Fas FasL pathway ) ( 2 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 4 regulates susceptibility to Fas ligand and tumor necrosis factor mediated apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The observation showing that administration of exogenous recombinant Fas ligand ( FasL ) to FasL deficient mice resulted in the resolution of cutaneous lesions demonstrates the importance of the Fas FasL pathway in the elimination of parasites . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The CTL clone carries Fas molecules , but failed to express Fas ligand ( FasL ) even after the cross linking of both NKB 1 and CD 3 molecules . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The purpose of this study was to determine whether apoptosis was involved in the evolution of these changes , what cell types are involved , and whether there was an association with the Fas antigen ( Fas or CD 95 ) and Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interaction of the adenovirus 14 . 7 kDa protein with FLICE inhibits Fas ligand induced apoptosis . ^^^ In this report , we demonstrate that infection of cells with an adenovirus vector expressing Fas ligand induced rapid apoptosis that was blocked by coinfection with a virus expressing 14 . 7K . ^^^ Cell death induced by the overexpression of Fas ligand , Fas associated death domain containing protein ( FADD ) / MORT1 , or FADD like interleukin 1beta converting enzyme ( FLICE ) / caspase 8 in a virus free system was efficiently blocked by 14 . 7K expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas / Fas ligand pathway and Bcl 2 regulate T cell responses to model self and foreign antigens . ^^^ We have examined the role of Fas and Bcl 2 in T cell survival and responses to antigen in vivo using T cells that express a transgenic antigen receptor specific for hen egg lysozyme ( HEL ) and that either lack functional Fas or Fas ligand ( FasL ) or overexpress Bcl 2 as a transgene . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although the pathways through which chemotherapeutics promote cell death remain largely unknown , caspase proteases play a central role in the induction of apoptosis in response to a variety of stimuli including tumor necrosis factor , fas ligand , and growth factor deprivation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Human vascular endothelial cells play a pivotal role in atherosclerotic changes but are resistant to apoptotic inducers such as Fas ligand and it has been difficult to induce apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Application of a Fas ligand encoding a recombinant adenovirus vector for prolongation of transgene expression . ^^^ An adenovirus vector encoding murine Fas ligand ( mFasL ) under an inducible control was derived . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
An essential role for Fas ligand in transplantation tolerance induced by donor bone marrow . ^^^ Here we examined a well established adult mouse model of antithymocyte globulin and DBM treatment and show that expression of functional Fas ligand ( FasL , also CD95L ) on the injected bone marrow cells is required for tolerance induction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand expression on human peripheral blood leukocytes . ^^^ OBJECTIVES : Study of Fas and Fas ligand ( Fas L ) expression , as well as sFas L release , by fresh human peripheral blood leukocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here , a summary of the most recent results concerning the protective activity of this family of proteins against programmed cell death is presented . ( 1 ) sHsp enhance the survival of cells exposed to oxidative stress , a phenomenon which is linked to the ability of these proteins to decrease the intracellular level of reactive oxygen species in a glutathione dependent way . ( 2 ) sHsp protect against apoptosis mediated by different agents including staurosporine , etoposide and the Fas ligand . ( 3 ) An interesting and particular aspect of sHsp concerns their transient expression during the cell division to differentiation transition . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas ( APO 1 , CD 95 ) and soluble Fas ligand in rheumatic diseases . ^^^ OBJECTIVE : To assess levels of soluble Fas ( sFas ) and soluble Fas ligand ( sFas L ) in sera from patients with various rheumatic diseases : systemic lupus erythematosus ( SLE ) , rheumatoid arthritis ( RA ) , systemic sclerosis ( SSc ) , polymyositis / dermatomyositis ( PM / DM ) , mixed connective tissue disease ( MCTD ) , and Sjogren ' s syndrome ( SS ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To investigate the mechanism ( s ) underlying CTL damage to the myocardium through activation of the Fas receptor ( Fas / CD95 / Apo 1 ) by the Fas ligand , we explored the interaction between peritoneal exudate CTLs ( PELs ) , derived from perforin gene knockout ( P / ) mice , and murine ventricular myocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The role of Fas ligand in the development of insulitis in nonobese diabetic mice . ^^^ The role of Fas ligand induced lymphocyte apoptosis in the development of insulitis was studied in nonobese diabetic ( NOD ) mice . ^^^ Fas ligand with a molecular weight of 45 kD appeared in the pancreas of NOD mice during the onset of insulitis as demonstrated by western blot analysis . ^^^ Neutralizing Fas ligand antibodies affected 3H thymidine incorporation of CD3+CD28+ pancreatic lymphocytes from 12 to 30 week old NOD mice in one of three cultures . ^^^ There was no difference in the effect of neutralizing Fas ligand antibodies between pancreatic and blood lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
They also trigger surface Fas ( Apo 1 , CD 95 ) expression in naive T cells and Fas ligand gene and protein expression in both naive and primed T cells , resulting in Fas / Fas L interaction mediated cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This report analyzes the gene expression of bcl xs , bcl xl , bax alpha , bax beta , fadd , fas , fas ligand ( fas L ) , ice , TNF alpha , TNF beta , TNFR 1 , TNFR 2 , TRAF 1 , TRAF 2 , TRAF 3 , cIAP 2 , and tradd at the level of mRNA in the single Reed Sternberg cells and their variants . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas is a cell surface molecule that transduces the apoptotic death signaling on the stimulation of Fas ligand , and plays the dominant role in various disease states . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
While ceramide has been shown to be an important regulatory component of apoptosis induced by tumor necrosis factor alpha and the Fas ligand , sphingosine 1 phosphate ( SPP ) , a further metabolite of ceramide , has been implicated as a second messenger in cellular proliferation and survival induced by platelet derived growth factor , neuronal growth factor , and serum . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The roles of Fas , Fas ligand and Bcl 2 in T cell apoptosis in the central nervous system in experimental autoimmune encephalomyelitis . ^^^ Throughout the course of the disease , which peaked 12 14 days after inoculation and was followed by clinical recovery , we analyzed the DNA content of the spinal cord inflammatory cells to assess apoptosis and , simultaneously , we measured the expression of five proteins ( Fas , Fas ligand ( Fas L ) , Bcl 2 , Bcl 10 and Bax ) which modulate the apoptotic process . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activated PBMC expressing membrane type Fas ligand ( mFasL ) efficiently killed both MG 63 and primary osteoblasts like cells , and the addition of human Fas chimeric protein ( hFas Fc ) significantly diminished the cytotoxicity , indicating that interactions between mFasL of activated PBMC and Fas on human osteoblasts induce apoptosis of the latter . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Airway epithelial Fas ligand expression : potential role in modulating bronchial inflammation . ^^^ Epithelium derived Fas ligand is believed to modulate inflammation within various tissues . ^^^ In this paper , we report findings that suggest a similar immunoregulatory role for Fas ligand in the lung . ^^^ First , Fas ligand was localized to nonciliated , cuboidal airway epithelial cells ( Clara cells ) throughout the airways in the normal murine lung by employing nonisotopic in situ hybridization and immunohistochemistry . ^^^ Second , gld mutant mice , which express a dysfunctional Fas ligand protein , were noted to develop prominent infiltration of inflammatory cells in submucosal and peribronchial regions of the upper and lower airways . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Prolongation of allograft survival of transfected islets expressing human CTLA 4 Ig , human soluble Fas ligand or a combination of the two . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression on islets as well as multiple cell lines results in accelerated neutrophilic rejection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Effect of gene gun mediated CTLA4IG and Fas ligand gene transfection on concordant xenogeneic islet graft rejection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Analysis of the NF kappa B p 65 subunit , Fas antigen , Fas ligand and Bcl 2 related proteins in the synovium of RA and polyarticular JRA . ^^^ OBJECTIVE : To investigate the nuclear localization of the transcription factor NF kappa B , the status of apoptosis and the expression of the Fas antigen , Fas ligand , Bcl 2 , Bcl xL and Bax by synovial cells . ^^^ Fas antigen and Fas ligand ( L ) are expressed on up to 90 % and 11 % of CD3+ synovial fluid ( SF ) cells , respectively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ligation of the fas receptor by fas ligand or by agonist antibodies induces apoptotic cell death in most fas expressing cells . ^^^ The fetal central nervous system cells did not express fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here , Ruggero De Maria and Roberto Testi propose that Fas ligand may represent a common weapon during the destructive phase of organ specific autoimmunity . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Protection of islet allografts transplanted together with Fas ligand expressing testicular allografts . ^^^ Fas ligand ( FasL ) is highly expressed in testicular tissues and thought to be responsible for protection from allograft rejection by inducing apoptosis of anti graft activated T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Death of solid tumor cells induced by Fas ligand expressing primary myoblasts . ^^^ Fas ligand ( FasL ) has been reported to be cytotoxic to a variety of cells , including certain tumor cell lines . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Co expression of Fas and Fas ligand in malignant glial tumors and cell lines . ^^^ Fas ligand ( FasL ) is involved in tumor evasion from the immune system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TNFalpha regulation of Fas ligand expression on the vascular endothelium modulates leukocyte extravasation . ^^^ Here , we report that Fas ligand ( FasL ) is expressed on vascular endothelial cells ( ECs ) and that it may function to actively inhibit leukocyte extravasation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Acquisition of granzyme B and Fas ligand proteins by human keratinocytes contributes to epidermal cell defense . ^^^ During an immune response , injured cells are eliminated by cytotoxic lymphoid cells that produce perforin , granzyme B , and Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ligation of cell surface CD 4 inhibits activation induced death of human T lymphocytes at the level of Fas ligand expression . ^^^ In susceptible clones , CD 4 ligation prevented the up regulation of Fas ligand mRNA and cell surface expression in response to anti CD 3 mAb or superantigen stimulation . ^^^ The inhibition of AICD due to the prevention of Fas ligand upregulation reveals a novel immunoregulatory consequence of CD 4 ligation that might play a role in HIV infection and in the therapeutic application of anti CD 4 mAb . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas ligand in the joints of patients with rheumatoid arthritis and osteoarthritis . ^^^ OBJECTIVE : To investigate the expression and function of Fas ligand ( FasL ) , which can be in a membrane bound or soluble form , in the joints of patients with rheumatoid arthritis ( RA ) and osteoarthritis ( OA ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Moreover , although activated CD 8 cells that express Fas ligand and Fas eliminate CD 4 cells through a Fas dependent mechanism , they are themselves resistant to Fas dependent apoptosis . ^^^ These findings indicate a fundamental difference between the two major T cell subsets with regard to sensitivity to Fas dependent apoptosis , expression of Fas ligand , and mediation of suppressive activity following immunization with superantigen . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The c Jun N terminal kinase cascade plays a role in stress induced apoptosis in Jurkat cells by up regulating Fas ligand expression . ^^^ Moreover , DA MEKK 1 induced Fas ligand ( FasL ) cell surface and mRNA expression , as well as FasL promoter activation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand and tumor necrosis factor alpha ( TNF ) bind to members of the TNF receptor superfamily . ^^^ Stimulation by Fas ligand results in apoptosis , whereas TNF induces multiple effects including proliferation , differentiation , and apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Localization of Fas and Fas ligand in bone marrow cells demonstrating myelodysplasia . ^^^ To elucidate the mechanism of apoptosis in bone marrow cells of MDS , the expression of Fas antigen and Fas ligand ( FasL ) was examined by RT PCR and immunohistochemistry . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cytotoxic T cells can kill infected cells by two main mechanisms : the secretion of the pore forming protein perforin or the interaction of the Fas ligand with the apoptosis inducing Fas molecule on the target cell . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Reverse transcriptase PCR analyses determined there were similar levels of transcripts for Fas , Fas ligand , perforin , and granzyme B in control and CD 8 depleted allograft recipients . ^^^ By Western blot it was determined that the levels of Fas ligand protein were increased in the CD 8 depleted group compared with those in control and FK 506 treated allograft recipients . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Fas ligand signaling during gestational T cell development . ^^^ Most thymocytes express high levels of Fas Ag ( Apo 1 / CD95 ) ; however , the role of Fas / Fas ligand mediated apoptosis in thymocyte development remains unclear . ^^^ During gestational development of thymocytes in C57BL / 6 ( B 6 ) + / + mice , the highest levels of Fas ligand mRNA and Fas ligand protein expression were detected at gestational day ( GD ) 15 , and there was a ninefold decrease in Fas ligand mRNA expression between GD 15 and 17 accompanied by a sixfold increase in Fas mRNA . ^^^ Thus , early apoptosis correlated with high expression of Fas ligand . ^^^ High levels of Fas ligand mRNA were maintained throughout gestational development in thymocytes of Fas deficient B 6 lpr / lpr mice , but cortical clusters and scattered apoptotic cells were decreased relative to B 6 + / + mice before GD 17 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Binding of Fas ligand to Fas induces apoptosis in Fas bearing cells . ^^^ These results suggest that autoreactive or activated B cells must be killed through Fas expressed in the B cells by the Fas ligand expressed in activated T cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Disparate roles for TNF alpha and Fas ligand in concanavalin A induced hepatitis . ^^^ In acute inflammation , however , apoptosis triggered by the overproduction of `` death factors ' ' such as TNF alpha or Fas ligand ( FasL ) may contribute to tissue injury . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Previously , we have shown that PS 2 , a homolog of PS 1 . regulates apoptosis induced in neurons by trophic withdrawal or Abeta , and in T cells by Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The proteins encoded by these genes could confer the capacity to degrade macromolecular components of the extracellular matrix ( ECM ) , and to shed transmembrane proteins such as tumor necrosis factor ( TNF ) , TNF receptor , Interleukin 6 receptor and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas system , comprising the Fas receptor ( Fas , CD 95 , APO 1 ) and its ligand , Fas ligand ( FasL ) , is a central mediator of programmed cell death in various physiological and pathological processes . ^^^ Human pancreatic adenocarcinomas express Fas and Fas ligand yet are resistant to Fas mediated apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas Fas ligand system associated with atresia in murine ovary . ^^^ We detected that Fas receptor ( Fas ) was expressed at transcriptional levels in oocytes / eggs and some granulosa cells of murine ovary , whereas , Fas ligand ( FasL ) was found to be strongly expressed in granulosa cells by means of in situ hybridisation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The recent characterization of members of the tumor necrosis factor alpha gene family has identified ligands ( Fas ligand and TRAIL ) and corresponding death receptors ( DR ) . ^^^ Conversely , high level expression of Fas ligand on the allograft correlates with graft acceptance in some models of organ transplantation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activation induced NK cell death triggered by CD 2 ligation is extremely rapid ( DNA fragmentation is first observed at 90 min ) and it is not inhibited by neutralizing antibodies reactive with TNF alpha or Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Up regulation of Fas ligand ( FasL ) mRNA expression in peripheral blood mononuclear cells ( PBMC ) after major surgery . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 antigen ( also known as Fas or Apo 1 ) and Fas ligand play key roles in apoptosis of cells of the immune system , function as effector molecules of cytotoxic T lymphocytes , and function in the elimination of activated lymphocytes during the downregulation of the immune response . ^^^ CD 95 antigen ( also known as Fas or Apo 1 ) and Fas ligand play key roles in apoptosis of cells of the immune system , function as effector molecules of cytotoxic T lymphocytes , and function in the elimination of activated lymphocytes during the downregulation of the immune response . ^^^ The critical roles of the Fas Fas ligand system in apoptosis suggest that its inactivation may be involved in malignant transformation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Technical note : Aberrant detection of cell surface Fas ligand with anti peptide antibodies . ^^^ Polyclonal rabbit Abs raised against peptides from the C terminal region ( the extracellular domain ) of human Fas ligand were produced for the detection of the molecule in Western blot analysis and immunohistochemistry . ^^^ These Abs have been used by several groups of investigators to assess cell surface Fas ligand via flow cytometry , but we show that these polyclonal rabbit Abs do not detect cell surface Fas ligand by that technique . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We show here that the apoptosis related surface Ag Fas ( APO 1 , CD 95 ) and its ligand , Fas ligand ( FasL ) are critically involved , since Fas deficient lpr mice and FasL deficient gld mice do not develop UV induced tolerance . ^^^ Ultraviolet light induced immune tolerance is mediated via the Fas / Fas ligand system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Induction of Fas ligand in murine bone marrow NK cells by bacterial polysaccharides . ^^^ The LPS or mannuronan induced cytotoxicity was due to increased Fas ligand ( FasL ) expression by BMC , since 1 ) Fas transfected L 1210 Fas target cells were more susceptible to lysis than the Fas ( low ) expressing parent L 1210 cells , 2 ) stimulated BMC from FasL defective gld / gld mice were not cytolytic and , 3 ) the cytolytic activity of normal BMC was inhibited by a Fas Fc fusion protein . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of RICK promoted the activation of caspase 8 and potentiated apoptosis induced by Fas ligand , FADD , CLARP , and caspase 8 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Indeed , the cytotoxic index obtained by alpha GalCer activated Valpha 14 NKT cells was reduced by the addition of cold target tumor cells or by treatment with concanamycin A , which inhibits activation and secretion of perforin , but not by mAbs against molecules involved in the NKT cell recognition and conventional cytotoxicity , such as CD1d , Vbeta 8 , NK 1 . 1 , Ly49C , Fas , or Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression in nodal non Hodgkin ' s lymphoma . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In order to investigate the involvement of apoptosis in the pathogenesis of aplastic anaemia ( AA ) we measured the expression of the Fas receptor ( membrane protein that triggers apoptosis ) , Fas ligand ( FasL ) , bcl 2 ( cytoplasmatic protein that blocks apoptosis ) and p 53 ( nuclear protein that induces apoptosis ) in CD 3 and CD 19 lymphocytes from the peripheral blood or bone marrow of controls , patients with AA , aplastic anaemia in complete remission ( AA CR ) and multiply transfused patients without aplastic anaemia . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Toso appeared limited to inhibition of apoptosis mediated by members of the TNF receptor family and was capable of inhibiting T cell self killing induced by TCR activation processes that up regulate Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin 1beta and Fas ligation . ^^^ Western blotting and immunocytochemistry clearly show for the first time that human pancreatic beta cells normally express Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In order to investigate the possible involvement of apoptosis in the pathogenesis of thyroid associated ophthalmopathy ( TAO ) , we studied the expression of Fas , Fas ligand ( FasL ) , and Bcl 2 in extraocular muscle tissues from patients with TAO by immunohistochemistry using monoclonal antibodies against Fas , FasL , and Bcl 2 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We also performed immunostaining for Fas and Fas ligand ( Fas L ) to determine the relationship between the Fas system and apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Sho saiko to induced apoptotic cell death of Mel ret cells with a definite increase of cell surface Fas antigen and Fas ligand ( FasL ) . ^^^ Ingredient analysis revealed that baicalin is likely the main active constituent in the upregulation of Fas antigen and Fas ligand , while glycyrrhizin is the main constituent in the inhibition of cdks . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Differential effects of anti Fas ligand and anti tumor necrosis factor alpha antibodies on acute graft versus host disease pathologies . ^^^ Both tumor necrosis factor alpha ( TNFalpha ) and Fas ligand ( FasL ) have been implicated in the pathogenesis of graft versus host disease ( GVHD ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The B CLL cell line EHEB as well as CD 19 ( + ) cells from B CLL patients constitutively expressed Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Enhanced expression of Fas ligand is associated with aburatubolactam C induced apoptosis in human Jurkat T cells . ^^^ When the cells were treated with 3 micrograms / ml of aburatubolactam C , apoptotic DNA fragmentation was first detectable in 3 hr and then increased time dependently in accordance with upregulation in the protein level of Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Granulosa cell apoptosis induced at the penultimate stage of follicular development is associated with increased levels of Fas and Fas ligand in the rat ovary . ^^^ We therefore investigated the possible role of the cytokine Fas ligand ( FasL ) and its receptor Fas in apoptosis during ovarian follicular atresia induced by gonadotropin withdrawal . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Three color flow cytometry in MBP treated rats demonstrated that CNS Vbeta8 . 2+ T cells expressing Fas ( CD 95 ) and Fas ligand were highly vulnerable to apoptosis compared to Vbeta8 . 2+ Tcells not expressing these proteins . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Of the target cells tested , Fas was only expressed on Con A blasts , indicating that Fas ligand ( FasL ) dependent cytotoxicity is limited to such cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Autocrine and paracrine apoptosis are mediated by differential regulation of Fas ligand activity in two distinct Jurkat T cell populations . ^^^ Fas ligand ( FasL ) produced by activated T cells mediates autocrine induced apoptosis to limit T cell expansion . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand induced apoptosis of infected human macrophages reduces the viability of intracellular Mycobacterium tuberculosis . ^^^ We have examined the effect of Fas ligand ( FasL ) induced apoptosis of human macrophages infected in vitro with M . tuberculosis on the viability of the intracellular bacilli . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It also enhanced the mRNA expression of TNF alpha , Fas ligand , and cytokine inducible nitric oxide synthase . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas counterattack in vivo : apoptotic depletion of tumor infiltrating lymphocytes associated with Fas ligand expression by human esophageal carcinoma . ^^^ Various cancer cell lines express Fas ligand ( FasL ) and can kill lymphoid cells by Fas mediated apoptosis in vitro . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( APO 1 / CD95 ) is a cell surface receptor that mediates apoptosis when it reacts with Fas ligand ( FasL ) or Fas antibody . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The functional expression of Fas ligand on tumor cells reported in a variety of neoplasms has been proposed by several groups as a mechanism of tumor escape from immunological detection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We now recognize that TNF alpha is a member of a large family of proteins , including Fas ligand , whose actions are primarily paracrine in nature , and serve to regulate both cell proliferation and apoptotic death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expressed in activated T cells binds to its receptor , Fas , and induces apoptosis in target cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Kinetics of expression and subset distribution of the TNF superfamily members CD 40 ligand and Fas ligand on T lymphocytes in cattle . ^^^ The bovine Fas ligand gene was partially cloned and mRNA expression determined by RT PCR in a panel of T cell clones . ^^^ Our results demonstrate that TH 0 and TH 1 bovine T cell clones expressed Fas ligand transcripts although only one gamma / delta T cell clone did . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Induction of apoptosis in the rheumatoid synovium by Fas ligand gene transfer . ^^^ To establish further the therapeutic effect of Fas mediated apoptosis on RA taking into consideration safety and practicality , we investigated the effect of cells transfected with human Fas ligand ( hFasL ) gene on proliferating human rheumatoid synovium engrafted in severe combined immunodeficiency ( SCID RA ) mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
During attempts to produce recombinant adenovirus expressing the apoptosis inducing molecule Fas ligand ( FasL ) under the control of a very strong truncated major immediate early human cytomegalovirus ( MIEhCMV ) promoter , we discovered that 293 cells were not surviving the initial cotransfection with a shuttle plasmid encoding the mouse FasL ; and pJM 17 , a plasmid containing the genome of adenovirus type 5 with deletions in the E 1 E3 regions , in an unpackagable form . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of Fas Ligand by macrophages and its upregulation by human immunodeficiency virus infection . ^^^ Fas / Fas Ligand ( FasL ) interactions play a significant role in peripheral T lymphocyte homeostasis and in certain pathological states characterized by T cell depletion . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Lymphocyte apoptosis induced by Fas ligand expressing ovarian carcinoma cells . ^^^ We now demonstrate that OvCAs in situ and in culture express functional Fas ligand ( FasL ) , capable of triggering an intrinsic cell death program in Fas expressing T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The cytokine possesses several biological properties such as activation of nuclear factor kappaB ( NF kappaB ) , Fas ligand expression , the induction of both CC and CXC chemokines , and increased production of competent human immunodeficiency virus . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
IL 2 increases transcription and surface expression of Fas ligand ( FasL ) and suppresses transcription and expression of FLIP , the inhibitor of apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand mediated lysis of self bystander targets by human papillomavirus specific CD8+ cytotoxic T lymphocytes . ^^^ P0 mice lysed RMA E 7 cells via Fas ligand ( FasL ) exclusively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand system may mediate antiproliferative activity of gonadotropin releasing hormone receptor in endometrial cancer cells . ^^^ We recently showed that GnRH stimulation induces intratumoral expression of the apoptosis inducing Fas ligand in human reproductive tract tumors . ^^^ To provide a potential association of Fas / Fas ligand system with the antiproliferative signaling process of GnRH receptor , we evaluated a correlation between the Fas ligand expression and the number of viable cells in two types of GnRH receptor bearing endometrial carcinomas that differ in Fas content . ^^^ Fas ligand protein was characterized by immunoblotting of membrane proteins with the specific antibody . ^^^ Time course analysis showed that Fas ligand production , which was already observed at day 2 ( p < 0 . 01 ) , precedes the onset of reduction in viable cell number . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cyclosporin A sensitive transcription factor Egr 3 regulates Fas ligand expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Flow cytometric profiles of doxorubicin treated HL 60 , K 562 , U 937 and Jurkat cells failed to show any significant increase in Fas or Fas ligand expression over 24 h , despite the induction of significant levels of apoptosis in these cells . ^^^ To determine whether recruitment of the Fas / Fas ligand complex during drug induced apoptosis was a cell specific event we utilized the CEM cell line . ^^^ Doxorubicin treatment of CEM cells over 24 h failed to show any up regulation in Fas or Fas ligand protein levels as detected by flow cytometry . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , the cytotoxicity of Fas ligand ( FasL ) cDNA transformants against human osteoblasts was increased when IGF 1 stimulated osteoblasts were used as target cells , indicating that stimulation of IGF 1 increased functional Fas expression on human osteoblasts as well as their proliferation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This study was undertaken to ( a ) determine if UDCA inhibits apoptosis from deoxycholic acid ( DCA ) , as well as from ethanol , TGF beta 1 , Fas ligand , and okadaic acid ; and to ( b ) determine whether mitochondrial membrane perturbation is modulated by UDCA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunological and pathological consequences of mutations in both Fas and Fas ligand . ^^^ To determine if Fas expressed in lpr mice is contributing to apoptosis we generated a novel strain of mice ( B6 / lprgld ) which is homozygous for both the lpr mutation and the gld mutation which encodes nonfunctional Fas ligand ( FasL ) protein . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Neither of these NK subsets were shown to express Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Further , at least one autoimmune disease results from a defined defect of apoptosis ( mutations of the Fas ligand or its receptor ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Fas ligand interactions are involved in ultraviolet B induced human lymphocyte apoptosis . ^^^ We wondered whether the apoptosis known to occur after UV B irradiation might involve the Fas / Fas ligand ( FasL ) signaling pathway . ^^^ After UV B irradiation , PBLs showed increased expression of Fas ligand ; the E 6 1 lymphocytic cell line also released soluble FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
After cerebral ischemia reperfusion , phosphorylation of c Jun was linked with induced expression of Fas ligand ( APO 1 , CD 95 ligand ) , whose gene is a putative c Jun / AP 1 target , and with terminal deoxynucleotidyl transferase mediated biotinylated UTP nick end labeling ( TUNEL ) reactivity , a marker for apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Raised plasma soluble Fas and Fas ligand in alcoholic liver disease . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This method was successfully applied to detect and localize mRNA transcripts for Fas ligand within the immune privileged placental environment and to provide verification of immunohistochemical localization of gene product . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis induced by DNA damage and other stresses can proceed via expression of Fas ligand ( FasL ) and ligation of its receptor , Fas ( CD 95 ) . ^^^ DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF kappa B and AP 1 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here we report that IFN gamma up regulated the expression of Fas and Fas ligand ( FasL ) on HT 29 cells , a human colon adenocarcinoma cell line , and subsequently induced apoptosis of these cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Upregulation of Fas ligand secretion in non lymphopenic stages of HIV 1 infection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Moreover , when CD4+ T cells of HAM patients were preincubated with a monoclonal antibody to human Fas ligand ( FasL ) , cytotoxic activity against T98G was significantly suppressed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Fas ligand and hematopoietic progenitor cells . ^^^ These findings suggest that the Fas / Fas ligand system is closely related to the maintenance of homeostasis during the process of normal hematopoiesis . ^^^ Increased Fas ligand expression is observed on natural killer lymphoma cells and may be associated with the pathogenesis of failure of several organs . ^^^ The Fas / Fas ligand system plays an important role in the physiologic and pathologic processes of hematopoiesis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this study , we screened for the expression of bcl 2 homologues ( bcl 2 , bax , bcl xl , and bcl xs ) and Fas ligand ( FasL ) by RT PCR method in grafts during acute rejection in rats following liver transplantation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunohistochemical study of Fas , Fas ligand and interleukin 1 beta converting enzyme expression in human prostatic cancer . ^^^ OBJECTIVE : To determine the cellular expression of Fas , Fas ligand and interleukin 1 beta converting enzyme ( ICE ) in prostatic cancer . ^^^ Paraffin embedded sections were cut from the specimens and stained immunohistochemically to detect Fas , Fas ligand and ICE . ^^^ RESULTS : Fas was expressed in all 21 of the cancer specimens while Fas ligand was detected in none and ICE was expressed in 11 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
While ceramide has been shown to be an important regulatory component of apoptosis induced by tumor necrosis factor alpha and Fas ligand , sphingosine 1 phosphate ( SPP ) , a further metabolite of ceramide , has been implicated as a second messenger in cellular proliferation and survival induced by platelet derived growth factor , nerve growth factor , and serum . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand mediated depletion of CD 4 and CD 8 lymphocytes by monomeric HIV 1 gp 120 . ^^^ Bioassay of the Fas ligand ( FasL ) demonstrated augmented expression and release of soluble FasL by CD 4 T cells in the supernatant of this culture . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Levels of soluble Fas ligand in myocarditis . ^^^ Serum levels of soluble Fas ligand ( sFasL ) increased with the severity of congestive heart failure ( p < 0 . 01 ) , and the percentages of apoptotic myocytes detected by in situ DNA nick end labeling were significantly higher in the patients with increased levels of sFasL than in those with normal levels of sFasL ( p < 0 . 05 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas antigen ( Fas ) Fas ligand pathway is involved in cytotoxic T lymphocyte and natural killer cell mediated cytotoxicity . ^^^ Like the Fas ligand , anti Fas monoclonal antibody ( mAb ) induces apoptosis in tumor cells expressing Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
PURPOSE : The interaction of Fas antigen ( Fas ) and Fas ligand plays an important role in cytotoxic T lymphocyte and natural killer cell mediated cytotoxicity against cancer cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis related protein immunoreactivity defined presence and location of Bax , Fas , Fas Ligand ( FasL ) , Bcl 2 , interleukin 1 beta converting enzyme ( ICE ) , inducible nitric oxide synthase ( iNOS ) and the proto oncogene p 53 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RESULTS : Keratocyte apoptosis , mediated through the release of cytokines such as soluble Fas ligand and interleukin 1 from the injured epithelium , occurs following refractive surgical procedures like photorefractive keratectomy ( PRK ) and laser in situ keratomileusis ( LASIK ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Human melanoma reactive CD4+ and CD8+ CTL clones resist Fas ligand induced apoptosis and use Fas / Fas ligand independent mechanisms for tumor killing . ^^^ Tumor cells have been shown recently to escape immune recognition by developing resistance to Fas mediated apoptosis and acquiring expression of Fas ligand ( FasL ) molecule that they may use for eliminating activated Fas+ lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Thus , IL 12 and IL 18 produced by LPS stimulated Mac 1+ cells stimulate this unique subpopulation of T cells to produce IFN gamma , which in combination with Fas ligand , inhibits IgE production from the B cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Involvement of the Fas / Fas ligand pathway in activation induced cell death of mycobacteria reactive human gamma delta T cells : a mechanism for the loss of gamma delta T cells in patients with pulmonary tuberculosis . ^^^ Mtb Ag stimulation rapidly induced Fas and Fas ligand ( FasL ) expression by gamma delta T cells , and in the presence of metalloproteinase inhibitors > 70 % of gamma delta T cells were FasL+ . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A second target is the T cell , and strategies rely on a gene transfer approach to switch on T cell apoptosis using Fas ligand , or to modulate T cell populations with cytokines . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Both murine kidney cortex and RTC in culture demonstrated constitutive expression of transmembrane and soluble forms of RTC Fas ligand , features that are primarily restricted to lymphocytes and immune privileged tissues and that have been previously unrecognized in RTC . ^^^ Functional studies revealed that interleukin 1alpha stimulated RTC Fas expression was accompanied by increased apoptosis , which was inhibited by blocking anti Fas ligand antibodies . ^^^ In contrast to the conventional paradigm , which holds that Fas dependent apoptosis is initiated by the binding of lymphocyte Fas ligand to target cell Fas , our data suggest that up regulated RTC Fas binds to Fas ligand on adjacent RTC , which then leads to RTC death by fratricide . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The soluble form of Fas ( sFas ) can block apoptosis induced by the Fas ligand in vitro . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Efficient ex vivo inhibition of perforin and Fas ligand expression by chimeric tRNA hammerhead ribozymes . ^^^ Research in rodent models has linked perforin and Fas ligand ( FasL ) , two components of independent lytic pathways , with the induction of GVHD . ^^^ In this study we characterized two hammerhead ribozymes that cleave their target perforin and Fas ligand RNAs with high efficiency in CTLL 2 cells . ^^^ The perforin and Fas ligand ribozymes were expressed from a tRNA directed RNA polymerase 3 promoter that was inserted in an episomal multicopy plasmid derived from papilloma virus . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Transformation dependent susceptibility of rat hepatic stellate cells to apoptosis induced by soluble Fas ligand . ^^^ We characterized the susceptibility of HSC in primary culture and of MFB in secondary culture to apoptosis induced by the soluble Fas ligand ( sFasL ) and related the effects to the expression levels of Fas ( APO 1 / CD95 ) and some major proapoptotic and contra apoptotic protooncogenes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A new view on immune adrenal interactions : role for Fas and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : Fas ligand ( FasL ) expression was detected by flow cytometry and immunohistochemistry . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Serum deprivation induced apoptosis in cultured porcine granulosa cells is characterized by increased expression of p 53 protein , Fas antigen and Fas ligand and by decreased expression of PCNA . ^^^ Data indicated that serum deprivation induced GC apoptosis characterized by DNA laddering , which was associated with decreased expression of proliferating cell nuclear antigen ( PCNA ) and increased expression of p 53 protein , Fas antigen and Fas ligand . ^^^ This suggests that serum removal from primary GCs may activate multiple apoptotic pathways such as a p 53 associated pathway and a Fas Fas ligand pathway . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( CD 95 ) , Fas ligand ( FasL ) and Bcl 2 . ^^^ Fas ( CD 95 ) , Fas ligand ( FasL ) and Bcl 2 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Improved survival of biolistically transfected mouse islet allografts expressing CTLA 4 Ig or soluble Fas ligand . ^^^ We investigated whether local expression of human CTLA 4 Ig or soluble human Fas ligand from biolistically transfected mouse islets would have a protective effect on allograft survival . ^^^ The experimental groups were naked gold particles ( n=6 ) , empty vector DNA ( n=5 ) , DNA encoding human CTLA 4 Ig ( n=8 ) , or soluble human Fas ligand ( n=5 ) . ^^^ In the soluble human Fas ligand group , 80 % of grafts survived > or = 50 days . ^^^ CONCLUSION : Our results indicate that local production of human CTLA 4 Ig or soluble human Fas ligand by biolistically transfected islets can promote allograft survival . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This system allows for study of the relative contributions of perforin / granzyme B ( GrB ) and Fas ligand ( FasL ) based cytotoxicity to killing of PTEC . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The factors responsible for this include presence of the blood aqueous barrier , the avascularity of the cornea , the absence of classic antigen presenting cells ( APCs ) in the central cornea , inhibitory factors in the aqueous humor , the phenomenon known as anterior chamber associated immune deviation ( ACAID ) , and the intraocular expression of Fas ligand . ^^^ Loss of ocular immune privilege can occur with breaching of the blood ocular barrier , corneal neovascularization , migration of classic APCs to the center of the cornea , loss of inhibitory factors in aqueous humor , abrogation of ACAID , and loss of Fas ligand expression within the anterior chamber . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We also examined whether lymphocytes could undergo Fas mediated apoptosis with anti CD 95 monoclonal antibody ( MAb ) or human Fas ligand expressing fibroblasts , and if synovial fluid contained a soluble factor ( s ) that could inhibit such interactions . ^^^ Deficient Fas ligand expression by synovial lymphocytes from patients with rheumatoid arthritis . ^^^ Finally , we determined whether anti CD 3 MAb could induce synovial T cells to express the Fas ligand in vitro . ^^^ Instead , we detected little or no expression of Fas ligand by RA synovial lymphocytes . ^^^ However , we could induce such cells to express Fas ligand with anti CD 3 MAb or phorbol ester and ionomycin in vitro . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Dysregulated expression of B7 . 2 on tolerant B cells caused a more extreme reversal of peripheral tolerance than that caused by defects in Fas or Fas ligand , and resulted in T cell dependent clonal expansion and antibody secretion comparable in magnitude to that made by foreign antigen specific B cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Western analysis showed that with IL 8 , there was a marginal decrease of total Fas protein , whereas Fas ligand was increased . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Stress induced Fas ligand expression in T cells is mediated through a MEK kinase 1 regulated response element in the Fas ligand promoter . ^^^ While the mechanism by which stress stimuli induce apoptosis is not well understood , we have previously shown that the induction of Fas ligand ( FasL ) gene expression by environmental stress stimuli is dependent on c Jun N terminal kinase ( JNK ) activation . ^^^ Using inducible dominant active ( DA ) JNK kinase kinase ( MEKK 1 ) expression in Jurkat cells , we map a specific MEKK 1 regulated response element to positions 338 to 316 of the Fas ligand ( FasL ) promoter . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Involvement of NF AT in type 1 human T cell leukemia virus Tax mediated Fas ligand promoter transactivation . ^^^ Human T cell leukemia virus type 1 ( HTLV 1 ) infected T cells constitutively express surface Fas ligand ( FasL ) , which may serve as a mechanism of viral pathogenesis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / APO 1 ( CD 95 ) is a cell surface protein inducing an apoptotic signal after its binding to Fas ligand or to a functional anti Fas antibody . ^^^ Fas / APO 1 ( CD 95 ) is a cell surface protein inducing an apoptotic signal after its binding to Fas ligand or to a functional anti Fas antibody . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis and the expression of Fas and Fas ligand antigen after orthotopic liver transplantation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand in discordant xenogeneic antibody dependent cell mediated cytotoxicity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TNF related apoptosis inducing ligand ( TRAIL ) induces apoptosis in Fas ligand resistant melanoma cells and mediates CD 4 T cell killing of target cells . ^^^ We have previously shown that melanoma cells were resistant to apoptosis induced by TNF family members Fas ligand ( FasL ) , TNF alpha , and CD40L . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ligation of Fas by specific Abs or Fas ligand ( FasL / CD95 ligand ) induces rapid apoptotic cell death in a variety of cell types . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In a separate series of experiments graft mRNA was extracted and analysed by reverse transcription polymerase chain reaction ( RT PCR ) with primers for molecular inducers of apoptosis ( TNF alpha , Fas ligand , perforin , and granzyme B ) which are derived from cytolytic cells known to be present in allografts . ^^^ RT PCR on whole allografts in both strain combinations revealed sustained upregulation of perforin , granzyme B , Fas ligand and TNF alpha mRNA concomitant with medial SMC loss . ^^^ Autografts demonstrated sustained up regulation of TNF alpha , and perforin , but only brief upregulation of granzyme B , and no upregulation of Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition to CD 4 , islet mRNA from these mice also showed expression of CD 8 , IFNgamma , TNFalpha , Fas , and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The ability to prevent rejection was minimally affected by the presence of a defect in Fas ligand binding or by the absence of granzyme B but was severely affected by the absence of perforin . ^^^ Doubly mutant perforin deficient , Fas ligand defective CD 8 cells were completely unable to prevent rejection . ^^^ Our results indicate first that recipient CD 8 effectors responsible for causing marrow graft rejection are sensitive to cytotoxicity mediated by both perforin and Fas ligand dependent mechanisms , and second that donor T cells must have at least one functional cytotoxic mechanism to prevent allogeneic marrow graft rejection . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interestingly , both stimuli induced the expression of the Fas receptor , but with different kinetics , while the Fas ligand ( FasL ) was expressed constitutively in SPGM 1 cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To investigate regulation of apoptosis in rats with PAN , we evaluated the expression of p 53 , Fas antigen , Fas ligand and Bc 1 2 . ^^^ However , they were negative for p 53 , Fas antigen , and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Utility of adenoviral mediated Fas ligand gene transfer to modulate islet allograft survival . ^^^ BACKGROUND : One of the best defined mechanisms for the induction of apoptosis involves signaling via the cell surface molecule Fas , after binding of Fas ligand . ^^^ Expression of Fas ligand is tightly regulated , being expressed primarily by T cells after activation , where it serves as a self regulatory mechanism for immune responses . ^^^ Fas ligand has also been found to be expressed constitutively at sites of immune privilege such as the testes and the anterior chamber of the eye . ^^^ Recently , co transplantation of Fas ligand transfected myoblasts in association with islet cell allografts was shown to prolong islet allograft survival but only rarely led to indefinite graft survival . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To determine which effector mechanisms of CD 8 ( + ) T cells , granule exocytosis or Fas ligand expression , play a role in the development of demyelination and clinical disease , we infected perforin deficient , lpr ( Fas mutation ) , and gld ( Fas ligand mutation ) mice with TMEV . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Plasma soluble fas and soluble fas ligand in chronic glomerulonephritis . ^^^ Fas induces apoptosis when it binds to Fas ligand ( Fas L ) or soluble Fas L ( sFas L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Neutrophils from human peripheral blood express Fas ( CD 95 ) and are sensitive to Fas ligand ( FasL ) / Fas mediated apoptosis . ^^^ Fas ligand ( gld ) and Fas ( lpr ) deficient mice do not show alterations in the extravasation or apoptosis of inflammatory neutrophils . ^^^ Mice carrying spontaneous mutations in the genes for fas ligand ( B6 / gld ) or fas ( B6 / lpr ) were used to assess the role of FasL / Fas in the kinetics and magnitude of neutrophil extravasation to the thioglycolate ( TG ) inflamed peritoneum and in the spontaneous apoptosis of TG elicited neutrophils . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : Fas ( APO 1 / CD95 ) is a member of the tumor necrosis factor receptor ( TNF R ) family and induces apoptosis when crosslinked with either Fas ligand or agonistic antibody ( Fas antibody ) . ^^^ The Fas Fas ligand system has an important role in the immune system where it is involved in the downregulation of immune responses and the deletion of peripheral autoreactive T lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas ( sFas ) is produced as an alternatively spliced product of the Fas gene and protects cells from apoptosis due to antagonization of the binding between membrane form of the Fas gene ( mFas ) and the Fas ligand . ^^^ To determine the role of the Fas / Fas ligand system in silica induced immunological abnormalities , we investigated Fas and Fas ligand message expression levels using the multiplex reverse transcription polymerase chain reaction ( RT PCR ) method with peripheral blood mononuclear cells from silicosis cases with no clinical symptoms of autoimmune diseases . ^^^ Although the relative expression levels of the Fas or Fas ligand genes were not remarkably altered in these cases , we observed the sFas message was dominantly expressed compared with mFas expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Rapid prelytic phosphatidylserine externalization was induced in Jurkat target cells by both the Fas ligand ( FasL ) / Fas and the granule exocytosis effector pathways . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Differential expression of Fas and Fas ligand in acute and chronic graft versus host disease : up regulation of Fas and Fas ligand requires CD8+ T cell activation and IFN gamma production . ^^^ The parent into F 1 model of acute and chronic graft vs host disease ( GVHD ) was used as an example of in vivo cell mediated or Ab mediated responses , respectively , and the roles of Fas and Fas ligand ( FasL ) were investigated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Evidence for the involvement of Fas ligand and perforin in the induction of vascular leak syndrome . ^^^ Also , Fas ligand defective ( gld ) mice and Fas deficient ( lpr ) mice exhibited decreased VLS in the liver and spleen , but not in the lungs . ^^^ The current study demonstrates for the first time that perforin and Fas ligand may actively participate in endothelial cell injury and induction of VLS in a variety of organs . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We demonstrated that a single intraperitoneal injection of NMDA produces persistent expression of c fos , c jun , Fas , and Fas ligand ( FasL ) mRNA in the hippocampus for 5 months . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas , fas ligand , immune tolerance , and cancer : implications in cancer of the colon ] . ^^^ Fas and Fas ligand ( FasL ) are implicated in programmed cell death or apoptosis . ^^^ Fas ligand expression on thymocytes , activated T lymphocytes , and in sites of immune privilege , suggests the importance of Fas / FasL interactions in negative control of the immune response . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : We have shown previously that heightened expression of the cytotoxic lymphocyte ( CL ) effector genes perforin ( P ) , granzyme B ( GB ) , and Fas ligand ( FasL ) , is closely correlated with acute allograft rejection , particularly when two or more target genes are up regulated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Consequences of Fas ligand and perforin expression by colon T cells in a mouse model of inflammatory bowel disease . ^^^ The aims of this study were to determine the relative contribution of perforin and Fas ligand ( Fas L ) expression to the cytotoxic action of these T cells and to examine the influence of each pathway in this model of colitis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas / Fas ligand system : implications in the antitumor immune response and in the activity of cytotoxic agents ] . ^^^ Interaction of Fas ligand ( Fas L ) with the extracytoplasmic domain of the Fas receptor can induce Fas trimerization and activation of the apoptotic cell death process . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Also , tumor cells can acquire attributes that interfere with an immune response , including down regulation of MHC molecules or other molecules involved in antigen processing ; secretion of the immunosuppressive cytokine TGFbeta ; and expression of the apoptosis inducing surface molecule , Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The soluble form of CH 11 and other immobilized anti Fas mAb ( UB 2 , ZB 4 ; IgG type ) failed to stimulate lupus T cells while immobilized human Fas ligand did . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Clinical significance of serum soluble Fas ligand in patients with acute self limited and fulminant hepatitis . ^^^ The Fas ligand ( FasL ) , a member of the tumor necrosis factor family , induces apoptosis in Fas expressing cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Human colon cancer cells express the functional Fas ligand . ^^^ Fas ligand ( FasL ) belongs to the TNF superfamily . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In view of the expression of fas by the activated T cells and of fas ligand by the melanoma cells , blockade of potential fas / fas ligand interactions was undertaken using monoclonal antibodies ( mAb ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Molecular cloning , expression and characterization of rhesus macaque Fas ligand cDNA . ^^^ The Fas / Fas ligand ( FasL ) interaction is pivotal in apoptosis mediated regulation of the immune system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Identification of two NF kappa B sites in mouse CD 95 ligand ( Fas ligand ) promoter : functional analysis in T cell hybridoma . ^^^ Fas ligand ( FasL ) gene expression is critically involved in peripheral T cell tolerance and lymphocyte homeostasis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It was recently reported that human and mouse melanoma cells express Fas ligand ( FasL ) but almost no Fas , which may contribute to their immune privilege . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis by retrovirus and adenovirus mediated gene transfer of Fas ligand to glioma cells : implications for gene therapy . ^^^ When U 251 transfectants with high level Fas expression were transduced with Fas ligand encoding gene via retrovirus , they were unaffected by exposure to anti Fas antibody or Fas ligand adenovirus ( Adeno FL ) . ^^^ Thus , retroviral induction of Fas ligand into the glioma cells with high levels of Fas led to the selection of cells that were resistant to Fas dependent apoptosis . ^^^ These resistant U 251 transfectants were susceptible to FADD adenovirus ( Adeno FADD ) induced apoptosis , indicating that a cascade of death signals was blocked at the steps between Fas ligand and FADD . ^^^ As for adenoviral transduction of Fas ligand into gliomas , gliomas with a relatively high level of expression of Fas were remarkably sensitive to Adeno FL induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Under these conditions , the T cells co express Fas ( CD 95 ) and Fas ligand ( FasL ) , and engagement of Fas triggers apoptotic death of the T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas fas ligand system induced apoptosis in human placenta and gestational trophoblastic disease . ^^^ We studied Fas ligand ( FasL ) expression and apoptosis in normal and pathologic placentas to find out whether the Fas FasL induced apoptosis takes place during implantation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand ( FasL ) by the human trophoblast has been proposed as a mechanism providing protection against the lytic action of decidual immune cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
One of the mechanisms is mediated through the Fas and Fas ligand ( FasL ) pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand is expressed in normal skin and in some cutaneous malignancies . ^^^ Fas , a cell surface receptor and member of the tumour necrosis factor receptor superfamily , induces apoptosis upon oligomerization by its ligand ( Fas ligand : FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL , CD95L , APO 1L ) expression in murine mast cells . ^^^ Fas ligand ( FasL , CD95L , Apo 1L ) , a type 2 membrane protein belonging to the tumour necrosis factor family , induces apoptosis in Fas bearing cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunohistological examination has revealed the infiltration of activated CD4+ T cells , which express Fas ligand ( FasL ) , in RA synovium . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
High Fas ligand expression on lymphocytes in lesions of ulcerative colitis . ^^^ The Fas ligand ( FasL ) , expressed on cytotoxic T lymphocytes , induces apoptosis in cells expressing Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Signals to apoptosis from outside of the cell including Fas and Fas ligand interaction and sphingomyelin cycle were presented . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Keratinocytes normally express the death receptor Fas ( CD 95 ) ; those from TEN patients were found to express lytically active Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Glandular and extraglandular expression of the Fas Fas ligand and apoptosis in patients with Sjgren ' s syndrome . ^^^ OBJECTIVE : To evaluate the role of Fas Fas ligand system mediated apoptosis in the sialoadenitis and interstitial nephritis of Sjgren ' s syndrome . ^^^ METHODS : The expression of Fas antigen and Fas ligand in sialoadenitis and interstitial nephritis was examined by immunoperoxidase staining and the reverse transcriptase polymerase reaction ( RT PCR ) in patients with Sjgren ' s syndrome and in normal subjects . ^^^ In patients with massive mononuclear cell infiltration , some of the infiltrating cells showed the Fas ligand . ^^^ In the patients with interstitial nephritis , some of the infiltrating cells showed the Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Human Jurkat T cells undergoing Fas ligand mediated apoptosis in response to CD 3 activation were completely resistant when transfected with FLIP . ^^^ Moreover , the Fas ligand , but not the perforin / granzyme B dependent lytic pathway of CTL , was inhibited by FLIP . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , cells pretreated with IFN gamma and TNF alpha are sensitive to lysis mediated by Fas ligand ( FasL ) expressing hybridomas ( dllS ) , cross linking of anti Fas Abs or soluble Fas ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand are critical regulators of lymphocyte homeostasis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This increase in paclitaxel or etoposide induced apoptosis of HL 60 / Apaf 1 cells was not associated with any significant alterations in Bcl 2 , Bcl xL , Bax , Fas , or Fas ligand expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
As a demonstration of their functional utility , we used CAR expressing lymphocytes transduced with an adenovirus expressing Fas ligand to efficiently kill Fas receptor expressing tumor cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We determined the expression of Fas ( CD 95 ) , Fas Ligand ( Fas L ) and TNF alpha factors known to be involved in apoptosis , in the marrow of 44 patients with MDS and characterized their functional relevance in in vitro assays of haemopoiesis . ^^^ A role for tumour necrosis factor alpha , Fas and Fas Ligand in marrow failure associated with myelodysplastic syndrome . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Exogenous Fas ligand had no effect on MCL cells , whereas exogenous CD 40 ligand enhanced their survival and rescued them from fludarabine induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Moreover , although we failed to detect Fas ligand expression on PMN surface , treatment of cell cultures with antagonistic anti Fas IgG 1 ( ZB 4 ) mAbs determined a significant inhibition of spontaneous apoptosis in neutrophils from both groups of subjects , thus suggesting that the Fas / Fas ligand system is in fact involved in such an event . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activation of T lymphocytes often leads to cellular activation , production of cytokines , entry into cell cycle , and expression of Fas ( CD 95 ) and Fas ligand ( FasL ) . ^^^ Fungal metabolite FR 901228 inhibits c Myc and Fas ligand expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Chemotactic activity of soluble Fas ligand against phagocytes . ^^^ A recombinant soluble form of human Fas ligand ( sFasL ) was tested for its chemotactic activity against human and mouse polymorphonuclear neutrophils ( PMN ) by the Boyden chamber method . sFasL exhibited a potent chemotactic activity against both human and mouse PMN and HL 60 cells when differentiated into neutrophils or monocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tumor expression of Fas ligand ( CD95L ) and the consequences . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL ) is naturally expressed on the vascular endothelium where it can induce apoptosis in Fas expressing immune cells as they enter the vessel wall . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand interactions suppress melanoma lung metastasis . ^^^ To determine whether Fas loss of function is critical for acquisition of the metastatic phenotype , we have compared the ability of Fas sensitive K 1735 murine melanomas to form spontaneous lung metastases in wild type and Fas ligand deficient mice . ^^^ However , in Fas ligand deficient mice , both the incidence and number of metastases are increased . ^^^ These findings provide the first evidence that Fas Fas ligand interactions can suppress metastasis and that tumor Fas loss of function may be causally linked to metastatic progression . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Membrane and soluble forms of Fas ( CD 95 ) and Fas ligand in peripheral blood mononuclear cells and in plasma from human immunodeficiency virus infected persons . ^^^ The expression of membrane bound Fas ligand ( FasL ) and Fas in lymphocytes and monocytes and levels of soluble forms of FasL ( sFasL ) and Fas ( sFas ) in plasma from human immunodeficiency virus ( HIV ) positive and negative subjects was evaluated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis , proliferation , and expression of Bcl 2 , Fas , and Fas ligand in bronchial biopsies from asthmatics . ^^^ The in situ apoptosis and the expression of molecules involved in this process , such as Bcl 2 , Fas , and its ligand , Fas ligand ( FasL ) , were examined in bronchial biopsies from healthy control subjects and from steroid untreated or treated asthmatics , using terminal transferase mediated deoxyuridyltriphosphate nick end labeling and immunohistochemical techniques , respectively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , it has been shown that cotransplantation of Fas ligand ( FasL ) expressing cells can induce functional allograft tolerance in some model systems . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Caspase 1 independent IL 1beta release and inflammation induced by the apoptosis inducer Fas ligand . ^^^ Fas ligand is a well characterized apoptosis inducer . ^^^ Here we demonstrate that Fas ligand induces the processing and secretion of interleukin 1beta ( IL 1beta ) in peritoneal exudate cells . ^^^ Inoculation of tumor cells expressing Fas ligand into wild type mice induces a massive neutrophil infiltration that is , in contrast , suppressed in IL 1alpha / beta knockout mice . ^^^ These results demonstrate a newly discovered role for Fas ligand in inflammation , and challenge the dogma that apoptosis does not induce inflammation . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Both death signals ( TNT alpha , Fas ligand ) and survival signals ( LIF , kit ligand ) are present in the embryonic gonad . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We demonstrate that in vitro , NF kappaB controlled expression of numerous inflammatory molecules in synoviocytes and protected cells against tumor necrosis factor alpha ( TNFalpha ) and Fas ligand ( FasL ) cytotoxicity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recently , the Fas ( CD95 / APO 1 ) / Fas ligand system has been identified as a key regulator of apoptosis in some types of lymphoma cell lines . ^^^ Therefore , the high radiosensitivity of malignant lymphoma among our samples could be explained by the overexpression of Fas antigen induced by small doses of radiation therapy , and Fas ligand could be produced by infiltrating lymphocytes or may be expressed simultaneously on the lymphoma cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cytotoxic immune lymphocytes kill target cells via the perforin / granzyme and the Fas ligand ( Fas L ) pathways . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Predominant expression of Fas ligand mRNA in CD8+ T lymphocytes in patients with HTLV 1 associated myelopathy . ^^^ To determine if Fas ligand ( FasL ) mediated apoptosis is involved in the pathogenesis of HTLV 1 associated myelopathy / tropical spastic paraparesis ( HAM / TSP ) , we examined the expression of FasL mRNA in fresh uncultured peripheral blood mononuclear cells ( PBMC ) from 17 Japanese patients with HAM / TSP , four adult T cell leukemia / lymphoma ( ATL ) patients , three asymptomatic HTLV 1 carriers and three normal individuals . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Is Fas ligand or endotoxin responsible for mucosal lymphocyte apoptosis in sepsis . ^^^ DESIGN : Male C3H / HeN ( endotoxin sensitive ) , C3H / HeJ ( endotoxin tolerant ) , and C3H / HeJ FasLgld ( endotoxin tolerant / Fas ligand [ FasL ] deficient ) mice were subjected to sepsis ( cecal ligation and puncture [ CLP ] ) and IELs were harvested at 4 ( early ) or 24 hours ( late sepsis ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , while influenza peptide / MHC elicited both perforin and Fas ligand ( FasL ) / Fas ( CD95L / CD95 ) mediated cytolytic mechanisms , SEB was unable to trigger perforin mediated cytolysis or serine esterase release . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Hence , the regulation of cPLA 2 is a key event in the induction of inflammatory responses . cPLA 2 is activated , in part , by apoptotic stimuli such as TNF or Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Stimulation of the 5 delta 1 clones was optimal in the presence of Borrelia , dendritic cells , and exogenous IL 2 , which was reflected by proliferation , TCR down modulation , as well as induction of CD 25 and Fas ligand expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
An anti CD 19 antibody coupled to a tetanus toxin peptide induces efficient Fas ligand ( FasL ) mediated cytotoxicity of a transformed human B cell line by specific CD4+ T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression and function of Fas and Fas ligand on peripheral blood lymphocytes in normal subjects . ^^^ We investigated the expression and function of Fas and Fas ligand ( FasL ) on peripheral blood lymphocytes ( PBLs ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND / AIMS : In chronic hepatitis C , the expression of Fas antigen on hepatocytes is upregulated and Fas ligand expression is detected on liver infiltrating mononuclear cells . ^^^ Thus Fas antigen / Fas ligand mediated apoptosis is thought to be involved in hepatic injury in chronic hepatitis C . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Regulated and endothelial cell specific expression of Fas ligand : an in vitro model for a strategy aiming at inhibiting xenograft rejection . ^^^ BACKGROUND : Immunologically privileged sites have been shown to express Fas ligand ( FasL ) and may protect themselves by inducing apoptosis of infiltrating inflammatory cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recent studies indicate that Fas and Fas ligand are involved in apoptosis of T cells in HIV infected patients . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Further , 9 cryosections from MF lesions and 9 from SS lesions were stained for LFA , ICAM 1 , CD 40 , CD 40 ligand , CD 28 , CD 80 , CTLA 4 , CD 86 , FAS , FAS ligand , CLA and CD15s . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Among the several pathways which function to induce apoptosis , Fas and the Fas ligand system have been thought to play an important role in inducing tumour cell apoptosis , particularly in immunological prevention . ^^^ In addition , the apoptosis induced by IFN alpha did not seem to be mediated by the Fas / Fas ligand pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Induction of Fas ligand and Fas antigen mRNA expressions in interferon gamma transgenic mouse liver . ^^^ The polymerase chain reaction revealed induction of Fas antigen and Fas ligand mRNA expressions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Antitumor activity exhibited by Fas ligand ( CD95L ) overexpressed on lymphoid cells against Fas+ tumor cells . ^^^ Lymph node ( LN ) cells of Fas mutant mice lpr / lpr ( lpr ) and lpr ( cg ) / lpr ( cg ) ( lpr ( cg ) ) express an increased level of Fas ligand ( FasL ) ( CD95L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Induction of specific T cell tolerance by adenovirus transfected , Fas ligand producing antigen presenting cells . ^^^ In this study , the immune response to adenovirus was prevented by induction of specific T cell tolerance by pretreatment with adenovirus infected antigen presenting cells ( APC ) that express Fas ligand . ^^^ Our results indicate that adenovirus specific T cell tolerance can be induced by APCs that coexpress Fas ligand and adenovirus antigens . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand a double edged sword . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Regulation of the proinflammatory effects of Fas ligand ( CD95L ) . ^^^ Fas ligand ( CD95L ) inhibits T cell function in immune privileged organs such as the eye and testis , yet in most tissues CD95L expression induces potent inflammatory responses . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Death factors such as Fas ligand induce apoptosis by triggering a series of intracellular protein protein interactions mediated by defined motifs found in the signaling molecules . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas antigen is a transmembrane receptor belonging to the tumor necrosis factor alpha ( TNF ) receptor family that , when activated by Fas ligand or agonistic antibodies , induces death by apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The binding of Fas ligand to Fas recruits caspase 8 to Fas via an adaptor , FADD / MORT1 , and activates a caspase cascade leading to apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the current study , we investigated whether the naive , poly 1 : C or interleukin 2 ( IL 2 ) induced natural killer ( NK ) / lymphokine activated killer ( LAK ) cells use perforin and / or Fas ligand ( FasL ) to mediated cytotoxicity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Moreover , both TNF alpha and Fas ligand expressions in the liver were decreased by anti TARC treatment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We have previously shown that pulmonary T lymphocytes from untreated asthmatic subjects do not express surface Fas receptors nor do they contain Fas mRNA , yet they display normal levels of Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This contrasts with the anti apoptotic influence of Bcl 2 family proteins in the cell death pathway induced by Fas ligand or tumor necrosis factor ( TNF ) , in which Bcl 2 typically acts downstream of Fas / TNFR1 mediated activation of caspase 8 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Specifically , hyaluronidase upregulated p 53 protein expression ( > 200 % ) but down regulated a p 85 inter alpha inhibitor like protein ( > 90 % ) in L 929 cells , whereas it had no effect on the protein levels of ICH 1 , Bcl xL , Bcl 2 , Fas ligand , CAS ( cellular apoptosis susceptible protein ) , TIAR ( an RNA binding protein ) and alpha tubulin . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Molecular cloning of feline Fas antigen and Fas ligand cDNAs . ^^^ The Fas antigen ( FasA ) and Fas ligand ( FasL ) are key molecules which mediate apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the pleural effusion of the present case , abnormally high levels of soluble Fas ligand , interleukin 10 and interferon gamma were detected . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Jurkat cells express Fas , and rapidly undergo apoptosis in response to Fas ligand or an agonistic anti Fas antibody . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Second , because Fas ligand ( FasL ) may contribute to immune privilege , we tested whether functional FasL expression by the fetus , or Fas expression by the mother , contributes to successful reproduction in a fully allogeneic breeding . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis promoting molecules , Fas antigen and Fas ligand were observed in ductal and acinar epithelial cells as well as in infiltrating mononuclear cells of minor salivary glands from SS patients in comparison with control biopsies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To examine the role of the glandular epithelial cells in the pathogenesis of autoimmune exocrinopathy , we studied Fas and Fas ligand ( FasL ) expression and quantitated the levels of apoptosis in salivary and lacrimal glands from NOD and NOD scid mice , an animal model that develops a Sjgren ' s syndrome like pathology . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Defects in CD95 / CD95L ( Fas Ligand ) apoptotic pathway have been recognized in autoimmune lymphoproliferative diseases ( ALPS ) and lpr or gld mice and attributed to CD 95 and CD95L gene mutations , respectively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( CD 95 ) and Fas ligand ( FasL ) play major roles in staphylococcal enterotoxin B ( SEB ) induced peripheral deletion of Vbeta8+ T cells . ^^^ Inducible nonlymphoid expression of Fas ligand is responsible for superantigen induced peripheral deletion of T cells . ^^^ Fas ( CD 95 ) and Fas ligand ( FasL ) play major roles in staphylococcal enterotoxin B ( SEB ) induced peripheral deletion of Vbeta8+ T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Newly discovered role for Fas ligand in the cell cycle arrest of CD4+ T cells . ^^^ Fas Ligand ( FasL ) can induce apoptosis of Fas bearing cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This may be due to chronic T cell activation , which can lead to the induction of apoptosis via the Fas / Fas ligand pathway . ^^^ Fas ligand expression was also observed , not only on most of the T cells but also on all macrophages . ^^^ Because macrophages were often detected in close contact with T cells , they may play a role in T cell regulation via the Fas / Fas ligand pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand is present in tumors of the Ewing ' s sarcoma family and is cleaved into a soluble form by a metalloproteinase . ^^^ Fas ligand ( FasL ) exists in transmembrane and soluble forms and induces apoptosis on cross linking with the Fas receptor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This conclusion is discussed in terms of known polymorphic differences between these mouse strains at genetic loci governing ( a ) immune responsiveness , ( b ) alloform of Fas ligand , and ( c ) bias of immune response toward Th 1 or Th 2 phenotypes . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas upregulation but not Fas ligand expression was found in the infected PTEC . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
While the fas / fas ligand system has been extensively investigated in immuno competent cells , the place of this system in the physiology and pathophysiology of liver cells remains to be clarified . ^^^ However it is the localization of fas on the plasma membrane of hepatocytes which explains why these cells are mainly destroyed by apoptosis in a picture resembling human fulminant hepatitis when mice are administered with anti fas antibodies or fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Natural killer ( NK ) cell mediated cytotoxicity : differential use of TRAIL and Fas ligand by immature and mature primary human NK cells . ^^^ Mature natural killer ( NK ) cells use Ca2+ dependent granule exocytosis and release of cytotoxic proteins , Fas ligand ( FasL ) , and membrane bound or secreted cytokines ( tumor necrosis factor [ TNF ] alpha ) to induce target cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death . ^^^ In PC 12 cells , deliberate JNK activation is followed by induction of Fas ligand ( FasL ) expression and apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Anti Fas antibody differentially regulates apoptosis in Fas ligand resistant carcinoma lines via the caspase 3 family of cell death proteases but independently of bcl 2 expression . ^^^ To determine if altered Fas mediated cell death pathways participate in epithelial tumorigenesis , we examined squamous cell carcinoma ( SCC ) lines for sensitivity to Fas ligand ( FasL ) or an agonistic anti Fas antibody . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Involvement of Fas / Fas ligand system mediated apoptosis in the development of concanavalin A induced hepatitis . ^^^ Here , we show that development of the disease is completely suppressed in gld / gld mice , in which Fas ligand is defective . ^^^ The data indicate that activation of the Fas / Fas ligand system is a necessary step in the development of Con A induced hepatitis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TNF deficient and B6 . gld mice displayed peptide specific perforin and / or Fas ligand ( FasL ) mediated lysis of E 7 transfected mouse RMA lymphoma cells ( RMA E 7 ) or E 749 57 peptide pulsed RMA S cells , while CD8+ CTL from B6 . perforin deficient mice lysed via FasL exclusively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TNF alpha and IFN gamma render microglia sensitive to Fas ligand induced apoptosis by induction of Fas expression and down regulation of Bcl 2 and Bcl xL . ^^^ Whereas resting microglia are resistant to Fas ligand ( FasL ) treatment , induction of FasL mediated apoptosis was achieved by treatment with TNF alpha or IFN gamma . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TCR stimulated expression of functional Fas ligand was attenuated in a stereospecific manner by NOS inhibitors , but these compounds did not inhibit TCR stimulated IL 2 secretion or CD 69 surface expression . ^^^ Thus , T cells have the capacity to generate NO upon Ag signaling , which may affect signal transduction , Fas ligand surface expression , and apoptotic cell death of mature T lymphocytes . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Together with the observation that S 15 CTL constitutively express Fas ligand , these results indicate that TCR signaling too weak to elicit perforin dependent cytotoxicity or cytokine production can induce Fas dependent cytotoxicity , possibly by translocation of preformed Fas ligand to the cell surface . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To further exclude the possibility of the involvement of the Fas pathway , we treated CC531s cells with recombinant Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL ) , a cell surface molecule belonging to the tumor necrosis factor family , binds to its receptor Fas , thus inducing apoptosis of Fas bearing cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The binding was specific , as it was dramatically reduced by preincubation of the antibody with the Fas peptide used to make it , but not with a Fas ligand ( FasL ) peptide . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Simultaneous expression of Fas and nonfunctional Fas ligand in Ewing ' s sarcoma . ^^^ Fas Fas ligand interactions play a central role in the regulation of the immune response . ^^^ Fas ligand expression by tumors has been implicated in the abrogation of the host antitumor response by killing of Fas positive effector lymphocytes . ^^^ We have studied the presence and functional status of Fas and Fas ligand in Ewing ' s sarcoma . ^^^ With regard to Fas ligand , all cell lines examined were positive for protein by immunoblot , and specificity was confirmed by reverse transcription PCR . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It is possible that p 53 , p 21 , Fas , Fas ligand , and other apoptosis regulating proteins play an important role in the pathophysiology of lung injury and fibrosis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Prolonged survival of rat liver allografts transfected with Fas ligand expressing plasmid . ^^^ BACKGROUND : Transplantation of Fas ligand ( FasL ) gene transfected tissues can have opposite effects . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Detection of TNF alpha and Fas ligand mRNA within synovial mononuclear cells by fluorescence in cell labeling PCR ( FICL PCR ) . ^^^ To learn more about their functional nature , we determined the frequency of synovial T cells that harbored the TNF alpha and Fas ligand transcript by a technique , called Fluorescence In Cell Labeling Polymerase Chain Reaction ( FICL PCR ) . ^^^ D . ) of TNF alpha mRNA positive cells and Fas ligand mRNA positive cells in peripheral blood mononuclear cells from 12 rheumatoid arthritis patients were 5 . 1+ / 2 . 3 % and 4 . 8+ / 3 . 1 % , respectively . ^^^ D . ) of TNF alpha mRNA positive cells and Fas ligand mRNA positive cells among synovial mononuclear cells from six rheumatoid arthritis patients was 16 . 8+ / 8 . 3 % and 10 . 8+ / 1 . 8 % , respectively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The involvement of Fas Fas ligand pathway in fibrosing lung diseases . ^^^ Therefore , we hypothesized that Fas ligand ( FasL ) , which induces apoptosis in cells expressing Fas antigen ( Fas ) , is associated with pulmonary fibrosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer . ^^^ Fas ligand ( FasL ) is produced by activated T cells and natural killer cells and it induces apoptosis ( programmed cell death ) in target cells through the death receptor Fas / Apol / CD95 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The 293 CrmA cells proved to be highly efficient for the construction of recombinant Adv carrying genes encoding Fas and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Induction of fas ligand expression by an acutely lethal simian immunodeficiency virus , SIVsmmPBj 14 . ^^^ In the present study , we examined whether the ability of this virus to cause widespread apoptosis might be linked to the up regulation of Fas ligand ( CD95L ) expression in virally infected cells . ^^^ In vitro studies revealed that expression of the viral Nef protein , in the absence of any other viral gene product , was sufficient to up regulate the transcriptional activity of the CD95L promoter and to cause cell surface expression of Fas ligand . ^^^ Immunohistochemical staining revealed that Fas ligand expression was efficiently up regulated in the GALT of animals that had been experimentally infected with wild type SIVsmmPBj 14 but not in animals that were infected with a nonacutely pathogenic viral mutant lacking the Nef ITAM . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Functional Fas ligand expression on T cells from HIV 1 infected patients is unrelated to CD4+ lymphopenia . ^^^ Here , we show that secretion of Fas ligand ( L ) , the complementary agonist of Fas , is abnormally upregulated in CD4+ cells from HIV 1 infected individuals , particularly during the non lymphopenic stages of the disease . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RORgamma t , a novel isoform of an orphan receptor , negatively regulates Fas ligand expression and IL 2 production in T cells . ^^^ Ectopic expression of RORgamma t protects T cell hybridomas from activation induced cell death by inhibiting the upregulation of Fas ligand . ^^^ We propose that the role of RORgamma t expression in immature thymocytes is to inhibit Fas ligand expression and cytokine secretion following engagement of their TCR during positive or negative selection . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells . ^^^ Fas ligand ( FasL ) triggers apoptosis during cytotoxicity mediated by cytotoxic T lymphocytes and during immune downregulation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : We used competitive template polymerase chain reaction techniques to quantify transcript amounts for the constant region of the T cell receptor beta chain ; the cytokines , tumor necrosis factor alpha , interleukin ( IL ) 1beta , transforming growth factor beta , interferon gamma , IL 2 , IL 4 , IL 10 , and IL 15 ; and the cytotoxic T lymphocyte effector molecules , granzyme B , perforin , and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : Using mice with loss of function mutations in the Fas and Fas ligand ( FasL ) genes ( lpr and gld , respectively ) in transplantation experiments has resulted in contradictory findings concerning the role of Fas / FasL mediated cytotoxicity in allograft rejection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
After GCDC treatment , immunoprecipitation experiments demonstrated Fas oligomerization , and confocal microscopy demonstrated DeltaFADD GFP ( Fas associated death domain green fluorescent protein , aggregation in the absence of detectable Fas ligand mRNA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Elevated serum soluble Fas ligand in natural killer cell proliferative disorders . ^^^ We evaluated the serum level of soluble Fas ligand ( sFasL ) in patients with natural killer lymphocyte proliferative disorders ( NK LPD ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Phagocytosis triggers macrophage release of Fas ligand and induces apoptosis of bystander leukocytes . ^^^ Human monocyte / macrophages ( Mphi ) exposed to nonparticulate stimuli can express cell surface Fas ligand ( FasL ) and release active soluble FasL ( sFasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Gene therapy of experimental autoimmune thyroiditis by in vivo administration of plasmid DNA coding for Fas ligand . ^^^ Fas Fas ligand ( FasL ) interaction is required for the maintenance of immune homeostasis and seems to be responsible for the privileged immune status of some tissues . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunologic escape includes the loss of Fas receptor and the gain of Fas ligand expression . ^^^ Here we demonstrate loss of Fas and gain of Fas ligand expression in the adrenocortical carcinoma cell line NCI H 295 by immunohistochemistry and RT PCR . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Pancreatic cancer cells can evade immune surveillance via nonfunctional Fas ( APO 1 / CD95 ) receptors and aberrant expression of functional Fas ligand . ^^^ BACKGROUND : The Fas ( APO 1 / CD95 ) receptor / Fas ligand ( FasR / FasL ) system plays a key role in immune surveillance . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunohistochemical analysis of Fas ligand expression in sarcomas . ^^^ Fas ligand ( FasL ) and its receptor , Fas , play a key role in the regulation of apoptosis within the immune system . ^^^ Several prior experimental studies of Fas ligand expression in tumors have suggested a mechanism that enables tumors to evade immune destruction by inducing apoptosis in activated lymphocytes near the tumor cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Hypothesizing that loss of basal cells in oral lichen planus is due to apoptosis , we evaluated LP specimens for apoptosis regulating proteins [ positive regulators Bcl xS , Bax , Fas / Fas ligand , p 53 , and negative regulators ( anti apoptotic ) Bcl 2 , Bcl xL and compared results with reactions in normal mucosa and chronically inflamed gingiva . ^^^ Also , no differences in Fas and Fas ligand staining were evident . ^^^ That the Bcl 2 family of proteins and Fas / Fas ligand were detected in normal and diseased tissues , and were occasionally expressed differently in oral LP , supports the notion that apoptosis is a potential mechanism of keratinocyte loss , especially in LP . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A recent report described the expression of Fas ligand ( FasL ) by melanoma cells as an important mechanism involved in the immune evasion by tumors [ M . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A mechanism of autoimmune destruction of islet beta cells in type 1 diabetes has been proposed to be the binding of Fas ligand ( FasL ) on T cells to Fas receptors on beta cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The depletion of macrophages in these mice resulted in a decrease in the Th 1 immune response along with an increase in the Th 2 immune response because of significant decreases in the expression of macrophage derived cytokines , particularly interleukin 12 , and a decrease in beta cell specific T cell activation , as shown by significant decreases in the expression of Fas ligand ( FasL ) , CD 40 ligand ( CD40L ) , and perforin , as compared with control mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Transforming growth factor beta 1 inhibits Fas ligand expression and subsequent activation induced cell death in T cells via downregulation of c Myc . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
As well , there was a deficit in T cell activation , evidenced by significant decreases in the expression of Fas ligand and perforin . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface fas ligand expression and amplifies fas mediated hepatocyte death during allograft rejection . ^^^ We detected increased hepatocyte expression of Fas , Fas ligand ( FasL ) , and CD 40 associated with dropout of centrilobular ( acinar zone 3 ) hepatocytes in chronic allograft rejection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
IL 18 induces gene expression and synthesis of TNF , IL 1 , Fas ligand , and several chemokines . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Apo 1 receptor ( Fas ) , Fas ligand ( Fas L ) and soluble Fas ligand ( sFas L ) are inducers , while soluble Fas ( sFas ) is an inhibitor of apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Gastric cancer cell lines lack Fas ligand ( FasL ) expression but kill T cells via a FasL independent pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Role of Egr 2 in up regulation of Fas ligand in normal T cells and aberrant double negative lpr and gld T cells . ^^^ We previously identified a Fas ligand regulatory element ( FLRE ) in the Fas ligand ( fasL ) promoter that binds Egr family proteins and demonstrated that Egr 3 ( PILOT ) but not Egr 1 ( NGFI A , Krox 24 , Tis 8 , and Zif 268 ) induces transcription of fasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptotic role of Fas / Fas ligand system in the regulation of erythropoiesis . ^^^ The possible involvement of Fas and Fas ligand ( FasL ) in the regulation of erythropoiesis was evaluated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
HO 1 expressed mRNA for apoptosis inducing mediators , including perforin , granzyme B , Fas ligand , TNF alpha , and lymphotoxin ; however , no DNA fragmentation was detected in target cells incubated with HO 1 by 5 [ 125I ] Iodo 2 ' deoxyuridine release assay and agarose gel electrophoresis of DNA . ^^^ Although it has been suggested that the Fas / Fas ligand system is the main pathway by which CD 4 ( + ) CTL mediated cytotoxicity is exerted in murine systems , HO 1 produced peptide specific and HLA restricted cytotoxicity via a Fas independent and nonapoptotic pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fanconi anemia group C gene product modulates apoptotic responses to tumor necrosis factor alpha and Fas ligand but does not suppress expression of receptors of the tumor necrosis factor receptor superfamily . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Positive labeling for Fas ligand was not associated with increased apoptosis of surrounding T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RS cells express several members of the TNF receptor family such as the FAS ligand ( CD95L ) that may induce apoptosis of activated , FAS expressing , CD8+ T cells and NK cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
According to this model , Fas ligand ( FasL ) and Fas , expressed by Sertoli cells and germ cells , respectively , respond to environmental conditions and initiate germ cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
DNA damage signals induction of fas ligand in tumor cells . ^^^ Fas ligand ( FasL ) , a key component of T lymphocytes , has been shown to be induced by some of those agents . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this article , we review current scientific and clinical concepts of apoptosis , including death factors such as Fas ligand and tumor necrosis factor , apoptotic signal transduction mechanisms , and the role of intracellular proteinases called caspases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Fas ligand mRNA are expressed in Helicobacter pylori infected mucosa ] . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased susceptibility of Fas ligand deficient gld mice to Trypanosoma cruzi infection due to a Th 2 biased host immune response . ^^^ Infection of BALB / c mice with Trypanosoma cruzi resulted in up regulated expression of Fas and Fas ligand ( FasL ) mRNA by splenic CD4+ T cells , activation induced CD4+ T cell death ( AICD ) , and in Fas : FasL mediated cytotoxicity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Suppression of Fas receptor and negative correlation of Fas ligand with differentiation and apoptosis in oral squamous cell carcinoma . ^^^ Apoptosis and the expression of Fas receptor ( Fas ) and Fas ligand ( FasL ) were studied in 8 samples of normal oral mucosa ( OM ) and in 19 oral squamous cell carcinomas ( OSCC ) by immunohistochemistry and the TUNEL method . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Induction of specific T cell tolerance by Fas ligand expressing antigen presenting cells . ^^^ Autocrine interaction of Fas and Fas ligand leads to apoptosis of activated T cells , a process that is critical for the maintenance of peripheral T cell tolerance . ^^^ Paracrine interactions of Fas ligand with T cells also may play an important role in the maintenance of tolerance , as Fas ligand can create immune privileged sites and prevent graft rejection by inducing apoptosis in T cells . ^^^ We surmised that APCs that express Fas ligand might directly induce apoptosis of T cells during presentation of Ag to the T cells , thus inducing Ag specific , systemic T cell tolerance . ^^^ Here , we show that profound , specific T cell unresponsiveness to alloantigen was induced by treatment of H 2k mice with H 2b APCs that expressed Fas ligand and that profound T cell unresponsiveness specific for the H Y Ag was induced by treatment of H 2Db / H Y TCR transgenic female mice with H 2Db / H Y APCs that expressed Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand and Fas are expressed constitutively in human astrocytes and the expression increases with IL 1 , IL 6 , TNF alpha , or IFN gamma . ^^^ Fas ligand ( FasL ) and Fas are mediators of apoptosis , which are implicated in the peripheral deletion of autoimmune cells , activation induced T cell death , and cytotoxicity mediated by CD8+ T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand induction in human NK cells is regulated by redox through a calcineurin nuclear factors of activated T cell dependent pathway . ^^^ Fas ligand ( FasL ) on cytotoxic lymphocytes is important for mediating apoptosis of activated lymphocytes and other target cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas Fas ligand antigens and apoptotic marker APO2 . 7 by the human conjunctival epithelium . ^^^ In surface conjunctival epithelial cells the expressions of Fas , Fas ligand , the apoptotic marker APO2 . 7 and of HLA DR class 2 antigen , a membrane marker known to be expressed in inflammatory conditions were investigated . ^^^ Cells were processed for flow cytometry , using monoclonal antibodies to Fas , Fas ligand , APO2 . 7 , HLA DR antigens and a negative isotypic control . ^^^ Fas ligand and APO2 . 7 were variably expressed by conjunctival cells , but in a significantly higher percentage of cells in pathological eyes than in normal ones . ^^^ Highly significant correlations were found between Fas , Fas ligand , APO2 . 7 and HLA DR levels . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Both Fas ligand ( FasL ) and Fas receptor ( Fas ) were expressed postnatally in rat testis with peak expression associated with the high levels of germ cell apoptosis found during the first wave of spermatogenesis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand mediated lysis of erbB 2 expressing tumour cells by redirected cytotoxic T lymphocytes . ^^^ Redirected MD 45 CTL utilised Fas ligand to induce target cell death since soluble Fas Fc fusion protein completely inhibited cytolysis . ^^^ The sensitivity of tumour target cells to Fas ligand was further enhanced by treating them with interferon gamma , a regulator of Fas and downstream signalling components of the Fas pathway . ^^^ Overall , this study has demonstrated the requirement for successful activation of Fas ligand function in conjunction with cytokine treatment for effective lysis of breast carcinoma target cells mediated by redirected CTL . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( CD 95 ) and Fas ligand ( CD95L ) are an interacting receptor ligand pair required for immune homeostasis . ^^^ Fas ( CD 95 ) and Fas ligand ( CD95L ) are an interacting receptor ligand pair required for immune homeostasis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas , Fas ligand , caspase 3 and Bcl 2 were determined by immunohistochemistry . ^^^ Higher expression of the pro apoptic factors Fas , Fas ligand and caspase 3 correlated with a lower incidence of lymph node involvement ( Fas ligand , p=0 . 004 ; caspase 3 , p=0 . 007 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Antitumor effect of allogenic fibroblasts engineered to express Fas ligand ( FasL ) . ^^^ Fas ligand is a type 2 transmembrane protein which can induce apoptosis in Fas expressing cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas and soluble Fas ligand proteins in human milk : possible significance in the development of immunological tolerance . ^^^ This study reports the results of an ELISA based quantitation of soluble Fas and soluble Fas ligand in human milk which may modulate the Fas / FasL system that is critical for the expression of immune tolerance and apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas immunoreactive cells were localized in close proximity to Fas ligand ( FasL ) expressing cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Animals lacking perforin , Fas , Fas ligand , or both perforin and Fas ligand were infected genitally with C . trachomatis MoPn and monitored for expression of immunity to chlamydial antigens and clearance of MoPn from the genital mucosa . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In vitro induction of activation induced cell death in lymphocytes from chronic periodontal lesions by exogenous Fas ligand . ^^^ Lymphocytes from the lesions expressed mRNA encoding Fas , whereas Fas ligand mRNA was very weakly expressed in lymphocytes from the lesions and in periodontal tissues . ^^^ These results indicate that lymphocytes in the lesions are susceptible to activation induced cell death and are induced to die by apoptosis after the addition of exogenous Fas ligand . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Binding of agonistic anti Fas ( APO 1 / CD95 ) antibodies or Fas ligand ( Fas L ) induces apoptosis in some Fas+ leukemias , and anti Fas antibody was originally investigated as a possible therapeutic reagent . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand interaction induces apoptosis in inflammatory myopathies : CD4+ T cells cause muscle cell injury directly in polymyositis . ^^^ OBJECTIVE : To investigate the involvement of the Fas / Fas ligand ( Fas / FasL ) system in the inflammatory myopathies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , in these families , APS was not linked with HLA , Fas , or other candidate genes , including beta 2 glycoprotein 1 , HLA , T cell receptor beta chain , Ig heavy chain , antithrombin 3 , Fas ligand , factor 5 , complement factor H , IgK , and Fas . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Further studies using Fas ligand or specific anti Fas antibody are needed . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble HLA class 1 , HLA class 2 , and Fas ligand in blood components : a possible key to explain the immunomodulatory effects of allogeneic blood transfusions . ^^^ Soluble HLA class 1 ( sHLA 1 ) , HLA class 2 ( sHLA 2 ) , and Fas ligand ( sFasL ) molecules may play immunoregulatory roles . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Following irradiation , Western analysis neither demonstrated any significant alteration in Bcl 2 , p29Bcl xL , p18Bcl xLdelta , or Bax ; nor induced CD 95 ( Fas receptor ) or Fas ligand expression in any cell type . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression in the bone marrow in myelodysplastic syndromes correlates with FAB subtype and anemia , and predicts survival . ^^^ The Fas receptor , Fas ligand ( FasL ) pathway is a major mechanism of apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We show that an influenza hemagglutinin specific CD4+ murine T cell hybridoma ( IP 12 7 ) enters the apoptotic suicide program via the Fas ligand ( FasL ) / Fas mediated pathway upon T cell receptor ( TCR ) stimulation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , the Fas ligand was not expressed in Jurkat cells either before or after treatment with CHX , suggesting that the activation of these caspases does not involve the Fas receptor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of the apoptotic marker Apo 2 . 7 , nuclear antigen p 53 , membrane proteins Fas and Fas ligand , and DNA content was studied by flow cytometry . ^^^ Fas ligand was always negative . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Modulation of caspase 3 activity and Fas ligand mRNA expression in rat liver cells in vivo by alcohol and lipopolysaccharide . ^^^ Caspase 3 activity and Fas ligand mRNA expression were determined in hepatocytes , KCs , and SECs . ^^^ Fas ligand mRNA expression , which had the highest level in SECs , followed by KCs and hepatocytes , was not affected by alcohol administration . ^^^ Lipopolysaccharide had the following effects : an increase in ALT in both pair and alcohol fed rats , and LDH only in alcohol fed rats , a decrease in GSH + GSSG levels in both mitochondria and hepatocytes , an elevation of malondialdehyde content in hepatocytes , a raise in caspase 3 activity in all groups and cell types , and an augmentation of Fas ligand expression in hepatocytes and KCs , but not in SECs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of CD 95 on hematopoietic cells was induced by the type C stroma , however , production of fas ligand by the stromal cells was not observed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand mediated exocrinopathy resembling Sjgren ' s syndrome in mice transgenic for IL 10 . ^^^ Transgenic expression of IL 10 induced apoptosis of glandular tissue destruction and lymphocyte infiltration consisting primarily of Fas ligand ( FasL ) + CD4+ T cells , as well as in vitro up regulation of FasL expression on T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Human CD4+ T cell clones , HK 12 and 4HM1 , exhibited perforin independent and Fas ligand ( FasL ) independent cytotoxicity against certain target cells , including T lymphoma ( Jurkat ) and keratinocyte ( HaCaT ) cell lines , which are susceptible to TRAIL mediated cytotoxicity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Constitutive Fas ligand gene transcription in Sertoli cells is regulated by Sp 1 . ^^^ The transcriptional regulation of the Fas ligand ( FasL ) gene in Sertoli cells was investigated , as these cells are known to have constitutive expression of FasL and hence maintain an `` immune privileged ' ' environment within the testicle . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand independent , FADD mediated activation of the Fas death pathway by anticancer drugs . ^^^ Anticancer drugs have been shown to enhance both Fas receptor and Fas ligand expression on tumor cells . ^^^ The contribution of Fas ligand Fas receptor interactions to the cytotoxic activity of these drugs remains controversial . ^^^ The expression of Fas ligand on the plasma membrane , which is identified in untreated U 937 human leukemic cells but remains undetectable in untreated HT 29 and HCT 116 human colon cancer cell lines , is not modified by exposure to various cytotoxic agents . ^^^ These results suggest that drug induced cell death involves the Fas / FADD pathway in a Fas ligand independent fashion . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Fas ligand interaction in human colorectal hepatic metastases : A mechanism of hepatocyte destruction to facilitate local tumor invasion . ^^^ Our results show that > 85 % of lymphocytes infiltrating colorectal liver cancer express high levels of Fas ligand ( Fas L ) by flow cytometry . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Normal gastric and small bowel tissue express low levels of Fas antigen and nondetectable levels of Fas ligand . ^^^ Consequent to H . pylori infection , there is elevated expression of Fas antigen in mucosal cells concurrent with Fas ligand expressing lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis , Fas and Fas ligand expression in melanocytic tumors . ^^^ Fas binding to its ligand , Fas ligand ( Fas L ) , has been shown to trigger apoptosis in various cell types . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Acceptance of islet allografts transplanted with Fas ligand expressing testicular allografts . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Construction of a recombinant adenovirus vector encoding Fas ligand with a CRE / Loxp inducible system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand messenger ribonucleic acid and protein expression in the rat corpus luteum during apoptosis mediated luteolysis . ^^^ The Fas ( APO 1 / CD95 ) receptor , a transmembrane protein that induces apoptosis in the cell when bound to Fas ligand ( FasL ) , may be involved . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( CD 95 ligand ) controls angiogenesis beneath the retina . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although AS E 2 cells expressed Fas ligand mRNA , treatment with ZB 4 , an antibody that inhibits Fas mediated cell death , failed to suppress IFN gamma or TNF alpha mediated cytotoxicity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
IAV increased neutrophil expression of Fas antigen and Fas ligand , and it also increased release of Fas ligand into the cell supernatant . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Virus infected hepatocytes bear Fas receptors and apoptosis is induced by binding to the Fas ligand which is expressed by activated T cells ; this action is probably mediated by enzymes of the caspase family and / or by granzyme B . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Neuronal and glial cell type specific promoters within adenovirus recombinants restrict the expression of the apoptosis inducing molecule Fas ligand to predetermined brain cell types , and abolish peripheral liver toxicity . ^^^ Gene therapy using Fas ligand ( FasL ) for treatment of tumours and protection of transplant rejection is hampered because of the systemic toxicity of FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The different susceptibility to AICD between Th 1 and Th 2 cells was not due to their differential expression levels of PMA sensitive PKC isoforms but appeared to be due to their differential requirement for PMA sensitive isoforms in the up regulation of Fas ligand which is involved in suicide killing of activated Th 1 cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis resistant T cells have a deficiency in NF kappaB mediated induction of Fas ligand transcription . ^^^ Apoptosis induced through the TCR in CD4+ T cells is mostly mediated by the inducible expression of Fas ligand ( FasL ) as a primary event leading to the commitment to death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Contrary to the prevailing view that tumor cells cause the death of anti tumor T cells by expressing Fas ligand ( FasL ) , our data suggested that FasL was instead expressed by T lymphocytes upon activation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas ligand is chemotactic for human neutrophilic polymorphonuclear leukocytes . ^^^ It has been recently shown that Fas ligand ( FasL ) expression on islet beta grafts results in neutrophilic infiltration and graft rejection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Temporal sequence of transcription of perforin , Fas ligand , and tumor necrosis factor alpha genes in rejecting skin allografts . ^^^ BACKGROUND : Perforin , Fas ligand ( FasL ) , and tumor necrosis factor alpha ( TNF alpha ) have been implicated in cytolytic T lymphocyte ( CTL ) effector function . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand are expressed in the uteroplacental unit of first trimester pregnancy . ^^^ PROBLEM : Fas and Fas ligand ( FasL ) are thought to provide a strategy for reducing graft rejection in immunologically ' privileged ' tissues by controlling injurious lymphocyte reactions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Colorectal carcinoma cells have recently been shown to express Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Elaboration of aptogenic cytokines such as TNF alpha and IL 1beta may reinforce this sequence by up regulating cellular expression of fas ligand and its cognate receptor , suppressing responsiveness to growth factor stimulation , and accelerating apoptotic cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of apoptotic regulatory molecules in renal cell carcinoma : elevated expression of Fas ligand . ^^^ The present study has therefore determined the expression of Fas ( APO 1 / CD95 ) , Fas ligand ( Fas L ) and bcl 2 in these tumours . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Within the nucleus , FKHRL 1 triggers apoptosis most likely by inducing the expression of genes that are critical for cell death , such as the Fas ligand gene . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Does Fas ligand or endotoxin contribute to thymic apoptosis during polymicrobial sepsis . ^^^ However , reports also suggest that these steroid effects could be mediated by Fas ligand ( FasL ) and / or by endotoxin ( ETX ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Negative regulation of inflammation by Fas ligand expression on the vascular endothelium . ^^^ Recently , we reported that vascular endothelial cells ( ECs ) express Fas ligand , which functions to actively inhibit inflammation by inducing apoptosis in Fas bearing leukocytes . ^^^ The inflammatory cytokine TNF alpha downregulates Fas ligand expression with an accompanying decrease in EC cytotoxicity toward Fas bearing cells in co culture . ^^^ Endothelial Fas ligand expression in arteries is also downregulated by the local administration of TNF alpha , and this correlates with robust mononuclear cell infiltration of the subendothelial space . ^^^ This TNF alpha induced mononuclear cell infiltration is inhibited by pre infecting the endothelium with a replication defective adenovirus that constitutively expresses Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tumor cells may also become resistant to mediators of apoptosis , such as Fas ligand and tumor necrosis factor related apoptosis inducing ligand used by lymphocytes to kill tumor cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Three patients with different clinical symptoms of graft versus host disease ( GVHD ) who had received donor lymphocyte transfusion ( DLT ) for the treatment of relapsed leukaemia after an allogeneic bone marrow transplantation ( BMT ) from HLA matched sibling donors were analysed for the presence of soluble FasL ( sFasL ) in the sera and for the expression of the Fas ligand ( FasL ) gene in the peripheral blood mononuclear cells ( PBMNC ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Epithelial to stromal interactions are mediated by cytokines , such as interleukin 1 ( IL 1 ) and soluble Fas ligand , that are released by corneal epithelial cells in response to injury . ^^^ The Fas / Fas ligand system has been shown to contribute to the immune privileged status of the cornea . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the present study , we examined the contribution of cytotoxic effector mechanisms , which are mediated by tumor necrosis factor alpha ( TNF alpha ) , Fas ligand ( FasL ) , or perforin , to GVHD and GVL effect in a murine BMT model . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Adenovirus mediated delivery of fas ligand inhibits intimal hyperplasia after balloon injury in immunologically primed animals . ^^^ Here , we explored the efficacy of adenovirus mediated transfer of Fas ligand , a cytotoxic gene with immunomodulatory properties , in inhibiting injury induced vascular lesion formation in both naive and immunologically primed animals . ^^^ METHODS AND RESULTS : Lesion formation was evaluated in balloon injured carotid arteries of naive and adenovirus immunized rats that were infected with adenoviral constructs expressing Fas ligand ( Ad FasL ) , the cyclin dependent kinase inhibitor p 21 ( Ad p 21 ) , or beta galactosidase ( Ad betagal ) . ^^^ CONCLUSIONS : Our data demonstrate that adenovirus mediated Fas ligand delivery can inhibit intimal hyperplasia in both immunologically primed and naive animals , whereas the efficacy of an adenovirus mediated p 21 delivery is limited to immunologically naive animals . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Enhanced expression of fas ligand ( CD95L ) on T cells after segmental allergen provocation in asthma . ^^^ OBJECTIVE : Because signals delivered through Fas / Fas ligand can lead to T cell apoptosis , we investigated the expression of Fas and Fas ligand on peripheral blood and bronchoalveolar lavage fluid ( BALF ) derived T cells and the percentage of apoptotic BALF cells in asthma . ^^^ Flow cytometry was used to determine the T cell expression of Fas and Fas ligand , and the terminal dUTP nick end labeled technique was applied to detect apoptotic BALF cells . ^^^ A small percentage of T cells in BALF expressed the Fas ligand . ^^^ In asthmatic subjects , but not in control subjects , there was a significant increase in Fas ligand after allergen challenge ( CD 3 : 0 . 8 % + / 0 . 6 % [ baseline ] vs 3 . 2 % + / 1 . 2 % [ allergen challenge ] ; CD 4 : 1 . 8 % + / 0 . 0 % vs 4 . 3 % + / 1 . 8 % ; CD 8 : 2 . 8 % + / 2 . 4 % vs 9 . 1 % + / 4 . 8 % ) but not after saline challenge , with a significant correlation to the percentage of BALF eosinophils . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Co expression of Fas and Fas ligand on the surface of influenza virus infected cells . ^^^ By flow cytometry , cell surface Fas ligand was detected in virus infected cells with a time course similar to that of Fas . ^^^ Moreover , Fas and Fas ligand were co expressed in those cells . ^^^ In fact , apoptosis of the virus infected cells was inhibited in the presence of an antagonistic anti Fas ligand monoclonal antibody . ^^^ These results suggest that influenza virus infection causes augmented expression of both Fas and Fas ligand and apoptosis is induced when the infected cells come into contact with each other . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We show here that human and rat colon cancer cells undergo massive apoptosis when they are exposed to soluble Fas ligand in the presence of sodium butyrate , an agent that induces by itself only a low rate of apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptotic cell death , induced by the ligation of Fas ( APO 1 / CD95 ) with Fas ligand ( FasL / CD95L ) may be an explanation for the tissue damage seen in SS . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Though expression of Fas / Apo 1 ( CD 95 ) and Fas ligand ( FasL ) was detected on RNA and protein level we found Fas / Apo 1 mediated apoptosis being significantly reduced . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , Fas levels and Fas ligand dependant killing were both markedly reduced in the mutant clone . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Adenovirus mediated expression of Fas ligand induces apoptosis of human prostate cancer cells . ^^^ We have re evaluated the apoptotic potentials of seven human PC cell lines using the natural Fas ligand ( FasL ) in place of agonistic antibody . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The phorbol ester stimulated THP 1 cells also expressed increased levels of the pro apoptotic gene products , caspase 3 and Fas ligand , but the cells exhibited no change in apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recently , we detected functional Fas ligand ( FasL ) expression on the endothelial lining of blood vessels . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVES : The Fas / APO 1 is a cell surface receptor protein known to trigger apoptosis when conjugated with Fas ligand or specific agonistic antibodies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Aberrant CD 3 and CD 28 mediated signaling events in cord blood T cells are associated with dysfunctional regulation of Fas ligand mediated cytotoxicity . ^^^ Dual stimulation of peripheral blood TCs ( PBTCs ) and bone marrow TCs ( BMTCs ) with mAbs to CD 3 and CD 28 induced expressions of Fas ligand ( FasL ) , as well as CD 25 and CD 154 ( CD40L ) , whereas defective induction of these activation associated cell surface molecules were observed in CBTCs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We found that the hepatitis in this mouse reflects human chronic hepatitis at least in the following points , 1 ) infiltration by lymphoid cells into the portal areas and necroinflammation in the lobules , and 2 ) expression of Fas antigen and Fas ligand mRNAs in the liver . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Abnormal proliferation of CD 4 CD8+ gammadelta+ T cells with chromosome 6 anomaly : role of Fas ligand expression in spontaneous regression of the cells . ^^^ Sorted gammadelta+ T cells showed an increase in Fas ligand expression compared with the levels in sorted alphabeta+ T cells . ^^^ The expression of Fas ligand on these gammadelta+ T cells increased after IL 2 stimulation . ^^^ The expression of Fas ligand may be involved in spontaneous regression of granular lymphocyte proliferation with hemolytic anemia . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The role of CD8+ cells , cell degeneration , and Fas ligand in insulitis after intraperitoneal transfer of NOD splenocytes . ^^^ Fas ligand was not present in Western blotting . ^^^ It is proposed that apoptosis commonly occurs in islet infiltrating lymphocytes and that in the scid / scid adoptive transfer model , the first islet infiltrating cells are destroyed by programmed cell death independent of Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Death receptor Fas transduces cell death signaling upon stimulation by Fas ligand , and this death signaling is mediated by caspase . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These data suggest that the Fas response is specifically inactivated by unknown mechanisms to avoid autocrine or paracrine killing by Fas ligand constitutively expressed on neighboring cyto or syncytiotrophoblasts . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Dual role for Fas ligand in the initiation of and recovery from experimental allergic encephalomyelitis . ^^^ We have previously demonstrated a role for Fas and Fas ligand ( FasL ) in the pathogenesis of experimental allergic encephalomyelitis ( EAE ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A critical role for Fas ligand in the active suppression of systemic immune responses by ultraviolet radiation . ^^^ In this report , we document that Fas ligand ( FasL ) is critical for UV induced systemic immune suppression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The results presented here demonstrate that human monocytes rapidly express TRAIL , but not Fas ligand or TNF , after activation with interferon ( IFN ) gamma or alpha and acquire the ability to kill tumor cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Functional expression of Fas and Fas ligand on human intestinal intraepithelial lymphocytes . ^^^ Fas ( CD95 / APO 1 ) is a surface receptor that induces apoptotic cell death upon ligation with Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression in primary colon adenocarcinomas : evidence that the Fas counterattack is a prevalent mechanism of immune evasion in human colon cancer . ^^^ Fas ligand ( FasL ) kills sensitive Fas receptor ( FasR ) bearing cells by inducing apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The percentages of cells expressing Fas receptor and / or Fas ligand varied between large ranges in both tumor and ANRC , thus suggesting that other mechanisms are also involved in the activation of apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Involvement of the Fas / Fas ligand system in p 53 mediated granulosa cell apoptosis during follicular development and atresia . ^^^ In the present study we have examined the presence of Fas , Fas ligand ( FasL ) , and p 53 in rat granulosa cells during follicular development and atresia , especially in relation to the granulosa cell cycle progression and the onset of granulosa cell apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis and the expression of Fas and Fas ligand ( FasL ) antigen in rejection and reinfection in liver allograft specimens . ^^^ BACKGROUND AND METHODS : To investigate the frequency of apoptosis and the expression of Fas / Fas ligand ( FasL ) in liver allografts , we examined 97 biopsy specimens from 62 patients after orthotopic liver transplantation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain . ^^^ Much of this apoptosis is mediated by Fas Fas ligand ( FasL ) interactions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Extracellular signals , such as various growth factors and antigen Fas ligand can trigger apoptosis via cell surface receptors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand ( FasL ) have been found both in lymphoid and in non lymphoid malignancies , and are thought to play a role in the interplay between tumors and the immune system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Perforin independent CD 8 ( + ) T cell mediated cytotoxicity of alveolar epithelial cells is preferentially mediated by tumor necrosis factor alpha : relative insensitivity to Fas ligand . ^^^ The primary effector function of this T cell subset is cytolysis of virus infected cells , and it is widely believed that there are two primary molecular mechanisms by which this occurs : the perforin / granzyme mediated pathway of cytolysis , and the Fas ligand ( FasL ) Fas ( CD95 / APO 1 ) pathway of induction of target cell apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Two cytotoxic mechanisms of CTL have been demonstrated : one perforin / granzyme based and the other Fas ( CD 95 ) / Fas ligand ( FasL ) based . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activation induced cell death of peripheral T cells results from the interaction between Fas and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RT PCR and FACS analyses revealed the expression of CD 95 ( Fas ) by XS 52 DC and of CD 95 ligand ( CD95L ) ( Fas ligand ) by activated HDK 1 T cells , suggesting a functional role for these molecules . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Moreover , the anti metastatic effect of IL 12 was abrogated by perforin deficiency , but not by Fas ligand deficiency , in association with a lack of IL 12 induced cytotoxic activity of liver and splenic mononuclear cells against B 16 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Regulation of Fas ligand expression and cell death by apoptosis linked gene 4 . ^^^ One of the best understood apoptotic pathways occurs in T lymphocytes and is mediated by Fas / Fas ligand ( FasL ) interaction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
HSV specific CD4+ CTLs generated from lymphocytes of the patient and her mother exerted cytotoxicity against HSV infected cells from the patient ( Fas / ) and from her mother ( Fas+ / ) to almost the same degree in an HLA class 2 restricted manner . mRNAs for the major mediators of CTL cytotoxicity , Fas ligand , perforin , and granzyme B , were detected in these CD4+ CTLs using the RT PCR and flow cytometry . ^^^ Although the Fas / Fas ligand system has been reported to be the most important mechanism for CD4+ CTL mediated cytotoxicity in the murine system , the present findings strongly suggest that granule exocytosis , not the Fas / Fas ligand system , is the main pathway for the cytotoxicity mediated by HSV specific human CD4+ CTLs . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Sixteen seminomas with surrounding tissue containing normal and precancerous ( cis ) seminiferous tubules were examined for the expression of Fas ( CD 95 , APO 1 ) and Fas ligand ( FasL ) ( CD95L ) . ^^^ Fas and Fas ligand expression in seminomatous testes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Transitional cell carcinoma expresses high levels of Fas ligand in vivo . ^^^ OBJECTIVE : To characterize the Fas Fas ligand system , a main apoptotic pathway , in transitional cell carcinoma ( TCC ) of the urinary bladder , by analysing the expression of Fas and Fas ligand ( FasL ) in TCC samples . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Variations in cytolytic activities and mRNA expression of perforin , granzyme B and Fas ligand ( FasL ) were observed in U 5 CD16+ CD56+ cells depending on the donor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( APO 1 ; CD 95 ) and Fas ligand ( FasL ) mediate apoptosis induced by IFNgamma , because Fas is significantly upregulated by IFNgamma , whereas Fas ligand is constitutively present in the ECFC and neutralization of FasL greatly reduces the apoptosis . ^^^ Fas ( APO 1 ; CD 95 ) and Fas ligand ( FasL ) mediate apoptosis induced by IFNgamma , because Fas is significantly upregulated by IFNgamma , whereas Fas ligand is constitutively present in the ECFC and neutralization of FasL greatly reduces the apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here , we demonstrate that TR 6 specifically binds two cellular ligands , LIGHT ( herpes virus entry mediator ( HVEM ) L ) and Fas ligand ( FasL / CD95L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The death receptor Fas transduces apoptotic death signaling upon stimulation by Fas ligand and plays a key role in viral hepatitis . ^^^ When hepatitis B virus ( HBV ) infects hepatocytes , the Fas ligand / Fas system responds as the triggering machinery of hepatitis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand , Fas antigen and Bcl 2 expression in human endometrium during the menstrual cycle . ^^^ In this study , we investigate Fas ligand expression in the human endometrium during the menstrual cycle in relation to Fas antigen and Bcl 2 expression , using immunoelectron microscopy and Western blotting . ^^^ The Fas ligand , as well as the Fas antigen , were expressed on the surface of endometrial glandular cells throughout the menstrual cycle , whereas Bcl 2 showed a cyclic expression pattern , peaking during the late proliferative phase . ^^^ A noteworthy finding was that both the Fas ligand and the Fas antigen were localized on Golgi apparatuses and vesicles , in addition to the cell membranes , during the late proliferative phase . ^^^ These results indicate that the Fas ligand and Fas antigen which are localized on Golgi apparatus and vesicles during the late proliferative phase are incorporated into the cell membranes during the secretory phase , and are co expressed on the cell membranes of endometrial glands throughout the menstrual cycle . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The failure of mature CD 8 cells to simultaneously engage their TCR and CD 8 coreceptor triggers an activation process that begins with inhibition of CD 8 gene expression through remethylation and concludes with up regulation of surface Fas and Fas ligand and cellular apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand expression in tumor cells and in vascular smooth muscle cells of colonic and renal carcinomas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Employing these molecular processes in the treatment of RA , we have recently shown that ex vivo gene transfer of human Fas ligand ( hFasL ) induced apoptosis of synoviocytes and infiltrated mononuclear cells of RA synovial tissue through cell to cell interaction via the Fas / FasL system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 4 ( + ) T cells are unique in their ability to commit `` suicide ' ' by stimulating their own Fas receptors with secreted or membrane bound Fas ligand . ^^^ T cells can also trigger apoptosis in B cells , macrophages , and other cell types through Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Transplantation of cells and tissues expressing Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Endothelial expression of Fas ligand in transgenic rats under the temporal control of a tetracycline inducible system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Overexpression of Fas ligand does not confer immune privilege to a pancreatic beta tumor cell line ( betaTC 3 ) . ^^^ BACKGROUND : Fas ligand ( Fas L ) is thought to provide immune privilege to specific tissues and tumors by inducing an apoptotic signal of cytotoxic T cells expressing its Fas receptor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunohistochemical staining for TNFalpha , Fas , and Fas ligand ( Fas L ) was performed . ^^^ This upregulation may be due to release of neuroblastoma derived Fas ligand into the media . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Elevated circulating levels and cardiac secretion of soluble Fas ligand in patients with congestive heart failure . ^^^ The circulating levels of soluble Fas ligand was increased in patients with advanced congestive heart failure . ^^^ This study also indicates that the failing heart may contribute to the increased concentration of soluble Fas ligand in patients with congestive heart failure . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ceramide has been known as an important second messenger in programmed cell death ( apoptosis ) which is induced by various stimuli such as the tumor necrosis factor alpha ( TNF alpha ) , Fas ligand , and environmental stresses such as UV irradiation and heat shock . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas and Fas ligand in Hodgkin ' s disease . ^^^ Fas and Fas ligand expression were investigated in twenty two cases of classical Hodgkin ' s disease ( HD ) by immunohistochemistry . ^^^ While Reed Sternberg ( RS ) cells in 7 / 22 ( 32 % ) cases expressed Fas ligand , reactive lymphoid cells expressed Fas ligand in only 2 ( 9 % ) cases . ^^^ Most of these activated T cells expressed Fas but were negative for Fas Ligand . ^^^ To investigate the co expression of Fas and Fas Ligand in the RS cells , six cases were subjected to Fas and Fas ligand immunostaining on consecutive sections . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Unlike VSMC , the same level of increment of the [ Na+ ] i / [ K+ ] 1 ratio caused by a 2 h preincubation of Jurkat cells with ouabain did not affect chromatin cleavage and Caspase 3 activity triggered by treatment with Fas ligand , staurosporine , or hyperosmotic shrinkage . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Restimulation of Ag receptors on peripheral T lymphocytes induces tyrosine phosphorylation based signaling cascades that evoke Fas ligand expression and induction of Fas mediated programmed cell death . ^^^ Enhanced apoptosis of TCR restimulated mev lymphocytes was associated with marked increases in Fas ligand expression as compared with wild type cells , but was almost abrogated in both mev and wild type cells by Fas Fc treatment . ^^^ Thus , the increased sensitivity of mev T cells to apoptosis following TCR restimulation appears to reflect a TCR driven phenomenon mediated through up regulation of Fas Fas ligand interaction and induction of the Fas signaling cascade . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To determine whether Fas or Fas ligand ( FasL ) plays a role in susceptibility to experimental autoimmune encephalomyelitis ( EAE ) , we bred a TCR transgenic mouse specific for the Ac 1 11 peptide of myelin basic protein to mice with inactivating mutations in Fas ( lpr ) or FasL ( gld ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand mutant gld mice displayed uncompromised protection against tumor metastasis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Endogenous factors also exist which induce active cell death ; these include transforming growth factor beta 1 , CD 95 or Fas ligand and tumour necrosis factor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Constitutive expression of Fas ligand ( Fas L ) was found in the basal layer of the normal esophageal mucosa and in IEUs and cytomegalovirus ulcerations . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We used rat models to investigate the expression of Fas / Fas ligand and apoptosis related proteins during liver allograft rejection . ^^^ The expression of Fas ligand mRNA in the allografts which rose on day 5 was 10 times stronger compared to that in the isografts . ^^^ The immunohistochemical analysis also showed an increased reactivity of Fas ligand on day 5 in the allograft , which was observed both in parenchymal and nonparenchymal cells . ^^^ CONCLUSIONS : These results strongly suggest that Fas / Fas ligand interaction mediates the liver injury during allograft rejection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Apo 1 ( CD 95 ) Fas ligand ( FasL ) system has been implicated in the suppression and stimulation of immune responses . ^^^ Fas / Apo 1 ( CD 95 ) Fas ligand ( FasL ) system has been implicated in the suppression and stimulation of immune responses . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The role of Fas ligand ( FasL ) molecule in HFRPE mediated apoptosis was assessed by using a mutant Jkt cell line ( DD 3 ) , which is deficient in Fas mediated signaling . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The ATP depleted cells display a significant upregulation of Fas , Fas ligand , and the Fas associating protein with death domain ( FADD ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Bacterial translocation and systemic endotoxemia have been reported after a burn injury , and caspase 3 activation due to TNF alpha and Fas ligand ( FasL ) are presumed to initiate apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVE : To obtain the apoptosis in MT 2 cells induced by HepG2 . 2 . 15 cells expressing Fas Ligand . ^^^ The cells expressed Fas antigen was added to HepG2 . 2 . 15 cells expressing Fas Ligand together with fresh RPMI 1640 medium and incubated for 48 72 hours at 37 degrees C . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Defective Fas mediated apoptosis in mice , caused by the gld mutation in the fas ligand gene , results in the development of lupus like autoantibodies and severe lymphoproliferation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ( CD95 / APO 1 ) and Fas ligand in lung cancer , its prognostic and predictive relevance . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We asked whether interleukin 18 ( IL 18 ) , which strongly induces IFN gamma and regulates Fas ligand ( Fas L ) dependent cytotoxicity , may play a role in colon homeostasis , and if its expression was modulated in colon adenocarcinomas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Placental Fas ligand expression is a mechanism for maternal immune tolerance to the fetus . ^^^ Fas ligand ( FasL ) is a peptide that plays an important immunoregulatory role in limiting the host immune response . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Inhibition of peripheral blood lymphocyte apoptosis by soluble fas ligand in patients with hepatocellular carcinoma . ^^^ We monitored apoptosis of peripheral blood lymphocytes ( PBL ) obtained from patients with various degrees of chronic viral hepatitis , including hepatocellular carcinoma ( HCC ) , in vitro and quantitated the serum levels of soluble Fas ligand ( FasL ) by ELISA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Co treatment did not significantly alter Bcl 2 , Bcl xL , Bax or Fas receptor ( FasR ) , but modestly increased Fas ligand ( FasL ) protein . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Clinical implications of circulating soluble Fas and Fas ligand in patients with acute myocardial infarction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas system has been implicated as a possible key regulator of apoptosis in various cells : binding of Fas ligand ( FasL ) , a type 2 transmembrane protein , to Fas , a type 1 transmembrane receptor protein , triggers apoptosis in cells expressing Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Treatment with PMA plus ionomycin ( P / I ) results in the upregulation of Fas Ligand ( FasL ) and induction of apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Macrophage derived growth factors modulate Fas ligand expression in cultured endometrial stromal cells : a role in endometriosis . ^^^ Fas Fas ligand ( FasL ) interactions play a significant role in the immune privilege status of certain cell populations , and several cytokines and growth factors can modulate their expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of Fas ligand has recently been proposed as a novel tumor escape mechanism for melanoma . ^^^ To establish the characteristics of Fas ligand expression during the course of melanoma progression we performed a longitudinal study analyzing primary tumors as well as subsequently evolving metastases . ^^^ In primary melanoma Fas ligand was expressed in two of 20 lesions ; this expression was weak and restricted to few parts of the tumors . ^^^ The Fas ligand positive primary melanomas were rather thick , i . e . , 8 . 5 and 3 . 8 mm , versus a median of 2 . 4 mm of the remaining tumors . ^^^ In contrast , for metastatic melanoma Fas ligand expression was present in six of 11 cases investigated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although Fas ligand ( FasL ) protein was expressed in white matter tissue of both systems , it was more pronounced in the CNS . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND AND OBJECTIVES : Fas ( APO 1 ) induces apoptosis after binding Fas ligand ( FasL ) . ^^^ Irradiation induced up regulation of Fas in esophageal squamous cell carcinoma is not accompanied by Fas ligand mediated apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We have hypothesized that HCMV infection might directly or indirectly result in upregulation of Fas receptor and in the presence of Fas ligand , lead to apoptosis of infected cells . ^^^ IFN gamma , in addition to its intrinsic antiviral activity , primes HCMV infected cells to the action of Fas ligand and Fas mediated apoptosis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL ) induces apoptotic death of activated lymphocytes that express its cell surface receptor , FasR ( CD95 / APO 1 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
IkappaBalphaM significantly sensitized mesangial cells to TNF alpha induced apoptosis in a dose and time dependent manner but had no significant effects on the level of apoptosis in the presence of proinflammatory or apoptosis inducing stimuli including Fas ligand , IL 1alpha , IL 1beta , hydrogen peroxide , lipopolysaccharide , cycloheximide , or serum deprivation . ^^^ These data show that inhibition of NF kappaB selectively sensitizes primary adult glomerular mesangial cells to TNF induced apoptosis but not to other mediators of cell death including the Fas ligand . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Essential roles of the Fas Fas ligand pathway in the development of pulmonary fibrosis . ^^^ The Fas ligand is predominantly expressed in activated T lymphocytes and is one of the major effector molecules of cytotoxic T lymphocytes and natural killer cells . ^^^ Previously , we found excessive apoptosis of epithelial cells and infiltrating lymphocytes expressing Fas ligand mRNA in the lung tissue of bleomycin induced pulmonary fibrosis in mice . ^^^ Here we demonstrated that the administration of a soluble form of Fas antigen or anti Fas ligand antibody prevented the development of this model and that lpr and gld mice were resistant against the induction of pneumopathy . ^^^ These results suggest that the Fas Fas ligand pathway plays an essential role in the development of pulmonary fibrosis and that preventing this pathway could have therapeutic value in lung injury and fibrosis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The levels of Fas ligand ( FasL ) mRNA expression in the liver were also decreased by anti CCR 5 antibody treatment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The induction of apoptosis was attempted by incubation with Fas antibody IgM and IgG , Fas ligand and with ceramide . ^^^ However , propidium iodide staining in FACS showed that neither incubation with the Fas antibody nor with the Fas ligand resulted in convincing apoptosis of the neuroblastoma cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Differential antitumor effects of administration of recombinant IL 18 or recombinant IL 12 are mediated primarily by Fas Fas ligand and perforin induced tumor apoptosis , respectively . ^^^ Since IL 18 enhances Fas ligand ( FasL ) expression on NK cell lines , the IL 18 antitumor effects could be mediated by FasL induced cross linking of Fas and subsequent tumor apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interestingly , apoptosis induced by NF kappa B suppression , in contrast to that induced by TPEN ( N , N , N ' , N ' tetrakis [ 2 pyridylmethyl ] ethylenediamine ) or soluble Fas ligand ( CD 95 ) , was observed in the absence of active death effector proteases caspase 1 like ( IL 1 converting enzyme ) , caspase 3 like ( CPP32 / Yama / apopain ) , and caspase 6 like and without cleavage of caspase 3 substrates poly ( ADP ribose ) polymerase and DNA fragmentation factor 45 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We report the preferential expression of Fas on CD4+ T cells and Fas ligand ( FasL ) on monocytes and their potential role in the selective loss of CD4+ T cells in breast cancer patients undergoing high dose chemotherapy and peripheral blood stem cell transplantation ( PSCT ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , Fas ligand expression had never been explored in vivo in tumor cell models yielding either immune response or tolerance . ^^^ In the present study , we analyzed the expression and function of Fas ligand in 2 clones of tumor cells originating from the same rat colon carcinoma . ^^^ Fas ligand was expressed on the plasma membrane of both REGb and PROb cells , and its cDNA sequencing showed no mutation . ^^^ Our results show that surface expression of Fas ligand by tumor cells does not always induce killing of adjoining Fas sensitive cells and that tumor cells may induce a protective immune response or an active tolerance independently of Fas ligand expression . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Applying RT PCR , Western blots , and immunocytochemistry , we have demonstrated expression of the apoptosis inducing protein Fas ligand on astrocytes and neurons of apparently normal rat and human brains . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , results from several laboratories indicate that at least three additional features of the corneal graft contribute to its immune privileged status : ( a ) absence of donor derived , antigen presenting passenger Langerhans cells in the corneal graft ; ( b ) expression of Fas ligand on the epithelium and endothelium of the corneal allograft ; and ( c ) capacity of the corneal allograft to induce immune deviation of the systemic immune response . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cisplatin induced apoptosis in human proximal tubular epithelial cells is associated with the activation of the Fas / Fas ligand system . ^^^ The role of Fas and Fas ligand ( Fas L ) in the apoptotic cell death process in cisplatin ( CP ) treated human proximal tubular epithelial cells ( PTECs ) was examined . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
AIMS : To investigate which of the two most investigated inductors of apoptosis ( Fas ligand ( FasL ) and tumour necrosis factor alpha ( TNF alpha ) ) is responsible for the induction of apoptosis in this animal model . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of fas ligand in human hepatoma cell lines : role of hepatitis B virus 10 ( HBX ) in induction of Fas ligand . ^^^ It has been postulated that tumor cells expressing Fas ligand ( FasL ) can evade immune surveillance by inducing apoptosis in T cells expressing Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Relationship between Fas ligand expression on carcinoma cell and cytotoxic T lymphocyte response in lymphoepithelioma like cancer of the stomach . ^^^ The Fas / Fas ligand ( Fas L ) system is involved in the induction of apoptosis and mediates T cell cytotoxicity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The role of placental Fas ligand in maintaining immune privilege at maternal fetal interfaces . ^^^ Over the last several years our group and others have formulated a hypothesis that trophoblast Fas ligand ( FasL ) plays an important role in maintaining fetal immune privilege in human pregnancy by actively promoting apoptosis ( programmed cell death ) of activated maternal lymphocytes bearing Fas ( i . e . , the FasL receptor ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Despite expressing both Fas and Fas ligand , DU 145 and LNCaP prostate cancer cells were resistant to anti Fas induced cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Extracted cells were labelled with antibodies to T cells , CD11b / c ( macrophages / microglia ) , CD 95 ( Fas ) and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Murine renal tubular epithelial cells and interstitial fibroblasts may express both Fas ( CD 95 ) death receptor and Fas ligand and are vulnerable to Fas mediated death in vitro . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVE : Murine models ( MRL / gld / gld mice ) and recent evidence in humans suggest a possible role of Fas and Fas ligand ( Fas L ) germline mutations in the pathogenesis of autoimmune related lymphoproliferation , including adult cases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TNF and Fas ligand induce apoptosis in tumor cells ; however , their severe toxicity toward normal tissues hampers their application to cancer therapy . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These encode amino acid substitutions that decrease caspase activity and interfere with death receptor induced apoptosis , particularly that stimulated by Fas ligand and TRAIL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of perforin mRNA was constitutive and was unaffected by the cytokines ; however , Fas ligand ( FasL ) mRNA expression was strong in cultures with IL 18 alone or combined with IL 10 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) and Fas ligand ( FasL ) have been implicated in the pathogenesis of graft versus host disease ( GVHD ) , which is a major complication after allogeneic bone marrow transplantation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cutting edge : RANTES regulates Fas ligand expression and killing by HIV specific CD 8 cytotoxic T cells . ^^^ Based on the previous observation that RANTES mediates the cytotoxic activity of human HIV specific CD8+ T cells via the chemokine receptor CCR 3 , we studied the effect of this chemokine on different effector CD8+ cytolytic cells requiring Fas / Fas ligand ( FasL ) or perforin dependent pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Mouse thymocytes were induced to apoptosis by cross linked recombinant soluble human Fas ligand both in vitro and in vivo , though human thymocytes were also resistant to this mode of receptor ligation . ^^^ Membrane bound Fas ligand also induced apoptotic death in murine thymocytes but not in human thymocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activated human T cells release bioactive Fas ligand and APO 2 ligand in microvesicles . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We further showed that the resistance to AICD in primed T cells was due to the decreased sensitivity to apoptosis induced by Fas mediated signals , but TCR mediated signaling equally activated both naive and primed T cells to induce Fas and Fas ligand expressions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
N monomethyl L arginine ( L NMA ) , a NOS inhibitor , partially inhibited NK cell lysis of four different target cells ( < 40 % inhibition at 500 microM L NMA ) , but not granule release following coculture with target cells , or Fas ligand induction following cross linking with anti CD 16 mAb . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To address this , pancreatic islets from NOD mice were analyzed by flow cytometry to directly identify which cells express Fas and Fas ligand ( FasL ) ex vivo and after in vitro culture with cytokines . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , all investigated pancreatic cancer cell lines and cancer specimens expressed Fas ligand . ^^^ Fas ligand was functional in cancer cell lines as shown by coculture assays of pancreatic cancer cell lines with Jurkat cells as targets . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas and Fas ligand on mouse renal tubular epithelial cells in the generalized shwartzman reaction and its relationship to apoptosis . ^^^ The expression of Fas and Fas ligand was immunohistochemically detected on renal tubular epithelial cells from GSR induced mice , although neither Fas nor Fas ligand was found in cells from untreated control mice or in cells from mice receiving a single injection of LPS . ^^^ GSR induced renal tubular epithelial cell injury was produced in neither Fas negative MRL lpr / lpr mice nor Fas ligand negative MRL gld / gld mice . ^^^ The administration of anti gamma interferon antibody together with a preparative injection of LPS prevented the expression of Fas and Fas ligand and the apoptosis of renal tubular epithelial cells . ^^^ A provocative injection of tumor necrosis factor alpha into LPS sensitized mice augmented Fas and Fas ligand expression and the apoptosis of renal tubular epithelial cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The apoptosis is rapid , Fas ligand independent and completely inhibited by the calcium chelator EGTA , suggesting a fractricidal ADCC reaction and implying that NK cells are not resistant to lysis when used as target cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand was expressed in CB and in PBMC . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Treatment of experimental glioma by administration of adenoviral vectors expressing Fas ligand . ^^^ Fas ligand ( FasL ) is a cytokine , produced by activated T cells and NK cells , that triggers apoptosis of Fas positive target cells including human glioma cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis can also be induced by external signals , such as interaction of fas ligand with fas receptors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased levels of soluble Fas ligand in CSF of rapidly progressive HTLV 1 associated myelopathy / tropical spastic paraparesis patients . ^^^ The interaction of Fas ligand ( FasL ) with Fas bearing cells induces apoptosis and contributes to the negative regulation of peripheral T cell responses . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This study addresses the effects of cell density and serum on CD 95 ( APO 1 / Fas ) and CD95L ( Fas Ligand ) expression and on the induction of CD 95 dependent apoptosis in human articular chondrocytes from normal knees . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Bcl 2 mediated drug resistance : inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes ( NFAT ) induced Fas ligand transcription . ^^^ Paclitaxel and other drugs that disturb microtubule dynamics kill cells in a Fas / Fas ligand ( FasL ) dependent manner ; antibody to FasL inhibits paclitaxel induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptotic cell death mediated by an interaction of Fas with Fas ligand ( FasL ) could be a mechanism by which MHC class 2 negative pancreatic beta cells are destroyed by CD4+ T lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Both Fas receptor and Fas ligand protein levels increased after EDS , peaking at 12 18 h and declining thereafter . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Significant increases in intrapancreatic mRNA levels of TNF alpha , Fas ligand ( FasL ) , and IL 1beta converting enzyme ( ICE ) were observed from day 3 after PDL with the appearance of acinar cell apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Involvement of Fas ( CD95 / APO 1 ) and Fas ligand in apoptosis induced by ganciclovir treatment of tumor cells transduced with herpes simplex virus thymidine kinase . ^^^ Immunoblot analyses revealed that Fas ( CD95 / APO 1 ) , Fas ligand ( FasL ) and two downstream mediators , RIP and caspase 3 , ( CPP 32 , YAMA , Apopain ) were increased in GCV treated HSVtk transduced tumor cells the cell cycle arrest and before apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Human fetal retinal pigment epithelial cells induce apoptosis in allogenic T cells in a Fas ligand and PGE 2 independent pathway . ^^^ The role of Fas ligand ( FasL ) / Fas mediated T cell suppression was excluded , since FasL protein or mRNA could not be detected on HFRPE cells with flow cytometry and by reverse transcriptase polymerase chain reaction , respectively . ^^^ Additionally , the inhibitory effect of HFRPE cells could not be blocked by anti Fas ligand or antagonistic anti Fas antibodies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand : a sensor for DNA damage critical in skin cancer etiology . ^^^ Sunburn cell formation was found to be dependent on Fas ligand ( FasL ) , a pro apoptotic protein induced by DNA damage . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand requires further study ] . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas and Fas ligand in liver tissue infected with hepatitis B virus ] . ^^^ Paraffin embedded liver tissue from 60 biopsied or autopsied cases , including 20 cases each of acute mild hepatitis , chronic active hepatitis and active cirrhosis were studied with immunohistochemical double labelling technique by using polyclonal anti Fas and anti Fas ligand . ^^^ The detection rates for Fas and Fas ligand were 76 . 7 % ( 46 / 60 ) and 70 . 0 % ( 42 / 60 ) , respectively . ^^^ Fas ligand was expressed mainly in infiltrating lymphocytes in portal or periportal areas ( 34 / 42 , 80 . 9 % ) and also in the cytoplasm of some hepatocytes ( 25 / 42 , 59 . 5 % ) . ^^^ The distribution of Fas ligand positive hepatocytes was similar to that of Fas positive hepatocytes in liver tissue . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We recently showed that TRAIL mediates perforin and Fas ligand ( FasL ) independent cytotoxic activity of human CD4+ T cell clones . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas ligand induces epithelial cell apoptosis in humans with acute lung injury ( ARDS ) . ^^^ We found that soluble Fas ligand ( sFasL ) is present in bronchoalveolar lavage ( BAL ) fluid of patients before and after the onset of ARDS . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL ) is a lethal cytokine that promotes apoptosis through cross linking of the Fas receptor , although it also has other , less well understood functions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Sensitization of immunoresistant prostate carcinoma cell lines to Fas / Fas ligand mediated killing by cytotoxic lymphocytes : independence of de novo protein synthesis . ^^^ Since sensitization is achieved with chemotherapeutic drugs , and some chemotherapeutic drugs can also inhibit protein synthesis , we tested whether sensitization of prostate tumor cells to Fas ligand ( Fas L ) occurred through inhibition of protein synthesis in a manner analogous to that of TNF alpha . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand in Langerhans ' cell histiocytosis : A case report of a boy with multisystem involvement . ^^^ In addition , expressions of S 100 , CD 25 , CD 68 , CD 80 , CD 86 , and Fas ligand were identified on these cells by immunocytochemical staining . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Functional Fas ligand expression in thyrocytes from patients with Graves ' disease . ^^^ Fas / Fas ligand ( FasL ) interaction has been suggested to play a role in the pathogenesis of Hashimoto ' s thyroiditis . ^^^ Fas ligand expression in thyroid carcinomas : a potential mechanism of immune evasion . ^^^ Fas ligand ( FasL ) induces apoptosis by cross linking the Fas receptor and is expressed by cells of the immune system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Serial determination of IL 18 levels in three cases , showed a gradual decrease compared with those of IL 12 , interferon ( IFN ) gamma or soluble Fas ligand ( sFasL ) in the course of clinical improvement , and seemed to be elevated until complete disappearance of disease activity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the immune system , Fas antigen ( Fas ) and Fas ligand ( FasL ) are involved in the down regulation of immune reactions by inducing apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , the trophoblast expresses Fas ligand , thereby conferring immune privilege : maternal immune cells expressing Fas will undergo apoptosis at the placenta / decidua interface . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Naive CD4+ T cell subset is the predominant population involved in cytolysis through Fas ligand in human at birth . ^^^ Here we show that Fas ligand , a death factor that plays a key role in peripheral T cell tolerance and homeostasis , can be induced in peripheral blood mononuclear cells from both newborns ( cord ) and adults . ^^^ This lysis clearly involves a Fas based mechanism inasmuch as it was correlated with the appearance of Fas ligand transcripts and competitively inhibited by a Fas Fc fusion protein . ^^^ Finally , the model of Fas ligand exploration described herein might be of great help for the identification of Fas ligand dysregulation in various diseases in infants , including those patients with autoimmune lymphoproliferative syndrome in which Fas is functional . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TCR cross linking induces expression of the apoptosis inducing factor , Fas ligand ( FasL ) , and its expression correlates with ERK activation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased inducible apoptosis in CD4+ T lymphocytes during polymicrobial sepsis is mediated by Fas ligand and not endotoxin . ^^^ To determine if the changes in Ao are due to either endotoxin ( a product of Gram negative bacteria seen in CLP mice ) or the expression of Fas ligand ( FasL ; a mediator of activation induced lymphocyte Ao ) , a second set of studies examining Con A inducible Ao was performed with splenocytes harvested from septic endotoxin tolerant C3H / HeJ and the FasL deficient C3H / HeJ Fasl gld mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Differential activity of soluble versus cellular Fas ligand : regulation by an accessory molecule . ^^^ Fas ligand induces apoptosis by binding to its receptor Fas . ^^^ Fas ligand is a type 2 membrane protein that is cleaved by a metalloproteinase to produce an active , soluble molecule . ^^^ It has been found that a variety of target cells are differentially sensitive to soluble and membrane associated forms of Fas ligand . ^^^ One proposed explanation for this differential activity is that membrane associated Fas ligand is more efficiently aggregated than soluble Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Adenoviruses encode proteins that block responses to interferons , intrinsic cellular apoptosis , killing by CD 8 ( + ) cytotoxic T lymphocytes and killing by the death ligands TNF , Fas ligand and TRAIL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Early detection of apoptosis and fas ligand expression in hepatic graft versus host disease after rat small bowel transplantation . ^^^ The purpose of this study is to investigate the involvement of the Fas / Fas ligand system in hepatic GVHD after rat semiallogeneic intestinal transplantation . ^^^ In an immunohistochemical study , Fas was constitutively expressed in the liver in both groups , while Fas ligand was expressed most extensively on Day 13 in group 1 . ^^^ Immunoreactivity of both Fas and Fas ligand was observed in hepatocytes , in addition to leukocytes . ^^^ Analysis by reverse transcription polymerase chain reaction also revealed the expression of Fas mRNA to be constitutive in both groups , while that of Fas ligand mRNA increased significantly from Day 5 and peaked on Day 13 in group 1 , and the expression was 10 times stronger than that for isogeneic combination ( group 2 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Shc SH 2 ( the SH 2 domain of Shc ) or Shc Y239 / 240F ( full length Shc in which tyrosines 239 and 240 have been mutated to phenylalanine ) resulted in the inhibition of activation induced cell death and Fas ligand up regulation after TCR cross linking . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The death receptor Fas transduces apoptotic death signaling upon stimulation with the Fas ligand . ^^^ In the present study , we investigated whether the Fas ligand also plays a dominant role in vaginal cell death using the functional Fas ligand lacking gld mutant mouse . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Role of IFN gamma produced after intraperitoneal transplantation of AK 5 cells in the induction of Fas ligand expression by tumor cells leading to immune evasion . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : TNF alpha , Fas ligand ( FasL ) , and TRAIL ( tumor necrosis factor related apoptosis inducing ligand ) messenger RNA ( mRNA ) expression were examined in liver , lung , spleen , and kidney after either a cecal ligation and puncture or endotoxemic shock with use of semiquantitative reverse transcriptase polymerase chain reaction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cell death induced by the Fas / Fas ligand pathway and its role in pathology . ^^^ Engagement of the cell death surface receptor Fas by Fas ligand ( FasL ) results in apoptotic cell death , mediated by caspase activation . ^^^ Fas ligand is induced in activated T cells , resulting in activation induced cell death by the Fas / FasL pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
FAS FAS ligand interaction has been implicated in increased enterocyte apoptosis seen in immune mediated bowel injury . ^^^ In the present study , the regulation of enterocyte FAS and FAS ligand expression by cytokines and its functional role in human intestinal epithelial cell apoptosis and proliferation were analyzed with two different models : a nontransformed human intestinal epithelial cell line ( HIEC ) and normal colonic explant cultures . ^^^ Neither FAS ligand expression nor its induction by cytokines was observed in HIEC or colonic explants . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The 22 rats with chronic graft rejection showed increased CD8a like antigen ( probably Fas ligand ) on the peripheral blood T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We previously demonstrated the excessive apoptosis of lung epithelial cells and the upregulation of Fas and Fas ligand ( FasL ) in fibrosing lung diseases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We introduced the Bcl 2 gene to gliomas via adenovirus ( Adv ; Adv Bcl 2 ) with the Adv for Fas ( Adv Fas ) and the Adv for Fas ligand ( Adv FL ) to evaluate the antiapoptotic function of Bcl 2 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression . p 38 mitogen activated protein kinase ( MAPK ) is activated by T cell receptor engagement . ^^^ Instead , SB 203580 preferentially inhibited activation induced Fas ligand ( FasL ) expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Differential increase of Fas ligand expression on metastatic and thin or thick primary melanoma cells compared with interleukin 10 . ^^^ Fas ligand ( FasL ) , a cell surface molecule belonging to the tumour necrosis factor family , binds to its receptor Fas and thus induces apoptosis of Fas bearing cells such as activated lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunohistochemistry using monoclonal antibodies directed against HLA molecules , HMB 45 , P 53 , Fas ligand ( FasL ) , Fas , Bcl 2 and tumour infiltrating cells was applied to sections of an enucleated eye containing a uveal melanoma that received TTT 1 week before enucleation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Resistance to Fas ( APO 1 / CD95 ) mediated apoptosis and expression of Fas ligand in esophageal cancer : the Fas counterattack . ^^^ Recently , two independent reports have shown that esophageal tumor cells abundantly express Fas ligand ( FasL ) in vivo . ^^^ Fas ligand expressed by esophageal cell lines has been shown to induce apoptosis of cocultured Fas sensitive lymphoid cells in vitro . ^^^ By expressing functional Fas ligand , esophageal cancer cells can deplete antitumor lymphocytes by inducing apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand and Fas receptor are coexpressed in normal human esophageal epithelium : a potential mechanism of apoptotic epithelial turnover . ^^^ Fas ( CD95 / Apo 1 ) receptor ( FasR ) is a cell surface receptor that mediates apoptotic cell death upon triggering by Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Fas ligand mediated elimination of antigen bearing Langerhans cells in draining lymph nodes . ^^^ Clearance of the antigen bearing LC was significantly delayed and the ratio of dead cells was reduced in Fas deficient lpr and Fas ligand ( FasL ) deficient gld mice at 2 days after skin painting , suggesting the involvement of a Fas / FasL mediated pathway in the elimination of antigen bearing LC in draining lymph nodes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand induced apoptosis of hepatocytes in natural killer cell leukaemia . ^^^ Neoplastic natural killer ( NK ) cells overexpress Fas ligand ( FasL ) , which may cause damage of Fas bearing tissues . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Inverse correlation between apoptotic ( Fas ligand , caspase 3 ) and angiogenic factors ( VEGF , microvessel density ) in squamous cell lung carcinomas . ^^^ In order to explore whether apoptosis is associated with angiogenesis in lung cancer , immunohistochemistry was employed to determine the pro apoptotic factors Fas ligand ( FasL ) and caspase 3 ( Cas 3 ) in 70 squamous cell lung carcinomas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : Fas ligand ( FasL , CD95L ) predominantly expressed on activated cytotoxic T cells and NK cells triggers apoptosis in Fas receptor ( Apo 1 , CD 95 ) positive target cells . ^^^ Induction of Fas ligand ( CD95L ) by the toxic mistletoe lectins in human lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Characterization of a novel cis element that regulates Fas ligand expression in corneal endothelial cells . ^^^ Constitutively expressed Fas ligand in the cornea , Sertoli cell of the testes , Paneth cell of the intestines , and Clara cell of the airway protect surrounding parenchymal tissue by inducing apoptosis of Fas ( + ) immune cells during inflammatory reactions . ^^^ Indeed , the action of corneal Fas ligand has been suggested to facilitate successful allogeneic cornea transplantation . ^^^ To study the transcriptional regulation of Fas ligand in the eye , we employed an immortalized mouse corneal endothelial cell line ( C3H3 ) that constitutively expresses Fas ligand . ^^^ By deletion analysis of the mouse Fas ligand promoter , gel mobility shift assays , and site directed mutagenesis , we found that a TCCT motif located 299 base pairs upstream from the transcriptional start site served as a major positive regulatory cis element in C3H3 cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : Apoptosis and the expression of its related proteins , Fas , Fas ligand ( FasL ) , bcl 2 and p 53 , in epithelial cells of human ovarian tumors of different histological grades , were determined immunohistochemically and morphometrically . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Transplacental effects of IgG generated against soluble 53 kDa protein on the splenic lymph system of rat progeny exposed to carcinogen : rate of apoptosis , proliferation of lymphocytes and expression of Fas and Fas ligand proteins . ^^^ After 4 months , their spleens were resected and evaluated immunohistochemically for lymphocyte proliferation , apoptosis and apoptosis related proteins ( Fas and Fas ligand ) , in tumor free and tumor bearing animals . ^^^ Maternal vaccination also resulted in a significant rise of Fas ligand positive lymphocytes in the follicles and PALS of their tumor free offspring . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas Fas ligand mediated apoptosis within aqueous during idiopathic acute anterior uveitis . ^^^ Experimentally , Fas Ligand ( FasL ) mediated apoptosis of Fas+ inflammatory cells contributes to the immune privilege within the anterior chamber and provides an explanation for the success of corneal allograft transplantation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
IL 2 up regulated Fas ligand ( FasL ) and down regulated gamma c expression on activated 2C cells in vitro and in vivo . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Differential control of autoantibodies and lymphoproliferation by Fas ligand expression on CD4+ and CD8+ T cells in vivo . ^^^ Furthermore , in vivo depletion of normal Thy 1+ cells restores lymphoproliferation and autoantibody production in such chimeras , suggesting that T cells bearing Fas ligand are responsible for correcting the gld defect . ^^^ These results suggest that both T cell subsets provide Fas ligand to suppress immune cells responsible for autoantibody production ; however , CD8+ T cells are mainly responsible for preventing lymphoproliferation . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Few patients had detectable serum levels of soluble fas ligand but approximately half had elevated levels of a tumor marker , detected with the CA 15 . 3 assay , known as soluble MUCIN 1 ( MUC 1 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( CD 95 , APO 1 ) is a member of the TNF receptor family , and engagement of Fas by its ligand , Fas ligand ( FasL ) , can induce apoptotic death of Fas expressing cells . ^^^ Fas ligand promotes cell survival of immature human bone marrow CD34+CD38 hematopoietic progenitor cells by suppressing apoptosis . ^^^ Fas ( CD 95 , APO 1 ) is a member of the TNF receptor family , and engagement of Fas by its ligand , Fas ligand ( FasL ) , can induce apoptotic death of Fas expressing cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Six clones overexpressed Fas ligand ( Fas L ) mRNA and Fas antigen was detected on all clones at the mRNA level . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Calorie restriction increases Fas / Fas ligand expression and apoptosis in murine splenic lymphocytes . ^^^ Similarly , Fas ligand ( Fas L ) expression was higher in anti CD 3 stimulated CD4+ and CD8+ T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Molecular mechanisms and biological roles of apoptosis and inflammation induced by Fas ligand ] . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These biological characteristics include induction of peripheral blood mononuclear cell ( PBMC ) proliferation , upregulation of activation markers and Fas ligand expression , and increased levels of apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / APO 1 ( CD 95 ) receptor and Fas ligand have been implicated as key factors in apoptosis . ^^^ Fas / APO 1 ( CD 95 ) receptor and Fas ligand have been implicated as key factors in apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : Three color flow cytometry was used to clarify apoptosis of lymphocytes in the peripheral blood and colonic mucosa of patients with active and inactive UC compared with controls using fluorescence labeled monoclonal and polyclonal antibodies such as Fas ( CD 95 ) , Fas ligand , CD 4 , CD 8 , CD45RO , etc . ^^^ There was unbalanced immunoregulation between CD 4 and CD 8 T cells in the colonic mucosa of UC probably due to apoptosis through Fas Fas ligand system . ^^^ CONCLUSIONS : Abnormal GALT system was found in UC probably due to dysregulation of T cells through Fas Fas ligand system . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cryptosporidium parvum induces apoptosis in biliary epithelia by a Fas / Fas ligand dependent mechanism . ^^^ Both caspase protease inhibitors and neutralizing antibodies to either Fas receptor ( Fas ) and Fas ligand ( FasL ) inhibited this process ; neutralizing antibodies to other apoptotic cytokines [ interleukin 1beta ( IL 1beta ) , tumor necrosis factor alpha ( TNF alpha ) , and transforming growth factor beta ( TGF beta ) ] had no effect . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( CD95L ) and tumor necrosis factor alpha ( TNF alpha ) are pivotal inducers of hepatocyte apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We show that macrophages are sensitive to sTat stimulation at concentrations 1 , 000 fold lower ( 500 pM ) than T cells , and this stimulation is accompanied by the immunosuppressive induction of Fas ligand on the macrophage . ^^^ T cell proliferative defects induced by sTat in vitro can be completely ( at lower concentrations of sTat ) or partially ( at higher concentrations ) reversed by antagonists to Fas / Fas ligand interaction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Levels of other inflammatory mediators ( IL 1 beta , tumor necrosis factor alpha , granulocyte macrophage colony stimulating factor , soluble Fas , soluble Fas ligand ) were unaltered . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The transactivation of hepatitis B virus 10 protein on the expression of Fas ligand in HepG 2 cells ] . ^^^ OBJECTIVE : To study the effect of hepatitis B virus 10 ( HBx ) protein on the expression of Fas Ligand in HepG 2 cells . ^^^ The expressions of HBx gene and Fas Ligand gene were detected by RT PCR . ^^^ RESULTS : It showed that Fas Ligand gene expressed in the modified HepG 2 cells transfected with plasmid pCEP4x . ^^^ CONCLUSIONS : The results suggest the expression of Fas Ligand in HepG 2 cells could be activated by HBx protein . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cyclosporine downregulates Fas ligand expression on vascular endothelial cells : implication for accelerated vasculopathy by immunosuppressive therapy . ^^^ We reported that vascular endothelial cells naturally express a death factor , Fas ligand , that may function to inhibit detrimental leukocyte infiltration . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased serum soluble Fas ligand associated with recurrent B cell non Hodgkin ' s lymphoma after autologous peripheral blood stem cell transplantation . ^^^ Fas ligand ( FasL ) is a member of the tumor necrosis factor family and transmits apoptotic cell death signal by binding to its receptor , Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To establish a new clinical index for immunological abnormalities occurring in silicosis , several clinical parameters related to Fas mediated apoptosis ; i . e . , membrane Fas expression on peripheral blood lymphocytes ( mFas ) , serum soluble Fas levels ( sFas ) , serum soluble Fas ligand levels ( sFasL ) , and soluble / membrane Fas mRNA expression ratios ( s / mFas ExR ) in peripheral blood mononuclear cells ( PBMC ) were investigated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Hypothesis : A recurrent , moderate activation fosters systemic autoimmunity the apoptotic roles of TCR , IL 2 and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Prognostic significance of Fas and Fas ligand expressions in human esophageal cancer . ^^^ Esophageal carcinomas have recently been shown to express Fas ligand ( FasL ) and down regulate Fas to escape from host immune surveillance . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It has been suggested that one means by which chemotherapeutic agents exert their effect on leukaemic cells , is via autocrine induction of fas ligand which then binds to fas ( CD 95 ) , activates the caspase pathway and results ultimately in apoptotic death . ^^^ Inhibition of FAS / FAS ligand does not block chemotherapy induced apoptosis in drug sensitive and resistant cells . ^^^ In order to test this hypothesis , we have treated leukaemic cell lines with various chemotherapeutic agents ( idarubicin , etoposide , fludarabine and 2 CdA ) with and without pre treatment with fas ( ZB 4 ) and fas ligand ( NOK 1 ) blocking monoclonal antibodies . ^^^ In addition , CEM / VLB100 were slightly more sensitive to treatment with CH 11 ( 100 ng / ml ) than parental CEM cells ( % age apoptosis = 30 . 35 and 23 . 675 , p = 0 . 024 ) and at least as sensitive to recombinant fas ligand ( 50 ng / ml ) ( % age apoptosis = 26 . 6 and 20 . 2 , p = NS ) . ^^^ We conclude that it is unlikely that fas / fas ligand interactions play a significant role in the induction of apoptosis by these chemotherapeutic agents in the leukaemic cell lines tested . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Upregulated expression of Fas and Fas ligand in brain through the spectrum of HIV 1 infection . ^^^ Since apoptotic events may be induced by the Fas Fas ligand ( FasL ) system , we analyzed the relevance of these molecules to cell depletion in eight brains from HIV 1 infected patients and nine HIV 1 negative controls all of whom were analyzed histopathologically . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Co expression of Fas and Fas ligand in human non astrocytic glial tumors . ^^^ The study of Fas ( APO 1 / CD95 ) and Fas ligand ( FasL ) expression in human glial neoplasms has been primarily restricted to astrocytomas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We evaluated the presence of soluble Fas ( sFas ) , Fas ligand ( sFasL ) , and Bcl 2 in the sera of patients with multiple sclerosis ( MS ) or human T lymphotropic virus type 1 ( HTLV 1 ) associated myelopathy ( HAM ) using an enzyme linked immunosorbent assay ( ELISA ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
T ( h ) 1 and T ( h ) 2 related cytokines ( IFN gamma , IL 2 , IL 4 , IL 10 ) , beta chemokines ( RANTES , macrophage inflammatory protein 1beta ) and their receptor [ chemotatic cytokine receptor ( CCR ) 5 ] , and the cytolytic effector molecule [ Fas ligand ( FasL ) ] play an essential role in regulating and co ordinating acute renal allograft rejection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NF kappa B dependent Fas ligand expression . ^^^ Apoptosis of lymphocytes is triggered by different stimuli through the induced expression of Fas and Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Decreased expression of the Fas ligand on peripheral blood mononuclear cells and undetectable levels of soluble Fas ligand in the serum of patients with aplastic anemia and myelodysplastic syndrome . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tumor regression after adoptive transfer of effector T cells is independent of perforin or Fas ligand ( APO 1L / CD95L ) . ^^^ Perforin and Fas ligand ( APO 1 / CD95 ligand ) mediated cytotoxicity have been proposed as mechanisms for T cell mediated tumor destruction . ^^^ To determine the role of perforin and Fas ligand ( FasL ) in T cell mediated tumor regression in a murine melanoma model , B16BL6 D 5 ( D 5 ) , we generated D 5 specific effector T cells from tumor vaccine draining lymph nodes of wild type ( wt ) , perforin knock out ( PKO ) , or FasL mutant ( gld ) mice and treated established D 5 metastases in mice with the same genotype . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : Fas ligand ( FasL ) is a transmembrane protein that induces apoptosis ( programmed cell death ) in susceptible cells by interacting with its receptor , Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activation of Stat 5 by IL 2 was found to be involved in T cell proliferation and promoted Fas ligand ( FasL ) expression and AICD . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Caspase 1 independent , Fas / Fas ligand mediated IL 18 secretion from macrophages causes acute liver injury in mice . ^^^ Here , we investigated caspase 1 independent processing of IL 18 in Fas ligand ( FasL ) stimulated macrophages and its involvement in liver injury . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Abnormal , constitutive expression of Fas ligand may be more relevant to the aetiology of these diseases . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
When the membrane receptor Fas binds its ligand , Fas ligand ( FasL ) , an apoptotic cascade is initiated in the cell bearing the Fas receptor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand is highly expressed in acute leukemia and during the transformation of chronic myeloid leukemia to blast crisis . ^^^ Fas ligand ( FasL ) induces apoptosis in susceptible Fas bearing cells and is critically involved in regulating T cell immune responses . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Lastly , 1 , 25 ( OH ) ( 2 ) D ( 3 ) treatment of ALVA 31 and PPC 1 spheroids greatly reduced intercellular adhesions , and rendered ALVA 31 spheroids resistant to apoptotic induction by Fas ligand expressed via a recombinant adenoviral construct . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cell mediated cytotoxicity induced by CTLs and NK cells is mainly regulated by the perforin granzyme , the Fas ligand ( Fas L ) , and the Tumor Necrosis Factor ( TNF ) alpha pathways . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Additionally , an immunoperoxidase method was used to detect EBV latent membrane protein 1 ( LMP 1 ) , p 53 , CD45RO ( UCHL 1 ) , Fas ligand ( Fas L ) , and RNA ISH with oligonucleotide sequences was used to detected interleukin 6 ( IL 6 ) mRNA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interferon alpha augments activation induced T cell death by upregulation of Fas ( CD95 / APO 1 ) and Fas ligand expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
IL 18 induces gene expression and synthesis of tumor necrosis factor ( TNF ) , IL 1 , Fas ligand , and several chemokines . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition to this passive evasion of immune regulation , MM tumour cells are capable of producing a number of immunologically active agents which can induce immunosuppression such as transforming growth factor beta , Fas ligand ( FasL ) , vascular endothelial growth factor and Muc 1 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Role of Fas Fas ligand interactions in 2 , 3 , 7 , 8 tetrachlorodibenzo p dioxin ( TCDD ) induced immunotoxicity : increased resistance of thymocytes from Fas deficient ( lpr ) and Fas ligand defective ( gld ) mice to TCDD induced toxicity . 2 , 3 , 7 , 8 Tetrachlorodibenzo p dioxin ( TCDD ) is a highly toxic environmental pollutant well known for its toxicity to the thymus . ^^^ In contrast , a similar treatment with TCDD , in Fas deficient C57BL / 6 lpr / lpr ( lpr ) or Fas ligand defective C57BL / 6 gld / gld ( gld ) , mice failed to induce thymic atrophy at 0 . 1 5 microg / kg body wt of TCDD . ^^^ The sera from TCDD treated wild type mice exhibited increased levels of soluble Fas ligand , inasmuch as incubation of Fas ( + ) , but not Fas ( ) cells with the sera , triggered apoptosis . ^^^ Together , the current study demonstrates that Fas Fas ligand interactions play an important role in TCDD mediated induction of apoptosis and immunotoxicity . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The purpose of this study is to investigate the involvement of Fas / Fas ligand system in pulmonary injury after rat semi allogeneic intestinal transplantation . ^^^ In an immunohistochemical study , Fas was constitutively expressed in the lung , although Fas ligand was expressed most extensively on day 9 . ^^^ The immunoreactivity of both Fas and Fas ligand were observed in alveolar cells , in addition to leukocytes . ^^^ An analysis by reverse transcription polymerase chain reaction also revealed that the expression of Fas mRNA was constitutive without any significant change , although that of Fas ligand mRNA increased substantially and peaked on day 9 , which was significant compared to the isogeneic combination . ^^^ In conclusion , transcriptionally up regulated Fas ligand and increased number of apoptosis suggests that the Fas system may play a role in the pathophysiology of GVHD induced pulmonary injury . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Structure activity relationship of hydroxamate based inhibitors on membrane bound Fas ligand and TNF alpha processing . ^^^ Both Fas ligand ( FasL ) and tumor necrosis factor alpha ( TNF alpha ) are type 2 integral membrane proteins . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , only one clone expressed Fas ligand ( Fas L ) mRNA , and neither perforin nor granzyme A / B was expressed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand is expressed on human squamous cell carcinomas of the head and neck , and it promotes apoptosis of T lymphocytes . ^^^ Recent reports have variously described expression of Fas ligand ( FasL ) or its absence in human tumors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Perforin and Fas / Fas ligand mediated cytotoxicity in acute and chronic woodchuck viral hepatitis . ^^^ The Fas ligand ( FasL ) / Fas and the perforin granzyme cytotoxic pathways presumably play a central role in the development of hepatocellular injury in viral hepatitis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cell mediated cytotoxicity is exerted via perforin and Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To determine the mechanisms responsible for the impaired lymphocyte mediated cytotoxicity in Chediak Higashi syndrome ( CHS ) , we investigated the killing ability of peripheral blood lymphocytes ( PBL ) from three patients with CHS using several kinds of target cells that were sensitive to perforin , Fas ligand ( FasL ) , and / or tumour necrosis factor alpha ( TNF alpha ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The fas and fas ligand pathways in liver allograft tolerance . ^^^ The Fas and Fas ligand ( Fas / FasL ) pathways may play a central role in cytotoxicity or immunoregulation in liver transplantation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Mice deficient for both the CTL effector molecule perforin and the apoptosis inducing Fas ligand spontaneously develop infiltration of highly activated CD 8 ( + ) T cells in kidney and liver and die between 5 and 12 weeks of age . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Both Fas antigen and Fas ligand immunoreactivity were detected in the infiltrating mononuclear cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tumor necrosis factor alpha and interferon gamma induce expression of functional Fas ligand on HT 29 and MCF 7 adenocarcinoma cells . ^^^ Tumor cells develop diverse mechanisms to escape from immune surveillance , including expression of Fas ligand ( FasL ) , a 40 kDa type 2 transmembrane protein that mediates apoptosis by binding to its cognate receptor Fas ( APO 1 / CD95 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas signaling system is composed of the interacting proteins Fas ( CD95 / APO 1 ) and Fas ligand ( FasL , CD95L , APO 1L ) and is proposed to act in the testis as a paracrine signaling mechanism by which FasL expressing Sertoli cells initiate apoptosis of Fas bearing germ cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Human DU 145 prostate cancer cells overexpressing mitogen activated protein kinase phosphatase 1 are resistant to Fas ligand induced mitochondrial perturbations and cellular apoptosis . ^^^ MKP 1 overexpression in DU 145 cells was also found to inhibit Fas ligand ( FasL ) induced apoptosis , as well as block the activation of caspases by Fas engagement . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The most interesting publication over the review period with regard to the core immune effects of blood transfusion relates to measured concentrations of active , soluble molecules like HLA class 1 and 2 and Fas ligand molecules and to their in vitro immunomodulating effect as well as effects on induction of apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand is frequently expressed in human pancreatic duct cell carcinoma . ^^^ Fas ligand ( Fas L ) is a key molecule in normal immune development , homeostasis , modulation , and function . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression in the germinal centre . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The mechanisms of apoptosis in neuroblastomas have been investigated by examining the expression profiles of Fas , Fas ligand ( FasL ) , and caspase 3 in 42 primary tumour tissues . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The mutation of the Fas or Fas ligand ( FasL ) has been observed in a minority of patients with autoimmune disease . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand expression in inflamed islets in pancreas sections of patients with recent onset Type 1 diabetes mellitus . ^^^ Our previous study indicated that the Fas Fas ligand ( FasL ) pathway is required for the development of autoimmune diabetes in the NOD mouse . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Epstein Barr virus induces Fas ( CD 95 ) in T cells and Fas ligand in B cells leading to T cell apoptosis . ^^^ Our in vitro results indicate that EBV increased Fas expression in CD 4 ( + ) T cells and Fas ligand ( FasL ) expression in B cells and macrophages . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cloning and expression of a short Fas ligand : A new alternatively spliced product of the mouse Fas ligand gene . ^^^ Fas ligand ( FasL ) , a 40 kD type 2 membrane protein also expressed in activated T cells , belongs to the tumor necrosis factor ligand family . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Whereas mature bone marrow or spleen derived DCs expressed high levels of Fas , these DCs were relatively insensitive to Fas mediated killing by the agonist mAb , Jo 2 , as well as authentic Fas ligand expressed on the CD4+ T cell line , A . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the present study , freshly isolated , nonactivated , human NK cells were shown to express TNF , lymphotoxin ( LT ) alpha , LT beta , Fas ligand ( L ) , CD27L , CD30L , OX40L , 4 1BBL , and TNF related apoptosis inducing ligand ( TRAIL ) , but not CD40L or nerve growth factor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The present study investigated the gene expression of interleukin ( IL ) 1beta , IL 2 , IL 4 , IL 6 , IL 10 , tumor necrosis factor ( TNF ) alpha , interferon ( IFN ) gamma , and Fas ligand in chronically rejecting DBA / 2 to B 10 . ^^^ Fas ligand , and the Th 1 cytokines IL 2 and IFN gamma , were vigorously induced in allografts at day 7 , when histology showed pronounced parenchymal rejection , and rapidly decreased by day 28 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Effect of graft versus host disease ( GVHD ) on host hematopoietic progenitor cells is mediated by Fas Fas ligand interactions but this does not explain the effect of GVHD on donor cells . ^^^ Furthermore , the injection of Fas ligand ( FasL ) deficient B6 / gld spleen cells failed to affect host bone marrow cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( fasL ) was not detectable on antigen specific CD 8 clones , T cell lines , or circulating HIV specific CD 8 T cells from HIV infected donors , stained with a tetrameric HLA A 2 HIV peptide complex . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recently activated peripheral T cells treated with IL 2 for 4 days expressed Fas ligand ( FasL ) mediated cytotoxicity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Synergistic action of protein kinase C theta and calcineurin is sufficient for Fas ligand expression and induction of a crmA sensitive apoptosis pathway in Jurkat T cells . ^^^ Deletion of activated peripheral T cell clones by apoptosis requires the regulated expression of Fas ligand ( FasL ) and sensitization of these cells to CD 95 mediated signaling . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The role of mTNF alpha in the cytotoxic activity of resting NK cells has been evaluated in in vitro cytotoxic assays using freshly purified NK cells fixed with paraformaldehyde as effector cells ( in order to avoid the participation of cytotoxic soluble mediators such as perforin , granzymes or sTNF alpha ) and the TNF alpha sensitive Fas ligand and TRAIL resistant cell line KYM 1 D 4 as target cell . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TRAIL , the ligand for the newly discovered DR 4 and DR 5 receptor , is a member of the TNF family of death signal transduction proteins with a mechanism of cell death similar to that of Fas and Fas ligand ( Fas L ) system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand ( Fas L ) molecules are thought to play an important role in the deletion of autoimmune reactive T cells through apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It has been suggested that Fas ligand ( FasL ) , expressed by several neoplastic cell lines and some tumors in vivo , is able to trigger the apoptotic process in activated T lymphocytes and may constitute a key element of the immunological escape mechanisms used by many types of neoplasia . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Blocking antibody to CD 40 and CD 154 ( CD 40 ligand ) decreased the ability of monocytes to aid in T cell survival , whereas , blocking LFA 1 / I CAM 1 , Fas ligand and the CD4 / major histocompatibility complex class 2 interaction did not affect the influence of monocytes on T cell survival . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased expression of Fas ligand on Mycobacterium tuberculosis infected macrophages : a potential novel mechanism of immune evasion by Mycobacterium tuberculosis . ^^^ Parallel sections were analyzed for detection of mycobacterial antigens , Fas , and Fas ligand ( FasL ) by immunohistochemistry , and for apoptotic cells by terminal deoxynucleotidyl transferase mediated dUTP digoxigenin nick end labeling ( TUNEL ) method . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand expression in cystic fibrosis airway epithelium . ^^^ A study was undertaken to investigate the expression of Fas and Fas ligand ( FasL ) in CF bronchial epithelium and CF tracheal cell lines . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Influence of cytokines on the expression of fas ligand and CD 44 splice variants in colon carcinoma cells . ^^^ The expression of Fas ligand ( FasL ) by malignant cells might be a mechanism for tumor immune escape . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / APO 1 ( or CD 95 ) is a 45 kDa cell surface glycoprotein that transduces cellular death signals for apoptosis upon cross linking with the Fas ligand , which is experimentally replaced by anti Fas antibodies . ^^^ Fas / APO 1 ( or CD 95 ) is a 45 kDa cell surface glycoprotein that transduces cellular death signals for apoptosis upon cross linking with the Fas ligand , which is experimentally replaced by anti Fas antibodies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Protein kinase ctheta cooperates with calcineurin to induce Fas ligand expression during activation induced T cell death . ^^^ Activation induced cell death is mediated by the TCR induced expression of the Fas ligand ( FasL ) on the surface of T cells , followed by binding to its receptor Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Overexpression of Fas ligand ( FasL ) during malignant transformation in the large bowel and in Barrett ' s metaplasia of the esophagus . ^^^ Esophageal and colorectal adenocarcinomas overexpress Fas ligand ( FasL ) , which can protect them from immune surveillance . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
THP 1 monocytic leukemia cells express Fas ligand constitutively and kill Fas positive Jurkat cells . ^^^ Normal human monocytes express Fas and are susceptible to Fas ligand ( FasL ) induced apoptosis . ^^^ Because the myeloid leukemia cell lines HL 60 and THP 1 can be differentiated into functional monocytes and macrophages , we studied their expression of Fas and Fas ligand ( FasL ) to determine whether there were differentiation associated changes in these proteins . ^^^ THP 1 , HL 60 and HCW 2 , both before and after treatment with PMA , expressed high levels of Fas ligand ( FasL ) , but did not express Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cholangiocarcinomas express Fas ligand and disable the Fas receptor . ^^^ Current concepts support escape from immune surveillance using aberrant expression of Fas ligand ( FasL ) and dysregulation of receptor ( FasR ) signaling as a potential mechanism for tumor progression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Flow cytometry was also performed for detection of Fas or Fas ligand expression on AY 27 cells . ^^^ Neither Fas nor Fas ligand was expressed on AY 27 cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , decreased Bcl 2 and increased Fas ligand ( Fas L ) also were observed in the n 3 PUFA fed group compared to the n 6 PUFA fed group . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas and Fas ligand in human tear fluid after photorefractive keratectomy . ^^^ BACKGROUND / AIMS : The Fas Fas ligand system is thought to be involved in stromal cell apoptosis after corneal wounding . ^^^ The aim was to measure changes in human tear fluid levels of soluble Fas ( sFas ) and Fas ligand ( sFasL ) following myopic photorefractive keratectomy ( PRK ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Defective lymphocyte apoptosis caused by mutations of the Fas ( CD 95 ) gene has been linked in the pathogenesis of ALPS , as binding of Fas ligand to Fas can trigger apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand gene expression in autoimmune thyroiditis in BB / W rats . ^^^ Recent studies reported contradictory results regarding the regulation of Fas / Fas ligand ( FasL ) expression by cytokines in vitro . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Blockade of B 7 2 / CD 28 interactions with anti B 7 2 mAb strongly inhibited granzyme B , but not perforin or Fas ligand gene expression , suggesting an explanation for the inhibitory effect of anti B 7 2 mAb on AK T cell development . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Controlled Fas ligand gene expression by Cre / loxP mediated switching system : high levels of FasL expression result in lethal hepatitis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
AFP notably decreased basal levels of soluble and membrane bound Fas ligand . ^^^ Taken as a whole , our data demonstrate that : ( a ) AFP induces apoptosis in tumor cells independently of Fas / Fas ligand or TNFR / TNF signaling pathways , and ( b ) AFP mediated cell death involves activation of the effector caspase 3 like proteases , but is independent of upstream activation of the initiator caspase 1 , caspase 8 , and caspase 9 like proteases . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression was virtually undetectable in MNC cultured for 5 7 days with or without cytokines . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Addition of an antagonistic Fas ligand antibody to Flip antisense treated macrophages rescued cultures from apoptosis , demonstrating that endogenous Flip blocked Fas induced cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fractions enriched for the G 0 G1 , S , and G 2 M phases of the cell cycle were assayed for T cell receptor mediated activation as measured by intracellular Ca ( 2+ ) flux , cytolytic recognition of tumor targets , and induction of Fas ligand mRNA . ^^^ Susceptibility to apoptosis induced by recombinant Fas ligand and activation induced cell death were also studied . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble fas ligand in natural killer cell lymphoma . ^^^ We measured serum soluble Fas ligand ( sFasL ) in a patient with natural killer cell lymphoma , and investigated relationship between sFasL and liver dysfunction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ceramide is characterized as a second messenger of apoptosis induced by various agents such as tumor necrosis factor ( TNF alpha ) , Fas ligand , hydrogen peroxide , heat shock and ionizing radiation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased serum soluble Fas ligand in hyperthyroid Graves ' disease ] . ^^^ Recent studies suggest that Fas and Fas ligand ( FasL ) interactions among thyrocytes from patients with Hashimoto disease which is caused by thyroid autoimmunity may contribute to clinical hypothyroidism . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The immunohistochemistry and in situ hybridization for Fas ligand ( FasL ) expression showed that the expression of Fas ligand was increased in the EAAU eyes compared with control eyes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Serum levels of soluble Fas ligand in patients with silicosis . ^^^ Fas ligand ( FasL ) is a type 2 membrane protein which induces apoptosis by binding to its membrane receptor , Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunohistochemical analysis of Fas ligand expression in normal human tissues . ^^^ Cross linking of Fas and Fas ligand ( FasL ) induces apoptosis in Fas bearing cells and regulates apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The neoplastic cells of all cases contained activated cytotoxic molecules of TIA 1 , granzyme B , Fas ligand , and / or perforin . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Granzyme B , perforin and Fas ligand ( FasL ) are also expressed in activated CTLs and NK cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( CD 95 ) is a cell surface glycoprotein that mediates apoptotic cell death when cross linked with agonistic anti Fas monoclonal antibodies ( MAbs ) or the endogenous Fas ligand . ^^^ Fas ( CD 95 ) is a cell surface glycoprotein that mediates apoptotic cell death when cross linked with agonistic anti Fas monoclonal antibodies ( MAbs ) or the endogenous Fas ligand . ^^^ K14 ) efficiently blocked apoptotic cell death induced by the CH 11 MAb or Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis was induced in the AEC derived human lung carcinoma cell line A 549 or in primary AECs isolated from adult rats with receptor activating anti Fas antibodies or purified recombinant Fas ligand , respectively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The protection appears to result from its capacity to block Fas mediated death signals rather than from inhibition of the upregulation of Fas and / or Fas ligand after T cell stimulation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Peritumoural cytotoxic lymphocytic infiltrates in colorectal carcinoma may attack tumour cells by expressing Fas ligand and inducing tumour cell apoptosis . ^^^ However , tumours may mount a by down regulating their Fas pathway and expressing Fas ligand themselves to induce apoptosis of lymphocytes . ^^^ This study used immunohistochemistry to demonstrate the presence of CD8+ lymphocytes and Fas ligand . ^^^ The score of CD8+ peritumoural lymphocytes was negatively correlated with the Fas ligand score of the tumour . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand improves the effect of IL 4 in collagen induced arthritis . ^^^ The present study was aimed at investigating whether the expression of Fas ligand ( FasL ) by CHO cells transfected with IL 4 ( CHO / IL 4 ) or IL 10 ( CHO / IL 10 ) genes would improve the effect of the cytokine . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Second , the reduced expression of major histocompatibility complex ( MHC ) determinants is less effective in inducing the alloantigen primed T cell response , which in turn induces the downregulation of Th 1 cytokines , beta chemokines , and Fas ligand , but spares protective Th 2 cytokines , and leads to minimal induction of MHC and adhesion molecules on immature renal parenchymal elements . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Brucella infection also rendered macrophage like cells resistant to Fas ligand or gamma interferon induced apoptosis , suggesting that Brucella infection protected host cells from several cytotoxic processes occurring at different steps of the immune response . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND / AIMS : Tumor necrosis factor a ( TNF alpha ) and Fas ligand are apoptotic cell death mediators that act by binding to their responsive receptors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Dendritic cells genetically engineered to express Fas ligand induce donor specific hyporesponsiveness and prolong allograft survival . ^^^ In this study , the immunomodulatory effects of transfecting murine bone marrow derived DC with Fas ligand ( FasL ) were investigated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In these forms of viral hepatitis , liver infiltrating lymphocytes that recognize the viral antigen on hepatocytes become activated and express cytolytic Fas ligand ( FasL ) molecules . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Using reverse transcriptase polymerase chain reaction ( RT PCR ) and specific primers , mRNA for the cytolytic molecules perforin , granzyme A and B , Fas and Fas ligand ( FasL ) were detected in both the gammadelta and the alphabetaT cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis . ^^^ BACKGROUND : The Fas ligand / Fas receptor ( FasL / Fas ) system is an important mediator of apoptosis in the immune system where the juxtaposition of cells expressing the cell surface ligand induces the apoptotic pathway in Fas expressing lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Following TNF alpha up regulation , there was increased expression of Fas ( CD 95 ) and Fas ligand ( Fas L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas antigen is a cell surface receptor that triggers apoptosis when bound to Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas antigen is a receptor that triggers apoptosis when bound by Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Induction of apoptosis in placentas of pregnant mice exposed to lipopolysaccharides : possible involvement of Fas / Fas ligand system . ^^^ To explore the pathogenesis in placental dysfunction and abruptio placentae , we analyzed the occurrence of placental cell apoptosis and the role of Fas and Fas ligand ( L ) in that process in an inflammatory placental dysfunction model of pregnant mice , using lipopolysaccharides ( LPS ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas ligand expression in the ocular fluids of uveitis patients . ^^^ The expression of Fas ligand ( FasL ) in ocular tissues is thought to play a critical role in maintaining immune privilege in the eye . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The lack of NO production partially protected islets from cytokine induced apoptosis but had no effect on cell death induced by cell surface cross linking of Fas with soluble Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Whereas collagenase AP 1 / TRE dependent transcription was down regulated during apoptosis , Fas ligand promoter became activated . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Our results demonstrate that Fas antigen , Fas ligand , c myb , c myc , bcl 2 , Bax and p 53 mRNAs are present in lacrimal tissues of F 1 , NOD , C3H , BALB / c , Tabby and Tfm mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) and Fas ligand ( FasL ) play major roles in the homeostasis of the peripheral immune system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Indeed , short term treatment with IL 4 induces an increase in the expression of granzyme B and Fas ligand ( L ) in Valpha 14 NKT cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It has been reported that tumor cells treated with anticancer drugs increase surface expression of Fas ligand ( FasL ) and are killed by autocrine or paracrine apoptosis signaling through Fas ( Friesen , C . , 1 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas Fas ligand in murine testis . ^^^ In the present study , we investigated the expression and apoptotic role of Fas and Fas ligand ( L ) in the murine testis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TRAIL , the ligand for the newly discovered DR 4 and DR 5 receptor is a member of the tumour necrosis factor ( TNF ) family of death signal tranduction proteins with a mechanism of cell death , similar to the Fas and Fas ligand ( Fas L ) system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The role of transforming growth factor beta 1 ( TGF beta 1 ) induced extracellular matrix proteins in the modulation of cellular response to the cytotoxic effect of tumor necrosis factor ( TNF ) or Fas ligand was investigated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Structure and function of Fas / Fas ligand . ^^^ Fas ligand is biologically active as a homotrimer . ^^^ Since Fas / Fas ligand delete activated cells in the peripheral immune system , defects in this pathway predispose to autoimmune disorders . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Studies on lpr ( lymphoproliferation ) and gld ( generalized lymphoproliferative disease ) mice , which are loss of function mutant mice of Fas and Fas ligand ( FasL ) , respectively , show that these mutations are responsible for the early onset of systemic autoimmune disease in MRL mice , suggesting that autoreactive immunocytes are eliminated by the function of Fas / FasL system ( `` physiological function ' ' of Fas ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( Apo 1 , CD 95 ) cell surface antigen belongs to the tumor necrosis factor receptor family and mediates apoptosis of a variety of cell types , including lymphocytes , after ligation with Fas ligand ( FasL ) . ^^^ Fas ( Apo 1 , CD 95 ) cell surface antigen belongs to the tumor necrosis factor receptor family and mediates apoptosis of a variety of cell types , including lymphocytes , after ligation with Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis is triggered by a number of different stimuli including the activation of Fas antigen , a member of the TNF family , by the Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Bcl 2 does not inhibit cell death induced by the physiological Fas ligand : implications for the existence of type 1 and type 2 cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Using immunocytochemistry and Western blotting , we determined the expression of cyclin A protein as a measure of the proliferative activity and the pro apoptotic and anti apoptotic factors , Fas , Fas ligand , caspase 3 and Bcl 2 . ^^^ Of the newly diagnosed ALL , 88 % expressed the Fas ligand while such expression was observed in 54 % of the relapsed ALL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Notably , reconstitution with rIL 18 increased the numbers of cells staining for Fas ligand , as well as apoptotic cells stained by nick end labeling in bronchial submucosa infiltrates . ^^^ CONCLUSION : These findings indicate that in vivo IL 18 not only inhibited antigen specific T ( H 2 ) development but also affected apoptosis through Fas Fas ligand interactions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas and Fas ligand in cutaneous B cell lymphomas . ^^^ Fas Fas ligand ( Fasl ) expression was investigated in a group of primary and secondary CBCLs to gain an insight into the putative role of these apoptotic molecules in the clinical behaviour of these lymphomas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand in newly diagnosed childhood acute lymphoblastic leukemia . ^^^ Immunocytochemistry was used to analyze the expression of the Fas ligand ( FasL ) in sixty four children with newly diagnosed acute lymphoblastic leukemia ( ALL ) . ^^^ Children with newly diagnosed ALL and FasL expression exhibited longer relapse free and overall survival times under chemotherapy than did patients who did not express the Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunomodulating therapy with rIL 2 and interferon alpha induces in vivo expression of Bcl 2 , Fas ( APO 1 / CD95 ) , and Fas ligand on peripheral lymphocytes ( a pilot study ) . ^^^ We designed a prospective pilot study to evaluate in vivo effects of low dose IL 2 and IFN alpha combination on expression of Bcl 2 , FAS ( Apo 1 / CD 95 ) , Fas Ligand , IL 2 receptor ( CD 25 ) , and HLA DR on peripheral lymphocytes in patients with advanced renal cell carcinoma . ^^^ After initiation of the immunomodulating therapy , Bcl 2 expressing lymphocytes increased significantly on day 3 ( p < 0 . 025 ) , Fas ( Apo 1 / CD95 ) expressing lymphocyte increased significantly on day 5 ( p < 0 . 003 ) , Fas ligand expressing lymphocytes increased significantly on day 3 ( p < 0 . 004 ) , HLA DR expressing lymphocytes increased significantly on day 5 ( p < 0 . 003 ) , and IL 2 receptor ( CD 25 ) expressing cells increased significantly on day 5 ( p < 0 . 01 ) . ^^^ We conclude that immunomodulating therapy induces in vivo expression of Bcl 2 , Fas ( Apo 1 ) and Fas Ligand in lymphocytes significantly . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The interaction of Fas ( APO 1 / CD95 ) and the Fas ligand system induces apoptosis . ^^^ However , the role of the Fas / Fas ligand system in normal physiological liver cell death remains to be determined . ^^^ Using northern blotting analysis , we investigated the role of Fas and Fas ligand mRNA expression in liver regeneration in rats until 14 days after partial hepatectomy . ^^^ However , partial hepatectomy did not affect the expression of Fas ligand mRNA levels . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Many cells , including eosinophils , express CD 95 ( Fas ) , a surface receptor that mediates apoptosis when ligated by specific antibodies or its natural ligand , Fas ligand ( FasL ) . ^^^ Effects of interferon gamma and tumour necrosis factor alpha on CD95 / Fas ligand mediated apoptosis in human blood eosinophils . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand , death gene . ^^^ Induction of an apoptotic cascade via activation of caspases , selective release of mitochondrial proteins and further activation of caspases , can be stimulated by engagement of the Fas surface molecule via membrane bound or soluble forms of Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A multistep pathogenesis is proposed . ( 1 ) Targeted injury or mutation within hemopoietic stem cells may be followed by an immunologic response adversely affecting progenitor survival . ( 2 ) Accelerated proliferation and premature death of marrow cells is amplified by apoptogenic cytokines ( TNF alpha , Fas ligand ) . ( 3 ) Establishment of an abnormal clone associated with telomere shortening . ( 4 ) Disease progression associated with loss of tumor suppressor activity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas and Fas ligand on both thymocytes and peripheral T cells was upregulated in transgenic mice , but the increased apoptosis in the thymus was independent of Fas ( CD 95 ) , whereas peripheral spleen and lymph node T cell apoptosis was Fas dependent . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Menadione also induced a T antigen dependent cleavage of Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide inhibit antigen induced apoptosis of mature T lymphocytes by inhibiting Fas ligand expression . ^^^ AICD is initiated by Ag re engagement of the TCR and is mediated through Fas / Fas ligand ( FasL ) interactions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas or Fas ligand ( FasL ) deficient mice are relatively resistant to the induction of experimental allergic encephalomyelitis , implying the involvement of Fas / FasL in this disease process . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Analysis of fas ligand gene mutation in patients with systemic lupus erythematosus . ^^^ OBJECTIVE : To investigate the possible association of a Fas ligand ( FasL ) gene mutation ( s ) or polymorphism ( s ) with systemic lupus erythematosus ( SLE ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Induction of Fas and Fas ligand expression in plasmacytoma cells by a cytotoxic factor secreted by murine macrophages . ^^^ In this report , the involvement of Fas and Fas ligand ( FasL ) in PCF induced apoptosis was investigated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Production of AdFasL / G , an adenovirus vector that expresses high levels of Fas ligand , was severely reduced in the 293 packaging cell line . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NO aspirin prevented Fas , Fas ligand , and IL 2 receptor up regulation on spleen lymphocytes and Fas ligand on hepatocytes and caused the S nitrosylation / inhibition of IL 1beta converting enzyme like cysteine proteases ( caspases ) involved in the processing and maturation of IL 1beta and IL 18 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression in esophageal carcinomas and their lymph node metastases . ^^^ BACKGROUND : Although esophageal adenocarcinomas ( EADCA ) have been shown to have substantially reduced or absent Fas expression , the status of Fas ligand ( FasL ) in these tumors , especially adenocarcinomas , is largely unknown . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand , which is a type 2 membrane protein , is a major inducer of apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Sensitivity of testicular germ cells to toxicant induced apoptosis in gld mice that express a nonfunctional form of Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Blocking monoclonal antibody to Fas ligand partially prevented the staphylococcal enterotoxin B induced apoptosis detected by APO2 . 7 expression and Hoechst 33258 staining . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas or Fas ligand ( FasL ) expression was tested by surface staining with specific mAbs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble human MHC class 1 molecules induce soluble Fas ligand secretion and trigger apoptosis in activated CD 8 ( + ) Fas ( CD 95 ) ( + ) T lymphocytes . ^^^ Apoptosis is induced by the interaction of Fas ( CD 95 ) ( + ) cells with soluble Fas ligand which is released following binding of sHLA 1 antigens to CD 8 molecules . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas Fas ligand system plays an important role in cytotoxic T lymphocyte mediated or natural killer cell mediated cytotoxicity against tumor cells . ^^^ Soluble Fas ( sFas ) , generated by alternative splicing , has been reported to antagonize the interaction of cell surface Fas with Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The contribution of FAS and FAS ligand mediated apoptosis was assessed via bioluminescent reverse transcription polymerase chain reaction ( RT PCR ) , immunohistochemical staining , and TUNEL assessment of DNA fragmentation . ^^^ A / J mice also had elevated levels of FAS and FAS ligand message and protein early after infection , while the C57BL / 6 mice had no increased expression of these molecules . ^^^ It is therefore proposed that apoptosis during initial granuloma formation following MTB infection may occur through a FAS / FAS ligand independent pathway . ^^^ Moreover , a failure of completion of the FAS / FAS ligand mediated apoptosis pathway in the A / J mice may contribute to inefficient elimination of lymphocytes , thus further aggravating pulmonary pathology . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Up regulation of Fas and Fas ligand and excessive apoptosis of bronchiolar and alveolar epithelial cells were identified in bleomycin induced pulmonary fibrosis in mice . ^^^ This study hypothesized that apoptosis regulatory genes other than Fas Fas ligand , such as p 53 , p 21 ( Waf1 / Cip1 ) , bcl 2 , bcl 10 , and bax , may also participate in epithelial cell apoptosis in this model . ^^^ It is concluded that epithelial cell apoptosis in this model may also be induced by the up regulation of p 53 and bax and by the imbalance between apoptosis inducible and inhibitory genes , in addition to the up regulation of the Fas Fas ligand pathway . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Transgenic expression of Fas ligand on thyroid follicular cells prevents autoimmune thyroiditis . `` Immune privilege ' ' is defined as tissue resistance to aggression by specifically activated lymphocytes , and involves the interaction between Fas expressed on infiltrating cells and Fas ligand ( FasL ) constitutively expressed on the target tissue . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We studied the possible role of two prominent nerve growth factor ( NGF TNF ) family member systems , Fas ligand ( FasL ) Fas receptor ( FasR ) and TNF alpha TNFR , in apoptosis of murine CD8+4+ double positive ( DP ) thymocytes induced via TCR CD 3 and cAMP mediated signaling . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The use of gld / gld macrophages excluded a role for Fas ligand in this residual kill , despite increased expression of Fas and increased susceptibility to soluble Fas ligand exhibited by cytokine primed mesangial cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the surviving mice that had been treated with ST40L , a small and hard nodule was formed at the injection site , which was found to be composed of infiltrating lymphocytes expressing Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand in arteries of hypercholesterolemic rabbits accelerates atherosclerotic lesion formation . ^^^ Fas ligand ( FasL ) is expressed by cells of the arterial wall and is present in human atherosclerotic lesions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Vascular endothelial cells and smooth muscle cells differ in expression of Fas and Fas ligand and in sensitivity to Fas ligand induced cell death : implications for vascular disease and therapy . ^^^ Fas ligand ( FasL ) is a death factor that induces apoptosis in cells bearing its receptor , Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
All cases expressed cytotoxicity associated molecules ( perforin , granzyme B , TIA 1 and Fas ligand ) . ^^^ However , perforin and Fas ligand were not detected in one case . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These ' killer ' cells belong to the T helper type 1 ( Th 1 ) subset and if activated , express Fas ligand ( FasL ) which induces apoptosis in Fas positive target cells . ^^^ Furthermore , Fas ligand expressing tumors can evade the attack of Fas positive CD4+ CTL and other effector cells , thereby giving them an opportunity to expand . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( CD 95 ) and Fas ligand ( FasL ) are a receptor / ligand pair critically involved in lymphocyte homeostasis and peripheral tolerance such that genetic defect in either Fas or FasL results in an autoimmune lymphoproliferative syndrome . ^^^ Fas ( CD 95 ) and Fas ligand ( FasL ) are a receptor / ligand pair critically involved in lymphocyte homeostasis and peripheral tolerance such that genetic defect in either Fas or FasL results in an autoimmune lymphoproliferative syndrome . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : After gastric epithelial cells were infected with H . pylori in the presence of immune mediators , including tumor necrosis factor alpha ( TNF alpha ) and Fas ligand ( FasL ) , apoptosis and caspase 3 activity were assessed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Chloro 2 ' deoxyadenosine induces apoptosis through the Fas / Fas ligand pathway in human leukemia cell line MOLT 4 . ^^^ The protein synthesis dependent expression of Fas and Fas ligand ( Fas L ) was detected by treatment with 2CdA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Fas ligand mediated apoptosis of murine Langerhans cells . ^^^ The Fas / Fas ligand pathway has been implicated as an important cellular pathway in the regulation of peripheral immunity . ^^^ Interestingly , epidermal LC underwent apoptosis by the addition of both recombinant soluble Fas ligand ( FasL ) and IFN gamma , but not by FasL alone . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Promising therapeutic effects have been obtained in animal models of restenosis or vein graft thickening with the transfer of genes coding for VEGF , nitric oxide synthase , thymidine kinase , retinoblastoma , growth arrest homoeobox , tissue inhibitor of metalloproteinases , cyclin or cyclin dependent kinase inhibitors , fas ligand and hirudin , and antisense oligonucleotides against transcription factors or cell cycle regulatory proteins . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Treatment of lupus in NZB / W F 1 mice with monoclonal antibody against Fas ligand . ^^^ Since Fas ligand ( FasL ) can induce apoptosis of Fas bearing cells , Fas / FasL interactions can play a critical role in maintaining self tolerance . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The dual functions of fas ligand in the regulation of peripheral CD8+ and CD4+ T cells . ^^^ Although Fas ligand ( FasL ) is well characterized for its capacity to deliver a death signal through its receptor Fas , recent work demonstrates that FasL also can receive signals facilitating antigen ( Ag ) specific proliferation of CD 8 ( + ) T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
When exposed to Fas ligand , RGM 1 cells treated with PBMC conditioned medium underwent massive and rapid cell death , interestingly , with a minimal effect on total cell numbers early on . ^^^ Cell cycle analysis revealed a substantial increase in S phase cells among cells exposed to Fas ligand , suggesting an increase in their proliferative response . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Evidence for Fas mediated lysis of beta cells in the pathogenesis of IDDM in nonobese diabetic ( NOD ) mice includes : 1 ) Fas deficient NOD mice bearing the lpr mutation ( NOD lpr / lpr ) fail to develop IDDM ; 2 ) transgenic expression of Fas ligand ( FasL ) on beta cells in NOD mice may result in accelerated IDDM ; and 3 ) irradiated NOD lpr / lpr mice are resistant to adoptive transfer of diabetes by cells from NOD mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand gene carrying adeno 5 AdEasy viruses can be efficiently propagated in apoptosis sensitive human embryonic retinoblast 911 cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , cisplatin did not induce the expression of Fas ligand mRNA or upregulation of Fas protein . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Molecular characterization of the mouse Fas ligand promoter in airway epithelial cells . ^^^ Constitutively expressed Fas ligand in several distinct epithelial cell types appears to protect tissues by inducing apoptosis of Fas ( + ) immune cells during inflammatory reactions . ^^^ To study the transcriptional regulation of Fas ligand gene in airway epithelial cells , a 618 bp 5 ' flanking region of mouse Fas ligand gene was cloned , sequenced , and the transcriptional start site was determined by using 5 ' RACE . ^^^ This element was not required for constitutive Fas ligand expression in Sertoli cells . ^^^ UV cross linking proteins to this element indicated that a approximately 23 kDa transcription factor bound to the Fas ligand promoter CCAAT box and , thus , likely plays an important role in the regulation of Fas ligand expression in airway epithelial cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A single cell analysis of Fas ligand positive T cells in rheumatoid synovial fluid . ^^^ OBJECTIVE : To investigate the function of Fas ligand ( Fas L ) positive T cells in rheumatoid synovium , we analyzed the T cell receptor ( TCR ) CDR 3 region and examined the expression of cytokines in both Fas L+ and Fas L single T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Elucidation of the signal transduction mechanism revealed involvement of protein tyrosine kinase , protein kinase C and ser / thr phosphatases with concomitant increase in the level of protein products of apoptosis associated genes p 53 , bax , bad , fas and fas ligand and cleavage of N terminal 23 kDa fragment of Bcl 2 that exhibited Bax like death effector properties . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Induction of apoptosis in glioma cells by recombinant human Fas ligand . ^^^ OBJECTIVE : Fas ligand ( FasL ) belongs to the tumor necrosis factor family and has the ability to induce apoptosis in susceptible target cells by binding to its receptor , Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of HLA DR , costimulatory molecules B 7 1 , B 7 2 , intercellular adhesion molecule 1 ( ICAM 1 ) and Fas ligand ( FasL ) on gastric epithelial cells in Helicobacter pylori gastritis ; influence of H . pylori eradication . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Caspase induced inactivation of the anti apoptotic TRAF 1 during Fas ligand mediated apoptosis . ^^^ Here we show that TRAF 1 is cleaved after Asp 163 when cells are induced to undergo apoptosis by Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Overexpression of Fas ligand by neuroblastoma : a novel mechanism of tumor cell killing . ^^^ BACKGROUND / PURPOSE : Binding of Fas ligand ( Fas L ) to the membrane bound Fas receptor incites a series of intracellular events that results in programmed cell death or apoptosis . ^^^ Fas Ligand transfectants induced apoptosis in 17 . 6 % + / 2 . 9 % of Fas sensitive T cells , whereas controls induced apoptosis in only 2 . 8 % + / 1 . 2 % ( P = . 01 , n = 3 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Inhibition of solid tumor growth by Fas ligand expressing myoblasts . ^^^ Here we show that myoblasts from skeletal muscle that have been engineered with retroviral vectors to express Fas ligand ( FasL ) have potential as site specific anti tumor agents . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
While the TCR triggered signaling initiates both perforin and Fas ligand ( FasL ) Fas mediated mechanisms of cytotoxicity , it was not clear which mechanism was utilized by Thy 1 triggered signals and which pathway of cytotoxicity was triggered at low levels of antigen expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Up regulation of Fas ligand and down regulation of Fas expression in oral carcinogenesis . ^^^ When another molecule called the Fas ligand ( FasL ) binds to it , Fas triggers a series of events inside the cell that leads to apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Additionally , no production of fas ligand , tumor necrosis factor alpha or interferon gamma in LS 801 was observed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Programmed cell death ( apoptosis ) is primarily mediated by Fas ligand ( FasL ; CD95L ) and the Fas receptor ( Fas ; CD 95 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Following this infection , induction of Fas ligand ( FasL ) , tumor necrosis factor alpha ( TNF alpha ) , and perforin mRNA are all demonstrable in the liver , pointing to a role of respective pathways in liver injury . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Previous reports indicate that Fas Fas ligand interactions are the principle molecules mediating this response . ^^^ However , D 10 , an Iak restricted cloned Th 2 line , will similarly induce apoptosis in Ag presenting macrophages , and D 10 cells lack Fas ligand . ^^^ Further studies demonstrated that AE 7 , a cloned Th 1 line , and splenic T cells express TWEAK , TRAIL , and Fas ligand , and inhibiting these molecules also inhibited macrophage killing . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Inhibition of autoimmune diabetes by Fas ligand : the paradox is solved . ^^^ Previous reports that diabetogenic lymphocytes did not induce diabetes in nonobese diabetic ( NOD ) lpr mice suggested the critical role of Fas Fas ligand ( FasL ) interaction in pancreatic beta cell apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Engagement of the alpha2beta1 integrin inhibits Fas ligand expression and activation induced cell death in T cells in a focal adhesion kinase dependent manner . ^^^ Mechanistically , AICD has been largely attributed to the interaction of Fas ligand ( Fas L ) with its cell surface receptor Fas in activated T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Coexpression of FAS and FAS ligand in chronic pancreatitis : correlation with apoptosis . ^^^ Activation of the Fas receptor by Fas ligand ( FasL ) results in apoptosis , and dysregulation of this pathway may contribute to abnormal cell proliferation and cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand are not involved in the suppression of HIV replication by CD 8 cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Labor associated changes in Fas ligand expression and function in human placenta . ^^^ Fas ligand ( FasL ) dependent apoptosis has been implicated in the control of tissue damaging inflammatory responses in several immune privileged sites . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased levels of soluble Fas receptor and Fas ligand in the cerebrospinal fluid of HIV infected patients . ^^^ Analyses of serum samples and blood cells have revealed a dysregulation of the Fas / Fas ligand ( FasL ) system during HIV infection , which may be related to disease progression . ^^^ Soluble Fas was detected in 38 of 56 ( 68 % ) and soluble Fas ligand in 17 of 56 ( 30 % ) CSF samples from HIV infected patients . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
PURPOSE : To investigate whether Fas ligand ( FasL ) and the Fas receptor system mediates apoptosis in cultured human retinal pigment epithelial ( hRPE ) cells and contributes to oxidant induced death of hRPE cells . ^^^ The susceptibility of hRPE cells to Fas mediated apoptosis was determined by incubating cells with recombinant soluble Fas ligand ( sFasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
PURPOSE : To investigate the role of apoptosis in immunopathogenic mechanisms of experimental autoimmune uveoretinitis ( EAU ) , the kinetics of apoptotic cells and expression of Fas and Fas ligand ( FasL ) in the eye with EAU were studied . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand in gut and liver . ^^^ Perhaps the best studied death receptor and ligand system is the Fas / Fas ligand ( FasL ) system , in which FasL , a member of the tumor necrosis factor ( TNF ) family of death inducing ligands , signals death through the death receptor Fas , thereby resulting in the apoptotic death of the cell . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Both of the studied subclones expressed the Fas receptor ( FasR ) , but only the ER cell line expressed the Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Serum soluble Fas ligand ( sFasL ) was found to be elevated to a concentration of 0 . 395 ng / ml at the time of liver damage , but was less than 0 . 03 ng / ml before liver damage and after prednisolone treatment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Evaluation of restenosis by serum levels of soluble Fas , Fas ligand and nuclear matrix protein before and after coronary intervention ] . ^^^ Serum levels of soluble Fas , soluble Fas ligand , and nuclear matrix protein ( NMP ) were measured in 38 patients with ischemic heart disease before and after coronary angiography or coronary intervention . ^^^ Serum levels of soluble Fas , soluble Fas ligand and NMP were determined by enzyme linked immunosorbent assay . ^^^ Patients one week after undergoing stent implantation had much higher levels of soluble Fas ligand and significantly lower levels of soluble Fas than patients without coronary intervention . ^^^ Serum levels of soluble Fas ligand and NMP in patients with coronary restenosis were significantly higher than those in patients without restenosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
GnRH has also been demonstrated to increase Fas ligand expression within plasma membrane , which is known to promote apoptotic cell death through attack on Fas positive cells within tumors . ^^^ The Fas Fas ligand complex might , at least in part , account for the antiproliferative action of the hormone . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand expression in human pancreatic cancer . ^^^ SUMMARY BACKGROUND DATA : Activation of the Fas receptor by Fas ligand ( FasL ) results in apoptosis , and dysregulation of this pathway may contribute to abnormal cell proliferation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Notably , genes involved in cell death , even thymocyte death , such as Fas , Fas ligand , p 53 , caspase 1 , caspase 3 , and caspase 9 , and Bcl 2 have been found to not be required for normal thymic negative selection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The cardiac Fas ( APO 1 / CD95 ) Receptor / Fas ligand system : relation to diastolic wall stress in volume overload hypertrophy in vivo and activation of the transcription factor AP 1 in cardiac myocytes . ^^^ Cross linking of Fas by Fas ligand ( FasL ) , a tumor necrosis factor alpha related cytokine , promotes apoptosis and / or transcription factor activation in a highly cell type specific manner . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Human astrocytomas co expressing Fas and Fas ligand also produce TGFbeta 2 and Bcl 2 . ^^^ Human astrocytomas frequently co express Fas ( APO 1 / CD95 ) and Fas ligand ( FasL ) , yet do not appear to be overly susceptible to suicidal , fratricidal and immune mediated elimination . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Using genetically engineered mice deficient in the aSMase gene ( aSMase ( / ) ) , we found that thymocytes , concanavalin A activated T cells , and lipopolysaccharide activated B cells derived from both aSMase ( / ) and aSMase ( + / + ) mice were equally sensitive to Fas mediated cell death , triggered by either anti Fas antibody or Fas ligand in vitro . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activated T cells undergo apoptosis upon expression and ligation of Fas ligand ( FasL ) to Fas / APO 1 ( CD 95 ) receptor . ^^^ The IFN regulatory factor family participates in regulation of Fas ligand gene expression in T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis and apoptosis related proteins ( Fas , Fas ligand , Blc 2 , p 53 ) in lymphoid elements of human ovarian tumors . ^^^ Thus , their expression of apoptosis related proteins ( ARP Fas and Fas ligand , bcl 2 , p 53 ) in lymphocytes and their apoptosis were analyzed immunohistochemically in ovarian tumors of different grades . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , IL 18 enhances intracellular adhesion molecule 1 ( ICAM 1 ) expression as well as Fas ligand ( FasL ) expression , and induces apoptosis in hepatic injury . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Antigen presenting cells expressing Fas ligand down modulate chronic inflammatory disease in Fas ligand deficient mice . ^^^ We assessed the effect of modified antigen presenting cells ( APCs ) expressing high levels of Fas ligand ( APC FasL ) on post viral chronic inflammatory disease . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Carvedilol prevents epinephrine induced apoptosis in human coronary artery endothelial cells : modulation of Fas / Fas ligand and caspase 3 pathway . ^^^ Since there is evidence for elevation of catecholamine levels in plasma and coronary artery endothelial cell injury in CHF , the present study was designed to test the hypothesis that carvedilol inhibits epinephrine induced apoptosis , and the inhibitory effect is mediated by modulation of Fas , Fas ligand ( FasL ) and caspase 3 pathway , in cultured human coronary artery endothelial cells ( HCAECs ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We report that thymocytes from mice lacking functional Fas ligand ( gld ) show normal sensitivity to apoptosis transduced by p 53 , and that hepatocytes fromp 53 / mice have normal sensitivity to apoptosis triggered through ligation of CD 95 . p 53 and CD 95 , therefore , function in independent pathways to cell death in these diverse cell types . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This bystander sensitization was in part dependent on the expression of Fas ligand ( FasL ) on the activated virus specific cells and gamma interferon ( IFN gamma ) receptor expression on the bystander T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We therefore investigated the regulation by beta endorphin of cytotoxicity associated molecules such as granzyme B , perforin , and Fas ligand ( FasL ) in human CD 16 ( + ) NK cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Granule exocytosis , and not the fas / fas ligand system , is the main pathway of cytotoxicity mediated by alloantigen specific CD 4 ( + ) as well as CD 8 ( + ) cytotoxic T lymphocytes in humans . ^^^ Messenger RNAs for the major mediators of CTL cytotoxicity , Fas ligand , perforin , and granzyme B were all detected in these CD 4 ( + ) CTLs with the use of the reverse transcriptase polymerase chain reaction . ^^^ These data , obtained with the use of a novel experimental system , clearly show that the main pathway of cytotoxicity mediated by alloantigen specific human CD 4 ( + ) as well as by CD 8 ( + ) CTLs is granule exocytosis , and not the Fas / Fas ligand system . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
As well as effluxing xenotoxins , functional P gp can confer resistance to caspase dependent apoptosis induced by a range of different stimuli , including Fas ligand , tumor necrosis factor , UV irradiation , and serum starvation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand in activated T cells is regulated by c Myc . ^^^ Here we demonstrate that T cell activation induced expression of Fas ligand ( FasL , CD 95 L , APO 1 L ) , which can induce apoptotic cell death in many different cell types , is regulated by c Myc . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The status of Fas and Fas ligand expression can predict recurrence of hepatocellular carcinoma . ^^^ The status of Fas and Fas ligand ( Fas L ) expression was investigated in this study for 103 hepatocellular carcinomas ( HCC ) . ^^^ These results suggest that the evaluation of Fas and Fas ligand expression potentially has a significant prognostic value for DFS of HCC patients , in addition to the clinical stage , and can be regarded as a new prognostic marker . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Monocytes express cytotoxic factors of the tumour necrosis factor ( TNF ) ligand superfamily , including TNF and Fas ligand , both on the cell surface and in secreted form . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To further assess the relationship between serum concentrations of adhesion or apoptotic related soluble structures and liver diseases , we evaluated the levels of intercellular adhesion molecule 1 ( sICAM 1 ) , Fas receptor ( CD 95 ) and Fas ligand ( sCD95L ) in a group of patients affected by Hepatitis C Virus ( HCV ) induced chronic hepatitis ( CH C ) , HCV positive liver cirrhosis with superimposed hepatocellular carcinoma ( HCC ) , autoimmune hepatitis ( AIH ) , primary biliary cirrhosis ( PBC ) and alcoholic liver cirrhosis ( ALC ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Analysis of Fas and Fas ligand expression and function in lung cancer cell lines . ^^^ The aim of this study was to investigate the expression of Fas and Fas ligand ( FasL ) and to determine the significance of these molecules in lung cancer cell lines . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Radiation induced expression of functional Fas ligand in EBV positive human nasopharyngeal carcinoma cells . ^^^ Both the Fas receptor and the Fas ligand were found to be functional in this model , and a high proportion of irradiated NPC cells underwent apoptosis following tumor irradiation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interferon gamma induces apoptosis and augments the expression of Fas and Fas ligand by microglia in vitro . ^^^ Flow cytometry was used to quantify the IFN gamma mediated apoptotic response and Fas and Fas ligand ( FasL ) expression in two well characterized murine microglia cell lines ( BV 2 and N 9 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Several reports have suggested that anticancer drugs kill susceptible cells by inducing expression of death receptor ligands , especially Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , when these same cells revert to a resting phenotype and are subjected to restimulation with either SEB or anti CD 3 , the majority of these SEB responsive cells undergo Fas ligand ( FasL ) mediated activation induced cell death ( AICD ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We show here that CD4+ CD8alphaalpha+ 1 IEL belongs to Th 1 type T cells capable of responding to self MHC class 1 on 1 EC and that a significant fraction of 1 IEL expressed Fas ligand ( Fas L ) and induced apoptosis in the 1 EC via Fas dependent pathway . 1 IEL may recognize and eliminate the effete 1 EC for homeostatic regulation of intestinal epithelia . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Leukemic LGL constitutively express Fas and Fas Ligand but they are resistant to Fas induced apotosis . ^^^ Neutropenia could be due to soluble Fas Ligand which is highly secreted in the patient ' s sera . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We evaluated the degree of apoptosis of peripheral blood mononuclear cells ( PBMC ) in KD and investigated whether the Fas Fas ligand system is involved in inducing apoptosis in KD . ^^^ The levels of serum soluble Fas were measured by ELISA . mRNA expression of Fas ligand was evaluated by reverse transcription polymerase chain reaction . ^^^ CONCLUSION : Marked decrease of peripheral blood lymphocytes in acute stage KD may be caused by the upregulated apoptosis of lymphocytes ; Fas Fas ligand may be involved in this upregulation . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although induction of Fas mediated apoptosis could have therapeutic effects on these diseases , it might cause deleterious effects in liver as Fas ligand or an agonistic anti murine Fas antibody Jo 2 causes severe hepatic injury in mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
During thymineless stress in TS ( ) cells , Fas ligand ( FasL ) is expressed , and its promoter ( hFasLPr ) is activated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ceramide induced cell death is independent of the Fas / Fas ligand pathway and is prevented by Nur 77 overexpression in A 20 B cells . ^^^ While in some experimental systems , ceramide was shown to mediate Fas induced cell death , in other instances it was claimed to induce the expression of Fas ligand ( FasL ) , killing cells in a caspase dependent fashion . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Opposing effects of transmembrane and soluble Fas ligand expression on inflammation and tumor cell survival . ^^^ Fas ligand ( FasL ) has been shown to mediate both apoptotic and inflammatory reactions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , little is known about the underlying mechanisms responsible for the increased apoptosis of lymphoid and parenchymal cells in solid organs and the role played by inflammatory mediators , such as tumor necrosis factor alpha ( TNF alpha ) and Fas ligand ( FasL ) , as well as by glucocorticoids . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , CML progenitor cells also express functional Fas ligand ( Fas L ) , which may be an important immune surveillance escape factor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
There is evidence , however , that regulatory molecules such as tumor necrosis factor ( TNF ) alpha , Fas ( CD 95 ) , and Fas ligand , which negatively affect hemopoiesis by way of apoptosis are upregulated . ^^^ Here we analyzed marrow samples from 80 patients with MDS in regard to TNF alpha and Fas ligand levels and a possible correlation with various disease parameters and risk factors . ^^^ However , there was an inverse correlation between the cytogenetic risk category ( low , intermediate , high ) and levels of soluble Fas ligand . ^^^ Limiting dilution analysis of CD34+ precursor cells showed that individually assayed cells , removed from companion cells that presumably provided negative signals such as TNF alpha or Fas ligand , were able to generate progressively increasing numbers of colonies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
An Sp 1 binding site involves the transcription of the Fas ligand gene induced by PMA and ionomycin in Jurkat cells . ^^^ The transcriptional regulation of the Fas ligand ( FasL ) gene in Jurkat cells was investigated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas ligand ( FasL ) and its receptor Fas ( APO 1 or CD 95 ) are members , respectively , of the tumor necrosis factor family that , upon interaction with each other , play a key role in the initiation of one apoptotic pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Transformed and nontransformed cells expressing MHC class 1 , CD 5 , CD 3 , CD 4 , CD 6 , CD 7 , CD 34 , CD 45 , MHC class 2 , Fas ligand , and phosphatidylserine were assessed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : Our previous studies have shown that the ability of donor bone marrow to augment skin graft survival in antithymocyte serum ( ATS ) treated recipients is dependent on the presence of functional CD 95 ligand ( Fas ligand ) molecules on donor cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We conclude that the CD 40 ligand expressed by activated T cells first enhances MV replication in DCs , and then Fas ligand produced by activated T cells induces Fas mediated apoptosis of DCs , thus facilitating MV release . ( 2 ) Not only MV infected DCs but also bystander uninfected DCs undergo a maturation process confirmed by CD1a , CD 40 , CD 80 , CD 86 , CD 83 , and major histocompatibility complex type 2 labeling . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Estrogen regulated developmental neuronal apoptosis is determined by estrogen receptor subtype and the Fas / Fas ligand system . ^^^ Moreover , we show that estrogen induced apoptosis through ER beta requires the expression of Fas and Fas ligand ( FasL ) proteins , since the absence of FasL in neurons prevents this effect . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
When HCV specific T cells migrate into hepatocytes and recognize the viral antigen via the T cell receptor , they become activated and express Fas ligand that transduces the apoptotic death signal to Fas bearing hepatocytes resulting in their destruction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptotic depletion of infiltrating mucosal lymphocytes associated with Fas ligand expression by Helicobacter pylori infected gastric mucosal epithelium : human glandular stomach as a site of immune privilege . ^^^ To confirm the recent data obtained in testis and eye , showing that Fas ligand is involved in the phenomenon of `` immune privilege , ' ' expression of Fas receptor and its ligand of the stomach was investigated in a panel of gastric biopsies obtained from patients H . pylori positive ( N = 42 ) and with H . pylori negative ( N = 18 ) by two color flow cytometry . ^^^ The results show that membrane bound Fas ligand protein is constitutively expressed on freshly isolated human gastric mucosal epithelium coupled with infiltrating lymphocytes . ^^^ However , the more specific findings are apoptotic depletion of invading mucosal lymphocytes associated with Fas ligand expression by gastric epithelium . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , the cells contained a cytolytic granule associated protein , TIA 1 , and Fas ligand , indicating cytotoxic T cell differentiation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand has been suggested as a general underlying mechanism of immune privilege ; the human Fas ligand has been shown to ligate murine Fas in vitro . ^^^ RESULTS : Unlike in rodent testis , Fas ligand mRNA is not expressed and Fas is highly expressed in human testis . ^^^ CONCLUSIONS : Our results demonstrate that the concept of immune privilege , as defined by the expression of Fas ligand and prolonged survival after transplantation , can not be extended to human testis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : To examine the role of fas fas ligand interaction and apoptosis in acute transplant rejection . ^^^ METHODS : Pre and posttransplant renal allograft biopsies were stained by in situ 3 end labeling of DNA for detection of apoptotic cells ( TUNEL ) and immunohistochemistry techniques were used for demonstration of fas and fas ligand antigen expression . ^^^ Fas and fas ligand expression was demonstrated predominantly in the tubular epithelium . ^^^ Fas ligand was expressed by 30 % ( 11 / 37 ) of preimplant biopsies , posttransplantation expression was reduced in all groups : 17 % ( 3 / 18 ) acute rejection , 13 % ( 1 / 8 ) acute tubular necrosis , delayed xenograft rejection and 15 % ( 2 / 13 ) dysfunction without evidence of rejection . ^^^ The expression of fas ligand preimplantation correlated with an absence of acute rejection episodes posttransplant , suggesting some degree of immune privilege . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Frequent expression of soluble Fas and Fas ligand in Chinese stomach cancer and its preneoplastic lesions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Serum concentrations of soluble Fas antigen and soluble Fas ligand in mother and newborn . ^^^ We measured soluble Fas antigen and soluble Fas ligand , which are considered to be an apoptotic substance , in maternal serum , umbilical cord serum and amniotic fluid during cesarean section at full term pregnancy . ^^^ Soluble Fas ligand showed a difference , in which umbilical serum level was significantly higher than maternal serum and amniotic fluid levels . ^^^ The present results suggest high serum levels of soluble Fas ligand in newborn . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , the expression patterns of the FasAg and Fas ligand were similar in umbilical artery and aorta . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We have analyzed the expression of the tumor associated sialyl LewisA ( sLeA ) and sialyl LewisX ( sLeA ) antigens , the complement restriction factors ( CD 59 , CD 46 and CD 55 ) and the apoptosis associated factors Fas and Fas Ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptotic bodies were counted under a fluorescence microscope , and immunostaining was performed using anti Fas , Fas ligand , Bcl 2 , Bax , and p 53 antibodies . ^^^ On immunostaining , the incidence of stained cells with anti Fas , Fas ligand , Bax , and p 53 antibody was increased after 24 h incubation without addition . ^^^ Our results also suggest that Fas , Fas ligand , p 53 , and Bax may play roles in this apoptosis controlled by hCG , TGFbeta 1 , and M CSF . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Adenovirus mediated transfer of caspase 3 with Fas ligand induces drastic apoptosis in U 373MG glioma cells . ^^^ Next , we investigated whether overexpression of caspase 3 could enhance Fas ligand mediated apoptosis in these four cell lines . ^^^ In U 373MG cells , which showed the highest level of expression of surface Fas among the four cell lines , coinfection of the Adv for caspase 3 ( Adv caspase 3 ) and the Adv for Fas ligand ( Adv FL ) induced a remarkably increased degree of apoptosis compared with that induced by the single infection of either Adv caspase 3 or Adv FL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The immunohistochemical localization of Fas and Fas ligand in jaw bone and tooth germ of human fetuses . ^^^ In this study , BMP 2 , osteocalcin , and TGF beta , which are bone differentiating markers , apoptosis associating factors ( i . e . , Bcl 2 , Bax , Fas , and Fas ligand ) , apoptotic cells detected by the in situ 3 ' end labeling method ( TUNEL ) , and proliferating cell nuclear antigen ( PCNA ) were immunohistochemically examined in the heads ( in particular , the jaw bone and tooth germs ) of human fetuses of 11 week pregnancy . ^^^ In contrast , Fas ligand was positive in the cytoplasm of osteoblasts and abundant in the stroma of the osteoblastic layer , periosteum , and perichondrium . ^^^ The Fas ligand in the stroma was recognized as the soluble form , which was possibly produced by osteoblasts . ^^^ The induction of apoptosis observed in monocytes seems to be caused via a Fas Fas ligand cell death system , because some of these monocytes were Fas positive , and most of them were Fas ligand positive . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Plasma soluble Fas ( APO 1 , CD 95 ) and soluble Fas ligand in immune thrombocytopenic purpura . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas and Fas ligand after experimental traumatic brain injury in the rat . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL , CD95L ) induces apoptosis in activated T cells with upregulated Fas ( CD 95 ) expression through the process termed activation induced cell death ( AICD ) . ^^^ Antigen specific induction of peripheral T cell tolerance in vivo by codelivery of DNA vectors encoding antigen and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The interaction between CD 95 ( Fas ) and CD95L ( Fas ligand ) initiates apoptosis in a variety of cell types . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expressions of Fas ligand and other apoptosis related genes and their prognostic significance in epithelial ovarian neoplasms . ^^^ Expression of apoptosis related proteins , bcl 2 , Bax , Fas and Fas ligand ( L ) , in ovarian epithelial neoplasms together with its clinical relevance was examined by immunohistochemistry . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The role of fas ligand in vivo as a cause and regulator of pathogenesis . ^^^ Recent studies have significantly advanced our understanding of the physiological and pathogenic functions of Fas and Fas ligand ( FasL ) in vivo . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND AND OBJECTIVE : Fas ligand ( FasL , CD95L ) is a type 2 transmembrane protein of the tumor necrosis factor family that induces cells to send an apoptotic signal to cells expressing Fas ( CD 95 , APO 1 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tumor derived Fas ligand induces toxicity in lymphoid organs and plays an important role in successful chemotherapy . ^^^ Recent studies have suggested that Fas ligand ( FasL ) tumor cells can induce apoptosis in Fas+ T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Using RT PCR , immunoflow cytometry and immunoelectron microscopy , the cytotoxic potential of isolated human decidual gammadelta T cells was studied . mRNA for perforin ( Pf ) , granzymes A and B , granulysin and Fas ligand ( FasL ) was simultaneously expressed in decidual gammadelta T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Macrophages from mice with mutations in either Fas or Fas ligand ( FasL ) demonstrated substantial resistance to FC induced apoptosis , and FC induced death in wild type macrophages was blocked by an anti FasL antibody . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Proinflammatory consequences of transgenic fas ligand expression in the heart . ^^^ Expression of Fas ligand ( FasL ) renders certain tissues immune privileged , but its expression in other tissues can result in severe neutrophil infiltration and tissue destruction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Among them , one is mediated by perforin and granzyme molecules , another is mediated by Fas ligand ( FasL ) which delivers apoptotic signals through Fas receptor on target cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tumor necrosis factor alpha ( TNF alpha ) , Fas ligand , and Bcl 2 , are measured with immunohistochemistry . ^^^ RESULTS : Chang hepatocytes grown in the coculture conditioned media have an increase in TNF alpha and Fas ligand . ^^^ The neuroblastoma cells have a significant decrease in Fas ligand . ^^^ CONCLUSIONS : Neuroblastoma cells grown in coculture conditioned media show increased expression of Bcl 2 and decreased Fas ligand levels . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Correlation of loss of CD 4 T cells with plasma levels of both soluble form Fas ( CD 95 ) Fas ligand ( FasL ) in HIV infected infants . ^^^ Fas and Fas ligand ( FasL ) , members of the TNFR and TNF families of molecules involved in apoptosis , respectively , are expressed in membrane associated as well as soluble forms . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression by LNCaP cells was enhanced by VES treatments . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : We have used this experimental model to sequentially analyze transcript levels of interferon gamma and interleukin ( IL ) 2 ( T helper 1 cytokines ) , IL 4 and IL 10 ( T helper 2 cytokines ) , RANTES , MIP1beta ( beta chemokines ) and their receptor CCR 5 , and Fas ligand ( cytolytic effector molecule ) . ^^^ In addition , RANTES ( after an early peak ) , MIP1beta , CCR 5 , and Fas ligand mRNA levels were suppressed in the fetal grafts compared with those in the adult grafts . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tumor cells from several organs including colon have recently been shown to express Fas ligand ( FasL ) in vitro and in vivo . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The counterattack hypothesis , suggesting that cancer cells express Fas ligand ( FasL ) and are able to kill Fas expressing tumor infiltrating activated T cells , was supported by reports of the killing of Jurkat cells by FasL expressing human colon cancer cell lines . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Bioactivities of Fas ligand expressing retroviral particles . ^^^ Culture supernatants from retroviral packaging cells carrying the human Fas ligand ( FasL ) gene killed both human ( Jurkat ) and mouse ( LB27 . 4 ) targets within 5 h of incubation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Moreover , evidence that the apoptotic programs were executed while Fas ligand mRNA expression was inhibited led us to analyze Bcl 2 dependent pathways . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We provide evidence in this study that Fas ligand ( FasL ) as well as Fas is present on muscle cells and inflammatory cells in myositis biopsies : Fas is present on most muscle cells and lymphocytes , and FasL is present on degenerating muscle cells and many infiltrating mononuclear cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Lipopolysaccharide and D galactosamine induced hepatic injury is mediated by TNF alpha and not by Fas ligand . ^^^ Tumor necrosis factor ( TNF ) alpha and Fas ligand ( FasL ) are trimeric proteins that induce apoptosis through similar caspase dependent pathways . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The paradoxical effects of Fas ligand . ^^^ Fas ligand ( FasL ) induces apoptosis of cells , including activated lymphocytes , expressing its cognate receptor , Fas ( CD95 / APO 1 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Propionibacterium acnes primed lipopolysaccharide ( LPS ) challenged liver injury is the prototype of IL 18 induced tissue injury , in which IL 18 acts on natural killer cells to increase Fas ligand ( FasL ) that causes liver injury by induction of Fas dependent hepatocyte apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Chronic neutropenia mediated by fas ligand . ^^^ Normal neutrophil survival is regulated by the Fas Fas ligand apoptotic system . ^^^ We hypothesized that neutropenia in LGL leukemia is mediated by dysregulated expression of Fas ligand . ^^^ Levels of Fas ligand in serum samples from patients with LGL leukemia were measured with a Fas ligand enzyme linked immunosorbent assay . ^^^ High levels of circulating Fas ligand were detected in 39 of 44 serum samples from patients with LGL leukemia . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
So , Fas and Fas ligand system is one candidate for apoptosis in the prostate glands , depending on removal of hormonal testosterone . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apart from the absence of Fas ligand immunoreactivity , the sharply reduced numbers of T cells and Langerhans cells , and the virtual absence of MHC class 1 expression all suggest that the anagen proximal hair follicle constitutes an area of immune privilege within the hair follicle immune system , whose collapse may be crucial for the pathogenesis of alopecia areata . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Inflammatory neutrophils underwent constitutive apoptosis in culture more rapidly than peripheral blood neutrophils ; this was not explained by changes in surface expression of Fas or by induction of Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand , or antibody to Fas , abrogated the T cell response , by inducing apoptosis of the APC stimulated T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas ( CD 95 ) / Fas ligand ( CD 95 ligand ) system functions in turning off immune responses by executing activation induced cell death ( AICD ) . ^^^ Elevation of soluble Fas and soluble Fas ligand in reactive macrophage activation syndromes . ^^^ Soluble Fas ( sFas ) and Fas ligand ( sFasL ) can interfere with their corresponding membrane bound counterparts , qualifying them as potential parameters of impaired immune termination . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Two cases of chronic graft versus host disease with elevated levels of soluble Fas ligand in serum . ^^^ It has recently been shown that the Fas Fas ligand ( FasL ) system may be one of the pathogeneses for acute graft versus host disease ( GVHD ) , and it has been reported that serum soluble Fas ligand ( sFasL ) increases with the presence of acute GVHD . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunohistochemical study on Fas and Fas ligand in skin wound healing . ^^^ An immunohistochemical study on the expression of Fas and Fas ligand ( Fas L ) was performed in order to examine the role of apoptosis through Fas Fas L in mouse skin wound healing . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Quantitation of Fas and Fas ligand gene expression in human ovarian , cervical and endometrial carcinomas using real time quantitative RT PCR . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Additionally , we associated the expressions of Fas , Fas ligand and caspase 3 in NSCLC to patient survival . ^^^ Corresponding results were obtained with the Fas ligand ( 87 vs 41 weeks ) and caspase 3 ( 87 vs 34 weeks ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis inducing ligands such as Fas ligand ( FasL ) and tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) have been found to play an important role in cell regulation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The aims of this study were to determine whether Sertoli cells can protect syngeneic islets from autoimmune destruction after transplantation into non obese diabetic ( NOD ) mice and , if so , whether protection is due to Sertoli cell expression of Fas ligand ( FasL ) , believed to be the mechanism that protects against allograft rejection . ^^^ Additionally , we examined the composition of the islet and Sertoli cell co transplants by immunohistochemistry to determine whether islet graft survival correlated with Sertoli cell expression of Fas ligand . ^^^ Immunohistochemical analysis of the islet and Sertoli cell co transplants showed a correlation between Fas ligand expression by Sertoli cells and graft infiltration by neutrophilic leucocytes , leading to islet beta cell destruction and diabetes recurrence . ^^^ CONCLUSION / INTERPRETATION : Sertoli cells exert opposing effects on survival of syngeneic islet grafts in nonobese diabetic mice : Fas ligand dependent neutrophil infiltration and graft destruction , and Fas ligand independent protection of the graft from autoimmune destruction . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Selective involvement of the Fas ( CD 95 ) / Fas ligand pathway in bone marrow B cell progenitors . ^^^ The Fas / Fas ligand ( FasL ) pathway has been implicated in apoptosis of various cell types . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL ) has been shown to induce apoptosis in cells expressing its receptor Fas . ^^^ We have recently shown that Fas ligand is overexpressed in all cases of Barrett ' s metaplasia ( BM ) with dysplasia and esophageal adenocarcinomas , and in a few cases of BM negative with dysplasia . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Endogenous interleukin 18 modulates immune escape of murine melanoma cells by regulating the expression of Fas ligand and reactive oxygen intermediates . ^^^ It has been known that melanoma cells can suppress the immune system by the Fas ligand . ^^^ The present study investigated whether interleukin ( IL ) 18 , which can enhance Fas ligand expression , is produced by B16F10 melanoma cells and is involved in immune escape of tumor cells . ^^^ The functional effect of IL 18 on B16F10 melanoma cells was shown by reduction of Fas ligand expression in cells treated with anti IL 18 antibody or transfected with IL 18 antisense cDNA . ^^^ In addition , the same treatments decreased intracellular reactive oxygen intermediate levels in B16F10 melanoma cells , indicating that IL 18 regulates reactive oxygen intermediate production , which is involved in Fas ligand expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Specific T cell deletion by transfected human monocytes expressing fas ligand and antigen . ^^^ Two mammalian expression vectors carrying the genes for human Fas ligand and a chimeric invariant chain tetanus toxin peptide construct were designed . ^^^ The T cell proliferative response to tetanus toxoid was inhibited when the antigen was presented by autologus monocytes transfected with Fas ligand . ^^^ T cell mixture experiments using two syngeneic T cell lines specific either for tetanus toxoid or for pertussis toxin demonstrated that the killing effect elicited by the antigen pulsed / Fas ligand transfected antigen presenting cells was antigen specific . ^^^ Antigen presenting cells transfected with the vector carrying Fas ligand and the vector carrying the chimeric invariant chain peptide antigen gene were shown to inhibit antigen specific T cell reactivity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , Fas resistant cells showed reduced expression of FADD , Fas ligand , and caspases 3 , 7 , and 8 and increased expression of FLIP and c IAP 1 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A non cleavable mutant of Fas ligand does not prevent neutrophilic destruction of islet transplants . ^^^ BACKGROUND : Fas ligand ( FasL ) mediates apoptosis of susceptible Fas expressing lymphocytes , and may contribute to the maintenance of peripheral tolerance . ^^^ Transplantation of ncFasL expressing islets under the kidney capsule of allogenic mice resulted in accelerated rejection identical to that seen with wild type Fas ligand expressing islets . ^^^ CONCLUSIONS : Membrane bound Fas ligand is fully capable of inducing a neutrophilic response to transplants , suggesting an activation by Fas ligand of neutrophil chemotactic factors . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RNA was extracted from BAL cell pellets and underwent competitive reverse transcription assisted polymerase chain reaction ( RT PCR ) for perforin , granzyme B , granulysin , and Fas ligand . ^^^ CONCLUSION : Quantification by competitive RT PCR of the CTL effector molecule transcripts ( perforin , granzyme B , granulysin , and Fas ligand ) could represent a valuable tool for the differential diagnosis of graft dysfunction in lung transplantation . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand transfected myoblasts and islet cell transplantation . ^^^ BACKGROUND : Expression of Fas ligand ( FasL , CD95L ) within the local environment of an allograft may protect from rejection by inducing apoptosis of infiltrating T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Adenovirus mediated transfer of p 53 and Fas ligand drastically enhances apoptosis in gliomas . ^^^ The recombinant adenoviruses ( Advs ) for p 53 and Fas ligand ( FL ) ( Adv p 53 and Adv FL , respectively ) were constructed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , MCF 7ADR cells possess a deletion mutation in p 53 and have considerably reduced levels of the Fas receptor , Fas ligand , caspase 2 , caspase 6 , and caspase 8 , suggesting that paclitaxel resistance may also stem from a bona fide block in paclitaxel induced apoptosis in these cells . ^^^ Morever , it appears that changes in the levels / activity of p 53 , the Fas receptor , Fas ligand , caspase 2 , caspase 6 , or caspase 8 activity have little effect on paclitaxel induced cytotoxicity and apoptosis in human breast cancer cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The inhibitory activity was neutralized by monoclonal antibody to Fas ligand . ^^^ CONCLUSION : These data suggest that soluble Fas ligand is a candidate suppressive factor in the aqueous humor . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand gene transfer prolongs rat renal allograft survival and down regulates anti apoptotic Bag 1 in parallel with enhanced Th 2 type cytokine expression . ^^^ BACKGROUND : Fas ligand ( FasL ) induces apoptosis of cells bearing Fas receptor , and may play a role in the acquisition of immune privilege . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand by human gastric adenocarcinomas : a potential mechanism of immune escape in stomach cancer . ^^^ Fas ligand ( FasL ) is a molecule that induces Fas receptor mediated apoptosis of activated immunocytes , thereby mediating normal immune downregulatory roles including immune response termination , tolerance acquisition , and immune privilege . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The NF kappa B signaling pathway is not required for Fas ligand gene induction but mediates protection from activation induced cell death . ^^^ The same stimuli also activate the gene encoding an apoptosis inducing molecule , Fas ligand ( FasL ) , which contributes to activation induced cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Neither Fas ligand nor endotoxin is responsible for inducible peritoneal phagocyte apoptosis during sepsis / peritonitis . ^^^ The aim of this study therefore was to determine if the increase in inducible phagocyte apoptosis and caspase activities seen in the peritoneum during sepsis is due to endotoxin or Fas ligand . ^^^ The inability to completely suppress these changes suggests that neither endotoxin ( via signaling through TLR 4 pathway ) nor Fas ligand regulates the peritoneal phagocyte apoptotic responses seen during the late phase of polymicrobial sepsis / peritonitis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We sought to investigate its mechanism of action and determine if it is Fas ligand ( FasL ) mediated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis mediated by the Apo 1 / Fas and Fas ligand pathways has been implicated in many disorders , including autoimmunity and tumorigenesis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This article reviews advances in the study of the molecular mechanisms for ultraviolet ( UV ) induced keratinocyte apoptosis , with particular reference to the cytokines tumor necrosis factor alpha ( TNF alpha ) and Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Lymphoma in Castleman ' s disease , acute lymphocytic leukemia , adult T cell leukemia and cutaneous T cell lymphoma accompanied with high serum soluble Fas ligand levels . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Detection of alternatively spliced variant messages of Fas gene and mutational screening of Fas and Fas ligand coding regions in peripheral blood mononuclear cells derived from silicosis patients . ^^^ Dysregulation of apoptosis , particularly in the Fas / Fas ligand ( FasL ) pathway , has been considered to play a role in the pathogenesis of autoimmune diseases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The immunomodulatory effect of blood transfusions and intravenous immunoglobulins : the role of the soluble molecules of the Class 1 major histocompatibility complex and of the Fas ligand ] . ^^^ We report that the concentrations of soluble major histocompatibility complex class 1 and soluble Fas ligand molecules are significantly higher in supernatants of blood components containing elevated numbers of residual donor leukocytes , such as red blood cells and random donor platelets , than in other blood components . ^^^ Elevated amounts of soluble Fas ligand molecules are also found in some intravenous immunoglobulin preparations . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis and apoptosis related proteins ( Fas , Fas ligand , bcl 2 , p 53 ) in macrophages of human ovarian epithelial tumors . ^^^ Apoptosis and the apoptosis related proteins ( ARP ) ( Fas , Fas ligand ( FasL ) , bcl 2 and p 53 ) were analyzed in macrophages of different human ovarian epithelial tumors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The lacrimal gland was then biopsied and the tissues stained with CD 3 , CD 4 , CD 8 , B 220 , APO2 . 7 , Fas , and Fas ligand ( Fas L ) antibodies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL ) is a member of the tumor necrosis family and when bound to its receptor , Fas , induces apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expressing mononuclear cells around intrahepatic bile ducts co express CD 68 in primary biliary cirrhosis . ^^^ In this study , we attempted to analyze Fas ligand ( FasL ) expressing mononuclear cells infiltrating in the portal tracts of PBC . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Resveratrol treatment had no effect on the expression of Fas receptor or Fas ligand ( FasL ) in THP 1 cells , nor did it induce clustering of Fas receptors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( CD 95 ) and Fas ligand ( FasL ) are an interacting receptor ligand pair that elicits apoptosis in many cell types . ^^^ Fas and Fas ligand interactions in malignant disease . ^^^ Fas ( CD 95 ) and Fas ligand ( FasL ) are an interacting receptor ligand pair that elicits apoptosis in many cell types . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Infection of C57BL / 6 mice but not of C3H / HeJ mice induced massive production of tumor necrosis factor alpha ( TNF alpha ) in serum , as well as an increase in Fas and Fas ligand ( FasL ) expression in T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These proteins are also known to interfere with programmed cell death induced by TNF alpha and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas antigen ( Fas ) is a cell surface receptor that induces apoptosis in sensitive cells when bound to Fas ligand or agonistic anti Fas monoclonal antibodies ( Fas mAb ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide inhibit T cell mediated cytotoxicity by inhibiting Fas ligand expression . ^^^ We reported recently that the neuropeptides vasoactive intestinal peptide ( VIP ) and pituitary adenylate cyclase activating polypeptide ( PACAP ) protect CD4+ T cells against Ag induced apoptosis by down regulating the expression of Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , whether alloreactive CD8+ T cells require traditional cytolytic pathways such as perforin and Fas ligand ( FasL ) to mediate graft rejection has been a controversial issue . ^^^ Results indicate that to reject established islet allografts , primed CD8+ T cells do not require the individual action of the conventional cytotoxic effectors perforin and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In additional studies , K 562 cells ( negative for beta 3 , TNF alpha , and Fas ligand ) transfected to express either alphavbeta 3 integrin , an uncleavable membrane form of TNF alpha , or both were used in cocultures with wound PMN . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( Apo 1 , CD 95 ) , a member of the nerve growth factor / tumour necrosis factor receptor superfamily , mediates apoptosis in response to agonistic antibodies or Fas ligand ( Fas L ) binding . ^^^ Fas and Fas ligand : strong co expression in human hepatocytes surrounding hepatocellular carcinoma ; can cancer induce suicide in peritumoural cells . ^^^ Fas ( Apo 1 , CD 95 ) , a member of the nerve growth factor / tumour necrosis factor receptor superfamily , mediates apoptosis in response to agonistic antibodies or Fas ligand ( Fas L ) binding . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Enhanced cell death in NR S 1 tumor by photodynamic therapy : possible involvement of Fas and Fas ligand system . ^^^ BACKGROUND AND OBJECTIVES : To investigate the effect of photodynamic therapy ( PDT ) on cell death in malignant tumor tissue , the frequency of terminal deoxynucleotidyl transferase mediated dUTP nick end labeling ( TUNEL ) positive cells and the possible involvement of Fas and Fas ligand system were evaluated . ^^^ Paraffin embedded tissue sections from the excised tumor tissues at 6 , 12 , 24 , 48 hours after PDT were analyzed by TUNEL for the occurrence of apoptosis and by immunohistochemistry for Fas and Fas ligand ( FasL ) expression . ^^^ The expression of Fas ligand was found in the tumor cells surrounding TUNEL positive cells on serial sections . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Proapoptotic Fas ligand is expressed by normal kidney tubular epithelium and injured glomeruli . ^^^ Fas ligand ( FasL ) is a cell membrane cytokine that can promote apoptosis through activation of Fas receptors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Differential roles of Fas ligand in spontaneous and actively induced autoimmune encephalomyelitis . ^^^ To determine the roles of Fas / Fas ligand ( FasL ) in autoimmunity , we studied spontaneous and actively induced autoimmune encephalomyelitis in 541 myelin basic protein specific T cell receptor transgenic mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Alloantigen driven T cell death mediated by Fas ligand and tumor necrosis factor alpha is not essential for the induction of allograft acceptance . ^^^ BACKGROUND : Fas ligand ( FasL ) Fas and tumor necrosis factor alpha ( TNFalpha ) tumor necrosis factor receptor ( TNFR ) interactions regulate immune responses and contribute to self tolerance by mediating antigen driven T cell apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Upregulation of the expression of Fas antigen and Fas ligand in a human submandibular gland ductal cell line by okadaic acid . ^^^ Binding of Fas ligand to the receptor leads to receptor activation and the induction of intracellular signals that result in apoptotic cell death . ^^^ In the present study , the expression of mRNA and proteins of Fas receptor and Fas ligand were examined in human submandibular gland ductal ( HSG ) cells treated with okadaic acid by reverse transcriptase polymerase chain reaction ( RT PCR ) and immunoblot analysis . ^^^ Fas ligand mRNA was also detected constitutively in HSG cells by RT PCR . ^^^ Okadaic acid stimulated the expression of Fas ligand protein in HSG cells in a time dependent manner , while the expression of the ligand was low in untreated HSG cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 4 T cells from either perforin deficient ( pfp 0 ) or Fas ligand ( FasL ) deficient ( gld ) mice exhibited a lower level of GVL activity but did not produce any long term survivors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tumor necrosis factor alpha ( TNF alpha ) or Fas Ligand activated apoptosis by binding of the plasma membrane receptor . ^^^ The activation of TNF Receptor 1 or Fas Ligand Receptor lead to activate of caspase 8 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Signaling through phosphorylation also regulates the expression of the Fas ligand ( FasL ) , the FasR , as well as various other proteins that affect the outcome of receptor stimulation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The levels of death promoting gene products such as the Fas receptor and the Fas ligand were upregulated in NK cells in the presence of anti class 1 and anti CD 16 antibodies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expressions of EBV encoded RNA and Fas ligand were detected in all cases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , the control of Fas and Fas ligand ( FasL ) expression in the testis remains unknown . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These results indicated that neither Fas ligand nor perforin are essential for Th 1 mediated liver injury in this model . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand mutations inhibit autoantibody production in pristane induced lupus . ^^^ Mutations of Fas ( lpr ) or Fas ligand ( gld ) cause a limited lupus like syndrome in B 6 mice by interfering with the deletion of autoreactive B and / or T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Subsequently , KCs undergo apoptosis induced by anti FasR mAb ' s , soluble Fas ligand , supernatants from activated T cells , or direct contact between T cells and KCs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A nonsecretory ligand mediated mechanism has been proposed for apoptosis and requires the interaction of Fas and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
IFN gamma , IL 2 , IL 10 , TNF beta , granulocyte macrophage colony stimulating factor and Fas ligand showed strong positive correlations with CD 3 delta , indicating an association between infiltrating T cells and these cytokines . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In our previous work , we have shown that CMA specifically inhibits perforin dependent cytotoxic T lymphocyte ( CTL ) mediated cytotoxicity through the degradation and inactivation of perforin , although CMA does not affect Fas ligand ( FasL ) dependent cytotoxicity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The results indicate that , despite surface expression of Fas receptor on Cou LB and Fas ligand induction on TC 5 and TC 7 cell membranes , the CD4+ cytotoxic T lymphocyte clones do not use this cytotoxic mechanism to lyse their specific target . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis in rat cardiac myocytes induced by Fas ligand : priming for Fas mediated apoptosis with doxorubicin . ^^^ Fas / Fas ligand ( FasL ) is well known for its role in delivering apoptotic signals ; however , it is unclear whether FasL can mediate apoptosis in cardiomyocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 4 T lymphocytes are primed to express Fas ligand by CD 4 cross linking and to contribute to CD 8 T cell apoptosis via Fas / FasL death signaling pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interestingly , CD 40 ligation was found to induce functional Fas ligand , TRAIL ( Apo 2L ) and TNF in apoptosis susceptible carcinoma cells and to up regulate expression of Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Adenoviral mediated delivery of FAS ligand to arthritic joints causes extensive apoptosis in the synovial lining . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : We previously reported that Fas antigen was strongly expressed on salivary duct epithelial cells and that some salivary infiltrating cells showed the Fas ligand in patients with severe sialoadenitis due to Sjgren ' s syndrome ( SS ) . ^^^ These findings suggest that the Fas Fas ligand system may play a role in the pathogenesis of sialoadenitis in SS . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand deficient mice display enhanced leukocyte infiltration and intima hyperplasia in flow restricted vessels . ^^^ Fas ligand ( FasL ) is a death factor that induces apoptosis in Fas bearing cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , there was an increased T cell chemoattractant activity after allergen challenge in patients with asthma ( p < 0 . 01 ) , which could be blocked by preincubation with anti IL 16 antibodies and which correlated significantly with the IL 16 protein levels ( R = 0 . 90 , p < 0 . 01 ) and with the level of Fas ligand expression on BAL CD 4 ( + ) cells ( R = 0 . 80 , p < 0 . 05 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( Fas L ) was present at the embryonic trophoectoderm . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas , Fas ligand , Bcl 2 , and Bax was assessed using immunohistochemistry . ^^^ Fas ligand expression was significantly less and Fas expression significantly greater in the villus trophoblast among the study subjects compared with controls . ^^^ CONCLUSION : Placental apoptosis and altered expression of Fas and Fas ligand in trophoblast might influence pathogenesis or sequelae of preeclampsia . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The value of renal allograft biopsy has been significantly enhanced by several developments : improved , internationally accepted classification of kidney transplantation pathology ( Banff 1997 ) and the development of molecular biological techniques such as RT PCR evaluation of perforin , granzyme B and Fas ligand , which can be applied to renal allograft tissue to obtain a diagnosis of acute rejection with high sensitivity and specificity , are very promising but not used in routine diagnosis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased accuracy of renal allograft rejection diagnosis using combined perforin , granzyme B , and Fas ligand fine needle aspiration immunocytology . ^^^ BACKGROUND : Two major routes by which cytotoxic T lymphocytes induce apoptosis in target cells are the perforin granzyme and the Fas ligand / Fas pathways . ^^^ METHODS : In this retrospective pilot study , 140 fine needle aspiration biopsy samples from 50 human renal allografts were labeled using alkaline phosphatase / anti alkaline phosphatase immunocytochemistry incorporating monoclonal antibodies to perforin , granzyme B , and Fas ligand . ^^^ CONCLUSIONS : In addition to providing valuable morphological information regarding the composition of inflammatory leukocyte populations and the preservation status of renal parenchymal cells , fine needle aspiration biopsy samples may be labeled using combined perforin , granzyme B , and Fas ligand immunocytochemistry to offer a safe and reliable method for diagnosing rejection with an excellent level of accuracy . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Through the use of perforin and Fas ligand ( FasL ) deficient mice , it was demonstrated that CD 4 ( + ) T cells mediate anti MMB3 . 19 effects in vivo primarily through the use of FasL and secondarily through perforin mechanisms . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas ( sFas ) blocks apoptosis induced by Fas ligand in vitro . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Changes of Fas and Fas ligand immunoreactivity after compression trauma to rat spinal cord . ^^^ This immunohistochemical study evaluated Fas and Fas ligand ( FasL ) in the rat nervous system and their changes in the spinal cord subjected to compression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The degree of apoptosis was analyzed in relation to several clinicopathologic parameters , cell proliferative activity , and immunohistochemical expression of apoptosis related proteins , including bcl 2 , bax , bcl 10 , bak , p 53 , p 21 ( WAF1 / CIP1 ) , Fas , and Fas ligand . ^^^ Many synovial sarcomas were diffusely positive for bcl 2 family proteins ( bcl 2 , bax , bcl 10 , and bak ) and were negative or only sporadically positive for Fas , Fas ligand , p 53 , and p 21 ( WAF1 / CIP1 ) proteins . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This NO induced macrophage apoptosis was inhibited by a Fas Fc chimeric molecule that binds to Fas ligand ( FasL ) and prevents its interaction with endogenous cell surface Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Several members of this family , such as the lymphotoxins ( LT alpha and LT beta ) , Fas ligand , and TNF , induce cell death in some normal and transformed cells , but also induce cell growth and differentiation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
C57BL / 6 and BALB / c T cells can lyse Renca cells through the use of both granule and Fas ligand ( FasL ) mediated pathways . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand is expressed in normal breast epithelial cells and is frequently up regulated in breast cancer . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We have therefore studied the kinetics of putative modulators and mediators of IL 2 induced immune activation , namely IL 1beta , IL 4 , IL 5 , IL 10 , IL 12 , soluble Fas ligand ( sFasL ) , and GM CSF during IL 2 therapy . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These effects were paralleled by the induction of the G 1 cyclins D 3 and E and by the inhibition of induction of the proapoptotic Fas , Fas ligand , and BAD genes in starved cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Bcl 2 inhibits calcineurin mediated Fas ligand expression in antitumor drug treated baby hamster kidney cells . ^^^ We report here that an increase of Fas and Fas ligand ( FasL ) expression was required for antitumor drug induced apoptosis in WI 38 and baby hamster kidney ( BHK ) cells , but not in HL 60 cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of the inflammatory chemokine monocyte chemotactic protein 1 , apoptosis effector genes Fas and Fas ligand , and oxidative stress gene HO 1 was evaluated by reverse transcriptase polymerase chain reaction . ^^^ Similarly , Fas and Fas ligand expression were increased in control UUO kidneys compared with sham operated ones ( P < 0 . 05 ) . ^^^ The induction of Fas ligand was attenuated in all treatment groups ( P < 0 . 05 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To this purpose , we used immunohistochemistry to analyze HIF 1 alpha and HIF 1 beta in formalin fixed , paraffin embedded , non small cell lung carcinomas ( n = 96 ) and compared the HIF expression with cyclin A protein expression , cell cycle phases , the apoptotic index and the expression of caspase 3 , Fas and Fas ligand . ^^^ However , a significant correlation between HIF 1 expression , apoptosis and the pro apoptotic factors caspase 3 , Fas , and Fas ligand could be detected . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We analysed the release of cytokines , CD 95 ( Apo 1 / Fas ) and CD 95 L ( Fas Ligand ) of human blood cells after exposure to ionizing radiation in vitro and in vivo by ELISA technique . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas Fas ligand pathway does not actively work in extrahepatic bile duct carcinoma . ^^^ Fas and Fas ligand expression were immunohistochemically investigated in 34 extrahepatic bile duct carcinomas ( BDC ) and nine ampulla carcinomas ( AC ) . ^^^ Fas ligand expression in infiltrating mononuclear cells adjacent to the carcinoma nests was observed in only four BDC ( 11 . 1 % ) and in none of the AC examined . ^^^ Fas ligand expression in carcinoma cells was observed in only one BDC , which showed Fas ligand expression also in mononuclear cells and not in any AC case . ^^^ These results suggest that , although BDC and AC very frequently express Fas , Fas mediated apoptosis is only occasionally induced in carcinoma cells because of the lack of Fas ligand expression in infiltrating mononuclear cells in these carcinomas . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It was found that activated T cells rapidly acquire the expression of both Fas and Fas ligand ( FasL ) on their surface and contain high levels of the precursor form of the pro apoptotic enzyme , caspase 8 ( FLICE ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We then quantified the serum soluble Fas ligand ( sFasL ) , which was known to bind to Fas and induce the apoptotic signals into the sensitized cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In perforin / B 6 mice and B 6 gld / gld ( Fas ligand ) mice , NK cells were found to mediate cytotoxicity through perforin while NKT cells mediated self reactive cytotoxicity through Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , DP and CD 4 ( + ) SP tumor populations displayed higher levels of Fas ligand than normal thymocytes with the same phenotypes . ^^^ In contrast , CD 8 ( + ) SP and CD 4 ( ) CD 8 ( ) tumors did not show elevated Fas ligand expression . ^^^ There was no significant correlation between Fas and Fas ligand expression in the DP tumors , suggesting that Fas Ligand expression was not the driving force behind Fas down regulation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Restricted expression of an adenoviral vector encoding Fas ligand ( CD95L ) enhances safety for cancer gene therapy . ^^^ Gene transfer of Fas ligand ( CD95L ) using adenoviral vectors has been shown to generate apoptotic responses and potent inflammatory reactions that can be used to induce the regression of malignancies in vivo , but these vectors also cause significant hepatotoxicity that may limit their clinical utility . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
There are many other molecules , including Fas ligand and cytokines such as interferon gamma , interleukin 1 and tumor necrosis factor alpha , which may lead to beta cell destruction either directly or indirectly via regulation of toxic molecules such as nitric oxide . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble form of fas and fas ligand in BAL fluid from patients with pulmonary fibrosis and bronchiolitis obliterans organizing pneumonia . ^^^ STUDY OBJECTIVES : The Fas Fas ligand ( FasL ) pathway is a representative system of apoptosis signaling receptor molecules . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cisplatin induced apoptotic cell death in mouse hybrid neurons is blocked by antioxidants through suppression of cisplatin mediated accumulation of p 53 but not of Fas / Fas ligand . ^^^ Accumulation of p 53 , Fas , and Fas ligand ( Fas L ) was also demonstrated in these neurons . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Clinical significance of simultaneous determination of serum soluble transferrin receptor , soluble Fas , soluble Fas ligand , hepatocyte growth factor and interleukin 18 levels in a patient with hemophagocytic syndrome . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Using combinations of monoclonal antibodies we were able to show that TNF alpha / effector lymphocytes exhibit both perforin and Fas ligand based cytotoxicity . ^^^ Furthermore , upon in vivo administration of rTNF alpha these effectors , in addition to perforin and Fas ligand , are also armed with TNF alpha cytotoxic molecules , thus resembling to the cytotoxic effectors from control mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Co incubation with beta chemokines did not inhibit anti CD 3 induced expression of cell surface Fas ligand , nor did it alter levels of the death receptor Fas or Bcl 2 in T cell blasts , suggesting that the beta chemokines are blocking AICD downstream of Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , expression of apoptosis regulating proteins Bcl 10 , Fas and Fas Ligand was studied by immunohistochemistry . ^^^ Expression of Bcl 10 , Fas and Fas Ligand was equal at all ages . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Intrathecal administration of neutralizing antibody against Fas ligand suppresses the progression of experimental autoimmune encephalomyelitis . ^^^ A therapy aimed at blocking the Fas / Fas ligand ( FasL ) system was investigated using a relapsing form of experimental autoimmune encephalomyelitis ( EAE ) in mice , an animal model of multiple sclerosis ( MS ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The mRNA expression of the cytokines IFN gamma , IL 10 and TNF alpha and the proapoptotic factor Fas ligand ( FasL ) was compared in freshly isolated CD 4 ( + ) and CD 8 ( + ) tumour infiltrating lymphocytes ( TIL ) and simultaneously obtained autologous CD 4 ( + ) and CD 8 ( + ) peripheral blood lymphocytes ( PBL ) from 20 patients with renal cell carcinomas ( RCC ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , TGF beta treatment of BL 41 cells was found not to affect the cell surface expression of Fas , TNF R 1 , DR 3 , DR 4 , or DR 5 , or the steady state expression levels of Fas ligand , TNF R 1 , DR 3 , DR 4 , and DR 5 . ^^^ Furthermore , blocking experiments indicated that TGF beta mediated apoptosis is not dependent on Fas ligand , TNF alpha , tumor necrosis like apoptosis inducing ligand , or TNF like weak inducer of apoptosis signaling . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Members of the TNF superfamily , including Fas , Fas ligand , and CD 40 , have been shown to be expressed on tumor cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A variety of malignancies express Fas ligand ( FasL ) , which can induce apoptosis in effector lymphocytes and may limit the success of cellular immunotherapy . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand expression in fetal and adult human testis with normal or deranged spermatogenesis . ^^^ In mice , the Fas / Fas ligand ( FasL ) system has been shown to be involved in germ cell apoptosis . ^^^ In the present study we evaluated the expression of Fas and Fas ligand ( FasL ) in fetal and adult human testis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : Serum levels of TNF alpha , soluble TNF receptor 1 and 2 , soluble Fas antigen , and Fas ligand were measured . ^^^ Soluble Fas and soluble Fas ligand levels tended to increase in all types of acute liver disease and were not specific to fulminant hepatitis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We studied the expression of Fas antigen on liver tissues , Fas ligand in lymphocytes , and soluble Fas ligand in patients ' serum . ^^^ Simultaneously , Fas ligand presenting on both liver infiltrated cells and peripheral lymphocytes was studied by reverse transcription polymerase chain reaction , and soluble Fas ligand in sera was measured by ELISA . ^^^ In addition , Fas ligand on both liver infiltrating lymphocytes and peripheral lymphocytes in fulminant hepatic failure patients was detected . ^^^ The serum level of soluble Fas ligand was significantly increased in fulminant hepatic failure ( mean value , 2 . 91 ng / ml in fulminant hepatic failure [ n = 10 ] , 1 . 62 ng / ml in acute hepatitis [ n = 10 ] , and 0 . 27 ng / ml in healthy controls [ n = 10 ] ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A comparative study of Fas and Fas ligand expression during melanoma progression . ^^^ Fas receptor ( APO 1 / CD95 ) binding to its ligand , Fas ligand ( Fas L ) , has been shown to trigger apoptosis in various cell types . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : Fas ( CD 95 ; APO 1 ) is a transmembrane protein that mediates apoptosis upon cross linking with Fas ligand ( Fas L ) . ^^^ Expression of Fas and Fas ligand in primary cutaneous T cell lymphoma ( CTCL ) : association between lack of Fas expression and aggressive types of CTCL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Several death receptors and ligands , Fas and Fas ligand being the most important to date , are expressed in the skin and have proven to be essential in contributing to its functional integrity . ^^^ Likewise , induction of death signaling by ultraviolet light can lead to hapten specific tolerance , and gene transfer of Fas ligand to dendritic cells can be used to induce antigen specific tolerance by deleting antigen specific T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Selective upregulation of fibroblast Fas ligand expression , and prolongation of Fas / Fas ligand mediated skin allograft survival , by retinoic acid : the skin as a retinoide inducible immune privilege site . ^^^ Fas / Fas ligand mediated lymphocyte apoptosis has been implicated in the suppression of immune responses and may cause immune privilege . ^^^ Human corneas exhibit immune privilege and can be transplanted across allogeneic barriers without immunosuppressive therapy , perhaps , because corneal keratinocytes express Fas ligand . ^^^ To characterize Fas and Fas ligand expression in skin , we examined expression by murine keratinocytes , dermal fibroblasts , melanocytes , and human umbilical endothelial cells . ^^^ We also studied the regulation of Fas and Fas ligand in skin cells by retinoic acid , vitamin D 3 , and dexamethasone as well as various cytokines . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of CPP 32 , Fas and Fas ligand and the relationship between their expression and viral antigens in chronic hepatitis ] . ^^^ OBJECTIVE : To study the significance of Fas Fas ligand ( FasL ) CPP 32 mediated hepatocytic apoptosis and the relationship between their expression and hepatitis C virus ( HCV ) antigens in pathogenesis of chronic hepatitis C ( CHC ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) and Fas ligand ( FasL ) have been implicated in the pathogenesis of graft versus host disease ( GVHD ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of wild type and noncleavable Fas ligand by tetracycline regulated adenoviral vectors to limit intimal hyperplasia in vascular lesions . ^^^ Previous studies have shown that Fas ligand ( FasL ) gene transfer to balloon injured vessels inhibits lesion formation by killing both proliferating VSMCs and infiltrating inflammatory cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Role of serum soluble Fas / soluble Fas ligand and TNF alpha on response to interferon alpha therapy in chronic hepatitis C . ^^^ AIMS / BACKGROUND : To determine the relationship between host factors and host response to interferon ( IFN ) therapy , serum soluble Fas ( sFas ) , soluble Fas ligand ( sFas ligand ) , and tumor necrosis factor alpha ( TNF alpha ) were analyzed in 41 patients with chronic hepatitis C ( CH C ) treated with IFN alpha . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In these pure lymphocyte preparations the mRNA expression of IL 1 , IL 10 , IFN gamma , TNF alpha , Fas and Fas ligand was determined by using a semiquantitative RT PCR . ^^^ RESULTS : The CD 3 ( + ) TIL from 21 patients with PCa and 20 patients with BPH expressed significantly higher levels of IL 10 and Fas ligand mRNA compared to the autologous CD 3 ( + ) PBL , whereas the expression of IL 1 , TNF alpha and Fas mRNA was not different in either cell population . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the present study , the effect of cPrG * HCl on a promyelocytic leukemia cell line ( HL 60 ) was examined . cPrG * HCl lowered intracellular pH and induced apoptosis through up regulation of Fas ligand , activation of stress activated protein kinase ( SAPK / JNK ) and caspase . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand and Bax gene transcription contributes to Ro 60 ribonucleoprotein redistribution in UV A irradiated human keratinocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The control of oocyte apoptosis is not fully understood , although survival factors ( LIF , kit ligand and FGF ) , as well as death inducing factors ( fas ligand , TGFbeta ) , have been identified . ^^^ Fas ligand binding on oocytic fas may result in caspase 8 activation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
FADD ( also known as MORT 1 ) is an essential adapter protein that couples the transmembrane receptors Fas ( CD 95 ) and tumor necrosis factor receptor 1 ( TNF R 1 ) to intracellular cysteine proteases known as caspases , which propagate and execute the programmed cell death inducing signal triggered by Fas ligand ( FasL , CD95L ) and TNF . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Both Fas ( APO 1 , CD 95 ) , an apoptosis inducing receptor , and its ligand , Fas ligand ( FasL , CD95L ) , have been localized to the ovary . ^^^ Immunolocalization of Fas and Fas ligand in the ovaries of women with polycystic ovary syndrome : relationship to apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Reverse transcription polymerase chain reaction ( RT PCR ) analysis identified the upregulation of Fas ligand ( FasL ) and granzyme B mRNAs within the infected retinas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Examination of genetically matched tumor cell lines that possessed either wild type or null p 53 loci indicated that cells possessing functional p 53 increased their surface levels of Fas and Fas ligand ( FasL ) in response to DNA damage . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Using NFAT 1 mutant proteins that are unable to interact with Fos Jun dimers but are unaffected in DNA binding or transcriptional activity , we show that expression of interleukin ( IL ) 2 , granulocyte macrophage colony stimulating factor ( GM CSF ) , IL 3 , IL 4 , MIP1alpha and Fas ligand mRNAs is absolutely dependent on cooperation between NFAT and Fos Jun ; in contrast , NFAT induces tumor necrosis factor alpha ( TNFalpha ) mRNA and IL 13 promoter activity without any necessity to recruit Fos and Jun . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , we examined whether captopril blocks activation induced apoptosis by interfering with expression of Fas , Fas ligand ( FasL ) , or both on T cell hybridomas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : Recent studies indicate that soluble Fas ( sFas ) may modulate T cell apoptosis , since it inhibits Fas ligand ( Fas L ) mediated cytotoxicity in vitro . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunohistochemistry was performed to detect expression of both fas and fas ligand ( fasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A targeted DNA vaccine encoding fas ligand defines its dual role in the regulation of experimental autoimmune encephalomyelitis . ^^^ This study used naked DNA vaccination to induce breakdown of tolerance to self and thus elicit immunological memory to native , membrane bound Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble HLA class 1 and Fas ligand molecules in blood components and their role in the immunomodulatory effects of blood transfusions . ^^^ In the present paper we report that the concentrations of soluble HLA class 1 ( sHLA 1 ) and soluble Fas ligand ( sFasL ) molecules in supernatants of blood components which contain elevated numbers of residual donor leukocytes , like red blood cells and random donor platelets , are significantly higher than in other blood components . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
All cases except ATLL expressed the cytotoxicity associated molecule of TIA 1 , and 11 of 14 TIA 1 positive cases expressed activated cytotoxic molecules of perforin , granzyme B , and / or Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Caspase 3 activity , Bcl 2 ( protein ) , and Fas ligand ( mRNA ) were assayed in pancreas extracts and alpha amylase in plasma . ^^^ Fas ligand mRNA was increased only in alcohol fed , LPS injected rats . ^^^ These data show that ( a ) long term alcohol feeding suppresses apoptosis in the pancreas ; ( b ) LPS increases the rate of apoptosis in the pancreas ; ( c ) caspase 3 activity and Bcl 2 expression change in opposite directions ; ( d ) TUNEL positivity and Fas ligand expression are increased , and Bcl 2 is decreased in ethanol fed + LPS injected rats . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The molecules of the two major cytotoxic pathways , Fas ligand ( FasL ) and perforin , were expressed by Tc 1 , Tc 2 , and Th 1 cells , whereas Th 2 cells expressed only FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Reactive astrocytes upregulate Fas ( CD 95 ) and Fas ligand ( CD95L ) expression but do not undergo programmed cell death during the course of anterograde degeneration . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It was previously shown that reactive astrocytes express high levels of Fas ( CD 95 ) and respond to Fas ligand ( CD95L ) by apoptosis or IL 8 production . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CGP57148B treatment down regulated antiapoptotic XIAP , cIAP 1 , and Bcl 10 ( L ) , without affecting Bcl 2 , Bax , Apaf 1 , Fas ( CD 95 ) , Fas ligand , Abl , and Bcr Abl levels . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas Fas ligand system in silicosis patients ] . ^^^ On the other hand , details about the relationship between autoimmunity and defective functioning of the Fas Fas ligand system have been analyzed . ^^^ In this report , we intend to summarize our results which suggest a suppressed apoptosis through the Fas Fas ligand system in silicosis patients , and to speculate on the effects of silica on inappropriate cell survival which could induce the development of autoimmune reactions . ^^^ We observed elevated levels of serum sFas and an increased expression of sFas mRNA in silicosis patients . sFas instead of membranous Fas binds competitively to the Fas ligand , and consequently , reduces the apoptosis of Fas positive cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Functional expression of Fas and Fas ligand on human colonic intraepithelial T lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptotic death of astrocytes is mainly mediated by Fas ligand released in supernatants of HIV infected M / M ( as demonstrated by complete reversal of such phenomenon by adding neutralizing antibodies against CD 95 receptor ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL ) cDNA transformants were cytotoxic against osteoblasts , and the cytotoxicity was increased when osteoblasts were treated with TNF alpha . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although Fas and Fas ligand were expressed on T 84 cells and PMNLs , treatment of epithelial cells with an antagonistic anti Fas antibody failed to prevent apoptosis induced by migrating PMNLs . ^^^ This apoptotic process appears to involve remodeling of the actin cytoskeleton of enterocytes independent of the Fas / Fas ligand pathway . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TNF family including TNF alpha , TNF beta , Fas ligand ( FasL ) and TNF related apoptosis inducing ligand ( TRAIL ) were suggested to be important for AILb A induced killing activity of PBMC by reverse transcription polymerase chain reaction ( RT PCR ) analysis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas ligand levels in ALS sera were not different from those in normal sera , except for slightly higher levels in a single case . ^^^ In mixed cultures of rat embryonic brain and spinal cord cells , ALS sera ( and agonistic anti Fas monoclonal antibodies and soluble Fas ligand ) induced the apoptosis of a subpopulation of neurons . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Inhibitors of HMG CoA reductase sensitize human smooth muscle cells to Fas ligand and cytokine induced cell death . ^^^ This stability may be greatly influenced by pro inflammatory mediators such as IFN gamma , TNF alpha , and Il 1beta and Fas ligand ( FasL ) that are present in human atheroma . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Killing of Fas ligand resistant renal carcioma cells by interleukin 2 and BCG activated effector cells . ^^^ Perforin and Fas ligand ( FasL ) have been described as the major lytic principles in cellular cytotoxicity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The local release of sFas by AML blasts may then function as a protective mechanism by competing with membrane bound Fas for binding sites on the common Fas ligand ( FasL ) . sFas was released by AML blasts during in vitro culture , and this release was modulated by several cytokines that can be secreted by activated T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Moreover , Fas ligand ( FasL ) expression was detected on the cell surface as well as the cytoplasm of colorectal cancer cells in 61 % of cases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Perforin and Fas ligand ( FasL ) are the major cytolytic molecules of cytotoxic lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
At each time point , histologic sections were treated with the direct fluorescein labelled TUNEL method and immunostained for pancreatic hormones ( glucagon , insulin ) , apoptotic promoters ( Bak , Bax , Fas , Fas Ligand ) as well as for the anti apoptotic peptide Bcl 2 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Sorting out the multiple roles of Fas ligand . ^^^ Fas ligand can both be used by the immune system to initiate cell death , and be used by non lymphoid cells to evade death . ^^^ Recent work has shown that Fas ligand is differentially sorted in different cell types . ^^^ Here we present the viewpoint that the differential sorting plays an important part in determining the role of Fas ligand in different cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TNF alpha , Fas ligand or cellular stress . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Because CD 437 induced the expression of DR 4 , DR 5 and Fas , we examined the effects of combining CD 437 and tumor necrosis factor ( TNF ) related apoptosis inducing ligand ( TRAIL ) and Fas ligand , respectively , in HPC cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Among the expressions of 21 different genes observed in allografts at 1 , 14 , 30 , or 60 days after retransplantation , those of T cell activation related genes , such as interferon y and Fas ligand , showed the earliest and the most dramatic difference between 3 and 5 day retransplanted allografts whereas macrophage / monocyte activation related genes showed little difference . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Up regulation of fas ligand at early stages and down regulation of Fas at progressed stages of intrahepatic cholangiocarcinoma reflect evasion from immune surveillance . ^^^ We examined immunohistochemically the possible participation of the Fas / Fas ligand ( FasL ) system in intrahepatic cholangiocarcinoma ( ICC ) during the escape from immune surveillance , using 68 cases of ICC , 29 cases of normal intrahepatic large bile ducts , and 18 cases of biliary dysplasia . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas ligand and soluble Fas in ocular fluid of patients with uveitis . ^^^ AIMS : To investigate the presence of soluble Fas ligand ( sFasL ) and soluble Fas ( sFas ) in ocular fluid of patients with uveitis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis , proliferation , and Fas ( APO 1 , CD 95 ) / Fas ligand expression in medullary carcinoma of the breast . ^^^ This study evaluates the extent of apoptosis in relation to Fas ( APO 1 , CD 95 ) / Fas ligand ( FasL ) expression in MC . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Suppression of Fas expression and down regulation of Fas ligand in highly aggressive human thyroid carcinoma . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas and soluble Fas ligand in children with Escherichia coli O 157 : H 7 associated hemolytic uremic syndrome . ^^^ We measured soluble Fas ligand ( sFas L ) and soluble Fas ( sFas ) levels by sandwich enzyme linked immunosorbeny assay and compared them among ( 1 ) healthy controls ( n = 11 ) , ( 2 ) children with hemorrhagic colitis ( HC ) caused by a non verotoxin producing pathogen ( n = 23 ) , ( 3 ) patients with uncomplicated Escherichia coli O 157 : H 7 HC ( n = 14 ) , and ( 4 ) children with O 157 : H 7 associated hemolytic uremic syndrome ( HUS ) ( n = 24 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
High glucose also inhibited apoptosis induced by Fas ligand ( 100 ng / mL ) ( normal 23+ / 2 % , high D glucose 13+ / 2 % ; P : < 0 . 006 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the two cases where tissue was available for immunohistochemical study in frozen sections , neoplastic cells showed CD 56 ( Leu 19 ) + perforin+ Fas ligand ( FasL ) + CD 2 ( Leu5b ) CD 3 ( Leu 4 ) CD 4 ( Leu 3 ) CD 5 ( Leu 1 ) CD 7 ( Leu 9 ) CD 8 ( Leu 2 ) betaF 1 TCRdelta 1 phenotypes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand expression were detected by immunofluorescence and flow cytometry and soluble ligand by enzyme linked immunosorbent assay ( ELISA ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These families may include receptor / ligand molecules such as Fas , Fas ligand , tumor necrosis factor receptor 1 ( TNFR 1 ) , and TNF related apoptosis inducing ligand ( TRAIL ) ; signal transduction adapter molecules such as Fas associated death domain ( FADD ) , TNFR 1 associated death domain ( TRADD ) , receptor interacting protein ( RIP ) , Fas associated factor ( FAF ) , and Fas associated phosphatase ( FAP ) ; or effector molecules such as caspases . ^^^ To detect the expression of apoptosis related molecules , ribonuclease protection assay was used with specific antisense RNA probes for Fas , Fas ligand , TNFR 1 , TRAIL , FADD , TRADD , RIP , FAF , FAP , and caspase 8 . ^^^ Immunostaining for Fas , Fas ligand , TRAIL , TRADD , RIP , and caspase 8 was also performed . ^^^ Compared with control and contralateral kidneys , the ligated kidneys displayed a dynamic expression of mRNAs for many apoptosis related molecules , which included an up to threefold increase for Fas , Fas ligand , TNF R 1 , TRAIL , TRADD , RIP , and caspase 8 , and an up to twofold increase for FADD and FAP , but there was little change for FAF . ^^^ We demonstrated a positive immunostaining for Fas and Fas ligand in the tubular cells at early time points as well as in interstitial inflammatory cells at later time points . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Intracellular Fas ligand expression causes Fas mediated apoptosis in human prostate cancer cells resistant to monoclonal antibody induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To analyze immune requirements , we immunized gene knockout ( KO ) mice of C57BL / 6 background , deficient in either CD 3 , CD 4 , CD 8 , interferon gamma ( IFNgamma ) , perforin or Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of core protein did not alter the cell surface expression of Fas , indicating that the increased sensitivity of core expressing cells to Fas ligand was not due to upregulation of Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The early transcription unit E 3 of Ads encodes proteins that inhibit antigen presentation by MHC class 1 molecules as well as apoptosis induced by tumor necrosis factor alpha ( TNF alpha ) and Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The role of Fas Fas ligand was explored using Fas ligand targeted mutant ( generalized lymphoproliferative disease ) mice . ^^^ Intrapancreatic interleukin 12 , interferon gamma , Fas ligand , and CD 40 ligand messenger RNA were detected by reverse transcription polymerase chain reaction . ^^^ T lymphocyte transfer into nude mice partially restores the severity of acute pancreatitis and intrapancreatic interferon gamma , interleukin 12 , and Fas ligand gene transcription . ^^^ The severity of pancreatitis is also reduced by in vivo CD 4 ( + ) ( but not CD 8 ( + ) ) T cell depletion and in Fas ligand targeted mutant mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Blocking of Fas ligand ( FasL ) reduced apoptosis by 50 % and simultaneous blocking of FasL and TNF receptors by 70 % . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Our results have demonstrated that TILs have three different gene expression profiles : the first set of genes is involved in cell proliferation and mitogenic stimulation , such as c myc and IL 8 , LD 78 , MIP 1beta , insulin induced protein and AH receptor ; the second set of genes includes those involved in attachment of lymphocytes to endothelium and extravasation into tumor tissues such as P selectin ligand and integrin ; and the third set , which includes genes such as the perforin , FAS ligand and granzyme B , is related to cytotoxic function to tumor cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVE : Cytotoxic T lymphocytes ( CTL ) initially recognize target cells using the T cell receptor ( TCR ) , then strongly adhere to these cells by accessory molecules , and finally induce apoptosis by Fas ligand ( FasL ) / Fas or lyse by the granzyme / perforin system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas and Fas ligand reflects the biological characteristics but not the status of apoptosis of intrahepatic cholangiocellular carcinoma . ^^^ We therefore decided to investigate the status of apoptosis and of Fas and Fas ligand expression in this carcinoma . ^^^ We performed immunohistochemistry for Fas and Fas ligand in 40 CCC cases and evaluated the apoptotic index ( AI ) by counting the number of morphologically apoptotic cells per 1000 cells . ^^^ Fas ligand expression in the stromal infiltrating mononuclear cells did not correlate with any clinicopathological features of CCC , but was directly related to Fas expression in CCC cells . ^^^ Fas ligand was also expressed in CCC cells in 27 . 5 % of the cases and more frequently observed in cases with moderate or poor differentiation and high Ki 67 LI . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Lymphocytes were isolated and examined for quantification and phenotypic analysis of apoptosis using the 7 amino actinomycin D method , as well as for Fas and Fas ligand , interleukin 1 converting enzyme p20 / caspase 1 , Bcl 2 , and p 35 expression . ^^^ RESULTS : Twenty four hours after surgery , CD 4 ( + ) and CD 8 ( + ) cells exhibited a significantly higher frequency of apoptosis as well as of Fas and Fas ligand and interleukin 1 converting enzyme p20 / caspase 1 expressions than preoperatively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To clarify the roles of these various regulators in granulocyte survival , we have investigated the spontaneous apoptosis of granulocytes in culture and that induced by Fas ligand or chemotherapeutic drugs , using cells from normal , CD 95 deficient lpr , or vav bcl 2 transgenic mice . ^^^ CD 95 induced apoptosis , which required receptor aggregation by recombinant Fas ligand or the membrane bound ligand , was unaffected by G CSF treatment or Bcl 2 overexpression . ^^^ Fas ligand , Bcl 2 , granulocyte colony stimulating factor , and p 38 mitogen activated protein kinase : Regulators of distinct cell death and survival pathways in granulocytes . ^^^ CD 95 induced apoptosis , which required receptor aggregation by recombinant Fas ligand or the membrane bound ligand , was unaffected by G CSF treatment or Bcl 2 overexpression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Contrasting with our previous report using cultured splenic DCs , freshly isolated splenic DCs killed YAC 1 cells using a Ca ( 2+ ) independent mechanism , but this function did not appear mediated by Fas ligand , TNF related apoptosis inducing ligand , or TNF alpha . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this study we found that in mice lacking the IgM transmembrane tail exons ( muMT mice ) , in which B cell development is blocked at the pro B stage , the absence of Fas or Fas ligand allows significant B cell development and maturation , resulting in high serum Ig levels . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This process was preceded by up regulation of Fas ( CD 95 ) and Fas ligand expression in response to IL 12 plus IL 18 and was blocked by zVAD , a large spectrum caspase inhibitor , as well as by anti Fas ligand mAb , suggesting the involvement of the Fas pathway . ^^^ Fas / Fas ligand interactions promote activation induced cell death of NK T lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Decreased neutrophil adhesion to human cytomegalovirus infected retinal pigment epithelial cells is mediated by virus induced up regulation of Fas ligand independent of neutrophil apoptosis . ^^^ Reduced neutrophil adhesion to infected RPE cells correlated with HCMV induced up regulation of constitutive Fas ligand ( FasL ) expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of the adenovirus serotype 5 ( Ad 5 ) E1A oncogene sensitizes cells to apoptosis by TNF alpha and Fas ligand . ^^^ Because TNF related apoptosis inducing ligand ( TRAIL ) kills cells in a similar manner as TNF alpha and Fas ligand , we asked whether E1A expression might sensitize cells to lysis by TRAIL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We find that a full strength primary response depends on beta ( 2 ) microglobulin ( class 1 major histocompatibility complex [ MHC ] and class 2 MHC and on IFN gamma and interleukin 6 ( IL 6 ) but not on TAP 1 , perforin , IL 4 , Fas ligand , or inducible nitric oxide synthetase . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand gene polymorphisms in primary Sjgren ' s syndrome . ^^^ OBJECTIVE : To screen for polymorphisms in the apoptosis regulating Fas and Fas ligand ( FasL ) genes in patients with primary Sjgren ' s syndrome ( SS ) , and to explore associations with susceptibility to the disease . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Glucocorticoid and Fas ligand induced mucosal lymphocyte apoptosis after burn injury . ^^^ BACKGROUND : The purpose of this study was to examine the effects of a steam burn injury on apoptosis in gut associated lymphoid tissue and to determine whether endogenous glucocorticoid and Fas ligand signaling were involved in this process . ^^^ Similarly , C3H / HeJ FasL ( gld ) mice lacking functional Fas ligand were also studied . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Serum soluble Fas ( CD 95 ) and Fas ligand profiles in chronic kidney failure . ^^^ The Fas / Fas ligand ( FasL ) system is a key regulatory apoptotic pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand mediated mechanisms are involved in autoimmune destruction of islet beta cells in non obese diabetic mice . ^^^ AIMS / HYPOTHESIS : A mechanism implicated in pancreatic islet beta cell destruction in autoimmune diabetes is the binding of the Fas ligand ( FasL ) on T cells to Fas receptors on beta cells , causing their destruction . ^^^ The aim of this study was to find whether the Fas ligand contributes to beta cell death in autoimmune diabetes . ^^^ METHODS : We transplanted syngeneic islets under the renal capsule in non obese diabetic ( NOD ) mice and treated the mice with a neutralizing monoclonal antibody to the Fas ligand . ^^^ RESULTS : We found 58 % ( 7 of 12 ) of mice treated with anti Fas ligand antibody were normoglycaemic at 30 days after islet transplantation compared with none ( 0 of 9 ) of the mice treated with control antibody . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Perforin ( PF ) , Fas ligand ( FasL ) and TNF alpha are considered to be important factors in cytotoxic T lymphocyte mediated cell injury , and several studies have established a role of lymphotoxin ( LT ) in T helper type 1 ( Th 1 ) induced cell mediated autoimmune diseases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Moreover , Fas ligand levels were increased within the testes of rats that were chronically fed ethanol . ^^^ In vitro , ethanol treatment of cultured Sertoli cells enhanced the production of Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recipients deficient in both perforin and Fas ligand but not individually were highly susceptible to DLI GVHD . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the large granular lymphoma line YT , CD 30 signals down regulate the expression of cytotoxic effector molecules , Fas ligand , perforin , granzyme B , and abrogate cytotoxicity . c myc , a regulator of proliferation and an upstream regulator of Fas ligand expression , is completely suppressed by CD 30 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A ' non canonical ' DNA binding element mediates the response of the Fas ligand promoter to c Myc . ^^^ Although the mechanism of c Myc induced apoptosis remains unclear , it is susceptible to regulation by survival factors [ 2 , 3 ] and can proceed through the interaction of Fas ligand ( FasL ) with its receptor , Fas [ 4 ] . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Adenovirus mediated transfer of Fas ligand gene augments radiation induced apoptosis in U 373MG glioma cells . ^^^ Thus , transduction of Fas ligand would selectively kill malignant astrocytoma cells . ^^^ To override the resistance mechanism of glioma cells with p 53 mutation to radiation , we transduced U 373MG malignant astrocytoma ( glioma ) cells harboring mutant p 53 with Fas ligand via an adenovirus ( Adv ) vector in combination with 10 ray irradiation , and evaluated the degree of apoptosis . ^^^ The degree of apoptosis in U 373MG cells infected with the Adv for Fas ligand ( Adv FL ) and treated with irradiation ( 81 % ) was much higher than that in U 373MG cells infected with Adv FL and not treated with irradiation ( 0 . 8 % ) or that in U 373MG cells infected with the control Adv for lacZ and treated with irradiation ( 5 . 0 % ) . ^^^ In U 373MG cells infected with Adv FL , irradiation increased the expression of Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of perforin and Fas ligand mRNA in the liver of viral hepatitis . ^^^ We studied the expression of mRNAs of perforin and Fas ligand ( Fas L ) in biopsy specimens from chronic hepatitis B ( CHB ) ( 15 cases ) and hepatitis C ( CHC ) patients ( 13 cases ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Role of nonspecific cytotoxic cells in the induction of programmed cell death of pathogenic protozoans : participation of the Fas ligand Fas receptor system . ^^^ In the present study these pathogenic protozoans were developed as a model system to describe the potential role of the Fas ligand ( FasL ) Fas receptor ( FasR ) system as a means of innate immunity in teleosts . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression coincides with alveolar cell apoptosis in late gestation fetal lung development . ^^^ We determined the spatiotemporal patterns of the cell death regulators Fas and Fas ligand ( FasL ) during rabbit lung development and correlated their expression with pulmonary and type 2 cell apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Subtypes of SMC expressing abundant levels of Sp 1 produce the death agonist , Fas ligand ( FasL ) and undergo greater spontaneous apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Our previous studies have shown that bovine granulosa cells cultured in basal media supplemented with 5 % fetal bovine serum ( BM FBS ) are resistant to apoptosis induced by recombinant Fas ligand ( FasL ) unless pretreated with interferon gamma ( IFN ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL ) was not detected by RNase protection assay , but RT PCR revealed a significant increase in FasL expression 4 h after the repair of torsion . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression and apoptosis in primary rat hepatocytes induced by lipopolysaccharide . ^^^ After 24h or 48 h of LPS treatment at various concentrations ( 1 , 5 , 10 mug / ml ) , membrane bound Fas ligand ( mFasL ) expression in hepatocytes was determined by immunocytochemistry , and apoptosis was detected by TUNEL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To elucidate the different role of NFkappaB in chemotherapy induced apoptosis , we investigated the expression of Fas ( CD 95 ) and Fas ligand ( CD 95 ligand ) , which have been described as important mediators of chemotherapy induced cell death and as target genes of NFkappaB . ^^^ However , our investigations demonstrated that in hepatoma cells , the chemotherapy induced up regulation of Fas ( CD 95 ) and Fas ligand ( CD 95 ligand ) is not transcriptionally mediated through NFkappaB . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CM 101 infusion led to elevated levels of Fas protein within the tumors as well as a decrease in the expression of fas ligand ( fasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Induction of apoptosis in MGMT cells was not triggered by Fas and Fas ligand ( CD 95 , Apo 1 ) because both proteins remained unaltered in expression and receptor proximal caspase 8 was not activated after methylation . ^^^ Overall , the data indicate that O6MeG induces apoptosis via secondary lesions that trigger Bcl 2 decline , cytochrome c release , and caspase 9 and caspase 3 activation independently of Fas / Fas ligand and p 53 , for which the cells are mutated . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The CD 95 ( APO 1 / Fas ) Fas ligand ( FasL ) system is an important mediator of antitumor T cell cytotoxicity . ^^^ Expression of Fas and Fas ligand and apoptosis in tumor associated lymphocytes and in tumor cells from malignant pleural effusions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis induced in T cells by human neuroblastoma cells : role of Fas ligand . ^^^ The CD95 / CD95L ( Fas / Fas ligand ) receptor / ligand system plays an important role in regulation of cell survival and induction of a programmed cell death . ^^^ T cell death was reduced after treatment of NB cells ( in vitro ) with antibody to FAS ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand expressed on cells of the immune system , not on the target tissue , control induction of experimental autoimmune uveitis . ^^^ The Fas Fas ligand ( FasL ) interaction is important for maintaining lymphocyte homeostasis by signaling for activation induced cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Bioactive Fas ligand ( FasL ) expressing vesicles were generated ( vesicle preparation , VP ) from two cell lines overexpressing FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand costimulates the in vivo proliferation of CD8+ T cells . ^^^ Fas ligand ( FasL / CD95L / APO 1L ) is one of a growing number of TNF family members whose triggering costimulates maximal proliferation of activated T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TRAIL , but not TNF alpha or Fas ligand , was shown to induce marked changes in MMP in melanoma , which showed a high correlation with TRAIL induced apoptosis . ^^^ In addition , TRAIL , but not TNF alpha or Fas ligand , was shown to induce clustering of mitochondria around the nucleus . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Regulation of fas ligand expression in breast cancer cells by estrogen : functional differences between estradiol and tamoxifen . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Improvement of extrathymic T cell type of large granular lymphocyte ( LGL ) leukemia by cyclosporin A : the serum level of Fas ligand is a marker of LGL leukemia activity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RNA was reverse transcribed and amplified with specific primers for Fas and Fas ligand and analyzed on agarose gels . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The aim of this study was to determine whether Fas ligand ( FasL ) and / or transforming growth factor ( TGF ) beta , immunoregulatory proteins produced by Sertoli cells , might mediate the protective effects of these cells against autoimmune destruction of islet beta cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The concentration of soluble Fas ligand in activated T cell culture supernatants was actually increased by EHDP . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of fas ligand on bile ductule epithelium in biliary atresia a poor prognostic factor . ^^^ PURPOSE : The aim of this study was to investigate the possible role of Fas and Fas ligand system in biliary atresia . ^^^ METHODS : Immunohistochemical stains of Fas and Fas ligand ( FasL ) and in situ hybridization of Fas ligand messenger RNA ( mRNA ) were performed on paraffin embedded liver specimens of 36 biliary atresia , 6 choledochal cysts , and 14 nontumorous parts of pediatric liver tumors . ^^^ CONCLUSIONS : Fas ligand expression on bile ductule epithelia in biliary atresia may be induced to counterattack the infiltrating lymphocytes . ^^^ Although the factors for post Kasai bile drainage are multiple , the authors suggest Fas ligand expression on bile ductule epithelia may be a poor prognostic factor by playing a role in the continuous damage and obliteration of intrahepatic bile ducts after Kasai operation . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Roles of Fas and Fas ligand during mammary gland remodeling . ^^^ In this study , we evaluated the expression of Fas and Fas ligand ( FasL ) in the mammary gland tissue and their possible role in the induction of apoptosis of mammary cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Treatment of human leukemic cells with etoposide , Ara C , or doxorubicin increased DR 5 but not DR 4 , Fas , DcR 1 , DcR 2 , Fas ligand , or Apo 2L levels . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , mice carrying a null function mutation in the Fas ligand , which is involved in an alternative cytotoxic mechanism , developed clinical disease and histologic lesions which were comparable to those in wild type mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Death associated protein kinase ( DAP Kinase ) is a serine / threonine kinase with a death domain that is involved in apoptosis induced by interferon gamma , TNF alpha , and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis was potentiated by Fas Ligand ( APO 1L , CD95L ) , a pro apoptotic peptide , only in LNZ 308 cells , corresponding to the known functional Fas expression in these cell lines . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
After concanamycin A treatment to specifically evaluate Fas dependent cytotoxicity , LAK cells expressing Fas ligand killed only Fas positive cells , but not Fas negative cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Amplification and expression of a decoy receptor for fas ligand ( DcR 3 ) in virus ( EBV or HTLV 1 ) associated lymphomas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of Fas and Fas ligand ( FasL ) mRNA in thyroids was also determined by RT PCR in both CD 8 ( + ) and CD 8 depleted recipient mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The sensitivity of these cells to an agonistic anti Fas receptor antibody ( CH 11 ) and the effects of an antagonistic anti Fas ligand antibody ( 4H9 ) on Ad5CMV p 53 induced apoptosis were analyzed by the MTT assay and DNA fragmentation assay . ^^^ RESULTS : Ad5CMV p 53 treatment resulted in substantial growth inhibition , induction of apoptosis and up regulation of Fas receptor as well as Fas ligand mRNA expression in LNCaP , DU 145 and PC 3 cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Induction of Fas expression and augmentation of Fas / Fas ligand mediated apoptosis by the synthetic retinoid CD 437 in human lung cancer cells . ^^^ In the present study , we investigated whether CD 437 induced the expression of Fas ( CD95 / APO 1 ) , a cell surface protein belonging to the tumor necrosis factor receptor superfamily , which induces apoptosis upon interaction with Fas ligand ( FasL ) or agonistic antibodies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Intracellular Fas ligand in normal and malignant breast epithelium does not induce apoptosis in Fas sensitive cells . ^^^ Fas ligand ( FasL ) is expressed on some cancers and may play a role in the immune evasion of the tumour . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Serum levels of soluble Fas ( sFas ) and soluble Fas ligand ( sFasL ) were significantly higher in the myocarditis group than in the 2 control groups . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas engagement induces the maturation of dendritic cells ( DCs ) , the release of interleukin ( IL ) 1beta , and the production of interferon gamma in the absence of IL 12 during DC T cell cognate interaction : a new role for Fas ligand in inflammatory responses . ^^^ Engagement of Fas on immature DCs by Fas ligand ( FasL ) or by anti Fas antibodies induces the phenotypical and functional maturation of primary DCs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , antibodies to Fas ligand blocked cytotoxic activity , suggesting that some of the antitumor cytotoxicity was Fas ligand mediated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Loss of Fas ligand expression in mouse keratinocytes during UV carcinogenesis . ^^^ Skin cells containing excessive ultraviolet ( UV ) radiation induced DNA damage are eliminated by apoptosis that involves the p 53 pathway and Fas / Fas Ligand ( Fas L ) interactions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Jun NH 2 terminal kinase activation leads to a FADD dependent but Fas ligand independent cell death in Jurkat T cells . ^^^ Similar to that reported previously , Fas ligand ( FasL ) expression was up regulated by JNK activation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The T lymphocytes also expressed Fas ligand , suggesting the involvement of Fas mediated cytotoxicity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
All three HNSCC cell lines examined expressed Fas protein but not Fas ligand mRNA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Peripheral blood for FACS immunophenotyping , isolation of peripheral mononuclear cells ( PMNC ) , and serum ELISA assays for IL 12 and soluble Fas ligand ( sFasL ) was collected daily during the first 4 post operative weeks . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
First , these cells displayed a high rate of spontaneous apoptosis on culture in cytokine free medium and were also sensitive to Fas mediated apoptosis induced by soluble Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand gene transfer combined with low dose cyclosporine A reduces acute lung allograft rejection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The membrane Fas ligand expression was significantly increased in hippocampal sympathetic ingrowth and in cholinergic denervation compared to the control group . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : Apoptosis in Jurkat cells was induced by Fas ligand ( Fas L ) , and the fate of autoantigenic P proteins was analysed in both normal and apoptotic total cell extracts . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Human pancreatic cancer cells express non functional Fas receptors and counterattack lymphocytes by expressing Fas ligand ; a potential mechanism for immune escape . ^^^ The aim of this study was to investigate the expression and functional status of Fas ligand ( FasL ) and its receptor ( Fas ) in human pancreatic cancers . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CONCLUSIONS : Our study strongly indicates that IL 18 together with IL 12 induces intestinal mucosal inflammation in an IFN gamma dependent but TNF alpha , NO , and Fas ligand independent manner , and fatty liver is dependent on IFN gamma and NO . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunohistochemical analysis revealed that this synergistic killing effect was dependent on apoptotic cell death with upregulation of both Fas and FasL ( Fas ligand ) expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This study investigated the dynamics of splenic and granuloma CD 4 ( + ) Th cell apoptosis and Fas ligand ( FasL ) expression during the acute and chronic stages of murine schistosomal infection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Some well known membrane molecules involved in the activation of apoptotic pathways ( e . g . , TNF related apoptosis inducing ligand , Fas ligand , TNF alpha ) were ruled out as candidate effectors for the suppression mechanism . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Silicon phthalocyanine 4 photodynamic therapy also resulted in a time dependent increase in ( 1 ) the multimerization of Fas protein , ( 2 ) the protein expression of Fas ligand , ( 3 ) FADD , an adapter molecule for Fas , and ( 4 ) the binding of FADD with Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
When human Jurkat , or its transformants , expressing mouse Fas were treated with Fas ligand or anti mouse Fas antibodies , the cells died , showing characteristics of apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Western blots were used to determine expression of the components involved in the initiation ( Fas , Fas Ligand , FADD ) , regulation ( Bcl 2 , Bax ) and execution ( caspase 2 and caspase 3 ) of apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CONCLUSIONS : This pattern supports the hypothesis that a defect in T cell apoptosis may play a part in the pathophysiology of CTCL , perhaps through abnormalities of the Fas / Fas ligand system . ^^^ Alternatively , this decrease could be the result of the presence of the soluble Fas ligand molecule in the sera of patients with CTCL . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fe accumulation , secondary to mitochondrial or nuclear DNA mutations ) or is secondary to an extracellular stimulus [ e . g . tumour necrosis factor ( TNF ) , Fas ligand ( FasL ) ] remains to be determined . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cellular markers associated with apoptosis Fas , Fas ligand ( FasL ) , Bcl 2 , and Bax were examined by immunohistochemistry . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Prognostic significance of Fas and Fas ligand system associated apoptosis in gastric cancer . ^^^ BACKGROUND : Previous studies indicate that gastric carcinomas express Fas ligand and down regulate Fas to escape from the host immune attack ; however , the prognostic importance of Fas / FasL expression in this tumor is yet to be evaluated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Canine interleukin 18 induces apoptosis and enhances Fas ligand mRNA expression in a canine carcinoma cell line . ^^^ To investigate Fas ligand ( FasL ) expression on the cell line , we cloned the partial sequence of canine Fas Ligand ( FasL ) cDNA from canine lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Of the investigated pro apoptotic factors ( Fas / CD95 , Fas ligand , caspase 3 ) , only Fas / CD95 is significantly associated with the drug response ( P = 0 . 007 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , the expression of Fas ligand ( FasL ) in NOD mice by infiltrating lymphocytes was suppressed with 0 . 1 % CyA eye drops . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Circulating soluble Fas ligand in patients with gastric carcinoma . ^^^ BACKGROUND : The Fas / Fas ligand ( FasL ) system is involved in cancer cell death induced by the immune system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The DCs injected produced interferon alpha and expressed Fas ligand mRNA but did not exhibit cytolytic activity in vitro . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Freshly isolated NK cells , but not natural killer T cells or ordinary T cells , from the liver expressed cell surface TRAIL , which was responsible for spontaneous cytotoxicity against TRAIL sensitive tumor cells in vitro along with perforin and Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Serum Fas and Fas ligand were measured by ELISA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The loss of T cell function was associated with an increased frequency of circulating monocytes , their expression of Fas ligand ( FasL ) and a high frequency of apoptotic CD4+ T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of inducible nitric oxide synthase and Fas / Fas ligand correlates with the incidence of apoptotic cell death in atheromatous plaques of human coronary arteries . ^^^ Fas and Fas ligand were expressed in almost same areas that iNOS was expressed . ^^^ By double label immunostaining , Fas was expressed in T lymphocytes but Fas ligand was expressed in macrophages and in some T lymphocytes . ^^^ These results suggest that NO from iNOS induces Fas and Fas ligand mediated apoptosis and associates with regression of atherosclerosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To date , many reports have implicated a role for the cell death inducing ligand pair Fas and Fas ligand ( FasL ) . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tissue infiltrating CD4+ T cells purified from the salivary glands of a mouse model for SS bear a large proportion of Fas ligand and the salivary gland duct cells possess apoptotic receptor Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Both GRKO and 129Sv / J allografts evoked vigorous host immune responses including alloantibody and mRNA for cytotoxic T cell genes ( perforin , granzyme B , Fas ligand ) , and displayed similar expression of complement inhibitors ( CD 46 , CD 55 , CD 59 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cyclosporin A ( CsA ) nephropathy is associated with altered expression of apoptosis regulatory genes such as Fas ligand and Bcl 2 family members in the glomerular , tubulointerstitial , and vascular compartments . ^^^ We investigated whether Bcl xL and Fas / Fas ligand were regulated by CsA in cultured podocytes and whether CsA induced apoptosis was prevented by HGF or IGF 1 . ^^^ Apoptosis was quantitated by ELISA and by flow cytometry ; Bcl xL , Fas , and Fas ligand were measured by Western blotting . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Promising therapeutic effects have been obtained in animal models of restenosis or vein graft thickening with the transfer of genes coding for VEGF , nitric oxide synthase , thymidine kinase , retinoblastoma , growth arrest homoeobox , tissue inhibitor of metalloproteinases , cyclin or cyclin dependent kinase inhibitors , fas ligand and hirudin , and antisense oligonucleotides against transcription factors or cell cycle regulatory proteins . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide inhibit expression of Fas ligand in activated T lymphocytes by regulating c Myc , NF kappa B , NF AT , and early growth factors 2 / 3 . ^^^ Activation induced cell death in T cells , a major mechanism for limiting an ongoing immune response , is initiated by Ag reengagement and mediated through Fas / Fas ligand interactions . ^^^ We reported previously that VIP / PACAP protect T cells from activation induced cell death through down regulation of Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although these cells display near normal levels of perforin and Fas ligand , they remain largely at a naive state as judged by high expression of CD 62 ligand and failure to up regulate activation or memory markers . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Complete regression of established spontaneous mammary carcinoma and the therapeutic prevention of genetically programmed neoplastic transition by IL 12 / pulse IL 2 : induction of local T cell infiltration , Fas / Fas ligand gene expression , and mammary epithelial apoptosis . ^^^ In juvenile mice , early administration of IL 12 / pulse IL 2 markedly limits the expected genetically programmed neoplastic transition within the mammary epithelium and does so in conjunction with enhancement of constitutive Fas and pronounced induction of local Fas ligand gene expression , T cell infiltration , and induction of apoptosis within the mammary epithelium . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expanded Valpha 24 ( + ) Vbeta 11 ( + ) T cells expressed the cytotoxic molecule granzyme B , showed negligible expression of Fas ligand and could be induced to express high levels of interferon gamma , while retaining the capacity to produce IL 4 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL ) expression of RPE cells is generally recognized to be essential for the immune privilege of the eye , but due to contradictory published results , it is unclear whether RPE cells express this molecule . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This tumor induced T cell death is mediated by the activities of caspase 8 and caspase 3 and is partially inhibited by antibodies to either Fas or Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The role of Fas Fas ligand mediated apoptosis in autoimmune lacrimal gland disease in MRL / MpJ mice . ^^^ METHODS : Inflammatory cells in the lacrimal glands of MRL / lpr and MRL / + mice were evaluated for apoptosis with TUNEL staining and Fas and Fas ligand expression with immunohistochemistry . ^^^ Fas ligand expression was present on epithelial structures in both substrains . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Neutrophils induce apoptosis of lung epithelial cells via release of soluble Fas ligand . ^^^ Neutrophils release soluble Fas ligand ( sFasL ) , which can induce apoptosis in certain Fas bearing cell types ( Liles WC , Kiener PA , Ledbetter JA , Aruffo A , and Klebanoff SJ . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
While cytotoxic T lymphocyte antigen 4 ( CTLA 4 ) negatively regulates T cell receptor ( TCR ) driven interleukin ( IL ) 2 production and proliferation , little is known regarding whether the coreceptor has the capacity to inhibit other events , such as Fas ligand ( FasL ) expression and antigen induced cell death ( AICD ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Functional studies demonstrated that 1 ) concanamycin A , a selective inhibitor of perforin / granzyme B based cytolysis , blocked DC stimulated NK cytotoxicity against K 562 cells ; and 2 ) neutralizing mAb against Fas ligand ( FasL ) significantly reduced DC stimulated NK cytotoxicity against Fas positive Jurkat cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas was progressively downregulated after successive in vitro restimulations of antigen specific CD 8 cells , until clones became Fas negative and totally resistant to the effects of recombinant Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Apo 1 ( CD 95 ) mediated apoptosis of neutrophils with Fas ligand ( CD95L ) expressing tumors is crucial for induction of inflammation by neutrophilic polymorphonuclear leukocytes associated with antitumor immunity . ^^^ Fas / Apo 1 ( CD 95 ) mediated apoptosis of neutrophils with Fas ligand ( CD95L ) expressing tumors is crucial for induction of inflammation by neutrophilic polymorphonuclear leukocytes associated with antitumor immunity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble HLA class I / CD8 ligation triggers apoptosis in EBV specific CD8+ cytotoxic T lymphocytes by Fas / Fas ligand interaction . ^^^ Apoptosis is triggered by the interaction of Fas ( + ) CTL with soluble Fas ligand , which is released following the binding of sHLA 1 antigens to CD 8 molecules . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas ligand ( Fas L ) expressed on mature erythroblasts may induce apoptosis of more immature erythroid cells that express Fas , whereas stem cell factor ( SCF ) may prevent Fas mediated cell death in hematopoietic progenitor cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
No major changes in the serum levels of soluble Fas and soluble Fas ligand were found throughout the course . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
During inflammatory reactions in the central nervous system ( CNS ) , resident macrophages , the microglia , are exposed to Th 1 cell derived cytokines and pro apoptotic Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Fas ligand mediated death pathway is involved in oxLDL induced apoptosis in vascular smooth muscle cells . ^^^ In the present study , we demonstrate that the expression of death mediators , including p 53 , Fas , and Fas ligand ( FasL ) was substantially upregulated by oxLDL in cultured vascular smooth muscle cells ( SMCs ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( CD 95 ) Fas ligand interactions are responsible for monocyte apoptosis occurring as a result of phagocytosis and killing of Staphylococcus aureus . ^^^ Fas ( CD 95 ) Fas ligand interactions are responsible for monocyte apoptosis occurring as a result of phagocytosis and killing of Staphylococcus aureus . ^^^ Cells exposed to bacteria were examined for the surface expression of Fas and Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Hepatoma cells were inoculated subcutaneously into 6 week old rats , and 4 months later the quantities of T and B cells , macrophages , and cells positive for Fas , Fas ligand ( FasL ) and interleukin 2 ( IL 2 ) were immunochemically evaluated in tumors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Plasma soluble Fas ligand concentration : decrease in elderly men and increase in patients with gastric carcinoma . ^^^ Fas ligand ( FasL ) , which induces apoptosis against Fas expressing cells , has been found to be expressed on various cell types including cancer cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cellular expressions and serum concentrations of Fas ligand and Fas receptor in patients with infectious mononucleosis . ^^^ Accumulated evidence has revealed that the apoptosis mediating system , Fas receptor / Fas ligand ( Fas R / Fas L ) , plays an important role in this disease . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased apoptosis of B CLL cells is not associated with modifications in the expression of Bcl 2 , Fas or Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas transduces apoptotic signals upon cross linking with the Fas ligand ( FasL ) , which is experimentally replaced by agonistic anti Fas monoclonal antibodies ( mAb ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Circulating levels of soluble Fas ligand and soluble Fas in patients with chronic obstructive pulmonary disease . ^^^ Since patients with chronic obstructive pulmonary disease ( COPD ) show chronic hypoxaemia and the activation of the TNF alpha system , we investigated whether these pathophysiological changes influence the Fas Fas ligand system . ^^^ We measured the circulating soluble Fas ligand ( sFas L ) level , an inducer of apoptosis , and the soluble Fas receptor ( sFas ) level , an inhibitor of apoptosis , in 34 COPD patients and 35 age matched healthy controls . ^^^ These results suggest that the Fas Fas ligand system does not independently play an important role in the pathophysiology of patients with COPD . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Stromelysin 1 ( MMP 3 ) in synovial fluid of patients with rheumatoid arthritis has potential to cleave membrane bound Fas ligand . ^^^ OBJECTIVE : To investigate the relationship between matrix metalloproteinases ( MMP ) and the soluble form of Fas ligand ( sFasL ) in the synovial fluid ( SF ) of patients with rheumatoid arthritis ( RA ) , and to determine which MMP have a major role in cleaving FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Our previous results showed that rheumatoid synoviocytes expressed Fas ligand and were induced apoptosis by anti Fas antibody treatment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Paraffin embedded tissue sections were stained with specific monoclonal antibodies to Fas , Fas ligand ( FasL ) , caspase 3 , and bax . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Malaria infection induces rapid elevation of the soluble Fas ligand level in serum and subsequent T lymphocytopenia : possible factors responsible for the differences in susceptibility of two species of Macaca monkeys to Plasmodium coatneyi infection . ^^^ Furthermore , soluble Fas ligand levels in sera of the infected Japanese macaques increased gradually to a markedly high level of 28 . 83 + / 10 . 56 pg / ml ( n = 4 ) when the animals became moribund . ^^^ On the other hand , none of the infected cynomolgus monkeys exhibited either T lymphocytopenia or elevated soluble Fas ligand level . ^^^ Both Fas and Fas ligand expression were increased in the spleen . ^^^ Increased levels of soluble Fas ligand in serum in Plasmodium falciparum malaria . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas / Fas ligand by decidual leukocytes in hydatidiform mole . ^^^ Fas ligand ( FasL ) expression by placental trophoblast may induce apoptosis of Fas+ lymphocytes , thereby facilitating immune tolerance and survival of the molar trophoblast . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas and Fas ligand in normal and ischemia reperfusion testes : involvement of the Fas system in the induction of germ cell apoptosis in the damaged mouse testis . ^^^ The aim of this study was to examine the possible involvement of the Fas and Fas ligand ( FasL ) system in the induction of germ cell apoptosis in normal and ischemia reperfusion testes of adult mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cutting edge : the class 2 transactivator prevents activation induced cell death by inhibiting Fas ligand gene expression . ^^^ The Fas : Fas ligand pathway is critical in regulating immune homeostasis by eliminating activated T cells that proliferated in response to an infection . ^^^ Here , we show that the MHC class 2 transactivator ( CIITA ) can suppress this pathway by inhibiting transcription of the Fas ligand gene . ^^^ CIITA can effectively repress transcription from the Fas ligand promoter in both T cell lines as well as primary cells . ^^^ The repression appears to be at least partly due to interference of NFAT mediated induction of Fas ligand gene transcription . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand is expressed on liver infiltrating cells , pointing to death by fratricide that causes almost complete disappearance of virus specific CTL 4 wk after infection . ^^^ CTL elimination is virus dose dependent , and high doses induced high alanine aminotransferase values , elevated expression of Fas ligand on CD 8 cells , and increased CD 8 cell migration into the infected liver . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Fas ligand pathway , apoptosis , and clonal anergy involved in systemic acetylcholine receptor T cell epitope tolerance . ^^^ A high dose of alpha 146 162 peptide in IFA failed to suppress T cell proliferation and / or clinical myasthenia gravis in lpr and gld mice deficient in Fas and Fas ligand , respectively . ^^^ The findings implicate the possible role of Fas / Fas ligand mediated apoptosis and the resulting clonal anergy as the mechanisms of high dose AChR alpha 146 162 peptide induced tolerance on CD 4 cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this study , we examined whether cis diaminedichloroplatinum ( 2 ) cisplatin ( CDDP ) sensitizes MART 1 / HLA A2 . 1 ( + ) melanoma and melanoma variant tumor cells to non MHC restricted , Fas ligand ( FasL ) mediated killing by CTL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The present study sought to characterize the expression of Fas , Fas ligand ( FasL ) , and Fas associated death domain like interleukin 1beta converting enzyme inhibitory protein ( FLIP ) , and to quantify the apoptosis induced by agonistic anti Fas antibody , using mononuclear cells ( MNC ) isolated from the peripheral blood ( PB ) and synovial fluid ( SF ) of RA patients . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Matrix metalloproteinase 7 mediated cleavage of Fas ligand protects tumor cells from chemotherapeutic drug cytotoxicity . ^^^ Recent evidence suggests that one mechanism whereby cytotoxic drugs , such as doxorubicin , kill tumors is the induction or up regulation of Fas ligand ( FasL ) expression on the tumor cell surface . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Treatment with paclitaxel or taxotere increased DR 4 and / or DR 5 protein levels ( up to 8 fold ) without affecting the protein levels of DcR 1 and DcR 2 , Apo 2L / TRAIL , Fas , or Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
FAS / FAS ligand interaction at the placental interface is not required for the success of allogeneic pregnancy in anti paternal MHC preimmunized mice . ^^^ PROBLEM : FAS ligand ( FASL ) induces apoptosis in FAS+ T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand ( Fas L ) were immunohistochemically detectable on macrophages and fibroblasts in skin wound healing process . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast to TNF alpha or Fas ligand , relatively little is known about the signaling events activated by TRAIL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand is an early event in colorectal carcinogenesis . ^^^ BACKGROUND AND OBJECTIVES : Fas ligand ( FasL ) is expressed in many cancers and plays an important role in establishing immunologically privileged environments that allow tumors to escape the host ' s immune surveillance . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression in Hodgkin lymphoma . ^^^ Because previous investigations suggested involvement of the Fas ligand ( FasL ) in the selection process in the follicular dendritic cell ( FDC ) associated cell cluster of the germinal center , we investigated the expression of FasL in Hodgkin lymphoma ( HL ) on protein and RNA level , while considering the Epstein Barr virus status of the Hodgkin and Reed Sternberg ( HRS ) cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activation induced apoptosis was assessed by DNA fragmentation and the expression of Fas / CD95 receptor and Fas ligand ( Fas L ) was measured by flow cytometry . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A short peptide derived from the antisense homology box of Fas ligand induces apoptosis in anti Fas antibody insensitive human ovarian cancer cells . ^^^ We found that a short synthetic peptide corresponding to the `` antisense homology box ' ' of Fas ligand induced apoptotic cell death of Fas expressing human ovarian cancer cell lines . ^^^ The peptide was deduced from residues 256 265 of human Fas ligand , based on the hypothesis that it should contain a specific binding site to the corresponding Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Culture of monocytes with AGE beta ( 2 ) m did not alter membrane expression of Fas or Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Insights into the Fas ligand enigma . ^^^ Fas ligand ( FasL ) has become an enigmatic molecule : some evidence indicates that it contributes to immune privilege in tissues and tumors , whereas other data demonstrates that FasL can elicit inflammation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Hypoxia stimulates release of the soluble form of fas ligand that inhibits endothelial cell apoptosis . ^^^ Fas ligand ( FasL ) , an apoptosis inducing cytokine , is constitutively expressed on endothelial cells ( EC ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Elevated levels of soluble Fas and Fas ligand in cerebrospinal fluid of patients with AIDS dementia complex . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Messenger RNA and protein of Bcl xS and Fas ligand , known as proapoptotic factors , were both reduced after coarctation ( P < . 005 vs controls ) . ^^^ These changes were associated with upregulation of TGF beta and downregulation of Bcl xS and Fas ligand gene expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , in sharp contrast to PBC , none of the inflammatory cells infiltrating into the bile ducts in BA expressed cytotoxic markers such as perforin , granzyme B , or Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( Apo 1 / CD95 ) is a cell surface receptor involved in cell death signaling through binding of Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand and apoptosis of disc cells in herniated lumbar disc tissue . ^^^ OBJECTIVE : To investigate the cell type that expresses Fas ligand ( FasL ) and any evidence of apoptosis of the disc cells in herniated lumbar disc tissues . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The testis is the main source of Fas ligand ( FasL ) mRNA in rodents ; it is generally believed that this molecule , expressed on bordering somatic Sertoli cells , bestows an immune privileged status in the testis by eliminating infiltrating inflammatory Fas bearing leukocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To study the immunomodulatory effects of intravesically applied rML , 17 animals from the control group and 15 animals from Group b were asphyxiated at Week 13 , and urinary bladder tissue was analyzed by semiquantitative reverse transcriptase polymerase chain reaction analysis for mRNA expression of interferon gamma , interleukin 10 , and Fas ligand . ^^^ By Week 13 , in the bladder tissue of 15 rML treated animals from Group b , lower expression of interleukin 10 mRNA was measured , whereas the expression levels of interferon gamma mRNA and Fas ligand mRNA were comparable to those of 17 animals from the control group . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Role of Fas ligand expression in promoting escape from immune rejection in a spontaneous tumor model . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To determine the possible contribution of apoptosis in the pathogenesis of acute lung injury ( ALI ) , we investigated Fas antigen ( Fas ) , Fas ligand ( FasL ) , perforin , granzyme A , and granzyme B expressions in a murine model of ALI after intratracheal instillation of Escherichia coli lipopolysaccharide ( LPS : 0 . 3 30 microg ) into the left lung . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL ) , perforin , TNF alpha , IL 1 , and NO have been considered as effector molecule ( s ) leading to beta cell death in autoimmune diabetes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Inducible expression of Fas ligand ( CD 95 ligand ) by activated T cells and the resulting apoptosis of CD 95 bearing cells is a critical component of peripheral T cell homeostasis and cytotoxic effector mechanisms . ^^^ Differential expression of Fas ligand in Th 1 and Th 2 cells is regulated by early growth response gene and NF AT family members . ^^^ Transcriptional control of the expression of Fas ligand has been attributed to a number of factors , including early growth response gene 2 ( Egr 2 ) , Egr 3 , Sp 1 , and NF AT , although a direct contribution of NF AT is controversial . ^^^ The present study confirms a role for Egr factors and indicates that NF AT is essential for optimal expression of murine Fas ligand through a direct interaction with an NF AT consensus element . ^^^ The role of these factors was further defined by studying the differential expression of Fas ligand in Th 1 and Th 2 lines derived from DO11 . 10 TCR transgenic mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We tested the hypothesis that APCs genetically engineered to present an Ag and to express Fas ligand ( FasL ) simultaneously can target and eliminate Ag specific T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fulminant hepatitis by Fas ligand expression in MRL lpr / lpr mice grafted with Fas positive livers and wild type mice with Fas mutant livers . ^^^ BACKGROUND : Fulminant hepatitis in mice could be induced by gene transfection of Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
One of the regulators of the apoptotic cell death programme is the receptor mediated Fas / Fas ligand interaction . ^^^ METHODS : The apoptosis regulating cytokines soluble Fas ( sFas ) and soluble Fas ligand ( sFasL ) were studied in the cerebrospinal fluid ( CSF ) of 31 hydrocephalic children undergoing shunt surgery for symptomatic hydrocephalus and 18 controls . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this study , we have examined the expression and potential role of 10 linked inhibitor of apoptosis protein ( XIAP ) , Fas , and Fas ligand ( FasL ) in the regulation of apoptosis throughout placental development . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
While Fas R expression was not significantly altered during short term culture by such treatment , Fas Ligand ( Fas L ) membrane expression of phytohemagglutinin ( PHA ) stimulated blood lymphocytes was decreased by protease inhibitor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVE : Salivary gland epithelial cells in patients with Sjgren ' s syndrome ( SS ) and in NOD and NODscid mice express Fas and Fas ligand , and these cells die from apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased soluble Fas ligand concentration in tuberculous pleural effusion . ^^^ Fas ligand ( FasL ) is a type 2 membrane protein that plays an important role in the regulation of apoptosis and has an intimate relation with these cells and cytokines . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND AND AIMS : Hepatocyte apoptosis is induced by tumor necrosis factor alpha ( TNF alpha ) and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Specific T cell deletion by transfected human monocytes expressing Fas ligand and antigen . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased Fas ligand expression and activated T lymphocyte apoptosis in islet graft tolerance induced by liver transplantation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
FLIM 58 , a blocking peptide for FAS ligand , reduces apoptotic cell death of allogenic transplanted hepatocytes in spleen . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis in rat spontaneous chronic pancreatis : role of the Fas and Fas ligand system . ^^^ The Fas / Fas ligand ( FasL ) system is suggested to be correlated to the onset of inflammation and apoptosis in various diseases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Factors of relevance to type 1 diabetes include proinflammatory cytokines , nitric oxide , and reactive oxygen species as well as Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Stromal derived factor 1 alpha ( SDF 1 alpha ) induces CD4+ T cell apoptosis via the functional up regulation of the Fas ( CD 95 ) / Fas ligand ( CD95L ) pathway . ^^^ Although SDF 1alpha did not modify the expression of TNF alpha or that of TNF RI and TNF RII , it increased the expression of surface Fas / APO 1 ( CD 95 ) and intracellular Fas ligand ( CD95L ) significantly . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas , Fas ligand , and transfusion immunomodulation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the current study , we analyzed the alterations of Fas structure and the expression of Fas and Fas ligand ( FasL ) and of Fas pathway inhibitors , including soluble Fas ( sFas ) , Fas associated phosphatase 1 ( FAP 1 ) , and bcl 2 , in 50 cases of human HCC . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( CD95L ) is synthesized both on the cell surface membrane and in a soluble form . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Relationship of Fas ligand expression and atresia during bovine follicle development . ^^^ Fas initiates apoptosis in sensitive cells after binding Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL ) transfected 293 cells released a considerable amount of soluble FasL , and coexpression of neither mTACE nor sTACE enhanced this shedding . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CTLA 4 Fas ligand functions as a trans signal converter protein in bridging antigen presenting cells and T cells . ^^^ Co stimulator blockade and trans inhibitory signaling , using agents such as CTLA 4 Ig and Fas ligand ( FasL ) respectively have been invoked as alternative strategies for suppressing pathogenic T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To further explore the role of ceramide in capping of Fas , we employed FLAG tagged soluble Fas ligand ( sFasL ) , which binds trimerized Fas but is unable to induce capping or apoptosis in Jurkat cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Western blotting showed that treatment of cells with RGD tachyplesin could activate caspase 9 , caspase 8 , and caspase 3 and increase the expression of the Fas ligand , Fas associated death domain , caspase 7 , and caspase 6 , suggesting that apoptotic molecules related to both mitochondrial and Fas dependent pathways are involved in the induction of apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These include mutational escape , latency , masking of antibody binding sites on the viral envelope , downmodulation of the class 1 major histocompatibility complex ( MHC 1 ) , and upregulation of the Fas ligand on the surface of infected cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Elevated levels of caspase 3 , c Jun , and Fas ligand were found , in addition to a corresponding increase in c Jun protein and activation of caspase 3 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , the nature of the death receptors , which may be used by the immune system to control T cells that have not acquired susceptibility to Fas ligand or TNF , is not established . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although similar tyrosine phosphorylation and calcium influx were induced after either pre TCR or alphabetaTCR cross linking , the two pathways diverged at the level of Fas ligand induction . ^^^ Among putative transcription factors involved in Fas ligand mRNA induction , Nur 77 and NFAT transcriptional activities were readily induced after alphabetaTCR , but not pre TCR , stimulation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
IL 4 dependent hepatitis was associated with increases in the intrahepatic levels of IFN gamma , TNF alpha , and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Endotoxin as well as Fas / Fas ligand ( FasL ) have been shown to augment lymphocyte apoptosis ; however , their contribution to the increase of apoptosis in LP B cells during sepsis is not known . ^^^ Furthermore , Fas ligand deficiency appeared to improve survival of septic challenge . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We examined whether the Fas ( APO 1 / CD95 ) / Fas ligand system mediates apoptosis in rats with ventromedial hypothalamus ( VMH ) lesions . ^^^ Northern and Western blotting indicated that VMH lesions lead to a significant increase in Fas mRNA and protein expression from day 1 to day 7 and in Fas ligand mRNA and protein expression from day 2 to day 7 . ^^^ Immunohistochemistry indicated that the region of strongest Fas expression shifted from acinar zone 1 to zones 2 and 3 by day 7 after VMH lesioning and that at days 2 7 Fas ligand positive hepatocyte cell membranes and cytoplasm were randomly distributed in acinar zones 1 3 . ^^^ Vagal firing after VMH lesioning may stimulate Fas / Fas ligand system mediated apoptosis through the cholinergic system in the rat liver . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
During sepsis syndromes , lymphocyte apoptosis can be triggered by the absence of IL 2 or by the release of glucocorticoids , granzymes , or the so called ' death ' cytokines : tumor necrosis factor alpha or Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Treatment with a plant alkaloid or retrorsine , or preparative irradiation of the liver can be used to inhibit host hepatocellular proliferation , while partial hepatectomy , expression of Fas ligand , or thyroid hormone administration can be used as a mitotic stimulus to the transplanted cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand are expressed in 50 % to 80 % of the epithelial cells in all studied tumors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Therefore , cryostat sections of 49 head and neck squamous cell carcinomas ( HNSCC ) were investigated immunohistochemically for pro apoptotic factors caspase 3 and Fas ligand ( FasL ) using a standard streptavidin biotin complex procedure . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Triggering of Fas , a member of the tumor necrosis factor ( TNF ) receptor superfamily , by anti Fas antibodies or by the Fas ligand ( FasL ) , has been shown to cause cell death by apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This `` second hit ' ' could cause more lipid peroxidation , cytokine induction , Fas ligand induction , and fibrogenesis than in primary steatohepatitis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Trophoblasts do not express MHC class 1 or 2 , except HLA C and G , but express Fas ligand ( FasL ) , which confers immune privilege . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TGF beta had no effect on mitogen induced up regulation of Fas ( CD 95 ) or Fas ligand and did not enhance killing of the Fas sensitive Jurkat cell line by activated T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : In vitro , thymidylate synthase ( TS ) inhibition by 5 fluorouracil ( 5 FU ) induces thymineless apoptosis possibly via Fas receptor Fas ligand interactions and cell cycle arrest . ^^^ In frozen tissue sections from liver metastases immunohistochemistry was performed with antibodies directed against p 53 , p 21 , E2F2 , Rb , Ki 67 and TS ( cell cycle related ) and bax , BCL 2 , BCL 10 , mcl 1 , PARP , caspase 3 , Fas receptor and Fas ligand ( apoptosis related ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Determination of cytokine mRNA in the course of Fas mediated apoptosis in the presence of Tf or Tf Gly showed upregulation of mRNA for Fas ligand and TNF alpha in CD 56 ( + ) and downregulation of these transcripts along with upregulation of mRNA for interleukin 10 in CD 3 ( + ) marrow cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : Interaction between Fas antigen on hepatocytes and Fas ligand on cytotoxic T cells induces apoptosis , a major mechanism of hepatitis C virus ( HCV ) induced hepatocyte injury . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Therefore , the Fas Fas ligand system in human brain tumors may be involved not only in apoptotic processes but also in the provocation of angiogenic and proinflammatory responses . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast to recent findings , JNK / SAPK activation did not correlate with Fas or Fas ligand ( FasL ) expression , suggesting that the Fas / FasL system is not involved in hypoxia induced apoptosis in melanoma cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
DNA analysis studies using the molecular biology techniques which were done in the Department of Internal Medicine 2 , Fukushima Medical University were presented . 1 ) Nucleic acid sequences of the cloned DNA polypeptide fragments in the serum of patients with systemic lupus erythematosus . 2 ) SSCP analysis for clonality of Vb repertoires in T cell receptors in the patients with rheumatoid arthritis , primary biliary cirrhosis or CREST syndrome . 3 ) Detection of mRNA of TNFa and Fas ligand in the mononuclear cells ( FICL PCR ) in the synovial fluids of RA patients . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Induction of apoptosis and Fas receptor / Fas ligand expression by ischemia / reperfusion in cardiac myocytes requires serine 727 of the STAT 1 transcription factor but not tyrosine 701 . ^^^ Moreover , STAT 1 is critical for the induction of Fas receptor and Fas ligand expression by ischemia / reperfusion ( I / R ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( Apo 1 / CD95 ) is a cell surface receptor involved in cell death signaling through binding of Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
T ( h ) 1 cells are cytotoxic effector cells that utilize Fas ligand ( FasL ) and tumor necrosis factor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Differential use of Fas ligand and perforin cytotoxic pathways by donor T cells in graft versus host disease and graft versus leukemia effect . ^^^ The relative contributions of the Fas ligand ( FasL ) and perforin cytotoxic pathways in GVHD and GVL activity were studied by using FasL defective or perforin deficient donor T cells in murine parent > F 1 models for allogeneic bone marrow transplantation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , neither doxorubicin nor sphingosine treatment affected expression of Fas ligand or induced activation of the apical caspase 8 , indicating a Fas / Fas ligand independent mechanism . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Direct in vivo transfection of antisense Fas ligand reduces tumor growth and invasion . ^^^ The expression of Fas ligand ( FasL ) by tumor cells has been reported to have multiple , conflicting effects on tumor growth . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activation of the Fas pathway independently of Fas ligand during apoptosis induced by camptothecin in p 53 mutant human colon carcinoma cells . ^^^ Under such conditions , Fas , Fas ligand , Bax , and p 21 expression were increased and Fas recruited the FADD adaptor . ^^^ The anti Fas blocking antibody ZB 4 and the Fas ligand inhibitor failed to protect HT 29 cells from CPT induced apoptosis . ^^^ Together , these data show that topoisomerase 1 mediated DNA damage induced apoptosis involves activation of the Fas pathway without detectable Fas ligand requirement in CPT treated cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The aim of this study was to evaluate whether chronic sialadenitis would also occur in Fas ligand ( FasL / CD95L ) mutant B 6 gld / gld mice upon infection with MCMV and whether the expression of FasL by local gene transfer using recombinant adenoviral vectors would be an effective therapeutic strategy . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , expression of Fas ligand was detected in granulosa cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A cascade of events has evolved , starting with specific stimuli and developing over different mediators and regulators ( e . g . , Fas ligand , proteins of the Bcl 2 family , p 53 ) to effector enzymes ( caspases ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand is a member of the tumor necrosis factor family that can induce both apoptosis and activation of various cells . ^^^ While Fas ligand gene transfer indeed eliminates cancer cells and inflammatory cells through apoptosis , it also kills normal cells and initiates inflammation in certain tissues . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Western blot analysis revealed that , in IFN gamma differentiated U 937 cells , the expression of Fas ( CD95 / APO 1 ) & Fas ligand ( FasL ) increases the apoptotic sensitivity against Mistletoe lectin 2 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The pro apoptotic factors Fas Ligand and Trail . ^^^ An area of particular interest has been the induction of apoptosis by two death receptor / ligand pairs , Fas / Fas Ligand and DR 4 DR5 / TRAIL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The lpr and gld genes are a Fas deletion mutant and a Fas ligand mutant , respectively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To gain further insight into such mechanisms we performed an exhaustive comparative analysis of the expression of key molecules regulating cell death ( Fas , Fas ligand [ FasL ] , Bcl 2 ) and apoptosis in both thyrocytes and thyroid infiltrating lymphocytes ( TILs ) from patients with either GD or HT . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas and Fas ligand mRNA in rat and human preimplantation embryos . ^^^ The Fas Fas ligand ( L ) system is one of the major signalling pathways to induce apoptosis in various cells and tissues . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Veto activity of activated bone marrow does not require perforin and Fas ligand . ^^^ In vitro cytotoxicity of ABM depends largely on the perforin / granzyme and Fas / Fas ligand pathways . ^^^ Utilizing perforin deficient and functional Fas ligand deficient gld mice as a source of ABM and functional Fas deficient lpr mice as a source of precursor CTL , we demonstrate in this study that ABM cells utilize a perforin and Fas independent pathway to veto allogeneic cell mediated cytotoxic responses . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We describe a strategy for specific immunotherapy of myasthenia gravis ( MG ) based on genetic engineering of antigen presenting cells ( APCs ) to present the autoantigen acetylcholine receptor ( AChR ) and express the `` warhead ' ' Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This reduction in GVHD was related to IFN gamma production since cells expanded from IFN gamma knock out animals caused acute lethal GVHD , whereas cells expanded from animals defective in fas ligand , fas , IL 2 , and perforin did not . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The increased hepatitis seen in CD 44 KO mice was accompanied by increased production of cytokines such as TNF alpha , IL 2 and IFN gamma , but not Fas or Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Several laboratories have proposed that expression of Fas ligand ( L ) by tumor is the basis for this form of T cell tolerance . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Correlation of Fas and Fas ligand expression with rejection status of transplanted heart in human . ^^^ The role of Fas and Fas ligand ( FasL ) in graft rejection is not fully understood , and the expression changes of these genes in human transplanted heart have not been elucidated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand in gastric carcinoma relates to lymph node metastasis . ^^^ The Fas ( CD95 / APO 1 ) / Fas ligand ( FasL ) system is one of the major apoptotic pathways . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RT PCR analyses showed that 10 different RCC cell lines expressed Fas , but not Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
All lines produced Fas ligand ( FasL ) and had comparable levels of Fas receptor , FasL , Fas associated death domain protein , and caspases 3 and 6 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of fas ligand , caspase 3 and baxalpha changes differentially or remain unaffected . tTG expression did not change significantly after administration of either the peroxisome proliferator activated receptor alpha agonist WY 14643 or the retinoid 10 receptor specific analog LG 100268 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We hypothesize that expression of Fas may play a role in the elimination of metastatic tumor cells in the lung , an organ in which Fas ligand is expressed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
PI 3 K inhibition during CTL induction resulted in decreased levels of mRNAs coding for granzyme B , perforin , and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVES : The aim of the study was to investigate whether apoptosis may contribute to the pathogenesis of cutaneous changes in LE and whether certain apoptosis related markers such as Fas antigen , Fas ligand ( FasL ) , Bcl 2 and Bax proteins take part in this process . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Depletion of both NK and NKT cells in B 6 mice reduced all these effects of alpha GALCER : Injection of Abs to IFN gamma also inhibited the alpha GalCer induced increase in antitumor cytotoxicity of MNCS : alpha GalCer induced the expression of Fas ligand on NKT cells in the liver of B 6 mice . ^^^ Moreover , NKT cells mediate alpha GalCer induced hepatocyte injury through Fas Fas ligand signaling . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand overexpression on allograft endothelium inhibits inflammatory cell infiltration and transplant associated intimal hyperplasia . ^^^ Here we show that endothelial cells can be genetically modified to overexpress functional , cell surface Fas ligand ( FasL ) by adenovirus mediated gene transfer without undergoing self destruction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVE : To determine whether overexpression of the Fas ligand ( FasL ) on activated lpr T lymphocytes could induce arthritic lesions when grafted into syngeneic wild type MRL mice expressing normal Fas receptor levels . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Granulosa cells isolated before the LH surge were susceptible to apoptosis induced by soluble Fas ligand or serum withdrawal , while cells isolated after the LH surge were resistant to apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Elevated serum soluble Fas ligand in histiocytic necrotizing lymphadenitis . ^^^ In this study , we evaluated the serum levels of soluble Fas ligand ( sFasL ) in 30 HNL patients using paired sera . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ( CD 95 ) and Fas ligand on peripheral blood mononuclear cells in critical illness and association with multiorgan dysfunction severity and survival . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In particular , dysfunction of the Fas apoptotic pathway or production of soluble factors including soluble Fas and soluble Fas ligand may be involved in the pathogenesis of these disorders . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of CD 40 ligand , interferon gamma and Fas ligand genes in endomyocardial biopsies of human cardiac allografts : correlation with acute rejection . ^^^ The purpose of the present study was to investigate the expression ( mRNA ) of CD 40 ligand ( CD40L ) , interferon gamma ( IFN gamma ) and Fas ligand ( FasL ) genes in human cardiac allografts in relation to the occurrence of acute cardiac allograft rejection as well as its possible value in predicting acute rejection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Mutations of Fas or Fas ligand genes result in the autoimmune lymphoproliferative syndrome ( ALPS ) in humans . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : Anti human class 1 , class 2 , and Fas ligand monoclonal antibodies were used against cryopreserved amniotic membrane and cell viability tested for cryopreserved amniotic membrane . ^^^ Fas ligand positive cells were also detected in mesenchymal cells of amniotic stroma . ^^^ CONCLUSIONS : Amniotic membrane seems to be immune privileged tissue and to contain some immunoregulatory factors , including HLA G and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Fas ligand associated apoptosis in experimental autoimmune uveoretinitis in rodents : role of proinflammatory corticotropin releasing hormone . ^^^ In this study , we examined the role of apoptosis in the destruction of the retina during experimental autoimmune uveoretinitis , and the role of corticotropin releasing hormone as a local regulator of Fas and Fas Ligand expression in this condition . ^^^ We evaluated apoptosis by the terminal deoxynucleotidyl transferase dUTP nick end labeling method and Fas and Fas Ligand presence by immunohistochemistry . ^^^ The percentage of retinal cells undergoing apoptosis and the expression of Fas and Fas Ligand were increased in inflamed retinas in immunized Lewis rats and B10 . ^^^ A mice treated with anti corticotropin releasing hormone antibody showed significantly lower apoptosis and Fas and Fas Ligand expression than placebo treated animals . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas associated death domain protein ( FADD ) and caspase 8 mediate up regulation of c Fos by Fas ligand and tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) via a FLICE inhibitory protein ( FLIP ) regulated pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( CD 95 ) and Fas ligand ( FasL / CD95L ) are involved in programmed cell death and the regulation of host immune responses . ^^^ Expression of human Fas ligand on mouse beta islet cells does not induce insulitis but is insufficient to confer immune privilege for islet grafts . ^^^ Fas ( CD 95 ) and Fas ligand ( FasL / CD95L ) are involved in programmed cell death and the regulation of host immune responses . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , few apoptotic cells were associated with neighboring cells which were positive for either Fas ligand or TNF . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas is the death receptor , transducing cell death signaling upon stimulation by Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The thymic lymphomas in Atm DeltaSRI mice were characterized by extensive apoptosis , which appears to be attributable to an increased number of cells expressing Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The mRNA levels for CTL genes ( perforin , granzyme B , and Fas ligand ) were similar in rejecting kidneys in WT and GKO hosts , and the host Ab responses were similar . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL ) is considered to have similar roles . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Last , we also examined MM and NHL B cell lines , as well as patient tumor cells , for the expression of other antigens that may have a role in blocking ADCC activity , such as Fas ligand ( FasL ) , MUCI , or TRAIL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We performed an immunohistochemical analysis of apoptosis and the expression of apoptosis related proteins ( ARP ) such as Fas and Fas ligand ( FasL ) , bcl 2 and p 53 in human ovarian epithelial tumors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A mutation in the ligand for Fas ( Fas ligand ; CD 95 ligand , Apo 1 ligand ) , which induces apoptosis upon binding to Fas , was described in a patient with systemic lupus erythematodes and lymphadenopathy . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
One of the most prominent glucocorticoid induced genes is glucocorticoid induced leucine zipper ( GILZ ) , which has been reported to inhibit activation induced up regulation of Fas ligand ( FasL ) mRNA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis in cultured rat islets of langerhans and occurrence of Bcl 2 , Bak , Bax , Fas and Fas ligand . ^^^ At designated intervals , histologic sections were treated with the direct fluorescein labelled TUNEL method and immunostained for pancreatic hormones ( glucagon , insulin ) and apoptotic peptides [ Bak , Bax , Fas , Fas ligand ( FasL ) ] , as well as for the anti apoptotic peptide Bcl 2 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas and Fas ligand was performed by FACS on B cell subpopulations from five HIV 1 infected and four uninfected subjects . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In connection with this result we found that 7 , 8 dihydroneopterin can increase Fas ligand expression detected in Western blot analysis and promoter reporter assays . ^^^ Antioxidants potently reduced the effect of 7 , 8 dihydroneopterin on Fas ligand promoter activation suggesting an involvement of oxidative stress . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Alterations in the expression of several genes detected during tumor progression were consistent with their functional activities involving growth ( p 21 , p 27 , and cyclin D 1 ) , resistance and apoptosis ( glutathione S transferase , cIAP 1 , PEA 15 , and Fas ligand ) , inflammation and angiogenesis [ chemokine growth regulated oncogene 1 ( also called KC ) ] , and signal transduction ( c Met , yes associated protein , and syk ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis of vascular smooth muscle cells is induced by Fas ligand derived from endothelial cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In vivo inhibition of Fas ligand mediated killing by TR 6 , a Fas ligand decoy receptor . ^^^ TR 6 , a member of the tumor necrosis factor ( TNF ) receptor superfamily , has recently been shown to bind to Fas ligand ( FasL ) and inhibit FasL mediated cell killing in vitro . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
One set studied the expression of Fas , Fas ligand , caspase 8 , Fas associated death domain , and tumor necrosis factor receptor associated death domain genes and the second set studied the expression of caspase 2 , 4 , 6 , 7 , and 10 . ^^^ Neither lipopolysaccharide nor tumor necrosis factor induced Fas ligand expression in human fetal membranes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The following parameters were assessed : plasma aspartate : 2 oxoglutarate aminotransferase activity ( AST ) ; liver histology and terminal deoxyribonucleotidyl transferase mediated dUTP nick end labeling ( TUNEL ) response ; caspase 3 , 8 , and 9 activity ; and mRNA and protein expression for two apoptosis signaling molecules : Fas receptor and Fas ligand ; and three apoptosis adaptors : Bax , Bcl XL , and Bcl 2 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Hepatoma cells were inoculated subcutaneously into 6 week old rats , and 4 months later the quantities of T and B cells , macrophages , and cells positive for Fas , Fas ligand ( FasL ) and interleukin 2 ( IL 2 ) were immunohistochemically evaluated in spleens . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Positive and negative consequences of soluble Fas ligand produced by an antigen specific CD 4 ( + ) T cell response in human carcinoma immune interactions . ^^^ Using this patient derived T cell line as a potentially relevant cell type , we examined the consequences of the anti carcinoma CD 4 ( + ) T cell response , with emphasis on specific lymphokines potentially important for the regulation of Fas / Fas ligand ( FasL ) interactions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand induced caspase 1 dependent accumulation of interleukin 18 in mice with acute graft versus host disease . ^^^ In contrast , recipients having transplantation with gld / gld spleen cells , which lack functional Fas ligand ( FasL ) , contained only normal ranges of IL 18 , indicating FasL mediated IL 18 release in aGVHD . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , engagement of Ly49A selectively inhibited TCR induced Fas ligand expression whereas TCR induced Fas expression was not significantly affected . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cross linking of cell surface Fas molecules by Fas ligand or by agonistic anti Fas Abs induces cell death by apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The CD 8 ( + ) GIC from fed animals transcribed substantial levels of perforin , granzyme , and Fas ligand mRNA , indicating the presence of active CTL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , apoptosis mediated by Fas ligand ( FasL ) involving Akt activation also was potentiated by DMS pretreatment in Hc cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
B Myb overexpression results in activation and increased Fas / Fas ligand mediated cytotoxicity of T and NK cells . ^^^ Overexpression of B Myb had no measurable effect on the subsets of splenic and thymic lymphocytes , but was associated with increased expression of Fas ligand in NK and T cells . ^^^ Ex vivo cultured transgenic thymocytes and splenocytes had decreased survival compared with the corresponding cells from wt mice , possibly dependent on increased expression of Fas ligand . ^^^ In addition , Fas ligand dependent cytotoxicity of transgenic T and NK cells was significantly higher than that mediated by their wt counterparts . ^^^ Therefore , in addition to its well established role in proliferation and differentiation , B myb also appears to be involved in activation of NK and T cells and in their regulation of Fas / Fas ligand mediated cytotoxicity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand ( FasL ) were constantly expressed on apical membranes of amniotic epithelial cells from weeks 16 27 through to 40 41 of gestation , while no Bcl 2 expression was observed throughout the gestational periods . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Bax , Bcl 2 , Fas , and Fas ligand expression was analyzed by competitive reverse transcription PCR . ^^^ No consistent significant change in glomerular Bax , Bcl 2 , Fas , and Fas ligand mRNA was evident by reverse transcription PCR , although focal increases in glomerular Bcl 2 mRNA were demonstrated by in situ hybridization . ^^^ Total renal Bax , Fas , and Fas ligand mRNA were upregulated in the PAN model , peaking at week 17 ( P < 0 . 01 versus sham ) , whereas Bcl 2 mRNA was not significantly different in PAN versus sham controls . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TRAIL was the most potent inducer of apoptosis when compared to Fas ligand or TNF . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To investigate the regulatory mechanisms of neutrophil apoptosis associated with HPWE , mRNA expression and protein production of Fas , Fas ligand ( FasL ) and tumor necrosis factor receptor 1 ( TNF R 1 ) were analyzed by RT PCR , ribonuclease protection assay , Northern blot and Western blotting . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Lack of correlation between clinical characteristics and serum soluble Fas ligand levels in patients with multiple myeloma . ^^^ Villunger et al . showed that the neoplastic plasma cells express Fas ligand ( FasL ) , which transmits a signal of apoptosis upon ligation to Fas , and suggested that the FasL suppresses the T cells activated against malignant cells , resulting in escape from tumour immunity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Molecular cloning , characterization , and expression of porcine Fas ligand ( CD 95 ligand ) . ^^^ We isolated and sequenced cDNA that contained the coding sequence of porcine Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
While cell surface expression of apoptosis related molecules such as TNF related apoptosis inducing ligand ( TRAIL ) , TRAIL receptors , CD 95 ( Fas ) and Fas ligand , and plasma interferon gamma were increased for measles patients , they remained unchanged after vaccination . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interferon gamma and Fas ligand expression were up regulated , and host lymphocytes were depleted in the target organs of these mice . ^^^ Transplantation of Fas ligand deficient ( gld ) spleen cells did not induce host lymphocyte depletion in target organs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand triggers pulmonary silicosis . ^^^ We investigated the role of Fas ligand in murine silicosis . ^^^ Strikingly , Fas ligand deficient generalized lymphoproliferative disease mutant ( gld ) mice did not develop silicosis . ^^^ Bone marrow chimeras and local adoptive transfer demonstrated that wild type , but not Fas ligand deficient lung macrophages recruit neutrophils and initiate silicosis . ^^^ Silica induced Fas ligand expression in lung macrophages in vitro and in vivo , and promoted Fas ligand dependent macrophage apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cytotoxic lymphocytes may induce apoptosis in their target cells by the FasL ( Fas ligand ) pathway or the perforin / granzyme B pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Decreased Fas expression during tumor progression often results in a loss of Fas ligand ( FasL ) mediated apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here we show that NF kappaB activation upregulates the caspase 8 inhibitor FLIP , resulting in increased resistance to Fas ligand ( FasL ) or TNF . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Functional characterization of Fas ligand on tumor cells escaping active specific immunotherapy . ^^^ The ability of these escape tumors to grow appeared to be due to upregulation of the Fas ligand ( Fas L ) molecule . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ( APO 1 / CD95 ) and Fas ligand ( FasL ) in human neuroblastoma . ^^^ In contrast , Fas ligand was detected in only a small subset of cell lines . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It has been previously shown that CD4+ T cells enter the apoptotic suicide program via the Fas ligand ( FasL ) / Fas mediated pathway upon T cell receptor ( TCR ) stimulation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Constitutive Fas ligand ( FasL ) expression by specialized cells in the body participates in the immune privilege status of tissues containing these cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Significance of serum soluble Fas ligand in patients with bladder carcinoma . ^^^ BACKGROUND : The interaction of Fas and Fas ligand ( FasL ) plays an important role in cytotoxic T lymphocyte mediated and natural killer cell mediated apoptosis against tumor cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble human Fas ligand ( Fas L ) was determined by enzyme linked immunosorbent assay ( ELISA ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Colitis is accompanied by activation and apoptosis of Fas ligand and TNF alpha expressing CD 4 ( + ) T cells in the diseased colonic lamina propria ( Eur . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cytotoxic lymphocytes kill tumor or virus infected target cells utilizing two mechanisms ( 1 ) release of lytic granules ( containing perforin and granzymes ) and ( 2 ) Fas ligand ( FasL ) / Fas or TNF initiated apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas belongs to the tumour necrosis factor ( TNF ) / nerve growth factor superfamily and engagement by Fas ligand induces apoptosis in various epithelial cells . ^^^ To investigate the role of apoptosis and associated mechanisms , we examined the occurrence of apoptosis and Fas and Fas ligand expression , and the therapeutic effect of alpha melanocyte stimulating hormone ( alpha MSH ) , a potent anti inflammatory cytokine in an ischaemic acute renal failure ( ARF ) rat model . ^^^ The expression of Fas and Fas ligand was studied by western blot analysis and semiquantitative reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ The degree of apoptosis , neutrophil infiltration , and Fas and Fas ligand , and ICAM 1 expression , as well as biochemical and histological data were compared between the alpha MSH and the vehicle treated groups . ^^^ Ischaemia caused an increase in Fas and Fas ligand expression and was accompanied by morphological evidence of apoptosis . alpha MSH significantly reduced the degree of apoptosis , as well as Fas and Fas ligand expression ( mean apoptotic cell number , 41 . 7+ / 3 . 5 / 14 . 2+ / 2 . 2 per x 200 field at 24 h after ischaemia . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
There was a significant correlation between the levels of IL 18 and soluble Fas ligand in colostrum ( p = 0 . 0003 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The accumulation of membrane Fas , the Fas ligand , and TNFR 1 were not apparent due to exposure to SI 27 , and antagonistic anti Fas or anti Fas ligand antibodies did not block SI 27 induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas and soluble Fas ligand levels in patients with acute hepatic failure . ^^^ PURPOSE : The Fas ligand ( FasL ) / Fas system is an apoptosis induction system that plays an important role in homeostasis and biophylaxis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The immune attack staged by cytotoxic T lymphocytes is carried out by one of two distinct modes of lymphocytotoxicity : ( a ) secretion of lytic granules containing the pore forming protein perforin and a family of serine proteases ( i . e . , granzymes ) and ( b ) interaction between the lymphocyte Fas ligand and the target cell Fas receptor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Therefore , we studied the cell cycle proteins , Rb , E2F2 , Ki 67 , p 21 and p 53 and the apoptotic proteins , mcl 1 , hax , bcl xl , bcl 2 , Fas receptor , Fas ligand , caspase 3 , M 30 and PARP as potential predictive factors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas ligand ( 0 . 1 microg / ml ) in the presence of actinomycin D ( 0 . 05 microg / ml ) induced apoptosis in cultured adult rat cardiomyocytes , as documented by activated caspase 3 , DNA fragmentation , and apoptotic ultrastructure . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Fas ligand deficiency results in altered localization of anti double stranded DNA B cells and dendritic cells . ^^^ Autoantibodies directed against dsDNA are found in patients with systemic lupus erythematosus as well as in mice functionally deficient in either Fas or Fas ligand ( FasL ) ( lpr / lpr or gld / gld mice ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In vitro immunosuppressive activity of soluble HLA class 1 and Fas ligand molecules : do they play a role in autologous blood transfusion . ^^^ RESULTS : The concentrations of soluble Fas ligand and HLA class 1 molecules were higher in packed RBCs than in WBC reduced RBCs , FFP , and serum . ^^^ The immunomodulatory effects were correlated with the amount of soluble Fas ligand and HLA class 1 molecules . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A resistant human melanoma cells are shown to expropriate the Fas ligand to Fas receptor ( CD 95 ; APO 1 ) ( FasL > FasR ) system for their autocrine growth loop not only in melanoma cells coexpressing CD 95 and its ligand but also in CD 95 positive melanoma cells undergoing divisions when exposed to CD 95 ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Caspase 1 , 3 , 8 , and 9 activities were elevated in SMG C 6 cells after the induction of apoptosis by soluble Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Control of murine cytomegalovirus replication in salivary glands during acute infection is independent of the Fas ligand / Fas system . ^^^ The course of mouse cytomegalovirus ( MCMV ) infection was compared between mutant C57BL / 6 ( B 6 ) mice deficient in either perforin ( perf / ) , or perforin , granzyme A and B ( perfxgzmAxB / ) , and B 6 gld mice lacking functionally active Fas ligand to elucidate the contribution of the two main cytolytic pathways in the early control of MCMV infection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We studied the relationship between sepsis severity and peripheral blood monocyte Delta ( Psi ) m , cell death ( necrosis and apoptosis ) , soluble Fas ligand , Hsp 70 , and Bcl 2 expression over time in 18 patients with sepsis , and compared these data with those of a group of 17 healthy control subjects . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The membrane bound but not the soluble form of human Fas ligand is responsible for its inflammatory activity . ^^^ The ectopic expression of Fas ligand ( FasL / CD95L ) in tissues or tumors induces neutrophil infiltration and the destruction of the tissues or the rejection of tumors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
They express upregulated Fas and Fas ligand and undergo activation induced apoptosis . ^^^ Skin infiltrating T cells in AD are protected from activation induced cell death , although they express both Fas and Fas ligand . ^^^ Keratinocyte apoptosis is induced by Fas ligand , either soluble or expressed on the surface of T cells , leading to eczema formation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunohistochemical detection of Fas and Fas ligand in sarcomatoid renal cell carcinoma . ^^^ Cytokeratin , epithelial membrane antigen , vimentin , desmin , smooth muscle actin , CD 34 , S 100 protein , MIB 1 , p 53 , Fas and Fas ligand immunohistochemical expression was investigated in seven renal cell carcinomas with sarcomatoid changes . ^^^ No significant difference between sarcomatoid and nonsarcomatoid areas was observed with the different biomarkers , excepted for Fas ligand . ^^^ However , Fas ligand had a higher expression in sarcomatoid in comparison to nonsarcomatoid areas . ^^^ Our results showed that Fas and Fas ligand are both expressed in renal cancer . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We tested the hypothesis that an adenovirus vector expressing Fas ligand can be used to induce apoptosis in the prostate . ^^^ Infection of all three primary prostate cell types with an adenovirus vector that expresses Fas ligand ( AdFasL / G ) resulted in rapid apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVE : To assess whether serum levels of soluble Fas and soluble Fas ligand are altered in the syndrome of hemolysis , elevated liver enzymes , and low platelets ( HELLP ) . ^^^ RESULTS : Both soluble Fas and soluble Fas ligand were detected in the sera of normal pregnancies as well as in those with HELLP syndrome . ^^^ However , there was no significant difference in mean serum soluble Fas ligand levels of the two groups ( 0 . 60 + / 0 . 06 compared with 0 . 50 + / 0 . 22 ng / mL , P = . 23 ) . ^^^ In women with HELLP syndrome , there were no significant correlations between serum levels of soluble Fas or soluble Fas ligand with liver transaminases ( aspartate and alanine aminotransferase ) and platelet count . ^^^ CONCLUSION : Serum levels of soluble Fas , but not soluble Fas ligand , are significantly higher in women with HELLP syndrome than healthy gravidas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of matrix metalloproteinase 2 ( MMP 2 ) , plasminogen activator inhibitor 1 ( PAI 1 ) and interleukin 1 ( IL 1 alpha ) were upregulated in the highly metastatic subpopulations , while the expression of carcinoembryonic antigen ( CEA ) , caspase 5 , Fas ligand , Prk / FNK , cyclin E , cyclin B 1 , Ki 67 , proliferating cell nuclear antigen ( PCNA ) , Smad 4 , macrophage proinflammatory human chemokine 3 alpha ( MIP 3 alpha ) / LARC , Met and CD 44 were downregulated . ^^^ Data from the literature suggest that the altered expression of MMP 2 , PAI 1 , IL 1 alpha , CEA , caspase 5 , Fas ligand , Prk / FNK and Smad 4 promotes the highly metastatic phenotype . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , it is unclear to what extent the two main cytolytic pathways , perforin granzyme A and B exocytosis and Fas ligand ( FasL ) Fas interaction , contribute to these processes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 4 ( + ) and CD 8 ( + ) T cells kill intracellular Mycobacterium tuberculosis by a perforin and Fas / Fas ligand independent mechanism . ^^^ After stimulation in vitro with MTB , both CD 4 ( + ) and CD 8 ( + ) T cells up regulated mRNA expression for granzyme A and B , granulysin , perforin , and CD95L ( Fas ligand ) . mRNA levels for these molecules were greater for resting CD 8 ( + ) than CD 4 ( + ) T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tat , like Fas ligand , induced cleavage of chromatin structure , as evidenced by changes in DNA laddering , incorporation of fluorescein into the nicked chromosomal DNA ( TUNEL assay ) , and mono or oligonucleosomes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : Fas and Fas ligand expression were assessed by flow cytometry and immunocytochemistry . ^^^ RESULTS : LPLs and IELs showed increased apoptotic activity and higher levels of Fas ligand expression in untreated CD compared with treated CD patients and controls . ^^^ CONCLUSIONS : Our results support the involvement of the Fas / Fas ligand system in CD associated enterocyte apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Autoimmune lymphoproliferative syndrome ( ALPS ) , caused by inherited defects in apoptosis secondary to mutations in genes encoding Fas / CD95 / APO 1 and Fas ligand ( Fasl ) / CD95L , is characterized by nonmalignant lymphadenopathy and splenomegaly , increased T cell receptor alpha / beta ( + ) CD 4 ( ) CD 8 ( ) T cells ( alpha / beta ( + ) double negative T cells [ alpha / beta ( + ) DNT cells ] ) , autoimmunity , hypergammaglobulinemia , and cytokine abnormalities . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Suppression of Fas ligand expression on endothelial cells by arsenite through reactive oxygen species . ^^^ The present study has demonstrated that arsenite not arsenate decreased the Fas ligand ( FasL ) expression on ECV 304 cells through reactive oxygen species . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here , we report that K 8 null mouse hepatocytes in primary culture and in vivo are three to fourfold more sensitive than wild type ( WT ) mouse hepatocytes to Fas mediated apoptosis after stimulation with Jo 2 , an agonistic antibody of Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunolocalization of FAS and FAS ligand in inflammatory myopathies . ^^^ Fas / Fas ligand ( FasL ) interaction can induce apoptosis , have a costimulatory role or act as a mechanism by which cytotoxic T cells produce target cell lysis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , estrogen receptors , progesterone receptors , and apoptosis associated proteins , Fas , Fas ligand , and Bax were expressed in both endometriosis and carcinoma tissues of the tumor , whereas Bcl 2 was not expressed in either tissue of the tumor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression and depletion of T cell infiltration in astrocytic tumors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , the expression of Fas ligand ( FasL ) mRNA was markedly induced temporarily before the activation of caspase 3 by the treatment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas and Fas ligand in uveal melanoma : biological implication and prognostic value . ^^^ The interaction between Fas and Fas ligand is one possible immune escape mechanism used by tumour cells . ^^^ In the present study , melanoma tissue from 103 patients who underwent enucleation for malignant uveal melanoma ( iris melanomas excluded ) was stained by immunohistochemistry with monoclonal antibodies specific for Fas , Fas ligand , CD 3 , CD 8 , and CD 68 . ^^^ Both Fas and Fas ligand were detected in uveal melanomas . ^^^ The metastasis free 5 year survival rates in the univariate analyses were considerably lower in patients with tumours that lacked Fas ligand expression ( < 35 % of the tumour cells ) , in the presence of more than 50 CD 8 positive cells in 20 high power fields and in the presence of more than 100 CD 3 positive cells in 20 high power fields . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To investigate the roles of apoptosis and the Fas system ( Fas , Fas ligand , soluble Fas ) in the process of liver cirrhosis ( LC ) converting into hepatocellular carcinoma ( HCC ) , expression of Fas and Fas ligand ( FasL ) in 49 LC and 36 HCC samples was detected by immunohistochemical method . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
HSV tk / GCV , but not PNP / fludarabine , caused up regulation of Fas in p 53 positive HepG 2 cells and of Fas ligand ( FasL ) in both HCC cell lines . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activation induced cell death ( AICD ) , a Fas ligand ( FasL ) dependent pathway , is important for maintaining T cell homeostasis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand / Fas mediated apoptosis in human coronary artery smooth muscle cells : therapeutic implications of fratricidal mode of action . ^^^ OBJECTIVE : This study aimed to determine the mode of action of Fas ligand ( FasL ) / Fas at mediating apoptosis so as to evaluate the potential of FasL in gene therapy for restenosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These findings suggest that the receptors for TRAIL , Fas ligand , and TNF play a role in limiting virus infections . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas ligand ( FasL ) / Fas pathway is crucial for the maintenance of homeostasis of the peripheral immune system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Regulation of Fas ligand induced apoptosis by TNF . ^^^ Fas ligand ( FasL , CD95L ) expression helps control inflammatory reactions in immune privileged sites such as the eye . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Humanization and epitope mapping of neutralizing anti human Fas ligand monoclonal antibodies : structural insights into Fas / Fas ligand interaction . ^^^ Fas ligand ( L ) / CD95L , a proapoptotic member of the TNF family , is a potential target for clinical intervention in various diseases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased Fas ligand expression in the tumor tissue and serum of patients with testicular germ cell tumors with seminomatous elements . ^^^ OBJECTIVES : To measure the expression levels of Fas and Fas ligand ( FasL ) in testicular germ cell tumor ( TGCT ) and to determine whether the serum level of soluble FasL ( sFasL ) could be used as a marker for patients with TGCT . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Inverse relation of Fas ligand and tumor infiltrating lymphocytes in angiosarcoma : indications of apoptotic tumor counterattack . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TNFalpha down regulates the Fas ligand and inhibits germ cell apoptosis in the human testis . ^^^ Interestingly , expression of the Fas ligand , a known inductor of testicular apoptosis , was down regulated by TNFalpha . ^^^ Thus , in the seminiferous tubules , germ cell derived TNFalpha may regulate the level of the Fas ligand and thereby control physiological germ cell apoptosis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Changes of Fas and Fas ligand expression were verified by immunohistochemistry and Western blot . ^^^ Immunohistochemistry showed the expression of Fas ligand in all enzymatically treated specimens . ^^^ Upregulation of Fas ligand in matrix depleted specimens suggested that the Fas pathway may have a role in apoptosis induced by matrix depletion . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Inhibition of MAPK potentiated bile acid induced apoptosis in hepatocytes with mutant FAS ligand , but did not enhance in hepatocytes that were null for FAS receptor expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression by neoplastic T lymphocytes mediates elimination of CD8+ cytotoxic T lymphocytes in mycosis fungoides : a potential mechanism of tumor immune escape . ^^^ Because T lymphocyte apoptosis is controlled mainly through the Fas / Fas ligand ( FasL ) pathway and tumor cells may escape immune surveillance by expressing FasL , triggering apoptosis of tumor infiltrating T lymphocytes , we studied the role of this system in MF . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , the soluble form of Fas ligand protein present in the seminal plasma of infertile patients might suggest a role for this immunomodulatory protein in male infertility . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The decreased AICD of T cells from 16 month old mice is associated with a decreased expression of Fas and Fas ligand ( FasL ) , decreased susceptibility to anti Fas induced apoptosis , and an increased expansion of a CD 8 ( + ) T cell population . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Human blood derived macrophages induce apoptosis in human plaque derived vascular smooth muscle cells by Fas ligand / Fas interactions . ^^^ VSMC apoptosis was inhibited by neutralizing antibodies to Fas ligand ( Fas L ) or an Fas Fc fusion protein , indicating the requirement for membrane bound Fas and Fas L . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand is targeted to secretory lysosomes via a proline rich domain in its cytoplasmic tail . ^^^ Fas ligand ( FasL ) induces apoptosis through its cell surface receptor Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Effector T cells from the lungs of both groups of mice were shown to lyse Fas ( CD 95 ) overexpressing target cells in greater numbers than target cells expressing low levels of Fas , suggesting that Fas ligand ( CD95L ) mediated target cell lysis was occurring in vivo . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fluorescence conjugated polyclonal antibodies to Fas and Fas ligand ( FasL ) were used to localize Fas and FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand and TRAIL augment the effect of photodynamic therapy on the induction of apoptosis in JURKAT cells . ^^^ Tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) and Fas ligand ( FasL ) trigger apoptosis by stimulating the formation of a death inducing signaling complex at the cytoplasmic terminus of their respective receptors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Alanine transaminase release in hBcl 2 modified hepatocytes was lower compared with controls , which could not be further decreased by inhibition of Fas ligand and granzyme B . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand expression in Alzheimer ' s disease . ^^^ The Fas / Fas ligand ( L ) signaling system has been implicated in the control of cell death and cell survival of T and B lymphocytes and in a variety of cell types under particular pathological conditions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Intracellular Fas ligand is elevated in T lymphocytes in severe aplastic anaemia . ^^^ To investigate the role of Fas ligand ( FasL ) in triggering progenitor cell death , we examined FasL levels in T lymphocytes of patients with severe untreated AA ( n = 8 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These findings suggest that HSV has a comprehensive set of immune evasion functions that antagonize both Fas ligand and grB mediated pathways of CTL induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Up regulation of Fas ligand expression by human cytomegalovirus immediate early gene product 2 : a novel mechanism in cytomegalovirus induced apoptosis in human retina . ^^^ Here , we report that viral immediate early gene product 2 ( IE 2 ) , but not IE 1 , up regulates the Fas ligand ( FasL ) expression in HCMV infected human retinal pigment epithelium cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Regulation of Fas ligand expression by estradiol and progesterone in human endometrium . ^^^ Fas ligand ( FasL ) is one of the mediators of apoptosis in differentiated cells and in embryonic development . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this study , we examined the influence of maternal smoking on trophoblast apoptosis throughout development and correlated those findings with changes in expression of 10 linked inhibitor of apoptosis protein ( Xiap ) as well as Fas and Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Beta amyloid induces neuronal apoptosis via a mechanism that involves the c Jun N terminal kinase pathway and the induction of Fas ligand . ^^^ We found that in cortical neurons exposed to Abeta , activated c Jun N terminal kinase ( JNK ) is required for the phosphorylation and activation of the c Jun transcription factor , which in turn stimulates the transcription of several key target genes , including the death inducer Fas ligand . ^^^ The binding of Fas ligand to its receptor Fas then induces a cascade of events that lead to caspase activation and ultimately cell death . ^^^ By analyzing the effects of mutations in each of the components of the JNK c Jun Fas ligand Fas pathway , we demonstrate that this pathway plays a critical role in mediating Abeta induced death of cultured neurons . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of granzymes , Fas ligand , RANTES , prothymosin beta 4 , junB , RGS 1 , Btg 1 , and related molecules is high , whereas expression of conventional cytokines and high affinity cytokine receptors is low . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Induction of Fas ligand was associated with selenium induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RT PCR analysis revealed that HD eosinophils express mRNA for perforin , granzyme B and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We found that treatment of MDA MB 453 human breast cancer cells with adriamycin ( also known as doxorubicin , a DNA topoisomerase IIalpha inhibitor ) induced a series of time dependent events , including the mitochondrial release of cytochrome c and apoptosis inducing factor , mitochondrial membrane depolarization , activation of a set of caspases ( caspase 9 , 3 , 7 , 2 , and 8 ) , cleavage of poly ( ADP ribose ) polymerase ( PARP ) , and up regulation of expression of the Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Adenovirus mediated expression of HSV 1 TK or Fas ligand induces cell death in primary human glioma derived cell cultures that are resistant to the chemotherapeutic agent CCNU . ^^^ Expression of murine Fas ligand ( RAdhCMV mFasL ) also induced cell death in four of the five cell cultures studied . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : In the current study , the expression of the apoptosis related molecules p 53 , Bax , Bcl 2 , Fas ( CD 95 ) , Fas Ligand and perforin was examined in 7 patients with a sarcoma of the pulmonary artery . ^^^ Finally , several lymphocytes could be stained with perforin , but none of the specimens showed a reactivity for Fas or Fas Ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here we studied whether intragraft expression of perforin , granzyme B , and Fas ligand correlates with long term clinical outcome of acute rejection episodes . ^^^ METHODS : Twenty two human renal biopsies were quantified for mRNA expression of perforin , granzyme B , Fas ligand , and Fas with reverse transcription polymerase chain reaction . ^^^ RESULTS : Only Fas ligand , but not perforin or granzyme B , showed significantly higher up regulation in seven samples with therapy resistant acute rejections versus eight samples with therapy sensitive acute rejection . ^^^ CONCLUSIONS : Fas ligand may be useful as an early marker of therapy resistant acute rejection . ^^^ Cells that express Fas ligand but not classical soluble cytotoxic molecules might influence clinical outcome of acute rejection episodes . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
One possibility is the unique capacity of E1A to sensitize cells to multiple NK cell killing mechanisms including perforin / granzyme , Fas ligand , tumor necrosis factor alpha and TRAIL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Effect of Fas and Fas ligand deficiency in resistance of C57BL / 6 mice to HSV 1 keratitis and chorioretinitis . ^^^ PURPOSE : To investigate the effect of Fas and Fas ligand ( FasL ) deficiency on the development of herpes stromal keratitis and on the von Szily model of herpes retinitis in C57BL / 6 mice , which are ordinarily resistant to development of both of these herpetic diseases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Receptors for tumor necrosis factor ( TNF ) and Fas ligand have been implicated as regulators of steady state hematopoiesis , and if overexpressed mediate bone marrow failure . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this study we characterized the expression of Fas and Fas ligand in different types of meningiomas and examined the effect of Fas ligation on the death of meningioma cells in culture . ^^^ All of the meningiomas examined expressed low levels of Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas , Fas ligand ( Fas L ) , ERK , MEK , Bcl 2 , Bax , N myc , c myc , pro caspase 2 and active caspase 3 was examined by immunohistochemistry in the cerebellum of six patients with sporadic CJD , three patients with olivopontocerebellar atrophy ( OPCA ) and six age matched controls . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Embryonic trophoblast and maternal decidua produce corticotropin releasing hormone ( CRH ) and express Fas ligand ( FasL ) , a proapoptotic cytokine . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activation through CD 40 ligation induces functional Fas ligand expression by Langerhans cells . ^^^ After primary expansion , the majority of T cells undergo Fas / Fas ligand ( FasL ) mediated apoptotic cell death , thereby suppressing their excessive expansion . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Defective Fas ligand mediated apoptosis predisposes to development of a chronic erosive arthritis subsequent to Mycoplasma pulmonis infection . ^^^ Antigen presenting cells derived from Fas mutant lpr mice ( lpr APC ) were transfected ex vivo with an adenovirus ( Ad ) vector to yield lpr APC expressing high levels of Fas ligand ( lpr APC AdFasL ) , which in turn were transferred intraperitoneally into M pulmonis infected B 6 gld / gld mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas ligand released by colon adenocarcinoma cells induces host lymphocyte apoptosis : an active mode of immune evasion in colon cancer . ^^^ Expression of membrane bound Fas ligand ( mFasL ) on colon cancer cells serves as a potential mechanism to inhibit host immune function by inducing apoptosis of host lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Our previous work showed that the ability of donor marrow to induce tolerance was dependent on the presence of CD 95 ligand ( Fas ligand ) on the donor cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activation induced cell death ( AICD ) is a regulatory mechanism eliminating excess activated T cells , mainly through a Fas / Fas ligand dependent mechanism . ^^^ Expression of Fas receptor and Fas ligand by anti CD 3 activated DO11 . 10 cells was not affected by PGE ( 2 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Non apoptotic signaling pathways activated by soluble Fas ligand in serum starved human fibroblasts . ^^^ In the normal human diploid cell line GM 6112 , the addition of soluble Fas ligand ( sFasL ) leads to morphological signs of cell death in less than 1 % of cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Three novel findings are reported : ( a ) SCCs were found to be significantly more sensitive to induction of apo ptosis by SDG than normal human oral mucosa cells , though the differences were marginal with p XSC ; ( b ) both SE compounds induced the expression of Fas ligand ( Fas L ) in oral cells to a degree that correlated with the extent of apoptosis induction ; and ( c ) both SDG and p XSC induced the stress pathway kinases , Jun NH 2 terminal kinase ( JNK ) and p 38 kinase , at concentrations causing apoptosis ; p XSC , and to a lesser extent SDG , also activated extracellular regulated kinases 1 & 2 ( ERKs 1 & 2 ) and protein kinase B or Akt . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recently Fas Fas ligand system mediated apoptosis has been frequently reported in many epithelial cells as well as in T lymphocytes . ^^^ Fas , Fas ligand , and an intracellular adaptor protein , Fas associating protein with death domain ( FADD ) expression , and poly ADP ribose polymerase ( PARP ) cleavage were also studied . ^^^ CsA induced apoptosis in cultured tubular epithelial cells demonstrated by increased number of TUNEL positive cells and it was accompanied by a significant increase in Fas mRNA and Fas ligand protein expressions . ^^^ In alpha MSH co treated cells , apoptosis markedly decreased with downregulation of Fas , Fas ligand and FADD expressions and also the cleavage product of PARP . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To better understand the potential involvement of Fas system in non small cell lung cancer ( NSCLC ) we evaluated Fas and Fas ligand mRNA expression by polymerase chain reaction in 102 tumor samples and in 44 normal surrounding tissues . ^^^ Taken together , these findings point to an involvement of Fas / Fas ligand system in the development of NSCLC , suggesting that the loss of its apoptotic function might be linked to p 53 alterations which contribute to the self maintenance of cancer cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Mechanistically , the loss of T cell function is associated with an increased frequency of circulating monocytes , their expression of Fas ligand ( FasL ) , and a high frequency of apoptotic CD4+ T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The objective of this study was to assess the utility of measurement of thrombomodulin , antinucleosome antibodies , sVCAM 1 , sICAM 1 , neopterin , fas ligand , IL 10 and sIL 2R in patients with systemic lupus erythematosus ( SLE ) and to compare them with traditional markers of SLE activity ( anti dsDNA antibodies , C 3 , C 4 ) and the ECLAM index of disease activity . ^^^ Anti dsDNA antibodies , thrombomodulin , antinucleosome antibodies , sVCAM 1m sICAM 1 , neopterin , fas ligand , IL 10 and sIL 2R were tested by ELISA technique , while C 3 , C 4 components of complement were tested by nephelometry . ^^^ Fas ligand and IL 10 did not correlate with the ECLAM index . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand is unlikely to play a role in the immune evasion of breast cancer . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ag specific lytic capability is rapidly recovered if purified TIL are briefly cultured in vitro and tumor lysis is perforin , but not Fas ligand mediated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Induction of Fas and Fas ligand expression on malignant glioma cells by Kupffer cells , a potential pathway of antiliver metastases . ^^^ Both Kupffer cells and LPS / Kupffer cell conditioned supernatants induced expression of Fas and Fas ligand on malignant glioma cells . ^^^ Therefore , this study supports a novel pathway of Kupffer cells against liver metastases , in which tumor cells were apoptotic via the Fas Fas ligand system induced by TNFalpha released from Kupffer cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
MRL mice bearing the lpr ( Fas ) or gld ( Fas ligand ) mutation , MRL Fas ( lpr ) or MRL FasL ( gld ) , respectively , develop arthritis similar to rheumatoid arthritis , but C3H and C57BL / 6 mice bearing such mutations do not . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and fas ligand in human hepatocellular carcinoma . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We report that the bile ducts in PBC liver tissue frequently express increased levels of Fas , Fas ligand ( FasL ) , and CD 40 associated with apoptotic BEC . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The lethal hit is given to keratinocytes by means of Fas ligand expressed on the T cell surface or released to the inflammatory microenvironment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We demonstrate that in these cells , the activation induced cell death ( AICD ) is mediated by Fas and Fas ligand ( FasL ) interaction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand by microglia : possible role in glioma immune evasion . ^^^ Because the Fas pathway has been proposed to play a role in immune evasion , we examined the effect of tumor environment on the expression of Fas ligand ( FasL ) in a mouse glioma model . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Castration induces apoptosis in the male accessory sex organs of Fas deficient lpr and Fas ligand deficient gld mutant mice . ^^^ The role of the Fas ligand Fas system in castration induced apoptosis in the epithelia of the ventral prostate ( VP ) , seminal vesicle ( SV ) , coagulating gland ( CG ) and epididymis ( Ep ) was investigated using lpr / lpr , and gld / gld mutant mice which are deficient in Fas and Fas ligand , respectively . ^^^ The present results suggest that the Fas ligand Fas system plays little role in castration induced apoptosis in the mouse male accessory sex organs such as the VP , SV , CG and Ep . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apicidin , a histone deacetylase inhibitor , induces apoptosis and Fas / Fas ligand expression in human acute promyelocytic leukemia cells . ^^^ Consistent with these results , apicidin transiently increased the expressions of both Fas and Fas ligand . ^^^ Preincubation with NOK 1 monoclonal antibody , which prevents the Fas Fas ligand interaction and is inhibitory to Fas signaling , interfered with apicidin induced translocation of Bax , cytochrome c release , cleavage of procaspase 3 , and DNA fragmentation . ^^^ Taken together , the results suggest that apicidin might induce apoptosis through selective induction of Fas / Fas ligand , resulting in the release of cytochrome c from the mitochondria to the cytosol and subsequent activation of caspase 9 and caspase 3 . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , these cells produce Fas ligand , perforin , and granzyme B , the effector molecules required for killing . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , analysis of the molecular and cellular mechanisms involved in tumor clearance revealed that perforin , TNF alpha , Fas ligand , MHC class 1 , and CD 8 ( + ) T cells did not play a crucial role in tumor eradication . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
IL 18 binding protein protects against lipopolysaccharide induced lethality and prevents the development of Fas / Fas ligand mediated models of liver disease in mice . ^^^ Given 10 min before LPS challenge to mice primed 12 days in advance with heat killed Propionibacterium acnes , IL 18BP Fc prevents LPS induced liver damage and IFN gamma and Fas ligand expression . ^^^ IL 18BP Fc also prevents Con A induced liver damage and IFN gamma and Fas ligand expression as well as liver damage induced by Pseudomonas aeruginosa exotoxin A or by anti Fas agonistic Ab . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition to IFN gamma and soluble Fas ligand ( sFasL ) , IL 18 levels significantly correlated with disease activity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recently , we reported that HBx induces Fas Ligand ( FasL ) expression , which may help HCC cells to evade host immune surveillance . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A large spring wire was inserted into the femoral artery of C3H / HeJ ( wild type ) , C3H gld ( Fas ligand / ) , and C3H lpr ( Fas / ) mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Assignment of the feline Fas ligand gene ( TNFSF 6 ) to chromosome F1q12 > q 13 by fluorescence in situ hybridization . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis was induced by the chemotherapeutic agent camptothecin and by Fas ligand , then quantified by staining with fluorescein isothiocyanate conjugated annexin 5 and propidium iodide . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We cloned the Fas ligand ( FasL ) promoter and coupled it to the luciferase gene . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Inhibition of neointimal hyperplasia may also be achieved by gene transfer of endothelial NO synthase ( eNOS ) , PGI synthase , or cell cycle regulators ( retinoblastoma , cyclin or cyclin dependent kinase inhibitors , p 53 , growth arrest homeobox gene , fas ligand ) or antisense oligonucleotides to c myb , c myc , proliferating cell nuclear antigen , and transcription factors such as nuclear factor kappaB and E2F . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Estrogen receptor mediated , nitric oxide dependent modulation of the immunologic barrier function of the endothelium : regulation of fas ligand expression by estradiol . ^^^ Recently , Fas ligand ( FasL ) expression by the vascular endothelium has been shown to inhibit the migration of inflammatory cells into the vessel wall , an event that is considered crucial for the development of atherosclerosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These studies show : 1 ) differentiated CTL deliver Fas ligand and perforin dependent lethal hit equally well at all redox conditions ; 2 ) CTL development is delayed at 2 . 5 % oxygen as compared with 20 % oxygen . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand engagement of resident peritoneal macrophages in vivo induces apoptosis and the production of neutrophil chemotactic factors . ^^^ Fas ligand ( FasL ) is a potent proapoptotic type 2 transmembrane protein that can cause cell death in Fas+ target populations . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ag stimulation of CD8+ lymphocytes in vivo results in their migration to various tissues as well as the activation of a cytolytic program involving perforin , TNF alpha , and Fas ligand . ^^^ This was supported by findings of similar high levels of message for perforin , TNF alpha , and Fas ligand in liver lymphocytes from both mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression and regulation of Fas and Fas ligand on thyrocytes and infiltrating cells during induction and resolution of granulomatous experimental autoimmune thyroiditis . ^^^ Depletion of CD8+ cells delays resolution and reduces Fas ligand ( FasL ) mRNA expression in thyroids . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Inhibition of drug induced Fas ligand transcription and apoptosis by Bcl XL . ^^^ Fas / Fas ligand system triggers apoptosis in many cell types . ^^^ Bcl XL overexpresion antagonizes Fas / Fas ligand mediated cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Even though exercise did not alter the intracellular cytokines ( TNF alpha and interleukin 2 ) or Fas ligand , it did significantly lower interferon gamma in CD4+ and CD8+ cells ( P < 0 . 05 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Study on the expression of Fas ligand on the surfaces of human cytotrophoblasts in normal pregnancy ] . ^^^ Immunohistochemistry was used to investigate the expression of Fas Ligand ( FasL ) on the surfaces of human cytotrophoblasts . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Previous data indicated that IL 10 induces Fas ligand ( L ) expression on mouse T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunohistochemical analysis of apoptosis related factors ( Fas , Fas ligand , caspase 3 and single stranded DNA ) in ameloblastomas . ^^^ BACKGROUND : To clarify the possible role of apoptotic cell death in oncogenesis and cytodifferentiation of odontogenic epithelium , apoptosis related factors Fas , Fas ligand ( FasL ) , caspase 3 and single stranded DNA ( ssDNA ) were analyzed in ameloblastomas as well as in tooth germs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand expression in maternal blood and in umbilical cord blood in preeclampsia . ^^^ The Fas Fas ligand ( FasL ) pathway of apoptosis is abnormally activated in diseases associated with impaired immune tolerance or chronic inflammation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : The purpose of the present study was to investigate transcripts of perforin , granzyme B , and Fas ligand ( FasL ) in heart transplants undergoing rejection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND & AIMS : Acute liver failure ( ALF ) of viral origin results from massive hepatocyte apoptosis induced by the interaction between Fas expressed on hepatocytes and Fas ligand on activated T lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas receptor and Fas ligand expression was analyzed by RT PCR , flow cytometry , and immunoblotting . ^^^ In contrast , spontaneous apoptosis of neutrophils or eosinophils is unlikely to be the consequence of Fas ligand / Fas receptor molecular interactions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Thus , the investigated RRMs induce a death pathway , which is independent of Fas ligand , that is also activated by UV radiation and other agents . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
PATIENTS AND METHODS : Immunohistochemical stainings for CD 8 , granzyme B ( GrB ) , T cell restricted intracellular antigen ( TIA 1 ) , Fas ligand ( FasL ) , and killer cell inhibitory receptors ( KIRs ; CD 95 , CD158a , and CD158b ) were performed on 83 first diagnostic biopsy samples obtained from patients with plaque stage MF ( n = 42 ) , tumor stage MF ( n = 20 ) , and CD 30 PCLTCL ( n = 21 ) . ^^^ CD8+ T cells in cutaneous T cell lymphoma : expression of cytotoxic proteins , Fas Ligand , and killing inhibitory receptors and their relationship with clinical behavior . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The role of Fas ligand in immune privilege . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The mechanism by which NO causes apoptosis is unknown ; however , Fas ( CD 95 ) and Fas ligand ( FasL ) ( CD95L ) have been implicated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Differential secretion of Fas ligand or APO 2 ligand / TNF related apoptosis inducing ligand carrying microvesicles during activation induced death of human T cells . ^^^ Preformed Fas ligand ( FasL ) and APO 2 ligand ( APO2L ) / TNF related apoptosis inducing ligand ( TRAIL ) are stored in the cytoplasm of the human Jurkat T cell line and of normal human T cell blasts . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The authors found that expression of Fas and Fas ligand messenger ribonucleic acid and protein was induced in vulnerable CA 1 neurons at 24 and 72 hours after global ischemia . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased expression of pro apoptotic genes ( Fas , Fas ligand , caspase 1 and 3 ) and activated caspases in ischemic rat kidneys were decreased after CsA or FK 506 pretreatment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In murine T cells , membrane bound CD95L ( Fas ligand ) also acts as a costimulatory receptor to coordinate activation and function in vivo . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Defective Fas ligand production in lymphocytes from MS patients . ^^^ In the present transectional study , Fas ligand ( Fas L ) levels , either in membrane or in soluble form , in cells from multiple sclerosis ( MS ) patients were investigated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Transgenic mice ubiquitously expressing human Fas ligand develop a slight form of graft versus host like disease . ^^^ AIM : To construct transgenic mice bearing human Fas ligand ( FasL / CD95L ) cDNA , and further explore the physiological effects of ubiquitous expression of FasL on such animals . ^^^ CONCLUSION : Ubiquitous expression of Fas ligand can lead to slight GVH like disease . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand upregulation and apoptosis of bile duct epithelia have been demonstrated in human specimens , as well as T lymphocyte and macrophage activation in portal tracts . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand and sFas ligand in human gastric adenocarcinomas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ( CD 95 ) and Fas ligand ( Fas L ) , and significant DNA fragmentation were observed in the cells that died . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand ( FasL ) by the human trophoblast has been recently accepted as a mechanism providing protection against the lytic action of activated decidual immune cells expressing Fas receptor ( FasR ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Extracellular matrix dependent regulation of Fas ligand expression in human endometrial stromal cells . ^^^ We hypothesized that adhesion of endometrial stromal cells to the extracellular matrix could suppress the immunologic reaction to implanting endometrial cells by inducing the expression of Fas ligand ( FasL ) , a mediator of the apoptotic pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although Fas ligand expression is increased in the liver , it appeared to play no significant role in outcome , since mice expressing a mutant form of Fas ligand are still sensitive to LPS and D galactosamine induced lethality . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
By contrast , the expression of Fas and Fas ligand proteins was unchanged in most samples . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Differential inducibility of the transcriptional repressor ICER and its role in modulation of Fas ligand expression in T and NK lymphocytes . ^^^ The engagement of antigen receptor can initiate apoptosis of T lymphocytes through the induced expression of Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Binding of Fas ligand to Fas induces apoptosis . ^^^ The Fas Fas ligand system plays important roles in many biological processes , including the elimination of autoreactive lymphoid cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
M 50054 , 2 , 2 ' methylenebis ( 1 , 3 cyclohexanedione ) , was identified as a novel inhibitor of apoptosis ( programmed cell death ) using an in vitro cell death assay system induced in human Fas expressing WC 8 cells by soluble human Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Okadaic acid stimulates apoptosis through expression of Fas receptor and Fas ligand in human oral squamous carcinoma cells . ^^^ Binding of Fas ligand to Fas receptor leads to activation of the latter and the induction of intracellular signals that result in apoptotic cell death . ^^^ In the present study , we used reverse transcriptase polymerase chain reaction ( RT PCR ) and Western blot analysis to examine the expression of mRNAs and proteins of Fas receptor and Fas ligand in human oral squamous carcinoma SCC 25 cells treated with okadaic acid . ^^^ Fas ligand mRNA expression was also stimulated by okadaic acid in SCC 25 cells in dose and time dependent manners . ^^^ Okadaic acid also stimulated the expression of Fas ligand protein in the cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Suppression of Akt signaling induces Fas ligand expression : involvement of caspase and Jun kinase activation in Akt mediated Fas ligand regulation . ^^^ Fas and Fas ligand ( FasL ) expression has been detected in chronic vascular lesions , and Fas mediated apoptosis of vascular smooth muscle cells ( VSMC ) may influence the integrity of the atherosclerotic plaque . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Effects of Fas ligand expression on pancreatic islet allografts ] . ^^^ OBJECTIVE : To investigate the immune privilege of islet allgrafts induced by the Fas ligand ( FasL ) expressed by co transplanted testicular Sertoli cells and the effects of FasL gene transfected into islet cells on pancreatic islet allografts . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Role of fas ligand in uveal melanoma induced liver damage . ^^^ We hypothesized that uveal melanoma cells might express Fas ligand ( FasL ) , facilitating FasL mediated apoptosis of Fas expressing hepatocytes . ^^^ PURPOSE : To determine whether Fas ligand ( FasL ) expressing human uveal melanoma cells induce apoptosis of human hepatocytes in vitro and in vivo . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We have also analyzed cellular Fas and Fas ligand expression in these cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of fas ligand in metastatic prostatic carcinoma : suggestive of possible clonal expansion of subpopulation with metastatic potential . ^^^ Fas ligand ( FasL ) is a type 2 transmembrane tumor necrosis factor family protein , known to trigger apoptosis in cells that bear the FasL receptor , Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthemore , UVB irradiation did not affect the basal expression of Fas ligand mRNA , protein and soluble Fas ligand . ^^^ These results indicate that UVB irradiation induces multimerization of Fas antigen that results in apoptosis without the Fas ligand . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Modulation of experimental allergic encephalomyelitis in Lewis rats by administration of a peptide of Fas ligand . ^^^ The effects of modulation of apoptosis in experimental allergic encephalomyelitis ( EAE ) in Lewis rats have been investigated using a peptide of the Fas Ligand protein ( FasL p ) . ^^^ The data suggest that the Fas / Fas ligand pathway may be modulated by treatments with peptides of Fas Ligand and that it may be at work within the central nervous system in EAE . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In particular , synthetic MMPIs may directly induce apoptosis of cancer cells via their inhibitory effect on the shedding of Fas Ligand ( FasL ) , a transmembrane member of the TNF superfamily that kills susceptible cells through its receptor , Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Importantly , TRAIL / Apo2L induced apoptosis was unaffected by IL 6 , a potent growth and survival factor for MM cells which , as we and others have previously shown , blocks various pro apoptotic signals including Fas ligand , which like TRAIL / Apo2L is also a member of the TNF family of ligands . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the human HBL 100 and murine NMuMG cell lines that represent early stages of tumor progression and that express both Fas ligand and its receptor , exposure to matrilysin results in cell death that can be blocked by FasL neutralizing antibodies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
And , we recently reported that TRAIL is constitutively expressed on a substantial proportion of murine NK cells in the liver , and which is responsible for spontaneous cytotoxicity and the anti metastatic activity against TRAIL sensitive tumor cells along with perforin and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Factors influencing the expression of Fas and Fas ligand on newborn murine keratinocytes and fibroblasts . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Oral administration of insulin to female nonobese diabetic mice inhibited diabetes and induced Fas ligand expression on islets of Langerhans . ^^^ OBJECTIVE : To detect oral administration of recombinant human insulin to nonobese diabetic ( NOD ) mice for preventing them from diabetes and insulitis and to detect the effects of oral administration of insulin on Fas and Fas ligand expression on islet of Langerhans . ^^^ We examined Fas ligand and Fas expression on islets of Langerhans in both groups of NOD mice by using immunohistochemical techniques . ^^^ We find that Fas only expressed on islets when the mice suffered the diabetes , whereas Fas ligand expressed on islets of the mice fed with insulin at 16 and 20 week of ages . ^^^ We did not find Fas ligand positive staining on the islet feeding with PBS . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Concentrations of IL 2 induced IL 10 and soluble Fas ligand ( sFasL ) were not affected by IL 1beta . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recent data suggest a role for Fas ( APO 1 , CD 95 ) , a type 1 transmembrane receptor glycoprotein of the nerve growth factor / tumor necrosis factor superfamily , and its ligand ( Fas ligand , FasL ) in apoptotic events in the central nervous system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Actin cytoskeleton is required for early apoptosis signaling induced by anti Fas antibody but not Fas ligand in murine B lymphoma A 20 cells . ^^^ Murine B lymphoma A 20 cells are highly sensitive to Fas mediated death signals induced by anti Fas antibody Jo 2 or cross linked Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Enhancement of Fas ligand induced inhibition of neointimal formation in rabbit femoral and iliac arteries by coexpression of p 35 . ^^^ Adenovirus mediated gene transfer of Fas ligand ( FasL ) inhibits neointimal formation in balloon injured rat carotid arteries . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : Involvement of tumor necrosis factor ( TNF ) alpha and Fas signaling was evaluated using various knockout mice ( TNF receptor 1 [ TNF R 1 ] / , Fas [ lpr ] / , and Fas ligand [ gld ] / ) and wild type mice pretreated with pentoxifylline , an inhibitor of TNF alpha synthesis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation : selective regulation of mitogen activated protein kinase activation and fas ligand expression . ^^^ Unexpectedly , TCR stimulated activation of the Fas ligand ( FasL ) promoter and subsequent cell death was dependent upon superoxide anion , but independent of hydrogen peroxide , while nuclear factor of activated T cells ( NFAT ) activation or interleukin 2 transcription was independent of all ROS . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activated T cells in these patients failed to express Fas ligand ( FasL ) in response to IL 2 , which may explain the accumulation of T cells with an activated phenotype and a skewed T cell receptor ( TcR ) Vbeta family distribution . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Induction of the cellular apoptotic cascade occurs via interaction between two membrane receptors : Fas and Fas ligand . ^^^ We aimed to document the temporal profile of soluble Fas and soluble Fas ligand after cardiopulmonary bypass and to investigate whether steroid pretreatment alters this response . ^^^ Soluble Fas , soluble Fas ligand , and interleukin 6 were measured from induction of anesthesia until 24 hours after admission to the intensive care unit . ^^^ Conversely , soluble Fas ligand release was unchanged by cardiopulmonary bypass and steroid administration . ^^^ However , patients with higher soluble Fas ligand levels exhibited a more dramatic drop and delayed recovery in monocyte count , consistent with the role of this molecule in apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Western blot analysis showed that butyrate increased Fas and Fas ligand levels ( Fas L ) , indicating that butyrate induced apoptosis may be mediated by Fas signalling . 5 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Secretory phospholipase A ( 2 ) elicits proinflammatory changes and upregulates the surface expression of fas ligand in monocytic cells : potential relevance for atherogenesis . ^^^ This was accompanied by activation of arachidonate metabolism , as judged from both the activation of the cytosolic phospholipase A ( 2 ) ( cPLA ( 2 ) ) and the induction of cyclooxygenase 2 ( COX 2 ) expression . sPLA ( 2 ) also elicited the production of monocyte chemoattractant protein 1 ( MCP 1 ) and showed a synergistic effect with TNF alpha on both COX 2 induction and MCP 1 production . sPLA ( 2 ) upregulated the expression of Fas ligand at the cell surface , but it did not influence Fas expression nor cell survival of monocytes . ^^^ In summary , these data indicate that some of the atherogenic effects of sPLA ( 2 ) can be exerted by engagement of an sPLA ( 2 ) binding structure on monocytic cells , most probably the M type receptor for sPLA ( 2 ) , which produces the activation of the MAPK cascade , induces a proinflammatory phenotype , and upregulates the cell surface expression of Fas ligand . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas and Fas ligand in esophageal tissue mucosa and carcinomas . ^^^ The Fas ligand ( FasL ) and its receptor Fas play a key role in the initiation of an apoptotic pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Corticotropin releasing hormone induces Fas ligand production and apoptosis in PC 12 cells via activation of p 38 mitogen activated protein kinase . ^^^ The aim of the present work was to examine the effect of CRH on apoptosis and the Fas / Fas ligand system in an in vitro model , the PC 12 rat pheochromocytoma cell line , which is widely used in the study of apoptosis and at the same time expresses the CRH / CRH receptor system . ^^^ CRH induced Fas ligand production and apoptosis . ^^^ These effects were mediated by the CRH type 1 receptor because its antagonist antalarmin blocked CRH induced apoptosis and Fas ligand expression . ^^^ CRH activated p 38 mitogen activated protein kinase , which was found to be essential for CRH induced apoptosis and Fas ligand production . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand in autoimmunity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This then leads to the speculation that apoptosis defects , including defects in Fas , Fas ligand and Fas apoptosis signaling , may play a role in defective downmodulation of the hyperimmune response observed in human autoimmune diseases . ^^^ Over the past 7 years , many scientists have analyzed different proapoptotic genes such as Fas , Fas ligand , Bcl 10 , caspases as well as antiapoptosis pathways including defects in Fas and Fas ligand , Bcl 2 and caspase inhibitors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast to Bcl 2 , both Fas and Fas ligand in glandular cells were coexpressed throughout the menstrual cycle . ^^^ In particular , glandular cells showed the most intense expression of Fas ligand from the secretory to menstruating phases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expressing B 1a lymphocytes mediate CD 4 ( + ) T cell apoptosis during schistosomal infection : induction by interleukin 4 ( IL 4 ) and IL 10 . ^^^ A previous study of the murine model of Schistosoma mansoni infection has implicated splenic CD 19 ( + ) B lymphocytes as Fas ligand ( FasL ) bearing mediators of CD 4 ( + ) T lymphocyte apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Death associated protein kinase ( DAP Kinase ) is a pro apoptotic serine / threonine kinase with a death domain , which is involved in apoptosis induced by interferon gamma , tumor necrosis factor alpha , and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVE : To analyse the expression of Fas and Fas ligand ( FasL ) in patients of chronic hepatitis , liver cirrhosis and hepatocellular carcinoma and to study the regulation of apotosis by Bax and Bcl 2 subfamilies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of Fas and Fas ligand ( FasL ) was examined by immunofluorescent staining and flow cytometer analysis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Our recent work has shown that primary cultures of oral carcinoma biopsies are significantly more sensitive than normal oral mucosa cultures to induction of apoptosis by a natural selenium metabolite [ selenodiglutathione ( SDG ) ] , and this is associated with induction of Fas ligand , a well known mediator of apoptosis in other contexts , and activation of so called stress kinase signaling pathways , particularly the Jun NH 2 terminal kinase ( JNK ) . ^^^ In contrast , although the potent pharmacological selenium chemopreventive agent 1 , 4 phenylenebis ( methylene ) selenocyanate ( p XSC ) also induces Fas ligand , heme oxygenase , and stress kinase pathways , apoptosis / Fas induction is not so strongly JNK dependent and p XSC does not show tumor selectivity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Western blot analyses with specific antibodies demonstrated that both p 53 and Fas ligand were endogenously expressed in SKN SH cells , but their expression was not stimulated by doxorubicin . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptotic markers such as the soluble fas ligand are also elevated in inflammation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Findings from in vitro culture studies and analysis of mononuclear cells in the peripheral blood of HIV infected patients have led to the hypothesis that abnormal expression and / or interaction of Fas and Fas ligand ( FasL ) may play significant roles in the derangement of homeostasis of CD 4 ( + ) lymphocytes in patients infected with HIV 1 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Inhibition of lens epithelial cells by Fas specific antibody activating Fas Fas ligand system . ^^^ PURPOSE : To detect cell specific apoptosis factors , Fas and Fas ligand , and the common intracellular apoptosis modulators , interleukin 1 beta converting enzyme ( ICE ) like protease ( caspase 1 ) , Bcl 2 , Bcl xL and Bax in lens epithelial cells ( LEC ) of human cataracts . ^^^ METHODS : Reverse transcriptase polymerase chain reaction ( RT PCR ) was used to detect Fas , Fas ligand , caspase 1 , Bcl 2 , Bcl xL and Bax , after cDNA was synthesized from the total RNA isolated from human cataractous LEC obtained by capsulotomy during cataract surgery . ^^^ Fas ligand mRNA was not detected by RT PCR . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expressions of Fas , Fas ligand , and Bcl 2 were examined by semiquantitative RT PCR and immunohistochemistry . ^^^ Meanwhile , the Fas ligand was also low until day 3 , but showed a remarkable increase from days 5 to 7 , followed by a gradual decrease . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of Fas ligand protein in ultraviolet exposed rabbit corneas . ^^^ It was reported that the Fas / Fas ligand system is involved in modulating keratocyte apoptosis . ^^^ The expression of Fas ligand ( FasL ) protein was studied in rabbit corneas after photokeratitis induced by different UV wavelengths . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( CD95 / Apo 1 ) / Fas ligand expression in neonates with pontosubicular neuron necrosis . ^^^ Here , we have investigated the expression of Fas / Fas ligand in human autopsy material consisting of 13 PSN cases and 10 age matched cases without PSN . ^^^ Terminal deoxynucleotidyl transferase mediated dUTP nick end labeling , immunohistochemistry , and double labeling for Fas / Fas ligand and the astrocyte marker glial fibrillary acid protein , the microglia / macrophage specific marker KiM1P , and the neuronal marker NeuN were performed on formalin fixed brain specimens . ^^^ In contrast , Fas ligand expression was found mainly on astrocytes and microglial cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Viral transfection of recipient immature dendritic cells encoding for immunosuppressive or apoptotic molecules , such as interleukin 10 , transforming growth factor beta , CTLA 4 Ig , or Fas ligand , is also able to induce hyporesponsiveness . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Dendritic cells transduced with viral interleukin 10 or Fas ligand : no evidence for induction of allotolerance in vivo . ^^^ We transduced bone marrow derived DC with recombinant MFG retrovirus encoding either viral interleukin ( vIL ) 10 or Fas ligand ( FasL ) to induce transplantation tolerance . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
More importantly , normal liver tissue appears not to be susceptible to the cytotoxic effects of TRAIL / Apo2L , although activation of the related Fas ligand receptor system is known to promote massive liver apoptosis terminating in fulminant hepatitis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : Human monocytic U 937 cells were suspended in a Gln free medium , exposed for 20 minutes to either tumor necrosis factor alpha , Fas ligand , heat shock , or UV irradiation and allowed to recover for 4 hours or 24 hours . ^^^ RESULTS : When induced by tumor necrosis factor alpha , Fas ligand , or heat shock , the apoptosis rate was significantly lower ( 50 % 60 % ) in the presence of Gln than in the absence of Gln ( P < . 02 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( CD95L ) was not detected in vitro by RT PCR . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
AIM : To investigate the correlation between lymphogenous metastasis and matrix metalloproteinases ( MMPs ) activity and the expression of Fas ligand of tumor cells in lymph nodes . ^^^ The expression of Fas ligand , PCNA , Bcl 2 protein of Hca F and Hca P cells in the mice were examined by immunohistochemistry . ^^^ The expression of Fas Ligand of Hca F cells was stronger than that of Hca P cells ( P < 0 . 01 ) . ^^^ The increased expression of Fas ligand protein of Hca F tumor cells with high lymphogenous metastatic potential in lymph nodes may help tumor cells escape from being killed by host lymphocytes . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Effect of liver transplantation on islet allografts : up regulation of Fas ligand and apoptosis of T lymphocytes are associated with islet graft tolerance . ^^^ The cellular infiltrate , and the extent of apoptosis and of Fas ligand ( FasL ) expression in the islet grafts were evaluated on days 2 , 4 , and 7 after transplantation by means of immunostaining and the in situ terminal deoxynucleotide transferase mediated dUTP nick end labeling assay . ^^^ Islet graft tolerance induced by liver transplantation is the result of an immune process that involves up regulation of Fas ligand expression on , and apoptosis of , islet graft infiltrating lymphocytes . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Downstream molecules of Akt , including NF kappaB , Fas ligand , and BAD were examined , among which phosphorylation of BAD by Axl Gas 6 signaling is associated with the anti apoptotic activity of Akt in our study . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression level of c FLIP versus Fas determines susceptibility to Fas ligand induced cell death in murine thymoma EL 4 cells . ^^^ The murine thymoma cell line EL 4 was resistant to Fas ligand ( FasL ) induced apoptosis by constitutive expression of FLIP ( L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Role of TNF , lymphotoxin alpha ( 1 ) beta ( 2 ) , Fas ligand , and TNF related apoptosis inducing ligand . ^^^ We determine that human immature DCs express on their cell surface four different cytotoxic TNF family ligands : TNF , lymphotoxin alpha ( 1 ) beta ( 2 ) , Fas ligand , and TNF related apoptosis inducing ligand ; while cancer cells express the corresponding death receptors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Reduction of DNA binding activity of consensus and potential AP 1 binding sites in mouse Fas ligand promoter sequence was observed in nuclear extracts from transgenic mice overexpressing intracellular glutathione peroxidase compared with normal animals following I / R . ^^^ Cultured primary neurons from the transgenic mice demonstrated protection against hypoxia / reoxygenation injury as well as cytotoxicity after TNF alpha and Fas ligand treatment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas activation by Fas ligand induced a hypertrophic response in cultured cardiomyocytes , which was dependent on the inactivation of glycogen synthase kinase 3 beta ( GSK 3 beta ) by phosphorylation . ^^^ In contrast , Fas ligand was dispensable for the development of pressure overload hypertrophy in vivo . ^^^ In vitro , neonatal cardiomyocytes from lpr mice showed a completely abrogated or significantly blunted hypertrophic response after stimulation with Fas ligand or angiotensin 2 , respectively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVE : Although well characterized in several solid tumors , the effects of Fas / Fas ligand interactions in malignant pleural mesothelioma cells have not been defined . ^^^ The present study was undertaken to examine the functional status of the Fas / Fas ligand pathway in malignant pleural mesothelioma cells and to determine the feasibility of targeting this death signal pathway for molecular intervention in patients with mesotheliomas . ^^^ Soluble Fas ligand mediated cytotoxicity and apoptosis were evaluated by means of MTS and TUNEL assays , respectively . ^^^ Cisplatin ( 3 microg / mL ) and lymphokine activated killer cells were used to enhance mesothelioma sensitivity to soluble Fas ligand . ^^^ An H 2373 nude mouse xenograft model of malignant pleural mesothelioma was established to assess the in vivo effects of soluble Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
After gene transfer , Fas expression , cytokine production , and sensitivity to Fas ligand ( FasL ) mediated death were assessed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The SABC method was used to label the expression of Fas ligand in co transplantation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
By contrast , in lung and liver metastasis models , cytotoxic molecules expressed by NK cells and NKT cells ( perforin , Fas ligand , and tumor necrosis factor related apoptosis inducing ligand ) and an NKT cell secreted cytokine , IL 4 , were not necessary for the antitumor activity of alpha GalCer . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This study demonstrates that the abnormal up regulation of apoptogenic receptors , including both Fas ligand ( L ) and tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) , by highly malignant myeloma cells is involved in the pathogenesis of the ineffective erythropoiesis and chronic exhaustion of the erythroid matrix . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The death receptor ligands tumor necrosis factor ( TNF ) , Fas ligand ( FasL ) and TNF related apoptosis inducing ligand ( TRAIL ) are able to induce apoptosis by binding to their cell membrane receptors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand in urogenital malignant cell lines and renal cell carcinoma ] . ^^^ OBJECTIVE : To explore the expression of Fas ligand in urogenital malignant cell lines and renal cell carcinoma . ^^^ METHODS : With immunocytochemistry and reverse transcription polymerase chain reaction ( RT PCR ) , we detected the expression of Fas ligand ( FasL ) in 6 urogenital malignant cell lines , bladder carcinoma cell lines ( T ( 24 ) , EJ , BIU 87 ) , renal cell carcinoma cell lines ( GRC 1 , RCC 949 ) , prostatic carcinoma cell line ( PC 3M ) , and 10 cases of renal cell carcinoma . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand on peritumoral lymphocytes and its association with apoptosis of colorectal carcinomas ] . ^^^ OBJECTIVE : To study the expression of Fas ligand on peritumoral lymphocytes and its relation to the apoptosis of colorectal carcinoma . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
APAP , but not NCX 701 , upregulated liver Fas and Fas Ligand mRNA expression in vivo . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand in patients with evident skull base involvement of nasopharyngeal carcinoma . ^^^ We investigated whether skull base involvement in patients with nasopharyngeal carcinoma ( NPC ) is correlated with expression of Fas ligand ( FasL ) in NPC cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Complete mutation scan of the human Fas ligand gene : linkage studies in Type 1 diabetes mellitus families . ^^^ There is evidence that the apoptosis inducing T cell effector , Fas ligand ( FasL ) could be involved in the pathogenesis of Type 1 diabetes , probably because FasL mediated apoptosis is important in maintaining peripheral self tolerance and in down regulating an immune response . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas and Fas ligand in human gastric adenomas and intestinal type carcinomas : correlation with proliferation and apoptosis . ^^^ BACKGROUND : Fas ( APO 1 / CD95 ) , a member of the tumor necrosis factor / nerve growth factor receptor superfamily , mediates apoptosis in response to agonistic antibodies or Fas ligand ( FasL ) binding . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : Tissues from 30 RCC cases were immunostained for Fas and Fas ligand ( FasL ) to assess associations between Fas labeling status of RCC , indices of FasL positive tumor infiltrating mononuclear cells ( FasL TIM ) and apoptotic indices ( AI ) of RCC . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Co transduction of p27Kip1 strongly augments Fas ligand and caspase 8 mediated apoptosis in U 373MG glioma cells . ^^^ MATERIALS AND METHODS : In this study , we transduced U 373MG glioma cells with the Fas ligand or caspase 8 genes using adenovirus vectors after transduction of the p27Kip1 gene to induce cell cycle arrest in U 373MG cells , and evaluated the degree of apoptosis . ^^^ RESULTS : The results demonstrate that expression of p27Kip1 enhanced Fas ligand or caspase 8 mediated apoptosis in U 373MG cells . ^^^ Expression of apoptosis related genes such as Bax , Bcl 10 ( L ) , Bcl 2 or caspase 8 were reduced by p27Kip1 transduction compared with that of beta actin , whereas p27Kip1 transduction did not affect the expression level of Fas or the Fas ligand . ^^^ CONCLUSION : Combined transduction of p27Kip1 with Fas ligand or caspase 8 would overide the resistance mechanism to apoptosis in malignant gliomas . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased plasma levels of the soluble form of Fas ligand in patients with acute myocardial infarction and unstable angina pectoris . ^^^ OBJECTIVES : To examine whether the Fas / Fas ligand system is involved in the pathogenesis of acute myocardial infarction ( AMI ) , we measured the levels of the soluble form of the Fas ligand ( sFasL ) in the plasma of patients with AMI and stable or unstable angina pectoris ( AP ) . ^^^ BACKGROUND : The Fas ligand ( FasL ) is rapidly cleaved off by a metalloproteinase from the cell membrane to become a soluble form as a cytokine . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Physical training modulates proinflammatory cytokines and the soluble Fas / soluble Fas ligand system in patients with chronic heart failure . ^^^ OBJECTIVES : We sought to investigate the effects of physical training on circulating proinflammatory cytokines and the soluble apoptosis mediators Fas ( sFas ) and Fas ligand ( sFasL ) in patients with chronic heart failure ( CHF ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Upon CdCl ( 2 ) treatment , both Sertoli cells and the germ cells upregulated Fas ligand ; this event was also suppressed by zinc protoporphyrin 9 and restored by dichloromethane . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Specific proteins , including MMP 2 , MMP 9 , and Fas ligand ( FasL ) , were present on MFs from both endometrial and ovarian cancer sera . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Retinoids are potent immune modulators that inhibit Fas ligand ( FasL ) expression and thereby repress the activation induced apoptosis of immature thymocytes and T cell hybridomas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tissue specimens from 84 advanced gastric carcinoma patients who had undergone a curative resection were evaluated for host immune status ( CD8+ T cells ) , tumor stromal reaction ( AZAN staining ) , tumor Fas ligand expression and incidence of tumor cell apoptosis ( by TUNEL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , immunohistochemical analysis of the tumor tissue showed an increased expression of both Fas and Fas ligand after irradiation , suggesting that this cell death pathway might contribute to the overall PDT induced apoptotic response . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Defective Fas ligand expression and activation induced cell death in the absence of IL 2 inducible T cell kinase . ^^^ These studies show that Itk is required for maximal activation of early growth responses 2 and 3 and Fas ligand transcription after TCR stimulation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis coincided with overproduction of Fas ligand during the differentiation stage and was inhibited by Fas Fc chimeric protein . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Moreover , sHLA 1 or CD 8 cross linking with specific mAbs elicited intracellular calcium increases , Fas ligand ( FasL ) messenger RNA transcription , and FasL secretion , which were needed for delivering the death signal . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This interaction prevents Fas self aggregation and Fas ligand binding , thus inhibiting Fas activation and apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this study , we examined the in vitro effect of zinc on the apoptosis of mouse TS / A mammary adenocarcinoma cells , studying the zinc dependent modulation of the intracellular levels of reactive oxygen species ( ROS ) and of p 53 and Fas / Fas ligand pathways . ^^^ The apoptosis was associated with an increased production of intracellular ROS , and of p 53 and Fas / Fas ligand mRNA and protein . ^^^ The treatment of tumor cells with the antioxidant N acetylcysteine was able to prevent Zn ( 2+ ) induced apoptosis , as well as the increase of p 53 and Fas ligand protein induced by zinc . ^^^ The data demonstrate that zinc exerts a direct action on mammary cancer cells inducing ROS mediated apoptosis and that the effect may be mediated by the ROS dependent induction of p 53 and Fas / Fas ligand . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas Fas ligand system mediates luteal cell death in bovine corpus luteum . ^^^ Fas antigen ( Fas ) is a cell surface receptor that triggers apoptosis in sensitive cells when bound to the Fas ligand ( Fas L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Aspirin sensitive versus non aspirin sensitive nasal polyp patients : analysis of leukotrienes / Fas and Fas ligand expression . ^^^ Eosinophils were analyzed for Fas and Fas ligand receptors using flow cytometry . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Proteasome inhibitors block Ras / ERK signaling pathway resulting in the downregulation of Fas ligand expression during activation induced cell death in T cells . ^^^ Activation induced cell death ( AICD ) plays a critical role in the maintenance of homeostasis and peripheral tolerance in the immune system , and is mediated by Fas ligand ( FasL ) expression and the interaction between Fas and FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We have established quantitative real time PCR methods to determine the levels of mRNA transcripts for the CL genes granzyme B ( GB ) , perforin , and fas ligand in blood samples from rhesus and cynomolgus monkeys . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of TNF receptor 55 and TNF receptor associated death domain ( TRADD ) was increased , with no changes in Fas signaling molecules , Fas , Fas ligand ( FasL ) , Fas associated death domain ( FADD ) and Fas associated protein factor ( FAF ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand mRNA expression in the mouse central nervous system . ^^^ Fas ligand ( FasL ) expressing cells delete Fas bearing T cells , thereby enabling privileged immune status in the brain . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Identification of a polymorphic microsatellite marker in the mouse Fas ligand gene . ^^^ We describe the characterization of a polymorphic microsatellite marker , located 1 . 8 kb downstream of exon 4 in the mouse Fas ligand gene . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis of vascular smooth muscle cells is induced by Fas ligand derived from monocytes / macrophage . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
FB ( 1 ) treatment induced expression of Fas in liver and kidney with no alterations in Fas signaling molecules , Fas ligand , Fas associated death domain and Fas associated protein factor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECT : The goal of this study was to investigate whether apoptosis occurs in T lymphocytes that invade Fas ligand ( FasL ) expressing glioblastomas multiforme ( GBMs ) and if its induction could be mediated by Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand is up regulated during the colorectal adenoma carcinoma sequence . ^^^ AIMS : Fas ligand ( FasL ) expression by cancer cells may mediate tumour immune privilege . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Lack of both Fas ligand and perforin protects from flavivirus mediated encephalitis in mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Effect of iodide on Fas , Fas ligand and Bcl w mRNA expression in thyroid of NOD mice pretreated with methimazole . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The effects of GnRHa on the number of viable cells , expression of proliferating cell nuclear antigen ( PCNA ) , Fas and Fas ligand , and apoptosis in cultured leiomyoma cells were examined by MTT ( 3 ( 4 , 5 dimethylthiazol 2 yl ) 2 , 5 diphenyl tetrasodium bromide ) assay , immunocytochemical analysis , Western blot analysis and TUNEL assay respectively . ^^^ GnRHa markedly increased the expression of Fas and induced the expression of Fas ligand in the cultured leiomyoma cells on the basis of Western blot analysis . ^^^ These direct effects of GnRHa on the number of viable cultured leiomyoma cells , PCNA positive rate , apoptosis positive rate and Fas / Fas ligand expression in the cultured leiomyoma cells were only attained after the 4 day treatment . ^^^ CONCLUSIONS : The present results demonstrate that GnRHa directly inhibits the growth of human uterine leiomyoma cells by suppressing cell proliferation and inducing apoptosis , which might be associated with the increase in Fas expression and the induction of Fas ligand expression in the cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cellular localization and function of Fas ligand ( CD95L ) in tumors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , apoptosis induced by TNF alpha , IFN gamma , and Fas ligand was markedly reduced by desamino ( 1 3 ) IGF 1 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : Archival tissue from six chronic pancreatitis cases was compared with six normal controls using TUNEL and immunohistochemistry for CD 3 , CD 20 , CD 68 , MIB 1 , Bcl 2 , Bax , Fas , Fas ligand , retinoblastoma protein ( Rb ) , and tissue inhibitor of metalloproteinases 1 ( TIMP 1 ) and 2 ( TIMP 2 ) . ^^^ Islet Fas and Fas ligand expression exceeded acinar expression in chronic pancreatitis and controls . ^^^ Fas ligand expression may be restricted to islet cell membranes through TIMP 1 expression and inhibit islet damage by promoting apoptosis of cytotoxic T lymphocytes . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
IL 18 induces gene expression and synthesis of tumour necrosis factor ( TNF ) , IL 1 , Fas ligand , several chemokines , and vascular adhesion molecules . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Nitric oxide mediates apoptosis through formation of peroxynitrite and Fas / Fas ligand interactions in experimental autoimmune uveitis . ^^^ However , inhibition of NOS by N ( G ) nitro L arginine methyl ester was accompanied by a sparing of CD 3 ( + ) and CD 2 ( + ) T cells despite continued expression of Fas and Fas ligand , thus compromising functional inactivation of T cells in the target tissue . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( Apo 1 / CD95 ) and Fas ligand interaction between gastric cancer cells and immune cells . ^^^ BACKGROUND AND AIMS : It has been proposed that the expression of Fas ligand ( Fas L ) in tumors may play an important role in immune escape . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , other proteins analyzed [ namely , Apaf 1 , Bax , Bid , caspase 3 , caspase 8 , caspase 9 , 10 linked inhibitor of apoptosis protein ( XIAP ) , cellular inhibitor of apoptosis protein ( cIAP ) 1 , cIAP 2 , cytochrome c , Fas , Fas ligand , FLIP , p 53 , and poly ( ADP ribose ) polymerase ] were not affected by either rituximab or cisplatin . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of thymidylate synthase ( TS ) , p 53 , retinoblastoma protein ( Rb ) , Fas receptor , Fas ligand , bcl 2 , mcl 1 , bax , and bcl 10 was measured using immunohistochemistry . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased circulating levels of soluble Fas ligand are correlated with disease activity in patients with fibrosing lung diseases . ^^^ OBJECTIVE : The Fas Fas ligand ( FasL ) pathway is one of the important apoptosis signalling molecule systems . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased Fas promoter activity was paralleled by enhanced susceptibility of PIC + cytokine treated beta cells to apoptosis induced by Fas ligand . beta Cell infection with the NF kappa B inhibitor AdI kappa B ( ( SA ) 2 ) prevented both necrosis and apoptosis induced by PIC + IL 1 beta or PIC + IFN gamma . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Human CD34+ cells from CB or PBSC were cultured in serum free medium , with or without hematopoietic growth factors ( FKT : FLT 3 ligand [ FL ] , KIT ligand [ KL ] , and thrombopoietin [ TPO ] ) , and with or without soluble Fas ligand ( sFasL ) or agonistic anti Fas antibody . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The delivery of transgenes capable of interfering with antigenic recognition and / or cell death [ e . g . , Fas ligand ( FasL ) , Bcl 2 , Bcl XL ] as well as imparting tolerance / immunoregulation [ e . g . , interleukin ( IL ) 4 , IL 10 , transforming growth factor ( TGF ) beta ] , or cytoprotection [ e . g . , heme oxygenase 1 ( HO 1 ) , catalase , manganese superoxide dismutase ( MnSOD ) ] may prevent recurrent type 1 diabetes in islet transplantation and offer a promising form of immunotherapy . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunohistochemical demonstration of the expression of th following markers was performed on formalin fixed skin sections : Fas ( CD 95 ) , Fas ligand ( FasL ) bcl 2 , granzyme B , the tumour suppressor protein PTEN and the effector caspase , caspase 3 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased expression of fas ligand in human tuberculosis and leprosy lesions : a potential novel mechanism of immune evasion in mycobacterial infection . ^^^ Ag ) , Fas ligand ( FasL ) , Fas , CD 68 and Mac 387 by immunohistochemistry , and apoptotic cells by the terminal deoxynucleotidyl transferase mediated dUTP digoxigenin nick end labelling method . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Glomerular expression of Fas ligand and Bax mRNA in lupus nephritis . ^^^ The current studies were carried out to determine the expression of Fas ligand and Bax in kidneys from lupus nephritis as possible indicators of apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This may be because at lower doses of Ag ( 5 nM ) , naive CD 4 ( + ) T cells express CD 40 ligand and OX 40 , whereas at higher doses ( 50 nM ) , they express Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tumor specific CTL kill murine renal cancer cells using both perforin and Fas ligand mediated lysis in vitro , but cause tumor regression in vivo in the absence of perforin . ^^^ These CTL mediated tumor specific H 2K ( d ) restricted lysis and production of IFN gamma , TNF alpha , and Fas ligand ( FasL ) in response to Renca . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RESULTS : Decoy receptor 3 ( DcR 3 ) , a nonfunctional receptor that binds to Fas ligand ( FasL ) , was constitutively expressed at high level in keratinocytes but decreased rapidly in cells exposed to UVB . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas ligand susceptible `` memory ' ' cells in mice but not in human : potential role of soluble Fas ligand in deletion of auto reactive cells . ^^^ Human soluble Fas ligand ( sFasL ) has an apoptotic activity in contrast to murine sFasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Additionally , they are selective for TNF alpha as they do not inhibit apoptosis induced by soluble Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
HIV Tat binds Egr proteins and enhances Egr dependent transactivation of the Fas ligand promoter . ^^^ HIV Tat can enhance activation induced up regulation of Fas ligand ( FasL ) , which may contribute to T cell apoptosis in human immune deficiency virus ( HIV ) infected individuals . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
No significant difference in the expression of mRNAs of Fas ligand or CAD ( caspase 3 related DNase ) was detected between the involved and uninvolved epidermis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The present study was conducted to investigate soluble Fas ( sFas ) , soluble Fas ligand ( sFasL ) , and tumor necrosis factor alpha ( TNF alpha ) in patients with acute pancreatitis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The apoptotic response was FAS receptor and neutral sphingomyelinase dependent and independent of FAS ligand expression , and neither chelation of intracellular and extracellular Ca ( 2+ ) nor down regulation of PKC expression altered the apoptotic effects of bile acids . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Quantitative gene expression of TGF beta 1 , IL 10 , TNF alpha and Fas Ligand in renal cortex and medulla . ^^^ METHODS : In order to establish reference values for intrarenal gene expression of TGF beta 1 , IL 10 , TNF alpha and Fas Ligand in renal cortex and medulla , we analysed 28 histologically normal kidney samples available after tumour nephrectomy by quantitative real time PCR . ^^^ TGF beta 1 was found with the highest gene expression about five PCR cycles ( delta C ( t ) ) after GAPDH with markedly lower results for TNF alpha ( delta C ( t ) approximately 9 ) , IL 10 ( approximately 12 ) and Fas Ligand ( approximately 14 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Differentiation of promyelocytic leukaemia : alterations in Fas ( CD95 / Apo 1 ) and Fas ligand ( CD 178 ) expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The theory that Fas ligand ( FasL ) expressing tumours are immune privileged and can directly counterattack Fas expressing effector T lymphocytes has recently been questioned and several alternative mechanisms have been proposed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand and the fate of antitumour cytotoxic T lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Transfection of tubule cells with Fas ligand causes leukocyte apoptosis . ^^^ BACKGROUND : Since the Fas / Fas Ligand ( FasL ) interaction is recognized as a major pathway of apoptosis in immune cells , we hypothesized that selective expression of FasL by tubular cells ( TC ) may promote the resolution of interstitial inflammation by inducing apoptosis of infiltrating immune cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Moreover , although inhibition of c myc has significant effects on anti CD 3 induced Fas ligand ( FasL ) expression , we have found that the anti CD 3 induced RANKL expression is independent of c myc . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Induction of apoptosis by Fas ligand ( FasL ) of Fas containing cells is a known mechanism involved in the eradication of inappropriate cells during normal development . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Resistance to Fas ligand induced apoptosis . ^^^ We initially established that both transient and constitutive Notch 3 signaling promoted VSMC survival in response to the proapoptotic Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Close association between Fas ligand ( FasL ; CD95L ) positive tumor associated macrophages and apoptotic cancer cells along invasive margin of colorectal carcinoma : a proposal on tumor host interactions . ^^^ The present study was designed to clarify the relationship between Fas ligand ( FasL ; CD95L ) expression and apoptotic cancer cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( CD 95 ) is a death receptor involved in apoptosis induction on engagement by Fas ligand ( CD95L ) . ^^^ Fas ( CD 95 ) is a death receptor involved in apoptosis induction on engagement by Fas ligand ( CD95L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
During ganciclovir treatment of an adolescent ependymoma patient two weeks after intracranial implantation of HSVtk retroviral vector producer cells , increasing numbers of peripheral T and B cells were found as well as enhanced T cell activation and elevated serum levels of interleukin 12 and soluble Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , the secretion of typical markers of the apoptosis process , such as Fas , soluble Fas ligand , and bcl 2 , was investigated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Adenoviral vectors have been constructed that express the transgenes luciferase ( Adeno HSP Luc ) or Fas ligand ( Adeno HSP FasL ) under the control of the heat shock protein 70B ( hsp70B ) promoter . ^^^ Animals receiving Adeno HSP FasL in the absence of ultrasound treatment did not display liver toxicity , whereas animals receiving ultrasound treatment to induce the expression of Fas ligand from the hsp70B promoter had significant increases in serum levels of liver enzymes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Trypanosoma cruzi infection selectively renders parasite specific IgG+ B lymphocytes susceptible to Fas / Fas ligand mediated fratricide . ^^^ We show in this study that Trypanosoma cruzi infection induces up regulation of both Fas and Fas ligand ( FasL ) molecules on B cells and renders them susceptible to B cell B cell killing ( referred to as fratricide throughout this paper ) mediated via Fas / FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Role of p 38 mitogen activated protein kinase phosphorylation and Fas Fas ligand interaction in morphine induced macrophage apoptosis . ^^^ Morphine also enhanced the expression of both Fas and Fas ligand ( FasL ) , whereas anti FasL Ab prevented morphine induced macrophage apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These macrophages express murine Fas ligand in a doxycycline inducible manner with autocrine suicide inhibited by concomitant expression of p 35 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Programmed cell death can be induced by a number of physiological and pathological factors including Fas ( CD 95 ) Fas ligand ( FasL / CD95L ) interaction , tumour necrosis factor ( TNF ) , ceramide , and reactive oxygen species ( ROS ) . ^^^ Activation induced cell death : the controversial role of Fas and Fas ligand in immune privilege and tumour counterattack . ^^^ In this review the involvement of Fas and Fas ligand in cell death , with particular reference to the T cell , and the mechanism ( s ) by which they induce cell death is described . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In various representatives of enterobateria different proteins serve as Fas ligand , viz . protein IpaB in Shigella flexneri , SipB activating converting enzyme IL 1 beta , identical to capsase 1 , in Salmonella spp . , YopP in Yersinia spp . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In a rodent system , melanoma cells expressing Fas ligand ( FasL ) could kill Fas positive lymphocytes , suggesting that FasL expression was an essential factor for melanoma cell survival in vivo . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Studies concerning the expression of the receptor CD 95 ( Fas ) by tumor cells and the role of this protein in apoptosis induced by the effector host cells that bear Fas ligand are mainly focused on the membrane bound form of Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recent evidence suggests that immune mediated gastric epithelial cell apoptosis through Fas Fas ligand interactions participates in Helicobacter pylori disease pathogenesis . ^^^ To define the role of Fas signaling in vivo , H . pylori strain SS 1 infection in C57BL / 6 mice was compared to that in mice deficient in the Fas ligand ( gld ) . gld mice had a degree of gastritis similar to that of C57BL / 6 mice after 6 weeks ( gastritis score , 5 . 2 + / 0 . 6 [ mean + / standard error ] versus 3 . 5 + / 0 . 8 ) and 12 weeks ( 4 . 0 + / 0 . 7 versus 3 . 4 + / 0 . 5 ) of infection . ^^^ These data demonstrate that mice with mutations in the Fas ligand develop more severe premalignant mucosal changes in response to infection with H . pylori in association with both an impaired gastric epithelial cell apoptotic response and IFN gamma production . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Male germ cell death in mouse testes : possible involvement of Fas and Fas ligand . ^^^ The issue of whether the Fas and Fas ligand ( FasL ) system is involved in the induction of germ cell apoptosis in normal and damaged testes is then addressed , including consideration of both the ischemia reperfusion model of testicular torsion and the estrogen treated testis model of environmental endocrine disruption . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Compared with WT kidneys , rejecting IRF 1KO kidneys showed less induction of donor MHC yet had similar mRNA levels of perforin , granzyme B , and Fas ligand and evoked host alloantibody responses . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Differential expressions of Fas and Fas ligand in human placenta . ^^^ To investigate the expressions of Fas and Fas ligand ( FasL ) in human placenta , we studied the expressions of Fas and FasL in placenta with RT PCR , immunoblotting and immunostaining . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand is barely detectable , which suggests that cytotoxic granule exocytosis may be the dominant pathway leading to keratinocyte cell damage . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interestingly , gld mice with a non functional Fas ligand ( Tnfsf6 / FasL / CD95L ) were as sensitive to radiation as wild type animals , and levels of FasL mRNA were not affected by radiation treatment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ets 1 positively regulates Fas ligand transcription via cooperative interactions with Sp 1 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Aberrant expression of Fas ligand in mice deficient for the MHC class 2 transactivator . ^^^ In this study , we show that these mice also have aberrant Fas ligand expression on both CD 4 T cells and B cells . ^^^ We found that Fas ligand expression was greatly increased on CIITA deficient CD 4 T cells during the Th 1 differentiation process . ^^^ However , both CIITA deficient and control Th 1 effector cells up regulated Fas ligand to similar levels if cells were reactivated . ^^^ The introduction of CIITA into primary CD 4 T cells via retroviral infection resulted in a reduction in the level of Fas ligand and delay in apoptosis after activation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Because NK1 . 1 ( + ) T cells express the Fas ligand and produce high levels of the immunosuppressive cytokine , IL 4 , they may play a role in both activated T cell apoptosis and a Th 1 to Th 2 immune shift , thus promoting tolerance induction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand are required for psoralen and UVA induced apoptosis in mouse epidermal cells . ^^^ In this study , we used immortalized JB 6 mouse epidermal cells , p 53 ( / ) , and Fas ligand deficient ( gld ) mice to investigate the molecular mechanism by which PUVA induces cell death . ^^^ These results indicate that PUVA treatment induces apoptosis in mouse epidermal cells in vitro and in vivo and that p 53 and Fas / Fas ligand interactions are required for this process , at least in vivo . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We detected Fas Fas ligand binding and assembly of death inducing signaling complexes ( DISCs ) [ Fas , Fas associated protein with death domain , and procaspase 8 or procaspase 10 ; receptor interacting protein ( RIP ) RIP associated interleukin 1beta converting enzyme and CED 3 homolog 1 / Ced 3 homologous protein with a death domain procaspase 2 ] by immunoprecipitation and immunoblotting within mouse parietal cortex after controlled cortical impact . ^^^ To address whether Fas functions as a death receptor in brain cells , cultured embryonic day 17 cortical neurons were transfected with an adenoviral vector containing the gene encoding Fas ligand . ^^^ After 48 hr in culture , Fas ligand expression and Fas procaspase 8 DISC assembly increased , and by 72 hr , cell death was pronounced . ^^^ These data suggest that Fas associated DISCs assemble in neurons overexpressing Fas ligand as well as within mouse and human contused brain after TBI . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas Ligand ( FasL ) is a member of the TNF superfamily that induces apoptosis in susceptible cells upon cross linking of its own receptor , Fas ( Apo 1 / CD95 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Diminished tumoricidal activity correlated with reduced expression of mRNAs coding for granzyme B , perforin , Fas ligand and tumor necrosis factor ( TNF ) related apoptosis inducing ligand ( TRAIL ) , as well as with diminished Nalpha CBZ L lysine thiobenzylester ( BLT ) esterase activity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURE ( S ) : Percentage of positive cumulus cells when assessed for nuclear DNA damage using the terminal deoxyuridine nucleotide end labeling assay or stained with antibodies [ Fas , Fas ligand , the antiapoptotic protein Bcl xl , and the RNA binding protein ( TIAR ) ] . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand is barely detectable , suggesting that cytotoxic granule exocytosis may be the dominant pathway leading to keratinocyte cell damage . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of proteins and cytokines participating in the apoptotic process ( caspase 1 , caspase 3 , Fas [ CD 95 ] , Fas ligand [ Fas L ] , perforin , granzyme A , Bax , WAF 1 , Bcl 2 , interleukin 2 [ IL 2 ] , IL 18 , and granulocyte macrophage colony stimulating factor ) in tissue in the acute and convalescent stages of dysentery was quantified at the single cell level by in situ immunostaining . ^^^ Apoptosis in acute shigellosis is associated with increased production of Fas / Fas ligand , perforin , caspase 1 , and caspase 3 but reduced production of Bcl 2 and interleukin 2 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Akt / protein kinase B phosphorylates forkhead transcription factors and prevents their nuclear localization , leading to repression of genes involved in apoptosis , such as Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas ligand and atherosclerosis in hypertensive patients . ^^^ BACKGROUND : The Fas Fas ligand ( FasL ) system is involved in apoptosis in many types of cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas ligand and atherosclerosis in hypertensive patients . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
No modifications in the steady state levels of Bcl 2 , Bax , Fas and Fas ligand were observed following infection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This study was conducted to clarify whether soluble forms of Fas ( sFas ) and Fas ligand ( sFasL ) are concerned with inflammation in IBD . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : Although chemotherapeutic agents are known to sensitize some tumour types to killing through cell surface death receptors for Fas ligand and tumour necrosis factor related apoptosis inducing ligand ( TRAIL ) , chemosensitization of breast carcinoma cells has not yet been explored . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
MATERIALS AND RESULTS : In 41 CIN and SCC tissues , the expression of survivin , Fas ligand , Fas and bcl 2 was studied by immunohistochemistry . ^^^ Alteration of Fas ligand , Fas and bcl 2 expression was detected in 12 . 5 % 25 % of HSIL and in 7 . 7 % 30 . 8 % of SCC but no abnormal expression was found in LSIL . ^^^ CONCLUSION : Survivin expression seems to be more closely related to the progression of CIN and SCC compared to Fas ligand , Fas and bcl 2 . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Antitumor effects are produced by forced expression of membrane bound but not soluble Fas ligand in murine lung carcinoma cells . ^^^ Interaction of Fas and Fas ligand ( FasL ) in immunocompetent cells plays a crucial role ( s ) in their effector functions and in the regulation of host immune responses . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although nitric oxide and Fas ligand have been shown to be inducers of chondrocyte apoptosis in vitro and in vivo , the contribution of other triggers such as hypoxia , matrix acidosis , abnormal shear stress and catabolic cytokines like interleukin 1beta and tumour necrosis factor alpha has not been examined . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The role of Fas ligand in beta cell destruction in autoimmune diabetes of NOD mice . ^^^ Fas ligand ( FasL ) , a type 2 membrane protein belonging to the TNF family , plays an important role in the induction of cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression levels of the Fas ligand ( FasL ) in Sertoli cells and of both Fas and caspase 3 in germ cells of ETR detected immunohistochemically were higher than those of the control testes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The 15d PGJ ( 2 ) induced accumulation of p 53 resulted in the activation of a death inducing caspase cascade mediated by Fas and the Fas ligand . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the clamped kidney , the accumulated intermediate T cells had less cytotoxic activity against tumor cells ; however , the expression of the Fas ligand ( FasL ) increased , indicating a cell mediated tissue injury via the Fas / FasL system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Hepatocyte nuclear factor ( HNF ) 4alpha induces expression of endothelial Fas ligand ( FasL ) to prevent cancer cell transmigration : a novel defense mechanism of endothelium against cancer metastasis . ^^^ Endothelial Fas ligand ( FasL ) contributes to the `` immune privilege ' ' of tissues such as testis and eye , in which apoptosis is induced in infiltrating Fas positive activated T cells and results in the inhibition of leukocyte extravasation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Circulating soluble Fas ligand correlates with disease activity in Graves ' hyperthyroidism . ^^^ Meanwhile , the Fas / Fas ligand ( FasL ) apoptosis pathway has received much attention in physiological homeostasis and immune regulation in various thyroid diseases , including Graves ' hyperthyroidism ( GD ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In a mouse model of pancreatic acinar to ductal metaplasia , MMP 7 progressively accumulates during the metaplastic transition , resulting in a concomitant increase in solubilization of Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A more controversial view is that cell death pathways , for example those involving FasR ( CD 95 ) may be activated in cycling HSC , resulting in their selective destruction upon transplantation and localization to sites rich in Fas ligand such as the liver . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The level of soluble Fas ligand in the plasma was increased , and Fas receptor in the liver was overexpressed in the CHF animals . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Gammadelta T cells promote a Th 1 response during coxsackievirus B 3 infection in vivo : role of Fas and Fas ligand . ^^^ Fas / Fas ligand ( FasL ) interactions regulate disease outcome in coxsackievirus B 3 ( CVB 3 ) induced myocarditis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
ASC was also increased by incubation with either anti Fas antibody or recombinant soluble Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , induction of Fas ligand ( FasL ) mRNA and functional FasL protein was delayed and decreased in IRS 1 expressing cells , but not in IRS 2 expressing cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas ligand in the bronchoalveolar lavage fluid ( BALF ) from patients with idiopathic pulmonary fibrosis ( IPF ) also induced apoptosis of cultured bronchiolar epithelial cells that was significantly attenuated by anti TGF beta Ab . ^^^ Otherwise , BALF from patients with hypersensitivity pneumonitis ( HP ) could not induce apoptosis on bronchiolar epithelial cells , despite its comparable amounts of soluble Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Concanavalin A ( Con A ) induced hepatitis is an experimental model of immune mediated liver injury in which natural killer T ( NKT ) cells play a critical role through the production of interleukin ( IL ) 4 and the expression of Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cytotoxic lymphocytes kill tumor or virus infected target cells utilizing two mechanisms ( 1 ) release of lytic granules ( containing perforin and granzymes ) , and ( 2 ) Fas ligand ( FasL ) / Fas or TNF initiated apoptosis . ^^^ A direct correlation has been found between the percentage of dead target cells in FC Assay and the results of 111In release cytotoxicity assay when effector T cells from either Pfp / ( perforin knockout ) or gld ( non functional Fas Ligand ) mice were used . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Upregulation of mucosal soluble fas ligand and interferon gamma may be involved in ulcerogenesis in patients with Helicobacter pylori positive gastric ulcer . ^^^ METHODS : The contents of soluble Fas ligand ( sFasL ) and interferon gamma ( IFN gamma ) in organ cultures and the degree of apoptosis and the expression of apoptosis related proteins in the gastric epithelium were examined using the mucosal tissues obtained from the antrum and the ulcer site in patients with H . pylori positive gastric ulcer ( GU ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL ) was determined by reverse transcriptase polymerase chain reaction analysis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Graft survival , histological appearance and intragraft gene expression ( IL 2 , IFN gamma , IL 12 p 40 , IL 4 , IL 10 , perforin , Fas ligand ( Fas L ) , iNOS and TNF alpha ) were compared for fully allogeneic , minor histocompatibility ( mHC ) antigen mismatched and syngeneic skin and heart grafts . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Finally , we noted the lack of effect of Nurr 1 protein on the Fas Ligand promoter driven transcription . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TUNEL staining detected apoptotic T cells at low frequency corresponding to an increased expression of the anti apoptotic molecules Bcl 2 and Bcl 10 ( L ) and a reduced expression of the pro apoptotic molecules Bad , Bax , and Fas ligand in CD 4 and CD 8 T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recent work in murine models show that these cells mediate cytotoxicity by using a perforin granzyme and not through Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To delineate luteotropic roles of PRL in terms of luteal vascularization and immune privilege , luteal expression of Thy 1 differentiation protein , Fas , and Fas ligand ( FasL ) in early pregnancy was studied in hamsters on Day 4 of pregnancy ( P 4 group ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The apoptosis of lymphocytes , which occurs in autoimmune diseases , is usually induced by the Fas / Fas ligand system . ^^^ As the assay of nucleosomes produced by apoptotic cells can be used to quantitate apoptosis , we evaluated nucleosome and soluble Fas ligand ( sFasL ) levels of cultured mononuclear cells to clarify the apoptosis of mononuclear cells in patients with autoimmune thyroid diseases by enzyme linked immunosorbent assay . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Sensitivity to apoptosis signal , clearance rate , and ultrastructure of fas ligand induced apoptosis in in vivo adult cardiac cells . ^^^ METHODS AND RESULTS : To minimize the systemic influence , soluble Fas ligand was injected directly into in vivo rat hearts and livers ( as the control ) at concentrations of 0 , 0 . 5 , 2 , and 5 microg / mL ( groups C , F0 . 5 , F 2 , and F 5 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Whereas epithelial apoptosis seems to be mainly mediated by Fas ligand , the mediators of endothelial damage remain to be identified . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of CD 40 and Fas ligand in Bowen ' s disease , squamous cell carcinoma and basal cell carcinoma . ^^^ Impaired regulation of apoptosis is known to be associated with the development of various cancers , and Fas / Fas ligand ( FasL ) is known to play an important role in apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 4 ( + ) T cell death was mediated by Fas ligand , because CD 4 ( + ) T cells from Fas ligand deficient gld mice did not undergo activation induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand and tumor necrosis factor bind to their receptors and induce apoptosis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , Graves ' thyrocytes are protected from apoptotic death possibly by the anti apoptotic action of thyrotrophin receptor antibodies or soluble Fas and / or the overexpression of Fas ligand which all create an anti apoptotic potential for the thyroid cells and favor apoptosis of the infiltrating lymphocytes . ^^^ Furthermore , malignant thyroid cells may escape immune attack by over expressing Fas ligand and inducing apoptosis in the invading immune cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( Apo 1 / CD95 ) is a cell surface receptor involved in cell death signaling through binding of Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the murine primary SS model , tissue infiltrating CD 4 ( + ) T cells purified from the salivary glands bear a large proportion of Fas ligand , and the salivary gland duct cells constitutively possess Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
High concentrations of soluble Fas ligand in bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis . ^^^ We postulated that apoptosis through the Fas / Fas ligand ( L ) system may be associated with regulation of immune reactions characterized by the formation of noncaseous necrotizing granulomas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Abnormal expression and function of Fas ligand of lacrimal glands and peripheral blood in Sjgren ' s syndrome patients with enlarged exocrine glands . ^^^ The objective of our study was to investigate the possibility of Fas ligand protein abnormalities in certain types of Sjgren ' s syndrome patients with enlarged exocrine glands . ^^^ Fas ligand expression by lymphocytes infiltrating the lacrimal glands and by peripheral blood monocytes in Sjgren ' s syndrome patients with enlarged exocrine glands was assessed immunohistologically and by immunoblotting . ^^^ Minimal Fas ligand expression was detected in the lymphocytes of the lacrimal glands and a decreased level of Fas ligand was found in peripheral blood monocytes as assessed by immunoblotting . ^^^ Functional assay confirmed the decreased cytotoxicity of lymphocytes in Sjgren ' s syndrome patients with enlarged exocrine glands , and that it is not affected by anti Fas ligand antibody . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand : expression and soluble circulating levels in cutaneous malignant melanoma . ^^^ BACKGROUND : The Fas / Fas ligand ( FasL ) system plays a key part in maintaining tissue homeostasis via the induction of apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand upregulation is an early event in colonic carcinogenesis . ^^^ BACKGROUND / AIMS : Fas ligand ( FasL ) is a mediator of apoptosis via the Fas receptor ( Fas / CD95 / APO 1 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Pleural effusion and serum soluble fas ligand levels are elevated in different clinical conditions . ^^^ Fas ligand ( FasL ) plays an important role in the regulation of apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Investigation of Bcl 2 , Bax , Fas , Fas ligand ( FasL ) and activated caspase 3 , key regulators of apoptosis that can be modulated by cytokines , revealed complex alterations of mRNA and protein levels in MCP 1 ( / ) and CCR 2 ( / ) mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These shed membrane fragments were further analyzed for the presence of Fas ligand ( FasL ) and modulation of CD 3 zeta expression on cultured T lymphocytes ( Jurkat cells ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Third , an immunological barrier , consisting of Fas ligand on Sertoli cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Wild type FADD rescued both Fas ligand and TNF dependent signaling , whereas the FADD death effector domain mutants rescued only TNF signaling . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Noting that T cells can mediate graft versus leukemia ( GVL ) responses via both perforin ( usually co expressed in cytotoxic granules with DPPI ) and Fas ligand pathways in a murine model , we hypothesized that LLME might be useful for treatment of delayed DLIs for potential GVL activity with a decreased risk of GVHD induction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The use of Fas Ligand , TRAIL and Bax in gene therapy of prostate cancer . ^^^ This review covers the use , in gene therapy , of apoptotic inducing molecules such as Fas Ligand , and TRAIL which are believed to induce bystander killing activity and Bax which also may function in a similar way . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The prognostic significance of overexpression of the decoy receptor for Fas ligand ( DcR 3 ) in patients with gastric carcinomas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
H ( 2 ) O ( 2 ) induces upregulation of Fas and Fas ligand expression in NGF differentiated PC 12 cells : modulation by cAMP . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
An immortalized human oligodendrocyte hybrid line ( MO3 . 13 ) was challenged with Fas ligand ( FasL ) , and cell death was assessed by flow cytometry and DNA gel electrophoresis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Regulation of Fas ligand expression by estrogen in normal ovary . ^^^ OBJECTIVE : The clinical significance of the Fas / Fas ligand ( FasL ) system in hormone sensitive carcinomas such as breast and ovary has been reported . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble HLA 1 ( sHLA 1 ) molecules induce soluble Fas ligand ( sFasL ) secretion and trigger apoptosis in phytohemagglutin ( PHA ) activated Fas+ T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Fas ligand system and apoptosis induction in testicular carcinoma . ^^^ BACKGROUND : Tumor infiltrating , Fas ligand ( FasL ) expressing lymphocytes are able to eliminate Fas bearing tumor cells by apoptosis induction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Inducing apoptosis of activated lymphocytes via Fas ligand ( FasL , CD 95 ) may be a useful strategy for the treatment of autoimmune diseases mediated by pathogenic T cells . ^^^ B cells engineered to express Fas ligand suppress pre sensitized antigen specific T cell responses in vivo . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Semiquantitative reverse transcription PCR showed that expression of Fas ( CD 95 ) mRNA was up regulated as early as 6 h after addition of excretory secretory product , while Fas ligand expression and p 53 expression were not up regulated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ligation of Fas by Fas ligand or an anti Fas cross linking antibody triggers receptor trimerization followed by recruitment of FADD to the cytoplasmic domain of the receptor and the activation of the caspase cascade . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the hypothesis that the proinflammatory cytokines and lipopolysaccharide ( LPS ) in gram negative sepsis can directly cause renal tubular cell apoptosis via Fas and caspase mediated pathways , we examined apoptosis and Fas , Fas ligand , FADD expression , as well as PARP cleavage in cultured human proximal tubular cells under the cytokine and LPS stimulated conditions . ^^^ Fas expression was examined by RT PCR and Fas ligand , Fas associated protein with death domain ( FADD ) and poly ADP ribose polymerase ( PARP ) cleavage were examined by Western blot analysis . ^^^ Fas ligand protein expression did not increase in the low dose TNF alpha treated group , but it increased significantly in the high dose TNF alpha treated group ( p < 0 . 01 ) , IL 1beta and LPS treated groups ( p < 0 . 01 , p = 0 . 01 , p < 0 . 01 , p = 0 . 02 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The CsA group showed a significant increase in Fas ligand mRNA ( 0 . 20 vs . 0 . 02 amol / microgram total RNA , p < 0 . 05 ) and Fas protein expression ( 146 % vs . 95 % , p < 0 . 05 ) , compared with the VH group . ^^^ Immunohistochemical detection of Fas , Fas ligand , ICE and CPP 32 revealed strong immunoreactivity in renal tubular cells in areas of structural injury . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand expression is elevated in prostatic intraepithelial neoplasia and prostatic adenocarcinoma . ^^^ On binding to Fas ligand , a Type 2 transmembrane protein , the Fas / Fas ligand complex , induces apoptosis in target cells . ^^^ Dysregulation of Fas and Fas ligand expression has been found in some malignant neoplasms . ^^^ METHODS : Using immunohistochemical analysis , the authors studied the expression of Fas and Fas ligand in prostatic adenocarcinoma , high grade prostatic intraepithelial neoplasia ( PIN ) , and adjacent benign prostate tissue from 95 radical prostatectomy specimens . ^^^ The percentage of cells that stained positively with Fas ligand in benign prostate tissue ( mean , 13 % ) was statistically significantly lower compared with that in PIN ( mean , 47 % ; P = 0 . 0001 ) and in prostatic adenocarcinoma ( mean , 53 % ; P = 0 . 0001 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas Fas ligand system as a possible mediator of spermatogenic cell apoptosis in human maturation arrested testes . ^^^ To elucidate the mechanism of maturation arrest , known as one of the male infertility , we addressed whether germ cell apoptosis occurs during maturation arrest , and if so , whether Fas and Fas ligand expressions are involved in the apoptosis . ^^^ On the other hand , positive immunostaining for Fas ligand was restricted to Sertoli cells in the maturation arrested testes as well as in the normal testes , although the intensity of staining for Fas ligand in normal testicular Sertoli cells was much weaker than that of maturation arrested ones . ^^^ Thus , these findings demonstrate that `` maturation arrest ' ' is characterized by frequent apoptosis of spermatocytes , and that Fas and Fas ligand staining are associated with a high frequency of apoptosis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
When HPK 1 was overexpressed in murine CD 4 ( + ) T cells , a substantial increase was observed in spontaneous and TCR / CD3 mediated apoptosis as well as in Fas ligand ( FasL ) expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Fas ligand pathway is involved in the resolution of type 2 pneumocyte hyperplasia after acute lung injury : evidence from a rat model . ^^^ Lung specimens from all animals were examined for the presence of apoptosis in type 2 pneumocytes by an in situ apoptosis assay and for proliferative nuclear antigen , cytokeratin 18 , Fas , and Fas ligand with an immunohistochemical stain . ^^^ Fas and Fas ligand expression in both lung tissue and bronchoalveolar lavage fluid was examined by Western blot analysis . ^^^ The major cell types expressing Fas ligand are macrophages and neutrophils . ^^^ Western blot analysis showed that Fas ligand , both membrane bound form and soluble form , was present from day 1 to day 21 after acute lung injury , with highest level occurring during the first week of acute lung injury . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand exists on intervertebral disc cells : a potential molecular mechanism for immune privilege of the disc . ^^^ Reverse transcription polymerase chain reaction ( RT PCR ) analysis was also performed on rat disc tissue to demonstrate the existence of Fas ligand . ^^^ OBJECTIVE : To clarify the existence of Fas ligand on intact intervertebral disc cells . ^^^ The immune privileged characteristic in other tissues such as the retina and testis has been attributed to the local expression of Fas ligand , which acts by inducing apoptosis of invading Fas positive T cells . ^^^ The existence of Fas ligand in normal disc cells has not yet been addressed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Both the degree of liver injury and the degree of Fas and Fas ligand expression in the OM pretreated group were reduced remarkably ( P < 0 . 01 and 0 . 05 respectively ) when compared with the saline control group . ^^^ CONCLUSIONS : Oxymatrine protects mice from fulminant hepatitis induced by GalN / LPS and may block hepatocyte apoptosis and subsequent necrosis through downregulating the production of serum tumor necrosis factor alpha and the expression of Fas and Fas ligand in liver tissue . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Intrathecal Fas ligand infusion strengthens immunoprivilege of central nervous system and suppresses experimental autoimmune encephalomyelitis . ^^^ Fas ligand ( FasL ) is an essential molecule strongly expressed in some immunoprivileged sites , but is expressed at very low levels in normal CNS . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expanded population of alpha / beta DNTCs from ALPS patients has a remarkable uniform phenotype that is for the most part similar to alpha / beta DNTCs from mice with defective Fas ( lpr ) or Fas ligand ( gld ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Membrane bound Fas ligand ( FasL , Apo 1L , CD95L ) induces rapid apoptosis of Fas ( CD 95 ) sensitive cells on interaction with Fas , and is an important effector molecule of cytolytic T lymphocytes ( CTLs ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , tumor cells frequently exhibit de novo expression of Fas ligand ( FasL ) which plays a significant role in local tissue destruction , metastatic spread and immune escape of the tumor cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis was triggered with the oxidant tert butylhydroperoxide ( tBH ) , recombinant soluble Fas ligand ( sFasL ) , or agonistic anti Fas antibody ( CH 11 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
MUC1 tumor cell line was primarily mediated by CD 4 ( + ) T cells , and required Fas ligand , lymphotoxin alpha , CD 40 , CD 40 ligand and CD 28 , but not perforin , gammadelta T cells , IL 4 , IL 10 , IL 12 or tumor necrosis factor receptor 1 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The CXC chemokine interferon gamma inducible protein 10 ( IP 10 ) and monokine induced by interferon gamma ( MIG ) cause tissue necrosis , and interleukin ( IL ) 18 induces the expression of IFN gamma and Fas ligand ( FasL ) by T and natural killer ( NK ) cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the immune privilege induced by the Fas ligand ( FasL ) expressed by cotransplanted testicular Sertoli cells in islet allografts , and the effect of FasL gene transfection on islet cells in pancreatic islet allografts . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Significant role of Fas ligand binding but defective Fas receptor ( CD 95 ) in lymph node hyperplasia composed of abnormal double negative T cells . ^^^ Taken together with the fact that DN T cells massively express Fas ligand ( FasL ) , this study implied that FasL overexpressed on DN cells may be involved in the accumulation of DN T cells in LN , LN atrophy and wasting syndrome , and that lprcg Fas , which can bind to Fas ligand but not transduce apoptosis signal into cells , may modulate these pathological conditions by interfering with the binding of FasL to Fas . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Inflammatory signals increase Fas ligand expression by inner ear cells . ^^^ Recently , expression of Fas ligand ( FasL ) in some non lymphoid tissue , as in the anterior chamber of the eye , has been hypothesized to play a role in protection of sensitive organs from activated T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Regulation of fas ligand expression by IL 8 in human endometrium . ^^^ We hypothesized that increased levels of IL 8 in the endometriotic environment could up regulate Fas ligand ( FasL ) expression in endometrial cells and may be relevant for the development of a relative local immunotolerance in endometriosis by inducing apoptosis of cytotoxic T lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Localization of Fas ligand in cytoplasmic granules of CD8+ cytotoxic T lymphocytes and natural killer cells : participation of Fas ligand in granule exocytosis model of cytotoxicity . ^^^ Fas ligand ( FasL ) has been implicated in cytotoxic T lymphocyte ( CTL ) and natural killer ( NK ) cell mediated cytotoxicity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas ( Apo 1 / CD95 ) / Fas ligand ( L ) system is involved in cell death signaling , and has been suggested to be important for the regulation of germ cell apoptosis in the testis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It is possible that Fas , Fas ligand , p 53 , p 21 , and other apoptosis regulating proteins may play important roles in the pathophysiology of lung injury and fibrosis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the thymus , several genes encoding caspases , and members of the TNF family , including Fas ligand , were induced . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis related proteins ( Fas , Fas ligand , bcl 2 and p 53 ) in different types of human breast tumors . ^^^ The aim of this study was to evaluate the possible role of apoptosis related proteins ( ARP : Fas and Fas ligand , bcl 2 , p 53 ) in the progress of tumorigenesis in breast cancer . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Foetal calf serum , Fas ligand , and tumour necrosis factor alpha served as modulatory control agents ; survival promoting and apoptosis inducing activities of the respective agents were confirmed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas ligand ( sFasL ) in the sera of these individuals was quantitated by ELISA . ^^^ This suggested utilization of sFasL produced in vivo and activation of the Fas / Fas ligand ( FasL ) pathway in Fas ( + ) T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Gel mobility shift analysis using nuclear extracts from the CA 1 region prepared immediately after reperfusion revealed increases in DNA binding activity for the FKHR responsive element on the Fas ligand promoter . ^^^ Two days after reperfusion , expression of Fas ligand increased in the CA 1 region and the orthovanadate injection inhibited this increased expression . ^^^ These results suggest that the inactivation of Akt results in the activation of FKHR and , in turn , relates to the expression of Fas ligand in the CA 1 region after transient forebrain ischemia . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( CD95 / APO 1 ) and Fas ligand expression in normal pancreas and pancreatic tumors . ^^^ BACKGROUND : Fas ( CD95 / APO 1 ) and Fas ligand ( FasL ) play key roles in immunologic homeostasis and immune privilege and may regulate normal cell turnover . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Western blot analysis was performed to examine the protein expressions of Fas and Fas ligand In addition , the amounts of apoptotic cells were determined by 4 ' , 6 diamidino 2 ' phenylindol dihydrochloride ( DAPI ) and propidium iodide ( PI ) staining . ^^^ The protein expression of Fas ligand , a natural ligand for Fas antigen , in RSFs . was expressed in untreated RSFs . ^^^ In addition , Fas ligand was expressed in the RSFs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The aim of this study was to investigate role of HBx in expression of interleukin 18 ( IL 18 ) , a newly identified cytokine that up regulates Fas ligand ( FasL ) expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Growth hormone administration reduces circulating proinflammatory cytokines and soluble Fas / soluble Fas ligand system in patients with chronic heart failure secondary to idiopathic dilated cardiomyopathy . ^^^ METHODS : Serum levels of tumor necrosis factor alpha ( TNF alpha ) , its soluble receptors ( sTNF RI , sTNF RII ) , interleukin 6 ( IL 6 ) , soluble IL 6 receptor ( sIL 6R ) , soluble Fas ( sFas ) and soluble Fas Ligand ( sFasL ) were determined ( enzyme linked immunosorbent assay method ) in 10 patients with IDC ( New York Heart Association class 3 , ejection fraction 24 % + / 2 % ) before and after a 3 month subcutaneous administration of 4 IU GH every other day ( randomized crossover design ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To elucidate the cellular mechanism , we used a Fas ligand ( Fas L ) specific ribozyme ( Fas L ( ribozyme ) ) to suppress the expression of Fas L but not Fas or TNF alpha in B16F10 melanoma cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : We investigated the apoptosis inducing activities of h HFE7A on human Fas ligand transfected cells and cultured human activated lymphocytes ( human peripheral blood mononuclear cells and isolated human RA synovial lymphocytes ) , synoviocytes , and chondrocytes . ^^^ RESULTS : Administration of h HFE7A Mab alone did not induce apoptosis in cultured human Fas ligand transfected cells and activated lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In fact , increased activation induced apoptosis in the remaining peripheral lymphocytes and elevated levels of soluble Fas ligand were detected at admission to the hospital . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
First , are summarized the main induction pathways of radiation induced apoptosis by which extracellular ( tumor necrosis factor ( TNF ) , Fas ligand , TNF related apoptosis inducing ligand ( TRAIL ) ) and intracellular ( mitochondria and caspases ) signals are integrated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Virus infected ORNs revealed upregulated expression of the Fas ligand molecules , activating the c Jun N terminal kinase signal transduction pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Death of CTL is shown to involve interaction of Fas with Fas ligand , pointing to fratricide between activated CTL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The interior of the eye is decorated with Fas ligand ( CD95L ) , which induces apoptosis of infiltrating inflammatory cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Both Fas and Fas ligand ( FasL ) are expressed in activated mature T cells , and prolonged cell activation induces susceptibility to Fas mediated apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Membrane Fas ligand activates innate immunity and terminates ocular immune privilege . ^^^ It has been proposed that the constitutive expression of Fas ligand ( FasL ) in the eye maintains immune privilege , in part through inducing apoptosis of infiltrating Fas ( + ) T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , caspase 3 , Fas ligand , Fas / CD95 , and PAI showed an inverse correlation to lymph node involvement . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Transmission electron microscopy of pEC cocultured with hNK cells showed both apoptotic and necrotic cell death , whereas soluble factors such as Fas ligand or TNFalpha did not induce apoptosis in pEC . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas / Fas ligand system induces apoptosis , while soluble Fas ( sFas ) blocks the system and soluble Fas ligand ( sFasL ) functions to induce apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Mechanisms of nonspecific cytotoxic cell regulation of apoptosis : cytokine like activity of Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Plasma levels of beta ( 2 ) microglobulin and soluble Fas , Fas ligand , CD 8 , CD 4 , and TNF receptor were increased , and soluble CD 8 was higher in boys than in girls . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Previous studies indicate that AgICD of cytotoxic T cells may be induced by either of the two key cytotoxic processes , granule exocytosis , including perforin and granzymes , or the Fas ligand ( FasL ) / Fas pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We sought to examine the regulation of the TNF related apoptosis inducing ligand ( TRAIL ) and Fas ligand ( FasL ) induced apoptosis pathways in primary thyroid cells from 17 patients with nodular goiter , using 10 normal thyroids as controls . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Localization of the Fas Fas ligand system in human fetal membranes . ^^^ OBJECTIVE : To determine if fetal membranes might be one of the sources of Fas and Fas ligand in amniotic fluid . ^^^ Expression of Fas and Fas ligand was read by light microscopy . ^^^ RESULTS : Both Fas and Fas ligand were localized in amnion , chorion and decidual layers . ^^^ In amnion , Fas and Fas ligand were expressed predominantly in epithelial cells and fibroblasts , while there was no immunostaining in the subepithelial compact connective tissue . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Antibody binding to fas ligand attenuates inflammatory cell infiltration and cytokine secretion , leading to reduction of myocardial infarct areas and reperfusion injury . ^^^ Fas ligand ( FasL ) induces apoptotic cell death when bound to Fas antigen . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand and TNF related apoptosis inducing ligand ( TRAIL ) induce apoptosis in many different cell types . ^^^ Both TRAIL and Fas ligand have been suggested to regulate the clonal size and persistence of different T cell populations . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Evaluation of soluble Fas ligand as a serological marker for melanoma . ^^^ BACKGROUND : Fas ligand ( Fas L ) , which is expressed by melanoma cells , can be cleaved from cell membranes and become soluble ( soluble Fas L , sFas L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
DUG is constitutively expressed at very low levels in normal cells but is dramatically upregulated in apoptotic cells following serum / glucose starvation or death receptor ligation by Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas antigen ( Fas ) is a cell surface receptor molecule introducing apoptosis inducing signals into Fas bearing cells by stimulation with Fas ligand or agonistic anti Fas monoclonal antibodies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tumour Fas ligand : Fas ratio greater than 1 is an independent marker of relative resistance to tamoxifen therapy in hormone receptor positive breast cancer . ^^^ BACKGROUND : The objective of the present study was to examine the prognostic and predictive significance of the apoptosis related marker Fas ligand ( FasL ) : Fas ratio in breast cancer . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TNF contributes to the immunopathology of perforin / Fas ligand double deficiency . ^^^ Perforin ( pfp ) / Fas ligand ( FasL ) double deficient mice have previously been shown to be infertile , lose weight and die prematurely due to tissue destruction caused by a significant inflammatory infiltrate of monocytes / macrophages and T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Oncogenic ras has been shown to downregulate Fas receptor expression and increase Fas ligand expression and thus contribute to resistance to Fas mediated cell death in several cell types . ^^^ We studied the effects of activated N ras by measuring Fas , Fas ligand , and FLIP expression as well as susceptibility to Fas ligand induced cell death in transfectants of WM 35 , a radial growth phase human melanoma cell line . ^^^ The control and ras transfectants did not express Fas ligand as demonstrated by reverse transcriptase polymerase chain reaction and fluorescence activated cell sorter analysis . ^^^ Cytotoxicity assays further confirmed that these melanoma ras transfectants do not express functional Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Palgin sensitizes the adriamycin induced apoptosis via the enhancement of Fas / Fas ligand expression . ^^^ Interestingly , a synergistic increase in apoptosis by the combination of two drugs was accompanied by the enhancement of Fas and Fas ligand ( FasL ) expression in Chang cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition to a variety of growth factors , chemically modified lipids , reactive oxygen species , proinflammatory cytokines , and Fas ligand produced by activated immune cells may influence cell viability through a diversity of pathways , including the caspase cascade , the Bcl 2 protein family , and the oncogene / antioncogene system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Hence , we extended our studies in a rat aortic allograft model , using adenovirus mediated overexpression of soluble Fas ( sFas ) to block Fas binding to Fas ligand ( Fas L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The AICD inhibition mediated by KIR appears to result from the blockade of Fas ligand induction upon activation of the Jurkat transfectants . ^^^ Taken together these data strongly suggest that KIR inhibits the AICD of T cells by blocking Fas ligand induction upon stimulation , in a process that seems to be accomplished by PKC recruitment to the membrane proximal PKC binding site and subsequent inhibition of PKC activation against the activating stimuli . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We now test the possibility that Fas ( APO 1 / CD95 ) dependent apoptosis of uninfected cells , due to enhanced expression of the Fas ligand ( FasL ) on infected cells , may contribute to the pathology of cryptosporidiosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NK cytotoxicity was mediated by a perforin system , while NKT cytotoxicity was mediated by a Fas ligand system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Actinobacillus actinomycetemcomitans induces apoptosis of T lymphocytes by the Fas and Fas ligand pathway . ^^^ Monocytes were the only cells analyzed to express Fas ligand ( FasL ) constitutively , and this was further up regulated in response to A . actinomycetemcomitans CFCS , while T cells expressed FasL only after this stimulation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , altered TCR ligand induced T cell proliferation in the absence of IETD , DEVD specific caspase activities and Fas ligand expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , we demonstrate that the inhibition of allospecific CTL activity by the NO donor was at least in part related to an inhibition of granzyme B and Fas ligand transcription as revealed respectively by RNase protection and RT PCR analysis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cell detachment triggers p 38 mitogen activated protein kinase dependent overexpression of Fas ligand . ^^^ Indeed , in this study we identified a novel mechanism of anoikis in intestinal epithelial cells that involves detachment induced overexpression of Fas ligand . ^^^ We also demonstrated that this elevation in Fas ligand expression requires a detachment induced increase of p 38 mitogen activated protein kinase activity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Role of Fas / Fas ligand interaction in ischemia induced collateral vessel growth . ^^^ Fas ligand ( FasL ) is a death factor that induces apoptosis in cells bearing its receptor , Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
When lipid rafts were isolated from control and Fas ligand treated cells , we found that a small proportion of Fas was present in the raft fraction in untreated cells and that this was greatly increased upon Fas ligation . ^^^ The other components of the Death Inducing Signalling Complex ( DISC ) , FADD , and procaspase 8 , were also present at higher levels in the raft fraction isolated from Fas ligand treated cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In cell culture models , acute exposure of cells coexpressing Fas and Fas ligand ( FasL ) to matrilysin induces apoptosis , whereas chronic exposure to matrilysin selects for apoptosis resistant cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We investigated whether determination in fine needle aspiration biopsy ( FNAB ) specimens of cells expressing granzymes ( Grs ) and Fas ligand would provide a reliable , easy , and quantitative measure of rejection activity in the transplanted liver . ^^^ Cytospin preparations of FNAB and peripheral blood specimens were immunocytochemically stained for Fas ligand and Gr , and increments in the liver were calculated by subtracting frequencies of positive cells in blood from those in FNAB specimens . ^^^ Only sporadically Fas ligand expressing , but many Gr expressing , cells were detected in FNAB specimens . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Toll like receptor 2 contributes to liver injury by Salmonella infection through Fas ligand expression on NKT cells in mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NKT cells reside in the normal liver but may be involved in liver cell damage possibly through the expression of Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Endothelial cell destruction was assessed in vitro both by 51Cr release and DNA fragmentation using wild type and lpr ( Fas deficient ) endothelium of C3H / HeJ ( H 2 ( k ) ) mice by MHC alloantigen specific T cells of wild type , gld ( Fas ligand deficient ) , and perforin deficient mice on a C57BL / 6 ( H 2 ( b ) ) background . ^^^ RESULTS : Although maximal lysis of 56 . 6+ / 0 . 8 % was seen when using wild type targets and effectors , only a moderate decrease in apoptosis to 37 . 6+ / 4 . 0 % was detected when the Fas / Fas ligand death receptor pathway was eliminated . ^^^ CONCLUSIONS : These data indicate that CTLs destroy vascular endothelium primarily by the perforin / granzyme exocytosis pathway with only a minor contribution to apoptosis by the Fas / Fas ligand death receptor pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand immunolocalization in pancreatic islets of NOD mice during spontaneous and cyclophosphamide accelerated diabetes . ^^^ One involves the Fas FasL ( Fas Fas ligand ) system and the other , the perforin pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The inhibitory effect of IL 6 on Fas ligand expression during activation induced cell death ( AICD ) was augmented in gp 130 ( F759 / F759 ) T cells in a manner dependent on the tyrosine residues of gp 130 required for signal transducer and activator of transcription 3 activation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand expression in pancreatic adenocarcinoma . ^^^ INTRODUCTION : Fas and Fas ligand ( FasL ) mediate apoptosis of tumor cells in immune surveillance , and expression of FasL by tumors may mediate their counterattack on cytotoxic lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cloning and potential utility of porcine Fas ligand : overexpression in porcine endothelial cells protects them from attack by human cytolytic cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Metalloproteinase shedding of Fas ligand regulates beta amyloid neurotoxicity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Elevated soluble Fas ligand levels may suggest a role for apoptosis in women with endometriosis . ^^^ OBJECTIVE : To evaluate soluble Fas ligand concentrations in serum and peritoneal fluid from women with endometriosis and from fertile controls without endometriosis , and to study levels of soluble Fas ligand in conditioned media of cultured endometrial stromal cells . ^^^ MAIN OUTCOME MEASURE ( S ) : Enzyme linked immunosorbent assay was used to measure soluble Fas ligand concentrations in paired samples of serum and peritoneal fluid from women with and without endometriosis . ^^^ RESULT ( S ) : Compared with fertile controls and women with early stage of endometriosis , women with moderate to severe endometriosis had elevated serum ( 87 . 2 + / 6 . 4 , 88 . 2 + / 6 . 9 , and 162 . 3 + / 7 . 8 pg / mL , respectively ) and peritoneal fluid ( 81 . 0 + / 6 . 0 , 80 . 5 + / 6 . 8 , and 166 . 2 + / 10 . 3 pg / mL , respectively ) concentrations of soluble Fas ligand . ^^^ Serum levels of soluble Fas ligand positively correlated with levels in peritoneal fluid . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
When Fas deficient ( C57BL / 6 lpr / lpr ) or Fas ligand defective ( C57BL / 6 gld / gld ) mice were treated with TCDD , they failed to exhibit a decrease in percentage and cellularity of SEA reactive T cells , thereby suggesting a role of Fas Fas ligand interactions in the TCDD induced downregulation of SEA reactive T cell response . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , expression of CD 3 , CD 4 , and CD 8 molecules on TIL and Fas ligand ( FasL ) on the tumor was studied by immunohistochemistry . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although P 815 cells succumbed to recombinant Fas ligand ( FasL ) or isolated perforin / granzyme B , hepatic NK cells used only the granule pathway to kill this target . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , the antitumor effect was absent , and cytotoxic activity was significantly less ( P = 0 . 021 ) in gld mice ( Fas ligand deficient ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In HIVCM heart , active caspase 9 , a component of the mitochondrion controlled apoptotic pathway , and the elements of the death receptor mediated pathway , tumor necrosis factor alpha and Fas ligand , were expressed strongly on macrophages and weakly on cardiomyocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Namely , NK cells killed WEHI164S cells by perforin based cytotoxicity , TNFalpha mediated cytotoxicity , Fas ligand cytotoxicity , and other mechanisms , whereas intermediate T cells did so mainly by TNFalpha mediated cytotoxicity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Transduction of donor hematopoietic stem progenitor cells with Fas ligand enhanced short term engraftment in a murine model of allogeneic bone marrow transplantation . ^^^ We undertook studies to determine the outcome of lentiviral vector mediated transduction of Fas ligand ( FasL ) into lineage antigen negative ( lin ( ) ) mouse BM cells ( lin ( ) BMs ) , in an allogeneic BMT model . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It binds to Fas ligand ( FasL ) , LIGHT , and TL1A , all of which are TNF family members . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , AdTNFalpha therapy down regulated the expression of endothelial Fas ligand , a cell membrane protein implicated as a contributor to immune privilege in cancer . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Down regulation of these `` death ' ' receptors protects adenovirus infected cells from apoptosis induced by the death receptor ligands Fas ligand and TRAIL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activation of caspase 8 induced either by TNF or by Fas ligand expression was prevented by the R 1 protein . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Alteration of Fas and Fas ligand expression during human visceral leishmaniasis . ^^^ In this study , we show that patients with visceral leishmaniasis demonstrate significant dysregulation of Fas and Fas ligand . ^^^ Levels of soluble Fas ( sFas ) and soluble Fas ligand ( sFasL ) were elevated in plasma of patients with active visceral leishmaniasis ( VL ) and individuals co infected with VL HIV 1 compared to healthy controls . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Prevention of hepatocellular carcinoma development associated with chronic hepatitis by anti fas ligand antibody therapy . ^^^ Here , using a unique animal model of chronic hepatitis that induces hepatocellular carcinogenesis , we demonstrate that neutralization of the activity of Fas ligand prevented hepatocyte apoptosis , proliferation , liver inflammation , and the eventual development of hepatocellular carcinoma . ^^^ The results indicate that Fas ligand is involved not only in direct hepatocyte killing but also in the process of inflammation and hepatocellular carcinogenesis in chronic hepatitis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this study , we show that although IELs express CD 69 in situ and ex vivo , and have cytotoxic activity ex vivo , most CD 8 ( + ) IELs from normal mice are phenotypically similar to naive T cells in that they are CD45RB ( high ) , CD 44 ( low / int ) , and lack or have low levels of expression of CD 25 , Ly 6C , OX 40 , Fas ligand ( FasL ) , and intracellular IFN gamma synthesis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Previous studies have shown that ocular tissue also expresses functional Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Reduction of antiviral CD 8 lymphocytes in vivo with dendritic cells expressing Fas ligand increased survival of viral ( lymphocytic choriomeningitis virus ) central nervous system infection . ^^^ In vivo administration of APC expressing Fas ligand ( Fas L ( + ) dendritic cells ( DCs ) ) has shown promise in dampening allergic reactions and transplant rejection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
After sHLA 1 activating receptor interaction , NK cells produced and released Fas ligand ( FasL ) , which in turn led to NK cell apoptosis by interacting with Fas at the NK cell surface . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interferon gamma ( IFNgamma ) acts on human erythroid colony forming cells ( ECFCs ) to up regulate Fas , without a demonstrable change of Fas ligand ( FasL ) or Fas associated DD containing protein ( FADD ) expression and activates caspase 8 plus caspase 3 , which produce apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
For bone marrow cells cultured with Fas agonist or Fas antagonist , the percentage of cells with trisomy 8 was significantly decreased in most cases after Fas receptor triggering and increased by Fas ligand ( Fas L ) antagonist ( P < 0 . 01 ) , suggesting increased Fas susceptibility of cells with trisomy 8 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas mediates apoptosis following binding with Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand breaks tolerance to self antigens and induces tumor immunity mediated by antibodies . ^^^ The role of Fas ligand ( FasL ) in programmed cell death via interaction with its receptor Fas is well characterized . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas ligand activates the sphingomyelin pathway and induces apoptosis in luteal steroidogenic cells independently of stress activated p 38 ( MAPK ) . ^^^ Fas ligand ( FasL ) is implicated as a mediator of luteolysis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The molecular mechanisms whereby these CD4+ T cells lyzed their LMP2a expressing targets was investigated and we show that , although expressing Fas ligand on their surface , LMP2a specific CD4+ effector cells kill their targets using the Ca2+ dependent perforin / granzyme pathway which is the same mechanism used by CD8+ CTLs . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Aberrant Fas ligand expression in lymphocytes in patients with Behet ' s disease . ^^^ To further characterize the immune dysfunction and its contribution to the pathogenesis , we have studied Fas ligand ( FasL ) expression in peripheral blood lymphocytes ( PBL ) and mononuclear cells in the skin lesions in patients with BD . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : Using flow cytometry , we studied Fas receptor ( Fas R ) , Fas ligand ( Fas L ) , and interferon gamma ( IFN gamma ) expression in CD 34 ( + ) cells and lymphocytes obtained from 11 HMDS and 20 RA patients . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Previous reports have demonstrated the ability of antigen presenting cells ( APCs ) , genetically modified to express Fas ligand ( FasL ) , to inhibit T cell responses through the induction of apoptosis of antigen specific T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Aberrant expression of Fas ligand on anti DNA autoantibody secreting B lymphocytes in patients with systemic lupus erythematosus : `` immune privilege ' ' like state of the autoreactive B cells . ^^^ BACKGROUND : Fas / Fas ligand ( FasL ) system has been assigned a pivotal role in the development and maintenance of peripheral tolerance , and mice with defects in their Fas / FasL system develop lupus like symptoms . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and fas ligand are up regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome . ^^^ Apoptosis mediated by Fas / Fas ligand ( FasL ) interaction has been implicated in human disease processes , including pulmonary disorders . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis was triggered either by Fas ligand ( FasL ) or by tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) and was monitored by detection of cleavage of procaspase 8 and procaspase 3 , as well as their substrate poly ( ADP ribose ) polymerase ( PARP ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
On the other hand , treating HUVECs with Ox LDL did not lead to any significant change in the expression of death mediators , including Fas , Fas ligand ( FasL ) , FADD , and FLICE as assessed by multiplex polymerase chain reaction amplification . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The apoptotic ligands TRAIL , TWEAK , and Fas ligand mediate monocyte death induced by autologous lupus T cells . ^^^ Expression of the apoptotic ligands TRAIL , TNF like weak inducer of apoptosis ( TWEAK ) , and Fas ligand on lupus T cells was determined , and the role of these molecules in the monocyte apoptotic response was examined . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To determine the possible involvement of stimulators in ameloblast apoptosis , Fas , Fas ligand , tumor necrosis factor alpha , and tumor necrosis factor receptor 1 were examined utilizing immunohistochemistry and Western blotting analysis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To clarify the subcellular mechanisms of age associated dysregulation of apoptosis and the effects of CR , we analyzed the expression of genes promoting apoptosis ( p 53 , Fas receptor , Fas ligand , TNF receptor 1 , TNFalpha , Bax , TGF beta 1 ) and genes preventing apoptosis ( Bcl 2 and Bcl XL ) in the livers of 3 , 6 , 15 , and 24 month old male F 344 rats that were either fed ad libitum or subjected to a 30 % reduction in food intake ( CR ) . ^^^ After the age of 6 months , expression of p 53 , Fas receptor , Fas ligand , and TNFalpha mRNAs was up regulated with aging . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , Hg ( 2+ ) pretreatment did not increase the amount of apoptosis caused by apoptosis inducing agents that do not activate NF kappaB ( staurosporine , Fas ligand ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cytolytic activity of T cells is primarily mediated through the Fas Fas ligand and perforin granzyme pathways . ^^^ However , T cells deficient for both Fas ligand and perforin can still exert GVT activity in vivo in mouse models . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
PROTECTIVE MECHANISMS SHARED BY THE PLACENTA AND UTERUS : Protective mechanisms common both for placenta and uterus are as follows : expressions of Fas ligand prevention of infiltration of activated immune cells , regulation of immunosuppression which prevents proliferation of immune cells and high natural immunity ( Na cells and macrophages ) of the decidua . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , it was unknown whether imexon activates an intrinsic apoptotic pathway that is associated with activation of caspase 9 or an extrinsic pathway that is induced by receptor mediated signals such as Fas ligand characterized by caspase 8 activation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
With regard to Fas ligand , the expression was lower in unstimulated cultured mononuclear cells from patients than in normal individuals . ^^^ The Df stimulation upregulated the Fas ligand in patients with active asthma , and downregulated it in patients in remission . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We recently reported that the direct antitumor effectors in the liver induced by alpha galactosylceramide ( alpha GalCer ) are NK cells that are activated by the IFN gamma produced from NK1 . 1 Ag ( + ) T cells ( NKT cells ) specifically stimulated with alpha GalCer , whereas NKT cells cause hepatocyte injury through the Fas Fas ligand pathway . ^^^ An alpha GalCer injection also induced an age dependent increase in the Fas ligand expression on liver NKT cells . ^^^ Furthermore , liver mononuclear cells from old mice stimulated with alpha GalCer showed a more potent Fas Fas ligand mediated cytotoxicity against primary cultured hepatocytes than did those from young mice . ^^^ However , alpha GalCer induced hepatic injury did not improve at all by anti IFN gamma Ab treatment , and the Fas ligand expression of liver NKT cells did not change . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Induction of apoptosis was blocked by cyclosporin A , a caspase 3 inhibitor , and a mitogen activated protein kinase inhibitor , but not by Abs to either Fas ligand or to TNF alpha . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND & OBJECTIVE : It has been reported that apoptotic rate of tumor infiltrating lymphocytes ( TIL ) in Fas ligand ( FasL ) positive region was higher than in FasL negative region , which indicated that tumor cells could kill tumor infiltrating lymphocytes through high expressed FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 27 signalling in the T cells did not affect Fas ligand ( FasL ) mRNA expression , LAK activity and IFN gamma synthesis in humans . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Peripheral deletion is mediated in part by the activation of apoptosis by engagement of the death receptor , Fas ( CD 95 ) , by its ligand , Fas ligand ( FasL ; CD95L ) , among other mechanisms . ^^^ Nonlymphoid Fas ligand in peptide induced peripheral lymphocyte deletion . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recently , it has been shown that heritable mutations in Fas or Fas ligand genes , which regulate lymphocyte survival by triggering apoptosis of lymphocytes , are the most frequent cause of ALPS . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The death receptor and ligand , Fas and Fas ligand , are expressed in granulosa cells following gonadotropin withdrawal , culminating in caspase mediated apoptosis and follicular atresia . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Renal cell carcinoma ( RCC ) expresses Fas antigen on the cell surface , and thus could be sensitive to apoptosis induced by the binding of Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Nickel ( 2 ) induced apoptosis in murine T cell hybridoma cells is associated with increased fas ligand expression . ^^^ Preceding these morphological changes , nickel ( 2 ) treatment increased expression of Fas ligand ( FasL ) mRNA and protein levels and also increased caspase 3 like protease activity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The experiments examined the capacity of donor CD 8 T cells lacking Fas ligand and / or perforin function to facilitate donor B 6 congenic ( B 6 Ly5 . 1 ) BM engraftment across major histocompatibility complex class I / II barriers after transplantation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Identification of novel matrix metalloproteinase 7 ( matrilysin ) cleavage sites in murine and human Fas ligand . ^^^ Soluble Fas ligand ( sFasL ) is released from the cell surface by matrix metalloproteinases ( MMPs ) , one of which is MMP 7 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
One of the targets of forkhead transcription factors is the proapoptotic Fas ligand ( FasL ) gene . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Nasal natural killer ( NK ) / T cell lymphoma ( NL ) frequently co expresses Fas ( Apo 1 / CD95 ) and Fas ligand ( FasL ) , but the tumor cells seldom undergo apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas ligand and transforming growth factor beta 2 in the aqueous humor of patients with endothelial immune reactions after penetrating keratoplasty . ^^^ In animal models the secretion of transforming growth factor beta ( 2 ) ( TGF beta ( 2 ) ) into the anterior chamber and the expression of the Fas ligand on corneal endothelial cells were identified as important for the integrity of the immunological privilege . ^^^ OBJECTIVE : To determine the TGF beta ( 2 ) and soluble Fas ligand ( sFasL ) levels in the aqueous humor of patients after penetrating keratoplasty ( PK ) who have and who do not have immune reactions . ^^^ Soluble Fas ligand averaged ( mean [ SD ] ) 20 . 8 ( 31 . 1 ) pg / mL in group 2 , and 38 . 1 ( 33 . 2 ) pg / mL ( P < . 01 , analysis of variance ) in group 3 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Prognostic significance of a combination of soluble Fas and soluble Fas ligand in the serum of patients with Ta bladder cancer . ^^^ As circulating soluble Fas ( sFas ) and soluble Fas ligand ( sFasL ) have been implicated in protection from Fas mediated apoptosis against cancers and may interfere with immune surveillance against autologous cancers , sFas and sFasL in the serum of patients with Ta bladder cancer were evaluated as prognostic tumor markers for recurrence . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It binds to Fas ligand , LIGHT , and TL1A , all of which are TNF family members . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Porcine endothelial cells , unlike human endothelial cells , can be killed by human CTL via Fas ligand and can not be protected by Bcl 2 . ^^^ A granzyme B inhibitor peptide completely blocks anti human and partially blocks anti pig responses , while inhibitory Fas ligand Ab only blocks killing of porcine cells despite similar levels of Fas expression in both target cell types . ^^^ Bcl 2 effectively protects human EC rendered sensitive to Fas ligand by overexpressing Fas from huCTL , yet fails to protect porcine aortic endothelial cells from huCTL in the presence of anti Fas ligand Ab . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interestingly , the level of FasL mRNA in CTL clone remained unchanged following IL 2 treatment , whereas the level of expression of Fas ligand ( FasL ) on CTL surface was slightly enhanced . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RESULTS : Reverse transcription polymerase chain reaction indicated cisplatin induced up regulation of Fas , Fas ligand and TNF alpha mRNAs in the kidney in vivo and in RTCs in vitro , both in mice and rats . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Intracellular localization of keratinocyte Fas ligand explains lack of cytolytic activity under physiological conditions . ^^^ Acquired Fas ligand ( FasL ) mediated cytolytic activity of human keratinocytes causes the massive keratinocyte cell death that occurs during toxic epidermal necrolysis , a deadly adverse drug eruption . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Death ligands and receptors , such as tumor necrosis factor and Fas ligand , proapoptotic and antiapoptotic Bcl 2 family members and caspases have all been shown to participate in apoptosis regulation in the course of renal cell injury . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We found that FLICE associated huge protein ( FLASH ) , which transduces TNF alpha and Fas ligand signals , bound the NRB domain of GRIP 1 at a region between the second and third LXXLL motifs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Differential sensitivity of endothelial cells of various species to apoptosis induced by gene transfer of Fas ligand : role of FLIP levels . ^^^ BACKGROUND : Fas ligand expression by cells of the vessel wall has been proposed to play a role in normal and pathologic conditions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This study characterized the ability of a new member of the p 35 family , p 49 , to inhibit a number of mammalian and insect caspases . p 49 blocked apoptosis triggered by treatment with Fas ligand ( FasL ) , Tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) or ultraviolet ( UV ) radiation but provided negligible protection against apoptosis induced by the chemotherapeutic drug cisplatin . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Limited expression of Fas and Fas ligand in fetal nucleated erythrocytes isolated from first trimester maternal blood . ^^^ In the present study we evaluated the potential role of Fas and Fas ligand ( FasL ) cell surface expression with respect to apoptosis induction in fetal cells isolated from maternal blood . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand gene mutations in Hashimoto ' s thyroiditis . ^^^ To clarify whether Fas and Fas ligand ( FasL ) mutations are involved in the pathogenesis of Hashimoto ' s thyroiditis ( HT ) , we examined the open reading frame of Fas and FasL in 21 cases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Upon CD 40 engagement , BL cells are sensitized to T cell derived death signals provided by Fas ligand ( FasL , CD95L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL ) mediated apoptosis in the bone marrow may contribute to suppression of hematopoiesis in myelodysplastic syndromes ( MDS ) and in aplastic anemia , and also to the regulation of normal erythropoiesis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A role for the Fas / Fas ligand apoptotic pathway in regulating myeloid progenitor cell kinetics . ^^^ Bone marrow from wild type mice and mice with mutated Fas ( lpr ) or mutated Fas ligand ( gld ) was used to investigate the role of the Fas / FasL system in the regulation of myeloid progenitor cell kinetics . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We found that human epidermal keratinocytes exposed to a vesicating dose ( 300 microm ) of sulfur mustard ( SM ) exhibit a dose dependent increase in the levels of Fas receptor and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The mycotoxin penicillic acid inhibits Fas ligand induced apoptosis by blocking self processing of caspase 8 in death inducing signaling complex . ^^^ Upon engagement with Fas ligand ( FasL ) , Fas rapidly induces recruitment and self processing of caspase 8 via the adaptor protein Fas associated death domain ( FADD ) , and activated caspase 8 cleaves downstream substrates such as caspase 3 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Further analysis demonstrated that the activated androgen receptor blocked FKHR ' s DNA binding activity and impaired its ability to induce Fas ligand expression and prostate cancer cell apoptosis and cell cycle arrest . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( Apo 1 , CD 95 ) and Fas Ligand ( FasL , CD95L ) are typical members of the TNF receptor and TNF ligand family , respectively , with a pivotal role in the regulation of apoptotic processes , including activation induced cell death , T cell induced cytotoxicity , immune privilege and tumor surveillance . ^^^ Fas ( Apo 1 , CD 95 ) and Fas Ligand ( FasL , CD95L ) are typical members of the TNF receptor and TNF ligand family , respectively , with a pivotal role in the regulation of apoptotic processes , including activation induced cell death , T cell induced cytotoxicity , immune privilege and tumor surveillance . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Oxidative stress induces the expression of Fas and Fas ligand and apoptosis in murine intestinal epithelial cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Murine heart transgenic Fas ligand expression protects against allograft rejection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas , upon cross linking with Fas ligand ( FasL ) or Fas agonistic antibody , transduces apoptotic yet also proliferative signals , which have been implicated in tumor pathogenesis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interaction of the estrogen receptors with the Fas ligand promoter in human monocytes . ^^^ One important mechanism of cell survival is mediated by the Fas / Fas ligand ( FasL ) system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A novel polymorphic CAAT / enhancer binding protein beta element in the FasL gene promoter alters Fas ligand expression : a candidate background gene in African American systemic lupus erythematosus patients . ^^^ In luciferase reporter assays , the 844C genotype had twice the basal activity of the 844T construct , and basal expression of Fas ligand ( FasL ) on peripheral blood fibrocytes was also significantly higher in 844C than in 844T homozygous donors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Binding of Fas ligand to Fas induces apoptosis . ^^^ The Fas Fas ligand system plays important roles in many biological processes , including the elimination of autoreactive lymphoid cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODOLOGY : We studied 410 patients ( 166 African Americans and 244 Caucasians ) with a histologic diagnosis of pancreatic ductal adenocarcinoma of the usual type and analyzed ( a ) the clinicopathologic characteristics of the tumors , ( b ) the immunohistochemical expression of biomarkers implicated in pancreatic carcinogenesis ( Fas , Fas ligand , HER 2 , p21 / waf 1 , p 27 , and p 53 ) , and ( c ) the presence and types of K mutations at codon 12 as determined by polymerase chain reaction mediated amplification . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
AIMS : To address whether RCAS 1 is expressed in pancreatic cancer and whether serologic diagnostic evaluation is useful compared with that of carbohydrate antigen 19 9 ( CA 19 9 ) and soluble Fas ligand . ^^^ Serum soluble Fas ligand concentrations were not considerably different among these patients . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVE : Fas ligand ( FasL ) is a key cytokine which initiates apoptosis when FasL binds to its receptor , Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) related apoptosis inducing ligand ( TRAIL ) and Fas ligand ( FasL ) have been implicated in antitumor immunity and therapy . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Because Fas ligand ( FasL ) is highly expressed in the cornea , the role of this molecule in controlling corneal neovascularization was examined in this study . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Several studies have shown that immune privileged sites express Fas ligand ( FasL ) and induce apoptosis of activated T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Massive hepatic apoptosis associated with TGF beta 1 activation after Fas ligand treatment of IGF binding protein 1 deficient mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To study the effects of the interaction of the Fas system with p 53 in tumor progression and development , mice with a targeted disruption of the p 53 tumor supressor gene and a mutation in Fas ligand were bred . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Study on expression and function of fas ligand in human myeloid leukemia cells ] . ^^^ To determine whether the Fas receptor Fas ligand ( FasR FasL ) system , which triggers apoptosis in sensitive cells , is an important mechanism of cytotoxicity in myeloid leukemia . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The results suggest that it is possible to induce apoptosis of the allo antigen specific T cells in grafts activated by allo antigen by exogenous Fas ligand expressed on receptor cells and that may hopefully provide a new method to prevent GVHD . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunohistochemical study of Fas ligand in liver tissue of chronic hepatitis B virus infection ] . ^^^ To evaluate the role of apoptosis on liver injury of chronic hepatitis B , we studied the expression of Fas ligand and HBsAg immunohistochemically . ^^^ Sixty eight liver biopsy samples from patients with type B chronic liver disease were immunostained for Fas ligand and thirty two of which were immunostained for HBsAg . 35 / 68 ( 51 . 47 % ) cases showed FasL immunoreactive in liver infiltrating mononuclear cells , and more expression of FasL were found in cytoplasm of hepatocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of functional Fas ligand in choriocarcinoma . ^^^ Fas ligand ( FasL , CD95L , APO IL ) , a central regulator of the immune system , has been implicated in the maintenance of immune privileged sites , such as the eye , the testis and the pregnant uterus by inducing apoptosis in activated infiltrating leukocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Patient LTBMC stromal layers displayed pathologic interferon gamma and Fas ligand mRNA expression and failed to support normal myelopoiesis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas ligand ( FasL ) / Fas receptor ( CD 95 ) pathway is an important mediator of apoptosis in the immune system and can also mediate cancer cell death . ^^^ Inhibition of metalloproteinase cleavage enhances the cytotoxicity of Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : On the basis of comprehending several membrane proteins undergoing ectodomain shedding , including tumor necrosis factor ( TNF ) alpha receptors , we want to know if Fas ( CD95 / APO 1 ) , which belongs to the TNF receptor ( TNFR ) superfamily and transduces signals resulting in apoptosis upon binding of Fas ligand ( L ) or agonistic anti Fas antibody , is shed on its ectodomain during liver regeneration METHODS : After purification of the total membrane protein of hepatocytes , we analyzed Fas ectodomain shedding , using Western blotting , and determined the effect of Fas shedding on the apoptosis of hepatocytes by a statistical method relevant to apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Purified leukemic cells produce interleukin 12 ( IL 12 ) simultaneously with Fas ligand ( FasL ) and IL 6 , which may suppress T cell mediated immunity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interleukin 4 biases differentiation of B cells from Trypanosoma cruzi infected mice and restrains their fratricide : role of Fas ligand down regulation and MHC class 2 transactivator up regulation . ^^^ It is interesting that the protective effect of IL 4 over B cells from infected mice is mediated , at least partly , by the down regulation of Fas ligand ( FasL ) expression , which leads to interference in the apoptosis executed by these B cells through the Fas / FasL death pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
At the same time , Fas ( cg ) expression did neutralize the accelerating effect of transgenic Fas ligand expressed by the same beta cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This study was designed to investigate the correlation between the metastasis of hepatocarcinoma cell ( HCC ) to lymphnode and matrix metalloproteinases ( MMPs ) activity and the expression of Fas ligand of tumor cells in lymphnodes . ^^^ The expressions of Fas ligand of Hca F and Hca P cells in the mice were examined by immunohistochemistry . ^^^ The expression of Fas ligand of Hca F cells was stronger than that of Hca P cells ( P < 0 . 01 ) . ^^^ The increased expression of Fas ligand protein in Hca F tumor cells with high lymphogenous metastatic potential in lymph nodes may help tumor cells escape from being killed by host lymphocytes . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : We studied the expression of Fas antigen , Fas ligand ( FasL ) and hepatitis B virus ( HBV ) antigens ( HBsAg and HBcAg ) in the livers of 62 patients with hepatitis B using immunohistochemistry ABC method . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
ANG 2 also enhanced RPTEC expression of Fas and Fas ligand ( FasL ) ; furthermore , anti FasL antibody attenuated ANG 2 induced RPTEC apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis induced by ( E ) 5 ( 2 bromovinyl ) 2 ' deoxyuridine in varicella zoster virus thymidine kinase expressing cells is driven by activation of c Jun / activator protein 1 and Fas ligand / caspase 8 . ^^^ The findings also show that the drug causes the induction of c Jun and the activation of activator protein 1 resulting in increased level of Fas ligand ( FasL ) and caspase 8 / 3 activation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased salivary gland tissue expression of Fas , Fas ligand , cytotoxic T lymphocyte associated antigen 4 , and programmed cell death 1 in primary Sjgren ' s syndrome . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas and Fas ligand in lesions of patients with discoid lupus erythematosus ] . ^^^ METHODS : Expressions of Fas and Fas ligand ( FasL ) were detected in 30 lesions of discoid lupus erythematosus ( DLE ) and 5 skin specimens from healthy controls by immunohistochemical staining . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
By immunohistochemistry , we demonstrated increased expression of Fas , Fas ligand ( FasL ) , and bcl 2 on SMG epithelial cells of NOD and NOD scid mice , as early as 3 days of age . mRNA expression of Fas and FasL was also examined in SMG by RQ PCR . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand in pemphigus sera induces keratinocyte apoptosis through the activation of caspase 8 . ^^^ The Fas / Fas ligand system triggers the extrinsic apoptotic pathway and is involved in several inflammatory conditions , also at the skin level . ^^^ The Fas / Fas ligand cell death pathway plays a major role in anoikis , a type of apoptosis characterized by cell detachment . ^^^ As pemphigus is characterized by loss of cell to cell adhesion , we evaluated the role of anoikis and Fas ligand in this bullous disease . ^^^ Moreover , Fas ligand levels are markedly increased in sera from pemphigus patients , whereas they are undetectable in sera from patients undergoing steroid treatment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Bioactivities of culture supernatants from retroviral packaging cells carrying the mouse Fas ligand gene . ^^^ The bioactivities of culture supernatants from retroviral packaging cells carrying the mouse Fas ligand ( mFasL ) gene was investigated . ^^^ The biological activity of mFasL on NIH3T3 cells membrane was investigated by the inducing apoptosis of Fas+ Yac 1 cells co cultured with NIH3T3 cells expressing Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Annexin 5 binding and Fas ( CD 95 ) , Fas ligand ( FasL ; CD95L ) , and Bcl 2 expression in PB blasts were determined in newly diagnosed children with ALL before and 4 , 24 , 96 h after initiation of HDMP treatment ( n=20 ) or conventional dose steroids ( CDS ) ( n=10 ) as the control group . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Levels of apoptosis and Fas expression were measured using flow cytometry ; the soluble Fas ligand ( sFasL ) was also measured using the enzyme linked immunosorbent assay method , and the expression of FasL in PBMCs was observed using reverse transcriptase polymerase chain reaction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Failure of caspase 9 activation and cisplatin resistance was independent of the expression of p 53 , Bcl 2 family proteins , Fas receptor , and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here we report that epoxycyclohexenone ( ECH ) inhibits apoptosis induced by anti Fas antibody , Fas ligand ( FasL ) , or tumor necrosis factor alpha but not by staurosporine , MG 132 , C 2 ceramide , or UV irradiation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The membrane bound form of Fas ligand ( FasL ) signals apoptosis in target cells through engagement of the death receptor Fas , whereas the proteolytically processed , soluble form of FasL does not induce cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression was markedly elevated and caspase 3 activity increased by 3 fold in hemorrhagic untreated rats . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RESULTS : The genes , including MCP 1 , GADD 45 , Relaxin H 1 , CSF 1 , c jun oncogene , Pyk 2 , NKR P 2 and CREM , were significantly up regulated by both DTBHQ and antigen stimuli , whereas the genes including interleukin ( IL ) 3 , IL 4 , IL 9 , IL 13 , GADD 153 , butyrate response factor , and Fas ligand , were up regulated by DTBHQ alone . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas system is a mechanism through which cells expressing Fas ligand ( FasL ) induce apoptosis of Fas expressing cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Our objective has been to study the immunohistochemical expression of Fas and Fas ligand ( Fas L ) in order to determine whether the level of expression of these proteins could predict the outcome of the disease . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand gene polymorphisms are not associated with Hashimoto ' s thyroiditis and Graves ' disease . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The noticed phosphorylation dependent exclusion of FKHR from the nucleus impaired the ability of FKHR to activate its target Fas ligand promoter containing the FKHR binding motif ( FRE ) in cells treated with estrogen or expressing catalytically active Pak 1 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Quantitative analysis of lacrimal gland function , apoptotic figures , Fas and Fas ligand expression of lacrimal glands in dry eye patients . ^^^ The purpose of our study was to examine the correlation between the lacrimal gland function and apoptotic figure , Fas and Fas ligand ( FasL ) expression in the lacrimal gland . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Decoy receptor 3 ( DcR 3 ) is proteolytically processed to a metabolic fragment having differential activities against Fas ligand and LIGHT . ^^^ Fas ligand ( FasL ) and Fas receptor are members of the tumor necrosis factor ( TNF ) receptor and ligand family that play an important role in regulating apoptosis in normal physiology . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Alteration of the expression of Bcl 2 , Bcl 10 , Bax , Fas , and Fas ligand in the involved skin of psoriasis vulgaris following topical anthralin therapy . ^^^ On the other hand , hyperproliferative keratinocytes strongly expressed Fas ligand ( FasL ) on their plasma membranes as well as infiltrating lymphocytes in the upper dermis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In CNS derived lymphocytes , Fas ligand expression was down regulated in DNA vaccinated rats compared with controls . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Endothelial cell overexpression of fas ligand attenuates ischemia reperfusion injury in the heart . ^^^ Fas ligand ( FasL ) is a member of tumor necrosis factor family that induces apoptosis in target cells that express Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Modulation of apoptosis induced in U 937 or Jurkat cells by CD 95 ( Fas ligand ) or TNF alpha was measured using flow cytometry using the 7 AAD and annexin / propidium iodide methods . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Altered protein expression levels of Fas / CD95 and Fas ligand in differentially vulnerable brain areas in rats after global cerebral ischemia . ^^^ To assess the role of the apoptosis inducing death receptor Fas / CD95 and Fas Ligand ( FasL ) after global cerebral ischemia , expression of these proteins was investigated in differentially , i . e . selectively vulnerable brain areas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The intracellular mechanisms by which CORT acts on Leydig cells to induce apoptosis are unknown , and the present study tested for mediation by Fas ligand ( FasL ) , a member of the tumor necrosis factor ligand family , in association with caspase activation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of Bax , Bcl 2 , Fas and Fas ligand ( Fas L ) in human seminoma was evaluated and correlated with the apoptotic index . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The immunoprotective effect of Sertoli cells coencapsulated with islet xenografts is not dependent upon Fas ligand expression . ^^^ Here we investigate whether Fas ligand ( Fas L ) expression by testicular Sertoli cells is responsible for this additional protective effect . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Relation between circulating soluble Fas ligand and subsequent ventricular remodelling following myocardial infarction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Inhibition of TCR induced CD 8 T cell death by IL 12 : regulation of Fas ligand and cellular FLIP expression and caspase activation by IL 12 . ^^^ IL 12 decreased the number of Fas ligand positive CD 8 T cells and inhibited the activation of caspase 8 and caspase 3 . ^^^ These data suggest that IL 12 provides survival signals to CD 8 T cells by down regulating Fas ligand and up regulating cellular FLIPs , followed by inhibiting caspase activation , which implies a role for IL 12 in peripheral responses of CD 8 T cells in vivo . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
High expression of Fas ligand by synovial fluid derived gamma delta T cells in Lyme arthritis . ^^^ Cytolysis is largely Fas dependent and results from very high and prolonged expression of surface Fas ligand , which is transcriptionally regulated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The antitumor effects of anti CD 40 and IL 2 were found to be dependent on CD 8 ( + ) T cells , IFN gamma , IL 12 p 40 , and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here we explore to what extent the two main cytolytic pathways of CTL and NK cells , i . e . the granule exocytosis and the Fas ligand ( FasL ) / Fas pathways , are responsible for the elimination of parasites from mouse tissues and control of organ pathology . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The binding of sHLA A , B , C and sHLA G 1 molecules to CD 8 leads to Fas ligand ( FasL ) up regulation , soluble FasL ( sFasL ) secretion and CD 8 ( + ) cell apoptosis by Fas / sFasL interaction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
An enhancement in Fas / APO 1 and its two form ligands , membrane bound Fas ligand ( mFasL ) and soluble Fas ligand ( sFasL ) , as well as Bax protein , was responsible for the apoptotic effect induced by EGCG . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In vitro exposure of the human cell lines LNCaP and PC 3 and the mouse cell line RM 1 to agonist anti Fas antibody and / or soluble Fas ligand resulted in killing of only PC 3 cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( Fas L ) is a lethal cytokine that promotes apoptosis , as well as the immune and inflammatory responses through cross linking of the Fas receptor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas receptor and soluble Fas ligand ( sFasL ) concentration in acute leukemia ] . ^^^ Apoptosis mediated by the interaction of cytotoxic T lymphocyte with blast cell via Fas receptor / Fas ligand ( FasL ) pathway is a one of the mechanisms of immunological leukemia surveillance . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Administration of a neutralizing antibody against human TRAIL but not human TNF alpha or Fas ligand ( FasL ) blocked the neuronal apoptosis in the HIV 1 infected brain . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Nonviral genetic transfer of Fas ligand induced significant growth suppression and apoptotic tumor cell death in prostate cancer in vivo . ^^^ Since most PC cells express the apoptotic signal molecule Fas ( Apo 1 / CD95 ) on their surface , Fas ligand ( FasL ) gene was transferred into PC cells to kill the tumor cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Death receptors include tumor necrosis factor receptor 1 , Fas , death receptor ( DR ) 3 , DR 4 , DR 5 and DR 6 , whereas death ligands include tumor necrosis factor a , lymphotoxin , Fas Ligand , Apo 3 Ligand and TRAIL ( TNF Related Apoptosis Inducing Ligand ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Genetic investigations excluded mutations in Fas gene death domain and in the 4 exons of Fas ligand gene . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , no significant difference was found in the proportion of BAL lymphocytes positive for Fas ligand ( FasL ) between the two groups . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Before IL 2 culture , TIL showed undetectable or very low levels of T cell receptor ( TCR ) epsilon chain , p 56 ( lck ) , Fas ligand ( FasL ) and Bax expression , while Bcl 2 values were elevated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although concentrations of Bcl 2 , Bax , FLICE inhibitory protein ( FLIP ) , and Fas ligand were unaffected by MG 132 or actinomycin D , both treatments led to a significant increase of p 53 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Analysis of tumor immunosuppression factors in lymphocytes inside the tumor ( TCR zeta and epsilon chains , p 56 , FAS , and FAS ligand ) confirmed that the immunologic potential of TIL , depressed at the time of metastasectomy , was significantly restored after in vitro culture with IL 2 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CRH induces the expression of apoptotic Fas ligand ( FasL ) on invasive extravillous trophoblast and maternal decidual cells at the fetal maternal interface . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We examined the expression in cryostat sections of scalp skin obtained from a total of 28 patients with AA and from five normal control subjects of ( 1 ) molecules related to the induction of cell death including Fas , Fas ligand ( FasL ) , perforin , granzyme B ( GB ) , and TIA 1 , ( 2 ) molecules related to antigen presentation including CD1a , CD 40 , CD 54 , CD 80 , and CD 86 , and ( 3 ) molecules induced by interferon gamma ( IFN gamma ) including CD 40 , CD 54 , Fas , and HLA DR . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
High toxic concentration of DA ( 500 microM ) , R APO ( 50 microM ) , melatonin ( 50 microM ) , and EGCG ( 50 microM ) exhibited a similar profile of proapoptotic gene expression , increasing the level of bax , caspase 6 , fas ligand , and the cell cycle inhibitor gadd 45 genes , while decreasing antiapoptotic bcl 2 and bcl xL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD40LT also enhanced the capacity of CD 8 ( + ) T cells to lyse M . tuberculosis infected monocytes , and increased CTL activity was associated with higher expression of perforin and granulysin , but not of Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Hematopoietic progenitor cells from children with Fanconi anemia of the C complementation group ( FA C ) are excessively apoptotic and hypersensitive to various extracellular cues including Fas ligand , tumor necrosis factor alpha and double stranded RNA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL ) is well known to deliver a death signal through its receptor , Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In murine primary SS model , tissue infiltrating CD4+ T cells purified from the salivary glands bear a large proportion of Fas ligand ( FasL ) , and the salivary gland duct cells constitutively possess Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We believe the chronic inflammation present in obesity may predispose the obese to cancer through Fas receptor over expression and L selectin under expression in leukocytes , and elevated Fas ligand secretion in tumors affecting the morbidly obese . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Multiple mechanisms maintain ocular privilege , including the blood eye barrier , the lack of blood vessels and lymphatics in the normal cornea , the relative paucity of mature antigen presenting cells in the central cornea , the presence of immunomodulatory factors in ocular fluids , and the constitutive expressive of CD95L ( Fas ligand ) within the eye . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although enhanced CD 95 ( Fas ) expression has been observed 24 h post ECP , CD 95 and Fas ligand ( Fas L ) expression have not been determined at this very early apoptotic stage . ^^^ Treatment of cutaneous T cell lymphoma with extracorporeal photopheresis induces Fas ligand expression on treated T cells , but does not suppress the expression of co stimulatory molecules on monocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Sustained activation of JNK / p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells . ^^^ In the sensitive cells , inhibition of cisplatin induced JNK and p 38 activation blocked cisplatin induced apoptosis ; persistent activation of JNK resulted in hyperphosphorylation of the c Jun transcription factor , which in turn stimulated the transcription of an immediate downstream target , the death inducer Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand expression were not altered by treatment with camptothecin and / or Ad E2F 1 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These studies compared the apoptotic potential of various cytokines ( tumor necrosis factor alpha , TNFalpha ; interferon gamma , IFNgamma ; soluble Fas ligand , sFasL ) , a FAS activating antibody ( FasAb ) , and the luteolytic hormone prostaglandin F2alpha ( PGF2alpha ) on CL derived endothelial ( CLENDO ) cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Compartmentalization of Fas and Fas ligand may prevent auto or paracrine apoptosis in epithelial cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Human urinary bladder transitional cell carcinomas acquire the functional Fas ligand during tumor progression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This review focuses on novel strategies to induce apoptosis in glioma cells by transduction with adenoviral vectors carrying a variety of apoptosis related genes , including Fas ligand , Fas , FADD , caspase 8 , p 53 , p33ING1 , p73alpha , Bax , Apaf 1 , caspase 9 , IkappaBdN , caspase 3 , Bcl 2 , and Bcl 10 ( L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Display of Fas ligand protein on cardiac vasculature as a novel means of regulating allograft rejection . ^^^ BACKGROUND : Fas ligand ( FasL ) is a potent death inducing molecule with important functions in immune homeostasis and tolerance to self antigens . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increases in gamma interferon , FAS , FAS ligand , perforin , granzyme , and granulysin mRNA expression were associated with intracellular BCG inhibition . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVE : Fas ligand ( FasL ) is an important mediator of immune function and induces apoptosis by binding to its receptor Fas on sensitized cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Signaling and transcriptional control of Fas ligand gene expression . ^^^ Fas ligand ( FasL ) , a member of the tumor necrosis factor family , initiates apoptosis by binding to its surface receptor Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas ligand in sera was significantly elevated in all patients . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The immunohistochemistry and RT PCR assay showed a higher level of Fas expression and Fas mRNA in the cataracts with DR than in the senile cataracts , although there was no difference in the expression level of the Fas ligand , Bcl 2 , and their mRNAs between both groups . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis of leukemia cells induced by CD34+ cells transferred exogenous Fas ligand . ^^^ To assess the value of CD34+ cells transferred exogenous Fas ligand ( FasL ) in inducing apoptosis of human leukemic cells , the CD34+ cells transfected with FasL or without , pretreated with mitomycin C , was mixed with leukemic cell line U 937 cells in presence or absence of daunorubicin ( DNR ) or cytosine arabinoside ( Ara C ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas / Fas ligand reaction induced cytotoxic changes in tumor cells were evaluated by microculture MTT technique . ^^^ The Fas / Fas ligand induced apoptosis in tumor cells was studied by annexin 5 apoptotic cell expression and DNA ladder fragmentation analysis . ^^^ Apoptosis of TCC cells was observed during 48 h of treatment after activation of the Fas / Fas ligand pathway . ^^^ TNF alpha had a higher cytotoxicity activity on TCC cells than Fas ligand ( 17 vs . 0 . 7 % ) while combination of both reagents had 30 % increased synergistic cytotoxicity . ^^^ The increasing rate of apoptotic body after 3 days of treatment was 74 % in adriamycin , 32 % in Fas ligand , 60 % in TNF alpha , 69 % in Fas and adriamycin combination and Fas and TNF alpha combination , 103 % in combination of TNF alpha and adriamycin , and 136 % in combination of these three reagents individually . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The presence of HPV E 1 , E 2 , E 4 , E 5 , E 6 , E 7 , L 1 , and L 2 mRNAs and also transglutaminase 1 , involucrin , cyclin dependent kinases ( CDKs ) , cyclins , caspases , apoptosis inducing factor , DNase gamma , Fas , and Fas ligand mRNAs in HPV transfected cells was investigated by means of reverse transcription polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression and characterization of biologically active human Fas ligand produced in CHO cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We have previously demonstrated that a Fas Ligand ( FasL ) expressing adenovirus ( AdGFPFasL ( TET ) ) was able to induce Fas mediated apoptosis in a panel of PCa cell lines regardless of their Fas sensitivity as determined by the agonistic Fas antibody CH 11 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Different expression of Fas and Fas ligand in tumor infiltrating and peripheral lymphocytes of patients with renal cell carcinomas . ^^^ BACKGROUND : The presence of tumor infiltrating lymphocytes ( TIL ) in renal cell carcinomas ( RCC ) is thought to reflect a host mediated immune response against the tumor and the Fas / Fas ligand based lytic pathway is a major mechanism of T lymphocyte mediated cytotoxicity . ^^^ The aim of the present study was to investigate the expression of Fas and Fas ligand ( FasL ) in freshly isolated pure TIL as compared to autologous peripheral blood lymphocytes ( PBL ) , in order to determine their activation status . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The present study proposes a novel mechanism ( s ) by which VSMC become susceptible to Fas ligand . 4 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Our previous results showed that regulatory RNAs can induce the production of interleukin 1 , interleukin 2 , interleukin 8 , tumor necrosis factor alpha ( TNF alpha ) , interferon gamma , and Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Overexpression of Bcl 2 inhibited UVB induced apoptosis by blocking the early generation of reactive oxygen species , mitochondrial cardiolipin degradation and cytochrome c release , without affecting Fas ligand ( FasL ) induced cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Macrophages possess several mechanisms to kill tumor cells including TNF alpha , NO , reactive oxygen intermediates ( ROI ) , and Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis pathways can be triggered by surface receptors , which interact with soluble proteins or membrane bound proteins , such as Fas ligand . ^^^ Fas ligand accumulates in soluble form at sites of tissue inflammation and has the potential to initiate apoptosis of leukocytes , epithelial cells , and other parenchymal cells . ^^^ The effects of Fas ligand are modulated by factors in lung fluids , such as cytokines ( e . g . , transforming growth factor beta , surfactant protein A , and angiotensin 2 ) and a specific Fas ligand decoy receptor ( DcR 3 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RT PCR indicated cisplatin induced upregulation of Fas , Fas ligand , and TNF alpha mRNAs and complete inhibition by DMTU in vitro and in vivo . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Inhibition of the Fas ( CD 95 ) / Fas ligand ( CD95L ) signaling pathway with an antagonistic anti Fas antibody partially inhibited Aplidine induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although lower levels of p 53 did not induce apoptosis , the increase in death receptor expression was sufficient to render the oligodendrocytes susceptible to apoptosis in the presence of exogenous Fas ligand and TRAIL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Serum levels of soluble Fas ligand ( sFasL ) were normal , and granulocyte colony stimulating factor ( G CSF ) concentrations were either normal or raised . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : Tumor infiltrating macrophages secrete cytokines , including Fas ligand , tumor necrosis factor alpha ( TNF alpha ) , and TNF related apoptosis inducing ligand ( TRAIL ) . ^^^ Levels of TRAIL , TNF alpha , interferon alpha , and Fas ligand in conditioned medium were measured by enzyme linked immunosorbent assays . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Jejunal biopsies of 43 children with PCD and untreated ACD and 21 control samples were analyzed by means of standard indirect immunohistochemical technique for Fas , Fas ligand ( Fas L ) , tissue transglutaminase ( tTG ) , Bcl 2 , and glutathione S transferase ( GST ) expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We hypothesized that there is increased trophoblast apoptosis in chorioamnionitis and that this increased apoptosis is mediated by the Fas ligand ( FasL ) / Fas pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Downregulation of caspases and Fas ligand expression , and increased lifespan of neutrophils after transmigration across intestinal epithelium . ^^^ Transepithelial migration was found to delay neutrophil apoptosis , and this survival effect correlated with a downregulation of the surface expression of Fas ligand ( FasL ) and with a decrease in both procaspases 3 , and 8 mRNA and procaspases 3 , 6 , 7 and 8 protein levels . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , Fas ligand only induced apoptosis when administered together with morphine . ^^^ However , the sensitivity of the tumor cells toward Fas ligand remained low . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Consistent with the idea that MBD 4 can signal to an apoptotic effector , MBD 4 regulated DNA damage , Fas ligand , and cell detachment induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The issue of whether the Fas and Fas ligand ( FasL ) system and / or the Bax and Bcl 2 system is involved in the induction of germ cell apoptosis in normal and damaged testes will then be addressed , including a special consideration of the ischemia reperfusion model , the endocrine disruptor treated model , and others . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interleukin 12 p 40 and Fas ligand dependent apoptotic pathways involving STAT 1 phosphorylation are triggered during infection with a virulent strain of Toxoplasma gondii . ^^^ Induction of apoptosis was absent among all cell populations in both interleukin 12 ( IL 12 ) p 40 and Fas ligand ( FasL ) negative mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Vitamin D ( 3 ) up regulating protein 1 ( VDUP 1 ) antisense DNA regulates tumorigenicity and melanogenesis of murine melanoma cells via regulating the expression of fas ligand and reactive oxygen species . ^^^ The functional effect of VDUP 1 on B16F10 melanoma cells was demonstrated by reduction of Fas ligand and CD 44 expression in cells transfected with VDUP 1 antisense cDNA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of Fas ligand and activation induced cell death are major mechanisms by which immune responses are modulated in the lung . ^^^ Using murine activated CD4+ T cells and the T cell hybridoma DO11 . 10 , we found that RGD peptides inhibit tyrosine phosphorylation of CD 3 epsilon chain and ZAP 70 , clustering of T cell receptors , extracellular signal regulated kinase mitogen activated protein kinase activation , and Fas ligand expression and prevent activation induced cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Death associated protein ( DAP ) kinase is a pro apoptotic serine / threonine kinase with a death domain , which is involved in apoptosis induced by interferon gamma , tumor necrosis factor alpha , and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Western blot analysis showed that I / R induced expressions of platelet endothelial cell adhesion molecule 1 ( PECAM 1 ) and Fas and Fas ligand ( FasL ) proteins , cleaved Bid , and enhanced the release of cytochrome c from mitochondria to activate caspase 9 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NF AT activation by vGPCR depended upon signaling through the phosphatidylinositol 3 kinase Akt glycogen synthetase kinase 3 ( PI 3 K / Akt / GSK 3 ) pathway and resulted in increased expression of NF AT dependent cell surface molecules ( CD 25 , CD 29 , Fas ligand ) , proinflammatory cytokines ( interleukin 2 [ IL 2 ] , IL 4 ) , and proangiogenic factors ( granulocyte macrophage colony stimulating factor GMCSF and TNF alpha ) . vGPCR expression also increased endothelial cell T cell adhesion . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tamoxifen induces apoptosis in Fas+ tumor cells by upregulating the expression of Fas ligand . ^^^ In the current study , we investigated whether TAM induces apoptosis in tumor cells by altering the expression of Fas and Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The extrinsic pathway ( cell death receptor pathway ) is initiated by activation of the Fas receptor after binding to the Fas ligand ( Fas L ) ; increased Fas and Fas L expression has been shown following focal ischemia . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We first performed SBR or sham operations in mice , and the temporal expression of caspases 8 , 9 , and 3 , death receptors tumor necrosis factor receptor 1 ( TNFR 1 ) and Fas and corresponding ligands ( TNF and Fas ligand ) was determined in the remnant intestine at various postoperative time points . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To further explore the mechanisms underlying the development of chemoresistance in ovarian carcinoma after cisplatin ( CDDP ) treatment , we compared the effect of CDDP on expression of 10 linked inhibitor of apoptosis protein ( XIAP ) , a direct inhibitor of caspase 3 , 7 , and 9 , Fas , Fas ligand ( Fas L ) , and pro and antiapoptotic proteins in a CDDP sensitive human ovarian carcinoma cell line ( 2008 ) and its CDDP resistant subclone ( 2008C13 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RESULTS : Presence of tumour necrosis factor alpha , fas ligand , granzyme B and perforin mRNA in most of the liver biopsies reflected the occurrence of cell mediated immune reactions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Mechanisms of accelerated immune mediated diabetes resulting from islet beta cell expression of a Fas ligand transgene . ^^^ Nonobese diabetic ( NOD ) mice transgenic for Fas ligand ( FasL ) on islet beta cells ( HIPFasL mice ) exhibit an accelerated diabetes distinct from the normal autoimmune diabetes of NOD mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In human endometrial tissues , high Fas and Fas ligand expressions and Fas mediated apoptosis in endometrial epithelial cells have been discussed in many reports but no study has examined Fas mediated signals in endometrial stromal cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
An enhancement in Fas / APO 1 and its two form ligands , membrane bound Fas ligand ( mFasL ) and soluble Fas ligand ( sFasL ) , might be responsible for the apoptotic effect induced by tetrandrine . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We examined the impact of beta AR blockade with metoprolol on myocardial remodeling , apoptosis , pro apoptotic ( Fas , Fas ligand , Bax , and Bcl 10 ( S ) ) and anti apoptotic ( Bcl 10 ( L ) and Bcl 2 ) gene expression , and Bcl 10 ( L ) and Bcl 10 ( S ) protein in post infarction HF in rats . ^^^ However , Fas ligand mRNA and Bcl 10 ( S ) mRNA and protein , all undetectable in sham , were markedly elevated ( P < 0 . 001 ) , whereas Bcl 10 ( L ) mRNA and protein was unchanged . ^^^ Metoprolol treatment resulted in : ( 1 ) improved LV remodeling ( P < 0 . 025 ) , ( 2 ) reduced myocardial apoptosis ( P < 0 . 005 ) , and ( 3 ) selective reduction in myocardial Bcl 10 ( S ) expression ( P < 0 . 001 ) without change in Fas , Fas ligand , Bax , Bcl 2 , or Bcl 10 ( L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We report that Abeta ( 1 40 ) induced activation of JNK in CA 1 and that this was coupled with expression of the proapoptotic protein , Bax , cytosolic cytochrome c , poly ( ADP ribose ) polymerase cleavage , and Fas ligand expression in the hippocampus . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
High levels of Fas ligand and MHC class 2 in the absence of CD 80 or CD 86 expression and a decreased CD4+ T cell Infiltration , enables murine skin tumours to progress . ^^^ It has been hypothesized that tumour cells might evade immunological destruction by expressing Fas ligand ( FasL ) , a molecule which induces apoptosis in Fas ( + ) target cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We eliminated transforming growth factor beta ( TGF beta ) , Fas ligand ( FasL ) , and galectin family members as factors in SIS mediated T cell apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , KC express functional Fas ligand ( FasL ) and can induce apoptosis of Fas+ cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand are associated with neuritic degeneration in the AD brain and participate in beta amyloid induced neuronal death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Anti CD 2 mAb did not affect expression of Fas ligand and tumor necrosis factor ( TNF ) related apoptosis inducing ligand ( TRAIL ) by anti CD 3 activated T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODOLOGY : The expression of Fas , Fas ligand , and intracellular signaling molecules for apoptosis were determined by immunoblot analysis in fresh frozen liver samples from 19 patients with alcoholic liver disease . ^^^ RESULTS : Fas and Fas ligand expression was significantly increased in the liver of patients with alcoholic hepatitis ( n = 11 ) as compared with alcoholic liver disease patients without hepatitis ( n = 8 ) . ^^^ There were significant positive correlations between the Fas ligand and the FADD , ICE , or CPP 32 levels in the liver . ^^^ The expression of Fas , Fas ligand , FADD , ICE , or CPP 32 correlated with serum markers of hepatic injury . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Within 3 hours of ara G treatment , the levels of soluble Fas ligand ( sFasL ) in the medium increased significantly in CEM cultures . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This study evaluated in marrow mononuclear cells ( MNCs ) of patients with FA , the expression of negative modulators of the hematopoiesis , such as TNF alpha , IFN gamma , macrophage inflammatory protein 1alpha ( MIP 1alpha ) , and surface Fas ligand , and the role of TNF alpha on FA erythropoiesis in vitro . ^^^ MIP 1alpha and Fas ligand were undetectable in patients and controls . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In transient transfection experiments , this constitutively active ATF 2 mutant stimulated c jun , tumor necrosis factor alpha , and Fas ligand promoter activities . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
For example , while AICD in peripheral T cells is often caused by the induction of expression of the death ligand , Fas ligand ( CD 95 ligand , FasL ) , it does not appear to be involved in AICD in thymocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In comparison to lymphoid tissue , T cells in the periphery expressed lower levels of Fas and Fas ligand and were resistant to activation induced cell death in vitro . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Semi quantitative RT PCR revealed that expression of Fas ligand and tumor necrosis factor alpha ( TNF alpha ) mRNA in the uterus and vagina was increased by ovariectomy . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Mature but not immature Fas ligand ( CD95L ) transduced human monocyte derived dendritic cells are protected from Fas mediated apoptosis and can be used as killer APC . ^^^ To evaluate whether Fas ligand ( FasL / CD95L ) expressing killer APC could be generated from primary human APC , monocyte derived dendritic cells ( DC ) were transduced using the inducible Cre / Loxp adenovirus vector system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Conversely , in IL 12 treated IFN gamma deficient mice , other pathways of beta cell death appear to be increased , as indicated by the up regulated expression of Fas ligand on Th 1 cells in the absence of IFN gamma . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
After a 48 h incubation with Fas ligand , mean 28 . 5 % of brain motoneurons and 29 . 4 % of spinal motoneurons underwent apoptosis , with an inhibition by Z IETD FMK , a caspase 8 inhibitor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas ( sFas ) and soluble Fas ligand ( sFas L ) balance in laryngeal carcinoma before and after surgical treatment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
They express high levels of Fas and Fas ligand and undergo activation induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : To define whether immunosuppressive agents that block the interleukin ( IL ) 2 pathway could prevent activation induced cell death of activated T cells in the graft , we measured expression of IL 2 , IL 2 receptor alpha chain ( CD 25 ) , IL 15 , Fas , and Fas ligand by real time reverse transcription polymerase chain reaction in cardiac allografts . ^^^ Inhibition of the IL 2 pathway by anti CD 25 mAb therapy was accompanied by reduced mRNA and protein of Fas ligand and not by reduced Fas expression ( P=0 . 001 and P=0 . 03 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas ligand ( sFasL ) in the CSF was measured by ELISA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Mutational analysis of Fas ligand gene in human non Hodgkin lymphoma . ^^^ Among the systems triggering apoptosis , the Fas Fas ligand ( FasL ) system is recognized as a major pathway for the induction of apoptosis in cells and tissues . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand downregulation with antisense oligonucleotides in cells and in cultured tissues of normal skin epidermis and basal cell carcinoma . ^^^ Fas ligand ( FasL ) , a member of the tumor necrosis factor family , induces apoptosis upon interaction with Fas receptor expressing cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
They illustrate the role of Fas and Fas ligand in the control of autoimmune T cell and B cell proliferation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Silica can also initiate apoptosis in response to oxygen and nitrogen based free radicals , leading to mitochondrial dysfunction , increased gene expression of death receptors , and / or their ligands ( TNFalpha , Fas ligand [ FasL ] ) . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OVA specific CD4+ T cells that survived apoptosis in the liver expressed Fas ligand and secreted IL 4 , IL 10 , and transforming growth factor beta ( 1 ) . ^^^ In addition , significant suppression of delayed type hypersensitivity and IgG ( 1 ) / IgG ( 2a ) responses to OVA was observed in the recipients of hepatic CD4+ T cells , and this suppression required Fas / Fas ligand interaction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Surprisingly , the apoptosis inducing activity of HMC 1 mast cells was not mediated by known tumor necrosis factor ( TNF ) superfamily members ( TNF alpha , Fas ligand , TRAIL , TWEAK ) , nor did the fragmentation of Jurkat cell DNA by mast cells require the activity of caspase 3 , 8 , or 9 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand mRNA and protein expression were increased by the treatment with NS 398 ( 10 micro M ) in COX 2 expressing cell lines . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL ) , that has the inherent capacities to tether the T cell inhibitor FasL ( CD 95 ligand ) to the surfaces of B 7 ( CD 80 and CD 86 ) positive APC ( via CTLA 4 : B 7 interaction ) , and in so doing , to simultaneously interfere with B 7 to CD 28 T cell activation signals . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Endogenous decoy receptor 3 blocks the growth inhibition signals mediated by Fas ligand in human pancreatic adenocarcinoma . ^^^ DcR 3 is a soluble receptor against Fas ligand belonging to the tumor necrosis factor receptor superfamily and overexpresses in some forms of cancers . ^^^ Four of 7 pancreatic cancer cell lines were inhibited from growing , compared to control cells , when cocultured with membrane bounded Fas ligand ( mFasL ) transfected lymphomas for 48 hr after pretreatment with IFNgamma . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Further analyses revealed that Fas ligand ( FasL ) positive T cells were observed exclusively among T cells that divided at least 5 times , and that all of them were positive for Annexin 5 , indicating that they were in the process of apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In order to investigate pathways of apoptosis in mouse uterine epithelium and decidua during early pregnancy ( day 4 . 5 7 . 0 post coitum ) , we have investigated different proteins such as TNFalpha , TNF receptor 1 , Fas ligand , Fas receptor 1 , Bax and Bcl 2 as well as caspase 9 and caspase 3 using immunohistochemistry . ^^^ In the developing decidua the Fas ligand , but not the Fas receptor , was expressed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas / Fas ligand , Bcl 2 protein and apoptosis in extravillous trophoblast along invasion to the decidua in human term placenta . ^^^ In order to elucidate the potential role of apoptosis along the invasion of EVT to the decidua , we have assessed the expression of apoptosis regulating proteins including Fas antigen ( Fas ) , Fas ligand ( Fas L ) and Bcl 2 protein , and apoptosis in the proliferative phenotype of EVT and the invasive phenotype of EVT in term ( 37 to 38 wk ) placenta Fas , Fas L and Bcl 2 protein expression were examined by avidin / biotin immunoperoxidase method . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Upon activation , by either binding with Fas ligand or self aggregation , Fas signaling leads to cell apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Receptor activation with Fas ligand for 30 min increased the amplitude of voltage activated potassium currents 2 fold on average . ^^^ This produces a sustained outward current , approximately 10 pA , at physiological membrane potentials during Fas ligand induced apoptosis . ^^^ Both basal and Fas ligand induced currents were blocked completely by toxins that selectively inhibit Kv1 . 3 potassium channels . ^^^ Furthermore , Kv1 . 3 stimulation by Fas ligand was prevented by chronic stimulation of protein kinase C with 20 nm phorbol 12 myristate 13 acetate during Fas ligand treatment , which also blocks apoptosis . ^^^ Thus , Fas ligand increases Kv1 . 3 channel activity through the same canonical apoptotic signaling cascade that is required for potassium efflux , cell shrinkage , and apoptosis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Protection of hepatocytes by caspase 8 siRNA significantly attenuated acute liver damage induced by agonistic Fas ( CD 95 ) antibody ( Jo 2 ) or by adenovirus expressing Fas ligand ( AdFasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We measured soluble Fas ligand ( sFasL ) and anti Fas antibodies levels , two potent inducers of the Fas signalling pathway leading to apoptosis , in CSF from African trypanosomiasis patients and controls . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Quantitative analysis of Fas and Fas ligand mRNAs in a feline T lymphoid cell line after infection with feline immunodeficiency virus and primary peripheral blood mononuclear cells obtained from cats infected with the virus . ^^^ In this study , to investigate the mechanism of FIV induced apoptosis , levels of Fas and Fas ligand mRNAs were measured by real time reverse transcription PCR . ^^^ In a feline T lymphoid cell line the amounts of Fas ligand mRNA increased along with the induction of apoptosis after in vitro infection with FIV . ^^^ In PBMC collected from 10 cats naturally infected with FIV , Fas ligand mRNA levels were significantly higher than those in PBMC from five uninfected cats . ^^^ These results indicate that the increased expression of Fas ligand may be involved in the induction of apoptosis of lymphocytes in FIV infection . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In particular , Fas and Fas ligand ( FasL ) interactions are known to control the development of `` sunburn cells ' ' or apoptotic keratinocytes in the UV exposed epidermis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis and increased expression of Fas ligand after uniocular anterior chamber ( AC ) inoculation of HSV 1 . ^^^ PURPOSE : To determine if apoptosis occurs in the eyes and brain following uniocular anterior chamber ( AC ) inoculation of HSV 1 and if expression of Fas ligand ( FasL ) or Fas is altered by virus infection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Thy 1 stimulated T cells adhere to target cells and express perforin , granzyme B , and Fas ligand , but fail to kill target cells due to an inability to reorganize their secretion machinery . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Differential effects of membrane and soluble Fas ligand on cardiomyocytes : role in ischemia / reperfusion injury . ^^^ Cardiomyocyte apoptosis by Fas ligand ( FasL ) / Fas signaling is associated with various pathophysiological conditions , such as ischemia / reperfusion injury and congestive heart failure . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
FK 506 restores sensitivity of thymic lymphomas to calcium mediated apoptosis and the inducible expression of Fas ligand . ^^^ Here we show that Fas ligand ( FasL ) induction is also abrogated in thymic lymphomas treated with ionomycin but not with etoposide , which still induced the expression of FasL and Fas receptor as well as apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression in cervical adenocarcinoma : relevance to lymph node metastasis and tumor progression . ^^^ Fas ligand ( FasL ) could allow the tumor cells to evade host immune surveillance and would thus promote tumor survival and possibly metastasis formation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Gastric T cell apoptosis and Fas ligand expression were examined by flow cytometry after experimental infection of rhesus macaques with H . pylori . ^^^ Fas ligand expression showed a similar transient induction , suggesting that it mediates gastric T cell apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This study of 53 MM patients demonstrates an enhancement of osteoblast cytotoxicity by malignant myeloma cells via the upregulation of apoptogenic receptors , including Fas ligand ( Fas L ) and tumour necrosis factor related apoptosis inducing ligand ( TRAIL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased retinal neovascularization in Fas ligand deficient mice . ^^^ PURPOSE : To investigate whether the absence of the Fas Fas ligand system of apoptosis regulation affects hyperoxia induced retinal vaso obliteration and retinal neovascularization in a mouse model of oxygen induced retinopathy . ^^^ METHODS : C57BL / 6 ( B 6 ) and congenic Fas ligand deficient generalized lymphoproliferative disease ( gld ) mice were exposed to 75 % oxygen from postnatal day ( P ) 7 to P 12 and then allowed to recover in room air . ^^^ RT PCR was used to examine retinal expression of Fas and Fas ligand ( FasL ) over a time course of hyperoxia induced retinopathy . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Xenotransplantaion of islet from fas ligand transgenic mice in experimental diabetic rat . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas mediated apoptosis has also been implied in the mechanism of hepatocyte apoptosis upon allogenic hepatocyte transplantation ( HTx ) , and blockade of Fas and Fas ligand interaction successfully promotes the repopulation of allogenic liver cells in recipient spleens . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although caspase 8 is known to be involved in death receptor dependent apoptosis , measurable caspase 8 activity or even RGC death could be induced by neither tumor necrosis factor alpha nor Fas ligand injections into unlesioned eyes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression is correlated with metastasis in colorectal carcinoma . ^^^ The Fas / Fas ligand ( FasL ) system is one apoptotic pathway through which malignant tumors can evade immune surveillance . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We investigated the cellular and molecular factors participating in modulation of immune response in peripheral nerves , focusing on two cytotoxic pathways : fas ligand ( fasL ) and perforin . fasL and perforin expression was found by immunochemistry on Schwann cells ( Sc ) in nerve biopsies from patients with chronic inflammatory demyelinating polyneuritis and on human Sc cultures . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
During luteolysis , luteal cell apoptosis is induced by the Fas ligand ( FasL ) / Fas system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Caspase 8 , one of the initiator caspases , plays an important role in the Fas Fas ligand pathway . ^^^ In this study , we evaluated the sensitivity of a series of human neuroblastoma cell lines to membrane bound Fas ligand induced cell death , as well as the expression of Fas , caspase 3 and caspase 8 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of apoptosis related proteins such as Fas ligand and perforin was also investigated . ^^^ A decrease of Fas ligand and perforin in the estrogen treated CTLL / MfasER was seen in an immunoblot analysis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Study on the expression of Fas ligand on the surfaces of human cytotrophoblasts in normal pregnancy . ^^^ To further study the mechanism of maternal fetal immune tolerance , the expression of Fas ligand ( FasL ) on the surfaces of human cytotrophoblasts in normal pregnancy was detected by using immunohistochemical method . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The two cells expressed Fas and Fas ligand , and the Fas of G 1 2 was functional but that of M 2 10 was not . ^^^ The treatment of these cells with anti Id resulted in no change in Fas ligand and Bax expression , but the expression of Bcl 2 was decreased . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This de novo alendronate resistance was accompanied by resistance to another N BP ( zoledronate ) but not to an inhibitor of 3 hydroxy 3 methylglutaryl CoA reductase or Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A Bcl 2 transgene expressed in hepatocytes does not protect mice from fulminant liver destruction induced by Fas ligand . ^^^ In contrast , Fas ligand ( FasL ) induced death can not be overcome in bcl 2 transgenic mice , indicating that anti Fas antibodies do not reliably mimic the more physiological ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand and caspase 3 contributes to formation of immune escape in gastric cancer . ^^^ AIM : To study the role of Fas ligand ( FasL ) and Caspase 3 expression in carcinogenesis and progression of gastric cancer and molecular mechanisms of relevant immune escape . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here we first report that human recombinant FasDeltaTM , i . e . soluble Fas generated by alternative splicing of the intact exon 6 , is capable of inducing death of transformed cells by `` reverse ' ' apoptotic signaling via transmembrane Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Previous studies demonstrate CD 28 mediated enhancement of the transcription and expression of Fas ligand ( CD95L ) in T cell lines , suggesting a regulatory link between CD 28 and CD95L expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Our first paradigmatic inhibitory TSCP , CTLA 4 * Fas ligand , binds to APC , and in so doing , simultaneously blocks B 7 costimulation ( via CTLA 4 ) and sends inhibitory trans signals ( via Fas ligand ) to T cells with dramatic efficacy . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , the expression of Bax , Fas and Fas ligand mRNA and proteins ( promoters of apoptosis ) in cardiomyocytes was significantly increased in SAD rats . 5 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Encouraging attempts have been made with plasmapheresis , indomethacin , low dose cyclophosphamide , anti CTLA 4 , anti FAS ligand and , perhaps in the future , more judiciously applied chemotherapy . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To this end , graft manipulation to reduce the presence of Fas Ligand ( FasL ) expressing cells or interleukin ( IL ) 10 and tumor growth factor ( TGF ) beta production has been proposed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Mutation in fas ligand impairs maturation of thymocytes bearing moderate affinity T cell receptors . ^^^ Fas ligand , best known as a death inducer , is also a costimulatory molecule required for maximal proliferation of mature antigen specific CD4+ and CD8+ T cells . ^^^ We now extend the role of Fas ligand by showing that it can also influence thymocyte development . ^^^ T cell maturation in some , but not all , strains of TCR transgenic mice is severely impaired in thymocytes expressing mutant Fas ligand incapable of interacting with Fas . ^^^ Mutant Fas ligand inhibits neither negative selection nor death by neglect . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas ( CD95 / Apo 1 ) , soluble Fas ligand , and activated caspase 3 in the cerebrospinal fluid of infants with posthemorrhagic and nonhemorrhagic hydrocephalus . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
As RBC supernatants failed to mobilize intracellular free calcium , the chemoattractants should belong to the group of pure chemoattractants , that is , soluble Fas ligand ( sFasL ) and transforming growth factor beta 1 ( TGF beta 1 ) , known to act without increasing calcium levels . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand on tumor cells mediates inactivation of neutrophils . ^^^ The expression of Fas ligand ( FasL ) on tumor cells ( tumor FasL ) has been implicated in their evasion of immune surveillance . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although neither perforin nor Fas ligand expression was required for GVHD enhancement , donor IFN gamma production was required for optimal GVHD acceleration in the absence of PD 1 ligation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In vivo human : correlation of plasma creatinine and soluble Fas ligand . ^^^ The Fas : Ig , a fusion protein that blocks soluble Fas ligand , attenuated induction of apoptosis in vitro . ^^^ There was a significant correlation between changes in soluble Fas ligand and changes in creatinine in patients with ARDS ( R = 0 . 64 , P = . 002 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It also induces Fas ligand expression , activates procaspases 8 and 9 cleavage , reduces mitochondrial membrane potential , and increases cell death ( as determined by propidium iodide staining ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Perforin , granzyme B , and Fas ligand were only observed before IVIG administration . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
KG1a cells ( CD34+ / 38 ) express FAS and TRAIL ( tumour necrosis factor related apoptosis inducing ligand ) receptors but are resistant to FAS ligand and TRAIL / APO2 L ( apoptosis antigen 2 ligand ) induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Administration of an antigen ( Ag ) per oral route leads to apoptosis of Ag specific CD 4 ( + ) T cells and to development of Th 2 cells expressing Fas ligand ( FasL ) in the liver . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunofluorescence staining together with ordinary and confocal microscopy confirmed the observations that procaspase 3 immunoreactivity was clearly identified in the cytoplasm and nucleus while Fas ligand staining was localized to the cell surface and PARP immunoactivity to the nucleus , which were used as controls ; procaspase 3 exhibited granular nuclear immunoreactivity whereas PARP displayed diffuse nuclear immunoreactivity ; both of which was more intense in the internucleolar regions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Similar processing occurs in TNF , LPS , Fas ligand , and thapsigargin ( Tg ) induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , POH treatment induced a transient G ( 2 ) / M arrest , enhanced the expression of the membrane bound form of the Fas ligand and sensitized the cells to Fas mediated apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of mutant non cleavable Fas ligand on retrovirus packaging cells causes apoptosis of immunocompetent cells and improves prodrug activation gene therapy in a malignant glioma model . ^^^ Murine fibroblast derived VPC expressing herpes simplex virus type 1 thymidine kinase ( HSV tk ) were genetically modified to co express a human Fas ligand ( CD95L ) deletion mutant ( DeltaFasL ) resistant to enzymatic cleavage and shedding . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Factors like cytokines , prostaglandine , microbes , MHC molecules , hormones , Fas ligand , heat shock proteins , phenotypes of dendritic cells and APCs , probably can be polarizing courses of eTLM pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : We used magnetic bead based purification and flow cytometry to study several aspects of normal human small bowel natural killer like intraepithelial lymphocytes : intracellular cytokine content ( basally and after activation ) ; ability to lyse natural killer sensitive K 562 target cells ; and expression of perforins , Fas ligand , and other functional markers . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
MRL Tnfrsf 6 ( lpr ) mice and Fas ligand deficient C3H / HeJ Tnfsf 6 ( gld ) mice are relatively resistant to the induction of alopecia areata by grafting of alopecia areata affected skin from C3H / HeJ mice . ^^^ Alopecia areata is suspected to be a T cell mediated autoimmune disease of the hair follicle , where Fas is expressed on hair follicles and Fas ligand on perifollicular infiltrates . ^^^ To elucidate whether the Fas / Fas ligand pathway is of pathogenetic significance in alopecia areata , we investigated whether alopecia areata can be induced in Fas deficient and Fas ligand deficient mice and whether alopecia areata develops in Fas deficient and Fas ligand deficient skin . ^^^ Therefore , we induced alopecia areata by grafting alopecia areata affected C3H / HeJ mouse skin on to C3H / HeJ mice ( control ) , on to Fas ligand deficient C3H / HeJ Tnfsf 6 ( gld ) mice or Fas deficient C3 . ^^^ All control mice developed alopecia areata , whereas no Fas deficient mice showed hair loss and two of seven Fas ligand deficient mice developed only transitory , limited alopecia areata . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Bone marrow cell transfer of autoimmune diseases in a MRL strain of mice with a deficit in functional Fas ligand : dissociation of arteritis from glomerulonephritis . ^^^ MRL / MpTn gld / gld ( MRL / gld ) mice , which are deficient in a functional Fas ligand ( FasL ) , spontaneously develop autoimmune diseases involving both lethal glomerulonephritis and systemic arteritis , while MRL / Mp + / + ( MRL / + ) and C3H / HeJ gld / gld ( C3H / gld ) do not . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A recent report suggested that TRAIL was a critical factor in this process , a result that does not fit well with previous studies that excluded a role for the FADD caspase 8 pathway , which is essential for TRAIL and Fas ligand ( FasL ) signaling , in negative selection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Serum levels of soluble Fas ligand and soluble Fas receptor in patients with chronic congestive heart failure . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Resveratrol does not modulate the expression of Fas and Fas ligand ( FasL ) at the surface of cancer cells , and inhibition of the Fas / FasL interaction does not influence the apoptotic response to the molecule . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activation induced cell death or CD 8 ( + ) T cells failed to account for the enhanced apoptosis as infected Fas , Fas ligand , and CD 8 deficient mice exhibited similar apoptosis to that seen in wild type counterparts . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Pathogen associated molecular patterns sensitize macrophages to Fas ligand induced apoptosis and IL 1 beta release . ^^^ In this study , we demonstrated that various pathogen associated molecular patterns up regulated Fas expression in macrophages and sensitized them specifically to Fas ligand ( FasL ) , but not to other apoptosis inducing agents such as TNF alpha , etoposide ( VP 16 ) , and staurosporine . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The effects of tumor immunosuppression in lymphocytes inside the tumor ( TCR z and e chains , p56lck , FAS and FAS ligand ) confirmed that the potential function of TIL , immunodepressed at the time of metastasectomy , was significantly restored after in vitro , culture with IL 2 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The tumor necrosis factor ( TNF ) family comprises several ligands , such as the prototype TNF alpha , the Fas ligand ( FasL ) and TNF related apoptosis inducing ligand ( TRAIL / Apo2L ) , which trigger apoptosis in susceptible cells by activating respective cell surface receptors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression in the organ of Corti . ^^^ We have previously demonstrated by FACS analysis and histochemistry that Fas ligand ( FasL ) increases on cochlear cell surfaces after immune response or stimulation with gamma interferon ( IFN gamma ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand mRNA expression and protein levels increased significantly after repair inhibition . ^^^ Neutralizing antibodies against Fas or Fas ligand significantly reduced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We further established that both transient and constitutive HRT 1 signaling promoted VSMC survival in response to serum deprivation and pro apoptotic Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas ligand levels in cerebrospinal fluid in neuro Behet ' s disease . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptotic cell death may be induced by either cytotoxic T cells through the release of proteases , such as perforin and granzyme B , or the interaction of Fas ligand ( FasL / CD95L ) , expressed by T lymphocytes , with Fas ( Apo 1 / CD95 ) on epithelial cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand , but not Fas receptor , expression on D . farinae stimulated cells was up regulated after stimulation with 1 microg / ml roxithromycin , while Bcl 2 expression on both unstimulated and D . farinae stimulated cells showed a decrease after the same treatment . ^^^ Induction of the Fas / Fas ligand system and reduced Bcl 2 expression were involved in the promotion of apoptosis by roxithromycin treatment . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas / Fas ligand pathway is important for optimal tumor regression in a mouse model of CTL adoptive immunotherapy of experimental CMS 4 lung metastases . ^^^ If CTL do mediate tumor regression in vivo by direct cytotoxicity , this may occur via two major effector mechanisms involving the secretion of perforin / granzymes and / or engagement of Fas by Fas ligand ( FasL ) expressed by the activated CTL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , mice and humans with homozygous Fas ( lpr ) or Fas ligand ( gld ) mutations develop significant numbers of B220+ CD 4 CD 8 double negative ( DN ) alphabeta T cells ( hereafter referred to as B220+ DN T cells ) of poorly understood function . ^^^ Furthermore , restoration of Fas / Fas ligand interaction did not enhance suppression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand is not constitutively expressed in low grade B cell lymphoma and B lymphoblastoid cells . ^^^ The Fas ligand ( FasL ) pathway is one of the two major effector mechanisms of T cell mediated cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Higher susceptibility to Fas ligand induced apoptosis and altered modulation of cell death by tumor necrosis factor alpha in periarticular tenocytes from patients with knee joint osteoarthritis . ^^^ The aim of the present study was to investigate the expression of Fas in periarticular tenocytes of patients with osteoarthritis ( OA ) and to study their susceptibility to Fas ligand mediated apoptosis . ^^^ Apoptosis was induced with recombinant human Fas ligand and measured by a histone fragmentation assay and flow cytometry . ^^^ OA tenocytes were significantly more susceptible to Fas ligand induced apoptosis than were control cells . ^^^ TNF alpha reduced the Fas ligand induced apoptosis in OA tenocytes but had no effects on control tenocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Both the Fas ligand and inducible nitric oxide synthase are needed for control of parasite replication within lesions in mice infected with Leishmania major whereas the contribution of tumor necrosis factor is minimal . ^^^ We show here that C57BL / 6 mice lacking both TNF and Fas ligand ( FasL ) ( gld TNF ( / ) mice ) infected with L . major neither resolved their lesions nor controlled Leishmania replication despite the development of a strong Th 1 response . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( Fas L ) expression was induced on intrahepatic NK1 . 1 ( + ) T cells in vivo after an intraperitoneal inoculation of Escherichia coli . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : Reverse transcription polymerase chain reaction ( RT PCR ) and immunohistochemistry ( IHC ) allowed the determination of Fas , Fas ligand ( FasL ) , and bcl 2 mRNA expressions in surgically resected tissues of 40 cases of RCC . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Lyn regulates the cell death response to ultraviolet radiation through c Jun N terminal kinase dependent Fas ligand activation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This unbridled calcineurin activity drove Fas ligand expression , which normally requires high T cell receptor stimulation and results in the premature death of T helper type 1 cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In additional studies , using gld and lpr ( cg ) mice , which harbor loss of function mutations in Fas ligand ( FasL ) and Fas , respectively , we demonstrated that heat induced germ cell apoptosis is not blocked , thus providing further evidence that the Fas signaling system is dispensable for heat induced germ cell apoptosis in the testis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Since various pathways required for intrinsic apoptosis are often inactivated in melanoma , we used Fas ligand ( FasL ) overexpression to promote extrinsic apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , tumor specific CD 8 cells in 1628 did not show enhanced antitumoral cytotoxicity when analyzing lymphocyte tumor cell co cultures or transcription of the cytotoxic CD 8 cell associated molecules interferon gamma , FAS ligand , perforin , or granzyme B by quantitative real time RT PCR . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We previously reported that treatment of human vascular smooth muscle cells ( SMCs ) with proapoptotic stimuli , including Fas ligand plus cycloheximide ( FasL / Chx ) , or overexpression of Fas associated death domain protein ( FADD ) result in increased expression of monocyte chemoattractant protein 1 ( MCP 1 ) and other proinflammatory genes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expressed in colon cancer is not associated with increased apoptosis of tumor cells in vivo . ^^^ Expression of Fas ligand ( FasL / CD95L ) may help to maintain colon cancers in a state of immune privilege by inducing apoptosis of antitumor immune effector cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand and tumour counter attack in colorectal cancer stratified according to microsatellite instability status . ^^^ Expression of membrane bound Fas ligand ( FasL ) by colorectal cancer cells may allow the development of an immune privileged site by eliminating incoming tumour infiltrating lymphocytes ( TILs ) in a Fas mediated counter attack . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We have shown that the low BM CD34+ cell number in SLE is due to at least in part Fas up regulation on these cells and subsequent apoptotic cell death induced by interferon gamma and Fas ligand producing T cells in the BM microenvironment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Intratumoral T cell subset ratios and Fas ligand expression on brain tumor endothelium . ^^^ Fas ligand , a pro apoptotic cell surface protein , may play a key role in reduction of T cells in tumor tissue . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A reductase inhibitors decrease Fas ligand expression and cytotoxicity in activated human T lymphocytes . ^^^ One of the main mechanisms of cell death activation is the Fas Fas ligand ( FasL ) system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In particular , malignant plasma cells express very high levels of apoptogenic receptors , including both Fas ligand and tumor necrosis factor related apoptosis inducing ligand , which trigger apoptosis of immature erythroblasts by stimulating specific death receptors , namely Fas and the complex DR4 / DR5 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In order to show the usefulness of Genomic Object Net for representing and simulating biopathways , we show two HFPN representations of gene regulation mechanisms of Drosophila melanogaster ( fruit fly ) circadian rhythm and apoptosis induced by Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Molecular cloning , functional characterization , and enzyme linked immunosorbent assay of cynomolgus monkey Fas ligand . ^^^ Fas ligand ( FasL ) cDNAs were cloned and sequenced from cynomolgus , rhesus , and pig tailed monkeys . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : Myocardial biopsies from 17 patients at the time of LVAD implantation and after explantation , at the time of heart transplantation ( HTx ) , were examined by terminal deoxynucleotidyltransferase mediated dUTP nick end labeling ( TUNEL ) reaction and with antibodies against Fas ligand ( FasL ) , Fas , tumor necrosis factor ( TNF ) alpha receptor 1 ( TNF R 1 ) , TNF alpha receptor 2 ( TNF R 2 ) , TNF alpha , TNF alpha converting enzyme ( TACE ) , poly ( ADP ribose ) polymerase ( PARP ) , poly ( ADP ribose ) ( PAR ) , caspase 3 and FLICE inhibitory protein ( FLIP ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Gld mice , which have a Fas ligand mutation , have a slight yet insignificant decrease in bone mineral density , but a highly significant increase in osteoclast number . ^^^ Taken together , these data demonstrate that the Fas / Fas ligand system is important in the regulation of bone turnover and may represent a critical link between the immune system and bone remodeling in development and in various diseases . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Intraocular tumor rejection required CD 4 ( + ) T cells , but did not require the following : 1 ) CD 8 ( + ) T cells , 2 ) B cells , 3 ) TNF , 4 ) perforin , 5 ) Fas ligand , or 6 ) NK cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RCAS 1 ( receptor binding cancer antigen expressed on SiSo cells ) and Fas ligand ( FasL ) are present in neoplastic cells , induce apoptosis of NK / T cells , and play a role in immune evasion . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
FNBP 3 , binding to TNFSF 6 ( Fas ligand ) , Huntingtin and Formin proteins , might transduce extracellular signals to the Rho related signaling pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
HIV 1 and IL 1 beta regulate Fas ligand expression in human astrocytes through the NF kappa B pathway . ^^^ We hypothesized that in HAD , astrocytes activated with proinflammatory stimuli such as IL 1beta express Fas ligand ( FasL ) , a death protein . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Characterizing the cells in more detail , we could demonstrate for the first time that normal human LCs express CXCR 4 , CD 40 ligand ( CD40L ) , and Fas and Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This resulted in the increased constitutive expression of the FKHRL 1 targets Fas ligand and Bim , and promoted apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The second hypothesis , the ' epithelial hypothesis ' , suggests that epithelial injury in acute lung injury is associated with apoptotic death of alveolar epithelial cells triggered by soluble mediators such as soluble Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Anticancer drugs have been known to enhance both Fas receptor and Fas ligand expression on tumor cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Modification of tumor cells with Fas ( CD 95 ) antigen gene and Fas ligand ( CD95L ) gene transfection by electroporation for immunotherapy of cancer . ^^^ We describe here a method for the modification of tumor cells with the Fas / Apo 1 ( CD 95 ) antigen gene and Fas ligand ( FasL ) gene transfection through the use of electroporation , and suggest that the Fas FasL system is a good target for the induction of apoptosis mediated antitumor activity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunoprecipitation analysis indicated multimerization of Fas antigen without Fas ligand binding in ATX S 10 ( Na ) PDT treated NHK . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Lytic granules harbour many of the dangerous apoptosis inducing molecules of the immune system , including perforin , granzymes and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activation of Fas receptor by Fas ligand causes caspase 8 activation and apoptosis in cells and is an important mechanism by which normal tissue homeostasis and function are maintained . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We hypothesized that , in addition to Mac 1 binding , the killing process requires the activation of the Fas death receptor pathway , which can be blocked at the level of Fas Fas ligand interaction . ^^^ MM , but not VSMC , expressed Fas ligand ( FasL ) , and VSMC apoptosis was inhibited by secretion of sFas by VSMC upon Ad3sFas transduction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Epithelial ovarian cancer cells secrete functional Fas ligand . ^^^ The Fas / Fas ligand ( FasL ) system has been suggested to play an important role in the establishment of an immune privilege status of the tumor by inducing Fas mediated apoptosis in tumor specific lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Its ligands are LIGHT , Fas ligand , and TL1A , all TNF family members . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Both C 3 ( / ) and C 4 ( / ) mice had reduced levels of B cells and increased expression of apoptotis inducers ( Fas ligand , CD 69 ) and apoptotic cells in lymph nodes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas antigen is a cell surface receptor that induces apoptotic pathways when treated with Fas ligand or anti Fas antibody . ^^^ There is increasing evidence that apoptosis plays an important role in the immunopathogenesis of chronic viral hepatitis , in which the Fas antigen Fas ligand pathway is particularly involved . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The results here reported provide evidence that the nonfloating cells present severe shrinkage and highly express both FAS receptor and FAS ligand on their surface . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
IRF 2 has generally been described as an antagonist of IRF 1 mediated transcription of IFN and IFN inducible genes ; however , it has been recently identified as a transcriptional activator of some genes , such as those encoding histone H 4 , VCAM 1 ( vascular cell adhesion molecule 1 ) and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand induced murine pulmonary inflammation is reduced by a stable decoy receptor 3 analogue . ^^^ Fas ligand ( FasL ) induced lung inflammation has recently been suggested to play an important role in the pathogenesis of acute respiratory disease syndrome ( ARDS ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas antigen and Fas ligand in bronchoalveolar lavage from silicosis patients . ^^^ OBJECTIVE : To understand the role of apoptosis through Fas / Fas ligand ( FasL ) interaction in the pathogenesis of silicosis , we examined the expression of Fas antigen , FasL and apoptosis in bronchoalveolar lavage fluid lymphocytes obtained from patients with silicosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It is now clear that NK cells are capable of using death ligands like Fas ligand ( FasL ) or tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) to induce cytotoxicity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Comparison of wild type C57BL / 6 mice , gld mice , defective in the death ligand fasL , and bax / mice , defective in the pro apoptotic BAX protein , revealed a minor role for FAS ligand but a crucial role for BAX in both apoptosis and normal retinal development . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the present work we have investigated the role of the CD 95 system comprising the CD 95 receptor ( Fas , CD 95 , APO 1 ) and its ligand Fas ligand ( FasL ) in the dialogue between pancreatic tumor cells and tumor reactive / cytotoxic T cells . ^^^ CD 95 resistance and Fas ligand synthesis as mechanism of defense by immunocompetent cells in pancreatic tumors ] . ^^^ CD 95 resistance and Fas ligand synthesis as mechanism of defense by immunocompetent cells in pancreatic tumors ] . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Significance of allopeptide induced expression of Fas ligand ( FasL ) in parenchyma of allogenic heart transplants as the cause of donor specific tolerance induction ] . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Characterization of spontaneous transplant tolerance exemplified by orthotopic liver transplantation : significance of Fas ligand induced programmed cell death ] . ^^^ For the first time , this study provides strong evidence that hepatocytes express functional Fas ligand protein after orthotopic liver transplantation in specific allogeneic strain combinations . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas receptor was activated by incubating NRVM with recombinant Fas ligand ( rFasL , 50 ng / ml ) and enhancing antibody ( 1 microg / ml ) , or by incubation of murine ventricular myocytes with the Fas activating antibody Jo 2 ( 10 microg / ml ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand mediates immune privilege and not inflammation in human colon cancer , irrespective of TGF beta expression . ^^^ Many cancers express Fas ligand ( FasL / CD95L ) in vivo , and can kill lymphoid cells by Fas mediated apoptosis in vitro . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis can be induced by addition of fas ligand a process which can be blocked by antibodies against either fas or fas ligand . ^^^ Conditioned medium of dynamically cultivated VSMCs contains fas ligand as the only active apoptosis inducing activity . ^^^ So the exposure of VSMCs to shear stress leads to apoptosis by the establishment of an autocrine loop of fas and fas ligand a potential mechanism for the prevention of narrowing of vessel diameter by VSMC proliferation . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The human CC chemokine CCL 16 , a liver expressed chemokine , enhances the killing activity of mouse peritoneal macrophages by triggering their expression of tumor necrosis factor alpha ( TNF alpha ) and Fas ligand . ^^^ This ability to activate caspase 8 depends on their overexpression of TNF alpha and Fas ligand induced by CCL 16 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Combining Fas mutation with interleukin 2 deficiency prevents Colitis and Lupus : implicating interleukin 2 for auto reactive T cell expansion and Fas ligand for colon epithelial cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Co expression of Fas ( APO 1 , CD 95 ) / Fas ligand by BeWo and NJG choriocarcinoma cell lines . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
SNAP ( 0 . 5 mM ) lowered the expression of Fas and p 53 in luteinized granulosa cells , but Bcl 2 expression was increased , and Fas ligand or Bax remained unchanged . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The authors examined the hypothesis that nitric oxide ( NO ) , interleukin ( IL ) 6 , tumor necrosis factor ( TNF ) alpha , and cortisol correlate with Fas and Fas ligand ( FasL ) expression on peripheral blood mononuclear cells and that Fas and FasL , therefore , mediate their association with MODS severity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
HCV E 2 and HIV gp 120 acted collaboratively to trigger a specific set of downstream signaling events , including up regulation of the Fas ligand and dephosphorylation of the anti apoptotic molecule AKT . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The serum levels of apoptotic markers , soluble Fas ( sFas ) , soluble Fas ligand ( sFasL ) and Bcl 2 , were determined for both victims and controls . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In support of this hypothesis , cytokine gene engineered DCs expressed higher levels of MHC and costimulatory molecules , as well as Fas ligand and membrane bound tumor necrosis factor alpha , with the latter markers associated with elevated tumoricidal activity in vitro . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Egr family members regulate nonlymphoid expression of Fas ligand , TRAIL , and tumor necrosis factor during immune responses . ^^^ The Fas ligand ( FasL ) / Fas pathway is crucial for homeostasis of the immune system and peripheral tolerance . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In particular , Fas ligand ( FasL ) , expressed by activated T lymphocytes , induces cell mediated cytotoxicity and may also be responsible for apoptotic suicide . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Moreover , when neutrophils were exposed to Fas ligand , TNF alpha , or TRAIL , the anti apoptotic effects of granulocyte macrophage colony stimulating factor ( GM CSF ) , granulocyte colony stimulating factor ( G CSF ) , or IFN gamma were blocked , most likely by SHP 1 mediated inactivation of anti apoptotic signaling molecules . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunohistochemistry for caspase 3 and Fas ligand was performed . ^^^ Reverse transcriptase polymerase chain reaction for Fas ligand was also performed . ^^^ Fas ligand was induced in the liver infected with HSV , but not with UV HSV . ^^^ Not only viral replication but also non viral factor such as Fas ligand may facilitate rapid development of this disease . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OUTCOME MEASURES : Parameters reflecting tumor apoptotic status ( Bcl 2 ) , expression of death receptors ( Fas and Fas ligand [ FasL ] ) , intercellular adhesion molecule ( ICAM ) 1 , immunosuppressive microenvironment ( interleukin 10 ) , and antigen presentation machinery ( transporter associated with antigen presentation [ TAP ] 1 ) before and after imiquimod treatment were evaluated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas engagement by Fas Ligand can also trigger proliferation or differentiation , promote tumour progression and angiogenesis , and induce cytokine secretion and integrin expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Non functional Fas ligand increases the formation of cartilage early in the endochondral bone induction by rhBMP 2 . ^^^ It has previously been shown that mice with a defect in Fas ligand mediated apoptosis have an enhancement of ectopic bone formation . ^^^ We investigated the expression of bone related markers alkaline phosphatase , collagen , bone sialoprotein , osteocalcin , osteopontin , and bone morphogenetic proteins ( BMP ) 2 , 4 , and 7 ; and cytokines interleukin 1alpha ( IL 1 ) , IL 1beta , and tumor necrosis factor alpha ( TNF alpha ) in ectopic new bone induced by recombinant human ( rh ) BMP 2 in mice without functional Fas ligand ( gld mice ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TNF receptor ( TNFR ) , Fas , and Fas ligand ( FasL ) were used as indicators for activation of the death receptor mediated pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Engulfment of the apoptotic bodies , but not latex beads , stimulated Kupffer cell generation of death ligands , including Fas ligand , and tumor necrosis factor alpha ( TNF alpha ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although these CTLs partially killed HIV 1 infected PBMC through Fas ligand , CTLs still suppressed late steps of HIV 1 replication in the presence of neutralizing antibodies to Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The concentrations of the factors involved in apoptosis regulation transforming growth factor beta 1 ( TGF beta 1 ) , soluble Fas ( sFas ) , soluble Fas ligand ( sFasL ) and protein bcl 2 were measured in serum before ( examination 1 ) and after ( examination 2 ) four weeks of antibiotic treatment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Using viral vectors , we have genetically engineered the APCs to process and present the most important domain of the AChR molecule , and to express a `` warhead ' ' of Fas ligand ( FasL ) to eliminate the activated AChR specific T cells with which they interact . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Transforming growth factor beta 1 induces apoptosis through Fas ligand independent activation of the Fas death pathway in human gastric SNU 620 carcinoma cells . ^^^ Herein , we report that apoptosis of human gastric SNU 620 carcinoma cells induced by TGF beta 1 is caused by the Fas death pathway in a Fas ligand independent manner , and that the Fas death pathway activated by TGF beta 1 is linked to the mitochondrial apoptotic pathway via Bid mediation . ^^^ Interestingly , expression of dominant negative FADD and treatment with caspase 8 inhibitor efficiently prevented TGF beta 1 induced apoptosis , whereas the treatment with an activating CH 11 or a neutralizing ZB 4 anti Fas antibody , recombinant Fas ligand , or Fas Fc chimera did not affect activation of Fas and the subsequent induction of apoptosis by TGF beta 1 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Primary leukocyte suspensions were prepared from murine thymus ( TH ) , spleen ( SP ) , bone marrow ( BM ) and Peyer ' s patches ( PP ) and then cultured with DON in the absence or presence of LPS , prostaglandin E 2 ( PGE 2 ) , anti immunoglobulin ( as antigen mimic ) , dexamethasone , Fas ligand , or TNF alpha . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand and TNF alpha were also detected among pancreas infiltrating cells , whereas Fas was rarely expressed in the pancreatic acinar cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand mediated apoptosis in degenerative disorders of the brain . ^^^ Recent reports have suggested that the key apoptosis regulator Fas ligand ( FasL ) may participate in both neuronal and immune cell apoptosis in Alzheimer ' s disease . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Induction of FAS ligand expression in a human hepatoblastoma cell line by HCV core protein . ^^^ Tumour cells and virus infected cells expressing Fas ligand ( FasL ) can evade immune surveillance by inducing apoptosis in T cells expressing Fas . ^^^ In order to characterise a possible role of hepatitis C virus ( HCV ) core protein in similar mechanisms during HCV infection , we investigated Fas ligand expression and activity in a human hepatoblastoma cell line ( HepG 2 ) constitutively expressing this protein . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
PURPOSE : Because increased enterocyte apoptosis has been associated with the pathogenesis of several chronic inflammatory diseases , the aim of our study was to investigate epithelial cell death in Crohn ' s disease and the possible role of the Fas Fas ligand system , E cadherin , and matrix metalloproteinase 1 in modulating enterocyte apoptosis in this condition . ^^^ Biopsy specimens were processed for traditional histology and for the immunohistochemical evaluation of Fas , Fas ligand , E cadherin , Ki 67 antigen , and matrix metalloproteinase 1 expression . ^^^ In Crohn ' s disease , both enterocyte Fas and lamina propria mononuclear cell Fas ligand expression did not differ from controls . ^^^ This increase is not mediated by a Fas Fas ligand mechanism or by an abnormal E cadherin distribution . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis inducing `` death ligands ' ' Fas ligand and TNF related apoptosis inducing ligand ( TRAIL ) are genes with substantial cytotoxic activity in susceptible tumor cells . ^^^ Here , we compared the effectiveness of Ad vector mediated delivery of Fas ligand green fluorescent protein ( FasL GFP ) fusion protein , human TRAIL , and both genes simultaneously . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It is well known that Fas ligand and anti Fas antibodies can induce apoptosis , although some cancer cells are resistant to their stimuli . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We show that both KIR+ and KIR antigen specific CTLs express Fas and Fas ligand and were susceptible to activation induced cell death ( AICD ) triggered by coated anti CD 3 monoclonal antibodies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , Fas ligand ( Fas L ) , another member of TNF super family ( TNF SF ) , is primarily recognized for its apoptotic actions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
T cell apoptosis and suppression of T cell receptor / CD3 zeta by Fas ligand containing membrane vesicles shed from ovarian tumors . ^^^ Because these membrane fragments ( MFs ) express biologically active components , such as Fas ligand ( FasL ) , the objective of this study was to define the link between the presence of shed membrane vesicles , apoptosis , and suppression of T cell receptor / CD3 zeta expression in T lymphocytes of patients with ovarian cancer . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptotic response to 5 fluorouracil treatment is mediated by reduced polyamines , non autocrine Fas ligand and induced tumor necrosis factor receptor 2 . 5 fluorouracil ( 5 FU ) is the major chemotherapeutic agent for treatment of colorectal carcinoma , but the molecular mechanisms of response and resistance are not understood completely . ^^^ In the sensitive cells which have wild type p 53 , the p 53 gene and its downstream genes including p21 / WAF1 , mdm 2 , Fas , mic 1 , EphA 2 , and ferredoxin reductase as well as genes in the tumor necrosis factor ( TNF ) pathway including TNF receptor 2 ( TNFR 2 ) were induced , but not Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas ( CD 95 , APO 1 ) receptor is a transmembrane cell surface receptor that mediates apoptosis in many cell types when bound by the Fas ligand or cross linked by agonistic anti Fas antibodies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Snap frozen samples were examined for local gene expression of TGF beta , TNF alpha , GM CSF , VEGF , PDGF and Fas Ligand ( FasL ) by real time quantitative rt PCR normalized to the housekeeping gene GAPDH and compared to unstented coronary arteries . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL ) is a type 2 transmembrane protein that plays a critical role in immune homeostasis by binding to its receptor Fas ( CD 95 ) and inducing apoptosis . ^^^ The multiple roles of Fas ligand in the pathogenesis of infectious diseases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The yields were observed and Fas Ligand ( Fas L ) was tested by immunohistochemical method . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We considered spontaneous lymphomonocyte apoptosis ( evaluated by ELISA ) , interleukin ( IL ) 2 production ( evaluated by ELISA ) , Fas expression on T cells ( evaluated by flow cytometry ) and Fas ligand mRNA ( evaluated by reverse transcriptase polymerase chain reaction ) , as well as Fas functionality . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CAPE activated Fas by a Fas ligand ( Fas L ) independent mechanism , induced p 53 regulated Bax protein , and activated caspases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Regulation of Fas ( APO 1 , CD 95 ) and Fas ligand expression in leukocytes during systemic inflammation in humans . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand transcript levels in CD 4 T cells were significantly elevated in SCT recipients without GVHD compared to patients with GVHD ( 20 CD3epsilon units / T cell ( 0 78 ) vs 0 CD3epsilon units / T cell ( 0 0 ) , P=0 . 01 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Therefore , we investigated whether or not Fas and Fas ligand ( FasL ) influenced the production of erythropoietin ( EPO ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cutting edge : SDS stable Fas microaggregates : an early event of Fas activation occurring with agonistic anti Fas antibody but not with Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fibronectin associated Fas ligand rapidly induces opposing and time dependent effects on the activation and apoptosis of T cells . ^^^ Recently , it has been shown that Fas ligand ( FasL ) interacts with the extracellular matrix ( ECM ) protein fibronectin ( FN ) , and that the bound FasL retains its cytotoxic efficacy . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas , Fas ligand , FLIP , TNF alpha , inducible NO synthase , TGF beta , and IFN gamma were highly expressed by infiltrating cells when G EAT progressed to fibrosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this review , we chronicle the discovery , biochemical characterization , and assignment of Fas ( CD 95 ) as receptor and Fas Ligand ( FasL , CD95L ) as ligand . ^^^ Fas ligand : receptor or ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble forms of Fas and Fas ligand concentrations in the seminal plasma of infertile men with varicocele . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Examination of soluble Fas ( sFas ) and soluble Fas ligand ( sFasL ) in patients with burns . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR induced Fas ligand expression . ^^^ We show in the present work that phosphatidylinositol 3 kinase ( PI3K ) inhibitors wortmannin and LY 294002 prevent TCR / CD3 induced functional Fas ligand ( FasL ) expression , but not perforin dependent cytotoxicity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Protection against murine leukemia virus induced spongiform myeloencephalopathy in mice overexpressing Bcl 2 but not in mice deficient for interleukin 6 , inducible nitric oxide synthetase , ICE , Fas , Fas ligand , or TNF R 1 genes . ^^^ We show here that interleukin 6 ( IL 6 ) , inducible nitric oxide synthetase ( iNOS ) , ICE , Fas , Fas ligand ( FasL ) , and TNF R 1 KO mice still develop signs of disease . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Further analysis demonstrated that inhibition of Fas ligand , tumor necrosis factor alpha , or TRAIL signaling with blocking reagents did not affect fenretinide induced apoptosis , raising the possibility that fenretinide activates caspase 8 in a death receptor independent manner . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The cell surface Fas antigen transducts an apoptotic signal by its crosslinking with Fas ligand or anti Fas antibody in a variety of human cultured cells . ^^^ Both Fas ligand and Fas associated phosphatase 1 ( FAP 1 ) were expressed only in COLO320DM . ^^^ These results indicated that ( 1 ) Fas antigen was variably expressed , regardless of the p 53 gene status and ( 2 ) the susceptibility to anti Fas antibody mediated apoptosis did not correlate to Fas , Fas ligand or FAP 1 expression levels . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We and others have recently shown that human NK cells express the Fas ligand ( FasL ) constitutively and that they can trigger the lysis of Fas positive ( Fas+ ) target cells ( TC ) by apoptosis . ^^^ They also partially lose their ability to fragment DNA . ( 2 ) NK cells exposed to Fas+ TC completely recover the Fas lytic pathway and the ability to fragment DNA via the Fas / Fas ligand when incubated in medium supplemented with IL 2 for 18 h . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
FR 901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells . ^^^ Induction of apoptosis was preceded by increased expression of Fas ligand ( FasL ) mRNA , resulting in expression of membrane bound FasL , which was followed by sequential activation of caspase 8 and 3 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RESULTS : Although there were no significant differences in IVM outcomes and follicular gene expression between the two experimental groups , cryopreservation appears to induce the expression of heat shock proteins , DNA damage inducible protein 45 and death related apoptosis genes ( i . e . , Fas and Fas ligand ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas antigen and soluble Fas ligand in early neonatal life . ^^^ AIM STUDY DESIGN : Soluble Fas ( sFas ) and soluble Fas ligand ( sFasL ) concentrations were measured in maternal serum ( MS ) , umbilical cord ( UC ) and neonatal serum in the first ( 1N ) and fifth ( 5N ) days after birth in order to evaluate the alterations of these molecules during the early neonatal period . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These two antibodies caused reductions , to varying levels , of the amounts of NK cell derived granzyme B ( GrB ) and pro inflammatory cytokines , but only the anti CD 95 antibody affected the production of soluble Fas ligand ( sFasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Unexpectedly , they also display stable cross resistance to tunicamycin , thapsigargin , dithiothreitol , and cycloheximide but not doxorubicin , etoposide , or Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Enhancement of germ cell apoptosis induced by ethanol in transgenic mice overexpressing Fas Ligand . ^^^ In the present study , we use a model of transgenic mice ubiquitously overexpressing human FasL to investigate whether Fas ligand plays a role in ethanol induced testicular germ cell apoptosis . ^^^ After ethanol injection , WT mice displayed up regulation of Fas ligand in the testes , which was shown by FITC conjugated flow cytometry and western blotting . ^^^ In summary , we provide the direct evidences that Fas ligand mediates the apoptosis of testicular germ cells induced by acute ethanol using FasL transgenic mice . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cytochrome c released from mitochondria was found in a subset of progenitor cell progeny , while Fas ligand and tumor necrosis factor 1 receptor associated domain as well as the mitochondria related , caspase independent apoptosis inducing factor were not detected . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand immunoexpression in pancreatic islets of NOD mice during spontaneous and cyclophosphamide accelerated diabetes . ^^^ During insulin dependent diabetes mellitus , beta cell destruction may involve activation of the Fas Fas ligand ( Fas FasL ) system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Various proteins encoded in the adenovirus ( Ad ) E 3 transcription unit protect cells from killing mediated by cytotoxic T cells and death inducing cytokines such as tumor necrosis factor ( TNF ) , Fas ligand , and TNF related apoptosis inducing ligand ( TRAIL ) . ^^^ The receptor internalization and degradation ( RID ) complex ( formerly E 3 10 . 4 K / 14 . 5 K ) stimulates the clearance from the cell surface and subsequent degradation of the receptors for Fas ligand and TRAIL , thereby preventing the action of these important immune mediators . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Quantitative ELISA was performed to detect plasma levels of TNF alpha and soluble Fas ligand . ^^^ Evaluation of plasma soluble Fas ligand revealed significantly decreased levels in patients compared with controls . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Sustained suppression of Fas ligand expression in cisplatin resistant human ovarian surface epithelial cancer cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Okadaic acid stimulates expression of Fas receptor and Fas ligand by activation of nuclear factor kappa B in human oral squamous carcinoma cells . ^^^ In the present study , we used western blot and RT PCR analysis to examine the expression of proteins and mRNAs of Fas receptor and Fas ligand in human oral squamous carcinoma SCC 25 cells treated with okadaic acid . ^^^ Treatment with okadaic acid enhanced the expression of proteins and mRNAs of both Fas receptor and Fas ligand in SCC 25 cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND / AIMS : The perforin / granzyme and Fas / Fas ligand pathways are two known major pathways of cytotoxic T lymphocyte mediated apoptosis . ^^^ RT PCR , immunoblotting and immunohistochemistry were used to study the samples for the expression of apoptotic cells , perforin , granzyme B , Fas , Fas ligand and caspase 3 . ^^^ Perforin / granzyme B and caspase 3 were expressed consistently , however Fas ligand was not . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Adenovirus expressing p27KIP1 induces apoptosis against cholangiocarcinoma cells by triggering Fas ligand on the cell surface . ^^^ In this report , we examined whether p27kip1 induced apoptosis is closely related to the Fas / Fas ligand ( FasL ) system . ^^^ RESULTS : After infection of Adp 27 , flow cytometric analysis showed that Fas ligand was expressed on the cell surface of cholangiocarcinoma cell lines ( TFK 1 ) . ^^^ In spite of detecting the cell surface expression of Fas ligand , overexpression of p27kip1 increased no amount of Fas ligand in mRNA by quantitative RT PCR and protein level by Western blot . ^^^ In addition , the immunocytochemical analysis showed that Fas ligand was adequately stored within the cytosol of TFK 1 cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Decoy receptor 3 ( DcR 3 ) , a newly identified soluble protein belonging to the tumor necrosis factor receptor ( TNFR ) superfamily , is a receptor for Fas ligand ( FasL ) , LIGHT and TL1A . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Because the unphosphorylated form of FKHRL 1 binds the Fas ligand promoter , thereby inducing apoptosis , we further examined the effect of the phosphorylation status of FKHRL 1 on the activity of the Fas ligand promoter in the presence of cisplatin . ^^^ Transfection with the kinase inactive mutant of Akt or TM of FKHRL 1 induced the activity of the Fas ligand promoter in Caov 3 cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The leukocytes adhered to the vasculature through CD 18 and remodeled it through Fas ligand ( FasL ) mediated endothelial cell apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Synergistic protective effect of testicular cells expressing Fas ligand and cyclosporine A on the survival of islet allografts ] . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Study on blocking the tumor immune escape by Fas ligand pathway ] . ^^^ The expression of Fas ligand ( FasL ) on the membrane of many kinds of leukemia or solid tumor cells played an important role in the immune escape of tumor cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recently much attention has been drawn to different apoptotic pathways induced by naturally occurring death receptor ligands ( such as tumor necrosis factor , Fas ligand , and tumor necrosis factor related apoptosis inducing ligand ) or induced by drugs that affect the downstream pathway from the epidermal growth factor receptor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Among T cells , activation induced expression of the tumor necrosis factor ( TNF ) related apoptosis inducing ligand ( TRAIL ) is observed exclusively in Th 2 clones and primary T helper cells differentiated under Th 2 conditions , while the expression of CD95L ( Fas ligand ) occurs mainly in Th 1 cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Severe malarial anemia associated with increased soluble Fas ligand ( sFasL ) concentrations in Gabonese children . ^^^ To investigate if severe malarial anemia is associated with specific cytokine overproduction , we evaluated serum levels of soluble Fas ligand ( sFasL ) , tumor necrosis factor ( TNF alpha ) and interleukin 10 ( IL 10 ) from three groups of young children with Plasmodium falciparum infection ( asymptomatic cases , uncomplicated malaria cases and severe malarial anemia cases ) , in a hyperendemic area of Gabon . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Myocardial injury was determined by triphenyltetrazolium chloride ( TTC ) staining , terminal deoxynucleotidyl transferase mediated dUTP nick end labeling ( TUNEL ) , bax , bcl 2 , poly ( ADP ) ribose polymerase ( PARP ) cleavage , caspase 3 , 8 , and 9 cleavage and activity , Fas ligand ( FasL ) , and Fas activated death domain ( FADD ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
O ( 6 ) MeG triggered apoptosis in proliferating lymphocytes was preceded by a wave of DSBs , which coincided with p 53 and Fas receptor upregulation , while Fas ligand , Bax and Bcl 2 expression was not altered . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ethanol binge increased caspase 3 and caspase 8 activity , the expression of Fas ligand , and terminal deoxynucleotidyl transferase mediated deoxyuridine triphosphate nick end labeling in fa / fa rats . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Experimental evidence implicates Fas ligand mediated keratinocyte apoptosis as an underlying mechanism of toxic epidermal necrolysis syndrome ( TEN ) . ^^^ In vitro studies indicate a potential role for immunoglobulin ( Ig ) therapy in blocking Fas ligand signaling , thus reducing the severity of TEN . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Model systems with target gene manipulations involving Fas ligand , Fas , perforin , interleukin 2 , and cytotoxic T lymphocyte associated antigen 4 exist and in all cases appear to disrupt critical cytotoxic regulatory cell function . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Two days after reperfusion , expression of Fas ligand increased in the CA 1 region and the orthovanadate injection inhibited this increased expression . ^^^ These results suggested that the inactivation of Akt results in the activation of FKHR and , in turn , relates to the expression of Fas ligand in the hippocampal CA 1 region after transient forebrain ischemia . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cytotoxic cytokines such as tumor necrosis factor ( TNF ) alpha or Fas ligand ( FasL ) bind to their receptors to activate caspase 8 , while damaging agents can cause mitochondrial release of cytochrome c , which can initiate activation of caspase 9 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Effector cell derived lymphotoxin alpha and Fas ligand , but not perforin , promote Tc 1 and Tc 2 effector cell mediated tumor therapy in established pulmonary metastases . ^^^ Although both effector cell subpopulations display Fas ligand ( FasL ) and tumor necrosis factor ( TNF ) , tumor lysis is predominantly perforin dependent in vitro . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Reactive oxygen intermediates have additionally been proposed to be of general importance for the expression of FAS and soluble FAS ligand ( sFASL ) and the subsequent induction of apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Zeta associated protein of 70 kDa ( ZAP 70 ) , but not Syk , tyrosine kinase can mediate apoptosis of T cells through the Fas / Fas ligand , caspase 8 and caspase 3 pathways . ^^^ Activated Z / ZAP transfectants increased Fas and Fas ligand ( FasL ) expression 3 and 40 fold , respectively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
IFN gamma promotes Fas ligand and perforin mediated liver cell destruction by cytotoxic CD 8 T cells . ^^^ IFN gamma ( null ) ) , functional Fas ligand ( P14 . gld ) , or perforin ( P14 . ^^^ Liver injury was mediated by the Fas / Fas ligand ( FasL ) pathway and by perforin , because P14 . gld and P14 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Because heterogeneity among endothelial cells from different tissues , has been demonstrated , the purpose of this study was to determine , if Fas ligation and / or activation by human Fas ligand induces apoptosis and caspase activities , in cultured human coronary artery endothelial cells , and the differences between TNF a and FAS induced apoptosis in these cells . ^^^ RESULTS : Cultured human coronary artery endothelial cells ( HCAEC ) were exposed to the monoclonal Fas activating antibody CH 11 , to purified recombinant human Fas ligand , to the Fas neutralizing antibody ZB 4 , or to purified recombinant human TNF alpha . ^^^ Apoptosis was induced in HCAEC by purified Fas ligand or by the monoclonal activating antibody CH 11 at concentrations of 25 or 200 ng / ml , but not by nonspecific isotype matched immunoglobulins . ^^^ CONCLUSIONS : Cultured human coronary artery endothelial cells express functional Fas capable of inducing apoptosis in response to either purified Fas ligand or receptor activating monoclonal antibodies , at levels equal to those inducible by purified TNF alpha . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Perforin ( / ) mice showed an elevation of transaminase while B 6 gld / gld mice ( Fas ligand ) showed a decreased elevation of transaminase . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NF kappaB activation and Fas ligand overexpression in blood and plaques of patients with carotid atherosclerosis : potential implication in plaque instability . ^^^ Nuclear factor kappaB ( NF kappaB ) is involved in the transcriptional regulation of the proapoptotic protein Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Caspase 8 and 3 activity , and concentrations of TNF alpha , Fas , Fas ligand , cytochrome c , and adenosine triphosphate ( ATP ) were measured in the neocortex by enzymatic assay and Western blot analysis . ^^^ Fas ligand and TNF alpha were not observed in any group . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Levels of granzyme B , perforin and Fas ligand antigens and mRNAs in patients following allogeneic hematopoietic stem cell transplantation ] . ^^^ In order to monitor the immunological status of patients after allogeneic hematopoietic stem cell transplantation ( HSCT ) , granzyme B ( GrB ) , perforin ( PRF ) and Fas ligand ( L ) antigens and mRNAs were measured by flow cytometry and real time RT PCR , respectively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVES : To determine the roles of proliferation , apoptosis , Fas ( CD 95 ) , Fas ligand ( FasL ) and telomerase in changes of human epidermis during ageing . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
At week 14 , liver injury was significantly greater in the resolved outcome and associated with higher mean Fas ligand ( FasL ) and perforin messenger RNAs ( mRNAs ) in liver compared to the chronic outcome . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand protein and mRNA in normal and atretic mouse ovarian follicles . ^^^ In the present study , expression of Fas and Fas ligand , the proximal members of the death receptor pathway , was evaluated in mouse ovarian follicles using immunofluorescence and in situ hybridization . ^^^ Expression of both Fas and Fas ligand mRNA and protein was observed in granulosa cells of normal and atretic follicles . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas and Fas ligand protein and mRNA in mouse oocytes and embryos . ^^^ In the present study , expression of Fas and Fas ligand the proximal members of the death receptor pathway , was evaluated in mouse preimplantation embryos by immunofluorescence and in situ hybridization techniques . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We demonstrate that this phenomenon occurs via a PDK1 / PKB / GSK3 / NF ATc signaling cascade that controls the production of the proapoptotic hormone Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RESULTS : CD4+ T cells from MGS significantly expressed mRNA of interferon ( IFN ) gamma , interleukin ( IL ) 2 , granulocyte macrophage colony stimulating factor ( GM CSF ) , transforming growth factor ( TGF ) beta , tumor necrosis factor ( TNF ) alpha , IL 4 , CD 40 ligand ( CD40L ) , Fas ligand ( FasL ) and IL 2 receptor ( IL 2R ) during dry period , and mRNA of IFN gamma , IL 2 and TGF beta during lactation period . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interleukin 12 enhances the sensitivity of human osteosarcoma cells to 4 hydroperoxycyclophosphamide by a mechanism involving the Fas / Fas ligand pathway . ^^^ The purpose of these studies was to determine whether alkylating agents affect the expression of Fas ligand ( FasL ) and whether interleukin 12 enhances the sensitivity of human OS cells to alkylating agents . 4 Hydroperoxycyclophosphamide ( 4 HC ) , the preactivated CY compound , and 4 hydroperoxydidechlorocloclophosphamide ( 4 HDC ) , its nonalkylating analogue , human OS LM 6 cells , and a clone of cells derived by transfection with the interleukin 12 gene ( LM 6 # 6 ) were used for these studies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression and role of Fas ligand in intestinal inflammation . ^^^ Fas ligand ( FasL ) is involved in the pathogenesis of inflammatory diseases and immune privilege . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Complete loss of Fas ligand gene causes massive lymphoproliferation and early death , indicating a residual activity of gld allele . ^^^ To investigate the in vivo function of Fas ligand ( FasL ) , we produced a mouse strain with a FasL gene flanked by loxP sequences . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand is not a main mechanism used by tumors to counteract antitumor immunity . ^^^ The role of Fas ligand ( FasL ) in tumor immune privilege is controversial . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Similarly , Fah ( / ) animals with liver injury were also resistant to apoptosis induced by the Fas ligand Jo 2 and to necrosis like cell death induced by acetaminophen ( APAP ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A soluble decoy receptor , DcR 3 , belongs to the tumor necrosis factor receptor ( TNFR ) family , and this receptor is known to bind to three TNF family ligands , namely Fas ligand ( FasL ) , LIGHT , and TL1A . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , Fas ligand and TRAIL mediated apoptosis was potentiated in death receptor resistant ( U 266 ) and sensitive ( RPMI 8226 / S ) cell lines . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To elucidate the role of apoptosis in cutaneous sclerosis , we examined the induction of apoptosis and expression of Fas , Fas ligand , as well as caspase 3 in a murine model of bleomycin induced scleroderma . ^^^ Fas ligand expression was increased in mononuclear cells as well as fibroblasts in the sclerotic skin . ^^^ Results of reverse transcription polymerase chain reaction analysis revealed that expression of Fas ligand mRNA was upregulated and reached a maximum at 3 wk , whereas Fas mRNA was continuously detected . mRNA expression as well as activity of caspase 3 was also enhanced at 3 wk . ^^^ Administration of neutralizing anti Fas ligand antibody together with local bleomycin treatment reduced the development of dermal sclerosis , associated with the reduction of TUNEL positive mononuclear cells and also with the blockade of apoptosis . ^^^ Caspase 3 activity in the lesional skin was also significantly reduced after anti Fas ligand treatment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Human Fas ligand expression on porcine endothelial cells does not protect against xenogeneic natural killer cytotoxicity . ^^^ As these leukocytes express the death receptor Fas either constitutively ( PMN ) or upon activation ( NK , CTL ) , we explored in vitro whether the transgenic expression of Fas ligand ( FasL ) on porcine endothelial cells ( EC ) is a valuable strategy to protect porcine xenografts . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas and Fas ligand on spleen T cells of experimental animals after unmodified or leukoreduced allogeneic blood transfusions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Enhanced neutrophil apoptosis in neutropenic patients with hepatosplenic schistosomiasis : evidence of serum Fas ligand . ^^^ Neutrophils from healthy subjects were also incubated with either 10 % heterologous normal or neutropenic serum , with and without anti Fas ligand antibody . ^^^ These findings suggest that the enhanced neutrophil apoptosis that occurs in neutropenic HS patients is triggered by a serum factor , which is mostly a Fas ligand . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The regulatory role of FK 506 on donor T cells was tested by analysis of donor T cell expansions in the spleen and donor anti host T cell proliferative and cytotoxic responses . mRNA expression of type 1 T helper ( Th 1 ) , Fas ligand ( L ) , and granzyme B were also evaluated in target organs of GvHD . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Kinetics and specificity of fas ligand induction in toxic epidermal necrolysis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here , we report that Fas engagement with Fas ligand induced activation of Akt and upregulation of endothelial nitric oxide synthase expression without induction of apoptosis . ^^^ In the presence of the phosphatidylinositol 3 kinase inhibitor wortmannin , Fas ligand , however , induced apoptosis instead of upregulation of endothelial nitric oxide synthase expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Abnormal structural luteolysis in ovaries of the senescence accelerated mouse ( SAM ) : expression of Fas ligand / Fas mediated apoptosis signaling molecules in luteal cells . ^^^ In the present study , to show the abnormality of Fas ligand ( FasL ) / Fas mediated apoptosis signal transducing factors in the aaLBs of the SAMP ovaries , we assessed the changes in the expression of FasL , Fas , caspase 8 and caspase 3 mRNAs by reverse transcription polymerase chain reaction , and in the expression and localization of FasL , Fas and activated caspase 3 proteins by Western blotting and immunohistochemistry , respectively , during the estrus cycle / luteolysis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , ectopic expression of activated STAT 3 results in partial rescue from apoptosis of cells treated with FAS ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
PURPOSE : To determine the prognostic value of Fas receptor and Fas ligand ( FasL ) as apoptosis related biomarkers in the context of chemoresponsiveness in breast cancer ( BC ) patients submitted to anthracycline based adjuvant therapy . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas ( sFas ) and soluble Fas ligand ( sFasL ) are associated with cellular dysfunction and death and are elevated in CSF from patients with HIV dementia ( HIV D ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of cyclooxygenase 2 , Fas and Fas ligand in pulmonary adenocarcinoma and atypical adenomatous hyperplasia . ^^^ Cyclooxygenase 2 ( COX 2 ) , Fas and Fas ligand ( FasL ) are believed to be involved in the pathogenesis and progression of cancer . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression is a risk factor for liver metastasis in colorectal cancer with venous invasion . ^^^ The expression of Fas ligand ( Fas L ) was investigated in sixty seven patients with colorectal cancer for possible correlation with liver metastasis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Listeria monocytogenes virulence proteins induce surface expression of Fas ligand on T lymphocytes . ^^^ In vitro culture of murine splenocytes with L . monocytogenes resulted in a specific and dose dependent upregulation of Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ovaries were paraffin embedded for hematoxylin and eosin histology , TUNEL assay , and immunohistochemistry for Fas , Fas ligand ( FasL ) , and proliferating cell nuclear antigen ( PCNA ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Their tumor cells were positive for CD 3 epsilon , TIA 1 , granenzyme B , CD 95 , CD95L ( Fas ligand ) , Bax , and CPP 32 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cells from the CD4+ murine T hybridoma line IP 12 7 enter the apoptotic suicide program via the Fas ligand ( FasL ) / Fas mediated pathway upon TCR stimulation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Moderate Bcl 2 expression was sufficient to render one glioma cell line ( D 270 ) resistant to apoptosis induced by Fas ligand or TRAIL , consistent with these cells being type 2 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The current study addresses the role of c FLIP L in regulation of cell death in PC 12 cells induced by nerve growth factor ( NGF ) withdrawal and Fas antibody , which acts as a Fas ligand and activates the Fas receptor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cytolytic effector mechanisms and gene expression in autologous graft versus host disease : distinct roles of perforin and Fas ligand . ^^^ To determine the temporal development and relative importance of these mechanisms in autoGVHD , perforin / granzyme , Fas ligand ( FasL ) , interferon gamma ( IFN gamma ) , tumor necrosis factor ( TNF ) alpha , and interleukin 18 gene expression in peripheral blood mononuclear cells was examined in 36 patients treated with CsA after SCT . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It has been known that Fas ligand ( FasL ) and perforin / granzyme B based mechanisms account for all T cell mediated cytotoxicity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble form of Fas and Fas ligand in serum and bronchoalveolar lavage fluid of individuals infected with human T lymphotropic virus type 1 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
ECH , an epoxycyclohexenone derivative that specifically inhibits Fas ligand dependent apoptosis in CTL mediated cytotoxicity . ^^^ CTL eliminate cells infected with intracellular pathogens and tumor cells by two distinct mechanisms mediated by Fas ligand ( FasL ) and lytic granules that contain perforin and granzymes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Survivin enhances Fas ligand expression via up regulation of specificity protein 1 mediated gene transcription in colon cancer cells . ^^^ In addition , cancer cells express Fas ligand ( FasL ) on their surfaces as a counterattack against immune cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In primary human macrophages and macrophages from Fas or Fas ligand ( FasL ) deficient mice , interruption of Fas FasL signaling suppressed nuclear factor kappa B activation and cytokine expression induced by IL 1 beta and lipopolysaccharide . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Production of the soluble human Fas ligand by Dictyostelium discoideum cultivated on a synthetic medium . ^^^ Human Fas ligand ( hFasL ) is of considerable interest since it is a type 2 transmembrane glycoprotein that induces programmed cell death , or apoptosis . ^^^ In this study Dictyostelium discoideum was used to produce a soluble form of the human Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We observed increased levels of several Fas mediated apoptosis effectors ( Fas , Fas ligand , FADD , FLICE ) , both in cell cultures at advanced passages and in skin cells of aged donors ( above 45 years ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand gene transfer to the embryonic heart induces programmed cell death and outflow tract defects . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This study reports on the relationship between quantitative ( 99m ) Tc HYNIC radiolabelled annexin 5 tumour uptake measurements , Fas ligand ( FasL ) expression , matrix metalloproteinase 9 ( MMP 9 ) expression , microvessel density ( MVD ) and the number of tumour infiltrating lymphocytes in squamous cell carcinoma of the head and neck ( SCCHN ) patients . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It is possible to induce apoptosis of the allo antigen specific T cells of grafts activated by allo antigen by exogenous Fas ligand expressed on recipient cells and this might provide a new approach for preventing GVHD and IL 2 may be more suitable for clinical application . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NK 92 IL15 cells were more strongly cytotox against a broad range of target tumor cells than the parent NK 92 cells , and this increased cytotoxicity was correlated to the increased expression of cytotoxic effector molecules , such as perforin , Fas ligand and IFNgamma , and up or down regulated expression of activating or inhibitory NK cell receptors ( NKG2D or NKG2A / CD94 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Placental Fas and Fas ligand expression in normal early , term and molar pregnancy . ^^^ To clarify the Fas and Fas ligand status of normal and molar trophoblast , the expression of Fas and FasL by placental trophoblast populations in partial and complete hydatidiform moles was compared with that in normal first trimester and term pregnancies using an avidin biotin peroxidase technique on frozen and formalin fixed paraffin embedded placental tissues with both monoclonal and polyclonal antibodies . ^^^ The immunoreactivity for Fas and Fas ligand was comparable with both monoclonal and polyclonal antibodies on frozen as well as paraffin embedded sections . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand mediated apoptosis in degenerative disorders of the brain . ^^^ Recent reports have suggested that the key apoptosis regulator Fas ligand ( FasL ) may participate in both neuronal and immune cell apoptosis in Alzheimer ' s disease . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Several mutations have been found in the genes encoding proteins that are involved in the apoptotic cascade , which starts with the binding of the Fas ligand to the transmembranous Fas protein and which is followed by intracellular processes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand gene therapy for vascular intimal hyperplasia . ^^^ Fas , a member of the tumor necrosis factor receptor super family , is expressed in all cell types examined , while physiologic expression of Fas ligand ( FasL ) is found predominantly in activated T lymphocytes , vascular endothelial cells , and `` immune privileged ' ' tissues . ^^^ However , Fas ligand based gene therapy appears to offer several advantages . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Results from Western blot analysis demonstrated an increased expression of the FAS ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand down regulates cytokine induced Fas receptor expression on insulinoma ( NIT 1 ) , but not islet cells , from autoimmune nonobese diabetic mice . ^^^ To determine whether beta cells can modulate their sensitivity to apoptosis at the level of Fas , we investigated the effect of Fas ligand ( FasL ) on surface expression of Fas in NIT 1 insulinoma cells from nonobese diabetic ( NOD ) mice prone to autoimmune diabetes and islet cells from NOD and nonautoimmune BALB / c mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although 5 FU up regulated FasR expression on melanoma cells , sensitization was not blocked by anti Fas Ab , and the G 209 specific CTL was Fas ligand ( FasL ) negative . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , IL 18 failed to suppress the growth of Dunn osteosarcoma cells transplanted into BALB / c nude mice devoid of T lymphocytes or C3H gld / gld mice deficient in functional Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Kupffer cell derived Fas ligand plays a role in liver injury and hepatocyte death . ^^^ The aim of this study was to determine the role of Fas ligand ( FasL ) in hepatocyte injury . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
PURPOSE : The expression of Fas ligand ( FasL ) in the cornea is essential for corneal allograft acceptance in mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
PEDF proteins showed dose dependent induced growth retardation and apoptotic cell death in nontransfected G 361 cells , which were completely prevented by treatment with antibodies against the Fas ligand . ^^^ Our present study highlights two beneficial effects of PEDF treatment on melanoma growth and expansion ; one is the suppression of tumor angiogenesis , and the other is induction of Fas ligand dependent apoptosis in tumor cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To evaluate the impact of genetic variations to apoptosis during progression of acquired immunodeficiency syndrome ( AIDS ) , we have performed an extensive genetic analysis of Fas and Fas ligand ( FasL ) genes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We assessed the effects of the following prostanoids : PGE ( 2 ) , PGF ( 2alpha ) , thromboxane A ( 2 ) mimetic ( U 46619 ) , and carbacyclin , a stable prostacyclin analogue ( all at 1 microM ) ; NSAIDs : indomethacin ( 150 microM ) or nimesulide ( 100 microM ) ; and Fas ligand ( 5 ng / mL ) . ^^^ Fas ligand stimulated IL 6 secretion ( 3 . 06 + / 0 . 38 fmol / mg wet weight per 3 hours , P < . 05 ) . ^^^ The magnitude of the effect of Fas ligand in the presence of NSAIDs depended on whether the placentas were delivered before or after labor . ^^^ CONCLUSION : Prostanoids , NSAIDs , and the Fas ligand regulate placental IL 6 secretion . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Lumican suppresses cell proliferation and aids Fas Fas ligand mediated apoptosis : implications in the cornea . ^^^ The Lum ( / ) MEF fail to induce Fas upon treatment with Fas ligand . ^^^ Fas Fas ligand interaction is an initiating event in apoptosis and its disruption in lumican deficiency may partly explain the observed decrease in apoptosis . ^^^ Fas Fas ligand mediated apoptosis is critical for maintaining the immune privileged status of the cornea , which implies a new and exciting role for lumican in the cornea . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tumour induced apoptosis in human mesothelial cells : a mechanism of peritoneal invasion by Fas Ligand / Fas interaction . ^^^ We examined the role of tumour cell induced mesothelial apoptosis and explored the role of the death ligand / receptor system , Fas Ligand / Fas , as mediators of the apoptotic process . ^^^ Human mesothelial cells and SW 480 tumour cells constitutively expressed Fas and Fas Ligand mRNA and protein as determined by RT PCR and confocal fluorescent microscopy . ^^^ Stimulation of human mesothelial cells with anti Fas monoclonal antibody or crosslinked soluble Fas Ligand induced apoptosis , confirming the functional status of the Fas receptor . ^^^ Pretreatment of SW 480 cells with a blocking recombinant anti Fas Ligand monoclonal antibody significantly reduced mesothelial apoptosis , indicating that tumour induced mesothelial apoptosis may , in part , be mediated via a Fas dependent mechanism . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Alterations in Fas ( CD 95 / Apo 1 ) and Fas ligand ( CD 178 ) expression in acute promyelocytic leukemia during treatment with ATRA . ^^^ Data from in vivo and in vitro studies have demonstrated that during ATRA treatment of APL there are significant changes not only in the expression of the apoptotic molecules Fas and Fas ligand , but also in the expression of other molecules involved both in the regulation of apoptosis and in interactions between host immune and leukemia cells . ^^^ We focus on ATRA induced changes in apoptotic pathways , particularly as it relates to the Fas / Fas ligand system . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Specific strategies for autoimmune diseases might include interference with cross priming events that activate autoreactive T cells and genetic engineering to introduce molecules that have immunosuppressive functions , such as IL 10 , TGF 3 , Fas ligand , ILT 3 , and ILT 4 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Decreased circulating Fas ligand in patients with familial combined hyperlipidemia or carotid atherosclerosis : normalization by atorvastatin . ^^^ OBJECTIVES : We sought to study whether patients with familial combined hyperlipidemia ( FCH ) or carotid atherosclerosis have modified circulating solubilized Fas ligand ( sFasL ) levels , as well as the potential modifications by atorvastatin . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Estradiol increased the number of apoptotic cells in tumors by 23 % ( 95 % CI = 20 % to 26 % ; P < . 001 ) compared with all other treatments , decreased estrogen receptor alpha ( ERalpha ) protein expression , increased the expression of Fas mRNA and protein , decreased the expression of HER2 / neu mRNA and protein and nuclear factor kappaB ( NF kappaB ) protein but did not affect Fas ligand protein expression compared with control . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NK 92 SCF cells exerted stronger cytotoxicity against a broad range of target tumor cells than their parent NK 92 cells , which was correlated to the increased expression of cytotoxic effector molecules such as perforin and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Protein expression of Fas , Fas ligand , Bcl 2 and TGFbeta 2 and correlation with survival in initial and recurrent human gliomas . ^^^ Several studies have recently demonstrated that human gliomas express Fas , Fas ligand ( FasL ) , Bcl 2 and TGFbeta 2 at some degree . ^^^ Pilocytic astrocytomas showed significantly higher scores of TGFbeta 2 expression ( p < 0 . 05 ) and significantly lower Fas , Fas ligand and Bcl 2 scores ( p < 0 . 05 ) than glioblastomas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We also investigated the effect of haem oxygenases on apoptosis of granulosa cells ( flow cytometry to detect subdiploid DNA fluorescence ) and on expression of Fas ligand ( quantitative analysis of western blotting and flow cytometry ) . ^^^ The quantity of Fas ligand protein was increased in a dose dependent manner in tightly bound PGCs treated with haemin compared with controls , and the haemin induced increase in Fas ligand protein was inhibited by ZnPP 9 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Regulation of Fas ligand expression by vascular endothelial growth factor in endometrial stromal cells in vitro . ^^^ When Fas ligand ( FasL ) interacts with the Fas receptor , it induces apoptosis through autocrine and / or paracrine signalling . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Donor T cells lacking Fas ligand and perforin retain the capacity to induce severe GvHD in minor histocompatibility antigen mismatched bone marrow transplantation recipients . ^^^ Cytotoxically double deficient ( B 6 cdd ) T cells ( lacking functional fas ligand and perforin ) and wild type ( B 6 wt ) donor T cell transplantation in a minor antigen mismatched BMT model ( C57BL / 6 > C3H . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas , Fas ligand ( FasL ) , and Fas associating death domain containing protein ( FADD ) were clearly up regulated within 48 hours of T treatment in HK 2 cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Lipopolysaccharides induced increases in Fas ligand expression by Kupffer cells via mechanisms dependent on reactive oxygen species . ^^^ Fas Fas ligand ( FasL ) dependent pathways exert a suppressive effect on inflammatory responses in immune privileged organs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tumoral cells expressing Fas ligand ( FasL ) have been proposed to `` counterattack ' ' against activated antitumoral effector immune cells , although some authors have indicated that FasL is not expressed on the surface of the same tumors , such in the case of melanoma cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Mechanisms of tolerance induced by transforming growth factor beta treated antigen presenting cells : CD 8 regulatory T cells inhibit the effector phase of the immune response in primed mice through a mechanism involving Fas ligand . ^^^ On the other hand , our data showed that the Fas Fas ligand ( FasL ) pathway was involved in this form of tolerance since TGF beta treated APC could not mediate tolerance in primed FasL deficient mice and CD 8 T cells from FasL deficient mice were unable to suppress effector T cell responses . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here we confirm that both HL derived cell lines and the HRS cells of primary HL tissues express Fas ligand ( FasL ) along with the inhibitory c FLIP protein . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here , we demonstrate that in human epithelia HeLa cells both mitochondrion and death receptor mediated apoptosis inducers [ staurosporine and Fas ligand or tumor necrosis factor ( TNF ) alpha ] rapidly activate Cl ( ) currents that show properties phenotypical of volume sensitive outwardly rectifying Cl ( ) channel currents , including outward rectification , voltage dependent inactivation gating at large positive potentials , inhibition by osmotic shrinkage , sensitivity to classic Cl ( ) channel blockers , and dependence on cytosolic ATP . ^^^ Staurosporine , but not Fas ligand or TNF alpha , rapidly ( within 30 min ) increased the intracellular level of reactive oxygen species ( ROS ) . ^^^ A ROS scavenger and an NAD ( P ) H oxidase inhibitor blocked the current activation by staurosporine but not by Fas ligand or TNF alpha . ^^^ Thus , it is concluded that an apoptosis triggering anion conductance is carried by the volume sensitive outwardly rectifying Cl ( ) channel and that the channel activation on apoptotic stimulation with staurosporine , but not with Fas ligand or TNF alpha , is mediated by ROS . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This study was undertaken to test the hypothesis that zinc interferes with an important Fas ligand mediated pathway in the liver , leading to the inhibition of ethanol induced apoptosis . ^^^ Immunohistochemical analysis revealed that zinc inhibited ethanol induced endogenous Fas ligand activation , which is a key component in signaling pathways leading to hepatic caspase 8 and subsequent caspase 3 activation and apoptosis . ^^^ These results demonstrate that zinc is a potent inhibitor of acute ethanol induced liver apoptosis , and this effect occurs primarily through zinc interference with Fas ligand pathway and the suppression of caspase 3 . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
High endothelial venules of the lymph nodes express Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This conclusion was supported by the following findings : 1 ) A 24 h treatment with IL 12 plus IL 18 enhanced Fas expression and annexin staining among basophil precursor enriched lin ( ) c kit ( ) splenocytes . 2 ) Fas or Fas ligand deficiency in mutant mice abolished the inhibitory effect of IL 12 plus IL 18 on IL 3 induced histamine production . 3 ) The large spectrum inhibitor of the caspase cascade , benzyloxycarbonyl Val Ala Asp fluoromethylketone , significantly reduced the effect of IL 12 plus IL 18 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Gene array and immunostaining of apoptosis related genes showed that Fas ligand expression was higher in C 5 s . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recently , the involvement of metalloproteinases in resistance to chemotherapy was suggested through their interaction with the Fas / Fas ligand pathway . ^^^ Indeed metalloproteinases enhance Fas ligand shedding modulating chemotherapy efficiency . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Changes of soluble fas and soluble fas ligand in serum and peritoneal fluid of infertile patients with endometriosis . ^^^ OBJECTIVE : To evaluate the relationship between levels of soluble Fas ( sFas ) and soluble Fas ligand ( sFasL ) in serum and peritoneal fluid of endometriosis associated infertility . ^^^ METHODS : The soluble Fas ligand and soluble Fas levels in serum and peritoneal fluid of 20 infertile patients with endometriosis were assessed with enzyme linked immunosorbent assay , and were compared with 14 infertile patients due to chronic pelvic infectious disease and 16 fertile controls . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
An enhancement in Fas / APO 1 and its two form ligands , membrane bound Fas ligand and soluble Fas ligand , as well as Bax protein , was responsible for the apoptotic effect induced by acacetin . ^^^ Taken together , our study suggests that the induction of p 53 and activity of the Fas / Fas ligand apoptotic system may participate in the antiproliferative activity of acacetin in Hep G 2 cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The administration of TPN also significantly increased IEL derived IFN gamma and Fas ligand ( FasL ) expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : The presence of mRNA coding for Fas , Fas ligand ( FasL ) , and TNF related apoptosis inducing ligand ( TRAIL ) was investigated in vitreous samples from 46 consecutive patients 25 with PVR , 11 with retinal detachment ( RD ) not complicated by PVR , and 10 with macular hole ( MH ) using RT PCR . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL ) mediated cytotoxicity is initiated in natural killer ( NK ) cells through ligation of their activating receptors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Variations in the serum concentrations of soluble Fas and soluble Fas ligand in Vietnamese patients infected with hepatitis B virus . ^^^ The serum concentrations of sFas and soluble Fas ligand ( sFasL ) was examined in both healthy and HBV infected Vietnamese patients to determine their relationship with the outcome of HBV infection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Elimination of activated but not resting primary human CD4+ and CD8+ T cells by Fas ligand ( FasL / CD95L ) expressing Killer dendritic cells . ^^^ Dendritic cells ( DC ) genetically engineered to express high levels of Fas ligand ( FasL / CD95L ) have been demonstrated to delete T cells in an antigen specific manner in several different animal models in vivo . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression and application of human Fas ligand in E . coli ] . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TALL 104 cells do not express Fas ligand , even upon coincubation with glioma targets , which suggests that the Fas / Fas ligand apoptotic pathway is not likely responsible for the cell injury observed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , the gene expressions of Fas receptor and Fas ligand , but not p 53 , were also induced in HL 60 cells dose and time dependently . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
After verification of apoptosis by annexin 5 staining and TUNEL assay , cell lines were characterized regarding their constitutive expression of both surface and soluble ( s ) Fas ( CD 95 ) and Fas ligand ( Fas L ) . ^^^ Paclitaxel treatment of breast cancer cell lines modulates Fas / Fas ligand expression and induces apoptosis which can be inhibited through the CD 40 receptor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand : Expression and soluble circulating levels in bile duct carcinoma . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Whereas IL 7 enhances NK function through upregulation of Fas ligand , the effect of IL 15 is mediated through upregulation of tumor necrosis factor related apoptosis inducing ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
After biopsy tissue RNA isolation , reverse transcription and polymerase chain reaction ( RT PCR ) for the glyceraldehyde 3 phospate dehydrogenase ( GAPDH ) , perforin , granzyme B and Fas ligand genes were performed . ^^^ Fas ligand was expressed in seven specimens , and six of them were classified as SAR ( p < 0 . 01 ) . ^^^ Granzyme B and Fas ligand had specificity of 90 % . ^^^ Fas ligand expression was observed in five samples , four of which had histological signs of SAR ( p = 0 . 03 ) . ^^^ At 12 months , perforin expression had the highest sensitivity ( 83 % ) , and Fas ligand , the highest specificity ( 88 % ) for the diagnosis of SAR . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This paper will analyze cytotoxicity assays that show that T cells challenge syngeneic , non cognate bystanders with Fas ligand ( FasL ) , and why syngeny is a requirement for danger reference cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cultivation of immobilized Dictyostelium discoideum for the production of soluble human Fas ligand . ^^^ Dictyostelium discoideum was immobilized by cultivation on inorganic porous matrices consisting of broken pumice or a ceramic catalyst carrier ( CeramTec ) to produce human soluble Fas ligand ( hFasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand cytokine levels correlated with expression of both caspase 3 and 2 , suggesting a link in the apoptotic `` death cascade . ' ' Caspase 3 activity also bore a close relationship to LV meridional wall stress calculated from echocardiographic and intraventricular pressure measurements . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We also found that compared with NNK treated WT mice , CC 10 KO mice manifest increased frequency of K ras mutation , elevated level of Fas ligand ( FasL ) expression , and increased MAPK / Erk phosphorylation , all of which are considered predisposing events in NNK induced lung tumorigenesis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , in the context of an extensive tumor burden , chronic stimulation of such CD 4 ( + ) T cells often leads to the up regulation of both Fas and Fas ligand , and coexpression of these molecules can potentially result in activation induced cell death and the subsequent loss of effector activity . ^^^ To evaluate the importance of T cell persistence in an experimental model of immunotherapy , we used DO 11 Th1 cells from wild type , Fas deficient , and Fas ligand deficient mice as effector populations specific for a model tumor Ag consisting of an OVA derived transmembrane fusion protein . ^^^ Importantly , both Fas and Fas ligand deficient Th 1 cells delayed tumor growth and cause regression of established tumors more effectively than wild type Th 1 cells , indicating that resistance to activation induced cell death significantly enhances T cell effector activity . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The role of Fas ligand and transforming growth factor beta in tumor progression : molecular mechanisms of immune privilege via Fas mediated apoptosis and potential targets for cancer therapy . ^^^ Despite the fact that expression of Fas ligand ( FasL ) in cytotoxic T lymphocytes ( CTLs ) and in natural killer ( NK ) cells plays an important role in Fas mediated tumor killing , During tumor progression FasL expressing tumor cells are involved in counterattacking to kill tumor infiltrating lymphocytes ( TILs ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Autoimmune Lymphoproliferative Syndrome ( ALPS ) is generally the result of a mutation in genes associated with apoptosis , like Fas , Fas ligand , Casp 8 and Casp 10 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas ( CD 95 ) / Fas ligand ( CD 178 ) system plays an important role in epithelial damage during the acute respiratory distress syndrome . ^^^ The goal of this study was to determine whether proximal and distal human lung epithelial cells differ in their sensitivity to Fas ligand ( rh sFasL ) , and whether the response of lung epithelium to Fas ligation is modulated by proinflammatory cytokines . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In our model , Fas ligand ( CD95L ) appears to play a limited role in lyssavirus mediated neuroblastoma cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Other regions demonstrated apoptotic lymphocytes with activation of a death receptor dependent cell pathway ( Fas ligand ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Hepatitis B virus 10 protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here , we report that the CD 4 molecule plays a direct role in CD 8 ( + ) T cell function by modulating expression of IFN gamma and Fas ligand , two important CD 8 ( + ) T cell effector molecules . ^^^ CD 4 expression also allows infection of CD 8 cells by HIV , which results in down regulation of the CD 4 molecule and impairs the induction of IFN gamma , Fas ligand , and the cytotoxic responses of activated CD 8 ( + ) T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Single base oligodeoxyguanosine upregulates Fas ligand release by nonspecific cytotoxic cells . ^^^ In vitro treatment of purified NCC with dG 20 produced a 7 fold increase in expression of soluble Fas ligand ( sFasL ) after 3 h . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Endothelial overexpression of Fas ligand decreases atherosclerosis in apolipoprotein E deficient mice . ^^^ OBJECTIVE : Fas ligand ( FasL ) can induce apoptosis in cells bearing the Fas receptor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Role of the Fas / Fas ligand death receptor pathway in ginseng saponin metabolite induced apoptosis in HepG 2 cells . ^^^ Based on these results , the involvement of the Fas / Fas ligand ( FasL ) death receptor pathway , in IH 901 induced apoptosis in HepG 2 cells , was investigated . ^^^ Levels of Fas and the Fas ligand ( FasL ) mRNA or protein were not increased by IH 901 , rather they were decreased significantly at 18 h post treatment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Further , TNF alpha , transforming growth factor ( TGF ) beta and soluble Fas ligand ( sFasL ) concentrations in culture supernatants of the cells were assessed by enzyme linked immunosorbent assay ( ELISA ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expressions of TNF alpha , interferon gamma ( IFN gamma ) , Fas and Fas ligand ( FasL ) mRNA in the livers were measured by RT PCR . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Another important feature of IL 18 is its ability to induce apoptosis of many cell types by inducing Fas ligand and Fas receptor , and granzymes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Herpes simplex virus 1 encodes at least four genes whose functions include blocking apoptosis induced by exogenous agents ( e . g . , sorbitol , Fas ligand , and BAD protein ) or replication incompetent mutants ( e . g . , the d 120 mutant lacking both copies of the alpha 4 gene ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunization for the treatment of cancer requires an adjuvant , a source of tumor associated antigen ( s ) , for example apoptotic cancer cells , and a way to overcome the escape of tumor cells from the immune system , for example the up regulation of Fas ligand ( FasL ) on the surface of cancer cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Regulation of interleukin 2 induced soluble Fas ligand release from human peripheral blood mononuclear cells . ^^^ We therefore investigated the regulation of IL 2 induced release of soluble Fas Ligand ( sFasL ) , since this factor is known to possess anti tumor activities . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recently , the Fas Ligand has been detected on the surface of cytotoxic T cells , and is thought to induce cells to apoptosis by adhering to the Fas antigen . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Plasma levels of soluble Fas ligand ( P = 0 . 028 ) and caspase 1 ( P = 0 . 037 ) , determined by enzyme linked immunosorbent assay , were increased during bronchiolitis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cervical cancer cells were transfected with a newly discovered interleukin ( IL ) 18 receptor to investigate the effect of endogenous IL 18 on the regulation of immune related factors such as Fas ( CD95 / Apo 1 ) / Fas ligand and intercellular adhesion molecules . ^^^ Transfection of the IL 18 receptor selectively induced a slight enhancement of the Fas via the up regulation of intracellular reactive oxygen species and IL 18 in cervical carcinoma C33A cells , whereas there were no effects on the expression of p 53 , intercellular adhesion molecules 1 and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tumor infiltrating lymphocytes ( TIL ) are often documented , however , their function is impaired by inhibitory cytokines , increased regulatory T lymphocyte activity , tumor cell MHC molecule alterations , and aberrant Fas ligand expression , amongst others . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Vitamin D inhibits Fas ligand induced apoptosis in human osteoblasts by regulating components of both the mitochondrial and Fas related pathways . ^^^ Human osteoblasts express the Fas receptor on their surface and its interaction with Fas ligand has been closely associated with human osteoblast apoptosis . ^^^ In summary , these results demonstrate that the anti apoptotic effect of 1 , 25 ( OH ) 2D3 in human osteoblasts after the activation of Fas ligand is mediated by the regulation of components of both the mitochondrial and Fas related pathways . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recent data from animal experiments suggest that cytokines , in particular Fas ligand ( FasL ) , contribute to postmenopausal osteoporosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interestingly , the hepatic injury was exacerbated in LECT 2 ( / ) mice upon treatment with Con A , possibly because of the significantly higher expression of IL 4 and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Chronically activated T cells undergo activation induced cell death ( AICD ) , which depends on simultaneous Fas and Fas ligand expression . ^^^ Our results show that inhibition of cyclin B 1 blocks AICD in T cells through specific inhibition of Fas ligand expression but not Fas induced apoptosis . ^^^ This effect of cyclin B 1 appears to be mediated through the cyclin B1 / cyclin dependent kinase 1 ( Cdk1 / Cdc2 ) complex because overexpression of cyclin B 1 enhances FasL promoter activity , whereas a dominant negative version of Cdk 1 blocks Fas ligand promoter induction . ^^^ In conclusion , our data support a link between cell cycle progression , activation induced Fas ligand expression , and apoptosis in T cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although Fas ligand ( L ) defect accounts for the progressive accumulation of abnormal DN T cells , the existence of other mechanisms which may be involved in the defective homeostasis in gld mice has been unclear . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A study of promoter and intronic markers of ApoI / Fas gene and the interaction with Fas ligand in relapsing multiple sclerosis . ^^^ We also analyzed the interaction of this new intragenic marker with others previously associated with MS : class 2 HLA DRB1 * 1501 , Fas MvaI and Fas ligand . ^^^ The case / control comparative study showed a relative risk ( OR close to 1 . 6 ) of MS in individuals harboring the T and A alleles of Fas MaeI and Fas ligand , respectively . ^^^ In conclusion , our findings suggest a weak association between the intronic marker Fas MaeI and MS and a relative interaction with Fas ligand in an MS cohort of South Spanish extraction . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
An enhancement in Fas / APO 1 and its two form ligands , membrane bound Fas ligand ( mFasL ) and soluble Fas ligand ( sFasL ) , as well as Bax protein , was responsible for the apoptotic effect induced by Saikosaponin D . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We also show that both parental cells and M 125 constitutively express Fas ligand and TNF related apoptosis inducing ligand , thus pre disposing cells to apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( CD 95 ) and Fas ligand ( FasL , CD95L ) have been implicated to be involved in the acute inflammatory response by attracting neutrophils and regulating their survival . ^^^ Inflammatory response during bacterial meningitis is unchanged in Fas and Fas ligand deficient mice . ^^^ Fas ( CD 95 ) and Fas ligand ( FasL , CD95L ) have been implicated to be involved in the acute inflammatory response by attracting neutrophils and regulating their survival . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Finally , ROS and lipid peroxidation increase the generation of several cytokines ( TNF alpha , TGF B , Fas ligand ) that play sundry roles in the pathogenesis of NASH . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , no significant treatment associated changes were observed in Bid , Fas , Fas ligand , p 53 , and caspase 8 and 10 proteins in either placenta or uterus . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunohistochemical studies revealed the expression of Fas ligand ( Fas L ) , Bax and interleukin 1 beta converting enzyme ( ICE ) in the renal tubular epithelium of the descending limb of loop of Henle and the distal convoluted tubules . mRNA of the ICE , c myc , p 53 and Fas L genes was also upregulated in the kidneys of the stone forming rats . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
An enhancement in Fas and its two ligands , namely membrane bound Fas ligand ( mFasL ) and soluble Fas ligand ( sFasL ) , may be responsible for the apoptotic effect induced by ISL . 4 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TCR crosslinking induced oxidase activation through the recruitment of preformed Fas ligand and Fas . ^^^ TCR stimulation induced three separable events generating reactive oxygen species : rapid hydrogen peroxide production independent of Fas or NADPH oxidase ; sustained hydrogen peroxide production dependent on both Fas and NADPH oxidase ; and delayed superoxide production that was dependent on Fas ligand and Fas yet independent of NADPH oxidase . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Adenovirus expressing Fas ligand gene decreases airway hyper responsiveness and eosinophilia in a murine model of asthma . ^^^ The normal resolution of inflammation in the lung occurs through the regulated removal of unneeded cells by Fas Fas ligand mediated apoptosis . ^^^ Fas ligand ( FasL ) is a member of the tumor necrosis factor family , and when bound to Fas , it induces apoptosis of the cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Similarly , soluble Fas ligand ( sFasL ) was detected in CM of cultures of SW 480 cells expressing FasL after treatment with SpeB activated proMMPs ; this CM also induced apoptosis in U 937 cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Colorectal cancer cells are unique in that they escape Fas mediated cell death in the presence of Fas ligand , and we recently reported that AMP activated protein kinase related kinase 5 ( ARK 5 ) suppresses cell death signaling mediated by cell death receptor in Akt dependent manner . ^^^ Interestingly , SW 480 and SW 1116 cell lines , but not LoVo cell line , showed expressions of both Fas ligand ( FasL ) and Fas mRNAs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : Fas ( APO 1 / CD95 ) is a cell surface receptor that mediates apoptosis when it reacts with Fas ligand ( FasL ) or Fas antibody . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunohistochemical techniques were used with antibodies directed against glial fibrillary acidic protein ( GFAP ) , caspase 3 , Fas , Fas ligand ( FasL ) , Bax , Bcl 2 , survivin , p 53 , extracellular signal regulated kinases ( ERK1 / 2 ) , and p 38 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
ECH ( epoxycyclohexenone ) specifically blocks death receptor mediated apoptosis induced by anti Fas antibody , Fas ligand , or TNF alpha , whereas it has no effect on death receptor independent apoptosis induced by staurosporine , MG 132 , C 2 ceramide , or UV irradiation . ^^^ In Fas ligand treated cells , ECH is only able to inhibit the activation of pro caspase 8 and it has no effect on the already activated caspase 8 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Human trophoblast and decidualized endometrial cells also express Fas ligand ( FasL ) , a pro apoptotic molecule . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Normal spontaneous apoptosis in neutrophils is enhanced by `` stress ' ' stimuli such as tumor necrosis factor alpha , Fas ligand , and oxidants , and this effect is inhibited by anti apoptotic stimuli including granulocyte macrophage colony stimulating factor , lipopolysaccharide , and formylmethionine leucine phenylalanine . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Triiodothyronine down regulates Fas and Fas ligand expression and suppresses caspase 3 and poly ( adenosine 5 ' diphosphate ribose ) polymerase cleavage and apoptosis in early placental extravillous trophoblasts in vitro . ^^^ The present study was conducted to determine whether T ( 3 ) receptor exists in early placental extravillous trophoblasts ( EVTs ) and evaluate the influence of T ( 3 ) on Fas / Fas ligand expression , caspase 3 , and poly ( ADP ribose ) polymerase ( PARP ) cleavage and apoptosis in cultured early placental EVTs . ^^^ Fas and Fas ligand expression and caspase 3 and PARP cleavage were evaluated by immunocytochemistry . ^^^ Treatment with T ( 3 ) reduced the expression of Fas and Fas ligand as well as cleavage of caspase 3 and PARP and suppressed apoptosis in cultured EVTs . ^^^ These results demonstrate that T ( 3 ) receptor is present in early placental EVTs and that T ( 3 ) suppresses apoptosis by down regulating the expression of Fas and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CTLL 2 cell viability was measured using MTT assay when co cultured with mouse T cell leukemia cell line EL 4 cells that highly expressed Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand is expressed in activated T cells and represents a major cytotoxic effector mechanism by which T cells kill their target cells . ^^^ Activation induced Fas ligand expression in T cells is under the stringent control of various transcription factors , including nuclear factor kappaB ( NFkappaB ) and c Myc / Max . ^^^ There is accumulating evidence that Fas ligand is also expressed by various non hematopoietic tumor cells , however , little is known about Fas ligand regulation in tumor cells . ^^^ In this study , we have analyzed the regulation of the Fas ligand gene promoter induction in two non small cell lung cancer cell lines , with a major focus on the role of the c Myc / Max transcription factor . ^^^ Our results revealed that inhibition of c Myc / Max did not substantially reduce basal levels of Fas ligand promoter activity , nor did overexpression of c Myc significantly induce promoter activity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas but not Fas ligand on fetal pig beta cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Local adenoviral expression of Fas ligand upregulates pro inflammatory immune responses in the CNS . ^^^ Fas ligand ( FasL ) contributes to the immune privilege of certain tissues by inducing apoptosis in activated T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased cytotoxicity of soluble Fas ligand by fusing isoleucine zipper motif . ^^^ We successfully constructed a chimeric soluble FasL by fusing an isoleucine zipper motif for self oligomerization and a FLAG sequence to the extracellular domain of the human Fas ligand ( FIZ shFasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Vulnerability of mouse cortical neurons to doxorubicin induced apoptosis is strain dependent and is correlated with mRNAs encoding Fas , Fas Ligand , and metalloproteinases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL ) , and its receptor Fas are essential in the homeostasis of the peripheral immune system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
There were significant differences in the concentrations of IL 10 , IL 12 , and soluble Fas ligand between AD patients and normal controls . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Relative to control co stimulated Th1 / Tc1 ( T 1 ) cells , co stimulated T 2 cells secreted reduced interleukin ( IL ) 2 and interferon gamma and increased IL 4 and IL 10 , expressed reduced fas ligand , and had similar total cytolytic capacity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here , we studied the expression of genes for interferon gamma ( IFN gamma ) and molecules involved in lymphocyte mediated cytotoxicity [ granzyme B ( grzB ) , perforin , granulysin and Fas ligand ( FasL ) ] against M . tuberculosis infected macrophages . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Preliminary experiments in gld mice that express nonfunctional Fas ligand ( FasL ) revealed that RSV induced illness is significantly reduced in the absence of FasL mediated killing . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Lymphocytes treated with clarithromycin , azithromycin and josamycin at a final concentration of 200 microg / ml showed positive staining for Annexin 5 , Fas and Fas ligand using flow cytometry with time at 12 72 h , while other antibiotics did not . ^^^ Our results suggest that macrolides induce apoptosis of lymphocytes through Fas Fas ligand pathway and could potentially reduce the number of lymphocytes in the lungs of patients with chronic lower respiratory tract disease . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Involvement of p 53 , nuclear factor kappaB and Fas / Fas ligand in induction of apoptosis and cell cycle arrest by saikosaponin d in human hepatoma cell lines . ^^^ In addition , an enhancement in Fas / APO 1 and its two form ligands , membrane bound Fas ligand ( mFasL ) and soluble Fas ligand ( sFasL ) , as well as Bax protein , was responsible for the apoptotic effect induced by saikosaponin d . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Studies in nonhuman primates have demonstrated that elevation of the cytotoxic lymphocyte ( CL ) genes granzyme B , perforin , and Fas ligand in peripheral blood precedes islet allograft rejection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand induces cell autonomous NF kappaB activation and interleukin 8 production by a mechanism distinct from that of tumor necrosis factor alpha . ^^^ Fas ligand ( FasL ) has been well characterized as a death factor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , treatment with 20 microM gamma tocotrienol had no effect on total , membrane , or cytosolic levels of Fas , Fas ligand ( FasL ) , or Fas associated via death domain ( FADD ) and did not induce translocation of Fas , FasL , or FADD from the cytosolic to the membrane fraction , providing additional evidence that tocotrienol induced caspase 8 activation is not associated with death receptor apoptotic signaling . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , CD4+ cytotoxic T lymphocytes ( CTLs ) can kill CLL B cells via a Fas ligand ( CD 178 ) dependent process within 24 hours after CD 40 cross linking , when ligation of CD 95 alone is insufficient to induce apoptosis . ^^^ Fas ligand ( CD 178 ) and TRAIL synergistically induce apoptosis of CD 40 activated chronic lymphocytic leukemia B cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Among these silenced genes , Kruppel like factor 4 ( KLF 4 ) gene is a cell cycle regulator and early growth response 3 ( EGR 3 ) gene is a critical transcriptional factor for induction of Fas ligand ( FasL ) expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Attempts at inducing allograft immune privilege by enforced Fas ligand expression have shown accelerated rejection mediated by neutrophils . ^^^ While it has been proposed that Fas ligand was directly chemotactic toward neutrophils , several lines of evidence argue for an indirect recruitment mechanism . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Levels of serum neopterin , anti dsDNA antibodies , C 3 , C 4 complement components , nucleosomes antibodies , IL 10 , fas ligand , soluble thrombomodulin , sVCAM 1 , and sICAM 1 were measured in a group of 52 patients with SLE . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This effect was found to correlate with the up regulation of Fas / APO 1 , Fas ligand , and Bax , and down regulation of NF kappaB , Bcl 2 , and Bcl XL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
After cell isolation , cell based apoptosis markers annexin 5 , Fas receptor , and Fas ligand were measured by flow cytometry . ^^^ Whereas the Fas receptor peaked at 1 h , Fas ligand was increased 3 h after the run . ^^^ After the treadmill tests Fas receptor expression was enhanced in both groups , whereas Fas ligand increased only after the ExT . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We have previously demonstrated that , in fetal rabbits , developmental type 2 cell apoptosis coincides with transient upregulation of the cell death regulator Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas Fas ligand interactions are essential for the binding to and killing of activated macrophages by gamma delta T cells . ^^^ Using a macrophage T cell coculture system in which peritoneal macrophages from naive or Lm infected TCRdelta / mice were incubated with splenocytes from wild type and Fas ligand ( FasL ) deficient mice ( gld ) , the ability of Vgamma 1 T cells to bind macrophages was shown to be dependent upon Fas FasL interactions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Markers of T cells and immune mediated cytotoxicity that accumulate in recovering liver were not apparent in WPH based on the relative lack of CD 3 , CD 4 , Fas ligand , perforin , and granzyme B mRNAs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand levels ( but not Fas ) were also significantly reduced in this group . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand but not Fas expression was also reduced . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Renal tubular epithelial cell self injury through Fas / Fas ligand interaction promotes renal allograft injury . ^^^ Tubular epithelial cells ( TECs ) coexpress Fas and Fas ligand ( FasL ) , which could influence renal allograft injury . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression levels of cytokines , Fas antigen , and Fas ligand ( TaqMan quantitation ) in PBMC from infected patients were not significantly different from those in uninfected patients ( treated in the same isolation wards ) , nor was there a significant increase in expression compared to healthy volunteers ( United States ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activation of tumor necrosis factor receptor 1 or Fas leads to the generation of reactive oxygen species , which are important to the cytotoxic effects of tumor necrosis factor alpha ( TNF alpha ) or Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Dimethyl 2 , 2 dichlorovinyl phosphate ( DDVP ) markedly inhibits activities of natural killer cells , cytotoxic T lymphocytes and lymphokine activated killer cells via the Fas ligand / Fas pathway in perforin knockout ( PKO ) mice . ^^^ Natural killer ( NK ) , lymphokine activated killer ( LAK ) and cytotoxic T lymphocyte ( CTL ) cells induce target cell death by two main mechanisms , the perforin / granzyme pathway and the Fas ligand ( FasL ) / Fas pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : Forty three human renal allograft biopsies were quantified for mRNA expression of granzyme B , Fas ligand , interferon ( IFN ) gamma , interleukin ( IL ) 4 , and IL 6 with a reverse transcriptase real time quantitative polymerase chain reaction ( RT PCR ) method . ^^^ RESULTS : Granzyme B and Fas ligand mRNA expression up regulation correlated with all allograft rejection types ( P < 0 . 01 for all ) . ^^^ Curative antirejection therapy resistance of overt , acute rejection episode was significantly associated with higher Fas ligand gene expression ( AUC=0 . 764 , P < 0 . 01 , sensitivity [ 71 % ] , specificity [ 99 . 5 % ] ) . ^^^ Furthermore , we demonstrate that the simultaneous measurement of the mRNA up regulation of Fas ligand might represent an efficient new tool for the prediction of pejorative outcome of acute rejection . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 14 , CD 68 , Toll like receptor ( TLR ) 2 , TLR 4 and Fas ligand ( FasL ) were analysed immunohistochemically . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We sought to analyze cortical expression of interleukin ( IL ) 1beta , IL 6 , tumor necrosis factor ( TNF ) alpha , transforming growth factor ( TGF ) beta , Fas , and Fas ligand ( FasL ) mRNA after a transient , focal brain ischemia in rats subjected to preconditioning . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Autocrine secretion of Fas ligand shields tumor cells from Fas mediated killing by cytotoxic lymphocytes . ^^^ Metalloprotease inhibitors did not affect the expression of Fas but increased the surface expression of Fas ligand ( FasL ) , which correlated with the disappearance of soluble FasL from culture supernatants of tumor cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Critical roles for the Fas / Fas ligand system in postinfarction ventricular remodeling and heart failure . ^^^ Fas and Fas ligand were overexpressed in the granulation tissue at the subacute stage of MI ( 1 week after MI ) in mice , where apoptosis frequently occurred . ^^^ In mice lacking functioning Fas ( lpr strain ) and in those lacking Fas ligand ( gld strain ) , apoptotic rate of granulation tissue cells was significantly fewer compared with that of genetically controlled mice , and post MI ventricular remodeling and dysfunction were greatly attenuated . ^^^ Mice were transfected with adenovirus encoding soluble Fas ( sFas ) , a competitive inhibitor of Fas ligand , on the third day of MI . ^^^ The Fas / Fas ligand interaction plays a critical role for granulation tissue cell apoptosis after MI . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression in human pancreatic cancer . ^^^ Recently we reported that pancreatic cancer cell lines express Fas ligand and kill lymphoid cells by Fas mediated apoptosis in vitro . ^^^ This study was designed to determine whether human pancreatic tumors express Fas ligand in vivo , as a potential mediator of counterattacking the host immune cells , and to determine if Fas ligand expression correlates with clinicopathologic characteristics and patient survival . ^^^ Fas ligand expression in 45 primary pancreatic ductal cancers and two hepatic metastases was determined using immunohistochemistry . ^^^ Immunohistochemistry showed that 37 ( 82 % ) of the primary tumors and both of the hepatic metastases expressed Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Strong reactivity with three proteins ( approximate Mr 70 , 000 , 37 , 000 , and 15 , 000 ) was seen using an antibody targeted to mammalian Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand in retinoblastoma . ^^^ BACKGROUND : The importance of the Fas Fas ligand ( FasL ) mechanism for the immune evasion by tumors provided a strong rationale for the examination of FasL expression in retinoblastoma . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ontogenesis and cell specific localization of Fas ligand expression in the rat testis . ^^^ Over the past few years , a number of experimental evidences suggested the involvement of Fas Ligand ( FasL ) expressing Sertoli cells to induce apoptosis of Fas bearing germ cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
K 2 MDS cells expressed perforin and granzyme B , but they lacked Fas ligand expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
IL 12 induced substantial upregulation of Fas ligand ( FasL ) surface expression in ovarian carcinoma cells paralleled by an increased ability to induce apoptosis in Jurkat cells and PHA activated lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
At early times , Fas ligand ( fas L ) expression was significantly enhanced in sensitive compared to resistant cells and remained upregulated up to the onset of apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Essential role for hematopoietic Fas ligand ( FasL ) in the suppression of melanoma lung metastasis revealed in bone marrow chimeric mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Pulmonary , hepatic , and renal tissues were assessed for P2Y4 , P2Y6 , P2X7 , A 3 , and A2b receptor expression by real time reverse transcriptase polymerase chain reaction and Fas / Fas ligand mRNA was quantified in the lung . ^^^ Large volume MV increased A2b mRNA and decreased P2X7 in the lung ; mRNA changes in lung Fas ligand paralleled P2X7 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Because the Fas ligand / Fas receptor ( CD 95 , APO 1 ) apoptosis pathway is a potential therapeutic target in osteosarcomas , we examined the effect of IFN gamma on Fas induced apoptosis in four osteosarcoma cell lines . ^^^ Combined immunotherapy with IFN gamma and either anti Fas monoclonal antibody or cytotoxic T cells that bear Fas ligand might be a useful adjunctive therapy for patients with osteosarcoma . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Accelerated neutrophil apoptosis in neutropenic patients with hepatosplenic schistosomiasis is induced by serum Fas ligand . ^^^ Neutrophils from healthy subjects were also incubated with either 10 % heterologous normal or neutropenic serum , with and without anti Fas ligand antibody . ^^^ Serum Fas ligand levels were assessed in sera of patient groups and healthy controls by ELISA . ^^^ The apoptotic effect of neutropenic sera is attenuated by anti Fas ligand . ^^^ Serum Fas ligand levels were significantly higher among HS group as compared to both HI and control groups ( P < 0 . 01 for both ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Prognostic impact of Fas ligand on hepatocellular carcinoma after hepatectomy . ^^^ The expression of Fas ligand on tumor cells may counterattack the host ' s immunity and worsen the prognosis . ^^^ Knowledge of the prognostic impact of Fas ligand on patients with hepatocellular carcinoma ( HCC ) after hepatectomy is still limited . ^^^ Fas ligand expression in HCCs was examined in 59 patients who underwent hepatectomy for HCC . ^^^ The prognosis was analyzed and correlated to the expression of Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
FLICE inhibitory protein ( FLIP ) is an antiapoptotic protein that might prevent apoptotic elimination of FLS in response to death ligands such as tumor necrosis factor alpha ( TNFalpha ) or Fas ligand , which are present in RA synovium . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Role of soluble Fas ligand in autoimmune diseases . ^^^ AIM : To investigate the role of soluble Fas ligand in autoimmune diseases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
An enhancement in Fas / APO 1 and its two form ligands , membrane bound Fas ligand ( mFasL ) and soluble Fas ligand ( sFasL ) , might be responsible for the apoptotic effect induced by PB233 ' OG . ^^^ Our study reports here for the first time that the induction of p21 / WAF1 and activity of the Fas / Fas ligand apoptotic system may participate in the anti proliferative activity of PB233 ' OG in A 549 cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Staurosporine , but not a Fas ligand or H2O2 , significantly increased caspase activity , but only in high motility fractions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Both perforin and Fas ligand are required for the regulation of alloreactive CD8+ T cells during acute graft versus host disease . ^^^ Fas ligand ( FasL ) and perforin pathways not only are the major mechanisms of T cell mediated cytotoxicity but also are involved in homeostatic regulation of these T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Novel negative regulator of expression in Fas ligand ( CD 178 ) cytoplasmic tail : evidence for translational regulation and against Fas ligand retention in secretory lysosomes . ^^^ Fas ligand ( ( FasL ) CD 178 ) , a type 2 transmembrane protein , induces apoptosis of cells expressing the Fas receptor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Decoy receptor 3 ( DcR 3 ) / TR6 / M68 is a soluble receptor that binds to the Fas ligand LIGHT and TL1A . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , the reduced apoptosis was correlated with downregulation of Fas ligand and TNF receptor 1 expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This randomized , placebo controlled trial showed that levosimendan administration causes a significant reduction of circulating proinflammatory cytokine interleukin 6 and soluble apoptosis mediators , such as soluble Fas and Fas ligand in patients with decompensated heart failure . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Mesangial cell Fas ligand : upregulation in human lupus nephritis and NF kappaB mediated expression in cultured human mesangial cells . ^^^ BACKGROUND : Fas ligand ( FasL ) is a well known death factor ; however , the role of FasL in the regulation of human glomerulonephritis remains unclear . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interferon gamma ( IFN gamma ) , soluble tumor necrosis factor alpha ( TNF alpha ) , soluble Fas ligand ( sFas L ) were present in much higher concentration in the blister fluids of 13 toxic epidermal necrolysis ( TEN ) patients than in control fluids from burns . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This signaling defect leads to a reduced expression of Fas ligand ( FasL ) and to a reduction in AICD . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Induction of tolerance using Fas ligand : a double edged immunomodulator . ^^^ Apoptosis mediated by Fas ligand ( FasL ) interaction with Fas receptor plays a pivotal regulatory role in immune homeostasis , immune privilege , and self tolerance . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The central role of Fas ligand cell signaling in inflammatory lung diseases . ^^^ This review discusses evidence that proapoptotic Fas Fas ligand ( FasL ) signaling plays a central role in pulmonary inflammation , injury and fibrosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BCG immunization sequentially induced the production of TNF alpha , IFN gamma and IL 4 by splenocytes , increased the expression of Fas ( high ) ( Apo 1 / CD95 ) , Fas ligand ( FasL , CD95L ) and TNF receptor ( TNFR ) on T cells leading to T cell apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
FAP 1 , FasR , and Fas ligand ( FasL ) were detected using immunohistochemistry . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Caseamembrin C also induced the up regulation of Fas ligand ( FasL ) expression , cleavage and activation of caspase 8 and caspase 9 , Bid cleavage and activation of executor caspase 3 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
When IELs were stimulated with IL 15 , the CD 94 ( + ) IEL subset expanded and carried out cytotoxic activity in redirected lysis against P 815 cells as well as Fas ligand ( FL ) and tumour necrosis factor ( TNF ) alpha mediated lysis of Jurkat and WEHI cells , respectively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The results proved that PMNs are triggered by ICs resulting in the acceleration of the production of tumour necrosis factor alpha ( TNF alpha ) , perforin and Fas ligand , in which FcR on PMNs appears to be involved . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : Grade 1 ( non OA ) femoral condyles and tibial plateaus from mature and aged rabbits were taken for assessment of viable cell density ( VCD ) and mRNA ( reverse transcription polymerase chain reaction ) expression levels of the pro apoptotic genes , Fas , Fas ligand ( FasL ) , caspase 8 , inducible nitric oxide synthase ( iNOS ) and p 53 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Balanced regulation of mRNA production for Fas and Fas ligand in lymphocytes from centenarians : how the immune system starts its second century . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The kidneys were harvested 1 , 3 , or 7 days postoperatively , and tissue samples were subsequently analyzed for TNF alpha ( ELISA , RT PCR ) , Fas ligand ( RT PCR ) , apoptosis ( TUNEL , ELISA ) , and caspase 8 and 3 activity ( Western blot ) . ^^^ Renal obstruction induced increased tissue TNF alpha and Fas ligand mRNA levels , TNF alpha protein production , apoptotic renal tubular cell death , and elevated caspase 8 and 3 activity , whereas treatment with PEG sTNFR 1 significantly reduced obstruction induced TNF alpha production , renal tubular cell apoptosis , and caspase activity . ^^^ PEG sTNFR 1 did not significantly alter Fas ligand expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this report we questioned the current view that the two principal cytotoxic pathways , the exocytosis and the Fas ligand ( FasL ) / Fas mediated pathway , have largely nonoverlapping biological roles . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression on nucleus pulposus begins in developing embryo . ^^^ STUDY DESIGN : The expression of Fas ligand in the notochord or nucleus pulposus was examined immunohistochemically using rat embryos . ^^^ OBJECTIVE : To clarify at which stage of embryo development the expression of Fas ligand begins in the nucleus pulposus . ^^^ Immune privileged characteristics in other tissues , such as the retina and testis , have been attributed to the local expression of Fas ligand , which acts by inducing apoptosis of invading Fas positive T cells . ^^^ The authors reported previously on the expression of Fas ligand in nucleus pulposus cells of mature rats and humans , which could play a key role in the potential molecular mechanism of maintaining immune privilege of the disc . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Marked elevation of soluble fas ligand and cytokine secretion after splenectomy in aggressive natural killer cell leukemia / lymphoma . ^^^ The serum level of ferritin , triglycerides , interferon gamma ( IFN gamma ) , interleukin 10 ( IL 10 ) , and soluble Fas ligand ( sFasL ) increased markedly , and liver damage progressed after splenectomy . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In vitro efficacy of Fas ligand gene therapy for the treatment of bladder cancer . ^^^ As a result , we investigated the in vitro efficacy of Fas ligand gene therapy for bladder cancer . ^^^ Cells were also treated with a replication deficient adenovirus containing a modified murine Fas ligand gene fused to green fluorescent protein ( GFP ) , AdGFPFasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increase in serum concentration of FAS ligand as a possible mechanism for antithyroid cytotoxicity during autoimmune thyroid diseases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In 4 infected HCF , gene mRNA expression levels of interleukine ( IL ) 1beta , IL 6 , tumor necrosis factor ( TNF ) alpha , Fas ligand , interferon regulatory factor ( IRF ) 1 , interferon ( IFN ) alpha and IFN beta increased as compared with those in mock treatment cells , and the induction of mRNAs for double stranded RNA dependent protein kinase ( PKR ) , indolamine 2 , 3 deoxygenase ( IDO ) and 2 ' 5 ' oligoadenylate synthetase ( 2 5 OAS ) were indicated , which had a role for a host defense response induced by IFN beta . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We showed that expression of Fas and Fas ligand was upregulated and caspase 8 was significantly activated in CoCl ( 2 ) induced apoptotic cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Real time RT PCR revealed an increase in mRNA levels of Fas ligand ( Fas L ) , a membrane protein related to the TNF family , in cultured microglia following OGD exposure . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tendency to slightly increased percent of apoptotic and / or Fas Ligand cells reflects likely the local immunity alterations in asbestosis patients . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To identity the anti cancer mechanism of PB233 ' OG , we assayed its effect on apoptosis , cell cycle distribution , and levels of p 53 , p21 / WAF1 , Fas / APO 1 receptor and Fas ligand . ^^^ We suggest that Fas / Fas ligand apoptotic system is the main pathway of PB233 ' OG mediated apoptosis of MCF 7 cells . ^^^ Our study reports here for the first time that the activity of the Fas / Fas ligand apoptotic system may participate in the anti proliferative activity of PB233 ' OG in MCF 7 cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Spontaneous monocyte apoptosis is regulated by the death ligand , Fas Ligand ( FasL ) binding to its receptor Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cross Talk between Fas / Fas ligand system and nitric oxide in the pathway subserving granulosa cell apoptosis : a possible regulatory mechanism for ovarian follicle atresia . ^^^ Recent studies have shown the involvement of Fas / Fas ligand ( FasL ) system and nitric oxide ( NO ) in ovarian follicle atresia . ^^^ Here we asked whether Fas / Fas ligand system interacts with NO using rat granulosa cell culture . ^^^ Soluble recombinant Fas ligand ( rFasL ) , at 100 ng / ml , significantly decreased cell viability , as measured by 3 ( 4 , 5 dimethylthiazol 2 yl ) 5 ( 3 carboxymethoxyphenyl ) 2 ( 4 sulfophenyl ) 2H tetrazolium , inner salt ( MTS ) assay , in the presence of 200 U / ml interferon gamma , whereas the concurrent addition of a caspase inhibitor , Z VAD FMK , at 20 microm , significantly inhibited rFasL induced cytotoxicity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand as a tool for immunosuppression and generation of immune tolerance . ^^^ The role of Fas ligand ( FasL ) in physiologically limiting immune responses and maintaining immune privileged sites has led to a body of research aiming to confer protection to allogeneic grafts by expressing FasL on the allogeneic tissue or by administrating FasL transduced donor dendritic cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Western blot analyses were performed on cultured seminiferous tubule segments for Bcl 2 family proteins ( Bax , Bad , Bcl w , Bcl xL ) and fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Platelet induced modulation of inflammation and adaptive immune responses are mediated in part through tumor necrosis factor ( TNF ) family member ligands , including CD 154 , Fas ligand , and TNFalpha , that are expressed upon platelet activation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In previous studies we have shown that elevated glucose concentrations induce apoptosis in human beta cells due to an interaction between constitutively expressed Fas ligand and upregulated Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This clinical study compared the expression of circulating proinflammatory ( tumor necrosis factor alpha [ TNF alpha ] and interleukin 6 ) and anti inflammatory ( interleukin 10 ) cytokines and soluble apoptosis mediators ( Fas / Fas ligand ) between patients with stable chronic heart failure and depressive symptoms ( as estimated by the Zung Self Rating Depression Scale ) ( n = 15 ) and those without these symptoms ( n = 20 ) . ^^^ Patients with depressive symptoms exhibited significantly higher levels of TNF alpha and soluble Fas ligand , as well as significantly lower levels of interleukin 10 , than patients without emotional distress . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand is enriched in the caveolae membrane domains of thymic epithelial cells . ^^^ Both Fas and Fas ligand ( FasL ) are expressed in the thymus . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Pleural effusions drawn from 44 ( 18 non malignant and 26 malignant ) patients were tested for selected cytokines interleukin 10 ( IL 10 ) , transforming growth factor beta ( TGF beta 1 ) and soluble Fas ligand ( sFasL ) and nuclear membrane proteins ( NMPs ) content by ELISA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
By contrast , IL 18 required tumor sensitivity to Fas ligand ( FasL ) and surprisingly did not depend on the NKG2D NKG2D ligand pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RESULTS : At days 26 and 27 , the protein levels of Fas and Fas ligand ( FasL ) in lung lysates were similar in TO fetuses and sham operated controls . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Toxic epidermal necrolysis treated with low dose intravenous immunoglobulin : immunohistochemical study of Fas and Fas ligand expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Reintroduction of the AhR into the AhR negative BP 8 hepatoma cells as well as into primary hepatocytes from AhR knockout mice increases the magnitude of cell death in response to Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Upregulation of Fas / Fas ligand mediated apoptosis by gossypol in an immortalized human alveolar lung cancer cell line . ^^^ We also examined several factors that may affect apoptosis , including p 53 , p21 / WAF1 , Fas receptor , Fas ligand ( FasL ) and caspase 8 activity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this work , we sought to characterize the role of Fas Ligand ( FasL ) in liver injury during acute pancreatitis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunoprecipitation was performed to assess for FAS receptor / FAS ligand complex formation , and activation of caspase 8 and BID ( a member of the Bcl 2 family of proteins ) was assessed by Western blot analysis . ^^^ Specific pathway inhibition was performed with the caspase 9 inhibitor zLEHD . fmk or neutralizing antibodies against either the FAS receptor or FAS ligand . ^^^ RESULTS : Retinal detachment resulted in the time dependent formation of the FAS receptor / FAS ligand complex that preceded the peak of caspase 9 activity and caspase 9 / cytochrome c complex formation . ^^^ Retinal detachment resulted in the transcriptional upregulation of the FAS receptor , FAS ligand , caspase 8 and BID , but not caspase 9 and cytochrome c . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Therefore , we investigated the role of Fas ligand ( FasL ) and TRAIL in H . pylori mediated apoptosis by overexpressing antiapoptotic proteins in the human gastric epithelial cell line AGS . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Reverse transcription polymerase chain reaction analyses of the isolated jejunal epithelial fraction showed that the development of villus atrophy in euthymic rats was positively correlated with an increase of granzyme B transcript levels but not with Fas ligand or tumor necrosis factor alpha expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
There are many molecules , including Fas ligand ( FasL ) and cytokines , such as IL 1 , TNF alpha and IFN gamma that cause release of other cytokine mediators that have potential to damage the beta cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Staphylococcal enterotoxin A induced hepatotoxicity is predominantly mediated by Fas ligand ( CD95L ) . ^^^ OBJECTIVE : To determine the role of tumor necrosis factor alpha ( TNF alpha ) and Fas ligand ( FasL , CD95L ) in superantigen induced and endotoxin induced liver injury . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RESULTS : Both G603L cells and G603AD cells expressed Class 1 human leukocyte antigen , intracellular cell adhesion molecule 1 , and lymphocyte associated antigen type 3 ( LFA 3 ) , but not Fas or Fas ligand on their surfaces . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) family ligand TNF alpha and Fas ligand ( FasL ) can trigger apoptosis in solid tumors , but their clinical usage has been limited by hepatotoxicity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the first trimester , the receptor mediated pathway prevails over the mitochondrial pathway with a moderate / intense expression of its three components , viz . , Fas ligand ( FasL ) , Fas , and caspase 8 , and weak positivity of anti apoptotic FLIP , these proteins being mainly localized in the cytotrophoblast compartment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RESULTS : Compared with APAP treated control mice , depletion of both NK and NKT cells by anti NK1 . 1 significantly protected mice from APAP induced liver injury , as evidenced by decreased serum ALT level , improved survival of mice , decreased hepatic necrosis , inhibition of messenger RNA ( mRNA ) expression for interferon gamma ( IFN gamma ) , Fas ligand ( FasL ) , and chemokines including KC ( Keratinocyte derived chemokine ) ; MIP 1 alpha ( macrophage inflammatory protein 1 alpha ) ; MCP 1 ( monocyte chemoattractant protein 1 ) ; IP 10 ( interferon inducible protein ) ; Mig ( monokine induced by IFN gamma ) and decreased neutrophil accumulation in the liver . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
An up regulated expression of Bcl 2 and Bcl 10 ( L ) proteins was observed in ECSC in comparison with ESCwE and NESC , whereas the levels of Bax , Bad , Fas and Fas ligand proteins in ECSC were similar to those in ESCwE and NESC . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cytoplasmic microvesicular form of Fas ligand in human early placenta : switching the tissue immune privilege hypothesis from cellular to vesicular level . ^^^ Fas ligand ( FasL ) expression in trophoblast has been implied as one of the mechanisms of fetal tolerance . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
As little is known about the mechanisms that regulate expression of Fas ligand and the subsequent release of FasL in epithelial ovarian cancer cells ( EOC ) , we investigated the effects of lysophosphatidic acid ( LPA ) on FasL expression and associated signaling pathways . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression in metastatic renal cell carcinoma during interleukin 2 based immunotherapy : no in vivo effect of Fas ligand tumor counterattack . ^^^ PURPOSE : It has been hypothesized that tumor cells expressing Fas ligand ( FasL ) might be able to counterattack and neutralize tumor infiltrating lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Resistance to receptor mediated cell death , such as the Fas / Fas ligand pathway , is one mechanism commonly exploited by metastatic cell populations . ^^^ We conclude that the increase of Fas on the surface of the LM 7 osteosarcoma cells increased their sensitivity to Fas induced cell death in the microenvironment of the lung , where Fas ligand is constitutively expressed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand is required for resolution of granulomatous experimental autoimmune thyroiditis . ^^^ We previously suggested that CD 8 ( + ) T cells promoted resolution of granulomatous experimental autoimmune thyroiditis ( G EAT ) at least in part through regulation of Fas ligand ( FasL ) expression on thyroid epithelial cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In order to explore a new special and effective way to prevent graft versus host disease ( GVHD ) after allogenic bone marrow transplantation ( allo BMT ) , the stem cell antigen 1 ( Sca 1 ) + early hematopoietic cells ( EHC ) from BALB / c mouse ( H 2d ) were introduced with exogenous mouse Fas ligand ( mFasL ) cDNA gene by the retrovirus mediated gene transfer and expanded for one week , and then they were co cultured with the spleen mononuclear cells ( SMNC ) from BAC mouse ( H 2dxb ) as one way mixed lymphocyte reaction ( OWMLR ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Intrathyroidal CD4+ T lymphocytes express high levels of Fas and CD4+ CD8+ macrophages / dendritic cells express Fas ligand in autoimmune thyroid disease . ^^^ We examined both Fas and Fas ligand ( FasL ) expression in lymphocyte subsets and nonlymphoid mononuclear cells including monocytes , macrophages , and dendritic cells ( M / DCs ) in both peripheral blood and thyroid specimens from 11 patients with Graves ' disease and 1 with Hashimoto ' s disease by three color flow cytometry . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the absence of CD8+ T cells , perforin and Fas ligand ( FasL ) but not granzyme B mRNA were detected in rejecting grafts . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Flow cytometry showed that the Fas ligand protein was overexpressed in EA treated MCF 7 cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In separate experiments , isolated perforin / , Fas ligand ( FasL ) / , and interferon ( IFN ) gamma / CD 8 lymphocytes were transferred to nude mice followed by identical experimented protocol . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The infected cells underwent histochemically confirmed apoptosis without lymphocyte infiltration after expressing CD 30 , CD 30 ligand ( CD30L ) , tumor necrosis factor ( TNF ) alpha , TNF receptor 1 ( TNF R 1 ) , FAS , and FAS ligand ( FAS L ) with activation of caspases 3 and 8 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Conversely , LXR and RXR agonists inhibited expression of proapoptotic regulators and effectors , including caspases 1 , 4 / 11 , 7 , and 12 ; Fas ligand ; and Dnase1l3 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand ( FasL ) , an AP 1 transcriptional target , increased during accelerated cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : Paraffin embedded sections of 19 radicular cysts ( RCs ) , and five residual radicular cysts ( RRCs ) and control specimens of normal gingivae excised from seven cadavers were prepared and examined immunohistochemically with the use of monoclonal antibodies or polyclonal antisera against single stranded DNA ( ssDNA ) , p 53 , Bax , Bcl 2 , caspase 3 , Fas , Fas ligand ( Fas L ) , and Ki 67 antigen . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
JAK mediated signaling inhibits Fas ligand induced apoptosis independent of de novo protein synthesis . ^^^ The studies described in this report examined the effects of exposure to the cytokine IFN alpha ( IFN alpha 2a ) on sensitivity of the human cell lines H 9 and SKW6 . 4 to Fas ligand ( FasL ) induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVE : To construct the Fas ligand ( FasL ) and inducible nitric oxide synthase ( iNOS ) coexpressed PCA 13 plasmid used for packing of adenovirus , so as to observe the immunoprotective effect of FasL on the adenovirus vector . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
An enhancement in Fas / APO 1 and its two form ligands , membrane bound Fas ligand ( mFasL ) and soluble Fas ligand ( sFasL ) , might be responsible for the apoptotic effect induced by prodelphinidin B 2 3 ' O gallate . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
PURPOSE : Fas ligand ( FasL ) and TNF related apoptosis inducing ligand ( TRAIL ) / Apo2L are members of the TNFalpha family that can trigger apoptosis in susceptible cells via respective death receptors ( DRs ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recipients were wild type mice treated with alpha NK cell antibodies or knockout strain mice lacking expression of CD 8 , perforin , Fas ligand , or 1 of the following cytokines : tumor necrosis factor alpha , transforming growth factor beta , interferon gamma , interleukin 4 , or interleukin 10 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis induced by penta acetyl geniposide in C 6 glioma cells is associated with JNK activation and Fas ligand induction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Similar results were obtained when Fas ligand or an agonistic Fas antibody initiated the Fas apoptosis pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Production of IFN gamma ; up regulation of CD 69 , CD40L , CD 95 ( Fas ) , and CD95L ( Fas ligand ) ; and induction of apoptosis were also affected by the lack of CD 28 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RECENT FINDINGS : The genetic basis of autoimmune lymphoproliferative syndrome has continued to expand with the recently identified defects in caspase 8 and caspase 10 along with the more frequent defect in Fas and unusual Fas ligand deficiency . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Calcineurin / NFAT induced up regulation of the Fas ligand / Fas death pathway is involved in methamphetamine induced neuronal apoptosis . ^^^ Because pathways linked to these factors are involved in the up regulation of Fas ligand ( FasL ) , FasL mRNA was quantified and found to be increased . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand in cyst fluids , serum and tumors of patients with benign and ( borderline ) malignant ovarian tumors . ^^^ Fas is a cell membrane receptor which , after engagement with Fas ligand ( FasL ) , triggers apoptotic death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
High levels of soluble Fas ligand have been implicated in development of chronic neutropenia . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We examined the effects of temperature on soluble Fas ligand induced apoptosis in freshly isolated mouse hepatocytes . ^^^ In contrast , the activation of initiator caspase 8 and cleavage of Bid were not affected after Fas ligand stimulation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Our data were as follows : ( a ) CRH induced rapid phosphorylation of conventional PKCalpha and PKCbeta , accompanied by parallel increase of their concentration within nucleus . ( b ) CRH suppressed the phosphorylation of novel PKCdelta and PKCtheta ; , which remained in the cytosol . ( c ) CRH induced transient phosphorylation of atypical PKClambda and had no effect on PKCmu . ( d ) The effect of CRH on each PKC isoenzyme was blocked by a CRHR 1 antagonist . ( e ) Blockade of conventional PKC phosphorylation inhibited CRH induced calcium ion mobilization from intracellular stores as well as the CRH induced apoptosis and Fas ligand production . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Therefore , we examined a role of Fas expression on antitumor effect of DOX using a syngeneic tumor model of Lewis lung carcinoma ( 3LL ) cells in C57BL / 6 gld mice that lack functional Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The immune response in the infected liver involves the interaction of cytotoxic T cells ( CTL ) with the hepatocytes through the interaction of FAS ligand on the CTL and FAS on the hepatocyte . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A systematic study was undertaken to characterize the role of APO 2 ligand / tumor necrosis factor related apoptosis inducing ligand ( APO2L / TRAIL ) and Fas ligand ( FasL ) together with the expression of several anti or proapoptotic proteins in the down regulation of normal human T cell responses . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
An increase in both Fas expression and Fas ligand ( FasL ) production was also observed in CD 57 ( + ) T cells , whereas the expression of survivin was suppressed in CD 57 ( + ) T cells compared to that of regular alphabeta T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , no significant correlation between Fas ligand ( Fas L ) expression and ACK 2 was found . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Preformed membrane bound Fas ligand ( FasL ) as well as downstream signaling molecules , including Fas associated death domain containing protein , procaspase 8 , procaspase 10 , c Jun amino terminal kinase , and Bid , were also translocated into lipid rafts , connecting death receptor extrinsic and mitochondrial intrinsic apoptotic pathways . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand gene silencing in basal cell carcinoma tissue with small interfering RNA . ^^^ Cells of BCC strongly express Fas ligand ( FasL ) , a member of the tumor necrosis family , which induces apoptosis in Fas receptor expressing cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Previously , we have developed a complex adenovirus ( Ad ) vector with tetracycline regulated expression of a Fas ligand ( FasL ) green fluorescent protein ( GFP ) fusion protein . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Lysophosphatidic acid stimulates fas ligand microvesicle release from ovarian cancer cells . ^^^ Previous reports support that lysophosphatidic acid ( LPA ) upregulates Fas ligand ( FasL ) cell surface presentation on the ovarian cancer cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The relative level of Fas ligand mRNA was increased after TCDD exposure , as well as Fas and Fas ligand protein levels detected by Western blotting and immunocytochemistry . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A cell permeant peptide derived from this sequence displaces cytochrome c from IP3R and abrogates cell death induced by staurosporine treatment of HeLa cells and Fas ligand stimulation of Jurkat cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
No significant modifications on Fas , the membrane form of Fas ( mFas ) and Fas ligand ( FasL ) expression , and on cytokine production were observed at BM level after the addition of PIs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Significance of Fas and Fas ligand in tuberculous lymphadenitis . ^^^ The Fas / Fas ligand ( FasL ) system plays an important role in regulation of apoptosis and the immune response , and is exploited by mycobacteria to evade the immune response . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The 844C / T polymorphism in the Fas ligand promoter associates with Taiwanese SLE . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Administration of the dual APL to mice concomitant with the immunization with either of the myasthenogenic peptides resulted also in the up regulation of c Jun NH 2 terminal kinase activity and of Fas signaling pathway molecules as determined by measuring Fas , Fas ligand , and caspase 8 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Bioactive IL 18 induces Interferon ( IFN ) gamma production , Fas Ligand ( FasL ) expression , and inhibits angiogenesis , raising the issue of anti tumor effects of a tumor derived cytokine and motivating a more detailed analysis of IL 18 production in pancreatic carcinoma cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
An essential role for IFN alpha in the overexpression of Fas ligand on MRL / lpr lymphocytes and on their spontaneous Fas mediated cytotoxic potential . ^^^ Lymphocytes from aged autoimmune MRL / lpr mice overexpress Fas ligand ( FasL ) , and are cytotoxic against Fas+ target cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The results showed that the expressions of Fas , Fas ligand ( FasL ) , Bcl 2 , and Bax were co localized predominantly in the epithelial cells of the endometrium . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Fas ligand expressions in peripheral blood mononuclear cells of patients with myelodysplastic syndromes . ^^^ Increased expressions of Fas and Fas ligand ( Fas L ) in bone marrow cells of myelodysplastic syndromes ( MDS ) have been reported , and large number of these `` cell death signals ' ' might explain molecular basis for exacerbation of apoptosis in marrow cells of these syndromes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the present study , we further investigated whether BCL 2 transfer into transplanted liver cells rendered them resistant to Fas ligand induced apoptosis , and protected rats from acute liver failure . ^^^ Forty eight hours later , cells challenged with recombinant Fas ligand ( rhsFasL ) were assayed for apoptosis using TUNEL staining and caspase 3 activity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Our results showed that 7 breast tumors have lost the expression of Fas and 11 tumors were positive for the Fas ligand expression , important arguments for the mechanisms of immune escape and tolerance induction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
There are two pathways of caspase 3 and caspase 7 mediated apoptosis : ( 1 ) the `` extrinsic ' ' pathway involving the death receptor Fas , Fas ligand ( FasL ) , and caspase 8 and ( 2 ) the `` mitochondrial ' ' or `` intrinsic ' ' pathway involving Bcl 2 proteins , caspase 2 , cytochrome c release , and caspase 9 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Coronary artery and orifice development is associated with proper timing of epicardial outgrowth and correlated Fas ligand associated apoptosis patterns . ^^^ Examination of double stainings of quail chicken chimeras revealed that EPDCs produce Fas ligand as an apoptotic inductor at sites of coronary ingrowth . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , transcripts up regulated during effector T ( H ) 1 T cell activation , most significantly the transcription factor T bet , the effector receptor Fas ligand and the costimulation molecule CD 152 clearly ( p = 0 . 001 ) distinguished the patient categories . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes . ^^^ Objective : In patients with oral squamous cell carcinoma , a high proportion of T cells in the tumor undergo apoptosis , which correlates with Fas ligand ( FasL ) expression on tumor cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We found that Bax and Bak translocated to mitochondria apparently , whereas Fas ligand ( FasL ) was unchanged after a treatment with luteolin for 3 h . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Effector memory T cells expressing Fas ( Apo 1 / CD95 ) are switched to an apoptotic program by cross linking with Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Dysregulations in the tumor necrosis factor alpha ( TNF alpha ) pathway , CD 95 system ( Fas ligand , CD95L ; Fas receptor , CD95R ) and calcium homeostasis in the epidermis are involved in this apoptotic process . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of Fas and Fas ligand was analyzed by labeling with specific antibodies followed by flowcytometry . ^^^ There was no change in the expression of Fas and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis related factors ( Fas receptor , Fas ligand , FADD ) in early tooth development of the field vole ( Microtus agrestis ) . ^^^ Fas ligand binding followed by Fas receptor oligomerisation leads to formation of a death inducing signal complex starting with recruitment of the Fas adapter protein ( FADD ) . ^^^ Frontal sections of the field vole at stage 13 . 5 15 . 5 of embryonic development were exploited to investigate and correlate location of Fas , Fas ligand , FADD molecules and apoptosis in developing first molars by immunohistochemistry . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Detection of Fas ligand in the bovine oviduct . ^^^ Presence of a Fas Fas ligand ( FasL ) system defines the immune privileged status of certain tissues such as placenta . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
IFN gamma or LPS stimulation enhanced intracellular but not cellular surface TRAIL , and neither intracellular nor cellular surface tumor necrosing factor alpha and Fas Ligand as analyzed by flow cytometry . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The engagement of NCR induced up regulation of Fas ligand ( FasL ) mRNA , FasL protein synthesis , and release . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The AECs expressed message for TNFalpha , Fas ligand ( FasL ) , TRAIL ( tumor necrosis factor related apoptosis inducing ligand ) , TGFbeta , and macrophage migration inhibitory factor ( MIF ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This study was designed to evaluate the interaction of ischaemic / reperfusion and reperfusion therapy coadministered with high dose GIK treatment on soluble Fas / APO 1 ( sFas ) and Fas ligand ( sFasL ) plasma concentration in patients with AMI . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Identical changes in Bax expression , but not Fas ligand expression , occur in structural luteolysis in gonadotropin releasing hormone agonist and prolactin treated superovulated rats . ^^^ In this study , we investigated whether GnRHa caused apoptosis in mature corpus luteum of superovulated rats and also examined the expression of apoptosis related molecules ( Fas , Fas ligand ( FasL ) , Bcl 2 , Bax ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In herniated lumbar disc tissue , increased apoptosis and a high expression of Fas and Fas ligand and caspase 3 activity have already been reported , suggesting a pivotal role of apoptotic mechanisms in intervertebral disc degeneration . ^^^ Expression of Fas and Fas ligand was analyzed by immunohistochemistry and reverse transcription polymerase chain reaction analysis . ^^^ A strong expression of Fas and Fas ligand could be detected in all samples . ^^^ The simultaneous increase of Fas and Fas ligand expression in areas with increased cell death point to an activation of the apoptotic process via the Fas / Fas L system . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
An enhancement in Fas / APO 1 and the two forms of Fas ligand ( FasL ) , membrane bound FasL and soluble FasL , might be responsible for the apoptotic effect induced by casuarinin . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cryptococcus neoformans capsular glucuronoxylomannan induces expression of fas ligand in macrophages . ^^^ The results reported here show that 1 ) soluble purified GXM induces a prompt , long lasting , and potent up regulation of Fas ligand ( FasL ) on macrophages , 2 ) the up regulation of FasL is related to induced synthesis and increased mobilization to the cellular surface , 3 ) this effect is largely mediated by interaction between GXM and TLR 4 , 4 ) FasL up regulation occurs exclusively in GXM loaded macrophages , 5 ) macrophages that show up regulation of FasL induce apoptosis of activated T cells expressing Fas and Jurkat cells that constitutively express Fas , and 6 ) anti Fas Abs rescue T cells from apoptosis induced by GXM . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We found that intraduodenal reovirus 1 / L inoculation of mice induced the expression of both GCT and CD11c on PP lymphocytes ( PPL ) , intraepithelial lymphocytes ( IEL ) , and lamina propria lymphocytes ( LPL ) , and these activated cells expressed Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Clinically , the Fas and Fas ligand system plays a central role in the development of hepatocyte apoptosis , a process contributing to a broad spectrum of liver diseases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We found that the interferon gamma ( IFN gamma ) and / or Fas ligand expressing cells in patient BM mononuclear cells and long term BM culture stroma cells were the CD 3 ( + ) T lymphocytes but not the CD 14 ( + ) monocytes / macrophages . ^^^ We conclude that CIN patients have increased number of activated T lymphocytes in the BM , probably in the setting of a localized polyclonal immune reaction and that these cells confer an inhibitory effect on myelopoiesis through myelosuppressive cytokines including Fas ligand and IFN gamma . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Considering Fas ligand as a target for therapy . ^^^ About a decade ago , the death factor Fas ligand ( FasL ) was identified as the natural trigger of Fas / CD95 dependent apoptosis and as an inducer of Fas dependent activation induced cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
At the cellular level , p 13 ( 2 ) has been found to interfere with cell proliferation and transformation and to promote apoptosis induced by ceramide and Fas ligand . ^^^ Assays carried out in T cells ( the major targets of HTLV 1 infection in vivo ) demonstrate that p 13 ( 2 ) mediated sensitization to Fas ligand induced apoptosis can be blocked by an inhibitor of Ras farnesylation , thus implicating Ras signaling as a downstream target of p 13 ( 2 ) function . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interestingly , the DOX induced up regulation in Fas ( CD95 / APO 1 ) and Fas ligand expression could be blocked by Ang 1 , indicating a pivotal role of Ang 1 in DOX induced Fas and Fas ligand expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Induction of cell death in rat small intestine by ischemia reperfusion : differential roles of Fas / Fas ligand and Bcl 2 / Bax systems depending upon cell types . ^^^ We investigated the appearance of apoptosis at various time points ( 0 24 h ) of reperfusion after 1 h ischemia and the expression of various apoptosis related proteins , such as Bcl 2 , Bax , Fas , Fas ligand ( FasL ) , activated caspase 3 , and cytochrome c , immunohistochemically in rat small intestine . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Up regulation of Fas ligand ( FasL ) in the central nervous system : a mechanism of immune evasion by rabies virus . ^^^ We found that the early production of Fas ligand ( FasL ) mRNAs was up regulated only in fatal rabies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In some models , tumors are rejected in the absence of lytic mechanisms ( e . g . perforin or Fas ligand ) , and in others CTLs kill tumor stromal cells that cross present antigen . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A variety of human cancer cells are resistant to Fas ligand and anti Fas antibody induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
An enhancement in Fas / APO 1 and its two forms of ligands , membrane bound Fas ligand ( mFasL ) and soluble Fas ligand ( sFasL ) , might be responsible for the apoptotic effect induced by casuarinin . ^^^ Our study reports here for the first time that the induction of p21 / WAF1 and the activity of Fas / Fas ligand apoptotic system may participate in the antiproliferative activity of casuarinin in MCF 7 cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Stimulation of microglial metabotropic glutamate receptor mGlu 2 triggers tumor necrosis factor alpha induced neurotoxicity in concert with microglial derived Fas ligand . ^^^ The neurotoxicity of TNFalpha derived from mGlu 2 stimulated microglia was potentiated by microglial derived Fas ligand ( FasL ) , the death receptor ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In bone metabolism , it has been shown that numerous TNF family members including receptor activator of nuclear factor kappaB ligand ( RANKL ) , TNF alpha , Fas ligand ( FasL ) and TNF related apoptosis inducing ligand ( TRAIL ) play pivotal roles in the differentiation , function , survival and / or apoptosis of osteoclasts , the principal bone resorbing cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Involvement of the fas ligand and fas system in apoptosis induction of mouse uterine natural killer cells . ^^^ Therefore , the present study was carried out to define the involvement of Fas ligand ( FasL ) and Fas in apoptosis induction of uNK cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
MX 3350 1 increased the levels of Fas ligand , Fas , and Fas associated death domain , and enhanced activation of procaspase 8 and cleavage of its substrate Bid . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In general , WW 85 had no direct action on expression of the proapoptotic gene , Fas ligand ; however , WW 85 given alone or with cyclosporine enhanced expression of antiapoptotic genes Bcl 2 and Bcl xL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
FAS receptor ( FAS , CD 95 ) and FAS ligand ( FAS L , CD 95 L ) are complementary members of a particular apoptotic pathway that plays a major role in immune regulation . ^^^ FAS receptor ( FAS , CD 95 ) and FAS ligand ( FAS L , CD 95 L ) are complementary members of a particular apoptotic pathway that plays a major role in immune regulation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
I . ) , Fas and Fas ligand were also immunohistochemically evaluated . ^^^ TAC 101 did not affect the expression of Fas ligand , but obviously increased the expression of Fas in the metastatic tumors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In Fas / APO 1 positive Hep G 2 cells , EAC increased the expression level of Fas / APO 1 and its two forms of ligands , membrane bound Fas ligand ( mFasL ) and soluble Fas ligand ( sFasL ) , in a p 53 indenpendent manner . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Doxorubicin activates nuclear factor of activated T lymphocytes and Fas ligand transcription : role of mitochondrial reactive oxygen species and calcium . ^^^ Pre treatment of cells with an intracellular calcium chelator abrogated DOX induced nuclear NFAT translocation , Fas L ( Fas ligand ) expression and caspase activation , as did pre treatment of cells with a mitochondria targeted antioxidant , Mito Q ( a mitochondria targeted antioxidant consisting of a mixture of mitoquinol and mitoquinone ) , or with adenoviral over expressed antioxidant enzymes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , we studied expressions of Fas ligand and perforin and interferon gamma ( IFN gamma ) secretion in HLA A 2 HCV ( core _ 35 44 ) tetramer positive T cells generated with lipopeptide amino acid 20 44 ( LP 20 44 ) . ^^^ Detailed analysis of HLA A 2 HCV ( core _ 35 44 ) tetramer positive T cells generated with LP 20 44 revealed that in vitro immunization resulted in T cells that secreted IFN gamma after antigen specific restimulation and that upregulated expression of Fas ligand but not of perforin . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Fas Ligand pathway is impaired in patients with type 2 diabetes . ^^^ OBJECTIVES : In type 2 diabetic patients with no cardiac history or symptoms , 1 ) to evaluate whether the soluble forms of Fas ( sFas ) and Fas ligand ( sFasL ) , involved in apoptosis , may be markers of silent coronary disease or related to hypertension or microangiopathic complications ; 2 ) to examine the effect of short term glycemic control on sFas and sFasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Serum soluble Fas ligand ( sFasL ) concentrations were measured by an ELISA method at baseline and after treatment in both groups , as well as in a group of healthy subjects . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Augmentation of Fas ligand induced apoptosis by MUC 1 mucin . ^^^ In this study , we determined whether MUC 1 affects Fas ligand ( FasL ) induced apoptosis using MUC 1 expressing ( MUC 1 ( + ) ) and MUC 1 ( ) cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TNF related apoptosis inducing ligand ( TRAIL ) , as well as Fas ligand , plays a pivotal role in lymphocyte cytotoxicity and the maintenance of immunological homeostasis in various tissues , but its physiological role in immune evasion of cancer cells remains unknown . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression by maternal decidual cells is negatively correlated with the abundance of leukocytes present at the maternal fetal interface . ^^^ In the present studies , we examined Fas ligand ( FasL ) / Fas expression at the maternal fetal interface in human placental tissues of early pregnancy by immunohistochemistry . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( CD 178 ) cytoplasmic tail is a positive regulator of Fas ligand mediated cytotoxicity . ^^^ The cytotoxic function of CD 178 ( Fas ligand ( FasL ) ) is critical to the maintenance of peripheral tolerance and immune mediated tissue pathology . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
DcR3 / TR6 , a secreted protein belonging to the TNF receptor superfamily , interacts with lymphotoxin like , exhibits inducible expression , and competes with herpes simplex virus glycoprotein D for herpes virus entrance mediator ( LIGHT ) , Fas ligand ( FasL ) , and TL1A , all members of the TNF superfamily . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Vaccination of apoptotic Fas ligand expressing tumors decreased antitumor responses by enhanced production of immunosuppressive cytokines . ^^^ Expression of Fas ligand ( FasL ) in tumors produced antitumor effects by generating both inflammation and T cell mediated immunity , although the Fas / FasL interaction induces an apoptotic process of Fas positive activated T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : Exactly what role does tumor derived Fas ligand ( FasL ) play in cancer : maintaining the immune privilege site or inducing a pro inflammatory effect . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Resistance to activation induced cell death and bystander cytotoxicity via the Fas / Fas ligand pathway are implicated in the pathogenesis of cutaneous T cell lymphomas . ^^^ By engaging Fas , Fas ligand ( FasL ) on activated T lymphocytes induces activation induced cell death ( AICD ) , and also triggers apoptosis of target cells during immune downregulation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although mediators such as steroids , tumor necrosis factor , nitric oxide , C5a , and Fas ligand ( FasL ) appear to contribute to the apoptotic changes , their effects are tissue and cell population selective . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
IL 15 converts human intestinal intraepithelial lymphocytes to CD 94 producers of IFN gamma and IL 10 , the latter promoting Fas ligand mediated cytotoxicity . ^^^ Intestinal intraepithelial lymphocytes ( IELs ) , T cell receptor alphabeta ( + ) CD 8 ( + ) T cells located between epithelial cells , are thought to contribute to Fas ligand ( FL ) mediated epithelial cell death in coeliac disease , a condition characterized by excess interleukin 15 ( IL 15 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the present study , we serially examined the gene expression of perforin , granzyme B and Fas ligand ( FasL ) in peripheral blood lymphocytes ( PBLs ) of renal allograft recipients to assess the potential of their expression as a marker of acute rejection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas and Fas ligand provide new information on metastasis and response to chemotherapy in SCLC patients . ^^^ BACKGROUND : The Fas / Fas ligand ( FasL ) system is a major regulator of apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of apoptosis related genes such as BCL 2 , BAX , Fas receptor ( FAS ) , and Fas ligand ( FASLG ) was quantified using real time polymerase chain reaction ( PCR ) analysis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Studies addressing the mechanism of action of Ad mda 7 induced tumor cell apoptosis revealed early activation of the transcription factors c Jun and activating transcription factor 2 , which in turn stimulated the transcription of an immediate downstream target , the death inducer Fas ligand ( FasL ) , and its cognate receptor Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Corneal graft rejection occurs despite Fas ligand expression and apoptosis of infiltrating cells . ^^^ BACKGROUND / AIMS : Constitutive expression of Fas ligand ( CD95L ) protects the eye against cell mediated immune responses by inducing apoptosis in infiltrating Fas bearing T cells . ^^^ This study was designed to examine Fas ligand expression on acutely rejecting rat corneal grafts and to investigate the kinetics of induction of apoptosis in infiltrating leucocytes . ^^^ Fas ligand expression and the phenotype of infiltrating leucocytes were examined by immunohistochemistry . ^^^ RESULTS : Fas ligand was expressed on corneal endothelial and epithelial cells during acute corneal graft rejection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression following normothermic liver ischemia reperfusion . ^^^ BACKGROUND : The aim of this study was to evaluate the role of the pro apoptotic molecule Fas Ligand ( FasL ) in 120 min normothermic ischemia reperfusion ( 1 R ) induced apoptosis in rat liver treated or not with Z Asp cmk caspase inhibitor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
PURPOSE : Substantial evidence indicates that supraoligomerization of the death receptors for Fas ligand and tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) is necessary for efficient activation of the apoptotic pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We detected the presence of human papilloma virus ( HPV ) , cytomegalovirus ( CMV ) , Epstein Barr virus ( EBV ) , herpes simplex virus ( HSV ) 1 , HSV 2 and human herpesvirus ( HHV ) 8 DNA in oral tissues by polymerase chain reaction ( PCR ) and Southern hybridization techniques , and quantified the serum levels of cytokines including interleukin ( IL ) 2 , IL 4 , granulocyte macrophage colony stimulating factor ( GM CSF ) , soluble Fas ( sFas ) and the Fas ligand ( FasL ) by enzyme linked immunosorbent assay ( ELISA ) for 67 recurrent aphthous ulcer ( RAU ) patients and 72 normal individuals . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast to treatment with Fas ligand or gliotoxin , AEA mediated death was caspase independent and showed typical features of necrosis such as rapid adenosine triphosphate depletion and propidium iodide uptake . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In silico docking studies demonstrated the specific interaction of FRAP 4 with the main Fas ligand ( FasL ) binding domain in the Fas molecule . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) and its receptor ( TRAILR ) mRNA were analyzed by Northern blot and Western blot was used to detect the expression of Fas and Fas ligand ( FasL ) protein . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Transfection of apoptosis related gene Fas ligand in human hepatocellular carcinoma cells and its significance in apoptosis . ^^^ AIM : To evaluate the expression of apoptosis related gene Fas ligand ( FasL ) in human hepatocellular carcinoma ( HCC ) cells HepG 2 and its significance in apoptosis . ^^^ METHODS : Levels of soluble Fas ligand ( sFasL ) in a group of patients with hepatitis B virus ( HBV ) induced chronic hepatitis , HBV positive liver cirrhosis and HCC were evaluated . ^^^ CONCLUSION : Fas ligand is an apoptotic pathway of HCC cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVE : Binding of Fas ligand or agonistic anti Fas antibody to the death receptor Fas can activate a caspase cascade resulting in apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Another member of the TNF family Fas ligand ( FasL ) is also known to induce apoptosis in a variety of tumor cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interaction with its counterpart the Fas ligand induces the apoptosis of Fas bearing cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Diacylglycerol kinase alpha regulates the secretion of lethal exosomes bearing Fas ligand during activation induced cell death of T lymphocytes . ^^^ Fas ligand ( FasL ) mediates both apoptotic and inflammatory responses in the immune system . ^^^ FasL function critically depends on the different forms of FasL ; soluble Fas ligand lacking the transmembrane and cytoplasmic domains is a poor mediator of apoptosis , whereas full length , membrane associated FasL ( mFasL ) is pro apoptotic . mFasL can be released from T lymphocytes , via the secretion of mFasL bearing exosomes . mFasL in exosomes retains its activity in triggering Fas dependent apoptosis , providing an alternative mechanism of cell death that does not necessarily imply cell to cell contact . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We examined the plasma levels of soluble Fas ( sFas ) or Fas ligand ( sFas L ) , tumor necrosis factor alpha ( TNF alpha ) , and interleukin 6 ( IL 6 ) in patients with idiopathic nonobstructive ( HNCM ) and dilated phase ( DHCM ) hypertrophic cardiomyopathy . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
ISL treatment was found to result in the upregulation of p 53 , p21 / WAF1 , Fas / APO 1 receptor , Fas ligand , Bax and NOXA , but not in Bad . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Moreover , injection of dendritic cells ( DC ) genetically modified to express IL 4 or Fas ligand was able to reverse established murine arthritis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These agents lead to hepatocellular injury and necrosis , inflammatory infiltration and fibrosis ( steatohepatitis ) through induction of Fas ligand and cytokines ( tumor necrosis factor alpha , transforming growth factor beta , interleukin 8 ) , and lipid peroxidation and by products ( malondialdehyde and 4 hydroxynonenal ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These genes encode a host of proteins with divergent functions in a variety of cellular processes including apoptosis ( FAS , Fas ligand , PIN , HSP90beta , bcl 2 , bcl 10 ) , cell signal transduction ( Ras , RGS 1 , IRF 1 , STAT 3 ) , receptor mediated signaling transduction ( CD 71 , CD 69 , CD3delta ) , cell cycle and growth ( c myc , cytokines , kinase ) , transcriptional regulation ( EWS , CREB 2 ) , and chemotaxis ( beta chemokines , RANTES ) , supporting the general effects of HIV 1 infection on cells of different origin . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Decoy receptor 3 ( DcR 3 ) , a soluble receptor in the tumor necrosis factor ( TNF ) receptor family , is known to inhibit apoptosis mediated by pro apoptotic TNF family cytokines such as Fas ligand ( FasL ) , TL1A , and LIGHT . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased Fas ligand expression of CD4+ T cells by HCV core induces T cell dependent hepatic inflammation . ^^^ Phenotypic analysis of the liver infiltrating T cells revealed high expression levels of CD 44 and Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In conclusion , the significant increase in the cure rate after methylselenocysteine / CPT 11 could be related to increased drug delivery into both tumors ( CES 1 ) , reduced resistance to SN 38 ( ABCC 1 and DRG 1 ) in FaDu , and induced Fas ligand apoptosis ( TNFSF 6 ) in A 253 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand and bcl 2 in cervical carcinoma and their prognostic significance . ^^^ We performed immunohistochemical analysis of Fas ligand ( FasL ) and bcl 2 in invasive cervical cancer to determine the association with prognosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This level of CrmA expression provided some protection against Fas ligand ( FasL ) induced apoptosis and promoted accumulation of myeloid cells in the bone marrow , but it did not inhibit mitogen induced proliferation of B or T lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CEACAM 1 ( CD66a ) mediates delay of spontaneous and Fas ligand induced apoptosis in granulocytes . ^^^ DNA fragmentation assays and annexin 5 staining revealed that binding of CEACAM 1 specific antibodies , Fab fragments and soluble CEACAM 1 Fc constructs to cell surface expressed CEACAM 1 causes a delay of spontaneous and Fas ligand ( CD95L ) induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( CD 95 ) mediates apoptosis of many cell types , but the susceptibility of cells to killing by Fas ligand and anti Fas antibodies is highly variable . ^^^ Fas ( CD 95 ) mediates apoptosis of many cell types , but the susceptibility of cells to killing by Fas ligand and anti Fas antibodies is highly variable . ^^^ Jurkat T cells lacking CD 47 ( integrin associated protein ) are relatively resistant to Fas mediated death but are efficiently killed by Fas ligand or anti Fas IgM ( CH 11 ) upon expression of CD 47 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased vulnerability of pre existing atherosclerosis in ApoE deficient mice following adenovirus mediated Fas ligand gene transfer . ^^^ OBJECTIVE : The death receptor Fas and Fas ligand ( FasL ) are present in human advanced atherosclerotic plaques . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This effect is manifested in part through up regulation of the death receptor Fas ligand ( FasL ) by HIV 1 negative factor ( Nef ) , leading to bystander damage . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : Expressions of Fas ; Fas ligand ( FasL ) ; caspase 3 , 8 , 9 , 10 ; Ki 67 protein ; and TUNEL were examined in 4 week , 6 month and 12 month old rat NPs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Serum and follicular fluid levels of soluble Fas , soluble Fas ligand and apoptosis of luteinized granulosa cells in PCOS patients undergoing IVF . ^^^ The aim of the current study was to determine follicular fluid , and serum levels of soluble Fas ( sFas ) and soluble Fas ligand ( sFasL ) in PCOS patients undergoing IVF / ICSI cycles ; also to investigate the effects of metformin on these factors and on apoptosis of luteinized granulosa cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The induction of apoptosis in naive lymphocytes by H 2K deficient melanoma cells does not involve the Fas ligand ( Fas L ) / FAS signaling module , as demonstrated by employing lymphocytes derived from Fas L ( gld ) or Fas ( lpr ) deficient mice in co culture experiments . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Inflammatory arthritis requires Foxo3a to prevent Fas ligand induced neutrophil apoptosis . ^^^ This reflects a need for Foxo3a to maintain neutrophil vitality during inflammation by suppressing Fas ligand ; because Foxo3a can bind and suppress the Fasl promoter , Foxo3a deficient neutrophils upregulate Fas ligand and undergo apoptosis in response to TNF alpha and IL 1 , and Fas ligand blockade renders Foxo3a deficient mice susceptible to both arthritis and peritonitis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Because human colorectal cancer cells are hypothesized to escape immune recognition by expressing proapoptotic molecules , we investigated whether microvesicles bearing Fas ligand and tumor necrosis factor related apoptosis inducing ligand and inducing apoptosis of activated T cells are secreted by colorectal cancer cells both in vitro and in affected patients . ^^^ METHODS : Fas ligand and tumor necrosis factor related apoptosis inducing ligand expression were analyzed in colorectal cancer cells and purified microvesicles by flow cytometry , Western blotting , and immunoelectron microscopy . ^^^ RESULTS : Colorectal cancer cells showed a granular pattern of tumor necrosis factor related apoptosis inducing ligand and Fas ligand expression , suggesting a secretory behavior . ^^^ Microvesicles induced Fas ligand mediated and tumor necrosis factor related apoptosis inducing ligand mediated apoptosis of activated CD8+ T cells generated from colorectal cancer patients . ^^^ Microvesicles with comparable phenotypes and functions were found in plasma from patients with advanced disease , whereas vesicular structures expressing Fas ligand and tumor necrosis factor related apoptosis inducing ligand were also detected in colorectal cancer specimens . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand , perforin and granzyme B transcripts were all elevated at 48 and 72 h post transplant . ^^^ Elevated cytotoxic effector molecule expression ( Fas ligand , perforin , granzyme B ) indicates T cell mediated graft destruction by cytotoxic and cytolytic mechanisms within 48 to 72 h after transplantation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Impaired lymphocyte function is mediated by apoptotic factors including receptor binding cancer antigen expressed on SiSo cells ( RCAS 1 ) , Fas ligand ( FasL ) , and tumor necrosis factor alpha ( TNF alpha ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although both interferon ( IFN ) gamma and Fas ligand ( FasL ) were detected in MLC SN by enzyme linked immunosorbent assay , the apoptosis inducing capacity could be fully abrogated by neutralization of IFN gamma , but not by neutralization of FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand in the uterus of the non pregnant mouse induces apoptosis of CD4+ T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand and Bcl 2 expressions remained unchanged . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activation induced cell death ( AICD ) in T lymphocytes depends on the expression of Fas ligand , which triggers the apoptotic process after binding to its receptor Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The authors previously showed that pLCs express Fas and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the effect of Astragalus injection ( AGI ) on serum apoptosis related factors such as soluble Fas ( sFas ) , soluble Fas ligand ( sFasL ) and tumor necrosis factor alpha ( TNF alpha ) in patients with chronic heart failure ( CHF ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Leukotrienes , interleukin 8 , and growth related oncogene , in combination with Fas ligand and interleukin 1 , mediated SPARC effects . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas associated death domain , and not Fas , Fas ligand , or caspase proteins , increased following cell treatment with camptothecin + CH 11 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although cisplatin treatment results in significant elevation in the expression of Fas ligand and intracellular p 21 levels , expression of Siva 1 has no additional benefit . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The GBM lines were characterized for their expression of CD 70 , Fas ligand ( FasL ) , and tumor necrosis factor alpha ( TNF alpha ) , and the possible participation of those molecules in T cell killing was assessed by doing GBM / T cell cocultures in the presence of anti CD 70 antibodies , Fas fusion proteins , or anti TNF alpha antibodies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression in colon cancer : a possible mechanism of tumor immune privilege . ^^^ AIM : To detect the expression of Fas ligand ( FasL ) in colon cancer tissues and cell lines and analyze the function of FasL expressing colon cancer cells in inducing Fas sensitive T lymphocyte apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CTLA 4 Fas ligand gene transfer mediated by adenovirus induce long time survival of murine cardiac allografts . ^^^ BACKGROUND : Fas ligand gene transfer to induce peripheral allograft tolerance in animal models has shown controversial results . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Action and mechanism of Fas and Fas ligand in immune escape of gallbladder carcinoma . ^^^ AIM : To study the role of Fas and Fas ligand ( FasL ) in biological behaviors of gallbladder carcinoma , and their correlated action and mechanism in tumor escape . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Treatment of mice with 2 , 3 , 7 , 8 tetrachlorodibenzo p dioxin leads to aryl hydrocarbon receptor dependent nuclear translocation of NF kappaB and expression of Fas ligand in thymic stromal cells and consequent apoptosis in T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The influence of effector T cells and Fas ligand on lupus associated B cells . ^^^ Likewise , anti chromatin autoantibody production is T cell dependent in Fas / Fas ligand ( FasL ) deficient ( lpr / lpr or gld / gld ) mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Transmigration across the Fas ligand deficient BALB / c LSECs failed to render CD 4 ( + ) T cells tolerant . ^^^ Thus , we demonstrate that Fas ligand expressed on naive LSECs can impart tolerogenic potential upon alloantigen recognition via the direct pathway . ^^^ In conclusion , LSECs are capable of regulating a polyclonal population of T cells with direct allospecificity , and the Fas / Fas ligand pathway is involved in such LSEC mediated T cell regulation . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Whether the epithelial apoptosis in HIVAN is mediated by NF kappaB activated Fas ligand expression was investigated here . ^^^ Podocyte cell lines that were derived from HIV 1 transgenic mice showed a similar upregulation of Fas receptor expression and de novo expression of Fas ligand by semiquantitative reverse transcription PCR and Western blotting . ^^^ Because constitutive NF kappaB activity has been demonstrated in HIVAN epithelia , evidence for transcriptional control of the Fas ligand expression by NF kappaB was sought . ^^^ With the use of cultured podocytes , expression of a Fas ligand promoter reporter plasmid was higher in HIVAN podocytes , indicating increased transcriptional activity . ^^^ In addition , chromatin immunoprecipitation assays were performed to demonstrate that p 65 containing ( RelA ) complexes bound the Fas ligand promoter and that suppression of activated NF kappaB with a peptide inhibitor could reduce the expression of Fas ligand mRNA in HIVAN podocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To assess the role of Fas signaling in OM , we probed for expression of Fas and Fas ligand ( FasL ) by polymerase chain reaction ( PCR ) during bacterial OM in the rat . ^^^ We saw evidence of increased expression of Fas and Fas ligand during bacterial OM . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Based on the emerging roles of Fas ligand killing and complement deposition in allograft rejection , we correlated the amount of tissue specific TUNEL positive apoptosis and deposition of complement ( C5b 9 ) with histopathologic changes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Presence of membrane and soluble forms of Fas ligand and of matrilysin ( MMP 7 ) activity in normal and abnormal human semen . ^^^ BACKGROUND : The aim of this study is to shed some light on the role of the Fas system in human semen , by investigating whether there is an association between the expression of the molecules regulating the Fas system [ membrane bound Fas ligand ( mFasL ) , soluble Fas ligand ( sFasL ) and matrilysin , the metalloprotease cleaving mFasL to sFasL ] and sperm parameters . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand but not complement is critical for control of experimental Staphylococcus aureus Endophthalmitis . ^^^ PURPOSE : To determine the role of complement and Fas Ligand ( FasL ) in the host defense against Staphylococcus aureus endophthalmitis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A prior study showed that ocular tumors expressing the membrane only form of Fas ligand ( FasL ) terminate immune privilege , induce vigorous inflammation , undergo rejection , and induce systemic protective immunity . ^^^ METHODS : Microvesicles expressing either no FasL or membrane only Fas ligand were coinjected with L5178Y R lymphoma cells into the anterior chambers ( AC ) of DBA / 2 mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Triggering the drug induced Fas receptor with an exogeneous soluble Fas ligand ( sFasL ) resulted in an increase in the extent of apoptotic cell death , indicating that the Fas signaling pathway remained functionally active . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , little is known about the mechanism of beta cell destruction in this diabetes subtype , and to obtain insights into the aetiology of the disease , we investigated residual endocrine cells and the expression of Fas and Fas ligand in fulminant type 1 diabetes . ^^^ In addition , the expression of Fas and Fas ligand was evaluated by immunohistochemistry . ^^^ No Fas expression in islets and Fas ligand expression in CD 3 ( + ) cells in the exocrine pancreas were found in the fulminant type 1 diabetic patients who underwent this evaluation . ^^^ In addition to the lack of Fas and Fas ligand expression , the results suggest that the mechanism of beta cell destruction in fulminant type 1 diabetes is different from that in autoimmune type 1 diabetes . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
AIM : To investigate the potential role of cytokines in promoting Fas ligand ( FasL ) expressing colon cancer cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activations of caspase 8 and 3 were detected from dying HAoSMCs . 7 Ketocholesterol inhibited translocation of the nuclear factor kappaB ( NF kappaB ) subunits of p 65 and p 50 from the cytosol into the nucleus , increase of NF kappaB activity , and expression of caspase 8 homolog Fas ligand interleukin 1 converting enzyme inhibitory protein by TNF alpha . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Protein kinase C zeta associates with death inducing signaling complex and regulates Fas ligand induced apoptosis . ^^^ Previous studies have shown that Protein kinase C ( PKC ) stimulation may interfere with Fas signaling pathway and Fas ligand ( FasL ) induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , receptors associated with activation / apoptotis ( CD11b , CD 64 , tumor necrosis factor receptor , and Fas ligand ) are up regulated , together with a loss of CD 16 expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Further studies were conducted to compare these changes to the localization and expression of the bcl 2 group of proteins bcl 10 , bax and mcl 1 , and Fas Fas ligand in the same cells . ^^^ Fas receptor could be detected by flow cytometry , whereas the most resistant cell line ( M38K ) lacked Fas ligand when assessed by RT PCR . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Resistance to apoptosis is a hallmark of cancer in which FAS / FAS ligand signaling plays an important role . ^^^ The present study examines the hypothesis that genetic polymorphisms in FAS and FAS ligand genes , alone or in combination , are associated with cervical carcinogenesis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Quantitative real time polymerase chain reaction ( TaqMan RTPCR ) was used to elucidate the effect of UVA and UVB irradiation on the expression of genes coding for TNF alpha , IL 1beta , IL 10 , FasL , matrilysin , TACE and furin in HaCaT cells over a 48 h period ( IL 1beta , interleukin 1beta ; FasL , Fas ligand ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
FAS ( CD 95 ) and FAS ligand ( FASL ; CD95L ) have been implicated in chemosensitivity through leading to apoptosis in response to DNA damaging drugs . ^^^ FAS / FAS ligand ratio : a marker of oxaliplatin based intrinsic and acquired resistance in advanced colorectal cancer . ^^^ FAS ( CD 95 ) and FAS ligand ( FASL ; CD95L ) have been implicated in chemosensitivity through leading to apoptosis in response to DNA damaging drugs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
MNs in mice lacking functional Fas receptor and Fas ligand were protected from apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
B cells from gld donors were not tolerogenic , initially suggesting a role for Fas ligand ( FasL ) in tolerance . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The FKHR activation was accompanied by an increase in DNA binding activity for FKHR responsive element on the Fas ligand promoter . ^^^ We also defined FKHR induced downstream targets such as Fas ligand and Bim in brain ischemia . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
One of the primary mechanisms is the Fas ( CD 95 ) / Fas ligand system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We found a decrease of Fas expression after irradiation , but no change in Fas ligand expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Clinical importance of circulating and cellular expression levels of Fas and Fas ligand in pediatric patients with lymphoproliferative malignancies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , Fas ligand expression and function was not affected by Thy 1 blockade . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , TNF alpha was clearly identified as an important mediator for hepatic injury in this model that increased Fas ligand expression on NKT cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand and TNF related apoptosis inducing ligand induction on infiltrating lymphocytes in bladder carcinoma by bacillus Calmette Gurin treatment . ^^^ METHODS : Immunofluorescence staining allowed the specific detection of Fas , Fas ligand ( FasL ) , and tumor necrosis factor ( TNF ) related apoptosis inducing ligand ( TRAIL ) expression on tumor cells and the respective leukocyte populations in biopsy samples from 6 patients . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of IL 1beta , extracellular signal regulated kinase ( ERK ) , p 38 MAPK , Akt / protein kinase B ( PKB ) , Fas ligand and caspase 3 were determined by Western blotting . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Effector cells derived from host CD 8 memory T cells mediate rapid resistance against minor histocompatibility antigen mismatched allogeneic marrow grafts without participation of perforin , Fas ligand , and the simultaneous inhibition of 3 tumor necrosis factor family effector pathways . ^^^ Although T cell mediated cytotoxicity has been assumed to play a role in the resistance against donor allogeneic hematopoietic stem and progenitor cell grafts , several studies have reported relatively unimpaired resistance by recipients who lack perforin , Fas ligand ( FasL ) , and other cytotoxic mediators . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Prognostic significance of Bax and Fas ligand in erionite and asbestos induced Turkish malignant pleural mesothelioma . ^^^ Expression of Bcl 2 , Bax , Fas and Fas Ligand , were assessed by immunohistochemistry . ^^^ The staining extension of Fas Ligand was 26 . 87 + / 31 . 87 % , 46 . 10 + / 37 . 30 % and 26 . 47 + / 23 . 23 % for erionite and asbestos induced MPM , and adenocarcinoma , respectively ( p = 0 . 123 ) . ^^^ Fas Ligand positive patients showed statistically better survival than Fas Ligand negative patients in all MPM group ( 15 months versus 12 months ) ( p = 0 . 05 ) . ^^^ However , Fas Ligand may be functionally intact to reduce tumor survival . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , the storage of granzyme B , but not granzyme A , Fas ligand , or perforin , was severely defective in serglycin deficient cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Meanwhile , immunoblotting analysis also showed that the co administration of esculetin and Taxol could increase the expression of Bax and the cytosolic release of cytochrome C and enhance the expression of Fas and Fas ligand while the activation of caspase 8 and caspase 3 was also increased . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Importantly , we also provide evidence that E2F1 sensitizes tumor as well as primary cells to apoptosis mediated by FAS ligand or tumor necrosis factor related apoptosis inducing ligand , and enhances the cytotoxic effect of T lymphocytes against tumor cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVE : This study was designed to evaluate reperfusion therapy , co administered with high dose glucose insulin potassium ( GIK ) treatment on serum soluble Fas / APO 1 ( sFas ) and Fas ligand ( sFasL ) concentration in Acute Myocardial Infarction ( AMI ) patients . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The aortic level of 8 ( OH ) dG and the expression of caspase 8 , caspase 9 and Fas ligand were also suppressed after ellagic acid supplement . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tumor exosomes expressing Fas ligand mediate CD8+ T cell apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We previously reported the characterization of a MHC class 2 ( low ) CD 4 CD103+ ( CD 4 ) subset of dendritic cells ( DC ) in rat spleen that exhibit a Ca2+ , Fas ligand , TRAIL and TNF alpha independent cytotoxic activity against specific targets in vitro . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This regimen prolonged survival of the animals and induced tumor specific CTLs that expressed TRAIL , which in concert with perforin and Fas ligand ( FasL ) was involved in the tumor specific CTL activity of these cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Carbohydrate structural characterization of fas ligand inhibitory protein . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Agonists of an ecdysone inducible mammalian expression system inhibit Fas Ligand and TRAIL induced apoptosis in the human colon carcinoma cell line RKO . ^^^ Inhibition of Fas ligand and TNF related apoptosis inducing ligand induced apoptosis by muristerone A occurs at the level of caspase 8 activation and is neutralized by phosphatidylinositol 3 kinase / Akt , protein kinase C and mitogen activated protein kinase inhibitors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Measures were mucosal apoptosis , proliferation , villous morphology , apoptotic , and proliferative mediators , such as Caspases 3 , 8 , Fas and Fas Ligand , Bcl 2 , and Bcl 10 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Similarly , immunoreactivity for the apoptotic signals Fas , Fas ligand , Bax , Bcl 10 , caspase 8 , caspase 9 and caspase 3 was absent from the NBM of AD and control brains . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Characterization of soluble FAS , FAS ligand and tumour necrosis factor alpha in patients with chronic HCV infection . ^^^ OBJECTIVES : The aims of this study were ( 1 ) to assess the susceptibility of the Fas antigen expressed on peripheral blood mononuclear cells to Fas ligand induced death in patients with chronic HCV infection and ( 2 ) to investigate the correlation between the plasma levels of soluble Fas ( sFas ) , soluble Fas ligand ( sFasL ) , tumour necrosis factor alpha ( TNF alpha ) , alanine amino transferase ( ALT ) , and HCV viral load . ^^^ STUDY DESIGN : The susceptibility of peripheral blood mononuclear cells from 17 subjects with chronic HCV infection to Fas ligand induced cell death was assessed using a water soluble tetrazolium assay . ^^^ CONCLUSIONS : PBMC in HCV infection exhibit decreased susceptibility to Fas ligand induced cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The death receptor Fas ( Apo1 / CD95 ) and Fas ligand ( FasL ) system is recognised as a major pathway for the induction of apoptosis in vivo , and antiapoptosis via its blockade plays a critical role in carcinogenesis and progression in several malignancies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Reverse transcription PCR analyses confirmed the regulation of a group of apoptosis related genes , including the up regulation of the decoy receptor that inhibits tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) action , TRAIL receptor 4 , and the down regulation of Fas , the receptor that mediates the action of Fas ligand . ^^^ Consistent with the regulation of the death receptors , pretreatment with 1 , 25 dihydroxyvitamin D 3 decreased apoptosis induced by TRAIL and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : Previous studies showed that the role of Fas ligand ( FasL ) is not consistent in the pathogenesis of autoimmune thyroiditis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The evaluation of soluble Fas and soluble Fas ligand levels of bronchoalveolar lavage fluid in lung cancer patients . ^^^ Fas Fas Ligand ( FasL ) is one of the major mediator system that activates programmed cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Turnover of neutrophils mediated by Fas ligand drives Leishmania major infection . ^^^ Apoptosis mediated by Fas ligand ( FasL ) initiates inflammation characterized by neutrophilic infiltration . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The role of Fas ligand as an effector molecule in corneal graft rejection . ^^^ Previous studies have shown that the expression of Fas ligand ( FasL ; CD95L ) by donor corneas is critical to their survival when placed on allogeneic recipients . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Plasmodium vivax malaria patients who presented with hepatic dysfunction had significantly higher mean serum concentrations of soluble Fas ligand , interleukin ( IL ) l , IL 4 , IL 6 , IL 10 , tumor necrosis factor alpha , and interferon gamma than those without hepatic dysfunction , suggesting the involvement of these cytokines in the development of hepatic dysfunction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
On the other hand , TLR 2 and Fas ligand expression on intrahepatic NK1 . 1 ( + ) T cells increased on day 1 after BDL in C57BL / 6 mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Serum levels of insulin like growth factor 1 , 2 , and binding protein 3 , transforming growth factor beta 1 , soluble fas ligand and superoxide dismutase activity in stomach cancer cases and their controls in the JACC Study . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here , we report that defects in the Fas / Fas ligand system unexpectedly render mice highly susceptible to neural degeneration in a model of Parkinson ' s disease . ^^^ Mice with generalized lymphoproliferative disease , which express a mutated Fas ligand , display an intermediate phenotype between that of lymphoproliferative and WT mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Retinoids are known to inhibit the proliferation of skin fibroblasts , collagen synthesis , modulate immune responses , and apoptosis by Fas ligand upregulation in skin fibroblasts . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The membrane receptor Fas ( Apo 1 / CD95 ) is an important initiator of programmed cell death induced by anti Fas antibody or Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activation of several cell death programs represented by Fas ligand , FADD ( Fas Associated Death Domain / Mort1 ) and the caspase cascade ( caspase 8 and 3 ) and survival programs represented by phosphorylated protein kinase B ( PKB / Akt ) , Bcl 2 associated death domain ( BAD ) , and cAMP responsive element binding protein ( CREB ) were examined using immunohistochemistry and Western blotting . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Serum and follicular fluid levels of soluble Fas and soluble Fas ligand in IVF cycles . ^^^ OBJECTIVE : To determine follicular fluid ( FF ) and serum levels of soluble Fas ( sFas ) and soluble Fas ligand ( sFasL ) in patients undergoing IVF cycles . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Treatment of several prostate cancer ( CaP ) cell lines ( PC 3 , CL 1 , and DU 145 ) with the nitric oxide ( NO ) donor DETA / NONOate upregulated Fas expression and sensitized the CaP cells to the Fas ligand CH 11 agonist monoclonal antibody induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas dependent apoptosis is carefully regulated by cooperative interactions with other TNF receptors , particularly CD 40 , that act to amplify autocrine and paracrine expression of Fas ligand and Fas mediated killing . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble Fas receptor and soluble Fas ligand in the serum of women with uterine tumors . ^^^ One of the best characterized systems is the Fas Fas ligand system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas , Fas ligand , p 53 , Bax and Bcl 2 expressions were analyzed by the respective monoclonal and polyclonal antibodies , using indirect immunofluorescence . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Polymorphism of Fas and Fas ligand in preterm premature rupture of membranes in singleton pregnancies . ^^^ We investigated the association between polymorphisms at position 670 in the Fas gene and position 124 in the Fas ligand gene demonstrated in neonatal oral mucosa cells and preterm premature rupture of membranes . ^^^ Buccal swabs were obtained from each neonate , and extracted deoxyribonucleic acid was analyzed by polymerase chain reaction based restriction fragment length polymorphism for an adenine ( A ) to guanine ( G ) substitution at position 670 in the Fas promoter gene and at position 124 in the Fas ligand gene . chi 2 and Fisher ' s exact tests were used for statistical analysis . ^^^ Similarly , the difference of frequencies of the Fas ligand 124 AG , AA , and GG genotypes among preterm premature rupture of membranes group and controls was observed but did not reach statistical significance . ^^^ Neither of the groups demonstrated homozygous GG genotype at position 124 of the Fas ligand gene . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This study aims to assess the relationship of Fas ligand ( Fas L ) to HCC . ^^^ Fas ligand expression in tissue was examined immunohistochemically using a rabbit purified polyclonal antibody . ^^^ Fas ligand cytoplasmic expression was more pronounced in HCC than in cirrhosis , and in cirrhosis more than in chronic hepatitis . ^^^ These results suggest that HCV and Fas ligand play a key role in hepatocarcinogenesis , consistent with the hypothesis that HCV induces overexpression of Fas ligand in the liver cells , resulting in escape from killing by the immune system cells , with subsequent uncontrolled growth of tissue and the development of malignancy . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NRVM were treated with H2O2 ( 0 . 5 mM ) for 2 4 h and thereafter exposed for 7 h to recombinant Fas ligand ( rFasL , 10 ng / ml ) plus an enhancing antibody ( 1 microg / ml ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Genetic polymorphisms of Fas ( CD 95 ) and Fas ligand ( CD 178 ) influence the rise in CD4+ T cell count after antiretroviral therapy in drug nave HIV positive patients . ^^^ Fas and Fas ligand ( FasL ) are the main genes that control cell death in the immune system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This review summarizes a current understanding of the Fas ( CD 95 ) Fas ligand ( CD 178 ) apoptotic system , which has most predominantly been examined in rheumatoid arthritis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Intestinal biopsies of 43 children with ACD and LCD were analyzed by standard indirect immunohistochemical technique for Fas , Fas ligand ( Fas L ) , tissue transglutaminase ( tTG ) , Bcl 2 , Bid , glutathione S transferase ( GST ) , CAS 3 , CAS 8 , PARP , Ki 67 , Topoisomerase IIa , PCNA expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Matrix metalloproteinase 7 ( MMP 7 ) generates soluble Fas Ligand ( FasL ) , which is involved in the apoptotic loss of CD4+ T cells during HIV infection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL ) Fas engagement proved important in this activity because elevated expression of membrane bound FasL was detected on SM DCs , and dendritic cells derived from FasL deficient mice were less capable of killing NO sensitized tumor cells than wild type dendritic cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We examined the myocardial expression of Fas , Fas ligand ( FasL ) , tumor necrosis factor ( TNF ) alpha , and TNF receptor 1 ( TNFR 1 ) , and myocardial recovery in patients from the multicenter Intervention in Myocarditis and Acute Cardiomyopathy ( IMAC ) study . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Using gld animals , Fas ligand ( FasL ) was implicated in the suppressive effects of S179D PRL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
An enhancement in Fas / APO 1 and its two forms of ligands , membrane bound Fas ligand ( mFasL ) and soluble Fas ligand ( sFasL ) , might be responsible for the apoptotic effect induced by putranjivain A . ^^^ Our study reports here for the first time that the induction of p21 / WAF1 and the activity of Fas / Fas ligand apoptotic system may participate in the antiproliferative activity of putranjivain A in MCF 7 cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand mRNA levels were increased in HBP 1 transfectants , suggesting involvement of the Fas / Fas ligand pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The purpose of this study was to compare mRNA levels of the cytotoxic lymphocyte ( CL ) gene products : granzyme B ( GB ) , perforin ( P ) , and fas ligand ( FasL ) in patients with long term type 1 diabetes and healthy controls . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In luminal Crohn ' s disease , two genetic predictors were identified : ( 1 ) patients with the Fas ligand 843 CC / CT genotype ( n = 135 ) responded in 75 % , with the TT genotype ( n = 21 ) in 38 % only ( P = 0 . 002 ; OR = 0 . 11 ; 95 % CI : 0 . 08 0 . 56 ) . ( 2 ) Patients with the caspase 9 93 TT ( n = 9 ) genotype all responded , in contrast with 67 % ( n = 147 ) with the CC and CT genotype ( P = 0 . 04 ; OR = 1 . 50 ; 95 % CI : 1 . 34 1 . 68 ) . ^^^ In the fistulizing Crohn ' s disease cohort , the same Fas ligand 843 CC / CT genotype was the only predictor of response ( P = 0 . 002 ; OR = 1 . 66 ; 95 % CI : 1 . 21 2 . 29 ) , interacting with caspase 9 93 polymorphism but not with azathioprine / mercaptopurine . ^^^ The strongest association was seen between the Fas ligand 843 TT genotype and non response . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Plasma levels of soluble Fas ( sFas ) , soluble Fas ligand ( sFasL ) , tumor necrosis factor alpha ( TNF alpha ) and interleukin 6 ( IL 6 ) were measured by enzyme linked immunosorbent assays ( ELISA ) with monoclonal anti human antibodies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble vascular cell adhesion molecule 1 ( sVCAM 1 ) and soluble Fas ligand ( sFasL ) in plasma were measured by ELISA , and intracellular activated caspase 3 fragment in different leukocytes was determined by flow cytometry . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Genet . 42 : 479 484 ) that functional polymorphisms in FAS and FAS ligand ( FASL ) are associated with susceptibility to lung cancer and esophageal cancer ; however , the mechanisms underlying this association have not been elucidated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
FAP 1 binds to FAS in a ligand dependent manner and forms a signaling complex that modulates the ability of astrocytoma cells to undergo FAS ligand ( FASL ) mediated cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We have previously demonstrated the expression of granzymes and Fas ligand in these cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Hepatitis B virus 10 protein sensitizes UV induced apoptosis by transcriptional transactivation of Fas ligand gene expression . ^^^ Therefore we examined the transactivation of Fas receptor ( Fas ) promoter and Fas ligand ( FasL ) promoter by HBx . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Binding of the intracellular Fas ligand ( FasL ) domain to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL . ^^^ The tumor necrosis factor family member Fas ligand ( FasL ) induces apoptosis in Fas receptor expressing target cells and is an important cytotoxic effector molecule used by CTL and NK cells . ^^^ PSTPIP co expression leads to an increased intracellular localization of Fas ligand , thereby regulating extracellular availability and cytotoxic activity of the molecule . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Chronic morphine treatment promotes specific Th 2 cytokine production by murine T cells in vitro via a Fas / Fas ligand dependent mechanism . ^^^ In addition , we have demonstrated a role for Fas , Fas ligand ( FasL ) , and TRAIL in promoting Th 2 development via killing of Th 1 cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Using two solid tumour cell lines , the HepG 2 hepatoblastoma carcinoma cells and MDA MB 231 breast cancer cells , we demonstrated that the Fas ligand and Fas receptor protein levels did not have significant variation after GSE incubation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
EGCG recovered UV induced loss of anti apoptotic component , bcl 2 , and inhibited UV induced apoptotic component , Fas ligand , expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Of these genes , the down regulated expression of TNFSF 6 protein , also known as Fas ligand , was confirmed in the gemcitabine resistant cell line . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas triggers apoptosis after stimulation by its ligand FasL or the Fas ligand agonist anti Fas antibody through a mitochondria dependent or independent pathway , and MSSP has been identified as a transcription factor that regulates the c myc gene and was later found to positively or negatively regulate a variety of genes , including alpha smooth actin , MHC class 1 , MHC class 2 and the thyrotropin receptor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Distinct overexpression of Fas ligand on T lymphocytes in aplastic anemia . ^^^ Increased expression of Fas by hematopoietic progenitors in aplastic anemia ( AA ) suggests that Fas / Fas ligand ( FasL ) system plays a key role in the formation of severe pancytopenia . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activation induced cell death ( AICD ) , which results from the interaction between Fas and Fas ligand , is responsible for maintaining tolerance to self antigen . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunohistochemical examination of the role of Fas ligand and lymphocytes in the pathogenesis of human liver yellow fever . ^^^ Immunoreactivity to Fas ligand was mainly observed in hepatocytes of the midzone region . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis pathways are activated in the lungs of patients with acute lung injury , in part by activation of the membrane Fas death receptor by soluble Fas ligand ( sFasL ) , which accumulates in biologically active form at the onset of lung injury . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Liver samples taken at different time points underwent histological examination for detection of apoptotic cells , and Western blotting analysis for Fas and Fas ligand , the key factors in the upper apoptotic pathways . ^^^ The anti apoptotic activity of oxymatrine depends mainly on downregulation of Fas and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The difference between the DC subtypes appeared to be at the level of initial surface molecule interactions , but could not be attributed to differences in expression of MHC class 2 or B 7 family molecules , or to the expression of Fas ligand on DC . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
But the expression of TNF cytokines ( Fas ligand and TRAIL ) was unchanged . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Lyme arthritis synovial gammadelta T cells instruct dendritic cells via fas ligand . gammadelta T cells participate in the innate immune response to a variety of infectious microorganisms . ^^^ Both of these processes are initiated primarily by Fas stimulation rather than CD 40 activation of DC via high expression of Fas ligand by the Vdelta 1 T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Their cytolytic activity against HUVECs was also increased and was effectively suppressed by Fas ligand inhibitor ( brefeldin A ) and partly by perforin inhibitor . ^^^ Therefore , CD8brightCD56+ T cells in Behet ' s uveitis are characterized by cytotoxic effector phenotypes with functional NK receptors and function as strong cytotoxic effectors through both Fas ligand dependent and perforin dependent pathways . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RKTS 33 , an epoxycyclohexenone derivative that specifically inhibits Fas ligand dependent apoptosis in CTL mediated cytotoxicity . ^^^ Cytotoxic T lymphocytes ( CTLs ) eliminate virus infected cells and tumor cells by two distinct killing pathways , mediated by lytic granules containing perforin and by Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We discovered that IFNgamma / TNFalpha synergism , rather than the Fas ligand as currently believed , is responsible for the apoptosis of pancreatic islet cells both in vitro and in vivo . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptotic cell death in toxic epidermal necrolysis : the Fas ligand assumption . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis of bovine ovarian surface epithelial cells by Fas antigen / Fas ligand signaling . ^^^ The objective of this study was to determine whether OSEs have the capacity to regulate their own demise through expression of Fas antigen ( Fas ) and Fas ligand ( FasL ) and activation of Fas mediated apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Addressing the `` Fas counterattack ' ' controversy : blocking fas ligand expression suppresses tumor immune evasion of colon cancer in vivo . ^^^ Fas ligand ( FasL / CD95L ) is a transmembrane protein belonging to the tumor necrosis factor superfamily that can trigger apoptotic cell death following ligation to its receptor , Fas ( CD95 / APO 1 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TNF but not Fas ligand provides protective anti L . major immunity in C57BL / 6 mice . ^^^ Another member of the TNF superfamily , Fas ligand ( FasL ) , has also been reported to be critical for the immune response to L . major . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Consistent with the idea that DP monocytes differentiate into DP macrophages at sites of inflammation , we found infiltration of DP macrophages at the site of myosin induced myocarditis in wild type rats ; these cells exhibited a T helper 1 ( Th 1 ) type cytokine / chemokine profile and expressed high levels of Fas ligand , perforin , granzyme B , and NKR P 2 ( rat orthologue of human NKG2D ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
DNA damage was investigated by immunofluorescent TUNEL labelling in combination with apoptotic cell morphology and by visualization of a major signalling system of apoptosis , Fas FasL ( Fas ligand ) , by the immunoperoxidase technique . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The APO 1 / Fas receptor death induction pathway was not activated under the influence of BJE , as studied by staining with Fas ligand and Fas receptor specific antibodies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Elimination of rheumatoid synovium in situ using a Fas ligand ' gene scalpel ' . ^^^ Gene transfer of Fas ligand ( FasL ) has increased the frequency of apoptotic cells in mouse and rabbit arthritic synovium . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand by hepatic macrophages in patients with fulminant hepatic failure . ^^^ OBJECTIVES : The mechanisms of Fas Fas ligand ( Fas FasL ) mediated apoptosis in the pathogenesis of fulminant hepatic failure ( FHF ) have not been well defined . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand is localized to membrane rafts , where it displays increased cell death inducing activity . ^^^ Fas ligand ( FasL ) , a member of the TNF protein family , potently induces cell death by activating its matching receptor Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
One reason for this in the context of OS lung metastases may be that Fas positive cells are eliminated by engagement with the Fas ligand ( FasL ) constitutively expressed on the surface of pneumocytes , whereas Fas negative tumor cells are not . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We demonstrate that TGF beta acts on cytotoxic T lymphocytes ( CTLs ) to specifically inhibit the expression of five cytolytic gene products namely , perforin , granzyme A , granzyme B , Fas ligand , and interferon gamma which are collectively responsible for CTL mediated tumor cytotoxicity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand reduces viability in primary melanoma short term cell cultures more than in metastatic melanoma short term cell cultures . ^^^ OBJECTIVE : Effect of soluble Fas ligand ( sFasL ) and tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) on short term cultured melanoma cell viability from different stages of melanoma . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand expression was increased in HIV infection in both CD8+CD57+ and CD8+CD57 lymphocytes , though a significantly greater percentage of CD8+CD57+ cells expressed this marker . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A few examples have been provided , such as the transcription factor NF kappaB , the transcription repressor Yin Yang 1 ( YY 1 ) , the pro apoptotic gene product ( Smac / DIABLO ) and the circulating Fas and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here we report that UV C but not Fas ligand treatment results in a significant decrease in intracellular chloride that can be abolished by modulation of chloride flux using either the chloride channel inhibitor SITS or medium with a reduced chloride concentration . ^^^ Accordingly , downstream events are diminished during UV C induced apoptosis following chloride flux modulation , whereas Fas ligand induced apoptotic characteristics are not affected . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interaction of Fas ligand and Fas expressed on osteoclast precursors increases osteoclastogenesis . ^^^ We incidentally found that osteoclast precursors and mature osteoclasts express Fas ligand ( FasL ) as well as Fas , which was confirmed by flow cytometry , immunofluorescent staining , and RT PCR . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis of antigen specific T lymphocytes upon the engagement of CD 8 by soluble HLA class 1 molecules is Fas ligand / Fas mediated : evidence for the involvement of p56lck , calcium calmodulin kinase 2 , and Calcium independent protein kinase C signaling pathways and for NF kappaB and NF AT nuclear translocation . ^^^ The binding of soluble HLA class 1 ( sHLA 1 ) molecules to CD 8 on EBV specific CTL induced up regulation of Fas ligand ( FasL ) mRNA and consequent sFasL protein secretion . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Opposite roles of FAP 1 and dynamin in the regulation of Fas ( CD 95 ) translocation to the cell surface and susceptibility to Fas ligand mediated apoptosis . ^^^ Treatment of these melanoma lines with soluble Fas ligand resulted in programmed cell death that was proportional to the pre existing levels of surface Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
An enhancement in Fas / APO 1 and its two form ligands , membrane bound Fas ligand ( mFasL ) and soluble Fas ligand ( sFasL ) , was responsible for the apoptotic effect induced by chalcone . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Malignant growth is associated with various patterns of interaction between tumor cells and those of the body immune system , interaction between Fas receptor ( Fas ) and Fas ligand ( FasL ) expression being one of them . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Since this molecule possesses multiple functions , including apoptosis inhibition , cell cycle promotion and enhancement of Fas ligand expression , survivin has attracted growing attention as a target in cancer treatment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Administration of poly 1 : C caused NKT and T cell apoptosis via enhancing expression of Fas protein on these cells and expression of Fas ligand on NK cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Upstream , the apoptotic signaling involved activation of caspases 8 and 3 and up regulation of Fas ligand mRNA , whereas calpain mediated cell death depended on elevated intracellular free Ca ( 2+ ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interfering with the Fas FasL interaction with recombinant Fas or an antibody against Fas ligand partially inhibited apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
As a death factor of T cells and Natural Killer ( NK ) cells , Fas Ligand ( FasL ) is stored in association with secretory lysosomes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunohistochemical detection of CD 95 ( Fas ) & Fas ligand ( Fas L ) in plasma cells of multiple myeloma and its correlation with survival . ^^^ Fas ligand ( Fas L ) , a member of the tumor necrosis factor family , induces apoptosis mediated via its transmembrane death receptor Fas ( Apo 1 / CD95 ) antigen . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunofluorescence assay combined with laser scanning confocal microscopy revealed that both Fas and Fas ligand ( FasL ) were up regulated by the small molecule . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Treatment with Fas ligand ( FasL ) , Fas activating antibody , or TRAIL failed to induce cell death in ( + ) SA neoplastic mammary epithelial cells , suggesting that these cells are resistant to death receptor induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
HSV 1 enhanced the expression of both Fas and Fas ligand on the surface of neonatal neutrophils . ^^^ Treatments with anti Fas antibody and a Fas ligand inhibitor significantly reduced the induction of apoptosis by HSV 1 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas / Fas L system is a widely recognized apoptosis signal transduction pathway in which transmembrane receptor protein ( Fas ) triggers a programmed cell death when bound by the Fas ligand ( Fas L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , Fas ligand ( FasL ) deficient mice on a C57BL6 ( B 6 ) background were used as donors , to determine the significance of the Fas FasL system for the antitumor effect . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Agonistic anti Fas antibodies and multimeric recombinant Fas ligand ( FasL ) preparations show high tumoricidal activity against leukemic cells , but are unsuitable for clinical application due to unacceptable systemic toxicity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In T cells , Fas ligand expression is tightly regulated at a transcriptional level through the activation of a distinct set of transcription factors . ^^^ Increasing evidence , however , supports an important role for posttranscriptional regulation of Fas ligand expression and activity . ^^^ Here , we now provide evidence that Fas ligand is constitutively localized in lipid rafts of FasL transfectants and primary T cells . ^^^ Importantly , disruption of lipid rafts strongly reduces the apoptosis inducing activity of Fas ligand . ^^^ Localization to lipid rafts appears to be predominantly mediated by the characteristic cytoplasmic proline rich domain of Fas ligand because mutations of this domain result in reduced recruitment to lipid rafts and attenuated Fas ligand killing activity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The apoptosis was less related to the fas ligand than to TNF alpha . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The results would suggest that INF gamma and other cytokines released by activated macrophages , possibly functioning through the INF gammaR 1 , Fas ligand , CD 95 or other death ligands in the trypanosome plasma membrane initiates the apoptosis cascade in trypanosomes . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Olmesartan significantly decreased the expression of IFN gamma ( interferon gamma ) , FasL ( Fas ligand ) , iNOS ( inducible nitric oxide synthase ) and PFP ( pore forming protein ) in myocardial tissue , indicating that olmesartan suppressed the activation of infiltrating killer lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ellipticine treatment was found to result in the upregulation of p 53 , Fas / APO 1 receptor and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand induces cell autonomous IL 23 production in dendritic cells , a mechanism for Fas ligand induced IL 17 production . ^^^ Fas ligand ( FasL ) has the potential to induce inflammation accompanied by massive neutrophil infiltration . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
ANG 2 induced apoptosis was characterized by marked inhibition of Akt phosphorylation and stimulation of membrane Fas ligand ( FasL ) expression , caspase 8 activation , and a reduction in soluble FasL expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
By confocal microscopic analysis of agonist stimulated rafts patch formation , we found that several death receptor ligands or apoptotic factors , including tumor necrosis factor alpha , Fas ligand , or endostatin , stimulated the clustering and trafficking of individual LRs on the plasma membrane of coronary endothelial cells . ^^^ Interestingly , double labeling of a membrane bound NADPH oxidase subunit , gp91phox , and LRs showed that gp91phox colocalized within the LR patches when endothelial cells were stimulated by Fas ligand . ^^^ Functionally , Fas ligand induced inhibition of endothelium dependent vasorelaxation was reduced if LRs were disrupted or NADPH oxidase was inhibited . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Circulating levels of soluble Fas ligand in cachexic patients with COPD are higher than those in non cachexic patients with COPD . ^^^ The purpose of this study is to assess the potential role of the Fas Fas ligand ( FasL ) system in cachexic patients with COPD . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition to effects on GrB , VIP also down regulates Fas ligand ( FasL ) and perforin ( Pfr ) expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Vascular endothelial growth factor and hypoxia inducible factor 1 alpha are also important for placental angiogenesis while trophoblastic expression of Fas ligand is thought to protect conceptuses against immune mediated pregnancy loss . ^^^ In arresting fetal sites , uterine lymphocytes had no angiogenic gene transcription and showed rapid elevation in transcription of proinflammatory cytokines Fas and Fas ligand while trophoblasts showed elevated transcription of IFN gamma and Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Decoy receptor 3 ( DcR 3 ) , a soluble receptor for Fas ligand , LIGHT ( homologous to lymphotoxins shows inducible expression and competes with HSV glycoprotein D for herpes virus entry mediator , a receptor expressed by T lymphocytes ) , and TNF like molecule 1A , is highly expressed in cancer cells and in tissues affected by autoimmune disease . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Selective induction of cyclooxygenase 2 plays a role in lysophosphatidic acid regulated Fas ligand cell surface presentation . ^^^ Previous studies found that lysophosphatidic acid ( LPA ) upregulated Fas ligand ( FasL ) presentation on the ovarian cancer cell surface and lead to apoptosis of activated lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Membrane bound Fas ligand ( FasL ) is cleaved into soluble FasL , which increases apoptosis of cells adjacent to tumor cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In H9C2 cells , NAC pretreatment blocked cocaine mediated increases in CRP , FAS , FAS ligand , and cytokine receptor like factor 1 ( CRLF 1 ) expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The aim of this study was to investigate whether apoptosis may contribute to the pathogenesis of epidermal changes in dermatitis herpetiformis ( DH ) and , in particular , whether certain apoptosis related markers such as Bax , Bcl 2 , Fas and Fas ligand ( FasL ) take part in this process . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We found numerous genes showing upregulation associated with increased storage time , including CD 30 , CD 30 ligand , Fas , Fas ligand , tumor necrosis factor alpha , and several caspases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Detection of the soluble form of Fas ligand ( sFasL ) and sFas in the saliva from patients with Sjgren ' s syndrome . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Constitutive activation of the aryl hydrocarbon receptor in T lineage cells induces thymus involution independently of the Fas / Fas ligand signaling pathway . ^^^ In the present study , we examined the involvement of Fas / Fas ligand ( FasL ) dependent apoptosis , a likely mechanism suggested by previous studies , in the thymocyte loss by AhR activation of thymocytes . ^^^ In this study , we crossed the T cell specific CA AhR Tg mice with Faslpr mice , which have the homozygous defective fas ( lpr ) gene , or with FasLgld mice , which have the homozygous mutated fas ligand ( gld ) gene , to generate mice that are defective in Fas / FasL signaling and express the CA AhR in T lineage cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
ROS and lipid peroxidation products also increase the generation of several cytokines ( TNF alpha , TGF beta , Fas ligand ) playing a key role in cell death , inflammation and fibrosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This study investigated the association of apoptosis related genes on chromosome 1q , Fas ligand ( FasL ) , interleukin ( IL ) 10 and poly ( ADP ribose ) polymerase ( PARP ) , promoter microsatellite multi allelic polymorphisms with SLE susceptibility and clinical characteristics in Taiwan . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A role for Fas Fas ligand interactions during the late stage neuropathological processes of experimental cerebral malaria . ^^^ Using a murine model of CM , we investigated the role of Fas Fas ligand interactions in the neuropathogenesis of this disease . ^^^ Lpr and Gld mice , deficient in Fas and Fas ligand , respectively , were protected from fatal CM , although they demonstrated some pathological features associated with CM in the wild type mouse . ^^^ Fas Fas ligand mRNA and protein expression were increased in the brain in mice with CM , and activated caspase 3 positive apoptotic astrocytes were observed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Oral vaccination against Helicobacter pylori infection is not effective in mice with Fas ligand deficiency . ^^^ C57BL / 6 and Fas ligand deficient ( gld ) mice were divided into 3 groups : control , H . pylori infected , and orally vaccinated ( H . pylori whole cell sonicate and cholera toxin adjuvant ) . ^^^ Oral vaccination is not effective in Fas ligand deficient mice likely owing to lack of effective cytokine responses . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To investigate association of apoptosis in the pathogenesis of EBV associated HLH , the serum EBV loads , and serum concentrations of soluble tumor necrosis factor receptor 1 ( sTNF R 1 ) , soluble Fas ligand , and cytochrome c were examined in 15 patients with EBV associated HLH and 24 patients with infectious mononucleosis ( IM ) . ^^^ On the other hand , there were no statistically significant differences in the concentrations of soluble Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : HLE , SKHep 1 , and HepG 2 were incubated and E 3330 was used to compare the stimulation of some chemotherapeutic drugs with that of TNF family , Fas ligand , TNF alpha and TNF related apoptosis inducing ligand ( TRAIL ) at the point of the reduction of cell viability by inhibiting NF kappa B . ^^^ The cytotoxicity of the combination of TRAIL , TNF alpha , Fas ligand , and E 3330 increased synergistically in a dose dependent manner compared to either E 3330 alone in all HCC cell lines by MTT assay . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To investigate the mechanism of apoptosis induced by nucleosides , it was found that the contents of soluble Fas ligand contents were increased in HepG 2 cells following 1 , U , T , and A treatment ( P < 0 . 05 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Exosomes isolated from pregnancies subsequently delivering at term expressed significantly higher levels of biologically active components , including Fas ligand ( FasL ) and HLA DR , than those from pregnancies delivering preterm . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RNA was extracted from the articular cartilage and menisci of the affected knee and was examined with regard to expression of the following genes : Caspase 8 , Fas , Fas ligand ( Fas L ) , p 53 , aggrecanase , matrix metalloproteinase ( MMP ) 1 , and MMP 3 MMP 13 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand deficiency impairs host inflammatory response against infection with the spirochete Borrelia burgdorferi . ^^^ Synovial tissues of inflamed joints contain cells expressing high levels of Fas and Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The monoclonal antibodies used included those to CD1a , CD 4 , CD 8 , CD 40 , CD40L , CD 68 , Fas , Fas ligand ( FasL ) and myeloperoxidase . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Irregularly shaped inclusion cysts display increased expression of Ki 67 , Fas , Fas ligand , and procaspase 3 but relatively little active caspase 3 . ^^^ Fas , Fas ligand , and caspase 3 , components of the apoptotic pathway , were also largely absent . ^^^ Ki 67 , Fas , Fas ligand , and procaspase 3 expression , though not active caspase 3 expression , was more frequently observed in epithelial cells lining irregularly shaped inclusion cysts , particularly in the columnar and Mllerian like OSE cell types that resembled ovarian tumor OSE cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Possible role of Fas / Fas ligand mediated apoptosis in the pathogenesis of fixed drug eruption . ^^^ We then examined the expressions of Fas and Fas ligand ( FasL ) to deduce the possible upstream signalling pathway of apoptosis , if apoptosis were involved . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis , in contrast , represents the execution of an ATP dependent death program often initiated by death ligand / death receptor interactions , such as Fas ligand with Fas , which leads to a caspase activation cascade . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Perforin , Fas ligand ( FasL ) and granzyme B were detected at mRNA level in indicated culture conditions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We examined expression and function of death receptors for Fas ligand and TRAIL in human MC . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The hearts isolated from Fas receptor or Fas ligand knockout ( KO ) mice as well as the C57BL / 6J wild type control mice ( N = 6 8 per group ) were subjected to 20 min of global ischemia and 30 min of reperfusion in Langendorff mode . ^^^ Our results show that the infarct size , determined with triphenyltetrazolium chloride staining , was not significantly different between the three groups ( i . e . , 30 . 2 + / 3 . 9 % for wild type controls , 30 . 0 + / 2 . 1 % for Fas ligand KOs , and 23 . 8 + / 3 . 6 % for Fas receptor KOs ; mean + / SEM , p > 0 . 05 ) . ^^^ In conclusion , contrary to our original hypothesis , the present study in the gene KO mice suggests that the Fas ligand and Fas receptor mediated death receptor pathway of apoptosis is not the primary determinant of myocardial infarct size and ventricular dysfunction caused by acute global 1 R injury in the isolated perfused mouse heart . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Estrous cycle dependent changes in expression and distribution of Fas , Fas ligand , Bcl 2 , Bax , and pro and active caspase 3 in the rat ovary . ^^^ Fas , Fas ligand , Bcl 2 , Bax and caspase 3 mRNA expression and proteins were detected in all ovarian tissue extracts , though the amount of protein varied with the phase of the estrous cycle . ^^^ In contrast , Fas ligand and Bcl 2 protein levels were lowest at diestrus and increased toward metestrus . ^^^ In contrast , the pro apoptotic proteins Fas , Fas ligand , Bax and active caspase 3 were more predominantly present in atretic follicles . ^^^ Fas ligand and Bax staining was detected particularly during proestrus in OSE cells surrounding the ovulatory follicles , while active caspase 3 was observed only in OSE cells at the postovulatory site during estrus . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the adult , inflammatory cells entering the eye are exposed to the pro apoptotic agents transforming growth factor beta 2 and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activated T cells undergo apoptosis when the Fas antigen ( APO 1 , CD 95 ) is ligated by Fas Ligand ( FasL ) or agonistic anti Fas antibodies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Death ligands and receptors , such as tumor necrosis factor and Fas ligand , proapoptotic and antiapoptotic Bcl 2 family members and caspases have all been shown to participate in apoptosis regulation in the course of renal cell injury . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : We observed the cytotoxic effect of cytotoxic T lymphocyte ( CTL ) ( CD8+ ) and natural killer cells ( CD 3 CD16+ CD56+ ) toward chronic ITP patient ' s autologous platelets , and investigated the expression of Fas ligand ( FasL ) , tumor necrosis factor ( TNF ) alpha and TNF related apoptosis inducing ligand , as well as perforin and granzyme B mRNA in CD8+ cells using flow cytometry and reverse transcriptase polymerase chain reaction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The RelA / NF kappaB PKCdelta JNK pathway is critical for UV induced apoptosis , as it induces the immediate expression of the proapoptotic Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Dual treatment with COX 2 inhibitor and sodium arsenite leads to induction of surface Fas Ligand expression and Fas Ligand mediated apoptosis in human melanoma cells . ^^^ Most human melanomas express Fas receptor on the cell surface , and treatment with exogenous Fas Ligand ( FasL ) efficiently induces apoptosis of these cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas ligand expression on germinal center type diffuse large B cell lymphoma is associated with the clinical outcome . ^^^ The protein Fas induces apoptosis of lymphocytes by binding with the Fas ligand ( FasL ) , and escape from such apoptosis is considered to lead to malignant transformation of the cells and unrestricted growth of lymphoma . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Experiment 2 : two blastomere embryos were divided into 3 groups : ( A ) cultured in standard IVF medium ( control ) ; ( B ) cultured in standard IVF medium with Fas L ( 500 ng / mL ) ; ( C ) cultured in standard IVF medium with Fas ligand ( 500 ng / mL ) and SCF ( 100 ng / mL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We included fas ligand ( FasL ) , transforming growth factor beta 1 ( TGF beta 1 ) and clusterin as the immune protective molecules , and follicle stimulating hormone receptor ( FSHR ) , p27Kip1 , GATA 4 and Wilm ' s tumor antigen ( WT 1 ) as Sertoli cell proliferation markers . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , the absence of a functional PPAR alpha gene enhanced the staining ( immunohistochemistry ) for FAS ligand in the paw and in the lung and the expression of tumor necrosis factor alpha and interleukin 1beta in the lungs of carrageenan treated mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas expression is particularly induced in beta cells by inflammatory cytokines secreted by islet infiltrating mononuclear cells and makes cells susceptible to apoptosis by interaction with Fas ligand expressing cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
While both drugs reduced the expression of Fas ligand ( FasL ) and caspase 8 , treatment with hCDR 1 resulted in reduced whereas dexamethasone administration resulted in increased rate of apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
As a result , Tat JBD diminished the increased phosphorylation of c Jun ( a nuclear substrate of JNK ) and the increased expression of Fas ligand induced by ischemia / reperfusion in the vulnerable hippocampal CA 1 subregion . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here we show that binding of Fas ligand to Fas activates p 38 MAPK in CD8+ T cells and that activation of this pathway is required for Fas mediated CD8+ T cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Nine diallelic polymorphisms ( gene and SNP descriptor ) were studied in subjects : cytotoxic T lymphocyte antigen 4 ( CTLA 4 , 49 A > G ) , human beta defensin 1 ( DEFB 1 , 692 G > A ) , intercellular adhesion molecule 1 ( ICAM 1 , 1548 A > G ) , Fas ligand ( fasL , 844 C > T ) , inducible costimulator ( ICOS , 3990 G > T ) , interleukin 6 ( IL 6 , 174 G > C ) , cysteine cysteine chemokine receptor 5 ( CCR 5 , 59653 C > T ) , osteoprotegerin ( OPG , 245 T > G ) , and osteopontin ( OPN , 707 C > T ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The tumour necrosis factor ( TNF ) receptor family is involved in the regulation of cellular homeostasis , cell surface molecules involved in phagocytosis , Fas ligand ( L ) expression and activation of the caspase cascade resulting in DNA fragmentation and cell blebbing . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Western blot analysis revealed that ISL increased the levels of membrane bound Fas ligand ( FasL ) , Fas , cleaved casapse 8 , truncated Bid ( tBid ) , Bax and Bad in DU 145 cells ( P < . 05 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this study , we made use of an adoptive transfer model of experimental lung metastasis using tumor specific CTL as a relevant immune based selective pressure , and wherein the Fas ligand pathway was involved in the antitumor response . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Significant up regulation of tumor necrosis factor ( TNF ) related apoptosis inducing ligand ( TRAIL ) and TNF alpha , but not Fas ligand ( FasL ) mRNA , was detected in human monocyte derived macrophages ( MDMs ) infected with avian influenza viruses A / Hong Kong / 483 / 97 ( H5N1 / 97 ) or its precursor , A / Quail / Hong Kong / G1 / 97 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Inhibitory effects of stimulated SNS on MS may occur via different ways such as inhibiting the production of pro inflammatory cytokines and inducing the synthesis of anti inflammatory cytokines , in other words , shifting the immune responses from type 1 toward type 2 , as well as , induction of suppressor / regulator T lymphocytes , induction of heat shock proteins in brain and increasing the expression of Fas and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Further elucidation of downstream signaling events revealed that CD 45 modulates HIV 1 gp 120 induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3 kinase / Akt pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Moreover , evidence suggests that cell lines expressing high levels of 170 kDa P gp are less sensitive to caspase mediated apoptosis induced by a wide range of death stimuli , including Fas ligand , tumor necrosis factor , and ultraviolet irradiation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Functional polymorphisms in the promoter regions of the FAS and FAS ligand genes and risk of bladder cancer in south China : a case control analysis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Polymorphisms of the FAS and FAS ligand genes associated with risk of cutaneous malignant melanoma . ^^^ The FAS / FAS ligand ( FASLG ) system has a key role in regulating cell growth and thus tumorigenesis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , both levels of Fas mRNA in liver tissues and Fas Ligand in spleen cells were up regulated at 6 h after the elicitation . ^^^ The Fas mRNA expression was maintained in a relatively high level at 18 h while Fas Ligand began to decrease after 12 h . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Inducing apoptosis and upregulation of Bax and Fas ligand expression by allicin in hepatocellular carcinoma in Balb / c nude mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this study , we investigated the in vitro and in vivo efficacy of Fas ligand ( FasL ) gene therapy for the treatment of head and neck cancer . ^^^ Three head and neck squamous cell carcinoma ( HNSCC ) cell lines ( SCC 1 , SCC 12 , and SCC 14a ) were treated with the Fas agonist CH 11 , a monoclonal antibody to the Fas receptor , or with a replication incompetent adenovirus ( AdGFPFasL ) expressing a modified murine Fas ligand gene fused to green fluorescent protein ( GFP ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The selected resistant cells were cross resistant to Fas ligand but remained sensitive to drug induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Human astrocytes are resistant to Fas ligand and tumor necrosis factor related apoptosis inducing ligand induced apoptosis . ^^^ This study has therefore identified the molecular mechanisms that protect normal human astrocytes from apoptosis induced by Fas ligand and TRAIL . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this study we elaborate on the immune response and mechanisms of persistence of mycobacteria in lesions by analysing , using immunohistochemistry , the expression of cytokines [ tumour necrosis factor alpha ( TNF alpha ) , interleukin 10 ( IL 10 ) , transforming growth factor beta ( TGF beta ) and interferon gamma ( IFN gamma ) ] , apoptotic cells and apoptosis related proteins [ Bcl 2 , Bax , Fas ligand ( FasL ) and Fas ] in the human tuberculous lymphadenitis lesions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Neutralization of tumor necrosis factor alpha or Fas ligand had no effect on apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expressions of Fas , Fas ligand , and TNF alpha type 1 receptor were enhanced in fasting and I / R rats . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of DAP kinase , Fas , and Fas ligand ( FasL ) proteins was studied by immunohistochemistry and immunofluorescence . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Unexpectedly , exogenous NO triggers expression of Fas ligand ( FasL ) in cultured motoneurons . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The adaptor protein Nck interacts with Fas ligand : Guiding the death factor to the cytotoxic immunological synapse . ^^^ The Fas ligand ( FasL ) is a key death factor of cytotoxic T lymphocytes and natural killer cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL / CD95L / TNFSF6 ) , a member of the tumor necrosis factor family , initiates apoptosis in lymphoid and nonlymphoid tissues by binding to its receptor Fas ( CD95 / TNFRSF6 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We confirm , by using deficient mice , neutralizing antibodies and recombinant cytokines , that IL 4 induced apoptosis is not related to the well known apoptosis inducing factors Fas , Fas ligand , TNF alpha , TRAIL , TGF beta or perforin . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Neither TNF alpha nor Fas ligand levels were changed in pancreatic acinar cells after crambene treatment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The majority of patients have heterozygous mutations in the FAS ( TNFRSF 6 ) gene , but the condition is genetically heterogeneous and mutations in FAS ligand and caspase 8 and caspase 10 , all of which are involved in Fas mediated signalling , have also been identified . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand is one such molecule whose cell surface expression on T cells is dramatically up regulated upon activation . ^^^ The rationale being to selectively target activated T cells via binding of its Fas moiety to cell surface Fas ligand , and then to allow the Fc moiety to invoke its usual effector mechanisms resulting in the destruction of the allo activated T cell . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the supernatant of PBMC culture incubated with Borrelia burgdorferi antigens concentrations of potentially anti apoptotic factors : soluble receptor for tumor necrosis factor alpha ( sTNF RI ) , soluble Fas ( sFas ) and soluble Fas ligand ( sFasL ) , as well as the concentration of transforming growth factor beta ( TGF beta ) , cytokine synthesized in the final stage of apoptosis , were measured by ELISA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Because 2 methoxyestradiol is able to trigger death receptor signaling , we were interested in examining the effects of 2 methoxyestradiol and Fas ligand ( FasL ) / tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) together on pancreatic cancer cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NK cells in the liver of young mice were mainly CD 69 ( + ) Mac 1 ( ) Fas ligand ( + ) , whereas those in the liver of adult mice were CD 69 ( ) Mac 1 ( + ) Fas ligand ( ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
As a result , the inhibition of JNK activation by Tat GluR 6 9c diminished the phosphorylation of the transcription factor c Jun and down regulated Fas ligand expression in hippocampal CA 1 and CA3 / DG regions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A homozygous Fas ligand gene mutation in a patient causes a new type of autoimmune lymphoproliferative syndrome . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Enterovirus 71 infection induces Fas ligand expression and apoptosis of Jurkat cells . ^^^ In addition , the expression of Fas ligand ( FasL ) in EV 71 infected Jurkat cells increased at both mRNA and surface expression levels . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We also demonstrated that platycodin D mediated apoptosis of HaCaT cells upregulates Fas receptor and Fas ligand ( FasL ) expression , but did not exhibit p 53 activation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In particular , we found that T cells expressing Fas ligand ( Fas L , CD95L ) were eight times more vulnerable to apoptosis than those not expressing Fas L , which suggests that the T cell apoptosis is induced by overactivation of the T cell receptor , possibly in the absence of appropriate costimulation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Moreover , the expressions of Fas ligand , caspase 8 , and caspase 9 in the aortic arches were also markedly lowered after M . officinalis and lovastatin supplements . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , the immune cutaneous antibody induced theront apoptosis ; however , Fas ligand did not . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
When bound to its ligand , Fas ligand ( Fas L ) , it triggers apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cholesterol depletion , after Fas ligand activation of apoptosis , reduced raft formation in cells induced to undergo apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand mediated lethal hepatitis after rapid lysis of a localized natural killer cell lymphoma . ^^^ Natural killer ( NK ) cell malignancies have been associated with neutropenia and disturbances of liver function tests , thought to be related to high levels of soluble Fas ligand ( FasL ) in the circulation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Perforin , Granzyme B , and fas ligand for molecular diagnosis of acute renal allograft rejection : analyses on serial biopsies suggest methodological issues . ^^^ BACKGROUND : The Perforin Granzyme B and Fas / Fas Ligand apoptotic mechanisms are involved in the development of acute renal rejection ( AR ) . ^^^ METHODS : We analyzed Perforin ( P ) , Granzyme B ( GB ) and Fas Ligand ( FL ) expression in 68 renal biopsies and 64 PBL using comparative kinetic RT PCR and , for GAPDH and FL , we also replicated with real time RT PCR . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
IFN gamma enhances NK cell cytotoxicity by causing an increase in the levels of expression of TRAIL and Fas ligand . ^^^ The production of IFN gamma , one of the NF kappaB target genes in NK cells , was also found to be suppressed by adiponectin , accompanied by the subsequent down regulation of IFN gamma inducible TRAIL and Fas ligand expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand is responsible for CXCR 3 chemokine induction in CD4+ T cell dependent liver damage . ^^^ Fas / Fas ligand ( FasL ) interaction plays a critical role in immune mediated hepatic damage . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The signaling pathway is coupled to adenylate cyclase activation , induction of the Nur 77 transcription factor , Nur 77 dependent genes , such as Fas ligand and TRAIL , and the pro apoptotic BH 3 only protein Bim . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We postulate that the Fas ligand ( FasL ) derived from the infiltrating mononuclear cells causes death of cardiac cells resulting in the development of heart failure . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand and CTLA 4 in adenoids has a predictive value for allergic rhinitis development in children . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recent work using transection models of spinal cord injury ( SCI ) demonstrated that neutralization of Fas ligand with antibodies may promote axonal regeneration and functional recovery . ^^^ The present paper examines the effects of soluble Fas receptor ( sFasR ) administration on inhibition of Fas receptor Fas ligand interaction in the setting of acute SCI in vitro and in vivo . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To evaluate the expression patterns of apoptosis related proteins , including Fas , Fas ligand ( FasL ) , caspase 3 and Bcl 2 , in various cellular components of ameloblastomas , 39 cases of ameloblastoma were examined using immunohistochemistry . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We found that the stimulation of Fas expressed on DCs with Fas ligand ( FasL ) did not induce apoptosis of DCs but rather enhanced the antigen presentation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis signalling through the Fas pathway requires several steps of aggregation of the Fas receptor in the membrane , including aggregation that may occur in the absence of Fas ligand . ^^^ Association of Fas domains is determinant to signal transmission following Fas ligand binding to a specific domain . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Rejection requires CD4+ , CD8+ , and NK1 . 1+ cells and is dependent on IFN gamma and Fas ligand and independent of perforin . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These mice lack functional Fas ( CD 95 ) expression and are resistant to Fas ligand ( CD 178 ) mediated apoptosis , a critical mechanism for the maintenance of peripheral tolerance . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Diagnostic role of soluble fas ligand secretion by peripheral blood mononuclear cells from patients with previous drug induced blistering disease : a pilot study . ^^^ The aim of this study is to explore the diagnostic role of soluble Fas ligand secretion by peripheral blood mononuclear cells ( PBMCs ) in patients with previous drug induced blistering diseases with or without stimulation with the offending drug . ^^^ The results revealed that PBMCs from the patient group showed significant soluble Fas ligand secretion after stimulation with 100 microg / ml culprit drug ( p < 0 . 05 ) . ^^^ Taken as a group , PBMCs from the patient group secreted more soluble Fas ligand than the normal control group regardless of drug stimulation . ^^^ These results indicate that individuals whose PBMCs are high secretors of soluble Fas ligand are prone to severe toxic epidermal necrolysis / Stevens Johnson syndrome . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Comparison was made between the infected and non infected group for the following parameters : ascites leukocyte counts and differentiations ; ascitic fluid protein ; albumin levels and serum ascites albumin gradients ; flow cytometric detection of cell surface markers for ascitic T , B and natural killer lymphocytes ; intracytoplasmic interleukin ( IL ) 2 , IL 4 , tumor necrosis factor ( TNF ) alpha and interferon ( IFN ) gamma ; levels of ascitic IL 8 , IL 10 , IL 12 and TNF alpha ; and soluble Fas antigen and soluble Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Experiments were conducted to test whether oestradiol ( E 2 ) protects granulosa cells from Fas ligand ( FasL ) induced apoptosis and whether protection involves modulation of the cell cycle of proliferation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand mediated paracrine T cell regulation by the receptor NKG2D in tumor immunity . ^^^ In late stage human tumor settings , we observed MIC driven proliferation of NKG2D ( + ) CD 4 ( + ) T cells that produced the cytokine Fas ligand ( FasL ) as a result of NKG2D costimulation but were themselves protected from Fas mediated growth arrest . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CVID patients who had both increased numbers of LGL and granulocytopenia had elevated levels of soluble Fas ligand ( sFasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A variety of tumor derived factors contribute to the emergence of complex local and regional immunosuppressive networks , including vascular endothelial growth factor , interleukin 10 , transforming growth factor beta , prostaglandin E ( 2 ) , and soluble phosphatidylserine , soluble Fas , soluble Fas ligand , and soluble MHC class 1 related chain A proteins . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cytochrome c was examined by immunohistochemical stain , and Fas , Fas ligand , Bax , Bcl 2 , and ERK activation ( p ERK / ERK ) were analyzed by Western blotting analysis . ^^^ Fas was not expressed in both control and GRGD treated podocytes , although Fas ligand was upregulated in GRGD treated cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
ICOS ( / ) CD 4 ( + ) T cells had no defect in expansion , but expressed significantly less Fas ligand and produced significantly lower levels of IFN gamma and TNF alpha . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , the results point to a role for Fas ligand in the regulation of this response . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Gld mutation of Fas ligand increases the frequency and up regulates cell survival genes in CD25+CD4+ TR cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Glucocorticoids have been implicated in the inhibition of activation induced T cell apoptosis by virtue of their down regulation of Fas ligand ( fasL ) expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In vivo analysis of adenovirus specific cytotoxic T lymphocyte response in mice deficient in CD 28 , fas ligand , and perforin . ^^^ In this study , we used a novel MHC class 1 tetramer and an in vivo CTL assay to examine the role of CD 28 , perforin , Fas ligand ( FasL ) , and TNF alpha in the generation and function of Ad specific CTLs in vivo . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Proinflammatory gene expression was measured using RNase protection assays ( tumor necrosis factor [ TNF ] alpha , TNF alpha receptor p 55 , interleukin [ IL ] 1alpha , IL 1beta , IL 6 , macrophage inflammatory peptide 2 , intercellular adhesion molecule 1 , Fas ligand , and inducible nitric oxide synthase ) and ELISAs ( TNF alpha , IL 6 , and macrophage inflammatory peptide 2 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand mRNA levels of circulating leukocytes reflect endothelial dysfunction in hyperlipidemic but not in non hyperlipidemic patients . ^^^ To find a novel marker for identifying patients at high risk for endothelial dysfunction among patients with atherosclerosis , we examined the correlation between mRNA levels of Fas ligand ( FasL ) , an apoptosis inducing factor , in circulating leukocytes and clinical parameters in these patients . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Measures were mucosal apoptosis , proliferation , villous morphology , and apoptotic and proliferative mediators , such as caspase 3 and caspase 7 , Fas and Fas ligand , Bcl 2 , and Bax . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Many tumors are resistant to Fas ligand ( FasL ) induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Pneumocystis cell wall beta glucans induce dendritic cell costimulatory molecule expression and inflammatory activation through a Fas Fas ligand mechanism . ^^^ Because cytokine secretion by DCs has recently been shown to be regulated by Fas ligand ( FasL ) , its role in beta glucan activation of DCs was also investigated . beta Glucan induced DC activation occurred in part through dectin 1 receptors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptotic lymphocytes , observed from 20 h post ECP , are associated with enhanced levels of CD 95 and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Evaluation of changes in gene expression profile indicates that EGCG treatment activates distinct pathways of growth arrest and apoptosis in MM cells by inducing the expression of death associated protein kinase 2 , the initiators and mediators of death receptor dependent apoptosis ( Fas ligand , Fas , and caspase 4 ) , p 53 like proteins ( p 73 , p 63 ) , positive regulators of apoptosis and NF kappaB activation ( CARD 10 , CARD 14 ) , and cyclin dependent kinase inhibitors ( p 16 and p 18 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although main site of apoptosis in SLE is considered as lymphocytes , we experienced a case with SLE who had liver dysfunction with elevated soluble Fas ligand ( sFasL ) and apoptosis in her hepatocytes in the active stage of SLE . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the present study , we tried to delineate the effect of testosterone on the apoptosis of bone marrow derived macrophages ( BMMs ) and the function of Fas / FasL ( Fas ligand ) pathway in this course . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The cytoplasmic domain of Fas ligand costimulates TCR signals . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
At 3 d , the increased gene expression of interferon gamma ( IFNgamma ) was associated with an enhanced mRNA level of Fas ligand , suggesting an activation of the apoptosis pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Platelet induced modulation of inflammation seems to involve platelet expression of ligands in the tumor necrosis factor ( TNF ) superfamily such as CD 40 ligand and Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ionizing radiation activates expression of FOXO3a , Fas ligand , and Bim , and induces cell apoptosis . ^^^ Ionizing radiation stimulates expression of apoptosis inducing proteins such as Fas ligand and the Bcl 2 interacting mediator of cell death ( Bim ) leading to cellular apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptotic endonuclease is a key enzyme that mediates regulated DNA fragmentation and chromatin condensation in response to apoptotic signals such as the Fas ligand , ionizing radiation , and anticancer agents . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fooling the Fas ligand in death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We previously reported that the proinflammatory cytokine IL 12 induced apoptosis in TNF alpha mediated osteoclastogenesis in mouse bone marrow culture through an interaction of Fas and Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The mammalian extrinsic apoptosis pathway is triggered by Fas ligand ( FasL ) and Apo 2 ligand / tumor necrosis factor ( TNF ) related apoptosis inducing ligand ( Apo2L / TRAIL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These CTL mediated major histocompatibility complex ( MHC ) class 1 restricted tumour cell lysis , production of interferon gamma ( IFN gamma ) and tumour necrosis factor alpha ( TNF alpha ) , and expression of Fas ligand ( FasL ) and TNF related apoptosis inducing ligand ( TRAIL ) in response to C 15 cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
STAT 1 alpha overexpression increased cell apoptosis and Fas ligand expression , compared with STAT 1 beta overexpression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The algorithm is applied to a signal transduction pathway of apoptosis induced by fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tumor necrosis factor apoptosis ligand ( TRAIL ) is a type 2 membrane bound ligand displaying expression in a broad range of tissues and exhibiting a high grade of homology with the cytotoxic Fas ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this study , we analyzed the effect of the HMG CoA reductase inhibitor simvastatin on disease manifestations in gld . apoE / mice that lack functional Fas ligand and apolipoprotein E and exhibit accelerated atherosclerosis and aggravated lupus like features . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Seasonal changes of proapoptotic soluble Fas ligand level in allergic rhinitis combined with asthma . ^^^ We measured serum levels of soluble Fas ( sFas ) and soluble Fas ligand ( sFasL ) , and examined whether there was any correlation between soluble apoptosis markers and development of asthma and or rhinitis in children with pollen allergy . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ex vivo soluble fas ligand treatment of donor cells to selectively reduce murine acute graft versus host disease . ^^^ Responder T lymphocytes were incubated ex vivo with irradiated allogenic stimulator cells in a mixed lymphocyte reaction ( MLR ) in the presence of soluble Fas ligand ( sFasL ) to induce AICD in alloreactive cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We have examined the contribution of perforin and Fas ligand to beta cell destruction using islet specific CD 8 ( + ) T cells from T cell receptor transgenic NOD8 . 3 mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In rat islets , constitutive expression of Fas ligand and glucose induced Fas receptor expression were observed only in 7 to 8 month old but not in 2 to 3 month old islets , whereas no age dependent changes in the Fas / Fas ligand system could be detected in human islets . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
After portal injection of irradiated B 6 C2D splenocytes into BALB / c mice , the host LSECs that endocytosed the irradiated allogeneic splenocytes showed enhanced expression of MHC class 2 molecules , CD 80 , and Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cytotoxicity is mediated by CTL granzyme and possibly death receptor ( DR ) ligand ( DR L ) , probably Fas ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ligand ( CD95L ) in primary malignant melanoma and melanoma metastases is associated with overall survival . ^^^ BACKGROUND : There is increasing evidence that the Fas / Fas ligand ( FasL ) system is involved in tumor mediated immune suppression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Despite their memory phenotype , intrahepatic T cells were defective in proliferation capability , produced less interferon gamma in response to stimulation by T cell receptor , and contained less perforin but expressed higher levels of Fas and Fas ligand , compared with their counterparts in peripheral blood . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Compared with healthy children , PKC activity was significantly enhanced in ITP children , increasing the expressions of Fas ligand on CD3+ , CD4+ and CD8+ T cells , indicating positive correlations between PKC activity and the expressions of Fas ligand on T cells , while the relations between PKC activity and platelet count showed negative correlations . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Plasma N terminal pro B type natriuretic peptide , tumor necrosis factor alpha , and soluble Fas ligand levels were significantly decreased only in the levosimendan group ( from 1 , 900 + / 223 to 1 , 378 + / 170 pg / ml , 13 . 4 + / 1 . 0 to 12 . 3 + / 1 . 2 pg / ml , and 68 . 2 + / 3 . 7 to 59 . 8 + / 3 . 6 pg / ml , respectively ; p < 0 . 05 for all ) ; interleukin 6 was also borderline reduced ( p = 0 . 051 ) . ^^^ Levosimendan induced reduction in end systolic wall stress was significantly correlated with respective decreases in N terminal pro B type natriuretic peptide ( r = 0 . 671 , p < 0 . 01 ) , tumor necrosis factor alpha ( r = 0 . 586 , p < 0 . 01 ) , soluble Fas ( r = 0 . 441 , p < 0 . 05 ) , and soluble Fas ligand ( r = 0 . 614 , p < 0 . 01 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
DATA SOURCES : A MEDLINE search for SJS and TEN in combination with Fas , Fas ligand ( FasL ) , cytotoxic T cells , intravenous immunoglobulin , and cyclosporine for articles published in English during 1966 to 2006 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Since the ligand for the death factor CD 95 ( CD95L ) was identified almost a decade ago , it has been established that this molecule ( CD95L , FasL , Apo 1L , CD 178 , TNFSF 6 , APT1LG1 ) has multiple immunoregulatory and pathophysiologically relevant functions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Genetic polymorphisms of Fas ( CD 95 ) and FasL ( CD 178 ) in human longevity : studies on centenarians . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Identification of interaction partners of the cytosolic polyproline region of CD 95 ligand ( CD 178 ) . ^^^ The CD95 / Fas / Apo 1 ligand ( CD95L , CD 178 ) induces apoptosis through the death receptor CD 95 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Similarly , B cells showed no change in the expression of class 2 major histocompatibility antigens , LFA 1 , ICAM 1 , CD 19 , CD 40 , CD 80 , CD 86 , CD 95 ( Fas ) , or CD 178 ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Serum concentrations of soluble CD 95 ( sCD 95 ) , soluble CD 95 ligand ( sCD95L ; CD 178 ) , tumour necrosis factor ( TNF ) alpha , soluble TNFalpha receptor type 1 ( sTNFR 1 ) , and interleukin 1beta converting enzyme ( ICE ; caspase 1 ) were measured by enzyme linked immunosorbent assay ( ELISA ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 178 ( Fas ligand / APO 1 ligand ) and CD 137 ligand ( CD137L ) , 2 molecules involved in the regulation of apoptosis , have previously been found in sera of patients with malignancies and have been hypothesized to participate in the pathogenesis of various diseases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Human autoimmune lymphoproliferative syndrome has been described as a result of various mutations concerning genes encoding receptor CD 95 and / or its ligand CD 178 . ^^^ However , recently , several cases with identical clinical manifestation , despite a normal structure of CD 95 or CD 178 have also been reported . ^^^ Using in vitro assays as well as molecular methods we tested expression and biological activity of CD 95 and CD 178 molecules . ^^^ This report confirms previous observations that lymphoproliferative disorder could be associated not only with CD 95 and / or CD 178 mutations , but also with dysfunction of other components of apoptosis induction pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Serum was collected for C reactive protein ( CRP ) detection ; flow cytometry with dual antibody staining was used to measure the apoptotic markers Fas ( CD 95 ) , FasL ( CD 178 ) and TNF R 2 ( CD120b ) in T cells ( CD3+ ) , B cells ( CD19+ ) , and monocytes ( CD14+ ) at 0 , 15 , 120 and 240 min after starting HD . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Study of Fas ( CD 95 ) and FasL ( CD 178 ) polymorphisms in liver transplant recipients . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TCAH attenuated AICD in CD4+ T cells by decreasing FasL ( CD 178 ) expression but not by altering Fas ( CD 95 ) expression or by interfering with Fas signaling events following direct engagement of the Fas receptor . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The CD 95 ( APO 1 / Fas ) ligand ( CD95L ) mediates apoptosis in sensitive target cells , Ca ( 2+ ) independent cytotoxicity of cells from perforin knock out mice , and peripheral deletion of activated T cells through engagement of its cognate receptor CD 95 . ^^^ CD 95 Fc receptor decoys , however , were effective in blocking apoptosis induced by mouse CD95L transfected L 929 cells in sensitive CD95+ target cells and in thymocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The CD 95 ligand ( CD95L ) is a member of the tumor necrosis factor family of cytokines and exists in a membrane bound and in a soluble form . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This effect is mediated by the CD 95 ( APO 1 / Fas ) receptor CD 95 ligand ( CD95L ) system and may be linked to the induction of oxidative stress by Tat . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To address the question of whether cytotoxic CD8+ T cells ( CTL ) activated in vivo are susceptible to cell death mediated by CD 95 ( Fas / Apo 1 ) ligand , a recombinant vaccinia virus expressing murine CD95L ( vacc CD95L ) was constructed , which drives CD95L expression to infected cells . ^^^ CD95L expression in vivo after infection with the vaccinia recombinant was sufficient to induce extensive necrosis in the liver of normal but not of CD 95 mutant lpr mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
As with T cell hybridomas , AID is dependent on both CD 95 and CD 95 ligand ( CD95L ) expression , but unlike hybridomas , the sensitive and resistant phenotypes of primary CD4+ cells can not be distinguished by levels of CD 95 expression , functional CD95L nor the fraction of cells in cycle . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We used human thymic tissue to perform in situ hybridization with a digoxigenin labeled CD 95 ( APO 1 / Fas ) ligand ( CD95L ) specific probe followed by TdT mediated biotin dUTP nick end labeling ( TUNEL ) of apoptotic DNA fragments . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis induced by gp 120 in the Th 1 clones is inhibited by either an anti CD 95 neutralizing MoAb or an anti CD95L neutralizing MoAb as well as by a specific interleukin 1 beta converting enzyme ( ICE ) inhibitor . ^^^ The CD95L produced by Th 1 clones induces cell death , inhibitable by anti CD 95 neutralizing MoAb , of CD 95 positive Jurkat cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Since CD 95 ligand ( CD95L ) is expressed on interleukin 2 ( IL 2 ) activated T cells , we investigated the involvement of CD 95 CD95L pathway in T cell mediated cytotoxicity against AML cells . ^^^ These findings suggest that T cell mediated cytotoxicity against AML cells requires participation of CD 95 CD95L pathway for cytotoxic signal transduction leading to target apoptosis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this study , we investigated the antitumor effect of locally produced CD 95 ligand ( CD95L ) on CD 95 negative tumor cells in vivo . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , bleomycin treatment of HepG 2 cells increased CD 95 ligand ( CD95L ) mRNA expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We also considered a new mechanism of immune evasion , namely , the active destruction of T lymphocytes by tumor cells expressing CD 95 ligand ( CD95L ) . ^^^ Our data suggest that tumor cells can evade immune attack by down regulation of the CD 95 receptor and killing of lymphocytes through expression of CD95L . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 ( APO 1 / Fas ) and CD 95 ligand ( CD95L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Wild type , perforin deficient , CD 95 mutant , CD95L mutant and perforin deficient / CD95L mutant mice were immunized with P . berghei irradiated sporozoites and submitted to a challenge with infectious sporozoites . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND & AIMS : Ligation of CD 95 ( APO 1 / Fas ) by antibody or CD 95 ligand ( CD95L ) induces apoptosis and , in some cell lines , growth . ^^^ Therefore , the CD 95 CD95L system is very unlikely to operate in the regeneration of the colonic epithelium . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
HIV gp 120 sensitizes Th 1 clones from seronegative donors to apoptosis , which occurs through two distinct events : expression of CD95L followed by its interaction with CD 95 to trigger cell death . gp 120 apoptosis of the Th 1 clone 103 was inhibited by Cyclosporin A , the PTK inhibitors Genistein and PNU 152518 , as well as the anti oxidants Ascorbic Acid and Glutathione . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD95L mRNA was constantly up regulated in T cells from patients in intermediate disease stages whereas patients with normal CD 4 counts and patients with advanced T cell loss showed CD 95 ligand mRNA levels in or slightly above the range of normal controls . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Both CD 95 ( APO 1 / Fas ) and CD95L ( APO 1 / Fas ligand ) became increasingly expressed during the course of activation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
T cell activation through the T cell receptor results in expression of the CD 95 ligand ( CD95L ) that acts on CD95+ cells by direct binding and in a paracrine or autocrine fashion . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : CD 95 and its ligand ( CD95L ) have been implicated in the regulation of immune responses . ^^^ METHODS : CD 95 negative cells ( baby hamster kidney and L5178Y lymphoma cells ) were transfected with CD95L cDNA to express functional CD95L . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 ( also termed Fas or APO 1 ) is a cell surface transmembrane receptor of the tumor necrosis factor receptor family that activates an intrinsic apoptotic suicide program in cells upon binding either its ligand CD95L or antibody . c myc induced apoptosis was shown to require interaction on the cell surface between CD 95 and its ligand . c Myc acts downstream of the CD 95 receptor by sensitizing cells to the CD 95 death signal . ^^^ CD 95 ( also termed Fas or APO 1 ) is a cell surface transmembrane receptor of the tumor necrosis factor receptor family that activates an intrinsic apoptotic suicide program in cells upon binding either its ligand CD95L or antibody . c myc induced apoptosis was shown to require interaction on the cell surface between CD 95 and its ligand . c Myc acts downstream of the CD 95 receptor by sensitizing cells to the CD 95 death signal . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ultraviolet light induces apoptosis via direct activation of CD 95 ( Fas / APO 1 ) independently of its ligand CD95L . ^^^ The human keratinocyte cell line HaCaT expresses CD 95 and undergoes apoptosis after treatment with UV light or with the ligand of CD 95 ( CD95L ) . ^^^ Incubation with a neutralizing CD 95 antibody completely prevented CD95L induced apoptosis but not UV induced apoptosis , initially suggesting that the CD 95 pathway may not be involved . ^^^ Since neutralizing anti CD 95 antibodies failed to prevent UV induced apoptosis , this suggested that UV light directly activates CD 95 independently of the ligand CD95L . ^^^ Confocal laser scanning microscopy showed that UV light induced clustering of CD 95 in the same fashion as CD95L . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The effect of lipopolysaccharide ( LPS ) on the expression of CD 95 ( APO 1 / Fas ) receptor and ligand ( CD95L ) was studied in primary cultures of rat liver Kupffer cells ( KCs ) , sinusoidal endothelial cells ( SECs ) , and parenchymal cells ( PCs ) at the messenger RNA ( mRNA ) level and by means of immunocytochemistry . ^^^ Apoptosis of PCs and thymic lymphocytes was stimulated by the addition of supernatants derived from LPS treated KC or SEC cultures and was apparently mediated by CD95L as assessed by its sensitivity to inhibitors of the CD 95 dependent apoptotic pathway in PCs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this study we investigated in NOD , non obese resistant ( NOR ) and Balb / c mice the expression of CD 95 and CD95L in alpha and beta pancreatic cells by immunohistochemistry and immunofluorescence . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 ( APO 1 / Fas ) is a cell surface receptor that , when oligomerized by natural ligand , CD95L , or antibody , confers an apoptotic signal to apoptosis sensitive cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The second , which requires binding of FasL ( CD95L ) on the effector cell with trimeric Fas ( CD 95 ) molecules on receptive target cells , is calcium independent and functions by generating a death signal at the inner leaflet of the target cell membrane . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the present study , we investigated the involvement of redox processes in the regulation of CD 95 ligand ( CD95L ) expression in Jurkat T cells . ^^^ Our data suggest that , although reactive oxygen intermediates do not act as mediators in the execution phase of CD 95 mediated apoptosis , they are involved in the transcriptional regulation of CD95L expression . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 ( Fas / APO 1 ) and its ligand ( CD95L ) belong to a growing cytokine and cytokine receptor family that includes nerve growth factor ( NGF ) and tumor necrosis factor ( TNF ) and their corresponding receptors . ^^^ Agonistic antibodies to CD 95 , or the natural ligand , CD95L , induce apoptosis in human malignant glioma cells in vitro . ^^^ For as yet unknown reasons , glioma cells may co express CD 95 and CD95L in vitro without undergoing suicide or fratricide . ^^^ Since CD95L is expressed in gliomas in vivo , too , forced induction of CD 95 expression might promote therapeutic apoptosis in these tumors . ^^^ Although several issues regarding glioma cell sensitivity to CD95L / CD95 mediated apoptosis await elucidation , CD 95 is a promising target for the treatment of malignant glioma . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recent data suggest that de novo expression of the CD 95 ligand ( CD95L ) in tumours might result in elimination of CD95+ anti tumour lymphocytes , and that tumours might therefore be privileged sites . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In patients , hepatic expression of CD 95 and CD95L mRNA and apoptosis were detected . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The CD 95 receptor is a death receptor capable of transducing apoptotic cell death upon ligation with the CD 95 ligand ( CD95L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The death signal of PCD occurs when the CD 95 receptor on the cell surface binds to the CD 95 ligand ( CD95L ) or to the anti CD 95 monoclonal antibody ( mAb ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here we provide a molecular explanation for this paradox : the engagement of the gammadelta TCR by mycobacterial antigens induced the expression of CD 95 ligand ( CD95L ) by chronically activated CD95+ / CD95L gammadelta T lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 ligand ( CD95L ) induced apoptosis is a novel immunotherapeutic approach to malignant glioma . ^^^ To confirm that changes in CD 95 expression are not required for the effects of IFN alpha , we show that IFN alpha enhances CD95L induced apoptosis even in CD 95 transfected LN 308 glioma cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 ( Fas ) and CD 95 ligand ( CD95L ( FasL ) ) were `` spontaneously ' ' expressed by B 16 cells growing in vitro in serum free medium ; these markers were strikingly up regulated by IFN gamma . ^^^ B 16 cells coexpressing CD 95 and CD95L were irreversibly programmed for apoptosis . ^^^ CD 95 ( Fas ) and CD 95 ligand ( CD95L ( FasL ) ) were `` spontaneously ' ' expressed by B 16 cells growing in vitro in serum free medium ; these markers were strikingly up regulated by IFN gamma . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We also show that resveratrol treatment enhances CD95L expression on HL 60 cells , as well as T47D breast carcinoma cells , and that resveratrol mediated cell death is specifically CD 95 signaling dependent . ^^^ On the contrary , resveratrol treatment of normal human peripheral blood lymphocytes ( PBLs ) does not affect cell survival for up to 72 hours , which correlates with the absence of a significant change in either CD 95 or CD95L expression on treated PBLs . ^^^ These data show specific involvement of the CD 95 CD95L system in the anti cancer activity of resveratrol and highlight the chemotherapeutic potential of this natural product , in addition to its recently reported chemopreventive activity . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 ligand ( CD95L ) is a cytotoxic cytokine that induces apoptosis in susceptible target cells . ^^^ Interestingly , medulloblastoma cells belong to an increasing number of tumor cell types that coexpress CD 95 and CD95L . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of the CD 95 ( APO 1 / Fas ) ligand ( CD95L ) in activated T cells is a major cause of T cell activation induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The object of this study was to examine whether cord blood mononuclear cells could behave either as targets for CD 95 mediated cell death or as mediators of cell death due to the expression of CD95L . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas ( CD 95 ) and FasL ( CD95L ) in human airway epithelium . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 ligand ( CD95L ) potently induces apoptosis by activating CD 95 on target cells . ^^^ It has recently been reported that melanoma cells in vivo express a significant amount of CD95L , thereby being immediately able to kill CD 95 bearing immunocompetent cells specific for cancer antigens , which infiltrate the lesions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Previous studies with CTL lines and CTL hybridomas have suggested that functional CD 95 ( APO 1 / Fas ) ligand ( CD95L ) expression on effector CTLs is a consequence of specific CTL target recognition and TCR triggering of newly transcribed CD95L . ^^^ PEL expressed functional CD95L , yet exhibited target cell specific killing , except when encountering high CD 95 expressing cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
B cells that chronically bind antigen due to prolonged antigen exposure , such as self reactive B cells , are induced to express CD 95 by CD 40 ligand ( CD40L ) and are subsequently eliminated by CD 95 ligand ( CD95L ) when they present antigen to CD4+ T cells . ^^^ B cells that bind antigen acutely due to sudden antigen encounter , such as foreign antigen reactive B cells , up regulate CD 95 , but are normally protected from CD95L mediated apoptosis . ^^^ The normal balance between T cell dependent humoral immunity and tolerance is thus regulated intrinsically by CD 95 expression on responding B cells , and extrinsically by CD 95 mediated control of CD95L or other molecules in the lymphoid micro environment . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis induced by CD 95 ligand ( CD95L ) did not involve NO formation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 ( Fas / APO 1 ) is a surface receptor that mediates apoptosis upon oligomerization by its ligand , CD95L . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Camptothecin , but not beta lapachone , synergistically enhanced RPE cell apoptosis induced by the cytotoxic cytokine , CD 95 ligand ( CD95L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Treatment with these cytotoxic drugs led to an upregulation of both , the CD 95 receptor ( CD 95 ) and the CD95L ( CD95L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Freshly isolated murine intestinal intraepithelial lymphocytes ( IEL ) express CD 95 ligand ( CD95L ) , as shown by reverse transcription polymerase chain reaction ( RT PCR ) and fluorescence activated cell sorter ( FACS ) analysis . ^^^ As a function , CD95L expressing IEL should be able to contribute to the elimination of CD 95 expressing target cells in the intestine . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 ligand ( CD95L ) in normal human lymphoid tissues : a subset of plasma cells are prominent producers of CD95L . ^^^ CD 95 ( Fas / APO 1 ) ligand ( CD95L ) mediates apoptosis by trimerization of the CD 95 receptor on the surface of sensitive cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Flow cytometric analysis showed that the surface expression of both CD 95 and CD 95 ligand ( CD95L ) was upregulated by endogenous Nef expression . ^^^ Nef mediated apoptosis was almost completely suppressed by the addition in culture of an anti CD 95 Fab ' IgG MoAb , which specifically blocks CD95 / CD95L interactions . ^^^ Lastly , mutation of a proline motif in the core region of the nef gene , which disrupts its ability to interact with cellular kinases and reduces HIV 1 replication in vitro , completely abrogated the Nef mediated induction of apoptosis as well as its ability to upregulate surface CD 95 and CD95L . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The CD 95 ( Fas ) / CD95 ligand ( CD95L ) system is an important mechanism triggering apoptosis , and CD95L expression has recently been implicated for immune evasion and aggressive behavior in malignancies . ^^^ This study aimed to investigate CD 95 and CD95L expression in lymphomas and the possible relationship with tumor cell apoptosis , with emphasis on the natural killer ( NK ) cell lymphomas , which are highly aggressive neoplasms and frequently exhibit tumor cell apoptosis / necrosis . ^^^ Frozen sections of 82 cases of lymphomas obtained from Queen Elizabeth Hospital and Caritas Medical Center , Hong Kong , were immunostained with polyclonal anti CD 95 and anti CD95L antibodies . ^^^ There was significant difference in the frequency of CD 95 expression between B and NK ( P < . 001 ) , and between T and NK cell lymphomas ( P < . 05 ) , and in CD95L expression between B and T ( P < . 01 ) or NK cell ( P < . 01 ) lymphomas . ^^^ Zonal tumor cell death was present in 21 ( 78 % ) NK cell lymphomas and 1 ( 4 . 5 % ) T cell lymphoma and showed no correlation with CD 95 or CD95L expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
AP 02 ligand ( APO2L ) is a CD 95 ligand ( CD95L ) related cytokine of the tumor necrosis factor family that interacts with agonistic ( DR 4 , DR 5 ) and antagonistic ( DcR 1 , DcR 2 ) receptors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 ( Apo 1 / Fas ) ligand ( CD95L ) expression has been observed in various malignancies . ^^^ In human primary cell lines from a squamous cell carcinoma ( SCC ) of the vulva , the effect of cisplatin ( CDDP ) and IFNgamma on the expression of CD95L and its 2 receptor isoforms , CD 95 transmembrane ( CD95tm ) and CD 95 soluble receptor , was studied at the mRNA and protein levels . ^^^ CD95L expressed by SCC cells was functionally relevant since these cells were able to induce CD 95 specific apoptosis in autologous lymphocytes from the SCC bearing patient . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The CD 95 ( APO 1 / Fas ) / CD95L system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Thus , LN 18 cells are highly sensitive to CD 95 ligand ( CD95L ) whereas LN 229 cells require coexposure to inhibitors of RNA or protein synthesis for induction of apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Two distinct forms of short term cytolysis have been described for CD8+ CTLs , the perforin / granzyme and Fas ligand / Fas ( CD 95 ligand ( CD95L ) / CD95 ) mediated pathways . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BAK and CD 95 expression in human malignant glioma cells but does not enhance CD95L induced apoptosis . ^^^ The temperature sensitive murine p53val135 mutant was introduced into 3 human malignant glioma cell lines to examine the effects of the p 53 status on BCL 2 family protein expression , CD 95 expression , and sensitivity to CD 95 ligand ( CD95L ) induced apoptosis . p53val135 behaves as a dominant negative mutant at 38 . 5 degrees C but assumes p 53 wild type properties . ^^^ Thus , wild type p 53 induces BAK and CD 95 expression in human glioma cells without enhancing their susceptibility to CD 95 mediated apoptosis , and mutant p 53 modulates CD95L evoked apoptotic signalling in a gain of function fashion up stream and down stream of caspase 3 activation . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
IAP proteins were not cleaved during CD 95 ligand ( CD95L ) induced apoptosis , and loss of IAP protein expression was not responsible for the potentiation of CD95L induced apoptosis when protein synthesis was inhibited . ^^^ LN 18 cells are highly sensitive to CD 95 mediated apoptosis , whereas LN 229 cells require co exposure to CD95L and a protein synthesis inhibitor , CHX , to acquire sensitivity to apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TGF beta and TNF alpha significantly reduced expression of CD95L in activated HSCs , whereas CD 95 expression remained unchanged . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Likewise , photoreactivating treatment did not affect apoptosis induced by the ligand of CD 95 , CD95L . ^^^ Inhibition of caspase 3 , a downstream protease in the CD 95 signaling pathway , blocked both CD95L and UVB induced apoptosis , whereas blockage of caspase 8 , the most proximal caspase , inhibited CD95L mediated apoptosis completely , but UVB induced apoptosis only partially . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NO left unaffected the expression of CD 95 and CD95L , suggesting interference with an event ensuing CD95 / CD95L interaction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To investigate abnormalities in the keratinization process in lesional epidermis of molluscum contagiosum , production of filaggrin , loricrin , Ted H 1 antigen , involucrin , cystatin A and CD 95 ligand ( CD95L ) was investigated using specific antibodies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We tested an unselected panel of 11 melanoma cell lines for sensitivity to CD 95 and the corresponding expression of CD 95 , CD95L , bcl 2 , bcl 10 , bcl xS , bax and FLIP proteins . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here we report that DCs that are transfected with CD 95 ligand ( CD95L ) cDNA , called ' killer ' DCs , deliver death signals , instead of activation signals , to T cells after antigen specific interaction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We describe induction of apoptosis by IFNgamma through the expression of CD 95 and its ligand ( CD95L ) in human neuroblastoma cell lines . ^^^ Neuroblastoma cells showed low constitutive expression of CD 95 and CD95L . ^^^ Subsequent to IFNgamma modulated increase in CD 95 and CD95L mRNA as well as protein levels , apoptosis was observed . ^^^ Our results demonstrated that cytokine mediated apoptosis was mediated through the activation of the CD95 / CD95L autocrine circuit since : ( 1 ) cell death occurred following CD95 / CD95L expression and correlated with CD 95 and CD95L expression levels , ( 2 ) failed to occur in a clone which weakly upregulated CD 95 and lacked CD95L induction after IFNgamma stimulation , ( 3 ) was at least partially inhibited by using blocking F ( ab ' ) 2 anti CD 95 antibody fragments and the recombinant Fas Fc protein , that prevented the interaction between CD 95 and CD95L . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Among the CD 34 ( ++ ) lin ( ) cells , both the freshly isolated CD38+ and CD 38 subsets as well as CD95+ and CD 95 cells constitutively expressed mCD95L , demonstrating that the CD95 / CD95L system represents a paracrine and potentially autocrine regulator of early hematopoiesis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Differential down regulation of CD 95 or CD95L in chronically HIV infected cells of monocytic or lymphocytic origin : cellular studies and molecular analysis by quantitative competitive RT PCR . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RESULTS : The HepG 2 cell expressing CD95L was able to kill the HepG2 . 2 . 15 cell with CD 95 expression , apoptotic rates were 16 . 5 % at 24 h and 43 . 0 % at 48 h incubation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here , we report that malignant glioma cells co express CD 95 and CD95L without undergoing suicidal or fratricidal apoptosis . ^^^ Although some cytotoxic drugs enhance the expression of CD 95 or CD95L , crm A fails to block drug induced cytotoxic and clonogenic cell death , suggesting that the drug induced changes in CD 95 and CD95L expression are epiphenomenal . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tu 2449 and SRB 10 cells that showed low CD 95 expression were resistant to CD 95 ligand ( CD95L ) induced apoptosis unless coexposed to CD95L and inhibitors of RNA or protein synthesis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 expression was constantly high , while CD95L showed a threefold increase in expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These data suggest that the gp 120 induced CD4 / CD95 association exerts a dual effect : an early effect that is independent of CD95L and may be due to direct triggering of CD 95 by gp 120 , and a late effect that may be due to sensitization of CD 95 to triggering by CD95L . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of the CD 95 ( APO 1 / Fas ) ligand ( CD95L ) in activated T cells is a major cause of activation induced T cell apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Studying the CD 95 ligand ( CD95L ) and receptor ( CD 95 ) system in eight non malignant mammary tissues and 40 breast cancer tissues , mRNA and protein expression was determined by quantitative reverse transcriptase polymerase chain reaction ( RT PCR ) and immunofluorescence . mRNA levels of CD95L correlated positively ( r=0 . 90 ; p < 0 . 01 ) and transmembrane CD 95 inversely ( r= 0 . 88 ; p < 0 . 01 ) with histopathological grading of the breast tumours : CD95L mRNA levels were low in adenomas , but increased by 20 fold in grade 1 , 120 fold in grade 2 , and 310 fold in grade 3 breast cancer . ^^^ Since CD95L acts as an efficient inducer of apoptosis in CD 95 ( + ) cells , apoptotic cells were identified on the tissue sections . ^^^ The target cells underwent apoptosis when cultured on breast cancer sections , but could be rescued when CD95L was specifically blocked by a CD 95 Fc fusion molecule . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although glioma cells undergo apoptosis when exposed to the death ligand , CD 95 ( Fas / APO 1 ) ligand , the therapeutic use of CD95L is considered impossible because of lethal side effects . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Using superantigen activated human T cells , we found that whilst T cell receptor ( TCR ) signalling triggered up regulation of CD 95 ligand ( CD95L ) , the majority of T cells were resistant to apoptosis induction , despite co expressing high levels of CD 95 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activation induced cell death ( AICD ) in T cells is mediated by CD 95 ligand ( CD95L ) / receptor interaction , which has also been implicated in apoptosis induction by some anticancer agents . ^^^ CD95L expressing H 9 cells killed CD 95 sensitive J 16 or CEM target cells , but not CD 95 resistant CEM or J 16 cells overexpressing dominant negative FADD ( J16 / FADD DN ) . ^^^ By immunoprecipitation , CD95L was physically bound to CD 95 , suggesting that AICD and doxorubicin induced apoptosis involve CD95L mediated CD 95 aggregation , thereby triggering the CD 95 death pathway . ^^^ Blocking of the CD95L / receptor interaction by antagonistic antibodies to CD 95 or to CD95L also blocked AICD and inhibited the early phase of doxorubicin induced apoptosis , though cell death induced by doxorubicin eventually proceeded in a CD 95 independent manner . ^^^ Thus , in cells with an inducible CD 95 receptor / ligand system , drug induced apoptosis may be mediated by CD95L initiated DISC formation and activation of downstream effector programs similar to AICD in T cells . ( Blood . 2000 ; 95 : 301 308 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It is very well known that the extracellular region of the CD 95 receptor is required for CD95L interaction and that the death domain is necessary for the induction of the apoptotic signaling . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cartilage hair hypoplasia syndrome : increased apoptosis of T lymphocytes is associated with altered expression of Fas ( CD 95 ) , FasL ( CD95L ) , IAP , Bax , and Bcl 2 . ^^^ Increased apoptosis in CHH was associated with increased expression of Fas ( CD 95 ) , CD95L , and Bax and decreased expression of Bcl 2 and inhibitor of apoptosis protein ( IAP ) compared to the control . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interaction of CD 95 ( Apo 1 / Fas ) and its ligand ( CD95L ) plays an important role in the regulation of the immune response , since CD95+ lymphocytes may be killed after engagement of the CD 95 receptor . ^^^ Studying the CD95 / CD95L system in 40 cases of breast cancer , the malignant cells expressed CD95L , but lost CD 95 expression , when compared with non malignant mammary tissue . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cultivated H RS cells are resistant to CD95L mediated apoptosis despite expression of wild type CD 95 . ^^^ MATERIALS AND METHODS : Two B cellular H RS cell lines ( L 1236 and L 428 ) were used to test for the expression of CD 95 by flow cytometry and for the induction of apoptosis after incubation with CD95L obtained from retrovirally transduced murine myoblasts . ^^^ CONCLUSIONS : Our results indicate that the two H RS cell lines L 1236 and L 428 are resistant to CD 95 mediated apoptosis induced via CD95L , although wild type CD 95 is expressed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD95L , CD 95 , apoptosis induced cysteine protease CPP 32 , apoptosis promoting protein Bax , and proliferating marker ( MIB 1 ) frequently were positive in the lymphoma cells of cases with angiodestruction , but there was no expression of apoptosis inhibitor protein Bcl 2 . ^^^ In most cases without angiodestruction , lymphoma cells were positive for CD95L and Bax and negative for CD 95 , CPP 32 , and MIB 1 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 ( APO 1 / Fas ) ligand ( CD95L ) gene expression is critically involved in activation induced T cell apoptosis . ^^^ CD 95 ( APO 1 / Fas ) ligand ( CD95L ) gene expression is critically involved in activation induced T cell apoptosis . ^^^ We and other have previously shown that HIV 1 Tat which is essential for efficient HIV gene expression sensitizes CD 95 mediated apoptosis and up regulates CD95L expression in T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 and CD 95 ligand ( CD95L ) are physiological mediators of apoptosis required for the control of cell numbers in the human immune system . ^^^ Clonal contraction of lymphocytes by a CD95 / CD95L independent mechanism has been reported and new evidence supports a role for CD 95 dependent peripheral lymphocyte deletion by non lymphoid tissue . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Administration of a LacZ expressing adenoviral vector induces NFkB DNA and correlates with the up regulation of Fas ( CD 95 ) mRNA , but not FasL ( CD95L ) mRNA , during the early phase of adenoviral hepatitis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : LN 18 , LN 229 and T98G human malignant glioma cell lines were irradiated with dosages from 0 8 Gy and treated with CD95L ( CD 95 ligand ) . ^^^ RESULTS : We find that ( 1 ) CD95L induced apoptosis , but not irradiation induced clonogenic cell death , involves caspase 3 activation and is blocked by the viral caspase inhibitor , crm A . ( 2 ) Irradiation does not modulate CD 95 expression either in p 53 wild type or in p 53 mutant glioma cell lines , and does not enhance CD95L evoked caspase 3 activity or CD95L induced clonogenic cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Stimulation of T cells with DCs at an S / R ratio of 5 induced a higher level of expression of CD 95 ligand ( CD95L ) than stimulation of T cells cultured with DCs at an S / R ratio of 0 . 5 , whereas similar levels of expression of CD 28 and CD 154 were observed in both cells . ^^^ The abortive proliferation of mature T cells stimulated with DCs was prevented by blocking the CD 95 CD95L system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Taken together , the upregulated expression of CD 95 , and the presence of CD95L in the close proximity to apoptotic gastric epithelial cells suggest a functional role of the CD 95 CD95L system in the induction of apoptosis in H . pylori gastritis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : Pure cultured I / CB PE cells were obtained from eyes of normal and CD 95 ligand ( CD95L ) deficient mice and tested for their capacity to suppress T cell activation in three different T cell receptor ( Tcr ) ligand systems : mixed lymphocyte reactions , stimulation of Tcr transgenic T cells ( D011 . 10 ) by specific antigen ( ovalbumin ) , and ligation of the Tcr associated CD 3 molecule by anti CD 3 antibodies . ^^^ Cultured I / CB PE cells expressed mRNA for TGF beta 1 , TGF beta 2 , IL 6 , IL 10 , and TNF alpha , but not IL 4 , IFN gamma , proopiomelanocortin ( POMC ) , and CD95L ( Fas L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The results indicate that when ACAID was induced by in vitro generated ACAID inducing cells , the APC expressed CD95L , and recipient T cells expressed CD 95 . ^^^ The capacity of in vitro generated regulatory T cells to suppress DH expression to OVA in vivo was not governed by CD 95 CD95L interactions . ^^^ When OVA was injected into the anterior chamber of naive mice , CD 95 expression was required for ACAID induction , although ACAID was readily induced in CD95L deficient mice . ^^^ We conclude that CD 95 CD95L interactions are required in ACAID for the initial stage of APC presentation of eye derived antigens to T cells , and that CD 95 CD95L interactions participate at one or more additional step in the process by which ACAID is induced by soluble protein antigens . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cultivated H RS cells are resistant to CD95L mediated apoptosis despite expression of wild type CD 95 . ^^^ Therefore , two B cellular H RS cell lines ( L 1236 and L 428 ) were used to test for the expression of CD 95 by flow cytometry and for the induction of apoptosis after incubation with CD95L obtained from retrovirally transduced murine myoblasts . ^^^ CONCLUSIONS : Our results indicate that the two H RS cell lines L 1236 and L 428 are resistant to CD 95 mediated apoptosis induced via CD95L , although wild type CD 95 is expressed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this study , we evaluate the effects of IL 4 in Fas ( CD 95 ) / FasL ( CD95L ) mediated killing of Fas overexpressing target cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tgf beta 1 , Tgf beta RIII , CD 95 , and CD95L mRNA levels underwent slight or no changes in any tissue + / AMPH . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
B cell apoptosis in the central nervous system in experimental autoimmune encephalomyelitis : roles of B cell CD 95 , CD95L and Bcl 2 expression . ^^^ Three colour flow cytometry indicated that B cells expressing CD 95 ( Fas ) or CD 95 ligand ( CD95L ) were highly vulnerable to apoptosis , whereas B cells expressing Bcl 2 were relatively protected from apoptosis . ^^^ We propose that B cells are eliminated from the CNS by the interaction of CD95L and CD 95 on the same B cell and that this contributes to the spontaneous resolution of CNS inflammation and clinical recovery in acute EAE . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : Cell culture and cytotoxicity assays based upon 51Cr release and flow cytometry were used to evaluate cell killing via CD 95 molecule , flow cytometry to assess surface antigens , enzyme linked immunosorbent assay ( ELISA ) for the determination of soluble CD 95 and CD95L plasma levels , quantitative competitive ( QC ) reverse transcription polymerase chain reaction ( RT PCR ) with an original RNA competitor for the analysis of CD95L mRNA expression and QC RT PCR for determining plasma viral load . ^^^ Activation of CD 95 on the surface of isolated lymphocytes by anti CD 95 monoclonal antibodies or binding to CD95L induced rapid apoptosis . ^^^ The hypothesis can be put forward that a complex balance exists between proapoptotic events ( increase in CD 95 expression ) , probably triggered by the host as a method to limit viral production , and antiapoptotic events ( decrease in CD95L expression ) probably triggered by the virus as a way to increase its production and survival . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunohistochemical analysis of CD 30 positive lymphoproliferative disorders for expression of CD 95 and CD95L . ^^^ Paraffin embedded , formalin fixed tissue sections from 25 cases of CD 30 positive LPDs ( 10 noncutaneous ALCL , 15 PC CD 30 positive LPDs ) were immunostained for CD 3 , CD 20 ( L 26 ) , CD 43 ( Leu 22 ) , CD 30 ( BerH 2 ) , anaplastic lymphoma kinase ( ALK 1 ) , CD 95 , and CD95L ( C 33 ) . ^^^ Expression of CD 95 in the small lymphocytes and CD95L in the large atypical cells was not significantly different . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 ( Fas / APO 1 ) is a member of the TNFR superfamily that induces apoptosis following cross linking with its cognate ligand , CD95L ( FasL / APO 1L ) or agonist antibody . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : Two color cytometric analysis was used to study the phenotype of freshly separated mononuclear cells , while Western blotting was used to detect CD 95 ligand ( CD95L ) expression in total homogenates of isolated CD4+ T lymphocytes . ^^^ A positive correlation was found between the activity of disease , the decrease in the CD4+ T cell number , and the increase in the expression of CD 95 , CD95L , HLA DR , and CD45RO molecules within the CD4+ T cell subset . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We report here that the progression of pancreatic carcinomas in tumor patients is associated with increased serum levels of both the soluble forms of CD 95 ligand ( CD95L / FasL ) and its receptor , CD 95 ( Fas ) . ^^^ Because the secreted forms of both CD 95 and CD95L have been implicated previously in protection of cells from CD 95 mediated cell death , we assessed the effect of soluble CD95L in supernatants of pancreatic carcinoma cells on viability of Jurkat T lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Retinoids do not modulate CD 95 or CD95L expression or susceptibility to CD 95 mediated apoptosis and fail to act in synergy with interferon ( IFN ) alpha or IFN gamma or cancer chemotherapy drugs to promote growth inhibition or apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In 21 patients with lymphoproliferative disease of granular lymphocytes ( LDGL ) , we investigated the expression and the function of molecules belonging to TNF receptor and TNF ligand superfamilies ( CD30 / CD30L ; CD40 / CD40L ; CD27 / CD70 ; Fas [ CD 95 ] / FasL [ CD95L ] ) . ^^^ On functional grounds , a stimulatory activity on rIL 2 mediated redirected cytotoxicity against Fcgamma+ P 815 targets was demonstrated with anti CD 30 , CD 40 , CD40L , CD 70 , CD 95 , and CD95L mAbs , although resting cells were unable to exhibit significant redirected cell lysis . ^^^ The addition of anti CD 30 , CD30L , CD 40 , CD40L , CD 95 , and CD95L mAbs did not show any significant effect on cell proliferation at resting conditions or after rIL 2 stimulation , whereas anti CD 70 mAb mediated cell proliferation in 6 of 10 cases tested . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
T cell apoptosis and AICD are controlled by survival cytokines such as interleukin 2 ( IL 2 ) and by death factors such as tumor necrosis factor ( TNF ) and CD 95 ligand ( CD95L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , sFRPs do not modulate glioma cell susceptibility to apoptosis induced by the cytotoxic cytokines , CD 95 ( Fas / APO 1 ) ligand ( CD95L ) or Apo 2 ligand / tumor necrosis factor related apoptosis inducing ligand ( Apo2L / TRAIL ) , or various cytotoxic drugs . sFRP 2 strongly promotes the growth of intracranial glioma xenografts in nude mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition to CD 95 , its natural ligand ( CD95L ) is also implicated in malignant progression . ^^^ On this basis , the significance of loss of CD 95 and gain of CD95L expression for tumor progression is discussed . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To evaluate the role of death ligands in elimination of DCs , we analyzed the sensitivity of human DCs to CD 95 ligand ( CD95L ) and tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Hepatocytes constitutively express CD 95 ( also called Fas / APO 1 ) and are therefore potential targets for CD 95 ligand ( CD95L ) mediated injury . ^^^ We conclude that coculture of mouse hepatocytes with F ( CD95L+ ) is a useful in vitro model for CD 95 mediated apoptosis induced by CD95L . ^^^ These changes were observed only when normal hepatocytes were cocultured with F ( CD95L+ ) and were not observed with F ( CD95L ) or in hepatocytes from Fas ( lpr ) mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here we report that the CD 95 ligand ( CD95L ) is upregulated in hepatoma cells upon treatment with antineoplastic drugs . ^^^ Thus , understanding the mechanisms of CD 95 mediated apoptosis through CD95L upregulation upon treatment of hepatocellular carcinomas with chemotherapeutic drugs may contribute to the improvement of anticancer chemotherapy . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although full class 2 mediated killing required DC cytoskeletal motion , divalent cations and phosphatase activity , neither caspase activation , respiration , RNA or protein synthesis , NO production , nor CD 95 : CD95L interactions were required . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Chronic lymphocytic leukemia B cells inhibit spontaneous Ig production by autologous bone marrow cells : role of CD 95 CD95L interaction . ^^^ However , the addition of monoclonal antibody that blocked the function of either CD 95 or CD95L clearly reversed B CLL cell inhibition on autologous BM plasma cells . ^^^ These latter cells were shown to express CD 95 , and B CLL cells contained detectable quantities of CD95L at the level of messenger RNA and protein . ^^^ Collectively , these data suggest that B CLL cells inhibit autologous CD 95 bearing Ig secreting cells by the interaction with CD95L present on B CLL cells and , hence , contribute to the state of humoral immunodeficiency that occurs in these patients . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Blockade of the release of soluble tumor necrosis factor alpha ( TNF alpha ) and CD 95 ligand ( CD95L ; FasL ) from cell associated forms is reportedly involved in the mechanism of the drug effect . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We report in this work that injection of adenovirus expressing the human wild type p 53 gene ( Ad5CMVp53 ) into established human colorectal tumors in nu / nu mice resulted in CD 95 ligand ( CD95L ) overexpression , followed by a massive neutrophil infiltration . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
AICD is mediated predominantly by CD 95 ( APO 1 / Fas ) and its cognate ligand ( CD95L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Several proteins are rapidly tyrosine phosphorylated ; erk and c jun are strongly activated ; expression of CD 69 and CD 25 is up regulated on mature T cells ; and expression of CD 95 and CD95L is up regulated on the T helper line . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression and signalling by Fas and its ligand ( FasL , CD95L ) is a tightly regulated process essential for key physiological functions in a variety of organs , including the maintenance of immune homoeostasis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Moreover , blocking CD 95 CD95L interactions with antagonistic CD 95 monoclonal antibody did not prevent drug induced apoptosis . ^^^ In summary , these results suggest that apoptosis induced by thymineless stress in haematopoietic BA / F3 cells occurs by a mechanism that does not require accumulation of p 53 and which is independent of CD 95 CD95L interactions . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
When screening four human melanoma cell lines for expression of CD 95 and CD 95 ligand , respectively , an inverse correlation was found , i . e . , cells expressing high levels for CD 95 ligand ( CD95L ( high ) ) were almost negative for CD 95 and vice versa . ^^^ Since coexpression of CD 95 and CD 95 ligand may lead to apoptosis by autocrine suicide or fratricide , it was tested whether overexpression of CD 95 in CD95L ( high ) melanoma cells results in apoptotic cell death . ^^^ Upon transfection with a cytomegalovirus promoter driven expression vector encoding the CD 95 gene , CD95L ( high ) melanoma cells underwent apoptosis at a much higher level than CD95L ( low ) melanoma cells . ^^^ Tumor progression of CD95L ( high ) melanoma cells transplanted into nude mice was significantly reduced when recipient animals were injected with liposomes containing the CD 95 expression vector . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Using an established SIV / HIV C2 / 1 infected cynomolgus monkey model displaying stable CD4+ T cell depletion , the kinetics of apoptosis and the levels of expression of CD 95 membrane associated CD95L on lymphocytes were investigated to test the involvement of the CD95 / CD95L system in CD4+ T lymphocyte loss in vivo . ^^^ Since CD95L was expressed on CD8+ T cells , B cells and to a lesser extent on CD4+ T cells , this suggests that CD 95 mediated apoptosis might be controlled in an autocrine / paracrine fashion . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 and CD 95 ligand ( CD95L ) were up regulated in a dose and time dependent manner on the cell membrane and also released after treatment with GC . ^^^ In contrast , the caspase inhibitor N : acetyl Asp Glu Val Asp aldehyde suppressed caspase 3 activation and apoptosis , but did not down regulate caspase 8 activation and expression of CD 95 and CD95L . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It was the aim of our study to determine which genomic alterations in malignant gliomas modulate the sensitivity to chemotherapy or cytotoxic cytokines such as CD 95 ligand ( CD95L ) or Apo2L / tumor necrosis factor related apoptosis inducing ligand ( Apo2L / TRAIL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In order to determine the role of CD 95 in mediating apoptosis of antigen specific lymphocytes in tuberculosis , mice with a mutated CD95L molecule were infected systemically with virulent Mycobacterium tuberculosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Quantitation of CD 95 and CD95L mRNA expression in chronic and acute HIV 1 infection by competitive RT PCR . ^^^ In immune cells the oligomerization of CD 95 , induced by its ligand CD95L , and the recruitment of different intracytoplasmic molecules that in turn activate FLICE / caspase 8 are crucial . ^^^ To study the role of CD95 / CD95L interactions during HIV 1 infection , we developed an original method based upon quantitative competitive ( QC ) RT PCR that allowed us to quantify the amounts of mRNA coding for the total ( tCD 95 ) and membrane ( mCD 95 ) forms of CD 95 . ^^^ We have shown that infected cells of monocytic origin preferentially produce the `` protective ' ' ( soluble ) form of CD 95 , and no detectable CD95L mRNA , while lymphoid cells produce more mRNA for the membrane form of CD 95 ( which triggers apoptosis ) along with low but detectable amounts of CD95L mRNA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 ( APO / Fas ) ligand ( CD95L ) is a member of the TNF family predominantly expressed by activated T and NK cells but also by tumors of diverse cellular origin . ^^^ CD95L trimerizes surface CD 95 expressed by target cells that subsequently undergo apoptosis . ^^^ L 1210 Fas antisense expressing K ( b ) , crmA , and CD95L ( LKC CD95L ) killed CD 95 ( + ) unrelated tumor targets and Con A activated splenocytes from anti K ( b ) TCR tg PKO mice by a CD95L dependent mechanism in vitro . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Later , analysis of altered sensitivity to CD 95 induced apoptosis in cells targeted by the immune response has revealed an unexpected role for CD 95 and CD95L in organ specific autoimmunity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although caspase 3 and 8 activation was detected in immature DC undergoing CD95L induced apoptosis , the pan caspase inhibitor zVAD fmk did not inhibit the early events of CD 95 induced mitochondrial depolarisation or phosphatidyl serine exposure and only partially inhibited the killing of immature DC . ^^^ Collectively , these data do not support a major role of CD 95 : CD95L ligation in apoptosis of mature DC , but rather emphasise the existence of distinct pathways for the elimination of DC at different stages of maturation . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Decoy receptor 3 ( DcR 3 ) is a newly identified soluble protein that binds to CD 95 ligand ( CD95L ) and inhibits its proapoptotic activity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Surprisingly , at four different time points no difference in levels of T cell apoptosis in the spleen and liver was found between these mice and controls following intravenous delivery of L . donovani amastigotes , indicating that the CD 95 / CD95L interaction is not essential for T cell apoptosis in the L . donovani infected liver and spleen . ^^^ These results indicate important roles for CD 95 and CD95L that are unrelated to regulation of apoptosis in the early control of L . donovani infection . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Our data showed that Dex , in a dose dependent manner , down regulated surface expression of CD 86 , CD 40 , CD 54 and MHC class 2 molecules by DC , but the expression of MHC class 1 , CD 80 , CD 95 and CD95L were not affected . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD4+Th1 cytotoxic T cells induce apoptosis of their targets via oligomerizing CD 95 ( APO 1 / Fas ) death receptors on target cells by their CD 95 ligand ( CD95L ) . ^^^ We determined the expression of CD 95 and CD95L in epithelia of normal and chronically inflamed pancreatic tissues . ^^^ We applied RT PCR and Western blotting for CD95L expression profiles , serial frozen section immunohistochemistry to detect CD 95 , CD95L , and HLA DR molecules , CD 3 , CD 4 , CD11c , and S 100 protein ( S100p ) . ^^^ Immunohistochemistry revealed a mutually exclusive expression of CD 95 and CD95L . ^^^ Physiologically , acini were CD 95 / CD95L+ , ducts were CD 95 / CD95L , and islets were CD 95 / CD95L+ . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Therefore , the effect of IFN alpha on CD 95 CD95L expression , on the release of TNF alpha , and on TNF receptor 1 expression in an IFN sensitive human Burkitt lymphoma cell line ( Daudi ) was investigated . ^^^ Although supernatants of IFN treated Daudi cells induced apoptosis of CD 95 sensitive Jurkat cells , CD95L was undetectable on protein or on messenger RNA levels , and the weak initial expression of TNF receptor 1 increased only slightly during IFN treatment . ^^^ Surprisingly , binding of TNF alpha to CD 95 was observed and confirmed by 3 different techniques enzyme linked immunosorbent assay using immobilized CD 95 : Fc immunoglobulin G , immunoprecipitation assay using CD 95 receptor precipitates of Daudi cells , and binding of sodium iodide 125 TNF alpha to Daudi cells , which was strongly stimulated by IFN alpha and inhibited by CD95L , CD 95 : Fc , unlabeled TNF alpha , and anti TNF alpha antibody . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here , we report that adenoviral ( Ad ) TK / GCV induced death is p 53 independent and does not involve altered CD 95 or CD95L expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 ligand ( CD95L ) immunohistochemistry : a critical study on 12 antibodies . ^^^ In recent years , some studies on the expression of CD 95 ( Fas / APO 1 ) ligand ( CD95L ) in tissues or cells raised concerns about the specificity of the antibodies used . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In murine models of autoimmune lupus , mutations in cell death receptor CD 95 ( Fas ) and its ligand CD95L ( FasL ) have been identified ; these errors create a lymphoid system resistant to apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
After autoimmune inflammation , interactions between CD 95 and its ligand ( CD95L ) mediate thyrocyte destruction in Hashimoto ' s thyroiditis ( HT ) . ^^^ We found that GD thyrocytes expressed CD 95 and CD95L in a similar manner to HT thyrocytes , but did not undergo CD 95 induced apoptosis either in vivo or in vitro . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recent evidence indicates that pancreatic cancer cells express CD95R and CD95L but are insensitive to CD 95 mediated apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cross linking of CD 95 enhanced AP 1 DNA binding activity and AP 1 dependent CD95L transactivation , which were both significantly reduced by different NO donors compounds . ^^^ However , AP 1 induction does not seem to significantly contribute to anti CD 95 triggered apoptosis , as cell death could not be prevented by using the recombinant Fas Fc fusion protein which inhibits the CD95 / CD95L interaction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this study we analyzed the in vitro consequences of an interaction of human T cells with allogeneic 293 cells and 293 transfectants stably expressing high levels of the apoptosis inducing CD 95 ligand ( CD95L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Additional results strongly suggested that the CD 95 ligand ( CD95L ) was a major cause of neuronal autocrine suicide in the penumbra . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Death ligands such as CD 95 ligand ( CD95L ) or tumor necrosis factor related apoptosis inducing ligand / Apo2 ligand ( TRAIL / Apo2L ) induce apoptosis in radiochemotherapy resistant human malignant glioma cell lines . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To evaluate a possible role of the CD95 / CD95L system in human neuroblastoma ( NB ) cells , we investigated the constitutive and interferongamma ( INFgamma ) induced expression of CD 95 and CD95L , and CD 95 mediated cell death in the SK N BE ( 2 ) cell line . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These results demonstrated that CD137L costimulation induces a rapid induction of CD95L on CD4+ T cells and leads to apoptosis of CD 95 sensitive target cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TNF alpha ( 200 ng / ml ) or actinomycin D ( ActD ) ( 5 ng / ml ) did not kill cells , while 5 ng / ml of TNF alpha and 5 ng / ml of ActD increased expression of Fas ( CD 95 ) and FasL ( CD95L ) , and 45 % of cells died . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 ligand ( CD95L ) induced mitochondrial cytochrome c release and processing of caspases 3 , 7 , 8 and 9 in LN 18 cells in the absence of an inhibitor of protein synthesis , cycloheximide ( CHX ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Most human malignant glioma cell lines are susceptible to CD 95 ligand ( CD95L ) induced apoptosis . ^^^ Gene transfer mediated enhancement of CD 95 expression results not only in increased susceptibility to CD95L , but also in increased sensitivity to C 2 ceramide . ^^^ We conclude that ( 1 ) synergistic induction of apoptosis by C 2 ceramide and CD95L depend on a cross talk between the two signal transduction pathways and that ( 2 ) C 2 ceramide , independently of its sensitizing effects on CD 95 dependent caspase activation , is also capable of triggering an apoptotic signaling cascade that is unaffected by zVAD fmk mediated caspase inhibition , but promoted by high levels of CD 95 expression . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interestingly , ectopic expression of APRIL confers minor protection from apoptotic cell death induced by the death ligands , CD 95 ligand ( CD95L ) and tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) / Apo2 ligand ( Apo2L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ex vivo pediatric brain tumors express Fas ( CD 95 ) and FasL ( CD95L ) and are resistant to apoptosis induction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Analysis of the 10 % survivors of a LD ( 90 ) dose of CD 95 ligand ( CD95L ) at 24 h demonstrated them to arise preferentially from the S + G2 / M phases of the cell cycle and to remain clustered in S + G2 / M without undergoing cell division . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We demonstrate that induction of apoptosis in DU 145 cells , upon exposure to 9NC , is associated with de novo expression of CD 95 and CD95L , suggesting that 9NC induced apoptosis is mediated by the CD 95 system . ^^^ We propose that 9NC triggers apoptosis by driving DU 145 cells from a nonapoptotic status ( c FLIP ( short ) ( high ) , CD 95 ( low ) , CD95L ( low ) ) toward a proapoptotic status ( c FLIP ( short ) ( low ) , CD 95 ( high ) , CD95L ( high ) ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This may result from the ligation of T cell death receptors ( such as CD 95 ( Fas ) or tumor necrosis factor ( TNF ) receptor 1 ) by CD 95 ligand ( CD95L ) or TNF expressed by the same T cell or possibly by microglia , astrocytes or neurons . ^^^ T cells expressing CD 95 may also die in an antigen nonspecific manner after interacting with glial cells expressing CD95L . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
There is an increasing amount of evidence that melanoma cells express the ligand for CD 95 ( CD95L ) , a potent inducer of apoptosis which contributes to creating the immune privileged circumstances of tumor sites . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Type 1 and type 2 subsets were also found to be differentially susceptible to CD 95 mediated apoptosis , although cell surface expression of CD 95 and CD95L was at similar levels on all subsets . ^^^ A role for CD 95 in AICD was confirmed by the addition of anti CD95L antibodies that partially abrogated AICD . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
WEHI 279 cells express CD 95 and undergo apoptosis after treatment with either an agonistic anti CD 95 Ab or with a soluble recombinant CD95L . ^^^ However , incubation with CD 95 Fc or TRAIL R 1 Fc fusion proteins , did not prevent IFN gamma mediated apoptosis , suggesting that IFN gamma mediated apoptosis occurs independently of CD95 / CD95L and TRAIL R / TRAIL interactions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We found that the liver cells do express CD 95 ligand ( CD95L ) , a cytotoxic cell surface molecule . ^^^ METHODS : The HepG 2 cells with induced CD95L and the HepG2 . 2 . 15 cells with constitutive CD 95 expression were coincubated . ^^^ RESULTS : In chronic hepatitis B intrahepatic expressions of CD95L and / or CD 95 were detected at both mRNA and protein level . ^^^ The HepG 2 cells with CD95L could kill the HepG2 . 2 . 15 cells with CD 95 molecule with apoptotic rates of 16 . 5 % at 24h and 43 . 0 % at 48h . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ligation of CD 95 by CD95L expressed on anergic T cells in the absence of CD 40 CD40L ( CD 154 ) interaction are critical parameters in eliciting apoptosis in both DC and responder T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The CD 95 ligand ( CD95L ) is induced in response to a variety of signals , including IFN gamma and TCR / CD3 stimulation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Photoactivation of HA and HB enhanced both CD95 / CD95L expression and induced CD 95 signaling dependent cell death in all tumor cell lines studied . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , rifampicin down regulated the expression of Bax and CD95L and up regulated the expression of Bcl 2 , Bcl xL , and Flice inhibitory protein L ( FLIPL ) ; however , rifampicin had no effect on CD 95 or XIAP expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Similar to CD 95 ligand ( CD95L ) , TRAIL signaling requires ligand receptor interaction ; the downstream signaling molecules , such as Fas associated death domain and caspase 8 , also seem similar . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We have shown that in untreated patients , BCC cells constitutively express CD 95 ligand ( CD95L ) , but not the receptor . ^^^ In IFN alpha treated patients BCC cells express not only CD95L but also CD 95 receptor , and regress by committing suicide or fratricide through apoptosis induction via CD 95 receptor CD95L interaction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Indeed , the death ligand CD95L ( FasL , APO 1 L ) is constitutively found on neurons , microglia and astrocytes . ^^^ T cells also express CD95L and TNF related apoptosis inducing ligand ( TRAIL ) , and the presence of CD 95 ( Fas , APOI ) and TRAIL receptors renders brain cells putative targets of T cell induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Vpr induced signaling pathway did not induce CD 95 or CD95L expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Doxorubicin induced apoptosis was preceded by up regulation of CD 95 and CD95L and a collapse of mitochondrial membrane potential ( Deltapsi ) occurring prior to phosphatidylserine externalization . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Characterization of CD 95 ligand ( CD95L ) induced apoptosis in human tenon fibroblasts . ^^^ Immunohistochemistry and Western blot were used to investigate the CD 95 and CD95L expression . ^^^ Tenon and NIH 3T3 fibroblasts express CD 95 and CD95L . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This phenomenon is mediated by the interaction of CD95L molecules expressed by B CLL cells with the death receptor CD 95 that is up regulated on patients ' PC , leading to PC apoptosis and subsequently to hypogammaglobulinemia . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In vitro , cortical neuroblast cells are susceptible to CD 95 ligand ( CD95L , FasL , APO 1 L ) induced apoptosis . ^^^ Comparison of neuronal density and subfield sizes in the hippocampus of CD95L deficient ( gld ) , CD 95 deficient ( lpr ) and nondeficient mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Meanwhile , glutamine down regulated CD 95 and CD95L expression , but up regulated CD45RO and Bcl 2 expression in activated T cells . ^^^ Studying normal peripheral lymphoproliferation , we also found that the presence of glutamine increased lymphoproliferation as well as Bcl 2 and CD 95 expression ; but decreased CD95L and activation induced T cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Hyperosmolarity triggers CD 95 membrane trafficking and sensitizes rat hepatocytes toward CD95L induced apoptosis . ^^^ The effect of hyperosmolarity on CD 95 membrane targeting and CD 95 ligand ( CD95L ) induced apoptosis was studied in rat hepatocytes . ^^^ This sensitization was abolished when hyperosmotic CD 95 membrane trafficking was prevented by cyclic adenosine monophosphate , PKC , or JNK inhibition , whereas these effectors had no effect on CD95L induced apoptosis in normoosmotically exposed hepatocytes . ^^^ CD95L addition under normoosmotic conditions caused CD 95 membrane trafficking , which was sensitive to JNK inhibition , but not to cyclic adenosine monophosphate or inhibition of PKC , Erks , and p 38 ( MAPK ) . ^^^ Hyperosmotic hepatocyte shrinkage induces CD 95 trafficking to the plasma membrane , which involves JNK , PKA , and PKC dependent mechanisms and sensitizes hepatocytes toward CD95L mediated apoptosis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of the CD 95 ( APO 1 / Fas ) ligand ( CD95L ) is critically involved in activation induced cell death ( AICD ) of activated T cells . ^^^ Administration of vitamin E suppresses CD95L mRNA expression and protects T cells of HIV 1 infected individuals from CD 95 mediated apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND / AIMS : The effect of CD 95 ligand ( CD95L ) and cycloheximide ( CHX ) on CD 95 membrane targeting and apoptosis was studied in activated , cultured rat hepatic stellate cells ( HSC ) . ^^^ RESULTS : Neither CD95L nor CHX alone induced CD 95 membrane trafficking and HSC apoptosis . ^^^ Inhibition of JNK abolished the CD 95 membrane targeting in response to CD95L / CHX , however had little effect on the apoptotic response . ^^^ Likewise , 8 CPT cAMP inhibited CD 95 membrane targeting , but did not prevent apoptosis induction by CD95L / CHX . ^^^ CONCLUSION : Sensitization of HSC towards CD95L induced apoptosis by cycloheximide is accompanied by a JNK dependent CD 95 membrane targeting , which , however , has little impact for the apoptotic response . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Treatment of CD95L transduced cells with IFN gamma causes apoptosis within 24 to 36 hours that can be blocked by antagonistic anti CD 95 antibody or by the caspase inhibitory peptide zVAD FMK . ^^^ Untransduced HUVEC treated with IFN gamma also undergo CD 95 initiated apoptosis when mixed with CD95L transduced HUVEC or when incubated with pharmacologically activated cytolytic T lymphocytes . ^^^ Overexpression of CD 95 in HUVEC confers sensitivity to CD95L in the absence of IFN gamma treatment . ^^^ We conclude that IFN gamma induces sensitivity of endothelium to CD95L mediated apoptosis , and that this response may result from increased expression of CD 95 and / or pro caspase 8 . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Transient overexpression of caspase 9S protects LN 229 astrocytoma cells from CD 95 ligand ( CD95L ) mediated apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The death receptor CD 95 ( APO 1 / Fas ) and its ligand ( L ) CD95L are critically involved in activation induced cell death ( AICD ) of activated T cells . ^^^ Here we show that the anti inflammatory sesquiterpene lactone parthenolide derived from the European traditional herb medicine feverfew and many Mexican India medicinal plants suppresses expression of the CD95L and CD 95 at the mRNA levels , thus , preventing T cells from AICD . ^^^ Aberrant expression of CD 95 and , particularly CD95L is dangerous and may lead to severe diseases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We investigated the mRNA expression of the apoptosis mediators cellular FLICE inhibitory protein ( cFLIP ) , caspase 8 , CD 95 and CD95L in peripheral blood mononuclear cells ( PB MNCs ) from MS patients using real time PCR . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Hyperosmolarity and CD95L trigger CD95 / EGF receptor association and tyrosine phosphorylation of CD 95 as prerequisites for CD 95 membrane trafficking and DISC formation . ^^^ The mechanisms underlying CD 95 ligand ( CD95L ) and hyperosmolarity induced activation of the CD 95 system [ Reinehr , R . , Graf , D . , Fischer , R . , Schliess , F . , and Haussinger , D . ( 2002 ) Hepatology 36 , 602 614 ] as initial steps of apoptosis were studied . ^^^ Addition of CD95L also induced EGFR and JNK activation , EGFR / CD95 association , CD 95 tyrosine phosphorylation , DISC formation , and CD 95 membrane targeting with an inhibitor sensitivity profile similar to that of hyperosmotic CD 95 activation , except that inhibition of PKC was ineffective . ^^^ The data suggest that moderate hyperosmolarity or CD95L trigger oxidative stress and EGFR activation followed by a JNK dependent EGFR / CD95association and CD 95 tyrosine phosphorylation , probably through EGFR tyrosine kinase activity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The effect of IFN a is not accompanied by a modulation of CD 95 , CD95L , p 53 , p 21 ( WAF 1 ) , p 27 , bcl 2 , bcl xL , bax , NFkappaB , or IkappaB gene expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The CD 95 ( APO 1 / Fas ) ligand ( CD95L ) is induced in response to a variety of signals including TCR / CD3 stimulation or application of chemotherapeutic drugs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 ( Fas / APO 1 ) / CD95L in the gastrointestinal tract : fictions and facts . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression and signaling by Fas and its ligand ( FasL , CD95L ) is a tightly regulated process essential for key physiological functions in a variety of organs , including the maintenance of immune homeostasis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activation induced cell death ( AICD ) , a process mediated by CD 95 and CD 95 ligand ( CD95L ) , plays a critical role in regulating homeostasis of the immune system . ^^^ Myriocin did not modulate the expression of CD 95 or CD95L , instead , it interfered with the early steps of CD 95 mediated caspase activation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
During the apoptotic process , we showed that expressions of CD 95 , CD95L and Nur 77 were enhanced in stimulated TJK cells but not in control cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 ligand ( CD95L , Fas , Apo 1 ) is a death ligand that triggers apoptosis in susceptible target cells . ^^^ CD 95 ligand ( CD95L , Fas , Apo 1 ) is a death ligand that triggers apoptosis in susceptible target cells . ^^^ Cell death after CD95L or CD 95 agonistic antibody treatment was assessed by crystal violet assay and DNA fragmentation was measured by comet assay . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Moreover , IL 4 and CD 28 costimulation restores the susceptibility of NOD CD8+ T cells to AICD , and this is associated with increased expression of CD 25 , CD 95 , CD95L , and TNFR 2 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In murine models of autoimmune lupus , for example , mutations in the death receptor Fas ( CD 95 ) or in its ligand , FasL ( CD95L ) , have been identified and shown to render lymphoid cells resistant to apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , CD95L blocking had no effect on cisplatin induced apoptosis in Tera CP or Scha , an intrinsic resistant TGCT cell line , nor did anti CD 95 antibody induce additional apoptosis in cisplatin treated Tera CP or Scha cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
PURPOSE : To characterize daunorubicin induced cell death in cultured human retinal pigment epithelial ( RPE ) cells and its modulation by CD 95 ligand ( CD95L ) . ^^^ CD 95 and CD95L expression were examined by immunohistochemistry , flow cytometry , immunoblot , and RT PCR . ^^^ RESULTS : RPE cells expressed both CD 95 and CD95L , but only CD 95 was expressed at the cell surface . ^^^ Daunorubicin induced RPE cell apoptosis was associated with enhanced CD 95 and CD95L expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tumour necrosis factor related apoptosis inducing ligand ( TRAIL ) and CD 95 ligand ( CD95L ) are potent inducers of apoptosis in various tumour cell types . ^^^ The study aim was to investigate whether anticancer agents can modulate similarly TRAIL receptor and CD 95 membrane expression and TRAIL and CD95L sensitivity . ^^^ Sensitivity to TRAIL or CD95L agonistic anti CD 95 antibody was determined with cytotoxicity and apoptosis assays . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Freshly isolated B cells express low levels of CD 95 and CD 95 ligand ( CD95L ) ( 19 and 21 % , respectively ) . ^^^ Expression is up regulated on culture in the presence of a combination of IL 2 , IL 4 , and eotaxin / CCL11 ( 88 % CD 95 and 84 % CD95L ) . ^^^ We therefore propose that ligation of such newly induced CCR 3 on peripheral and germinal B cells by eotaxin / CCL11 leads to the enhanced levels of CD 95 and CD95L expression . ^^^ Ligation of CD 95 by its CD95L expressed on neigboring B cells triggers relevant death signaling pathways , which include an increase in levels of Bcl 2 expression , its functional activity , and the release of cytochrome c from the mitochondria into the cytosol . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Death receptor mediated apoptosis of human malignant glioma cells triggered by CD 95 ligand ( CD95L ) or Apo 2 ligand / tumor necrosis factor related apoptosis inducing ligand ( Apo2L / TRAIL ) share several features , including processing of multiple caspases and mitochondrial cytochrome c release . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It is well established that gliomas suppress immune reactivity via a number of mechanisms , including expression CD 95 ligand ( CD95L ) , which induces apoptosis of immune effector cells , and secretion of immunosuppressive factors such as transforming growth factor beta ( TGFbeta ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The results showed that CD 22 , CD 20 , CD62L , CD 40 , CD 24 , CD79b , CD79a , and FMC 7 were almost positive in the circulating B cell population , whereas CD11a , CD 80 , CD 103 , CD 10 , CD40L , CD 54 , CD95L , CD 86 , and CD 95 were almost negative in the peripheral blood B lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Overexpression of c myc in fibroblasts causes apoptosis under low serum conditions in a process that requires the interaction of CD 95 and CD95L on the surface . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In HL 60 and RL , cell cycle analysis showed , at a distinct SubG 1 region , that CD 95 and CD 95 ligand ( CD95L ) expression was upregulated , caspase 8 and caspase 3 were activated , and Bcl 2 protein expression was downregulated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 and CD 95 ligand ( CD95L ) are critical molecules of the immune system . ^^^ In this study , we formally demonstrate that the reduced activity of soluble CD95L is due to its inability to oligomerize the CD 95 receptor , an event that is critical for initiating death signaling from the receptor . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The spontaneous death of CD4+ and CD8+ T cells was not prevented by a decoy CD 95 receptor or by a broad spectrum caspase inhibitor ( zVAD fmk ) , suggesting that this form of cell death is independent of CD95 / CD95L interaction and caspase activation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here , we demonstrate expression of CD 95 in 15 / 17 human melanoma cell lines analysed , but complete lack of CD 95 ligand ( CD95L ) . ^^^ Activation of caspase 8 , Bid cleavage , cytochrome c release and caspase 3 activation followed after CD95L induction indicating a functional CD 95 signaling cascade . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Both CD95L and anti CD 95 antibodies triggered caspase activation followed by apoptotic death in fully pro inflammatory astrocytes , whereas resting cells were totally resistant . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The effect of peroxynitrite ( ONOO ( ) ) on modulation of the hyperosmotic and CD 95 ligand ( CD95L ) induced CD 95 activation process was studied . ^^^ Pretreatment of hepatocytes with ONOO ( ) inhibited CD95L and hyperosmolarity induced CD 95 membrane trafficking and formation of the death inducing signaling complex , but not epidermal growth factor receptor activation and its association with CD 95 . ^^^ When ONOO ( ) was added after induction of CD 95 tyrosine phosphorylation by CD95L or hyperosmolarity , tyrosine nitration of CD 95 was largely prevented and death inducing signaling complex formation occurred . ^^^ CD 95 tyrosine nitration abolished the hyperosmotic sensitization of hepatocytes toward CD95L induced apoptosis . ^^^ Additionally , in CD 95 yellow fluorescent protein transfected Huh 7 hepatoma cells , ONOO ( ) induced CD 95 Tyr nitration and prevented CD95L induced Tyr phosphorylation and apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A population based study of CD 95 and CD95L in MS . ^^^ We studied the association of CD 95 and CD95L polymorphisms with MS in 221 unique patients representing 79 % ascertainment in Olmsted County , MN , and 442 gender , age and ethnicity matched controls . ^^^ We did not find an association between CD95L and susceptibility to MS nor CD 95 or CD95L and age of onset , disease course and disease severity . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We investigated the role of CD 95 and CD95L in As2O3 mediated apoptosis in various lympho haematopoietic cell lines . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The immunoprofile of the cells was concordant with that of MM cells : positive for CD 10 , CD 28 , CD 38 , CD 138 , CD 56 , CD49d , CD 44 , CD 54 and CD 58 , negative for CD 19 , CD 40 , CD 95 , CD95L , CD 34 , CD 2 and CD 5 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , CD 95 induction did not make cells from normal donors or aplastic anemia patients susceptible to induction of apoptosis by agonistic anti CD 95 antibodies , soluble CD 95 ligand , or membrane bound CD95L . ^^^ In vivo CD95L is required for CD 95 induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : After L OHP treatment of the HCT 15 human colon cancer cell line , apoptosis was evaluated by DNA laddering detection and by flow cytometry ; the effect on specific caspase 3 , 8 and 9 inhibitors , mitochondrial membrane permeability transition , cytochrome C release and expression of CD 95 and CD95L were also assessed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To determine the involvement of these ligands in SCI induced damage , we neutralized the activity of CD 95 ligand ( CD95L ) and / or TNF in spinal cord injured mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Triggering of the CD 95 pathway in HRS cells is indicated by the presence of CD95L in cells surrounding them as well as confocal microscopy showing c FLIP predominantly localized at the cell membrane . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We studied the expression of CD 95 and CD95L in CD34+ cells of patients with newly diagnosed MDS by flow cytometry , and examined the relation between this expression and FAB and WHO types , total number of CD34+ bone marrow ( BM ) cells and the degree of peripheral cytopenias . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Supernatants from dying control cells contained CD 95 ligand ( CD95L ) , and antibody mediated neutralization of CD95L prevented these supernatants from complementing HIV 1 in inducing CD4+ T cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
PURPOSE : To determine the extent to which CD 95 ligand ( CD95L ) expressed on corneal epithelium and endothelium influences survival of cornea grafts placed orthotopically and heterotopically in the anterior chamber ( AC ) , an immune privileged site . ^^^ METHODS : Corneas from eyes of C57BL / 6 ( B 6 ) and B6 . gld ( CD95L deficient ) mice were ( 1 ) rendered into small full thickness fragments , with or without an epithelial layer , and placed behind recipient corneas in the ACs of BALB / c eyes , while BALB / c corneas were similarly implanted in eyes of B 6 and B6 . lpr ( CD 95 deficient ) mice ; or ( 2 ) corneas were grafted orthotopically in BALB / c eyes as intact corneas or as composite corneas in which epithelium from one donor source was layered in vitro onto epithelium deprived stroma+endothelium from another donor source before grafting . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 expression was assessed by FACS analysis and CD95L mRNA was measured by reverse transcription polymerase chain reaction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Decreased lymphoproliferation and increased frequencies of Annexin positive cells and of T cells bearing CD 95 , CD95L or CTLA 4 were observed in the spleen from immunized / infected mice , as well as lower IL 2 and increased TGF beta production in comparison with only immunized mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
There is a well described upregulation of the apoptosis inducing CD95 / L system within the CNS after trauma , yet a comparison of caspase 3 staining patterns between CD 95 ( Ipr ) and CD95L ( gld ) deficient with non deficient mice ( C57 / bl6 ) provided no evidence for CD95L mediated neuronal cell death in this setting . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
After 48 h of EEPP treatment , the apoptosis of Hep G 2 cells was found to associate with an elevated p 53 , and CD 95 and CD95L proteins expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
PGE 2 up regulated CD 95 and CD95L expression in developing eosinophils . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , Type 1 cancer cells are resistant to induction of apoptosis by soluble CD 95 ligand ( CD95L ) , which does not induce efficient formation of the death inducing signaling complex ( DISC ) . ^^^ Here , we report that tumor cells expressing a CD 95 allele that lacks a functional DD , splenocytes from heterozygous lpr ( cg ) mice , which express one mutated CD 95 allele , and Type 1 tumor cells stimulated with soluble CD95L can all die through CD 95 when protein synthesis or nuclear factor kappa B is inhibited . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Functionally , CD 40 stimulated B CLL cells became resistant to drug induced apoptosis and , despite upregulation of CD 95 and Bid , were not sensitive to CD95L . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( CD 95 ) , FasL ( CD95L ) , and TRAIL ( TNF related apoptosis inducing ligand ) with its receptors DR 4 ( Death Receptor 4 ) , and DR 5 ( Death Receptor 5 ) . ^^^ Fas ( CD 95 ) , FasL ( CD95L ) , and TRAIL ( TNF related apoptosis inducing ligand ) with its receptors DR 4 ( Death Receptor 4 ) , and DR 5 ( Death Receptor 5 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
No effect of the two cytokines on major members of apoptosis regulating systems ( CD 95 , CD95L , bcl 2 , bax , bcl xL , p 53 , p21WAF1 , p 27 , NFkappaB ) could be observed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The anti apoptotic activity of alpha MSH is not mediated by filtering or by induction of melanin synthesis in melanocytes . alpha MSH neither leads to changes in the cell cycle distribution nor induces alterations in the expression of the apoptosis related proteins Bcl ( 2 ) , Bcl ( 10 ) , Bax , p 53 , CD 95 ( Fas / APO 1 ) , and CD95L ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Indeed , we found that treatment of Jurkat cells with 3 , 4 , 5 THS , unlike treatment with resveratrol , induced activation of caspase 8 and apoptosis by a Fas associated death domain ( FADD ) protein dependent mechanism without involving the known death ligands CD 95 ligand ( CD95L ) , tumor necrosis factor alpha ( TNFalpha ) and TNF related apoptosis inducing ligand ( TRAIL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Induction of apoptosis has been demonstrated previously by overexpression of CD 95 ligand ( CD95L ) in cultured human melanoma cells . ^^^ By applying a tyrosinase promoter CD95L construct , apoptosis was selectively induced in SK Mel 19 , SK Mel 13 , MeWo as well as in A 375 , which was characterized by high CD 95 surface expression and high sensitivity to agonistic CD 95 activation . ^^^ Also , resistance to agonistic CD 95 activation seen in MeWo characterized by weak CD 95 surface expression was overcome by overexpression of CD95L . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Death ligands such as CD 95 ligand ( CD95L ) have limited activity against glioma cells under normoxic conditions . ^^^ We investigated the effect of co exposure to acute hypoxia and CD 95 ligand in three human malignant glioma cell lines with different susceptibility to CD95L under normoxic conditions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This went along with an increase of CD 95 and CD95L surface expression , shedding of CD95L into the supernatant , cleavage of caspase 3 and caspase 8 , and elevated JNK 2 , c Jun , and CD95L mRNA expression . ^^^ However , after 48 h , the CD95 / CD95L expression pattern switched back to CD 95 / CD95L+ and the specific death rate decreased . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
As an attempt to experimentally induce antigen ( Ag ) specific immunosuppression , we have previously created CD 95 ligand ( CD95L ) transduced dendritic cells ( DC ) , which delivered apoptotic , but not activation , signals to CD4+ T cells in vitro in an Ag dependent manner . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In vivo upregulation of CD 95 and CD95L causes synergistic inhibition of angiogenesis by TSP 1 peptide and metronomic doxorubicin treatment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Impaired CD 95 expression predisposes for recurrence in curatively resected colon carcinoma : clinical evidence for immunoselection and CD95L mediated control of minimal residual disease . ^^^ PATIENTS AND METHODS : CD 95 and CD95L expression was examined by immunohistochemistry in 128 R 0 resected UICC ( International Union against Cancer ) stage II / III colon carcinomas and correlated with disease free survival . ^^^ The CD95L counterattack is not a relevant feature in colon carcinoma but CD95L+TIL may contribute to tumour control in the early stages of the disease , exerting a concurrent selection pressure in the direction of CD 95 abrogation / resistance . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We and others have previously shown that HIV 1 trans activator of transcription ( HIV 1 Tat ) sensitizes T cells toward CD 95 mediated apoptosis and up regulates CD95L expression by affecting the cellular redox balance . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increases in co stimulatory ligands CD 40 and CD 80 , plus increased leukocyte apoptosis resistance with reduced CD 95 , CD95L , and CD120b expression , were associated with successful alopecia induction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The intravitreal application of daunorubicin combined with CD 95 ligand ( CD95L ) could provide a new therapeutic strategy . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Autoimmune lymphoproliferative syndrome type Ia ( ALPS Ia ) is caused by mutations in the CD95 / APO1 / FAS ( TN FRSF 6 ) gene , which lead to a defective CD 95 ligand ( CD95L ) induced apoptosis . ^^^ Soluble CD 95 ( sCD 95 ) has been suggested to play an important role in the pathogenesis of diverse autoimmune and malignant diseases by antagonizing CD95L . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Changes in the expression of CD 95 and / or its ligand CD95L are frequently found in human cancer . ^^^ Recent data have illuminated unknown activities of CD 95 in tumor cells with downregulated or mutated CD 95 in the presence of increased CD95L . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 ligand ( CD95L ) triggers a rapid formation of reactive oxygen species ( ROS ) as an upstream event of CD 95 activation and apoptosis induction in rat hepatocytes . ^^^ The data suggest that CD95L induced apoptosis involves a sphingomyelinase and PKCzeta dependent activation of NADPH oxidase isoforms , which is required for Yes / EGFR / CD95 interactions as upstream events of CD 95 activation . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This activation appears to occur downstream of VEGF ( vascular endothelial growth factor ) , a well known proangiogenic factor , and is related to repression of proapoptotic FAS ( CD 95 ) / FASL ( CD95L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The CD 95 ( Apo 1 / Fas ) / CD95 ligand ( CD95L ) system is best characterized as a trigger of apoptosis . ^^^ Nevertheless , despite broad expression of CD95L and CD 95 in the developing brain , absence of functional CD 95 ( lpr mice ) or CD95L ( gld mice ) does not alter neuronal numbers . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increased peripheral blood number of lymphocytes expressing induction of apoptosis CD 95 receptors and ligand for this receptor CD95L ( Fas L ) can lead to intensification of lymphocyte apoptosis and may be the reason for T cell deficit development . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Because other members of the TNF family such as TRAIL and CD 95 ligand ( CD95L ) are known to interfere with erythroblast growth and differentiation , we investigated the role of different TNF / TNFR family proteins as potential effectors of IFN gamma in the immature hemopoietic compartment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
ABT 510 , a peptide derivative of thrombospondin , kills endothelial cell by increasing CD95L , a ligand for the CD 95 death receptor . ^^^ These antitumor effects were accompanied by major decreases in microvascular density and concomitant increases of the vascular CD 95 , CD95L , and apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 or the Fas / Apo 1 and its ligand CD95L participate in regulating lymphocyte populations and therefore influence various aspects of immune responses . ^^^ Mutational abnormalities resulting from synthesis of proteins by the CD 95 and / or its ligand CD95L may result in alterations in the apoptotic pathways . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This in vitro study examined whether hepatocytes can eliminate other cells via a CD 95 ligand ( CD95L or FasL ) / CD95 ( Fas ) mediated mechanism and whether this cytotoxic activity can be modulated by cytokines such as interferon gamma ( IFN gamma ) or tumor necrosis factor alpha ( TNF alpha ) . ^^^ We have found that normal woodchuck and human hepatocytes , both cultured and primary freshly isolated , as well as human HepG 2 cells , intrinsically transcribe not only CD 95 but also CD95L when examined by reverse transcription polymerase chain reaction ( RT PCR ) assays . ^^^ The functional competence of CD95L , which was detectable in hepatocytes and HepG 2 cells by Western blotting , was confirmed in bioassays by induction of apoptosis of CD 95 bearing P 815 and LS102 . 9 cell targets and validated by inhibition of the cell killing with CD 95 antagonistic antibody or with a general caspase inhibitor . ^^^ In conclusion , hepatocytes express both CD95L and CD 95 and they can induce death of other cells by a CD95L dependent mechanism . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The aim of this study was to estimate the expression of chosen apoptotic molecules CD 95 ( Fas ) and CD95L ( FasL ) on the surface of thyroid follicular cells in application of mouse monoclonal antibodies # 64 which recognized B antigen regions of thyroid peroxidase ( TPO ) and infiltrating inflammatory cells . ^^^ In addition , on the surface of thyroid follicular cells in patients with GD ( p < 0 . 01 , p < 0 . 01 ) and NTMG ( p < 0 . 001 , p < 0 . 004 ) we observed a lower percentage of thyrocytes with CD 95 and CD95L molecules than in cases with HT . ^^^ Cytofluorometric analysis of chosen markers of apoptosis CD95 / CD95L ( Fas / FasL ) in thyroid tissues from young patients with Graves ' disease and Hashimoto ' s thyroiditis ] . ^^^ The analysis of Fas and FasL expression in thyroid tissues revealed significantly increased percentage of intrathyroidal T cells with CD95+ ( p < 0 . 005 , p < 0 . 001 ) , CD95L+ ( p < 0 . 02 , p < 0 . 01 ) and both CD95 / CD95L ( ns , p < 0 . 05 ) expression in comparison to percentages of T cells in patients with HT and NTMG . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Therefore , we examined the development of pneumonitis in CD 95 and CD95L deficient and wild type mice after single irradiation with 0 or 12 . 5 Gy by measuring breathing frequency , pulmonary resistance , and histopathologic changes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the Fas mediated pathway , engagement of a CTL membrane ligand with an apoptosis inducing target cell surface receptor , such as the FasL with Fas , triggers programmed disintegration of the CTL bound target ; secretion of granzymes and pore formation by perforin are not involved in this receptor mediated mechanism . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Instead , these autoimmune T cells mount a vigorous proliferative response , suggesting a critical role for Fas / FasL interactions in this form of autoapoptosis . ^^^ In the current study , we found that SEB induced AICD was tied to the rapid induction of FasL expression in cells constitutively expressing high levels of Fas . ^^^ The rapid onset of apoptosis in normal T cells subsequent to restimulation with SEB was in direct contrast to the proliferative response of the initial cultures , even though comparable levels of Fas and FasL RNA were found in T cells after 1 degree and 2 degrees challenge . ^^^ Together , these data demonstrate first , that Fas / FasL interactions are intimately tied to superantigen induced AICD , a form of autocrine cell death , and second , that FasL mediated cytotoxicity is responsible for the disappearance of normal CD4+ T cells in lpr cocultures . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / APO 1 ( CD 95 ) is a cell surface receptor which mediates apoptosis when ligated by specific antibodies or by its recently cloned natural ligand , FasL . ^^^ Fas / APO 1 ( CD 95 ) is a cell surface receptor which mediates apoptosis when ligated by specific antibodies or by its recently cloned natural ligand , FasL . ^^^ We have studied the cytotoxic potential of FasL in vivo using Fas / APO 1 expressing Yac 1 cells as targets . ^^^ Specificity of FasL mediated cytotoxicity was confirmed by competition assays using soluble Fas or anti Fas / APO 1 F ( ab ' ) 2 fragments which specifically interfere with FasL Fas / APO 1 interactions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Regulation of T cell death genes : selective inhibition of FasL but not Fas mediated function . ^^^ Activation induced cell death ( AICD ) requires coexpression of Fas and FasL . ^^^ Dexamethasone ( Dex ) inhibited FasL induction and Fas up regulation , but not basal Fas expression of hybridoma T cells . ^^^ All trans retinoic acid ( RA ) inhibited FasL induction , but had little effect on Fas up regulation . ^^^ The Fas mediated death pathway distal to Fas / FasL interactions remained intact in the protected hybridoma T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The deathless hybridomas were activated to produce FasL and IL 2 , indicating that the intrinsic defect in Fas expression or up regulation resulted in AICD blockade . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
No changes were seen in the expression of tumor necrosis factors , their receptors , Fas , FasL , p 53 , or c myc , molecules which have been suggested to participate in the apoptotic process . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas L transfected Raji cells also killed LAK cells , but only if Fas L expression was amplified . ^^^ In conclusion , ( 1 ) K 562 induced death of LAK cells involves primarily CD 18 , although other molecules , such as Fas , may also be involved ; ( 2 ) K 562 mediated apoptosis of LAK cells requires tyrosine phosphorylation and protease activity ; ( 3 ) engagement of Fas by immobilized MoAb or Fas L on target cells can also kill LAK cells ; and ( 4 ) Fas immobilized MoAb synergizes with coimmobilized MoAb to CD11a , CD11b , or CD 18 for LAK cell killing . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Anti TCR induced apoptosis of T cell hybridomas requires de novo macromolecular synthesis , including up regulation of Fas and FasL . ^^^ The Fas FasL interaction then activates the apoptosis program . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , when cell death was absent due to defects in Fas or FasL , immune tolerance was not observed . ^^^ Additionally , we show that while Fas / FasL mediated apoptosis occurred in the eye , it was apoptotic cell death that was critical for tolerance induction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : Genetic abnormalities in the Fas receptor or its trimeric ligand , FasL , result in massive T cell proliferation and a lupus like autoimmune syndrome , which was initially attributed to excessive lymphoproliferation but is now ascribed to the absence of Fas mediated cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This B cell fate decision is determined by the concerted action of two surface proteins on activated T cells , CD 40 and Fas ligands ( CD40L and FasL ) , whose effects are switched by signals from the B cell antigen receptor ( BCR ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These findings suggest that , in RCC , apoptosis is induced by lymphocytes bearing Fas L , and that it is achieved through the proteolytic action of CPP32 / YAMA and / or ICE , or another member of the ICE / ced 3 protease family . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The cell killing effects of the cytokines TNF alpha and FasL are mediated by the distinct cell surface receptors TNFR 1 , TNFR 2 and Fas ( also known as CD95 / APO 1 ) , which are all members of a receptor superfamily that is important for regulating cell survival . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The renal cell carcinoma lysis by a specific cytotoxic T cell clone is independent of the Fas / Fas L cytotoxic pathway . ^^^ To investigate the role of the Fas / FasL pathway in the cytotoxic response against RCC cells , we analyzed the induction of Fas L on a tumor specific T cell clone ( CTL8C2 ) , previously generated against one RCC cell line . ^^^ Fas L expression on CTL8C2 was detected by RT PCR after stimulation with autologous tumor cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Melanoma cells were found to express Fas ( also called Apo 1 or CD 95 ) ligand ( FasL ) . ^^^ In contrast , tumorigenesis was delayed in Fas deficient lpr mutant mice in which immune effector cells can not be killed by FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Different levels of Fas , Fas L , and Bcl 2 gene products were not detected between SLE sera treated cells and the controls . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The data show that CD8+ T cells were lysed by activated CD4+ helper T cells by a Fas / FasL mediated mechanism . ^^^ CD4+ T cells were not lysed by activated CD8+ T cells , although Fas and FasL were equally expressed and anti Fas Abs induced apoptosis in both CD4+ and CD8+ T cell populations . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The ligand for Fas ( FasL ) was shown to be constitutively expressed both in normal and HT thyrocytes and was able to kill Fas sensitive targets . ^^^ Thus , Fas FasL interactions among HT thyrocytes may contribute to clinical hypothyroidism . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The present study examined the mechanism of HLA class 2 mediated apoptosis and describes the essential role of the molecule Fas and its ligand ( FasL ) . ^^^ The crucial role of Fas / FasL interactions was confirmed by the absence of cell death via HLA class 2 in B cells lacking Fas expression , and by the significant inhibition of HLA class 2 mediated apoptosis in the presence of either an antagonistic anti Fas or anti FasL antibody . ^^^ These data demonstrate FasL expression on activated human B lymphocytes and support the idea that antigen presentation could contribute to the regulation of lymphocyte populations via Fas and FasL interactions . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Experiments using mice homozygous for the lpr or gld mutations showed that pulmonary lymphocyte apoptosis depended on expression of Fas ( CD 95 ) and its ligand ( Fas L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The interaction of Fas ( CD 95 ) , a member of the tumor necrosis factor receptor ( TNFR ) family , and its ligand ( FasL ) triggers programmed cell death ( apoptosis ) and is involved in the regulation of immune responses . ^^^ Although the Fas FasL interaction is conserved across species barriers , little is currently known about the molecular details of this interaction . ^^^ Therefore , the binding of FasL involves residues in two domains that correspond to positions critical for ligand binding in other family members ( TNFR and CD 40 ) but are conserved between murine and human Fas . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We have evaluated the role of the endogenous Fas Fas ligand ( FasL ) interaction in the induction of this spontaneous apoptosis and found that a Fas immunoglobulin ( Ig ) fusion protein , an antagonistic anti Fas monoclonal antibody and a rabbit anti FasL antibody all greatly reduced the onset of apoptosis . ^^^ Treatment of the cells with growth factors or cytokines that prevented spontaneous apoptosis had no major effects on the expression of Fas or FasL . ^^^ Additionally , monocyte derived macrophages were found to express both Fas and FasL but did not undergo spontaneous apoptosis and were not sensitive to stimulation by an agonistic anti Fas IgM . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , the contribution of the Fas / Fas ligand ( Fas L ) system to the pathogenesis of MAIDS remained unknown . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Unequal death in T helper cell ( Th ) 1 and Th 2 effectors : Th 1 , but not Th 2 , effectors undergo rapid Fas / FasL mediated apoptosis . ^^^ T helper cell ( Th ) 1 , but not Th 2 , effectors undergo rapid Fas / Fas ligand ( FasL ) mediated , activation induced cell death upon restimulation with antigen . ^^^ Both Th 1 and Th 2 effectors express Fas and FasL , but only Th 2 effectors express high levels of FAP 1 , a Fas associated phosphatase that may act to inhibit Fas signaling . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To assess whether some of the apoptosis known to occur after ionizing radiation might be mediated by Fas / Fas ligand ( FasL ) interactions , we quantitated in vitro apoptosis by flow cytometry measurement of DNA content in splenic T and B cells from irradiated 5 to 8 month old B6 / lpr mice . ^^^ Fas / FasL interactions may thus play an important role in identifying and eliminating damaged cells after gamma irradiation and other forms of injury . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To better understand exactly how Fas / FasL interactions control autoantibody production , studies were undertaken to determine ( 1 ) what kind ( s ) of B cells are sensitive to Fas mediated apoptosis and ( 2 ) where the autoantibody producing cells in lpr mice are located . ^^^ These data are consistent with the premise that the inner PALS , and not the germinal center , is the major site of FasL regulation of B cell activity and that , as a result of genetic or inducible loss of sensitivity to Fas mediated apoptosis , autoreactive B cells may survive and differentiate in this location to cause serological autoimmunity . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas or FasL mutant and CTLA 4 knock out mice have successfully unraveled the molecular mechanisms for breakdown and maintenance of some T cell tolerance . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The activation induced expression of the immediate early gene , Nur 77 , and the T cell death genes , CD 95 ( Fas ) and CD 95 ligand ( FasL ) , were inhibited . ^^^ Functional expression of FasL cytotoxicity and the increase of cell surface Fas were also inhibited . ^^^ These observations strongly suggest a direct link between the proteasome dependent degradation of IkappaBbeta and the AICD that occurs through activation of the FasL gene and up regulation of the Fas gene . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas ( Apo 1 / CD95 ) ligand ( FasL ) plays a central role in the elimination of target cells by effector T lymphocytes and in the suppression of cellular immune responses against nonmalignant and malignant cells . ^^^ The effect was mediated via the Fas ( Apo 1 / CD95 ) receptor molecule because blocking of Fas on the target cells or the FasL on the tumor cells by receptor and ligand specific monoclonal antibodies ( MoAbs ) , respectively , protected T cells from being killed by myeloma cells . ^^^ The potential of the malignant plasma cells to extinguish target T cells was independent of their own sensitivity to the agonistic anti Fas MoAb , and FasL positive ( FasL+ ) CEM C7H2 T cells were incapable of killing myeloma cells . ^^^ Furthermore , loss of Fas expression or insensitivity to the agonistic anti Fas MoAb do not seem to be prerequisites for myeloma cells to defeat T cells via Fas / FasL interaction . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These results suggest that up regulation of the genes associated with the cell cycle and / or DNA replication , such as p 21 , cyclinG and gadd 45 rather than bax , fas , fasl and bcl 2 may be important for induction of apoptosis of this erythroleukemic cell line by p53 . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These results suggested that apoptosis induced by thymineless stress was regulated by autocrine signaling via Fas FasL interactions . ^^^ Taken together , these data demonstrate a functional Fas system in these cultured colon carcinoma cell models , and they demonstrate that Fas FasL interactions can link DNA damage induced by thymineless stress to the apoptotic machinery of colon carcinoma cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas / Fas ligand ( FasL ) pathway is widely involved in apoptotic cell death in lymphoid and nonlymphoid cells . ^^^ It has recently been postulated that many chemotherapeutic agents also induce cell death by activating the Fas / FasL pathway . ^^^ Treatment with ZB 4 , an antibody that inhibits Fas mediated cell death , failed to block etoposide induced apoptosis , raising the possibility that etoposide does not initiate apoptosis through Fas / FasL interactions . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas / Fas ligand ( FasL ) system participates in regulation of the immune system through the apoptotic process . ^^^ However , the extent to which abnormalities in this system are involved in the loss of self tolerance and development of autoimmune disease not associated with Fas / FasL mutations remains unknown . ^^^ The present study addresses this issue in Fas / FasL intact , systemic lupus erythematosus ( SLE ) prone ( NZB 10 NZW ) ( NZB / W ) F 1 mice . ^^^ The findings indicate that precursor B cells for autoantibody production and presumably autoantibody secreting cells in these mice are relatively resistant to Fas mediated apoptosis , a finding supporting the concept that abnormalities of Fas mediated apoptotic process are involved in the development of autoreactive B cells in Fas / FasL intact autoimmune disease . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We examined the contribution of Fas and its ligand ( FasL ) in the process of follicular atresia using murine intraovarian follicles and pregnant mare ' s serum gonadotropin ( PMSG ) hyperovulated eggs . ^^^ These findings were histologically confirmed by in situ hybridization using Fas and FasL specific probes . ^^^ These findings indicate that follicular atresia is caused by apoptosis , and the apoptosis associated with internucleosomal DNA fragmentation is directly regulated by the Fas / FasL system . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / FasL interactions have been shown to mediate AICD , even though the level of Fas expression in the 2 degrees SEB responder populations is no higher than in the 1 degrees cultures . ^^^ To determine whether the dissimilarity between the 1 degrees and 2 degrees cultures could be attributed to differences in FasL cytotoxic activity or in the sensitivity of the Fas apoptosis signaling pathway , we compared these parameters during the 1 degrees and 2 degrees responses of lpr and gld CD4+ T cells ( which do not undergo AICD due to a lack of Fas and an inactive FasL , respectively ) so that each parameter could be evaluated independently . ^^^ In addition , we found that the apparent level of FasL mediated cytotoxic activity in the 2 degrees lpr CD4+ T cell population is much higher than that of wild type cells , suggesting that deficient Fas expression leads to inordinately high levels of FasL expression or subsaturation of FasL binding sites . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
TRAIL is upregulated upon lymphocyte activation , as is the intensively studied ligand for Fas , FasL [ 4 ] . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In situ investigation of Fas / FasL expression in chronic hepatitis B infection and related liver diseases . ^^^ To evaluate Fas / FasL expression in hepatitis B virus related chronic liver disease , liver biopsies from 44 such cases were studied immunohistochemically . ^^^ FasL was detected in the infiltrating lymphocytes and both FasL and Fas were found in the hepatocytes . ^^^ The Fas and FasL positive cells were mostly found at the advancing edges of interphase hepatitis , and Fas / FasL expression was closely correlated with the inflammatory activity . ^^^ These results suggest that the factors which induce hepatocyte transformation might also trigger FasL expression and promote FasL / Fas mediated apoptosis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and FasL deficient mice are resistant to induction of autoimmune encephalomyelitis . ^^^ To determine the roles of Fas and FasL in the involvement of CNS autoimmune injury , we determined susceptibility to EAE of Fas or FasL deficient mice . ^^^ Compared with wild type mice , mice expressing lpr ( Fas ) and gld ( FasL ) mutations were relatively resistant to the development of clinical EAE , and this correlated with fewer inflammatory infiltrates and cells undergoing apoptosis in the CNS of the mutant mice . ^^^ These results suggest that the Fas / FasL pathway plays a critical role in the development of EAE probably by mediating apoptosis within the target tissue . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We then investigated the role of the Fas / Fas ligand ( FasL ) system in the CD 28 independent allogeneic hepatocyte rejection . ^^^ With the anti CD80 / 86 mAb treatment , hepatocytes from C57BL / 6 lpr / lpr ( B 6 lpr ) mice , which express little Fas antigen , could survive for 7 days after intrasplenic transplantation , and hepatocytes from C57BL / 6 ( B 6 ) mice could also survive for 7 days in the spleen of C3H / He gld / gld ( C3H gld ) mice , which express no functional FasL . ^^^ These results indicated that the Fas / FasL system plays a critical role in the CD 28 independent pathway of allogeneic hepatocyte rejection . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The interaction between the surface molecule Fas and its ligand ( FasL ) has been proposed as a primary mechanism initiating T cell apoptosis . ^^^ Defects in the Fas / FasL apoptosis pathway have been shown to result in autoimmune disease in humans and in murine models . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To evaluate the contribution of Fas / Fas ligand ( FasL ) interaction to the induction of ACAID to alloantigens , gld and lpr mutant mice were used in conjunction with normal C3H , MRL , and BALB / c mice . ^^^ These results show that interaction of the Fas and FasL is required to induce ACAID to allogeneic cells . ^^^ In the absence of Fas expression on donor splenocytes , or FasL expression by the recipient , AC inoculation primes for a DTH response rather than inducing ACAID . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas is an apoptosis signaling receptor that triggers cell death upon binding to its ligand ( FasL ) . ^^^ As a consequence of this defect , activated T cells accumulating in this strain overexpress the FasL and can therefore mediate in vitro Fas dependent cytotoxicity . ^^^ To determine whether hepatic injury could be the result of an interaction between T lymphocytes bearing FasL and Fas expressing liver cells , the livers of lethally irradiated MRL+ / + recipients reconstituted with MRL / lpr lymphoid cells were studied . ^^^ These donor derived intrahepatic lymphocytes overexpressed the FasL and exerted in vitro Fas mediated cytotoxicity against Fas+ thymocytes , which was specifically inhibited by soluble recombinant Fas in a dose dependent manner . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( CD 95 ) and its ligand ( FasL ) interaction plays a pivotal role in T cell receptor ( TCR ) mediated apoptosis . ^^^ Fas ( CD 95 ) and its ligand ( FasL ) interaction plays a pivotal role in T cell receptor ( TCR ) mediated apoptosis . ^^^ Our results therefore provide a mechanism of how Fas FasL interactions lead to T cell death in an antigen specific manner via repetitive antigen stimulation . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the role of the Fas Fas ligand ( FasL ) interaction in HIV 1 induced apoptosis of primary CD4+ T lymphocytes . ^^^ DESIGN : Activated CD4+ T lymphocytes are the main target of HIV , and T cell activation leads to the expression of Fas FasL and enhances HIV mediated apoptosis . ^^^ The modulation of Fas and FasL expression and its role in HIV induced cell death was also investigated . ^^^ Fas and FasL expression was analyzed at the RNA level by reverse transcription polymerase chain reaction and at the protein level by flow cytometry . ^^^ The contribution of Fas FasL interactions to apoptosis was examined by blocking experiments using the antagonist ZB 4 anti Fas antibody . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In Hashimoto ' s thyroiditis which is a typical organ specific autoimmune disease , Fas FasL mediated apoptosis has been demonstrated as the mechanism of follicular epithelial cell death in which Fas is expressed by IL 1 beta stimulation of FasL is constitutively expressed on follicular epithelial cells . ^^^ Immunohistochemical study on Fas and FasL expression on follicular epithelial cells of various thyroid diseases showed that Fas and FasL were strongly expressed on follicular epithelial cells in Hashimoto ' s thyroiditis and thyroid cancer . ^^^ Fas and FasL expression on follicular epithelial cells were well correlated . ^^^ Therefore , it was concluded that FasL expressed constitutively on follicular epithelial cells interacts with Fas on epithelial cells expressed by IL 1 beta stimulation to induce apoptosis of epithelial cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expansion or elimination of a B cell clone is determined through a complex interaction of the tumour necrosis factor receptor / nerve growth factor receptor family members CD 40 and Fas , which are expressed on the B cell surface , with their respective physiological ligands ( CD40L and FasL ) expressed on the surface of CD4+ T cells . ^^^ We now present evidence that Ramos BL B cells constitutively express both Fas and FasL on their surface and that expression of Fas , but not FasL , is enhanced following ligation of CD 40 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this study , we investigated both the expression of Fas / Fas ligand ( FasL ) and lymphocyte subset reconstitution in patients who underwent HLA matched related allogeneic BMT ( n = 16 ) and normal donors ( n = 10 ) , and several distinct features were observed . ^^^ Fas antigen was highly coexpressed on most of the lymphocyte subsets , especially on CD8+ cells ( P < 0 . 01 ) , and also , significantly higher coexpression of FasL on CD8+ cells was found in patients with aGVHD ( P < 0 . 01 ) . ^^^ In summary , an increase in the percentage of CD8+ cells which express Fas and its ligand in patients with aGVHD after BMT points to a possible role for the Fas / FasL pathway in the effector phase of aGVHD . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( CD 95 ) ligand ( L ) is a death factor that binds to its receptor , Fas , and induces apoptotic cell death , a crucial process in immunological tolerance . gld ( generalized lymphoproliferative disorder ) mice , which have a point mutation in the FasL gene , develop spontaneous systemic autoimmune syndromes characterized by hypergammaglobulinaemia and lymphoid hyperplasia owing to accumulation of abnormal B220+ CD3+ cells . ^^^ Fas ( CD 95 ) ligand ( L ) is a death factor that binds to its receptor , Fas , and induces apoptotic cell death , a crucial process in immunological tolerance . gld ( generalized lymphoproliferative disorder ) mice , which have a point mutation in the FasL gene , develop spontaneous systemic autoimmune syndromes characterized by hypergammaglobulinaemia and lymphoid hyperplasia owing to accumulation of abnormal B220+ CD3+ cells . ^^^ We characterized the cellular mechanisms ( functionally and histologically ) of the above phenomena in gld mice after bone marrow transplantation ( BMT ) to determine the role of apoptosis via Fas / FasL interactions in inducing and maintaining self tolerance in vivo . ^^^ Our results indicated that apoptosis via Fas / FasL interactions can directly eliminate pathogenic cells responsible for autoimmunity in the periphery and possibly in the thymus in vivo . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression and action of Fas / Fas ligand ( FasL ) in multiple sclerosis has been postulated as a major pathway leading to inflammatory demyelination . ^^^ To formally test this hypothesis , C57BL / 6 lpr and gld mice , which due to gene mutation express Fas and FasL in an inactive form , were immunized with myelin oligodendrocyte glycoprotein peptide ( 35 55 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Detection of Fas and its ligand , FasL , in mouse thymus by in situ hybridization . ^^^ Part of the apoptotic process in lymphocytes involves the Fas receptor , which can transduce a cell death signal after interaction with its ligand , FasL . ^^^ Many studies concerning expression of Fas and FasL in the thymus have been performed , but no detailed information about in situ expression patterns of mRNA inside the thymus is available . ^^^ In the present study the expression of Fas and FasL was evaluated by non radioactive in situ hybridization in the thymi of normal mice and compared with the results of lpr and gld mice , the two mouse models with mutations of Fas and FasL , respectively . ^^^ Together , these results are consistent with absence of a role for the Fas FasL interaction in thymocyte apoptosis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and its ligand ( FasL ) are members of the tumor necrosis factor receptor ( TNFR ) and tumor necrosis factor ( TNF ) superfamilies , respectively . ^^^ Fas FasL interactions trigger controlled cell death ( apoptosis ) in the immune system and thus play a key role in the regulation of immune responses . ^^^ We have now extended our mutagenesis analysis and identified additional residues which contribute to the Fas FasL interaction . ^^^ Although residues in all three extracellular domains were identified to contribute to binding , the Fas FasL interaction is centered on the second TNFR like domain . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
FasL / Fas ( CD 95 ligand / CD95 ) mediated cytolysis requires de novo protein synthesis of FasL by the CTL and the presence of the death receptor Fas on the target cell to induce apoptosis . ^^^ Using a CD 8 ( + ) CTL clone that kills via both the perforin / granule exocytosis and FasL / Fas mechanisms , and a clone that kills via the FasL / Fas mechanism only , we have examined the requirement of intra and extracellular Ca2+ in TCR triggered cytolytic effector function . ^^^ Thapsigargin , at low concentrations , induces this small but sustained increase in [ Ca2+ ] 1 and selectively induces FasL / Fas mediated cytolysis but not granule exocytosis . ^^^ These results further define the role of Ca2+ in perforin and FasL / Fas killing and demonstrate that differential Ca2+ signaling can modulate T cell effector functions . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activation of T cell hybridomas in vitro induces rapid Fas Fas ligand ( FasL ) mediated programmed cell death ( apoptosis ) . ^^^ In contrast , T cells activated by antigen or superantigen in vivo undergo a population expansion and then decline due to Fas FasL mediated activation induced apoptosis ( AIA ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas mediated apoptosis is a form of cell death that operates through a Fas Fas ligand ( FasL ) interaction . ^^^ Irradiated RAG 2 / recipients were reconstituted with bone marrow cells from B 6 and lpr mice ( Fas defective ) or from B 6 and gld mice ( FasL defective ) , and analyzed for long term development . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas and FasL apoptotic pathway was investigated by protein immunohistochemistry , flow cytometry , and reverse transcriptase PCR analysis to assess whether it is involved in the elimination of target and / or effector cells from the central nervous system ( CNS ) during adoptively transferred chronic relapsing experimental autoimmune encephalomyelitis ( EAE ) , a model for multiple sclerosis . ^^^ In addition to Fas and FasL , we studied Bax , an intracellular protein of the apoptotic cascade , the Bax antagonist and anti apoptotic molecule Bcl 2 , and DNA fragmentation , the final step in the apoptotic pathway . ^^^ Infiltrating CD4+ T cells and parenchymal microglia expressed Fas , FasL , and Bax , and about half of these cells showed DNA fragmentation , a combination indicative of ongoing apoptosis . ^^^ Using flow cytometry and reverse transcriptase PCR , a positive correlation was seen between disease activity and up regulation of the Fas system ; in fact , Fas and FasL were expressed at low levels at the onset of EAE and increased at the height of disease to involve about one third of all infiltrating lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We examine here whether the Fas receptor and its cognate ligand ( FasL ) are present on vesicles shed from high metastatic potential CX 1 cells and low metastatic potential MIP 101 cells and from HuT 78 cells , respectively . ^^^ FasL bearing vesicles induce apoptosis of Fas expressing cancer cells at the same level as observed by treatment with monoclonal anti Fas antibody . ^^^ Furthermore , Fas bearing extracellular vesicles from MIP 101 but not from CX 1 cells protect the CX 1 cell line from FasL induced and anti Fas mediated apoptosis , indicating that Fas present on shed vesicles is biologically active . ^^^ Exfoliation may provide a mechanism for long range signal directed apoptosis while maintaining Fas / FasL on a membrane surface . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cell death mediated by Fas FasL interaction between glial cells and MBP reactive T cells . ^^^ In this study we examined the expression of Fas and FasL genes both in myelin basic protein ( MBP ) reactive T cells and in glial cells and the susceptibility of these cells to death induced by Fas / FasL interaction . ^^^ Both Fas and FasL gene expression is detectable in glial cells and MBP reactive T cells . ^^^ The ability to induce death of Fas expressing cells varies greatly among different lines of MBP reactive T cells , as does resistance to death induction by cells expressing FasL . ^^^ Moreover , the ability of T cells both to deliver and to resist death signals is a function of their activation status : T cells freshly activated transmit a stronger apoptotic signal to Fas positive target cells and are also more resistant to FasL induced suicide . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Pretreatment of Fas resistant CEA positive colon carcinoma target cells with IFN gamma increased their sensitivity of MD 45 scFv subclones and FasL mediated lysis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Analysis of therapy induced changes in hepatic gene expression demonstrated increased levels of IP 10 and Mig RNAs , but no increase in iNOS , Fas , or FasL RNA levels was observed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this report we investigated the possibility that mutations at the Fas ( lpr ) and Fasl ( gld ) loci , which prevent Fas mediated apoptosis and cause an early onset benign lymphoid hyperplasia and autoimmunity , also predispose mice to malignant lymphomas later in life . ^^^ The delayed development of the gld tumors indicated that genetic defects in addition to the Fas / Fasl mutations were necessary for malignant transformation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cross linking of the Fas receptor with its own ligand ( FasL ) triggers apoptosis in various systems , whereas the Bcl 2 protooncogene inhibits apoptotic cell death . ^^^ The involvement of Fas , FasL , and Bcl 2 in the apoptotic process in HT was evaluated in 15 thyroid tissue samples from patients with HT stained for apoptosis and for Fas , FasL , and Bcl 2 protein expression . ^^^ Thyroid follicles in HT samples exhibited strong staining for Fas and FasL and a high percentage of apoptosis ( 30 . 3 + / 14 . 5 % , mean + / SD ) , in contrast to normal control follicles that exhibited moderate Fas , minimal or no FasL , and hardly any apoptosis . ^^^ We conclude that follicular cells in HT undergo apoptosis by concomitant up regulation of FasL and Fas and down regulation of Bcl 2 protein . ^^^ The lymphocytes do not seem to be directly engaged in the process with their own FasL , but they may provide the appropriate cytokine milieu that , in turn , up regulates Fas and / or FasL leading to apoptosis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Control allografts showed advanced transplant arteriosclerosis , whereas tolerance induced aortic allografts displayed reduced neointimal formation , less medial atrophy , fewer apoptotic cells , and fewer Fas and FasL expressing cells . ^^^ Fas expression was found in T cells , macrophages , vascular smooth muscle cells , and endothelial cells , whereas FasL was expressed mainly by T cells and macrophages . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptotic cell death seems to implicate the Fas / Fas ligand ( L ) pathway , as reflected by an increase of Fas / Fas L expression on neutrophils treated with EBV and an increase of soluble Fas L , which may function in an autocrine / paracrine pathway to mediate cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The purpose of this study was to determine whether apoptotic cell death is involved in rat cardiac allograft rejection through both the perforin / granzyme pathway and the Fas / Fas ligand ( Fas L ) pathway . ^^^ In addition , the expression of granzyme B , perforin , Fas , and Fas L messenger RNA were analyzed by reverse transcriptase polymerase chain reaction . ^^^ Fas gene transcripts were constitutively expressed in both syngeneic and allogeneic grafts , whereas expression of Fas L was only upregulated in allografts with ongoing rejection . ^^^ CONCLUSIONS : These results suggest that myocyte apoptosis through both the perforin granzyme pathway and the Fas Fas L pathway may be involved in cardiac allograft rejection in rats . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
There was a decline in Fas L levels 8 days after EDS administration . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( also known as CD95 / APO 1 ) is a cell surface receptor and member of the tumor necrosis factor receptor superfamily which mediates apoptosis in sensitive cells upon oligomerization by specific antibodies or by its ligand ( FasL ) . ^^^ In the present investigation , alpha Fas antibodies and FasL were tested in short term monolayer cultures or in colony forming assays established from freshly resected tumors of patients with anaplastic astrocytomas ( WHO grade 3 ) and glioblastoma multiforme ( WHO grade 4 ) . ^^^ Mean cytotoxicity of glioma cell cultures treated for 48 h with alpha Fas antibodies or FasL was 9 . 6 % and 44 . 3 % , respectively . ^^^ Irrespective of whether alpha Fas antibodies or FasL were used , pretreatment with recombinant hu ( rhu ) IFN gamma and rhuTNF alpha for 48 h did not sensitize glioma cells to Fas mediated cytotoxicity . ^^^ These results suggest that Fas targeting by FasL but not by alpha Fas antibodies may provide a promising approach for locoregional glioma treatment . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We investigated the role of apoptosis and the possible involvement of Fas / Fas ligand ( FasL ) system in apoptosis during goiter formation and involution in a rat model of goiter . ^^^ We also investigated the association between Fas and FasL expression and thyrocyte apoptosis using immunohistochemistry and Western blotting . ^^^ Our results indicate that apoptosis of thyrocytes is a main factor of cell loss during goiter formation and involution and suggest that the Fas / FasL system is involved in the induction of apoptosis of these cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 ( Fas , APO 1 ) is a cell surface receptor expressed on many cells including eosinophils which mediates apoptosis when ligated by agonistic antibodies or its natural ligand FasL . ^^^ CD 95 ( Fas , APO 1 ) is a cell surface receptor expressed on many cells including eosinophils which mediates apoptosis when ligated by agonistic antibodies or its natural ligand FasL . ^^^ Functional activity for CD 95 following incubation with IFN gamma and TNF alpha was demonstrated by increased apoptosis in response to cross linking with FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Distinct regulation of T cell death by CD 28 depending on both its aggregation and T cell receptor triggering : a role for Fas FasL . ^^^ In these cells , TCR triggering induced expression of Fas and FasL , and cell death was prevented by anti Fas blocking monoclonal antibody ( MoAb ) . ^^^ Our results identify Fas and FasL as crucial targets of CD 28 in T cell death regulation and show that within the same cell population , depending on its engagement as a single signal or as a costimulus together with the TCR , CD 28 can either induce a dose dependent death signal or protect from cell death , respectively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
T cell subsets from a patient with DiGeorge anomaly were examined for the expression of Fas , FasL , Bcl 2 and Bcl XL at the protein level with monoclonal antibodies , using dual colour flow cytometry , and at the mRNA level in mononuclear cells by quantitative reverse transcriptase polymerase chain reaction . ^^^ Fas and FasL expression , both at the level of protein and of mRNA , was increased , whereas Bcl 2 expression was decreased both at the level of protein and of mRNA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / FasL interaction is not involved in apoptosis of activated CD4+ T cells upon HIV 1 infection in vitro . ^^^ In HIV 1 infected individuals , Fas expression and Fas / FasL mediated apoptosis of mature T cells are known to increase compared with those in normal individuals . ^^^ To elucidate a relation between acute HIV 1 infection and the regulation of Fas / FasL system upon T cell activation , resting CD4+ T cells were acutely infected or uninfected with HIV 1 and subsequently activated by phorbol myristate acetate and ionomycin ( PMA / IM ) . ^^^ Four days after infection , when HIV 1 env gp 120 is expressed in more than one half of activated T cells , Fas / FasL expression was analyzed by flow cytometry , and apoptosis inducing activity of these activated primary CD4+ T cells on Fas+ Jurkat cells was examined . ^^^ The level of Fas or FasL expression was not altered during acute HIV 1 infection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The T cell response following antigen engagement may therefore be influenced by the relative expression levels of these coreceptors as well as by the availability of their ligands ( CD80 / 86 and Fas L ) . ^^^ Since antigen presenting cells may express Fas L under certain circumstances , the maintenance of T cell CD 28 expression may be crucial for the prevention of Fas mediated apoptosis during the course of antigen engagement . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
AIDS KS cells expressed fas , bcl 2 , and bcl xL genes but lacked fasL and bax gene expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Antiinflammatory effects of CD 95 ligand ( FasL ) induced apoptosis . ^^^ In immune privileged sites such as the eye , CD 95 ligand ( FasL ) induced apoptosis controls dangerous inflammatory reactions that can cause blindness . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this study we analysed effects of proinflammatory cytokines on Fas / Fas ligand ( FasL ) induced synovial cell apoptosis , and evaluated apoptosis associated protein expression in the synovial cells in patients with RA . ^^^ RA synovial cells expressed Fas antigen and lymphocytes infiltrating into RA synovium expressed FasL . ^^^ Thus , we found that although RA synovial cells could die via apoptosis through Fas / FasL pathway , apoptosis of synovial cells was inhibited by proinflammatory cytokines present within the synovium . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The function of the Fas / FasL system in the dampening of immune responses to infectious agents through the autocrine deletion of activated T cells has been well documented . ^^^ In this review , we focus on the role of the interaction of Fas and FasL in the modulation of antitumor responses . ^^^ By reviewing data that we have generated in our laboratory as well as reports from the literature , we will argue that the Fas / FasL system is a generalized mechanism used in an autocrine fashion to regulate cell survival and expansion in response to environmental and cellular cues . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We examined whether myocardial cell death occurs via apoptosis in myosin induced autoimmune myocarditis in rats and whether the Fas / Fas ligand ( FasL ) system plays a role in this apoptosis . ^^^ Some rats were injected with anti Fas Ab ( 0 . 1 mg / kg ) or anti FasL Ab ( 0 . 1 mg / kg ) , and subsequently , inflammatory lesions exhibited less severe than did untreated rats with myocarditis . ^^^ These findings suggest that cell death via apoptosis of cardiomyocytes and lymphocytes is one of the mechanisms of myocardial injury in autoimmune myocarditis , and that the Fas / FasL system might play a role in the induction of this apoptosis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
HIV / gp120 and PMA / ionomycin induced apoptosis but not activation induced cell death require PKC for Fas L upregulation . ^^^ Gp 120 apoptosis occurs by induction of Fas L and subsequent triggering of the Fas apoptotic pathway . ^^^ Here , through the use of several compounds inhibiting induction of Fas L , we show that , in a Th 1 clone , a protein kinase C ( PKC ) independent pathway activated by TCR stimulation is distinguishible from a PKC dependent pathway activated by either phorbol 12 myristate 13 acetate ( PMA ) / ionomycin or asynchronous stimulation of TCR and CD 4 as occurs in gp 120 apoptosis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the present study , the expression of TNF , LT alpha ( the soluble form of LT ) , LT beta ( the beta chain of LT alpha beta , the membrane bound form of LT ) , TNF RI , TNF RII , LT beta R , FasL , and Fas receptor in MS lesions has been examined by immunohistochemistry for protein and by RT PCR for mRNA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunohistochemistry revealed that p 53 , fas , and fasL , but not bcl 2 were highly expressed in the target tissues of KCS dogs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Fas ligand ( FasL ) deregulated apoptosis and IL 6 insensitivity in highly malignant myeloma cells . ^^^ Here we explore its role in the spontaneous and Fas / FasL regulated apoptosis of seven myeloma cell clones ( MCC ) . ^^^ MCC 2 and 7 were constitutively defective in Fas antigen in the presence of large membrane exposure of FasL , and showed a high rate of cell proliferation irrespective of the presence of IL 6 . ^^^ Both [ 3 ( 4 , 5 dimethylthiazol 2 yl ) 2 , 5 diphenyl tetrazolium bromide ] ( MTT ) cytotoxicity assay and PI staining of WC 8 lymphoblasts from a Fas transfected mouse lymphoma , incubated with supernatants from MCC , showed a variable cytocidal property , thus confirming the cellular release of FasL . ^^^ However , a significant elevation of FasL secretion occurred in both Fas MCC , whereas molecular cloning and sequencing of Fas revealed the presence of a splicing variant , namely Fas Exo 4 , 6Del , in the cDNA from both MCC 3 and 5 , which were previously demonstrated to be unresponsive to Fas stimulation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We studied the apoptotic cascade in this complex epithelial layer by immunohistochemical localization of Fas , FasL , Bcl 2 , Mcl 1 , pro caspase 3 and caspase 3 , T cell restricted intracellular antigen related protein ( TIAR ) , poly ( ADP ribose ) polymerase ( PARP ) , lamin B , topoisomerase IIalpha , and transglutaminase 2 in cryostat and paraffin fixed tissue sections from normal human first trimester and term placental villi . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Previously , we had demonstrated that thymineless death involved signaling via Fas / FasL interactions . ^^^ However , in the presence of oncogenic K Ras , survival did not involve down regulation of Fas or FasL expression but did involve members of the Bcl 2 family . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To examine the role of the Fas ligand / Fas ( FasL / Fas ) system and apoptosis in renal allograft rejection , we analyzed FasL / Fas expression and apoptosis in 63 renal allograft biopsy specimens obtained from 56 renal transplant recipients in Tokyo , Japan . ^^^ The mean number of Fas positive tubular epithelium was significantly higher in biopsy specimens with AR than in those with NR , but FasL expression was highly expressed in infiltrating lymphocytes in the interstitium of allografts with cellular rejection . ^^^ Thus , Fas expression on epithelial cells might actively trigger their apoptosis by the interaction between Fas and FasL . ^^^ Studies of human normal renal derived cell lines ( RPTEC 2601 [ epithelial ] and NHMC 5155 [ mesangial ] ) showed that both constitutively expressed Fas ( but not FasL ) mRNA . ^^^ This suggested that AR might be associated with increased apoptosis in the renal tubular epithelial cells mediated by the Fas / FasL system . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Signals generated via HLA DR result in upregulation of tumor necrosis factor alpha ( TNF alpha ) and nitric oxide as well as an enhanced expression of Fas and its natural ligand ( Fas L ) , all molecules associated with programmed cell death ( apoptosis ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
C3H Fasl ( gld ) ( FasL ) mutant mice , suggesting that T cells can actively eliminate hepatic NK cells through a Fas dependent mechanism . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) prevents activation induced cell death : IL 2 independent inhibition of Fas / fasL expression and cell death . ^^^ Triggering of the TCR / CD3 complex with specific antigen or anti CD 3 monoclonal antibody initiates activation induced cell death ( AICD ) in mature T cells , an effect also mediated by the Fas / FasL system . ^^^ We have previously shown that CD 2 stimulation rescues T cells from TCR / CD3 induced apoptosis by decreasing the expression of Fas and FasL . ^^^ The results indicated that transcription of Fas / FasL is controlled by interleukin 2 ( IL 2 ) production and that CD 2 triggering rescues a T cell hybridoma from AICD via decreased production of IL 2 . ^^^ To ascertain whether modulation of IL 2 may be a general mechanism of AICD control , we examined other stimuli , capable of modulating the expression of the Fas / FasL system and the ensuing AICD , for ability to affect production of IL 2 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( CD 95 / APO 1 ) is a death receptor that initiates an apoptotic signal when activated by its ligand , FasL . ^^^ Normal vascular endothelial cells are resistant to Fas mediated apoptosis though they express both Fas and FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas and / or FasL positive cells , including lymphocytes and histiocytes , were frequently encountered in the necrotizing lesions , however , they were rare in the nonpathological regions . ^^^ In double staining , CD 8 positive lymphocytes occasionally expressed Fas and / or FasL , and histiocytes also expressed FasL and / or Fas . ^^^ However , CD 4 positive lymphocytes rarely expressed FasL and / or Fas . ^^^ In a flow cytometric analysis , most of the cytotoxic T cells , which were recognized by cytolytic granules of TIA 1 and considered to be CD 8 positive lymphocytes , expressed FasL and Fas . ^^^ The perforin positive lymphocytes also expressed FasL and Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activated BM T cells induced Fas dependent cytotoxicity of ME 25 insofar as blocking anti FasL MoAb inhibited the killing of ME 25 induced by activated BM T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recent studies have shown that the Fas / Fas ligand ( FasL ) system is a key factor controlling apoptotic cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Macrophages and T lymphocytes infiltrate the wall of abdominal aortic aneurysms ( AAAs ) and produce death promoting proteins ( perforin , Fas , and FasL ) . ^^^ Macrophages and T lymphocytes infiltrate the wall of AAAs , where they can produce cytotoxic mediators such as cytokines , perforin , and Fas / FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although autocrine / paracrine Fas Fas ligand ( FasL ) interaction is responsible for thyrocyte cell death during the active phases of HT , the role of infiltrating T lymphocytes ( ITL ) in this process is still unknown . ^^^ Therefore , we investigated the expression and function of Fas and FasL in ITL . ^^^ These data demonstrate that ITL are not directly involved in thyrocyte cell death during HT , suggesting that autocrine / paracrine Fas FasL interaction is a major mechanism in autoimmune thyrocyte destruction . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas / Fas ligand ( FasL ) system plays an important role in the induction of lymphoid apoptosis and has been implicated in the suppression of immune responses . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Analysis of possible mechanisms of induction of apoptosis does not support Fas and Fas L as having a main role but points instead to Bcl 2 and Bax . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
There was also a decline in the expression of Fas L and Fas R in the pachytene spermatocytes and spermatids . ^^^ Fas R was also present in Sertoli cells , although Fas L staining was minimal . ^^^ As the colocalization of Fas L and Fas R correlates with the germ cell types that die in response to androgen withdrawal , the potential exists for apoptosis in the rat spermatogenic epithelium to be regulated by the Fas pathway . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas FasL interaction involved in pathogenesis of ocular toxoplasmosis in mice . ^^^ The intent of this study was to investigate the role of Fas FasL interaction in a murine model of acquired ocular toxoplasmosis induced by intracameral inoculation of Toxoplasma gondii . ^^^ Intraocular inflammation , Fas and FasL expression on lymphocytes and on ocular tissues , the occurrence of apoptosis , and the frequency of CD 8 ( + ) and CD 4 ( + ) T cells in the infected eyes were analyzed in C57BL / 6 ( B 6 ) mice . ^^^ Susceptibility to parasite induced intraocular inflammation was observed in Fas deficient ( B 6 lpr ) and FasL deficient ( B 6 gld ) mice . ^^^ Inoculation of 5 , 000 T . gondii tachyzoites induced significant intraocular inflammation associated with increase of Fas and FasL expression in the inoculated eyes of wild type B 6 mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In bystander lysis , the APC again induces FasL expression on the T cell , but the target is a third Fas positive cell that may lack the appropriate MHC restricting element to activate the T cell . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
On the role and significance of Fas ( Apo 1 / CD95 ) ligand ( FasL ) expression in immune privileged tissues and cancer cells using multiple myeloma as a model . ^^^ Our knowledge in immunology has been dramatically increased by several excellent investigations elucidating the role of the Fas ( Apo 1 / CD95 ) receptor / ligand ( FasL ) system in complex immunological processes such as the acquisition of self tolerance in T cells , progression of autoimmunity , clonal deletion of activated T cells , B cell regulation and the establishment of `` immune privileged ' ' sites such as testis or retina . ^^^ In addition to these regulatory immunological activities , Fas / FasL interaction was also shown to participate in active defense mechanisms of the host against infected or transformed cells thereby inducing apoptosis in target cells . ^^^ The FasL molecule is functionally active and able to induce programmed cell death in Fas sensitive target T cells in vitro . ^^^ These target T cells were protected from programmed cell death by preincubation of T cells with a Fas blocking monoclonal antibody ( mAb ) or of myeloma cells with a FasL neutralizing mAb . respectively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here , we investigate whether the M . avium induced protection of NOD mice from diabetes was associated with changes in the expression of Fas ( CD 95 ) and FasL by immune cells , as well as alterations in cytotoxic activity , interferon gamma ( IFN gamma ) and IL 4 production and activation of T cells of infected animals . ^^^ Our data indicate that protection of NOD mice from diabetes is a Th 1 type response that is mediated by up regulation of the Fas FasL pathway and involves an increase in the cytotoxicity of T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas Fas ligand ( FasL ) system has been implicated in maintaining the immune privileged nature of the testis . ^^^ The present report concerns the role of the Fas FasL system in regulating germ cell apoptosis , another important function of this system in the human testis . ^^^ The present results suggest an important role for the Fas FasL system in the regulation of germ cell apoptosis in the human testis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Surprisingly , we found that thymic negative selection was impaired in the absence of Fas , but not FasL , molecule expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
USA , 94 : 8144 8149 , 1997 ) that thymineless death in thymidylate synthase deficient ( TS ) colon carcinoma cells is mediated via Fas / FasL interactions after deoxythymidine ( dThd ) deprivation , and that Fas dependent sensitivity of human colon carcinoma cell lines may be dependent upon the level of Fas expressed . ^^^ The cytotoxic activity of FUra / LV was inhibited by dThd in HT 29 cells and also , in part , by NOK 1+NOK 2 MoAbs that prevent Fas / FasL interactions . ^^^ FUra / LV induced cytotoxicity was significantly potentiated by IFN gamma , reversed by exposure to NOK 1+NOK 2 antibodies , and correlated with a 4 fold induction of Fas expression in the presence of IFN gamma and significant elevation in expression of FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We have studied Fas / Fas ligand ( FasL ) expression , which is involved in the cytotoxic activity , immune privilege , and self tolerance , and other apoptosis associated molecule expression of peripheral blood lymphocytes ( PBL ) in healthy subjects with / without cigarette smoking . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , no significant changes were detected in the expression of the mdm 2 , bcl 2 , bax , fas and fasl genes , suggesting the existence of other genes associated with apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Antiretroviral cytolytic T lymphocyte nonresponsiveness : FasL / Fas mediated inhibition of CD 4 ( + ) and CD 8 ( + ) antiviral T cells by viral antigen positive veto cells . ^^^ Because of the antigen specificity of the inhibition , these results collectively implicate a FasL / Fas interaction mechanism : viral antigen positive AKR . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this paper , we have further characterized the sensitive and resistant phenotypes and investigated whether a different expression of the apoptotic genes Fas , FasL , Bcl 2 , Bcl 10 and Bax is involved in the regulation of Dex mediated apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
One mechanism of T cell directed cell death is the interaction of FasL on the CD 8 ( + ) T lymphocytes and Fas expressed on the target cell . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The gene deletions included tumor necrosis factor ( TNF ) alpha , lymphotoxin , TNF receptor 1 or 2 , Fas L , inducible nitric oxide synthase , perforin , and interleukin1beta converting enzyme . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Genes showing efficacy in this way include these encoding interleukin ( IL ) 1Ra , IL 1sR , TNFsR , transforming growth factor beta ( TGF beta ) , IL 13 , Fas L , IL 10 and vIL 10 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The FasL in RCC is functional because in coculture experiments , FasL+ tumors induced apoptosis in Fas sensitive Jurkat T cells and in activated peripheral blood T cells but not in resting peripheral blood T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis mediated by Fas / FasL interaction plays an important role during many inflammatory skin disorders . ^^^ To estimate whether the expression of FasL , the ligand for Fas , might be regulated by cytokines we stimulated primary human keratinocytes with several pro and anti inflammatory cytokines . ^^^ In summary , our data suggest the important regulatory role of cytokine controlled Fas / FasL interaction in the cross talk between keratinocytes and skin infiltrating T cells for maintenance of homeostasis in inflammatory skin processes . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Chemotherapeutic drugs that damage DNA kill tumor cells , in part , by inducing the expression of a death receptor such as Fas or its ligand , FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The two major effector pathways of CTL killing which lead to apoptosis involve the Fas / Fas ligand ( Fas L ) lytic pathway , and the perforin / granzyme degranulation pathway . ^^^ The expression of CTL effector molecules which influence these pathways include Fas , Fas L and TiA 1 ( cytotoxic granule protein ) . ^^^ In the case of Fas L expression , there was little expression in all three biopsy groups , apart from one case of chronic rejection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( CD 95 ) , a member of the tumor necrosis factor receptor superfamily , and its ligand ( FasL ) , a tumor necrosis factor like protein , are intensely studied because their interaction on the cell surface is critical for the induction of programmed cell death ( apoptosis ) and the regulation of immune responses . ^^^ Fas ( CD 95 ) , a member of the tumor necrosis factor receptor superfamily , and its ligand ( FasL ) , a tumor necrosis factor like protein , are intensely studied because their interaction on the cell surface is critical for the induction of programmed cell death ( apoptosis ) and the regulation of immune responses . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
For both CD 4 ( + ) and CD 8 ( + ) T cells , the Fas pathway was found to play a major role in this AICD : alloreactive T cells upregulated Fas and FasL , and AICD of antihost T cells was much decreased in the case of lpr ( Fas deficient ) donors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Many tumour cells express both Fas and its ligand ( FasL ) on their surface and it has remained a mystery why such cells do not simply kill themselves . ^^^ It remains to be determined whether Fas and FasL are expressed in human hepatoblastomas and if so , what is responsible for the possible Fas resistance of these tumours . ^^^ In this study , the expression of Fas and FasL was examined in 23 cases of human hepatoblastoma by immunohistochemical staining . ^^^ Fas and FasL were expressed in all hepatoblastomas analysed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas / Fas ligand ( FasL ) system seems to play a key role in regulating immunoresponses . ^^^ These results indicate that Fas / FasL interactions are involved in the down regulation of IL 2 activated human NK cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Gamma interferon modulates CD 95 ( Fas ) and CD 95 ligand ( Fas L ) expression and nitric oxide induced apoptosis during the acute phase of Trypanosoma cruzi infection : a possible role in immune response control . ^^^ Furthermore , IFN gamma modulates an enhancement of Fas and Fas L expression after infection , since the infected IFN gamma ( / ) mice showed significantly lower levels of Fas and Fas L expression . ^^^ In the presence of IFN gamma and absence of NO , although Fas expression was maintained , apoptosis levels were significantly reduced but still higher than those found in splenocytes from uninfected mice , suggesting that Fas Fas L interaction could also play a role in apoptosis induction in T . cruzi infected mice . ^^^ Moreover , in vivo , the treatment of infected WT mice with the inducible nitric oxide synthase inhibitor aminoguanidine also led to decreased NO and apoptosis levels but not Fas expression , suggesting that IFN gamma modulates apoptosis induction by two independent and distinct mechanisms : induction of NO production and of Fas and Fas L expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Alteration of the Fas receptor ( Fas ) / ligand ( FasL ) system including soluble forms is regarded as one of the mechanisms preventing the immune system from rejecting the tumor cells . ^^^ However , less attention has been paid to the role of Fas / FasL interaction in vivo . ^^^ Therefore , we investigated the expression of Fas and FasL by immunohistochemistry and reverse transcription polymerase chain reaction ( RT PCR ) and measured the serum levels of soluble Fas ( sFas ) and FasL ( sFasL ) in 44 patients with hepatocellular carcinoma ( HCC ) . ^^^ In the noncancerous liver tissues , Fas expression was up regulated in most cases , and FasL expression was detected in 6 cases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Exposure to PMA alone did not induce Fas , Fas L , or apoptosis . ^^^ Cells exposed to mild UV B irradiation ( 80 J / m ( 2 ) ) alone exhibited a slight expression of Fas and Fas L 36 to 48 h after the exposure , and exhibited apoptosis as evidenced by DNA fragmentation 72 h after exposure . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A molecular model of the complex between Fas and its ligand was generated to better understand the location and putative effects of site specific mutations , analyze interactions at the Fas FasL interface , and identify contact residues . ^^^ Using the model , it was possible to map four of five N linked glycosylation sites in Fas and FasL and to study 10 of 11 residues previously identified by mutagenesis as important for binding . ^^^ The predicted structure of the Fas FasL interface was consistent with the experimentally established importance of these residues for binding . ^^^ Despite its limitations , the study provided a much improved basis to understand the role of Fas and FasL residues for binding compared to previous residue mapping studies using only a molecular model of Fas . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas / Fas ligand ( FasL ) system is involved in the induction of apoptosis in human thyrocytes . ^^^ The Fas / FasL system may play an important role in the regulation of cell number within the thyroid gland , and may be involved in the processes leading to goiter in iodine deficiency . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We propose that in breast cancer , tumor escape from immunological surveillance results from the induction of apoptosis of Fas bearing activated lymphocytes by FasL bearing breast cancer cells . ^^^ Our results suggest the breast tumors may elude immunological surveillance by inducing , via the Fas / FasL system , the apoptosis of activated lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The FasL Fas system regulates renal cell apoptosis , as well as the immune and inflammatory responses . ^^^ Evidence that FasL and Fas participate in renal injury may be summarized along modified Koch ' s postulates ( Table 1 ) : ( 1 ) FasL is expressed by renal cells and during renal injury , ( 2 ) activation of the Fas receptor promotes apoptosis of cultured renal cells , ( 3 ) Fas agonists induce glomerular injury but they may also decrease renal injury by limiting injurious immunological responses , ( 4 ) mice with disrupted FasL / Fas systems are protected from tubular cell injury during ischaemia reperfusion , although they develop autoimmune glomerulonephritis if other genetic predisposing factors are present . ^^^ FasL / Fas must be considered a new target for therapeutic intervention in renal injury . ^^^ Given the complexities of the FasL / Fas system , further studies are warranted . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Involvement of Fas / FasL system in the pathogenesis of autoimmune diseases and Wilson ' s disease . ^^^ The interaction of Fas with FasL has been demonstrated to be implicated in the pathogenesis of several autoimmune and liver diseases . ^^^ Recently , attention has been focused on the hypothesis that thyrocytes and beta cells undergo massive Fas / FasL mediated apoptosis during autoimmune response . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Therefore , in 46 gliomas ( including astrocytomas , oligodendrogliomas , oligo astrocytomas , and glioblastomas ) , the relationship of apoptosis and necrosis and the expression of apoptosis promoting ( p 53 , bax , Fas , Fas L ) and inhibiting ( bcl 2 ) factors as well as of different isoforms of NOS ( NOSb , NOSe , NOSi ) and manganese superoxide dismutase ( MnSOD ) were studied . ^^^ Glial tumour cells displayed upregulation of bax , Fas , Fas L , p 53 , and bcl 2 but with no significant correlation with malignancy . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
PROBLEM : The Fas / Fas ligand ( FasL ) system is discussed to be one of the main components responsible for the formation and maintenance of an immune privilege . ^^^ As we were able to detect FasL on fetal trophoblast cells infiltrating the maternal uterine tissue and Fas on decidual leukocytes ( Hammer et al . , Am J Reprod Immunol , 1999 ; 41 : 41 51 ) , we investigated whether apoptosis occurs in the maternal decidua during the first trimester of pregnancy . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and FasL enhancement is reported in rats with EMIU . ^^^ The eyes and draining lymph nodes were collected for histology , analyses of nitrite , peroxide , and superoxide dismutase , Fas and FasL immunochemistry , in situ hybridization for iNOS mRNA and in situ apoptosis detection at the peak of the disease . ^^^ There was mild enhancement of Fas and FasL in the eyes and lymph nodes of D 609 injected animals . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , Fas or FasL was only detected on the lymphocytes within the granuloma . ^^^ We conclude that P . acnes can induce a TNFalpha mediated acute hepatic apoptosis which subsequently progress to a T cell mediated granulomatous hepatitis with increased expression of multiple cytokines and Fas / FasL . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here we show for the first time that VK ( 3 ) induced apoptosis requires the Fas / FasL system . ^^^ Spleen cells from both Fas and FasL deficient mice ( C57BL / 6 lpr and C57BL / 6 gld , respectively ) had much lower levels of VK ( 3 ) apoptosis in vitro compared to cells from control C57BL / 6 mice . ^^^ VK ( 3 ) induced apoptosis in Jurkat cells , coincident with an increase in both Fas and FasL expression . ^^^ Furthermore , because VK ( 3 ) effects were inhibited by glutathione , a potent antioxidant , oxidative stress was linked to the Fas / FasL system . ^^^ Moreover , since the Jurkat cell lines were p 53 null , the activation of Fas / FasL system after oxidative stress apparently acted through a p 53 independent pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ficoll separated mononuclear cells from 18 bone marrow aspirate specimens obtained from 17 MDS patients , 4 normal healthy donors , and 3 acute myeloid leukemia patients transformed from MDS ( t AML ) were studied for mRNA expression of Fas L , Fas , and the effectors of their signaling , Caspase 1 and Caspase 3 , using reverse transcriptase polymerase chain reaction . ^^^ Fas L , Fas , and Caspase 1 were detectable in all of the samples in the three groups . ^^^ Treatment of MDS cells with anti Fas L antibody suppressed apoptosis ( AI % : 2 . 1 % + / 0 . 6 % in untreated vs . 1 . 37 % + / 0 . 5 % in treated , n = 6 , P = 0 . 02 ) , indicating functional participation of Fas signaling in MDS . ^^^ Further , it was found that Fas L , Fas , and Caspase 1 mRNA expression remained unchanged in 4 hours . ^^^ Furthermore , in tumor necrosis factor alpha ( TNF alpha ) treated HL 60 promyelocytic cells , a definite periodicity in the expression of different mRNAs was observed with upregulation of TNF alpha itself at 30 minutes , increased expression of Fas and the appearance of Fas L after 2 hours , and a decrease in Fap 1 expression after 8 hours . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
There is considerable interest in the role of Fas protein as it induces apoptotic cell death when ligated by its natural ligand ( FasL ) . ^^^ Interaction between Fas and FasL is a crucial mechanism for clonal deletion and immune tolerance and privilege , control of T cell expansion during immune responses and killing by cytotoxic T lymphocytes . ^^^ Recent studies have demonstrated that the Fas / FasL system is implicated in the pathogenesis of several human diseases ranging from AIDS to autoimmunity and lymphoproliferation , hepatitis , multiple sclerosis and transplant rejection . ^^^ It is conceivable that modulating the activity of the Fas / fasL pathway would have clinical applications for the treatment of these patients . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and FasL were expressed consistently in ocular resident cells of EMIU , but were elevated in EAU . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
One of these pathways employs the death receptor Fas and its ligand ( FasL ) . ^^^ Fas expression and death pathway signaling have been demonstrated in the thyroid , but there is controversy surrounding the expression of FasL and its role in thyroid autoimmunity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To our knowledge , this is the first report that Fas mediates apoptosis in LEC , suggesting that apoptosis of these cells may participate in the liver damage observed in animals after receiving anti Fas mAb or soluble FasL . ^^^ Our findings also suggest that the Fas / FasL system may transduce activating signals independently of cell death in LEC 1 . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Death receptors for FasL ( Fas ) and for TRAIL ( DR 4 , DR 5 ) are emerging as important regulators of drug induced apoptosis in human cancers , mediated by caspase activation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although almost all leukemic cells express the 37 kD form of FasL , only 54 % of acute myeloblastic leukemia and 27 % of chronic myeloid leukemia ( CML ) cells bore a FasL with killing properties , as assessed by the ability of leukemic cells to cause the apoptosis of a Fas sensitive target cell line or autologous activated T cells in 3 tested leukemic cases . ^^^ Experiments with a recombinant Fas Fc molecule confirmed the role of Fas / FasL in leukemic mediated cell death . ^^^ Thus , myeloid leukemic cells from some , but not all patients can set up a mechanism of immune escape involving the Fas / FasL pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVES : In order to investigate the effect of preoperative interferon ( IFN ) alpha on Fas / Fas ligand ( FasL ) system , we examined Fas and FasL expression and the occurrence of apoptotic cell death in a preoperative therapy group , and in a control group using surgically resected renal cell carcinoma ( RCC ) tissues . ^^^ Immunohistochemistry for Fas and FasL , and terminal deoxynucleotidyl transferase ( TdT ) mediated digoxigenin dUTP nick end labeling ( TUNEL ) were employed . ^^^ We defined the labeling index ( LI ) as percentage of Fas or FasL positive cells in carcinomatous cells , and apoptotic index ( AI ) as percentage of TUNEL positive cells in carcinomatous cells . ^^^ CONCLUSION : These data suggest that apoptosis via the Fas / FasL system is functional , and that preoperative IFN alpha treatment may up regulate the Fas / FasL system in RCC . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Embryonic motoneurons coexpress the death receptor Fas and its ligand FasL at the stage at which PCD is about to begin . ^^^ Most ( 75 % ) of these were saved by Fas Fc receptor body , which blocks interactions between Fas and FasL , or by the caspase 8 inhibitor tetrapeptide IETD . ^^^ Therefore , activation of Fas by endogenous FasL underlies cell death induced by trophic deprivation . ^^^ In the presence of neurotrophic factors , exogenous Fas activators such as soluble FasL or anti Fas antibodies triggered PCD of 40 50 % of purified motoneurons over the following 3 5 d ; this treatment led to activation of caspase 3 , and was blocked by IETD . ^^^ Levels of Fas expressed by motoneurons varied little , but FasL was upregulated in the absence of neurotrophic factors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis was identified as a key mechanism of keratinocyte death , and appeared independent of the FAS / FAS ligand ( FAS L ) pathway , as epidermal expression of FAS was not increased compared with normal skin , and FAS L was undetectable on the protein and mRNA level . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas Fas ligand ( Fas FasL ) interactions play a critical role in the effector function of the CTL killing . ^^^ In this study we investigated the role of Fas FasL interactions in CTL effector functions in vivo in mouse lung . ^^^ The in vivo role of the Fas FasL interactions was determined by adoptive transfer of splenocytes from normal immune competent mice to Fas deficient mice ( B 6 lpr ) ; likewise , the function of FasL on CTLs was analyzed by the ability of splenocytes from FasL deficient mice ( B 6 gld ) to eliminate transgene expression in Rag 1 deficient mice . ^^^ These studies demonstrate that despite expression of Fas and FasL in bronchioepithelial cells and CTLs , these interacting molecules do not play a critical role in elimination of transgene expression in the lung . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Fas ligand ( FasL ) system , a major regulator of apoptosis , is involved in cancer cell death induced by the immune system and anticancer drugs . ^^^ The former induces apoptosis by ligation of FasL or agonistic anti Fas antibody , whereas the latter inhibits Fas mediated apoptosis by neutralizing its ligand . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The destruction of epithelial cells of Sjgren ' s syndrome patients is probably due to activation of several apoptotic pathways since epithelial cells express different apoptosis related molecules such as Fas , FasL , Bax , while mononuclear cells express Bcl 2 , Perforin and Granzymes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
For successful active specific immunization against human cancers the understanding of the immunoevasive maneuvers of the tumor cell ( through FasL > Fas ; TRAIL ; CD40L > CD 40 ; TGFbeta etc . systems ) is essential . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas / Fas ligand ( FasL ) pathway is involved in a variety of regulatory mechanisms that could be important for the development of graft vs host disease ( GVHD ) after bone marrow transplantation ( BMT ) , such as cytolysis of target cells by cytotoxic T cells , regulation of inflammatory responses , peripheral deletion of autoimmune cells , costimulation of T cells , and activation induced cell death . ^^^ To further evaluate the role of Fas / FasL in the complex pathophysiology of GVHD , we used Fas deficient B6 . lpr mice as recipients in a MHC matched minor histocompatibility Ag mismatched murine model for GVHD after allogeneic BMT ( C3H . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Both Tc 1 and Tc2 / 0 clones showed comparable cytotoxicity and produced similar levels of perforin and Fas L . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activation of Fas by FasL induces apoptosis by a mechanism that can not be blocked by Bcl 2 or Bcl 10 ( L ) . ^^^ Comparison between physiological ligand and anti Fas antibodies revealed that only extensive Fas aggregation , by membrane bound FasL or aggregated soluble FasL consistently triggered apoptosis , whereas antibodies could act as death agonists or antagonists . ^^^ In contrast , Bcl 2 or Bcl 10 ( L ) did not block FasL induced apoptosis in lymphocytes or hepatocytes , demonstrating that signaling for cell death induced by Fas and the pathways to apoptosis regulated by the Bcl 2 family are distinct . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas was generally overexpressed in cells freshly isolated from SLE patients but the apoptotic response to FasL was normal . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Dysregulation of apoptosis , particularly in the Fas / Fas ligand ( FasL ) pathway , is considered to be involved in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus ( SLE ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In parallel , the expressions of Fas and its ligand ( FasL ) were analyzed by immunocytochemical staining and Western blot hybridization . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Blockage of apoptosis and necrosis could be further increased by adding anti Fas ligand ( FasL ) antibody , suggesting that induction of apoptosis via FasL and Fas receptor ( Apo 1 / CD95 ) may also play a role . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Central nervous system ( CNS ) Fas and FasL mRNA levels in wild type SJL ( H 2 ( s ) ) mice peaked just before spontaneous disease remission and gradually declined as disease remitted . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Significantly , As ( 2 ) O ( 3 ) induced apoptosis of HL 60 / Bcr Abl and K 562 cells was associated with a decline in Bcr Abl protein levels , without any significant alterations in the levels of Bcl 10 ( L ) , Bax , Apaf 1 , Fas , and FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We examined Fas Fas ligand ( FasL ) interactions in donor and host haematopoietic cells over a prolonged period of parental induced GVHD . ^^^ Furthermore , injection of IFN gamma gene knockout ( gko ) B 6 spleen cells failed to augment Fas and FasL expression in recipient mice , resulting in a failure of donor cell engraftment . ^^^ This suggests that the induction of apoptosis by Fas FasL interactions in host cells may contribute to a reconstitution of the host with donor cells and that donor derived IFN gamma plays a significant role for Fas FasL interactions in host cells during parental induced GVHD . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Drug induced apoptosis in lung cnacer cells is not mediated by the Fas / FasL ( CD95 / APO1 ) signaling pathway . ^^^ Recently , a role for the Fas / FasL ( CD95 / Apo1 ) signaling system in chemotherapy induced apoptosis was proposed in some cell types . ^^^ In the present work , the involvement of the Fas / FasL system in drug induced apoptosis in lung cancer cells was investigated upon exposure to four cytotoxic drugs ( cisplatin , gemcitabine , topotecan , and paclitaxel ) . ^^^ We assessed the expression of Fas and FasL and the function of the Fas pathway in six lung cancer cell lines ( H 460 , H 322 , GLC 4 , GLC4 / ADR , H 187 , and N 417 ) . ^^^ All lung cancer cell lines expressed Fas and FasL at RNA and protein levels , and apoptosis could be induced in four of six cell lines upon exposure to the Fas agonistic monoclonal antibody ( mAb ) CLB CD95 / 15 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Lysis requires direct cell : cell interaction between the gamma delta + cell and CD4+ Th 2 target and is most likely mediated through Fas : FasL interaction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas / Fas ligand ( FasL ) pathway has been shown to be important in T lymphocyte mediated cell death and is a key peripheral immunoregulatory mechanism that limits expansion of antigen activated lymphocytes . ^^^ The expression of Fas by commonly transplanted organs such as the heart , lung , kidney , and liver suggests that these tissues may be targets of FasL expressing allospecific cytotoxic T lymphocytes . ^^^ In this review the current literature examining the Fas / FasL system as a potential cellular effector pathway in tissue injury is discussed . ^^^ In addition to a deleterious role in destruction of graft tissue , Fas / FasL interactions may have a beneficial role in transplantation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The activity is not affected by neutralizing antibodies against regulatory cytokines , does not depend on Fas or FasL , and is not due to the presence of gangliosides . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We have previously shown that this luteolytic action of PRL is mediated by the Fas / Fas ligand ( FasL ) system . ^^^ P 4 significantly decreased the expression of mRNA of Fas , but not FasL , in cultured luteal cells prepared from both proestrous and mid pseudopregnant rats . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Role of Fas FasL interactions in the pathogenesis and regulation of autoimmune demyelinating disease . ^^^ Thus , T cell mediated Fas FasL interactions could directly contribute to the pathology of EAE and MS . ^^^ This review summarizes studies from our laboratory and others that implicate Fas FasL interactions in both the pathogenesis and regulation of demyelinating diseases . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Gammadelta T cells in both spleen and CNS expressed higher levels of the IL 2rbeta ( CD 122 ) , as well as Fas and FasL , than alphabeta T cells , suggesting that these cells function as immunoregulatory T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Transient apoptosis elicited by insulin in serum starved glioma cells involves Fas / Fas L and Bcl 2 . ^^^ In contrast , the expression of fas L gene in glioma cells remained constant . ^^^ When the expression of Fas L in U 373MG cells was suppressed by ribozyme , the insulin elicited transient apoptosis vanished . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Growth of FasL bearing tumor cells in syngeneic murine host induces apoptosis and toxicity in Fas ( + ) organs . ^^^ In the current study , we investigated whether the growth of FasL bearing tumor cells would induce apoptosis and toxicity in organs that express high level of Fas . ^^^ Furthermore , the soluble FasL was functional inasmuch as the sera from tumor bearing mice were able to induce apoptosis in Fas ( + ) but not Fas ( ) targets . ^^^ Together , these data suggested that the in vivo growth of FasL bearing tumor cells can induce significant apoptosis and toxicity in Fas ( + ) tissues of the host . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This mechanism normally operates in healthy individuals through CD 40 L / FAS L expressing activated T cells and is fundamental in the deletion of harmful B cells . ^^^ Analyzing the role of FAS / FAS L mediated apoptosis in lymphomagenesis , we purified B and T cells from low and high grade MALT B cell tumors and tonsillar memory B cells as control . ^^^ T cells were stimulated in vitro to express CD 40 L and FAS L using anti CD 3 antibodies and were subsequently cocultivated with B cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immature B cells in bone marrow express Fas / FasL . ^^^ Here we demonstrate the expression of Fas in immature B lymphocytes ( CD10 / CD19+ / CD40+ / sIg+ ) , and the presence of Fas natural ligand ( FasL ) in CD19+ bone marrow cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These cells also express the Fas ( APO 1 , CD 95 ) / FasL system , but are resistant to FasL induced apoptosis . ^^^ Bosentan sensitization to FasL induced apoptosis was not mediated by increased expression of Fas receptor and was blocked by the caspase inhibitor zVAD fmk . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recent studies have revealed that a variety of malignant tumors express Fas and / or its ligand FasL . ^^^ However , tumor cells expressing Fas are not always susceptible to Fas mediated cell death , and the biological significance of simultaneous expression of Fas and FasL in the same tumor is not known . ^^^ In the present study , we addressed this question in three glioma cells lines , A 172 , T98G , and YKG 1 , which express both Fas and FasL endogenously and their Fas transfectants . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To find whether Fas / Fas ligand ( FasL ) pathway is involved in T 2 toxin ( T 2 ) mediated thymocyte apoptosis , we used lpr / lpr ( lpr ) and gld / gld ( gld ) mice , whose Fas and FasL proteins , respectively , are functionally deficient . ^^^ These results strongly suggest that T 2 induced thymocyte apoptosis in vivo in mice is independent of the Fas / FasL pathway . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas FasL system plays a crucial role in the maintenance of homeostasis in the immune system . ^^^ To characterize the Fas / FasL system in macaque monkeys that are commonly used as experimental primates , we cloned and sequenced Fas cDNA derived from the cynomolgus monkey . ^^^ An agonistic Fas antibody ( CH 11 ) or cynomolgus FasL induced apoptosis in human Fas transfected K 562 cells in the presence of CHX but not in the cynomolgus Fas transfectant . ^^^ CH 11 and FasL failed to trigger apoptosis in the transfectant expressing human cynomolgus chimera Fas consisting mostly of human derived extracellular region and cynomolgus derived intracellular portion . ^^^ On the other hand , the transfectant expressing cynomolgus human chimera Fas with human derived intracellular region underwent apoptosis upon exposure to FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The apoptosis inducing Fas receptor has been shown to be down regulated in various types of tumors , while its ligand ( FasL ) appears to be frequently up regulated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas / Fas ligand ( FasL ) interaction between antigen presenting cells and T cells regulates the apoptosis of the former cells triggered by the latter cells . ^^^ We investigated the potential role of Fas / FasL interaction between thyrocytes and CD4+ T cells in the induction of Fas mediated apoptosis of the former cells induced by the latter cells . ^^^ In addition , a significant cytotoxicity of purified CD4+ T cells toward IFN gamma stimulated thyrocytes in the presence of SEB was induced , and the addition of anti HLA DR and DQ monoclonal antibodies ( mAbs ) or blockade of the Fas / FasL interaction reduced this cytotoxicity . ^^^ Our results suggest that 1 ) CD4+ T cells were activated by thyrocytes expressing MHC class 2 molecules in an SEB dependent manner and then expressed FasL . 2 ) These activated FasL+ CD4+ T cells killed thyrocytes by interacting with Fas on thyrocytes and FasL on activated CD4+ T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
PRL induced apoptosis in CL is mediated by the Fas / Fas ligand ( FasL ) system . ^^^ Fas mRNA was detected only in the luteal steroidogenic cells , and FasL mRNA was expressed only by the non steroidogenic CD 3 positive luteal immunocytes . ^^^ Thus , FasL expressing non steroidogenic luteal immunocytes are required for PRL induced luteal cell apoptosis and heterogeneous induction of apoptosis by Fas / FasL in CL . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Whereas previous studies were performed on ex vivo cultures or on peripheral blood , our investigations included in vivo analysis of IM tonsillectomy specimens ( 14 cases ) by in situ hybridization for viral RNA ( EBERs ) combined with immunohistochemistry ( IHC ; CD 3 , CD45RO , CD 20 , CD79a , Ki 67 , Bcl 2 , Bax , Fas , FasL ) and the TUNEL method . ^^^ Through altered expression of Bcl 2 / Bax and Fas / FasL , the activated T cells are subject to enhanced apoptosis while residing within the lymphoid tissue , which eventually allows the efficient silencing of this potentially damaging T cell response . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A higher proportion of mouse salivary gland cells bearing Fas was found in the aged group , whereas no significant changes were seen on tissue infiltrating CD 4 ( + ) T cells bearing FasL in the salivary glands from young and aged mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Regulation of Fas and FasL expression on rat Schwann cells . ^^^ In analogy with other immune protected sites , participation of the apoptosis inducing Fas / FasL molecules could play an important role . ^^^ To assess the possible involvement of the Fas / FasL system in T cell apoptosis in the PNS of the rat , we characterized Fas and FasL expression on neonatal rat Schwann cells ( SC ) in vitro . ^^^ These findings are in accord with recently published results showing Fas and FasL expression on malignant human cells , derived from brain tumors and upregulation of FasL on astrocytes after exposure to IFN gamma and TNF alpha . ^^^ We suggest that Fas / FasL expression on SC may contribute to the elimination of invading autoreactive T cells in the PNS in concert with other immune defense mechanisms . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cleavage of membrane bound FasL to a soluble form ( sFasL ) does not affect its ability to bind to Fas but drastically decreases its cytotoxic activity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Coexpression of Fas / FasL and Bax on brain and infiltrating T cells in the central nervous system is closely associated with apoptotic cell death during autoimmune encephalomyelitis . ^^^ To elucidate the molecular mechanism of apoptosis of infiltrating T and other cells occurring in the CNS during autoimmune encephalomyelitis , we determined the type of apoptotic cells and the localization of apoptosis related molecules ( Fas , FasL , Bax , Bcl 2 and active caspase 3 ) by immunohistochemistry . ^^^ Staining for apoptosis related molecules revealed that infiltrating T cells and microglia / macrophages , but not astrocytes and neurons , expressed both Fas FasL and Bax . ^^^ These findings suggest that coexpression of Fas / FasL and Bax is closely associated with apoptotic cell death of infiltrating T cells and microglia in the CNS . ^^^ Furthermore , astrocytes which express Fas and FasL , but not Bax , may play an important role in regulating inflammation in the CNS by inducing apoptotic cell death of infiltrating T cells and microglia , both of which have an inflammation promoting nature . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In thymidylate synthase deficient ( TS ) colon carcinoma cells , thymineless death is mediated via Fas / Fas ligand ( FasL ) interactions after thymidine deprivation and inhibited by the Fas inhibitory monoclonal antibody NOK 1 . ^^^ A close correlation was found between acute induction of apoptosis ( 24 h ) and up regulated expression of FasL at high concentrations of each of the three agents ( 0 . 3 3 microM doxorubicin , 0 . 3 3 microM topotecan , and 10 90 microM VP 16 ) , which was caspase dependent but Fas independent . ^^^ At nanomolar drug concentrations , prolonged arrest of TS cells in G 2 M phase resulted in the up regulation of FasL expression and the delayed appearance of apoptotic cells ( 6 days ) , which could also be inhibited by the general caspase inhibitor Z VAD FMK , but not by NOK 1 or Fas Fc . ^^^ This was in contrast to the Fas dependent regulation of thymineless death , which could be inhibited by blocking Fas / FasL interactions . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : Histologic sections from the left and right ventricles of 16 hearts with impending myocardial infarction were stained with terminal deoxynucleotidyl transferase mediated deoxyuridine 5 triphosphate nick end labeling ( TUNEL ) method and with antibodies to p 53 , bcl 2 , cpp 32 , FAS , FAS L , and bax . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : Activation of Fas ( CD 95 ) by its ligand ( FasL ) rapidly induces cell death through recruitment and activation of caspase 8 via the adaptor protein Fas associated death domain protein ( FADD ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We have previously shown that the androgen independent prostate cancer cells DU 145 , despite expressing Fas and FasL , were resistant to anti Fas induced apoptosis , and that this resistance could be overcome by pretreating the cells with sublethal doses of camptothecin . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We report that gastric T cells contribute to apoptosis of the epithelium by a Fas / Fas ligand ( FasL ) interaction . ^^^ Gastric T cell lines were also shown to express FasL , as evidenced by reverse transcription PCR and killing of target cells expressing Fas receptor . ^^^ Moreover , these T cell lines were capable of killing cultured gastric epithelial target cells and antibodies that block the interaction between Fas receptor and FasL inhibited this cytotoxic activity . ^^^ These observations demonstrate that local Th 1 cells may contribute to the pathogenesis of gastric disease during H . pylori infection by increasing the expression of Fas on gastric epithelial cells and inducing apoptosis through Fas / FasL interactions . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here we report that IFN alpha stimulation of PBMC from healthy donors induces Fas ( CD 95 ) ligand ( FasL ) transcription and leads to increased cell surface FasL expression exclusively on the NK cell fraction . ^^^ Furthermore , IFN alpha augments the FasL mediated cytotoxicity of normal PBMC against Fas sensitive lymphoid tumor cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To clarify the role of the Fas Fas ligand ( FasL ) system in the peripheral blood from patients with various renal diseases , the Fas and FasL expression on mononuclear cells ( MNCs ) and serum levels of soluble Fas ( sFas ) and soluble FasL were investigated . ^^^ Fas expression on MNCs was analyzed by a FACScan , sFas and soluble FasL were measured with an ELISA kit , and FasL expression on MNCs was counted using a FACScan after a bioassay . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
FasL binds preassembled Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 95 ligand ( FasL ) mRNA was detected in both immature and mature DC of each subset . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
FasL is an inducer of apoptosis ; it binds Fas and results in programmed cell death ( apoptosis ) of Fas bearing cells such as T lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of FasL and Fas protein and their soluble form in patients with hypersensitivity pneumonitis . ^^^ The Fas Fas ligand ( FasL ) system is one of the representative systems of apoptosis signaling receptor molecules , and is involved in various inflammatory diseases . ^^^ We hypothesized that the Fas FasL system may be associated with this disorder . ^^^ METHODS : We examined the expression of FasL and Fas proteins in lung tissues from patients with HP using immunohistochemistry . ^^^ RESULTS : FasL was detected in infiltrating mononuclear cells , and Fas was detected in infiltrating mononuclear cells , alveolar macrophages , and epithelioid cells in HP , whereas FasL was not detected and Fas was detected in few alveolar macrophages in controls . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( CD95 / APO 1 ) is a cell surface `` death receptor ' ' that mediates apoptosis upon engagement by its ligand , FasL . ^^^ FasL expressing colon tumor derived cell lines can trigger Fas mediated apoptosis of cocultured T cells in vitro . ^^^ FasL may also facilitate metastatic colonization of Fas sensitive organs such as the liver , by inducing apoptosis of target organ cells . ^^^ By contrast , colon tumor derived cell lines are usually resistant to induction of Fas mediated apoptosis , and colon cancer cells frequently coexpress Fas and FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : The Fas / Fas ligand ( FasL ) pathway plays an important role in a number of apoptotic processes that could be important for the development of graft versus host disease ( GVHD ) after bone marrow transplantation ( BMT ) , such as cytolysis of target cells by cytotoxic T cells , regulation of inflammatory responses , peripheral deletion of autoimmune cells , costimulation of T cells , and activation induced cell death . ^^^ METHODS : To study the role of the Fas / FasL pathway in the complex pathophysiology of graft versus host disease ( GVHD ) , we used FasL deficient B6 . gld mice as recipients in a Major Histocompatibility Antigen Complex matched minor Histocompatibility Antigen mismatched murine model for GVHD after allogeneic BMT ( C3H . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : In situ hybridization was carried out by using labeled RNA probes of fas , fasL , and bcl 2 synthesized by in vitro transcription . ^^^ RESULTS : fas mRNAs were expressed in 6 of 7 patients with RA . bcl 2 mRNAs were positive in 5 of 7 patients with RA . fasL mRNAs were not detectable in all the patients . bcl 2 mRNAs were always coexpressed with fas in RA synovial lining cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis related proteins , BCL 2 , BAX , FAS , FAS L and PCNA in liver biopsies of patients with chronic hepatitis B virus infection . ^^^ Recent evidence indicates that the elimination of HBV is achieved by FAS / FAS L induced apoptosis of infected hepatocytes . ^^^ The aim of this study was to test the hypothesis that HBV persistence in the hepatocytes of CHB patients is due to the delayed onset of apoptosis caused by altered FAS / FAS L interactions between lymphocytes and hepatocytes . ^^^ The expression of FAS , FAS L , BAX , BCL 2 , ICE and PCNA in the liver biopsies of 55 patients ( 14 HBsAg positive , 20 patients with alcoholic hepatopathy , 21 patients with other hepatopathies ) was tested by immunohistochemistry . ^^^ FAS L positive lymphocytes and hepatocytes were numerous in all patient groups . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the present investigations , the effects of irradiation with UVA and UVB on the Fas ( CD 95 ) / FasL system have been studied because apoptosis mediated by the interaction between Fas and FasL has been suggested recently to be associated with UVB induced immunosuppression in mouse skin . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Moreover , nearly half of the lytic response to IFNgamma treated SW 480 cells was inhibited by neutralizing anti Fas or anti Fasligand ( FasL ) mAb , revealing for the first time an important functional role for Fas / FasL interactions in carcinoma cell killing by human Ag specific CTL . mAb against HLA A 2 , ICAM 1 , the alpha T cell receptor ( TCR ) and Fas molecules inhibited lysis ; however , if these CTL were preactivated to express functional FasL and then used as effectors , only anti Fas mAb efficiently blocked lysis . ^^^ Overall , these data suggested that IFNgamma ( a ) facilitated both Ag dependent and Ag independent events as a prerequisite for efficient CTL / target interactions , FasL up regulation and triggering of Fas dependent , as well as Fas independent lysis ( perforin ) ; and ( b ) enhanced or restored a Fas sensitive phenotype in SW 480 cells , reflecting modulation of cell surface and intracellular elements of the Fas pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( APO 1 / CD95 ) is a transmembrane protein of the tumor necrosis factor ( TNF ) / nerve growth factor receptor superfamily that induces apoptosis in susceptible normal and neoplastic cells upon cross linking by its ligand ( FasL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Circulating fas levels correlated highly with serum nitrate concentration , but not with fas and fasL expression on PBMC of critically ill patients . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas , FasL , Bax , Bcl 2 , and pro and active caspase 3 were studied by immunohistochemistry . ^^^ Type 2 cells exhibited Fas , FasL , Bcl 2 , and procaspase 3 irrespective of treatment and time . ^^^ The results indicate that type 2 cells can enter the Fas / FasL / caspase 3 pathway regulated by Bax and Bcl 2 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activation of caspase 8 in response to Fas triggering by recruitment of caspase 8 to the Fas has also been found , however , MMC did not induce FasL and Fas expression , as evidenced by reverse transcriptase polymerase chain reaction and Western blotting . ^^^ Taken together , these findings indicate that MMC induced apoptosis in SNU 16 cells was mediated by caspase 8 , caspase 9 , and caspase 3 activation independently of FasL / Fas interactions . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It is a widely expressed membrane anchored protein that induces apoptosis by Fas / Fas ligand ( Fas L ) mediation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Induction of acute GVHD using perforin deficient donor T cells ( pfp > F 1 ) initially resulted in features of acute GVHD , e . g . , engraftment of both donor CD 4 ( + ) and CD 8 ( + ) T cells , upregulation of Fas and FasL , production of antihost CTL , and secretion of both Th 1 and Th 2 cytokines . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Further , elucidation of the mechanism of apoptosis induction in thymocytes with respect to the involvement of apoptosis related genes revealed that the death pathway followed an interleukin 1 beta converting enzyme dependent , Fas mediated apoptotic cascade , with a concomitant increase in the protein products of the bax , bad , p 53 , fas and fasL genes and cleavage of the 23 kD N terminal fragment of Bcl 2 that exhibited Bax like death effector properties . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In order to know about the effect of Bcl 2 on apoptosis induced by Fas , a typical member of `` Death factor ' ' family , the transfection experiments with expression vectors pcDNA 3 fl and pcDNA 3 bcl 2 were performed in BEL 7404 cells , a human hepatocellular carcinoma cell line which expresses endogenous Fas , but not FasL and Bcl 2 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Antagonist antibodies to Fas or FasL , or constitutive expression of crmA did not diminish the extent of resveratrol induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The TI data was compared with the immunohistochemically detected expression of proteins involved in apoptosis ( BCL 2 , FAS , FAS L , and caspase 1 ) , with grading , age , proliferative activity ( assessed by PCNA expression analysis ) and overall survival of patients . ^^^ We have demonstrated significantly higher values of both TI and expression of FAS L and caspase 1 in low grade tumors , which were characterized by a longer survival , lower average age and a lower expression of PCNA . ^^^ FAS L expression correlated significantly with the expression of the caspase 1 . ^^^ The expression of FAS L and caspase 1 in low grade astroglial tumors could indicate the increased readiness to apoptosis via the FAS / FAS L cascade . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Mitogen induced peripheral blood mononuclear cells were tested for interleukin ( IL ) 2 , IL 4 , IL 5 , IL 6 , IL 10 , IL 15 , Interferon gamma , Perforin , Granzyme B , and Fas L using semiquantitative reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas L expression in Huntington ' s disease and Parkinson ' s disease . ^^^ The Fas / Fas L signalling system plays a role in the control of cell death and the survival of lymphocytes , in the regulation of the immune system , and in the progression of autoimmune diseases . ^^^ Studies in the nervous system have shown Fas / Fas L activation in multiple sclerosis and in various paradigms leading to neuronal death . ^^^ Enhanced Fas and Fas L expression has also been documented in astrocytomas and glioma cell lines . ^^^ However , little is known about the possible implication of Fas / Fas L signals in primary human neurodegenerative diseases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These apoptosis inducers included Fas ( CD95 / APO 1 ) ligand ( FasL ) , short chain fatty acids , and chemotherapeutic drugs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas antigen expression was increased in thyroid cancer cells treated with GemMP [ 10 ] , whereas Fas L and Bcl 2 expression were not significantly affected . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Paraffin sections were analyzed histologically and cryosections were studied by the immunoperoxidase technique for the presence of HSV 1 , Fas and FasLigand ( FasL ) antigens . ^^^ RESULTS : In healthy corneas , Fas was detected in the epithelium , keratocytes and endothelium ; FasL was present in the epithelium and endothelium ; TUNEL positive cells were only found in the superficial epithelial cells . ^^^ The Fas FasL system appears to be involved in the induction of apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Bosentan , a mixed endothelin A and B ( ET ( A ) / ET ( B ) ) receptor antagonist , potentiated FasL ( APO 1 , CD 95 ) induced apoptosis in these cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas / Fas ligand ( FasL ) pathway has been shown to be an important cellular pathway mediating apoptosis . ^^^ In this study we investigated the expression of Fas and FasL and the rate of spontaneous apoptosis in 58 oral and oropharyngeal squamous cell carcinoma ( SCC ) by using immunohistochemical techniques . ^^^ There was no correlation between Fas or FasL expression and clinicopathological factors . ^^^ These results suggested that the Fas / FasL system is connected with the expression of various factors including cytokines in tumor cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It is coordinated by a number of molecules including the Fas Fas ligand ( FasL ) system and bcl 2 . ^^^ The purpose of this study was to characterize the expression of these molecules in human oocytes and cumulus cells from gonadotropin stimulated human ovaries and to determine whether the presence of soluble Fas ( sFas ) , soluble FasL , or interferon gamma in follicular fluid ( FF ) correlated with apoptosis in cumulus cells , oocyte maturation , and embryo quality . ^^^ Fas was expressed in both unfertilized oocytes and cumulus cells , whereas FasL expression was not usually detected in these cell types . ^^^ Our results indicate that soluble forms of the Fas FasL system are present in FF from gonadotropin stimulated human ovaries and suggest that this system may play a role in preventing oocyte atresia during folliculogenesis but is probably not important for apoptotic events in cumulus cells and oocytes after fertilization failure . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
FasL / Fas mediated lysis represents the major cytotoxic mechanism for CD 4 ( + ) effectors , with important consequences for immune cell homeostasis . ^^^ VIP / PACAP inhibit FasL expression in allogeneic effectors , and reduce Fas mediated cytotoxicity against specific allotargets and syngeneic bystanders . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This study was designed to compare the degree of lymphocyte apoptosis and Fas Fas ligand ( FasL ) expression in AIDS patients and long term non progressors ( LTNPs ) and correlate these parameters with apoptosis associated perturbations in lymphocyte function . ^^^ This correlated with a lower frequency of cells expressing Fas and FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , neurons are also protected by Fas Fc , which antagonizes the interactions between the death receptor Fas and its ligand FasL and by cell permeable peptides that inhibit caspases 8 and 3 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Hydrogen peroxide triggers the expression of Fas / FasL in astrocytoma cell lines and augments apoptosis . ^^^ In this study the up regulation of Fas / FasL by oxidative stress was shown . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The apoptosis was not blocked by yohimbine or antibodies to Fas and Fas L . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Staurosporine and H 7 induced cell death in SH SY5Y neuroblastoma cells is associated with caspase 2 and caspase 3 activation , but not with activation of the FAS / FAS L caspase 8 signaling pathway . ^^^ No modifications in the expression levels of Fas and Fas L were observed by Western blotting . ^^^ These findings indicate that the Fas / Fas L caspase 8 pathway of cell death signaling is not involved in staurosporine and H 7 induced apoptosis in SH SY5Y neuroblastoma cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and its ligand , FasL , are a receptor ligand pair identified as promoting cell death in several tissues . ^^^ Vascular smooth muscle cells ( VSMCs ) are resistant to FasL or anti Fas antibody ( Ab ) signal , and a number of in vitro studies show that VSMC death can only be induced by anti Fas Ab or FasL in the presence of protein inhibitor or additional inflammatory mediators . ^^^ It remains to be clarified whether known , constitutively expressed cytoprotective molecules are reduced by protein inhibitor , thereby accounting for sensitization to cell death by Fas / FasL signaling . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Noninfectious CXCR 4 tropic HIV 1 virions , but not microvesicles , partially activated freshly isolated CD 4 ( + ) and CD 8 ( + ) peripheral blood mononuclear cell T lymphocytes to express FasL and Fas , but not CD 69 or CD 25 ( interleukin 2 receptor alpha ) and eventually die via apoptosis starting 4 to 6 days postexposure . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tumor escape mechanism involving Fas and Fas L molecules in human colorectal tumors ] . ^^^ OBJECTIVES : The interaction between Fas and its ligand ( Fas L ) leads to Fas positive cell apoptosis . ^^^ The presence of Fas L mRNA was analyzed by RT PCR . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NK cells induced apoptosis of mycobacterium infected MN , but neither killing of intracellular M . tuberculosis by NK cells nor NK cell induced apoptosis of infected MN was inhibited by blocking the interaction of FasL and Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Fas ligand ( FasL ) system is a mechanism responsible for activation induced cell death ( AICD ) , which maintains homeostasis within the immune system . ^^^ Thus , Fas / FasL expression on activated colonic T cells of UC patients , as well as the susceptibility of such T cells to AICD was investigated in order to determine the role of activated colonic T cells in the long lasting inflammation in UC . ^^^ METHODS : Fas , FasL , and CD45RO expression on peripheral blood and colonic T cells of UC patients were assayed by flow cytometry . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Low doses of UVB , 5 20 mJ / cm2 , increase the levels of apoptosis as shown by increased levels of fragmented DNA , Fas , PARP , and FasL protein , and the number of apoptotic cells as assessed by FACS analysis . ^^^ At higher doses of UVB ( 20 and 30 mJ / cm2 ) the number of apoptotic cells becomes reduced , as does the amount of Fas , PARP , and FasL protein . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunohistochemistry and the terminal deoxynucleotidyl transferase mediated dUTP digoxigenin nick end labeling ( TUNEL ) method were applied to study the Fas and FasL expression and the incidence of apoptosis in salivary glands ( SG ) from patients with primary and secondary SS , AF , and controls . ^^^ Despite abundant expression of Fas and FasL in SS SG , apoptotic cells were not exceeding 1 % in the foci of infiltrating mononuclear cells ( IMC ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We investigated the presence and functional status of surface expression of the Fas receptor ( FasR ) and its ligand ( FasL ) in tumor and tumor infiltrating lymphocytes ( TIL ) in gastric carcinoma ( n = 36 ) from the primary locus , metastatic gastric carcinoma ( n = 30 ) from malignant ascites , and benign gastric mucosa ( n = 30 ) for the control . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
FAS and FASL were not differentially expressed , but FAST kinase was over expressed in AN and AA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
At a higher concentration , gp 120 not only promoted HMC apoptosis but also enhanced expression of Fas and FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of FAS and FASL genes in brain and effect of flunarizine on these expressions in rats after global ischemia reperfusion ] . ^^^ AIM : To explore the expression of Fas and FasL genes after ischemia reperfusion in rats and the effect of flunarizine . ^^^ The biopsy tissues from brain were immunohistochemically assayed with Fas and FasL genes polyclonal antibody . ^^^ The expression of Fas and FasL gene was quite obvious in the cortex and hippocampus CA 1 , the more sensitive areas to ischemic injury . ^^^ Flunarizine i . p . 10 mg . kg 1 and 20 mg . kg 1 obviously inhibited the expression of Fas and FasL in dose dependent manner . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , the expression of Fas and FasL protein in Western blotting was not affected by butyric acid treatment . ^^^ These results suggest that the Fas FasL interaction is not involved in butyric acid induced apoptosis and that caspase 8 and 9 dependent apoptosis plays an important role in butyric acid induced apoptosis , as well as Fas induced apoptosis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , upon triggering of cytokine treated cells with FasL , we observed upregulation of the cleavage product of FLIP ( p 43 FLIP ) previously shown to associate with the DISC and to block caspase 8 recruitment , thereby inhibiting Fas mediated death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression pattern of Fas , FasL and FLICE inhibitory protein was comparable in all three cell lines . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
HLEC 16 and HLEC16T expressed Fas protein ( Fas ) but not Fas ligand ( FasL ) mRNA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We have studied the impact of fas / fasL signaling , an important T cell apoptotic pathway , on the effects of costimulation blockade . ^^^ Wild type , lpr ( fas deficient ) , and gld ( fasL deficient ) , mice were used as donors and recipients in the murine skin graft model . ^^^ Fas expression is not critical for costimulation blockade resistant rejection , suggesting that fasL may be interacting with other receptors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The involvement of death receptors was analyzed using neutralizing monoclonal antibodies against Fas ( SM1 / 23 ) , FasL ( NOK 2 ) and TNF R 1 ( MAB 225 ) , and a polyclonal rabbit anti human TNF related apoptosis inducing ligand ( TRAIL ) antiserum . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Our initial studies revealed that tsTNC 1 cells express both FasL and TNFalpha apoptosis of triple positive cells was shown to be reduced approximately 50 % in co cultures of tsTNC 1 cells and thymocytes in the presence of either anti TNFalpha or Fas Fc . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Next , we correlated survivin expression with Fas , FasL and the amount of apoptosis over time in culture . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Additionally , since B cells may up regulate CD95 / Fas expression upon binding of CD 20 directed antibodies , B cells will become even more sensitive for T cell mediated killing via CD95L / Fas L , and therefore supports the intention to use T cell retargeting bi specific antibodies recognizing CD 20 on B cell malignancies as a treatment modality for these diseases . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Alteration of Fas / FasL expression of oral squamous cell carcinoma cell line Tca 83 induced by retinoic acid . ^^^ Cell apoptosis as well as Fas / FasL expression were analyzed by TUNEL , RT PCR , and immunohistochemistry approaches . ^^^ Both Fas and FasL could be detected in the treated and untreated cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In 5 of 20 ( 25 % ) , there was profound resistance to exogenous FasL mediated lysis , Fas mAb , and anti CD 3 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas FasL in Hashimoto ' s thyroiditis . ^^^ Later , autonomous interaction between thyrocyte Fas and FasL has been proposed as a major mechanism of thyrocyte depletion in Hashimoto ' s thyroiditis . ^^^ Here , we analyze the possible role of Fas and FasL in the pathogenesis of Hashimoto ' s thyroiditis . ^^^ We suggest that the Fas FasL system dictates the outcome of the autoimmune response by acting on both immune and target cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis was determined using the terminal TdT mediated dUTP biotin nick end labeling ( TUNEL ) technique ; electron microscopic analysis ; and expression of Caspase 3 , Fas , FasL , Bcl 2 , and p 53 by immunohistochemistry . ^^^ Positive staining for active caspase 3 , Fas , FasL , and p 53 was only observed in the inflammatory infiltrate from periodontitis biopsies , whereas Bcl 2 cells were present in both periodontitis patients and healthy controls . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This deficiency can be caused by a mutation of the APT 1 gene ( ALPS type Ia ) , of the FasL gene ( ALPS type Ib ) , or of the Caspase 10 gene ( ALPS type 2 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Upregulation of two death pathways of perforin / granzyme and FasL / Fas in septic acute respiratory distress syndrome . ^^^ Quantitative polymerase chain reaction ( PCR ) analysis revealed that the messenger ribonucleic acids ( mRNAs ) for several apoptosis molecules , such as perforin , granzyme A , granzyme B , FasL , and Fas were highly upregulated in the acute phase of ARDS following sepsis . ^^^ These results thus suggested that the dual apoptosis pathway , perforin / granzyme and FasL / Fas system , is likely to be another participant for the pathogenesis of acute lung injury . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Binding of FasL with functionally active CD 95 receptors on chief and parietal cells may be relevant for induction of apoptosis in inflamed gastric mucosa . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas , a cell surface protein , can be triggered by an appropriate death promoting ligand ( FasL ) to activate downstream caspases pivotal in initiation of programmed cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tributyrin is found to be a potent inducer of ICAM 1 , LFA 3 and Fas on target cells corresponding to an increase of the FasL expression by IL 2 / IL 12 on the effector cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas / FasL system is an important apoptotic regulatory pathway in a wide variety of cells . ^^^ Fas is a widely expressed cell surface protein that transduces an apoptotic signal after interaction with its natural ligand FasL . ^^^ In contrast to the extensive tissue distribution of Fas , constitutive expression of FasL is relatively limited . ^^^ We examined Fas and FasL expression by neutrophils in healthy subjects , patients with CRF , and patients on hemodialysis ( HD ) and peritoneal dialysis ( PD ) . ^^^ Finally , we found that uremic serum increased the expression of neutrophil associated Fas and FasL proteins , when compared with normal serum . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Brain tumors and melanomas have been shown to produce their autocrine FasL , and are even capable of switching CD 95 related signal transduction from the PCD pathway to a proliferative pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / FasL mediated apoptosis of thyrocytes in Graves ' disease . ^^^ We examined in the present study the possible involvement of Fas and its ligand ( FasL ) in the process of Graves ' disease . ^^^ In vitro treatment of thyrocytes by IL 1beta a cytokine found to be expressed in Graves ' thyroid glands , increased Fas but reduced FasL expression . ^^^ This cytotoxic activity involved the Fas / FasL pathway . ^^^ Our results suggest that the apoptotic cell death of both thyrocytes and infiltrating MNCs found in Graves ' thyroid glands is regulated by IL 1beta through Fas / FasL interactions . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here we have studied the Fas / FasL system in relation to clinical progression in B CLL . ^^^ Serum levels of soluble Fas ( sFas ) and FasL ( sFasL ) were determined by ELISA in 43 progressive and 40 non progressive B CLL patients and in 21 control individuals . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Whether this mechanism is Fas / FasL , TRAIL / TRAILR dependent can not be confirmed as specific blocking reagents were not able to inhibit cell induced death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas mediated and chemotherapy induced apoptosis can converge at the level of the receptor , FasL , DISC formation , activation of the initiator caspase 8 , at the level of the mitochondria , or at the level of downstream effector caspase activation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Experiments with mice deficient in FasL and Fas , with transfer of FasL gene and with anti CD 8 antibody , suggest that the veto activity associated with cytotoxic T lymphocytes ( CTLs ) requires simultaneous expression of FasL and CD8 . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
IL 18 , a product of choriodecidual cells , increases during premature rupture of membranes but fails to turn on the Fas FasL mediated apoptosis pathway . ^^^ The ability of IL 18 to induce the Fas Fas ligand ( FasL ) / caspase mediated apoptotic pathway is also studied . ^^^ Multiplex PCR was used to study the expression pattern of proapoptotic genes such as Fas , FasL , caspase 8 , and Fas associated death domain ( FADD ) . ^^^ IL 18 induced Fas expression in amniochorion ; however , it failed to turn on other genes in the Fas FasL apoptosis pathway including FasL and caspase 8 . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We analysed both the expression of Fas using flow cytometry techniques and the expression of FasL mRNA using RT PCR in CVI T cells . ^^^ We could not find any significant differences between CVI and normal subjects with regard to Fas expression , although there was a subgroup of CVI patients with very high Fas expression which was accompanied by an up regulation of FasL mRNA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In autoimmune type 1 diabetes , Fas to Fas ligand ( FasL ) interaction may represent one of the essential pro apoptotic pathways leading to a loss of pancreatic beta cells . ^^^ Human islets normally express FasL but not the Fas receptor . ^^^ The effect of glucose was blocked by an antagonistic anti Fas antibody , indicating that glucose induced apoptosis is due to interaction between the constitutively expressed FasL and the upregulated Fas . ^^^ Upregulation of the Fas receptor by elevated glucose levels may contribute to beta cell destruction by the constitutively expressed FasL independent of an autoimmune reaction , thus providing a link between type 1 and type 2 diabetes . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : C57BL / 6 ( wild type mice ) , B6MRL / lpr , and B6MRL / gld ( defective Fas or FasL expression , respectively ) mice were infected intraperitoneally with 20 to 30 tissue cysts of the ME 49 strain of T . gondii . ^^^ Analysis included immunostaining for Fas , FasL , Bcl 2 , and Bax ; in situ apoptosis detection ( TUNEL assay ) ; RT PCR amplification for IFN gamma ; and measurement of ocular nitrite levels . ^^^ Untreated nave lpr and gld mice showed no expression of Fas and FasL , respectively . ^^^ CONCLUSIONS : No significant difference in the degree of ocular inflammation and apoptosis was detected between the wild type and Fas or FasL mutant mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas in suprabasal to superficial cells and expression of Fas L in basal and parabasal cells were detected in lining epithelium of OKCs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : Fas / Fas ligand ( FasL ) system is one of the major pathways triggering apoptosis that has been shown to play an important role in development and pathogenesis of various diseases including liver and gastrointestinal diseases . ^^^ However , the extent to which Fas / FasL contributes to organ injury during sepsis is unclear . ^^^ CONCLUSIONS : These results not only indicate that there is a role for Fas / FasL mediated processes in the induction of organ injury but suggest that inhibition of Fas / FasL pathway may represent a novel therapeutic modality for maintaining organ perfusion and preventing liver injury during sepsis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The characteristic destruction of epithelial cells of Sjgren ' s syndrome patients is probably due to activation of several apoptotic pathways since epithelial cells express different apoptosis related molecules such as Fas , FasL , Bax , while mononuclear cells express Perforin and Granzymes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
When p 53 is activated it can either induces the expression of p 21 ( Waf 1 , Cip 1 ) , which participates in the cellular arrest between G 1 S transition , or the expression of bax , PIGs , IGF BP 3 , Fas , FasL and DR 5 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas / Fas ligand ( FasL ) system has been implicated in alveolar epithelial cell apoptosis during pulmonary fibrosis and acute respiratory distress syndrome . ^^^ The goal of this study was to determine the role of the Fas / FasL system in host defenses against Escherichia coli , Staphylococcus aureus , and Streptococcus pneumoniae . ^^^ We conclude that the Fas / FasL system contributes to the development of permeability changes and tissue injury during gram negative bacterial pneumonia . ^^^ The Fas / FasL system did not have a major role in the clearance of aerosolized bacteria from the lungs at the bacterial doses tested . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We also show that EBV specific CD4+ T cells mediate bystander lysis of susceptible targets through both the Fas / Fas ligand ( FasL ) and the TRAIL pathways , but find that the dominant mechanism of lysis following cognate , HLA class 2 restricted recognition of LCL is the perforin / granzyme pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Independent contributions of GR 1+ leukocytes and Fas / FasL interactions to induce apoptosis following interleukin 12 gene therapy in a metastatic model of prostate cancer . ^^^ In vitro studies noted the ability of IFN gamma to up regulate tumor cell expression of Fas and FasL to mediate apoptosis , whereas in vivo blockage of Fas / FasL interactions with soluble Fas resulted in a modest reduction in primary tumor growth suppression but complete abrogation within metastatic lesions . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( CD95 / APO 1 ) ligand ( FasL ) mediated cytotoxicity has been implicated in tissue destruction in a variety of diseases , including acute graft vs host disease ( GVHD ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Overexpression of FLIP by transfection in a Fas and TRAIL sensitive human melanoma cell line rendered this cell line more resistant to death mediated by both TRAIL and FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Study on Fas / Fas L expression in liver tissue and hepatocyte apoptosis in patients with hepatitis gravis . ^^^ To explore the expression of Fas / Fas L in liver tissue of hepatitis gravis patients and its implication in hepatocyte apoptosis , Fas / Fas L expression and cell apoptosis was detected by the means of inmmunohistochemistry and terminal deoxynucleotidyl transferase mediated dUTP nick end labeling ( TUNEL ) . ^^^ It was found that in the 20 patients with clinical hepatitis gravis , Fas in hepatocytes showed strong expression and Fas L also showed intensive expression in infiltrating lymphocytes and scattering hepatocytes . ^^^ It was suggested that the overexpression of Fas / Fas L could cause the death of hepatocytes and thus the occurrence of hepatitis gravis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of Fas / FasL in peripheral blood lymphocytes and the level of IL 2 in serum of patients with condyloma acuminata . ^^^ In order to investigate the role of the expression of the Fas / FasL in peripheral blood lymphocytes ( PBLC ) and the level of IL 2 in serum of patients with condyloma acuminata ( CA ) in the immune pathogenesis of CA , flow cytometry , indirect immunofluorescence labeling and ELISA were performed to detect the expression of the apoptotic regulatory proteins Fas / FasL in PBLC and the level of IL 2 in serum of 60 patients with different course of CA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the light of the recent findings about the Fas Fas ligand ( FasL ) system in regulating lymphocyte homeostasis , the aim of the present study was to investigate peripheral lymphocyte Fas mediated apoptosis in CD to establish whether the homeostatic role of apoptosis in peripheral T cell selection is maintained . ^^^ Moreover , because a soluble form of Fas has been described to be functionally implicated in the Fas signalling system , suggesting a relationship between some disorders and soluble Fas function , we measured levels of soluble Fas in sera of coeliac patients and analysed the relationship between these levels and the proportions of apoptotic and Fas ( + ) PBL to further explore the function of the Fas FasL pathway in this condition . ^^^ We demonstrated an increased apoptosis and higher levels of Fas and FasL expression in PBL isolated from untreated coeliac patients when compared to treated coeliac patients and controls . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We recently showed that FC loading of macrophages causes apoptosis , approximately 50 % of which is mediated by activation of cell surface FasL and triggering of the Fas pathway ( Yao , P . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The CD 95 ligand ( FasL ) transmembrane protein is found on activated T cells and cells outside the immune system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Acinar cell proliferation was reduced , while expression of Fas , FasL and bcl 2 were increased . ^^^ Acinar cell proliferation was reduced , while expression , of Fas , FasL and bcl 2 were increased . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Par 4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression . ^^^ Par 4 induced apoptosis of selective prostate cancer cells PC 3 , DU 145 , and TSU Pr and caused tumor regression by inhibition of NF kappaB activity and cell membrane trafficking of Fas and FasL that leads to the activation of the Fas Fas associated death domain caspase 8 pro death pathway . ^^^ On the other hand , prostate cancer cells LNCaP or normal prostatic epithelial cells that were resistant to apoptosis by Par 4 did not show Fas or FasL trafficking . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Sjogren ' s syndrome ( SS ) is an exocrinopathy characterized by T cell infiltrates , salivary gland epithelial cell ( SGEC ) apoptosis and high Fas and FasL expression . ^^^ Possibly attesting to their intrinsic activation , cell lines derived from SS patients displayed significantly higher constitutive Fas and FasL than controls . ^^^ Surface co expression of Fas and FasL was not associated with spontaneous fratricide apoptosis . ^^^ IFN gamma and TNF alpha were able to upregulate surface Fas and FasL , whereas IL 1beta downregulated surface FasL . ^^^ IFN gamma ( but not several other cytokines ) reduced the survival of SGEC in a dose and time dependent manner and induced Fas / FasL mediated apoptosis , directly and via anoikia . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Despite surface expression of Fas on tumor cells and Fas L induction on TC 5 and TC 7 cell membrane after coculture with autologous tumor cells , the CD4+ CTL clones did not use this cytotoxic mechanism to lyse their specific target . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In Hashimoto ' s thyroiditis , both FasL and its receptor , Fas , are strongly upregulated and their interaction leads to the suicidal / fratricidal death of thyrocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
FasL , Fas , FADD , RIP , caspase 8 , caspase 3 , Bid , FLIP ( S+L ) , FLASH and FAP 1 , proteins known to act within the Fas apoptosis cascade , showed no changes in their expression levels in cells treated with butyrate compared with untreated cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RESULTS : The mRNA expression positive rate of IL 10 , CD40L , Fas , Perforin , IL 2 , IFN gamma , FasL , bcl xL , Granzyme B ( GB ) , TGF beta 1 and IL 4 was 91 . 8 % , 70 . 5 % , 88 . 5 % , 96 . 7 % , 41 % , 54 . 1 % , 60 . 7 % , 67 . 2 % , 67 . 2 % , 54 . 1 % and 32 . 8 % respectively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Our aim was to evaluate whether increased enterocyte apoptosis was responsible for mucosal flattening in celiac disease ( CD ) , and , since the mechanisms responsible for tissue injury in this condition are unknown , we studied the possibility that the Fas Fas ligand ( FasL ) system may be involved . ^^^ Endoscopic duodenal biopsy specimens from 12 patients with untreated and 12 with treated CD and 12 control subjects were evaluated for enterocyte apoptosis by the terminal deoxynucleotidyl transferase mediated digoxigenin deoxyuridine triphosphate nick end labeling assay and for Fas and FasL expression by immunohistochemistry . ^^^ Most celiac enterocytes express Fas , and LPMCs express FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , although FasL and Fas were detected on DC and HPV+ cell lines , respectively , functional analysis revealed that this pathway is not responsible for the apoptosis induced by the DC . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Since the Fas / FasL system is one of the main pathways in T cell apoptosis , we tested the hypothesis that estrogen induced thymic atrophy is mediated by the Fas / FasL system . ^^^ Fas and FasL mRNA and protein expression was evaluated using RT PCR and Western blot analysis respectively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Increasing attention has been directed to the possible role of Fas and its cognate ligand ( Fas L ) , a subject of wide interest . ^^^ Documentation of in vitro data supports the role of Fas and Fas L in erythropoiesis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ligation of the cell surface Fas molecule by its ligand ( Fas L ) or agonistic anti Fas monoclonal antibodies results in the cleavage and activation of the cysteine protease procaspase 8 followed by the activation of procaspase 3 and by apoptosis . ^^^ In some leukemia cell lines , cytotoxic drugs induce expression of Fas L , which may contribute to cell killing through the ligation of Fas . ^^^ The involvement of Fas , Fas L , and caspase 8 was studied in the killing of B cell chronic lymphocytic leukemia ( B CLL ) cells by chlorambucil , fludarabine , or gamma radiation . ^^^ None of the cytotoxic stimuli studied here induced Fas L expression . ^^^ These data suggest that the Fas / Fas L signaling system does not play a major role in the induction of apoptosis in B CLL cells treated with cytotoxic drugs or radiation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To study the mechanism of thyrocyte loss in various forms of thyroiditis , we evaluated in situ expression patterns of CD 40 , Fas , and Fas L on thyrocytes and infiltrating inflammatory cells by immunohistochemical staining of thyroid samples obtained from 49 patients ( Graves ' disease , n=10 : Hashimoto ' s thyroiditis , n=14 ; nonspecific lymphocytic thyroiditis , n=11 ; subacute granulomatous thyroiditis , n=11 ; normal , n=3 ) . ^^^ CD 40 was not expressed on thyrocytes of normal controls while they showed a diffuse expression of Fas and a scattered focal expression of Fas L . ^^^ The plump thyrocytes proximal to the inflammatory infiltrates showed more intense expressions of these three molecules in various forms of thyroiditis and a close correlation was found between CD 40 and Fas L expression on thyrocytes . ^^^ Unlike Fas , which was expressed on infiltrating lymphocytes in all groups , Fas L was not expressed on infiltrating lymphocytes , except those in subacute granulomatous thyroiditis . ^^^ These results show the acquisition of CD 40 , Fas and Fas L molecules on thyrocytes proximal to inflammatory cell aggregates and the negligible expression of granzyme B and Fas L on the infiltrating lymphocytes , and suggest that Fas and Fas L mediated apoptosis of thyrocytes ( fratricide ) may be more important than T cell mediated cytotoxicity in various forms of thyroiditis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of fas / fas ligand ( fasL ) and its involvement in infiltrating lymphocytes in hepatocellular carcinoma ( HCC ) . ^^^ BACKGROUND : This study was conducted to examine the expression of Fas / Fas ligand ( FasL ) , to elucidate its relationship with tumor infiltrating lymphocytes ( TILs ) , and to detect possible gene mutation of Fas / FasL in patients with hepatitis C virus ( HCV ) related hepatocellular carcinoma ( HCC ) . ^^^ Fas / FasL mRNA expressing cells and apoptotic cells were detected by in situ hybridization and DNA nick end labeling ( TUNEL ) , respectively . ^^^ We also performed polymerase chain reaction ( PCR ) amplifying and direct sequencing for the Fas / FasL gene . ^^^ RESULTS : Fas / FasL and its mRNA were localized on the membrane or in the cytoplasm in some HCC cells , as well as hepatocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tumor cells or tumor derived macrophages do not express FasL , and blocking Abs to either Fas or FasL have no effect on macrophage mediated T cell killing . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
It was shown that Fas and FasL mRNA and protein were localized in both the chorionic villi and glandular epithelium from day 15 to day 30 of pregnancy . ^^^ Fas and FasL protein were also expressed in the epithelial plaque on day 15 of pregnancy . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis was assessed by the in situ end labeling of double stranded DNA breaks , and by immunohistochemical characterization of cellular markers associated with apoptosis ( Fas , FasL , Bcl 2 , and Bax ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We also show that granuloma lymphocytes are more susceptible to Fas FasL mediated apoptosis than spleen lymphocytes and this apoptosis may be related to antigen concentration . ^^^ Conversely , eosinophils from the granuloma and spleens of S . mansoni infected mice are resistant to apoptosis in vivo and are protected in vitro from Fas FasL mediated apoptosis by the absence of FasL expression in the presence of Fas expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis in T cells is triggered by the interaction of the membrane receptor Fas with its normal ligand Fas L , or an activating antibody . ^^^ Now lung carcinoma cells have been shown to express Fas L , enabling them to destroy cytolytic T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Importantly , 16 10A1 could retard the growth of lymphomas and favored the up regulation of pro apoptotic molecules caspase 3 , caspase 8 , Fas , FasL , Bak , and Bax and down regulation of anti apoptotic molecule Bcl 10 ( L ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immature dendritic cells kill ovarian carcinoma cells by a FAS / FASL pathway , enabling them to sensitize tumor specific CTLs . ^^^ This cytotoxicity was independent of Ca ( 2+ ) and could be inhibited by anti Fas IgG 1 monoclonal antibody , indicating the involvement of the Fas / Fas ligand ( FasL ) pathway in the cytotoxic mechanism . ^^^ Further supporting this conclusion , the ascitic monocyte derived DCs expressed high levels of FasL mRNA and intracellular FasL and significant levels of Fas were also revealed on the surface of ovarian tumor cells . ^^^ Collectively , these results demonstrate that immature DCs can kill autologous ovarian carcinoma cells via the Ca ( 2+ ) independent Fas / FasL pathway and that this may have important consequences for their ability to stimulate tumor specific CTLs . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Mifepristone regulates expression of apoptosis related genes Fas and FasL in mouse endometrium . ^^^ The expression of apoptosis related genes , Fas and FasL , in mouse endometrium was also decreased after mifepriston treatment . ^^^ CONCLUSION : The expression of apoptosis related genes Fas and FasL is regulated by mifepriston and the inhibitory effect of mifepriston on the embryo implantation may be mediated by action on the Fas / FasL system . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : The expression of bcl 2 , bax , Fas and FasL were detected with immunohistochemistry method in 45 cases of NSCLC . ^^^ RESULTS : 23 ( 51 % ) cases of NSCLC were bcl 2 positive , 38 ( 84 % ) were bax positive ( P < 0 . 01 ) , and there was no significant correlation between the expression of bcl 2 and bax protein , but a positive relationship was found between the expression of Fas and FasL ( P < 0 . 01 ) . ^^^ CONCLUSIONS : Both bcl 2 , bax , Fas and FasL may involve in the regulation of apoptosis and may play an important role in the occurrence and progression of NSCLC . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The role of apoptosis and Fas / FasL in lung tissue in patients with acute respiratory distress syndrome ] . ^^^ By using TUNEL , histopathology and immunocytochemistry techniques , apoptosis and Fas , FasL protein expression were studied in patients with ARDS in acute stage and in control subjects . ^^^ Fas , FasL protein expression were up regulated in lung tissues of patients with ARDS . ^^^ There was a significant correlation between expression of Fas , FasL and ratio of apoptosis . ^^^ CONCLUSIONS : During the acute stage of ARDS , increase of apoptosis ratio in alveolar epithelial cells and pulmonary vascular endothelial cells , and activation of Fas / FasL system may contribute to the pathogenesis of this syndrome . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cell proliferation , morphology and death pattern as well as Fas / FasL expressions were analyzed by multiple approaches . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Effects of dexamethasone on apoptosis and expression of Fas / FasL system in lung tissues of ALI rats ] . ^^^ METHODS : By using TUNEL , in situ hybridization , SqRT PCR and immunocytochemistry techniques , apoptosis and Fas , FasL expression were studied during early phase of ALI in rats . ^^^ The expression of Fas , FasL mRNA and protein was up regulated in lung tissues of rats with ALI . ^^^ The administration of dexamethasone suppressed apoptosis as well as expression of Fas , FasL mRNA and protein , inhibited TNF alpha production and abated lung injury . ^^^ CONCLUSIONS : The excessive apoptosis and Fas / FasL system may play a role in the pathogenesis of LPS induced ALI in rats . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Their cell cycle profiles , cytokine , Fas and FasL mRNA messages , and surface expression of Fas and FasL were determined . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cross linking of Fas by its ligand , FasL , or agonistic anti Fas antibodies , induces apoptosis of cells expressing Fas on the membrane by triggering a cascade of caspases . ^^^ Because several different cytotoxic drugs are able to induce Fas membrane expression , combination therapy of anticancer drugs with anti Fas antibodies or FasL is conceivable as an anticancer strategy . ^^^ The efficiency of the induction of Fas mediated apoptosis by anti Fas antibodies , FasL expressing cells or recombinant FasL ( rFasL ) in tumours has been demonstrated in vivo in solid tumours implanted in mice . ^^^ Unfortunately , systemic treatment with anti Fas antibodies or rFasL causes severe damage to the liver , so most preclinical studies are now focusing on circumvention of this problem by local administration of FasL , or on the use of inducible FasL expressing vectors as gene therapy . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Experimental results demonstrate that both CM IL1beta and CM IL 8 have the ability to delay caspase activation , but have no effect on the expression of their upstream activator , Fas , or its ligand , FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas / Fas ligand ( FasL ) system plays an important role in cellular apoptosis and is involved in cancer cell death induced by the immune system and anticancer drugs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression and distribution of Fas , FasL , Bcl 2 and Bax proteins in the specimens were investigated with immunohistochemical methods . ^^^ Positive rates of Fas , FasL , Bcl 2 and Bax in thyroid cells of NTG ( 35 % approximately 47 % ) were significantly lower than those in thyroid cells of HT ( 88 % approximately 94 % , P < 0 . 01 ) . ^^^ The intensity of positive immunostaining for Fas , FasL , Bcl 2 and Bax in thyroid cells of HT was significantly higher than that of the controls ( P < 0 . 01 ) . ^^^ Apoptosis and strongly positive immunostained thyroid cells with HT for Fas , FasL and Bax were mainly distributed in follicles adjacent to lymphocytic infiltrates , whereas strongly positive stained thyroid cells for Bcl 2 were mainly located in the area remote from the infiltrating lymphocytes . ^^^ Staining of infiltrating lymphocytes for Fas , FasL , Bcl 2 and Bax was weak . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( APO 1 / CD95 ) and its ligand ( FasL / CD95L ) are cell surface proteins whose interaction activates apoptosis of Fas expressing targets . ^^^ In T lymphocytes , the Fas / FasL system regulates activation induced cell death , a fundamental mechanism for negative selection of immature T cells in the thymus and for maintenance of peripheral tolerance . ^^^ Aberrant expression of Fas and FasL has also been implicated in diseases in which the lymphocyte homeostasis is compromised , and several studies have described the pathogenic functions of Fas and FasL in vivo , particularly in the induction / regulation of organ specific autoimmune diseases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Despite the importance of PA in lung cancer treatment , the function of Fas , DR 4 and DR 5 in PA induced apoptosis , as well as the effect of their respective ligands FasL and TRAIL alone or in combination with PA , remains poorly understood . ^^^ All the lung cancer cells express Fas , FasL , DR 4 and DR 5 ; however PA did not significantly modify their levels . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Conversely , augmented antigen dependent Rap 1 activation by the expression of wild type Rap 1 enhances these responses but culminates in apoptosis by Fas and FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To block the Fas Fas ligand interaction , an anti Fas ligand antibody ( FasL ) was injected with ADR 7 , 8 , and 9 wk after first administration of ADR . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Disturbed expression of Fas / FasL on CD 4 ( + ) and CD 8 ( + ) T cells in Behcet ' s disease , Vogt Koyanagi Harada syndrome , and idiopathic anterior uveitis . ^^^ AIMS : To evaluate the expression of Fas / FasL antigen on peripheral blood T lymphocytes in patients with Behcet ' s disease , Vogt Koyanagi Harada ( VKH ) syndrome , and idiopathic anterior uveitis . ^^^ METHODS : The expression of Fas and FasL on peripheral blood T lymphocytes was determined using flow cytometry in 26 patients with Behcet ' s disease ( BD ) , 17 patients with VKH syndrome , 25 patients with idiopathic anterior uveitis , and 43 healthy individuals ( controls ) . ^^^ CONCLUSION : A disturbed expression of Fas and FasL on T cells is present in patients with Behcet ' s disease , VKH syndrome , and idiopathic anterior uveitis , which may be involved in the perpetuation and recurrence of uveitis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The present study examined the role of the Fas / FasL pathway in this process . ^^^ RESULTS : An increase in Fas and FasL expression was observed in glomerular and tubular compartments of kidneys of hypertensive S rats , whereas dietary salt did not change expression of either of these molecules in normotensive Sprague Dawley rats . ^^^ CONCLUSIONS : Augmented expression of apoptotic signaling by the Fas / FasL pathway occurred during development of end stage renal failure in this model of hypertensive nephrosclerosis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expressions of Fas and Fas L in human breast invasive ductal carcinomas and their surrounding tissues ] . ^^^ OBJECTIVE : To study the relationship of the expression of Fas and Fas L with the pathogenesis and differentiation of breast invasive ductal carcinomas . ^^^ METHODS : Both carcinoma tissues and their surrounding tissues from 50 patients with breast invasive ductal carcinomas were studied for the expression of Fas and Fas L by immunohistochemical staining . ^^^ RESULTS : The expression level of Fas in breast ductal carcinoma was significantly lower than that of tissues surrounding carcinomas , and the expression level of Fas L in breast ductal carcinoma was significantly higher than that of tissues surrounding carcinomas . ^^^ There was no significant difference in the expression of Fas and Fas L in carcinomas with different differentiation grades . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The polymorphonuclear leukocyte ( PMN ) apoptotic receptors , Fas and FasL , were studied together with the activity of caspase 3 in postoperative neutrophils . ^^^ Western blot analysis showed a normal expression of the apoptotic receptors Fas and FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The aim of this study was to investigate the involvement of the Fas / Fas ligand ( Fas / Fas L ) system in the H . pylori infected gastric corpus . ^^^ The expression of Fas and Fas L was examined by immunohistochemistry and RT PCR . ^^^ We studied the in vitro expression of Fas L in peripheral T cells after stimulation with H . pylori antigen and interferon gamma ( IFN gamma ) . ^^^ Fas expression was abundantly increased on fundic gland epithelium , and Fas L was detected on lamina propria mononuclear cells in H . pylori infected mucosa . ^^^ H . pylori antigen and IFN gamma induced Fas L mRNA expression in both CD4+ and CD8+ T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
They had been investigated by the in situ end labeling and immunohistochemical staining to detect the apoptotic cells and the expression of Fas , FasL , bcl 2 and Bax . ^^^ RESULTS : The number of epithelial apoptotic cells in lacrimal glands of patients with SS was significantly higher than that in normal glands , and SS epithelial cells showed increased expression of Fas , FasL and Bax . ^^^ There was significant positive correlation between the number of the apoptotic cells and that of the cells expressing Fas , FasL and Bax , respectively , and there was significant negative correlation between the number of the apoptotic cells and that of the cells expressing bcl 2 . ^^^ In SS lacrimal glands , the expression of Fas , FasL and Bax may promote apoptosis , and the expression of bcl 2 may inhibit apoptosis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CONCLUSION : Hilar cholangiocarcinomas may elude immunological surveillance by inducing , via Fas / FasL system , the apoptosis of activated lymphocytes . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
FasL and TRAIL are apoptotic ligands of the TNF like cytokines family , acting via activation of the transmembrane death domain containing receptors Fas for FasL , and DR 4 or DR 5 for TRAIL . ^^^ Surprisingly , despite lacking the death domain region of functional Fas , Fas GPI was able to significantly increase Fas mediated cell death triggered by membrane bound or soluble FasL , whereas engagement of Fas GPI alone did not trigger apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The predictive value of bcl 2 , bax , bcl xL , bag 1 , fas , and fasL for chemotherapy response in advanced breast cancer . ^^^ PURPOSE : The purpose was to evaluate the utility of some bcl 2 family proteins fas and fasL as predictive indicators for chemotherapy response in advanced breast cancer . ^^^ In 126 patients , histological blocks of primary tumors were available for immunohistochemical analysis of bax , bcl 2 , bcl xL , bag 1 , fas and fasL . ^^^ RESULTS : Of the investigated factors , bag 1 correlated positively with bax , bcl 2 , and fasL , and fasL correlated positively with fas and bax . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , when the deregulated c myc transgene was stably transduced into bone marrow cells from Fas ( lpr / lpr ) ( CD 95 receptor mutant ) and FasL ( gld / gld ) ( CD 95 ligand mutant ) mice , cell death was significantly suppressed relative to c myc transduced wild type bone marrow cells upon induction of differentiation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To investigate whether the Fas / Fas ligand ( FasL ) system is involved in the pathogenesis of HTLV 1 associated myelopathy ( HAM ) , expression of Fas / FasL in the spinal cord lesions of HAM patients was examined by immunohistochemistry and reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ The expressions of Fas / FasL in inactive chronic lesions were comparable to those of normal controls . ^^^ In normal controls , vascular endothelial cells constitutively displayed both Fas and FasL immunoreactivity , while microglia expressed FasL . ^^^ RT PCR confirmed constitutive expression of both Fas mRNA and FasL mRNA in the spinal cords of HAM patients , and in controls . ^^^ Our results indicate that Fas / FasL system is involved in the inflammatory process in the central nervous system of HAM patients . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We examined the expression of apoptosis , Fas , FasL , active caspase 3 and bcl 2 proteins in the amnion , placenta and decidua . ^^^ Fas , FasL , active caspase 3 , and bcl 2 specific bands did not show any significant differences between the two groups . ^^^ These findings demonstrate that apoptosis , Fas , FasL , caspase 3 , and Bcl 2 occur in mouse term placenta that is not involved in parturition . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Similarly , dialysis sera enhanced T cell Fas as well as FasL expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / Fas ligand ( Fas L ) death pathway is an important mediator of apoptosis . ^^^ Western blot and confocal microscopy analysis showed an increase of membrane Fas / Fas L when cells were induced into apoptotis by NBEC CM . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The seemingly opposing consequences of Fas / FasL interactions appear to be dependent on the context of the tumor or tissue microenvironment . ^^^ When put in the context of biologic interactions that take place at the tumor site , the Fas / FasL pathway emerges as a molecular mechanism , which contributes to immune privilege and tumor escape , but which can also enhance anti tumor inflammatory responses . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here we show that two such inhibitors , thrombospondin 1 and pigment epithelium derived factor , derive specificity for remodeling vessels from their dependence on Fas / Fas ligand ( FasL ) mediated apoptosis to block angiogenesis . ^^^ Expression of the essential partner of FasL , Fas / CD95 receptor , was low on quiescent endothelial cells and vessels but greatly enhanced by inducers of angiogenesis , thereby specifically sensitizing the stimulated cells to apoptosis by inhibitor generated FasL . ^^^ The anti angiogenic activity of thrombospondin 1 and pigment epithelium derived factor both in vitro and in vivo was dependent on this dual induction of Fas and FasL and the resulting apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
By contrast , Fas , FasL , C9neo , and activated caspase 3 immunoreactivities were negative in pathological areas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
MAIN OUTCOME MEASURE ( S ) : Testicular germ cell apoptosis ( percentages of apoptotic tubules and apoptotic cells ) was assessed by using DNA nick end labeling , and expression of Bcl 2 family , Fas FasL system , and p 53 was evaluated by using Western analysis . ^^^ CONCLUSION ( S ) : Germ cell apoptosis induced by heat exposure is mainly mediated by the Fas FasL system . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Effect of kidney tonifying and circulation promoting compound on transcription of T cell apoptosis related Fas and FasL genes in aged rats ] . ^^^ METHODS : GAPDH was used as an internal control gene , and semi quantitative analysis of the transcription of Fas and FasL genes was performed by using RNase protection assay . ^^^ RESULTS : The Fas / GAPDH and FasL / GAPDH optical density ( OD ) ratios was 0 . 81 + / 0 . 17 and 0 . 84 + / 0 . 12 in the aged control group , and 0 . 36 + / 0 . 16 and 0 . 26 + / 0 . 12 in the young control group , the difference between the two groups was significant . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD 97 , CD 95 and Fas L clearly discriminate between chronic pancreatitis and pancreatic ductal adenocarcinoma in perioperative evaluation of cryocut sections . ^^^ This study investigated the mRNA and protein expression of CD 97 , CD 95 and Fas L in snap frozen material obtained from human pancreatic ductal adenocarcinomas ( PDC ; n = 50 ) , tissues from pancreatitis ( PT ; n = 40 ) and normal pancreatic tissues ( PN ; n = 36 ) . ^^^ Reverse transcription polymerase chain reaction ( RT PCR ) analysis revealed that CD 97 , CD 95 and Fas L mRNA were expressed on a similarly high level in all tissues . ^^^ Our data demonstrate that CD 97 , CD 95 and Fas L can be used as additional markers to distinguish between pancreatitis and pancreatic duct cell carcinoma in cryocut sections . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A novel bystander effect involving tumor cell derived Fas and FasL interactions following Ad . ^^^ HSV tk / GCV and Ad . mIL 12 induced IFN gamma independently up regulated expression of FasL and Fas , respectively , studies examined tumor cell mediated death through Fas / FasL induced apoptosis as a mechanism of primary tumor growth suppression . ^^^ In FasL knockout mice , combination therapy maintained the superior results experienced in wild type mice , indicating that tumor cell , not host cell FasL , was responsible for Fas transactivation . ^^^ HSV tk / GCV + Ad . mIL 12 results in enhanced local growth control via apoptosis due to tumor cell expression of Fas and FasL and improved anti metastatic activity secondary to a strong NK response . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVE : To study the cell cycle block and apoptosis induced by hydroxycamptothecine ( HCPT ) in cultured rabbit lens epithelial cells ( RLECs ) and its affect on the gene expression of fas / fas L in RLECs . ^^^ Expression of Fas and Fas L was estimated by immunohistochemical staining . ^^^ The HCPT did not affect the gene expression of Fas / FasL . ^^^ CONCLUSIONS : HCPT not only induces mitotic block but also induces apoptosis of RLECs which is not mediated by the Fas / FasL signaling pathway . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Peripheral LPS administrations up regulate Fas and FasL on brain microglial cells : a brain protective or pathogenic event . ^^^ We evaluated the effect of single or repeated intraperitoneal daily LPS injections on expression of Fas / FasL system within the brain . ^^^ Results obtained , utilizing real time quantitative RT PCR , show that , while a bolus injection of LPS robustly increases hippocampal Fas , but not FasL , mRNA expression , repeated LPS administrations also induce FasL up regulation . ^^^ Immunofluorescence studies demonstrated , in turn , an increased number of Fas and FasL immunoreactive microglial cells within the brain parenchyma . ^^^ The increase in FasL immunoreactivity was , in contrast to Fas , still evident 2 weeks following LPS wash out . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Some reports have indicated that ceramide is either a primary signaling molecule in Fas induced cell death , or that it functions upstream of Fas by increasing FasL expression . ^^^ Because of the parallel resistance of the mutant clones to Fas and to ceramide induced apoptosis , our data support the notion that ceramide is a second messenger for the Fas / FasL pathway and that serum withdrawal , through production of ceramide , shares a common step with the Fas mediated apoptotic pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : Fas and FasL expressions were examined by immunohistochemical technique in 44 RCC patients , with the Ki 67 expression and apoptosis of tumor infiltrating lymphocytes ( TIL ) monitored simultaneously . ^^^ FasL function was assessed by in vitro co culture assays using renal cancer cells 786 0 and Fas sensitive Jurkat T cells . ^^^ The expression of FasL and the apoptotic rate of TIL in RCC gave a positive correlation ( r = 0 . 96 , P < 0 . 01 ) . ( 3 ) Fas expression rate in 786 0 cells was 13 . 7 % . ^^^ FasL expressed by 786 0 cells was able to induce apoptosis of Jurkat T cells in co culture assays and the apoptosis of Jurkat T cells was significantly lowered after blocking the effect of FasL with Fas neutralizing antibody NOK 2 , giving the apoptotic rates of 14 . 9 % and 2 . 0 % , respectively , the difference therein is statistically significant ( P < 0 . 01 ) . ^^^ CONCLUSION : Down regulation of Fas expression and up regulation of FasL expression are the mechanisms through which the RCC cells escape from immune attack . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We investigated the role of both types of cytokines on the expression and function of the Fas / Fas ligand ( FasL ) apoptotic pathway in trophoblast cells . ^^^ Fas / FasL mRNA and protein expression levels were determined using reverse transcription polymerase chain reaction ( RT PCR ) and Western blot analysis , respectively . ^^^ Trophoblast cells normally express FasL , but low levels of Fas , and they are resistant to Fas mediated apoptosis . ^^^ This `` trophoblast cytokine Fas / FasL triad ' ' determines the ability of the Fas / FasL system to regulate trophoblast viability and , consequently , the success or failure of pregnancy . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The hypothesis that FasL expression by tumor cells may impair the in vivo efficacy of antitumor immune responses , through a mechanism known as ' Fas tumor counterattack , ' has been recently questioned , becoming the object of an intense debate based on conflicting results . ^^^ Isolated melanosomes express FasL , as detected by Western blot and cytofluorimetry , and they can exert Fas mediated apoptosis in Jurkat cells . ^^^ We additionally show that melanosome containing multivesicular bodies degranulate extracellularly and release FasL bearing microvesicles , that coexpress both gp 100 and CD 63 and retain their functional activity in triggering Fas dependent apoptosis of lymphoid cells . ^^^ Hence our data provide evidence for a novel mechanism potentially operating in Fas tumor counterattack through the secretion of subcellular particles expressing functional FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We have further explored this model by examining the role of Fas / Fas ligand ( FasL ) mediated apoptosis . ^^^ Using i . v . injection of trinitrophenyl coupled splenocytes ( TNP spl ) as tolerogen , we found that Fas signaling for apoptosis in the spleen cells delivered by FasL in the recipient is the critical event . ^^^ The requirement for Fas and FasL was overcome by prior induction of apoptosis in TNP spl , making the tolerogen 100 times more potent . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : Normoxic or hypoxic ( 22 h , 1 % O ( 2 ) ) cultured NRVM were exposed to recombinant Fas L ( rFasL ) for 7 h , and apoptosis measured thereafter . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas , FasL , TNF alpha and TNFR p 55 expression , measured by flow cytometry , ELISA and / or RT PCR , were significantly elevated in aged mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These include alterations in DNA ploidy , cellular proliferation markers ( PCNA , Ki 67 , Mcm 2 , MIB 1 , MIA , and CSE1L / CAS protein ) , nuclear morphology , the p 53 gene and its related molecule MD M 2 , other cell cycle regulators ( cyclin A , cyclin D , cyclin E , cdc 2 , p 27 , p 73 ) , oncogenes and their receptors ( such as ras , c myc , c fms , HGF , c met , and erb B receptor family members ) , apoptosis related factors ( Fas and FasL ) , as well as telomerase activity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
ANG 2 also upregulated the expression of Fas , FasL , and Bax and downregulated the expression of Bcl 2 in GECs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Blood and liver were analyzed for plasma aminotransferase activity , liver histology , liver apoptotic nuclei , mRNA of several cytokines ( tumor necrosis factor [ TNF ] alpha , interleukin [ IL ] 1beta , IL 6 , and IL 10 ) , apoptotic ligands ( TRAIL ) , cytokine receptors ( TNFRp 55 ) , pro and antiapoptotic regulators / adaptors ( Fas receptor , FasL , FADD , TRADD , RIP , Bak , Bax , Bcl 10 , Bcl 2 and Bcl w ) , and caspase 8 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , in vivo the Fas receptor is activated by its natural ligand , Fas L , whereas anti Fas antibodies are not a physiologic stimulus . ^^^ We therefore have assessed the anti apoptotic effects of UDCA and other bile acids in a novel coculture model where apoptosis is induced in murine hepatocytes by membrane bound Fas L expressing fibroblasts . ^^^ Primary hepatocytes were cultured overnight on collagen coated coverslips with increasing concentrations of different bile acids and overlaid with either NIH 3T3 Fas L ( + ) or Fas L ( ) expressing fibroblasts . ^^^ Fas L protein expression and Fas trimerization were evaluated by Western blot analysis . ^^^ UDCA ( up to 100 micromol / L , P < . 0001 ) , TUDCA ( up to 400 micromol / L , P < . 0001 ) , and TCDCA ( up to 200 micromol / L , P < . 0001 ) , but not TCA ( up to 500 micromol / L ) , significantly protected hepatocytes in Fas L ( + ) cocultures . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cytolytic cells , when expressing the CD 95 ligand ( Fas L ) molecule on the cell membrane , are able to kill CD 95 ( Fas ) expressing target cells . ^^^ Although cultured epidermal keratinocytes ( KC ) have been shown to express Fas L , and normal skin has been shown to bear Fas L mRNA , efforts so far to find possible constitutive Fas L expression on the cell membrane by resting KC in normal human epidermis ( i . e . in a functionally active location ) have been inconclusive . ^^^ OBJECTIVES : The aim of the present study was therefore to show the constitutive expression of Fas L on the plasma membrane of KC . ^^^ CONCLUSIONS : Although scanty , the constitutive Fas L expressed on the surface of KC can bind Fas expressed by possible occasional inflammatory cells entering the epidermis , and kill them , so preventing inflammation . ^^^ Fas L expressing KC could moreover induce apoptosis of epidermal cells bearing viral or neoplastic antigens . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Analysis of T cells to identify the potential molecular pathway of the parasite induced apoptosis showed increases in the expression of Fas , FasL , and the Fas associated death domain . ^^^ Blocking of FasL with a fusion protein reversed the parasite induced apoptosis , suggesting a role for the Fas / FasL mediated pathway in the parasite induced T cell apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A comparative analysis of the expression of Fas and FasL , the antiapoptotic molecule Bcl 2 , and apoptosis in both thyrocytes and thyroid infiltrating lymphocytes ( TILs ) from patients with either Graves ' disease ( GD ) or Hashimoto ' s thyroiditis ( HT ) was performed . ^^^ GD thyrocytes expressed less Fas than HT thyrocytes , whereas GD TILs had higher levels of Fas and FasL than HT TILs . ^^^ Our findings suggest that in GD thyroid the regulation of Fas / FasL / Bcl 2 favors apoptosis of infiltrating lymphocytes . ^^^ Moreover , the reduced levels of Fas / FasL and increased levels of Bcl 2 should favor thyrocyte survival and hypertrophy associated with stimulatory thyroid stimulating hormone receptor antibodies . ^^^ In contrast , the regulation of Fas / FasL / Bcl 2 expression in HT can promote thyrocyte apoptosis via homophylic Fas FasL interactions , and a gradual reduction in thyrocyte numbers leading to hypothyroidism . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Defining the roles of perforin , Fas / FasL , and tumour necrosis factor alpha in T cell induced mucosal damage in the mouse intestine . ^^^ The role of perforin , Fas / Fas ligand ( FasL ) , tumour necrosis factor alpha ( TNF alpha ) , and interferon gamma ( IFN gamma ) in T cell induced mucosal damage was assessed using selected immunodeficient mouse strains . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The role of apoptosis and contribution of Fas / FasL systems in the pathogenesis of Sjogren ' s syndrome ( SS ) are still controversial . ^^^ With serial sections , we explored apoptosis assessed by the dUTP nick end labeling ( TUNEL ) method and expression of Fas and FasL by immunohistochemistry , and compared their distribution in minor salivary gland ( MSG ) of SS and sialolithiasis ( SIL ) patient tissues . ^^^ Fas and FasL were co localized in ductular and acinar cells of SS and SIL TUNEL+ cells co distributed with the Fas and FasL expressing cells in ductular and acinar cells of SS in the vicinity of lymphocytic infiltration , while not in those of SIL Moreover , to morphologically confirm apoptosis , we identified TUNEL positive ( + ) cells in the MSGs of SS at the ultra structural level by applying an inversion method to paraffin embedded sections stained by TUNEL method . ^^^ These findings suggest that Fas and FasL expressed in ducts and acini of chronic sialadenitis in SS patients induce apoptosis , possibily in an autocrine and / or paracrine manner . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The apoptosis percentage , cell cycle phase distribution and expression of Fas / FasL gene were estimated by flow cytometry ( FCM ) . ^^^ As ( 2 ) O ( 3 ) up regulated Fas gene expression , but did not affect FasL gene expression in both cell lines without significant difference ( P > 0 . 05 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Additional studies demonstrate that isolated CCR 5 activation by R 5 Env leads to both de novo expression of FasL and induction of susceptibility to Fas mediated apoptosis in resting primary CD 4 T cells . ^^^ CONCLUSIONS : These results ascribe to CCR 5 a novel role in activating the Fas pathway and caspase 8 as well as triggering FasL production when activated by R 5 Env , ultimately causing CD 4 T cell death . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The paraffin sections were used to determine apoptotic cells by TdT mediated dUTP biotin nick end labeling method , to identify bcl 2 , bax , fas , fasL and proliferating cell nuclear antigen ( PCNA ) by immunohistochemistry , to demonstrate fas and fasL mRNA by in situ hybridization . ^^^ The antigen of bax , fas , fasL were present in syncytiotrophoblast cells and decidua with lower amount . ^^^ The expression of fas , fasL and bax was also higher than that of normal . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CONCLUSION : The hilar cholangiocarcinoma eludes immunological surveillance by inducing , via the Fas / FasL system , the apoptosis of activated lymphocytes . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The effect of the AGP at the molecular level was associated with the low protein expression of the c myc and bcl 2 genes and the high protein expression of the p 53 , bax , fas and fas L genes , as well as the cell factor TGF beta ( 1 ) . ^^^ Hispidus Hoo polysaccharides selectively inhibited the proliferation , the colony forming ability , and the viability and function of human gastric cancer cells through the low protein expression of c myc , bcl 2 and the high protein expression of p 53 , fas , fas L and the cell factor TGF beta ( 1 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the role of Fas / Fas ligand ( FasL ) in tum orgenesis , immune escape , counterattack in colonic cancer . ^^^ METHODS : Fas and FasL were measured by immunohitochemistry in 52 colon cancer , 27 adenomas , 28 ulcerative colitis ( UC ) , 30 normal colon tissues and 23 lymph node metastases of colon cancer . ^^^ Compare of Fas , FasL was highest in colon cancer tissue , lowest in the normal tissue . ^^^ The FasL in adenomas and UC were higher than that in the normal tissue . ( 2 ) Expression of Fas / FasL was not correlated with the typ e of tumor histology , but it was correlated with Dukes ' stage , tumor differentiation and lymph node metastasis . ( 3 ) In the same tumor tissue , FasL expression was not even . ^^^ CONCLUSION : Fas / FasL play an important role in tumorgenesis , immune escape , counterattack in colon cancer . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of both proapoptotic ( Fas , FasL , Bax , p 53 ) and antiapoptotic ( Bc 12 ) cellular proteins was determined by immunohistochemistry . ^^^ In DSS rats , the epithelial apoptotic index increased 20 fold after the first cycle and 120 fold after the second and third cycles compared with the controls ; in the same way , the expression index of proapoptotic proteins ( Fas , FasL , Bax , p 53 ) dramatically increased . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , CR increased the proliferative response of splenic lymphocytes and decreased the Fas ( CD 95 ) and Fas L protein expression in CD4+ lymphocytes from old mice . ^^^ Higher levels of Fas and Fas L expression were observed in old mice compared to young mice . ^^^ In summary , CR resulted in decreased apoptosis accompanied by alterations in Fas , Fas L , and Bcl 2 expression in old mice , increased life span , and delayed onset of kidney disease . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The role of the Fas / FasL system in ANCA associated vasculitis is unclear . ^^^ Expression of Fas and FasL in renal biopsy specimens was studied using immunohistochemistry . ^^^ No alterations of Fas and FasL expression were seen in renal biopsy specimens . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These results suggest that the Fas / FasL pathway may play a crucial role in the induction of apoptosis in N . caninum and T . gondii infected cells mediated by IFN gamma . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Using western blot analysis , we also examined the expression of the apoptosis inducing system of the Fas death receptor protein and its ligand , FasL , in these cells . ^^^ To assess the involvement of Fas and FasL in the induction of apoptosis in LTED cells , we used activating anti Fas antibodies and the universal caspase inhibitor Z VAD . ^^^ Both LTED and MCF 7 cells expressed FasL , but only LTED cells expressed Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The interaction of CD 44 with fragmented hyaluronan on rheumatoid synovial cells induces expression of VCAM 1 and Fas on the cells , which leads to Fas mediated apoptosis of synovial cells by the interaction of T cells bearing FasL . ^^^ On the other hand , engagement of CD 44 on tumor cells derived from lung cancer reduces Fas expression and Fas mediated apoptosis , resulting in less susceptibility of the cells to CTL mediated cytotoxicity through Fas FasL pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The APO 1 / Fas ligand ( FasL ) and tumor necrosis factor alpha ( TNF alpha ) are two functionally related molecules that induce apoptosis of susceptible cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The death response involved two major splenic gammadelta T cell subsets and was Fas / Fas ligand ( Fas L ) dependent . ^^^ Among T cells isolated from the Listeria infected spleen , Fas L was almost exclusively expressed in gammadelta T cells . gammadelta T cells coexpressed Fas and Fas L , suggesting activation induced suicide as a mechanism of their death . ^^^ In vivo treatment with an antibody specific for CD3epsilon induced activation , preferential Fas L expression and apoptosis of gammadelta T cells , resembling the response pattern in listeriosis , whereas antibodies specific for T cell receptor beta ( TCR beta ) or TCR delta did not , suggesting that the complete response seen in listeriosis requires both gammadelta TCR engagement and additional stimuli . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recent studies have provided evidence that Fas and FasL interactions are important in the control of malignant disease and that changes in the level of Fas expression can determine immune escape and therapeutic responses . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptotic signalling , particularly in the Fas Fas ligand ( FasL ) system , was studied in a mouse osteoblastic cell line , MC3T3 E 1 . ^^^ A combination of the cytokines tumour necrosis factor alpha , interleukin 1beta and interferon gamma activated the Fas FasL dependent cell death system . ^^^ Exogenous FasL caused a decrease in cell viability and a large increase in apoptotic cell death in cells pre treated with cytokines , indicating that the Fas FasL system has the potential to cause apoptosis in osteoblastic cells . ^^^ Taken together , these findings show that cytokine induced apoptotic cell death was mediated by the autocrine or paracrine Fas FasL system in mouse osteoblastic cells , and suggest that cytokine induced apoptosis could have an important role in localised bone destruction associated with inflammatory bone diseases such as periodontal disease . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cells behaving badly : a theoretical model for the Fas / FasL system in tumour immunology . ^^^ One proposed mechanism of tumour escape from immune surveillance is tumour up regulation of the cell surface ligand FasL , which can lead to apoptosis of Fas receptor ( Fas ) positive lymphocytes . ^^^ Based upon this ' counterattack ' , we have developed a mathematical model involving tumour cell lymphocyte interaction , cell surface expression of Fas / FasL , and their secreted soluble forms . ^^^ The model predicts that ( a ) the production of soluble forms of Fas and FasL will lead to the down regulation of the immune response ; ( b ) matrix metalloproteinase ( MMP ) inactivation should lead to increased membrane FasL and result in a higher rate of Fas mediated apoptosis for lymphocytes than for tumour cells . ^^^ Also , Fas / FasL interactions may have an impact on the outcome of numerous ongoing immunotherapeutic trials since the final common pathway of all these approaches is the transduction of death signals within the tumour cell . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( APO 1 / CD95 ) is a type 1 membrane protein that is capable of initiating an apoptosis signaling pathway when bound to its ligand ( FasL ) . ^^^ We undertook this study to test the hypothesis that Fas FasL mediated apoptosis plays a role in IL 12 induced tumor regression . ^^^ Western blot and immunohistochemical assays were used to evaluate Fas and FasL protein expression . ^^^ Fas and FasL proteins were increased approximately twofold in the RM 9 IL 12 tumors compared with the RM 9 control tumors as determined by Western blot and immunohistochemical analyses ( P < 0 . 05 ) . ^^^ CONCLUSION : The Fas FasL mediated apoptosis pathway may contribute to the IL 12 induced rejection of prostate carcinoma . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of IGF 1 , TGF beta and Fas L in granulosa cells of ovarian follicle with relation to the onset of atresia in rats ] . ^^^ This study was designed to investigate the effects of IGF 1 , TGF beta and Fas L on the sustaining of granulosa cells of ovarian follicle and the modulation of apoptosis of those cells , and to understand the molecular mechanisms of ovarian follicle atresia . ^^^ The expression of IGF 1 , TGF beta , Fas L and their receptors was displayed by immunostaining . ^^^ The immunoreactive products of IGF 1 , IGF IR , TGF beta , TGF beta R , Fas and Fas L could be seen in the granulosa cells of healthy antral follicles . ^^^ TGF beta , Fas L and Fas might mediate apoptosis of the granulosa cells in antral follicles , causing follicle atresia . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The apoptosis in A 431 cells was inhibited by anti FasL antibody which neutralized the cytotoxic effect of FasL , indicating that the Fas / FasL system was involved . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We studied Fas / FasL , Bcl 2 , and M 30 CytoDeath in five cases of normal thymus and 41 cases of thymic epithelial tumors ( TETs ) . ^^^ In normal thymus , Fas was expressed in all epithelial cells , but not in thymic lymphocytes ; FasL was weakly expressed only in medullary epithelium and Hassal ' s corpuscles . ^^^ In TETs , Fas was expressed in all epithelial cells and lymphocytes , while FasL was differently expressed in epithelial cells of different subtypes of TETs , i . e . , type A ( 2 / 2 ) , AB ( 12 / 12 ) , B 1 ( 0 / 9 ) , B1 / B2 ( 0 / 3 ) , B 2 ( 0 / 1 ) , B2 / B3 ( 1 / 3 ) , B 3 ( 6 / 10 ) and C ( 1 / 1 ) , but not in lymphocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Flow cytometry and ELISA showed FasL up regulation and increased IFN gamma synthesis in IL 12 treated T cells , while Fas and TNF R 1 showed little change . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The present study aimed to carry out the comparative analysis of the molecular markers expression ( P 53 , Ki 67 , Her 2 / neu , Bcl 2 , Bax , ER , FasL and CD 95 ) at the cytologic and the correspondent histologic samples . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The aim of this study is to investigate the effects of GnRH a on uterine leiomyomas by profiling the expression levels of apoptosis related molecules such as Fas / Fas ligand ( FasL ) , caspases 3 , 6 , 7 , 8 , 9 , and 10 , and Bcl 2 from specimens of 20 patients receiving Leuplin Depot ( LA ) , a long acting GnRH a , of 3 doses before myomectomy , as well as 24 controls . ^^^ Unlike the case of FasL and caspase 3 mentioned above , no significant difference was found between leiomyomas and homologous myometria in the expressions of Fas and caspases 6 , 7 , 8 , 9 , and 10 . ^^^ Immunohistochemical analysis showed that both Fas and FasL were localized predominantly in cytosol . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Characterization of Fas / FasL expression and the frequency of apoptotic cell death was performed by immunohistochemistry and TUNEL staining . ^^^ Reverse transcriptase polymerase chain reaction , by the use of Fas and FasL specific cDNA probes , was performed on isolated hepatocytes of tolerized and rejected livers at various time points after transplantation . ^^^ The underlying mechanisms of immune privilege observed with liver allografts appear to share characteristics of clonal exhaustion suggesting that alloreactive lymphocytes are depleted by AICD via the FasL / Fas signal transduction pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Human macrophage induced vascular smooth muscle cell apoptosis requires NO enhancement of Fas / Fas L interactions . ^^^ OBJECTIVE : We have previously shown that macrophages induce vascular smooth muscle cell ( VSMC ) apoptosis in vitro by cell cell proximity and Fas L / Fas interactions . ^^^ In isolated macrophages , NOS inhibitors reduced and NO donors increased surface Fas L , indicating an NO dependent autocrine enhancement of macrophage surface Fas L . ^^^ CONCLUSIONS : Together , these data indicate that macrophage derived NO is required for macrophage induced VSMC apoptosis and that it acts by enhancing Fas L / Fas interactions . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Consequently , the death and survival signalling arms within germinal centres predominantly reside on the timely and controlled expression of Fas and its ligand ( FasL ) , and CD 40 and CD 154 , respectively . ^^^ In keeping with this notion , lymphoproliferation or deficient immunity are documented landmarks of inactivation of either the Fas / FasL or CD40 / CD154 signalling pathways . ^^^ The first is an idealistic scenario , in which a discriminatory and co ordinate signalling initiated by the CD40 / CD154 and Fas / FasL pairs , respectively , leads the rescue of the functional B cell repertoire and the elimination of the abnormal phenotype . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CD40 / CD40 ligand pair is also a strong proatherogenic system . sPLA 2 produced an increase of the surface expression of CD 40 in THP 1 monocytes and enhanced the effect of CD 40 ligation on the expression of both Fas and FasL , thus indicating the existence of a positive cooperation between sPLA 2 and different elements of the TNF receptor superfamily . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To this end , C57BL / 6 wild type ( + / + ) , Fas deficient ( C57BL / 6 lpr / lpr ) , and FasL deficient ( C57BL / 6 gld / gld ) mice were treated with various concentrations of E 2 , including 75 , 25 , 5 , 1 , or 0 . 1 mg / kg body weight or the vehicle . ^^^ Reverse transcriptase polymerase chain reaction data also demonstrated the increased expression of Fas and FasL genes following E 2 treatment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , Taxol had no effect on the levels of Fas and FasL proteins and neither antagonistic , anti Fas antibody affected Taxol induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expressions of Fas and FasL in the decidual tissues at different stages of gestation were examined by in situ hybridization and immunohistochemistry . ^^^ RESULTS : On day 41 of normal pregnancy , evident apoptosis in the decidual tissues occurred with significantly enhanced Fas and FasL expressions , while obvious reduction in both the apoptotic cells and Fas and FasL expression was observed on day 54 . ^^^ In women with spontaneous abortion , increased apoptotic cells were present in the decidual tissues around day 55 of gestation when significantly enhanced Fas and FasL mRNA and protein expressions also took place , in comparison with those of healthy pregnant women on day 54 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis of the adherent cells was markedly inhibited by anti Fas ligand ( FasL ) Ab . ^^^ These results implied that apoptosis of the adherent cells in bone marrow cells might be caused by interaction between TNF alpha induced Fas on the adherent cells and IL 12 induced FasL on the nonadherent cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , membrane bound FasL as expressed on cell derived vesicles was fully competent in transducing Fas mediated signals for apoptosis and NF kappaB nuclear translocation . ^^^ Membrane bound FasL induces powerful Fas mediated signals because it possesses both Fas focusing and signal transducing functions . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cytokines of the T helper 1 response IFN gamma , IL 12 , and IL 18 regulate the expansion of donor and host cells via the induction of Fas and FasL and subsequent apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
One critical mechanism of immune privilege is utilization of Fas / FasL mediated apoptosis to delete the invading T cells at the immune privilege sites . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas is a widely expressed cell surface receptor that can initiate apoptosis when activated by its ligand ( FasL ) . ^^^ Myocyte killing by FasL is a specific event , because it does not occur in lpr ( lymphoproliferative ) mice that lack functional Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Although DU 145 prostate cancer cells are resistant to exogenously applied Fas agonist CH 11 ( anti Fas monoclonal antibody ) , Fas resistance can be overcome using a FasL expressing adenovirus ( AdGFPFasL ( TET ) ) [ Hyer et al . , Molecular Therapy , 2000 ; 2 : 348 58 ( ref . 12 ) ] . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In UNPC tissue sections from 20 cases , we conducted immunohistochemistry to detect Fas and FasL , in situ hybridization to detect Epstein Barr virus encoded small RNA ( EBER ) , and immunohistochemistry for single stranded DNA ( ssDNA ) to detect apoptotic cells . ^^^ Fas was detected in 17 / 20 ( 85 % ) , FasL in 15 / 20 ( 75 % ) , and EBER in 16 / 20 ( 80 % ) . ^^^ Interestingly , despite Fas and FasL co expression in UNPC cells ( Fas+ / FasL+ cases = 13 / 20 or 65 % ) , apoptotic UNPC cells were significantly lower in Fas+ / FasL+ than in other cases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activation induced apoptosis is contingent upon caspase activation and this is mediated primarily by Fas / Fas ligand ( FasL ) interactions that , in turn , are optimized by p 38 mitogen activated protein kinase ( MAPK ) regulated signals . ^^^ Although T cells from mice bearing mutations in Fas ( lpr ) or FasL ( gld ) are more resistant to activation induced cell death ( AICD ) than normal T cells , a significant proportion of CD 8 ( + ) T cells and to a lesser extent CD 4 ( + ) T cells from mutant mice die after TCR religation . ^^^ A related Fas and caspase independent , nonapoptotic death process is revealed in wild type ( WT ) CD 8 ( + ) T cell blasts following TCR ligation and treatment with caspase inhibitors , the p 38 MAPK inhibitor , SB 203580 , or neutralizing anti FasL mAb . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
After treatment with As2O3 , the changes of Fas , FasL , and nm 23 gene expressions were estimated by flow cytometry ( FCM ) . ^^^ As2O3 up regulated Fas and nm 23 gene expressions of abdominal cavity implanted tumors ( P < 0 . 05 ) , but did not affect FasL gene expression ( P > 0 . 05 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
One way to induce apoptosis in keratinocytes is through activation of the cell surface receptor Fas ( CD 95 ) , either with the ligand ( FasL ) or directly with UV radiation . ^^^ OBJECTIVES : To investigate the regulation of Fas and FasL expression in human skin and the formation of apoptotic cells after in vivo exposure to UVB or long wave UVA radiation . ^^^ Expression of Fas and FasL was demonstrated by immunohistochemistry on cryostat sections . ^^^ The number of apoptotic epidermal cells did not correlate with expression of Fas or FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , vanadate induced FasL production , Fas ( CD 95 ) aggregation , and its association with the Fas associated death domain ( FADD ) , as well as the activation of caspase 8 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Because CASP 8 is a key component of the death inducing signaling complex ( DISC ) when specific death receptors ( including DR 4 , DR 5 , FAS ) are activated by their specific ligands ( TRAIL / FASL ) , we examined expression of the components of the DISC complex in lung cancer cell lines . ^^^ Analyses of other DISC components showed significantly higher rates of loss of expression of CASP 10 , DR 5 , FAS and FASL in SCLC compared to NSCLC . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The aims of this study were to determine whether human gastric adenocarcinomas express FasL or Fas , whether FasL expression is associated with increased apoptotic induction , especially , tumor infiltrating lymphocyte ( TIL ) and whether apoptotic induction is associated with the tumor stage and histologic type . ^^^ Immunohistochemical staining for Fas , FasL and CD 45 , TACS trade mark in situ apoptosis detection kit , and double staining with the observation under a confocal scanning laser microscope were employed . ^^^ Co expression of FasL and Fas , which occurrs over large areas of the tumors , did not result in an enhanced rate of tumor cell apoptosis . ^^^ In addition , tumor stage and other prognostic factors were not associated with Fas and FasL expressions , number of TIL and apoptotic induction . ^^^ This finding suggests Fas mediated apoptotic depletion of TIL in response to FasL expression in stomach cancers , and provides evidence to support the Fas counterattack theory as a mechanism of immune escape in gastric cancer . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Some tumour cells expressed FasL , but not Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We have recently demonstrated that despite the expression of Fas and FasL , the incidence of apoptosis is not increased in SS patients compared with control individuals . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Suppression of Fas FasL induced endothelial cell apoptosis prevents diabetic blood retinal barrier breakdown in a model of streptozotocin induced diabetes . ^^^ In the current study , diabetic vascular permeability ( blood retinal barrier breakdown ) is demonstrated to result from a leukocyte mediated Fas FasL dependent apoptosis of the retinal vasculature . ^^^ Following the onset of streptozotocin induced diabetes , FasL expression was increased in rat neutrophils ( P < 0 . 005 ) and was accompanied by a simultaneous increase in Fas expression in the retinal vasculature . ^^^ Taken together , these data are the first to identify leukocyte mediated Fas FasL dependent retinal endothelial cell apoptosis as a major cause of blood retinal barrier breakdown in early diabetes . ^^^ These data imply that the targeting of the Fas FasL pathway may prove beneficial in the treatment of diabetic retinopathy . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Effects of cyclosporin A on expression of FasL and Fas in the contralateral testis after the unilateral testis injured in KM mouse ] . ^^^ OBJECTIVES : To investigate the effects of Cyclosporin A ( CsA ) on spermatogenesis and expression of FasL and Fas in the contralateral testis after the unilateral testis was injured . ^^^ Expression of FasL and Fas was performed by immunohistochemistry ( SP method ) . ^^^ Expression of FasL and Fas in group D decreased significantly compared with group B ( 24 . 3 + / 7 . 0 vs 37 . 8 + / 5 . 8 and 17 . 8 + / 4 . 3 vs 32 . 4 + / 3 . 6 , P < 0 . 05 ) . ^^^ CONCLUSIONS : CsA decreased expression of Fas and FasL and maintained spermatogenesis in the contralateral testis after the unilateral testis was injured by glacial acetic acid . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of Fas receptor ligand ( FasL ) is specifically detected in cells under suspension conditions or treated with cytochalasin D . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
More specifically , in this report , we investigated whether apoptosis induced by capecitabine was mediated by the Fas / FasL system . ^^^ Both Fas and FasL mRNA expression were triggered after exposing TP+ cells to the drug . ^^^ This implication of Fas in Xeloda induced apoptosis was next confirmed by using antagonistic anti Fas and anti FasL antibodies that proved to reverse capecitabine antiproliferative activity , thus highlighting the key role that Fas could play in the optimization of an antitumor response to fluoropyrimidine drugs . ^^^ Our data , therefore , show that TP plays a key role in the capecitabine activity and that the Fas / FasL system could be considered as a new determinant for Xeloda efficacy . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
SMNC3H Fas ( gld , gld ) ( gld ) mice that express a dysfunctional form of FasL still undergo significant apoptosis , albeit at a lower incidence than seen in B 6 mice , following mono ( 2 ethylhexyl ) phthalate ( MEHP ) induced Sertoli cell injury . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Adriamycin induced endothelial cell apoptosis is mediated by caspase activation but is Fas / FasL signal pathway independent . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We also investigated Fas expression and FasL mRNA expression as well as the ability of an IgM anti Fas antibody to induce apoptosis . ^^^ However , we could not find any difference between patients and normals as regards the expression of Fas and of FasL mRNA , even if the cross linking of the Fas molecule induced apoptosis in PBMC from patients , whereas it failed to induce cell death in normals . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The effect of dialysis sera and membranes was evaluated on monocyte apoptosis as well as monocyte expression of proapoptotic proteins such as Fas and FasL . ^^^ Dialysis membranes also modulated monocyte expression of both Fas and FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Leukemic cells from patients expressed high level FasL cause apoptosis of autologous activated T cells via the Fas / FasL pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of Fas , FasL and Bcl 2 on RMA cells during the process of apoptosis induced by chemotherapeutic drugs ] . ^^^ The objective of the study is to explore the effect of Fas , FasL and Bcl 2 on the process of apoptosis induced by chemotherapeutic drugs through detecting the expression of Fas , FasL and Bcl 2 on murine lymphoma cell line RMA . ^^^ The effect on apoptosis was observed and the expression of Fas and FasL mRNA as well as the expression of Fas and Bcl 2 antigen were measured . ^^^ DEX and VP 16 could promote apoptosis of RMA cells while upregulating the expression of Fas and FasL without affecting the expression of Bcl 2 . ^^^ ATRA downregulated the expression of Bcl 2 without any change of Fas and FasL , and no apoptosis of RMA cells induced by ATRA was observed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and Fas L expression in human adenocarcinoma of uterine cervix ] . ^^^ OBJECTIVE : To study the significance of Fas and Fas L expression in adenocarcinoma of uterine cervix . ^^^ METHODS : Both carcinoma tissue and their surrounding tissues from 36 patients with adenocarcinoma of uterine cervix , previously untreated either by radiation or chemotherapy , were studied for the expression of Fas and Fas L by immunohistochemical stain with DNA apoptosis fragment detected by TUNEL . ^^^ The Fas L expression was detected in all adenocarcinomas while there was only 1 weakly stained in the normal ones . ^^^ No significant difference was found in the expression of Fas L in carcinomas with different degrees of differentiation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The effect of the Fas / FasL pathway during chemotherapeutic drug induced apoptosis of leukaemeic cells . ^^^ The mechanism of chemotherapeutic drug induced apoptosis in leukaemic cells was studied to further investigate whether Fas / FasL system was involved in apoptosis induced by chemotherapeutic drugs and assess their effects when used in combination with soluble FasL ( sFasL ) . ^^^ It was concluded that chemotherapeutic drug induced apoptosis in human leukaemic cells ( UG 37 , HL 60 ) is independent of the Fas / FasL system , but combination of sFasL and drug treatment produces a synergistic cytotoxic effect on human leukaemic cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The results showed that the brain tissue neurons treated by traumatic brain injury underwent morphological changes of apoptosis , the DNA presented `` ladder ' ' break , the rate of neuronal apoptosis at different times ranged from 9 . 8 % to 14 . 0 % , but that of the control group was 1 . 7 % and the expressions of related apoptosis genes ( c myc , fas and fasL ) were increased . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
One mechanism was illustrated by the ability of Egr 1 to inhibit CD 95 ( Fas / Apo ) expression , leading to insensitivity to FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In conclusion , our data provide evidence that TGFbeta 1 exerts an autocrine pro apoptotic effect on human endometrial stroma , via the FasL / Fas system . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Therapeutic effect of xinfeng capsule in treating adjuvant arthritis in rats and its effect on fas , fasL and bcl 2 expression in synovial membrane ] . ^^^ OBJECTIVE : To observe the therapeutic effect of Xinfeng Capsule ( XFC ) in treating adjuvant arthritis of rats and its effect on fas , fasL and bcl 2 expression in synovial membrane . ^^^ The arthritis index ( AI ) , change of body weight ( BW ) of rats were recorded , and the expressions of fas , fasL and bcl 2 in rats ' synovial membrane were determined . ^^^ Compared with the model group , fasL expression was increased in the XFC group significantly ( P < 0 . 05 ) , but bcl 2 expression decreased , fas expression showed insignificant difference ( P > 0 . 05 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The status of Fas , FasL and caspase 3 in the two cell lines were analyzed with immunocytochemical staining and Western blot hybridization , and their potential link to MMC induced cell death was investigated by treating the cells with anti Fas antibody ( 150 ng / ml ) and by incubating the cells with an inhibitor of caspase 3 related proteases Ac DEVO CHO ( 250 micro M ) 1 h before 100 micro g / ml MMC treatment . ^^^ Constitutive soluble and membrane Fas and FasL were found in both cell lines , and caspase 3 could be upregulated after MMC treatment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
AIM : To investigate the effects of angiotensin converting enzyme inhibitor ( ACEI ) on apoptosis and the expression of Fas and Fas L in the kidney of diabetic rats . ^^^ Flow cytometry and immunohistochemistry were used to detect the expression of Fas and Fas L . ^^^ RESULTS : Compared with those in the kidneys of control group , apoptotic cells were more in number and the expression of Fas and Fas L was higher in the diabetic kidneys ( P < 0 . 05 ) . ^^^ The number of apoptotic cells and the level of expression of Fas and Fas L were reduced by benazepril treatment ( P < 0 . 05 ) . ^^^ CONCLUSION : Angiotensin converting enzyme inhibitor benazepril showed some renal protective effect on diabetic nephropathy , partly through inhibiting apoptosis by down regulating Fas and Fas L expression . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : Expressions of T cell apoptosis promoting and inhibiting genes , including Fas , FasL , Bcl 2 , Bax , TNFR 1 and TNFR 2 , as well as activity of cysteine proteinase in cascade connection , such as Caspase 8 and Caspase 3 were determined by TUNEL labeled flow cytometry and fluorescence real time quantitative RT PCR technique . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the effect of Shenmai Injection ( SMI ) and aminophylline on small airway smooth muscle cell ( SASMC ) apoptosis and the Fas / FasL expression in the papain induced emphysema model rats . ^^^ Apoptosis and Fas / FasL expression of SASMC were examined by immunohistochemical SABC and TUNEL assay at 1 , 3 , 5 , 7 , 15 and 30 days after modelling , and the effect of SMI and aminophylline on them were observed . ^^^ RESULTS : Fas , FasL expressions in normal SASMC were very low with a positive rate of ( 2 . 31 + / 0 . 05 ) % and ( 1 . 28 + / 0 . 47 ) % respectively . ^^^ SMI showed an inhibition on SASMC Fas and FasL expression but aminophylline did n ' t show . ^^^ CONCLUSION : Fas and FasL participated the SASMC apoptosis modulation in emphysema formation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas / FasL system is known to play a role in tissue remodeling as a result of changes in menstrual hormone levels . ^^^ The aims of this study are to examine Fas / FasL expression in endometrial hyperplasia of pre and postprogestin treatment samples and to study the Fas / FasL regulation in vitro with Ishikawa cells after progestin stimulation . ^^^ DESIGN : Pre and posttreatment paraffin embedded endometrial hyperplasia tissue samples from 26 women were examined by immunohistochemistry for changes in Fas / FasL expression related to the administration of progestins . ^^^ Fas / FasL positivity was defined by the presence of 10 % or more immunoreactive epithelial cells in each specimen . ^^^ The in vitro effects of progesterone on Fas / FasL expression and apoptosis in Ishikawa cells were examined by using Western blot and TUNEL assays , respectively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Previous studies postulated that sFas down regulates apoptosis in vitro through its blockade of the Fas L of cytotoxic cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
During development , Fas Fas ligand ( FasL ) interactions are known to play a role in apoptotic events involved in tissue remodeling and elimination of damaged cells , and macrophages are routinely observed near apoptotic cells . ^^^ Apoptosis and Fas FasL interactions are also thought to be involved in the pathogenesis of autoimmune diseases , particularly type 1 diabetes ( T1D ) . ^^^ Therefore , we used early postnatal mouse pancreata from three control strains ( C57BL / 6 , DBA / 2 , BALB / c ) and from two strains with the nonobese diabetic ( NOD ) related genetic background ( the spontaneous T1D NOD model and the lymphocyte deficient NODscid strain ) to study apoptotic phenomena together with the molecular and immunohistochemical expression of proapoptosis ( Fas , FasL ) and antiapoptosis ( Bcl 2 ) proteins . ^^^ Second , FasL ( + ) , Fas ( + ) , and Bcl 2 ( + ) structures seemed to be associated with innervation , regardless of the strain and age . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas or FasL deficient mice display an increased sensitivity to nitrobenzene induced testicular germ cell apoptosis . ^^^ SMNC3H Fas ( gld , gld ) ( gld ) mice that express a dysfunctional form of the FasL protein ( the associated ligand that activates Fas ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND AND OBJECTIVES : Normal B cells in the germinal center ( GC ) may be exposed to both tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) and Fas L . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas and FasL in human serous ovarian epithelial tumors . ^^^ The expression of Fas and FasL was studied in 86 patients with benign , borderline , and malignant serous ovarian lesions . ^^^ Expression of Fas and FasL was studied immunohistochemically and flowcytometrically . ^^^ Fas was expressed in all 90 lesions ; FasL in 57 lesions , including 2 normal ovaries . ^^^ Flow cytometry showed a range of Fas expression in short term cultures isolated from normal , borderline , and malignant ovarian serous tissue ; in the few samples studied , FasL was not expressed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas Fas L system plays a major role in the regulation of apoptosis and hence in growth in benign and malignant human tumors . ^^^ As the factors regulating cell death in benign schwannomas are not well understood , we investigated the immunoexpression of the Fas Fas L system , as well as that of the anti apoptotic factor Bcl 2 and the pro apoptotic factor Bax in 14 sporadic vestibular schwannomas , and related the findings to the MIB 1 labeling index as a marker for cell proliferation . ^^^ Whereas cytoplasmic Fas expression was seen in only one tumor ( 7 % ) , Fas L was found in the nuclei of 12 schwannomas ( 86 % ) . ^^^ Our study further showed that Fas L is present in most vestibular schwannomas ; however , due to the lack of Fas expression , apoptosis in vestibular schwannomas does not seem to be mediated via the Fas Fas L system . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Using in vitro and in vivo experimental models , we investigated Bcl 2 system and Fas / FasL channel , representing the death receptor dependent and independent pathways , respectively , in glioma cells treated with the supernatant from the activated macrophages , which was rich in tumor necrosis factor alpha and interferon gamma . ^^^ We found that levels of Fas and FasL were up regulated both in vitro and in vivo , accompanying an increase in the expression of caspase 8 . ^^^ The number of apoptotic cells was also increased significantly , although the percentage of death cells exceeded the number of tumor cells positive for Fas or FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cross talk between tumor cells and neutrophils through the Fas ( APO 1 , CD 95 ) / FasL system : human glioma cells enhance cell viability and stimulate cytokine production in neutrophils . ^^^ Accordingly , blocking the Fas / FasL interaction reduced IL 6 and IL 8 production in glioma cells and impaired their protective effect on neutrophils . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
An immunohistochemical study of proteins linked with cell death and cell survival demonstrated reduced expression of Fas , Fas L , Bcl 2 and Bax in swollen motor neurons . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Human and mouse natural mutants presenting with lymphoproliferative syndrome and autoimmunity ( ALPS ) have enlightened the role of the Fas and FasL in lymphocyte cell death and peripheral tolerance . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Western blot analysis of granulosa cells showed that the overall expressions of Fas and FasL were lower in the control group and their expressions of inhibitor of apoptosis proteins ( IAPs ) were higher than in the galactosemic group , especially at 8 h post hCG injection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression and significance of Fas and FasL protein in squamous cell carcinoma of larynx ] . ^^^ OBJECTIVE : To investigate the expression of Fas and FasL protein in squamous cell carcinoma of larynx ( LSCC ) and to evaluate its clinical significance . ^^^ METHOD : Using immunohistochemical method SABC , we studied the expression of Fas and FasL protein in 42 cases of paraffin embedded LSCC tissues and in 10 cases of normal laryngeal tissues . ^^^ The positive rates of Fas and FasL were compared with the pathological grade , clinical stage and cervical lymph node metastasis of LSCC . ^^^ RESULT : The positive rates of Fas and FasL protein staining were 47 . 6 % and 64 . 3 % in 42 cases with LSCC , while they were 90 . 0 % and 20 . 0 % in the normal laryngeal tissues ( P < 0 . 05 ) respectively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Assays for apoptosis demonstrated that anti Fas antibody CH 11 and FasL induced apoptosis only in cells that overexpress p 53 mutant 143Ala at 32 . 5 degrees C with the wild type p 53 form . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
FasL mRNA level was elevated and interaction of FasL with Fas receptor expressed in astrocytes may trigger cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We found that digested peptides from wheat gliadins ( 1 ) induce apoptosis by the CD95 / Fas apoptotic pathway , ( 2 ) induce increased Fas and FasL mRNA levels , ( 3 ) determine increased FasL release in the medium , and ( 4 ) that gliadin digest induced apoptosis can be blocked by Fas cascade blocking agents , i . e . targeted neutralizing antibodies . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We demonstrated that the process in both nonactivated and activated ( TCR cross linking ) BWRT 8 cells was not prevented by yohimbine ( a selective alpha adrenergic antagonist ) and by antibodies to Fas and Fas L . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : Samples from 47 patients ( 46 squamous cell carcinomas ( SCC ) and 1 adenosquamous carcinoma ( ASC ) ) in the first period and 30 patients ( 20 SCC , 4 ASC , and 6 adenocarcinomas ( AC ) ) in the later period were analysed for viral subtype and expression of Fas , FasL , MHC class 1 , p 53 and apoptosis . ^^^ When SCC are compared with AC / ASC , the latter have less expression of MHC class 1 , less expression of Fas , and stronger FasL expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
PRBC adhesion modulated HLEC gene expression in tumor necrosis factor alpha superfamily genes ( Fas , Fas L , and DR 6 ) and apoptosis related genes ( Bad , Bax , caspase 3 , SARP 2 , DFF45 / ICAD , IFN gamma receptor 2 , Bcl w , Bik , and iNOS ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Small cell lung cancer cell lines were resistant to FasL and TRAIL induced apoptosis , which could be explained by an absence of Fas and TRAIL R 1 mRNA expression and a deficiency of surface TRAIL R 2 protein . ^^^ Cotreatment of SCLC cells with the demethylating agent 5 ' aza 2 deoxycytidine and IFNgamma partially restored Fas , TRAIL R 1 and caspase 8 expression and increased sensitivity to FasL and TRAIL induced death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( APO 1 / CD95 ) and its ligand ( Fas L ) are cell surface proteins whose interaction activates apoptosis of Fas expressing targets . ^^^ In T cells , the Fas Fas L system regulates activation induced cell death and has been implicated in diseases in which lymphocyte homeostasis is compromised . ^^^ Moreover , several studies have described the pathogenic functions of Fas and Fas L in vivo , particularly in the induction progression of organ specific autoimmune diseases . ^^^ In this study we describe the effect of 15d PGJ ( 2 ) on the activation of the fas L gene in T lymphocytes . ^^^ We show that 15d PGJ ( 2 ) inhibits fas L mRNA expression , activation induced cell death , and fas L promoter activity by mechanisms independent of PPARgamma and mediated by its chemically reactive cyclopentenone moiety . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of Fas , FasL , TNRF 1 , and Bcl 2 was analyzed by flow cytometry and Western blotting , and activation of caspase cascade was measured using a colourimetric caspase substrate set . ^^^ Measles virus induced Fas but not FasL or TNFR 1 expression on PMBC , as well as activation of granzyme B and caspase cascade . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis of cardiomyocytes in left ventricles was verified using Western blotting based on increased expression of : the apoptosis associated death receptor Fas ( 1 . 5 fold ) ; its ligand ( FasL , 2 . 0 fold ) ; and an upstream protease caspase 8 ( 2 . 7 fold ) as well as its active cleavage peptide , p 20 ( 5 . 6 fold ) . ^^^ Haemodynamic analysis indicated that ventricular dilatation , without wall thickening , caused a 2 fold increase in LV wall stress which , together with LV end diastolic pressure , was linearly correlated with expression of Fas / FasL . ^^^ CONCLUSION : Apoptosis of cardiomyocytes in chronic HF is associated with increased wall stress , which may be responsible for the activation of a Fas / FasL and caspase 8 interaction in the region of intercalated discs . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ligation of Fas by FasL then induces a caspase cascade and apoptotic cell death . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Development of real time PCR assays for the quantification of Fas and FasL mRNA levels in lymphocytes : studies on centenarians . ^^^ During aging , there is an altered regulation of pivotal molecules that are responsible for the regulation of this type of cell death , such as those of the Fas / FasL system . ^^^ We have developed an original real time PCR assay for quantification of mRNA for Fas and FasL , and have studied a group of young donors , middle aged subjects and centenarians . ^^^ Our preliminary results suggest that during aging a subtle balance in the production of molecules that cause apoptosis could exist , and that , in order to avoid an excessive death of immune cells , a still unknown mechanism could compensate the increase of Fas with the reduction of FasL . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of the apoptosis related proteins p 53 , p 21 , Rb , bcl 2 , bax , c myc , Fas and Fas L was assessed immunohistochemically . ^^^ Untreated , both tumors were equally positive for p 53 , bax , Fas , Fas L , c myc and negative for Rb . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Disregulation of apoptosis within the vessel wall and upregulation of the Fas / Fas ligand ( Fas L ) system contribute to the development of atherosclerosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of Fas , FasL , and Bcl 2 was analyzed in all tissue samples . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Caspase 8 is an initiator caspase that becomes activated when Fas death receptor Fas ligand ( FasL ) coupling on the cell surface leads to coalescence of a `` death complex ' ' perpetuating the programmed cell death cascade . ^^^ Fas and FasL were also examined using Western blot . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Neutralizing anti Fas ( APO 1 / CD95 ) and anti Fas ligand ( FasL ) antibodies obliterated the CBDCA induced cell death . ^^^ Western blotting and reverse transcription ( RT ) PCR revealed that there were no alterations in Fas or FasL expression upon CBDCA treatment . ^^^ SCC 25 induced apoptosis of Jurkat cells , Fas sensitive T lymphatic leukemia cell line , and the apoptosis was inhibited by neutralizing anti Fas or anti FasL antibody . ^^^ These results indicate that the tongue carcinoma cells express nonfunctional Fas and functional FasL , which by themselves fail to induce apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The development of clinical activity in relapsing remitting MS is associated with a decrease of FasL mRNA and an increase of Fas mRNA in peripheral blood . ^^^ In this longitudinal study , we examined the expression of Fas , FasL , CCR 3 , CCR 5 and CXCR 3 mRNA in peripheral blood mononuclear cells ( PBMCs ) of secondary progressive ( SP ) and relapsing remitting ( RR ) multiple sclerosis ( MS ) patients . ^^^ In RR patients , FasL , CCR 3 and CCR 5 mRNA levels were increased prior to the exacerbations , but these decreased during clinical activity , while mRNA levels of Fas increased . ^^^ SP patients have increased the levels of Fas and FasL mRNA ; the latter was particularly increased during lesional activity . ^^^ Our data support the hypothesis that changes in Fas and FasL mRNA related to clinical activity are due to the migration of inflammatory cells to the central nervous system ( CNS ) . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In an in depth study of the Fas / FasL signaling pathway in thyroid tumor development , we have demonstrated that tumor cells specifically downregulate the multideath receptor adapter Fas associated death domain ( FADD ) . ^^^ Since thyrocytes also acquired FasL expression during tumor development , the absence of FADD protein could lead to greater resistance to numerous death receptor mediated apoptosis , stimulation of their own proliferation through Fas / FasL interaction , and the capacity to counter attack the infiltrating lymphocytes . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We also investigated Fas expression on T cells ( evaluated by flow cytometry ) and FasL mRNA ( evaluated by RT PCR ) , as well as Fas functionality . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Gene expression analysis using real time RT PCR additionally revealed low expression of Fas and FasL , the death receptor system activating caspase 8 and contributing to AICD . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Since chemotherapy has been shown to activate the Fas death pathway and TGCTs co express both Fas and its ligand FasL , TGCT cells might undergo apoptosis upon cisplatin treatment via autocrine or paracrine activation of the Fas system by FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The amount of p 17 caspase 3 was reduced by in vitro blockade of FasL with an FasL blocking antibody and was absent in macrophages from lpr / lpr mice , which lack functional Fas . ^^^ CONCLUSIONS : The naturally occurring Fas FasL induction of caspase 3 cleavage after macrophage attachment may represent an important physiologic mechanism that primes for cytotoxicity by oxLDL and possibly , other death inducing molecules . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , the promotion of in vivo tumor growth by Fas overexpression was reduced in gld ( FasL mutation ) mice compared to normal mice . ^^^ These data indicate that intact Fas / FasL cell signaling is required for the promotion of in vivo tumor growth by Fas overexpression in 3LL cells . ^^^ In contrast to the efficient Fas mediated killing induced in vitro by crosslinking with anti Fas antibody , Fas overexpressing 3LL cells were resistant in vitro to Fas mediated apoptosis by activated T cells or transient FasL transfection . ^^^ These data suggest that agonist anti Fas antibody and natural FasL can transmit qualitatively different signals , and crosslinking of Fas with natural FasL on 3LL cells does not deliver the expected death signal . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We conclude that treatment with low doses of resveratrol , such as those found after moderate wine intake , is not sufficient to stop human leukemia cell line proliferation and that cell resistance , marked by high FAS L ( CD 95 L ) expression , could be mediated by low ( delta psi ) mitochondria released antiapoptotic factors such as BCL 2 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We conclude that ATG induced apoptosis in T cells involves both Fas and TNF pathways and TNF alpha is produced much earlier than Fas and FasL expression . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Reverse transcriptase polymerase chain reaction ( RT PCR ) and flow cytometry were used to assess the expression of FasL and Fas mRNA and protein . ^^^ The lethal cytokines FasL and TRAIL were expressed by peritoneal effluent cells , while cultured mesothelial cells expressed FasL , Fas , and TRAIL receptors . ^^^ IFNgamma increased the cell surface expression of Fas and the sensitivity of mesothelial cells to FasL induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Spontaneous mutations in FasL and its cognate receptor Fas ( CD 95 ) have helped understand the role of these molecules in the disease . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We studied the expression of Fas / FasL on CD34+ cells in low risk MDS and its change after AMF treatment . ^^^ Before treatment , responding patients presented a significantly lower expression of Fas ( median 53 % ) and FasL ( median 26 % ) than non responders ( 85 % and 70 % , respectively ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this study , we have investigated the role of Fas / Fas ligand ( FasL ) mediated apoptosis in the pathogenesis of CH . ^^^ Moreover , the expressions of mRNAs for T helper ( Th 2 ) cytokine ( interleukin ( IL ) 4 ) , Th 1 cytokine ( interferon ( IFN ) gamma ) and proapoptotic molecules ( Bax , Fas , FasL and IL 1beta converting enzyme ( ICE ) / caspase 1 ) were significantly elevated in the oxazolone sensitized mouse skin 6 72 h after allergen challenge . ^^^ Our results thus suggest that Fas / FasL pathway partially contributes to apoptosis in murine CH and that Fas / FasL mediated apoptosis plays a partial role in the development of CH . ^^^ The contribution of Fas / FasL mediated apoptosis to CH appears independent of Th 1 and Th 2 cytokines . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Whole prostates 1 10 days after castration did not show a significant change in mRNA levels encoding either Fas or FasL , which some studies suggest are necessary for regression to occur . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Platelet accumulation also coincided with the expression of Fas and FasL in the diabetic retina . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas , FasL and Bcl 2 and apoptosis of bone marrow CD34+ cells in patients with myelodysplastic syndrome ] . ^^^ In order to observe the expression of Fas , FasL and Bcl 2 and apoptosis of bone marrow CD 34 ( + ) cells in patients with myelodysplastic syndrome ( MDS ) , and to explore the relation between the expression of these antigens and apoptosis , the expression of Fas , FasL and Bcl 2 and apoptosis of bone marrow CD 34 ( + ) cell were evaluated by flow cytometry in 26 patients with MDS including 9 cases of refactory anemia ( RA ) , 1 case of RA with ringed sideroblasts ( RAS ) , 9 cases of RA with excess blasts ( RAEB ) and 7 cases of RAEB in transformation ( RAEB t ) , 10 patients with acute myeloid leukemia ( AML ) and 6 control patients with normal bone marrow . ^^^ The results showed that the expression of Fas and FasL of CD 34 ( + ) cells significantly increased in all types of MDS patients compared with control group ( P < 0 . 01 ) . ^^^ There was no correlation between the expression of Fas or FasL and apoptosis on CD 34 ( + ) cell of MDS patients . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Germ cell apoptosis in autoimmune orchitis : involvement of the Fas FasL system . ^^^ PROBLEM : The aim of this study was to determine the mechanism of germ cell death in experimental autoimmune orchitis ( EAO ) and the involvement of the Fas FasL system in this process . ^^^ Fas , FasL and caspase 3 expression was detected by immunohistochemistry . ^^^ Immunohistochemical data suggest that the Fas FasL system mediates germ cell apoptosis in an autocrine and / or paracrine way . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To analyze whether T cell apoptosis requires the Fas / Fas ligand ( FasL ) pathway , MLRs were performed with Fas , FasL deficient , and wild type DC and T cells . ^^^ No differences were found on comparison of wild type DC with Fas / FasL deficient DC or T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , sodium salicylate did not exert any significant effects on the expression of Fas L that is implicated in extrinsic apoptotic pathway and the levels of Bcl 2 family proteins , Bcl 2 , Bcl xsl , and Bad , which are involved in intrinsic apoptotic pathway , and anti apoptotic molecules , c IAP 1 and HSP 73 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Assignment of swine TNFRSF 6 ( Fas ) to chromosome 14q25 > q 27 and TNFSF 6 ( FasL ) to chromosome 9q14 > q 22 by FISH and radiation hybrid mapping . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
They constitutively express the death receptor Fas and its ligand , FasL but do not undergo apoptosis . ^^^ Upon elimination of the parasite from the host cell by treatment with a theilericidal drug , cells become increasingly sensitive to Fas / FasL induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , higher expression levels of 12 apoptosis related genes ( caspase 3 , 6 , 7 , 8 , 9 , 10 , 12 , BAD , BAX , BID , Fas , and FasL ) were shown in chorionic villi from RPL patients than those from normal controls . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Carvedilol attenuates CPB induced apoptosis in dog heart : regulationof Fas / FasL and caspase 3 pathway . ^^^ OBJECTIVE : To evaluate the effects of Carvedilol on cardiopulmonary bypass ( CPB ) induced myocardiocyte apoptosis and its effects on regulation of Fas , FasL expression , caspase 3 activity and oxidative stress in the left ventricle ( LV ) in this setting . ^^^ The expressions of Fas and FasL were detected immunohistochemically and quantified by fluorescence activated cell sorting ( FACS ) . ^^^ The expressions of Fas and FasL were significantly downregulated by Carvedilol ( P < 0 . 001 and 0 . 003 , respectively ) . ^^^ CONCLUSIONS : Carvedilol significantly reduces CPB induced cardiomyocyte apoptosis in dog hearts and the reduction of cardiomyocyte apoptosis is associated with downregulation of Fas and FasL expression , inhibition of caspase 3 activity and oxidative stress in LV . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To elucidate molecular events in the apoptosis , protein expressions of Bcl 2 , Bax , Fas , and FasL were measured by Western blotting using specific antibodies in HL 60 cells . ^^^ The level of Bcl 2 remained largely unchanged , but the Bax , Fas , and FasL expression showed up regulation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
ECP treated lymphocytes of chronic graft versus host disease patients undergo apoptosis which involves both the Fas / FasL system and the Bcl 2 protein family . ^^^ Immediately after isolation , there was no difference in Bcl 2 or bax expression among the four different samples , or in Fas and FasL mRNA . ^^^ In conclusion , in patients affected by cGVHD , ECP induced apoptosis of lymphocytes with the involvement of both the Fas / FasL system and the Bcl 2 protein family . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression and function of apoptosis related genes Bcl 2 / Bax and Fas / Fas L in the course of stress ulcer ] . ^^^ OBJECTIVE : To investigate the correlation between the expressions of apoptosis promoting gene Bax , apotosis inhibiting gene Bcl 2 , and Fas / FasL in gastric mucosa in the course of stress ulcer . ^^^ In situ hybridization was used to detect the mRNA expression of Bcl 2 , Fas , and FasL . ^^^ Since 8 12 hours after the termination of WRS the number of apoptosis began to decrease , however , still remained at a level significantly higher than the normal level ( P < 0 . 05 ) . ( 2 ) Fas mRNA and FasL mRNA were not expressed in the controls . ^^^ The expression of Fas / FasL has no effect on the gastric mucosa apoptosis related to WRS . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
While Fas and FasL are involved in apoptosis of bystander cells , mitochondrial pathway is required for apoptosis of infected cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas , a member of the tumor necrosis factor receptor superfamily , is a transmembrane protein whose extracellular domain binds its cognate ligand ( FasL ) , which can induce apoptosis in sensitive cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CC531s colon carcinoma cells induce apoptosis in rat hepatic endothelial cells by the Fas / FasL mediated pathway . ^^^ Metastasizing colon carcinoma cells express more FasL than primary colon carcinoma cells and cancer cells induce apoptosis in hepatocytes by the Fas / FasL pathway . ^^^ Therefore , this study focused on Fas / FasL expression and functionality in rat liver sinusoidal endothelial cells ( LSECs ) and CC531s colon carcinoma cells in vitro and in vivo . ^^^ RT PCR and immunochemistry revealed Fas and FasL in LSECs and CC531s , respectively . ^^^ Functionality of Fas was assessed in vitro by incubation with human recombinant FasL ( 1 100 ng / ml ) with or without enhancer . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Role of Fas , FasL in NOD insulitis ] . ^^^ OBJECTIVE : To analyze the significance of Fas FasL in NOD insulitis and to explore the mechanism of the autoimmune diabetes . ^^^ The pathological data were obtained from the HE staining of the pancreatic sections and the immunohistochemical staining , in which insulin , Fas , FasL , CD 8 were detected . ^^^ Furthermore , there was certain correlation between the expression of some antigens : in islet cells , between Fas and insulin ( negative , P < 0 . 01 ) , insulin and FasL ( negative , P < 0 . 01 ) , and Fas and FasL ( positive , P < 0 . 01 ) . ^^^ CONCLUSION : To sum up , there may be some important and complicated effects by Fas FasL on the damage of beta cells and the regulation of autoreactive T cells in NOD insulitis , which will facilitate further studies in human type 1 diabetes . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas , FasL , and NF kappa B in the process of osteoclast like cell apoptosis effected by sodium fluoride ] . ^^^ OBJECTIVE : To detect the changes in the expression of apoptosis signals : Fas , FasL and NF kappa B in the process of osteoclast like cell ( OLC ) apoptosis effected by sodium fluoride . ^^^ METHODS : After co culture of osteoclast like cells with 0 , 5 , 10 and 15 mg / L sodium fluoride , Fas , FasL and NF kappa B antibody expressions were detected by immune histochemistry . ^^^ RESULTS : The expression of Fas and FasL increased with the concentration of the sodium fluoride , however the expression of NF kappa B decreased with the concentration of sodium fluoride . ^^^ CONCLUSION : In the process of OLC apoptosis induced by sodium fluoride , the expression of Fas and FasL increased , and that of NF kappa B decreased with the concentration of sodium fluoride respectively , and the changes of the expression present a dose dependent pattern . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The percent age of apoptotic cells and positive expressions of p 53 , bax and bcl 2 , fas , fasL proteins were determined by FCM . ^^^ NADH could not only eliminate the apoptosis induced by 10 ray irradiation , but also up regulate expression of bcl 2 protein and down regulate expression of p 53 , bax , fas and fasL proteins ( P < 0 . 05 ) . ^^^ CONCLUSION : NADH has marked anti radiation effect , its mechanism may be associated with up regulation of bcl 2 expression and down regulation of p 53 , bax fas and fasL expression , as well as decline of intracellular ROS . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
An RNase protection assay showed , in the rebamipide administered group , significantly decreased mRNA levels of apoptosis related genes such as caspase 8 , FasL , Fas , TRAIL and various cytokines genes such as IFN gamma , RANTES , TNF alpha , TNFR p 75 , IL 1beta . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas Fas ligand ( FasL ) system is one of the apoptotic signaling pathways , shown to be important in the development of local immune tolerance during and after implantation . ^^^ Moreover , hCG stimulates FasL mRNA and protein expression without affecting Fas mRNA in these cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We have evaluated the involvement of the Fas Fas ligand ( FasL ) pathway in rapid UVA induced apoptosis in human leukemia HL 60 cells . ^^^ These data support a mechanism for rapid , UVA induced apoptosis in HL 60 cells involving initial formation of the Fas FADD caspase 8 death complex in an FasL independent manner . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Mice given an adequate parenteral dose of agonistic anti Fas antibody ( aFas ) or of FasL are known to develop a devastating liver injury and to die in a few hours . ^^^ Neither the overall tissue levels of Fas and FasL nor Fas expression at the hepatocyte surface are altered in the liver of R ( ) animals . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Signaling through the Fas / Fas ligand ( FasL ) pathway plays a central role in immune cell response and function ; however , under certain pathological conditions such as sepsis , it may contribute to the animal ' s or patient ' s morbidity and mortality . ^^^ To determine the contribution of FasL to mortality , we conducted survival studies by blocking Fas / FasL with Fas receptor fusion protein ( FasFP ) in vivo . ^^^ These data indicate that in vivo inhibition of Fas / FasL signaling has tissue specific effects on the induction of macrophage apoptosis , functional changes , and liver damage , which may contribute to the host ' s ability to ward off a septic challenge . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We also investigated crucial steps in the apoptotic process , including Fas / Fas ligand ( FasL ) phenotype , intracellular expression of the interleukin 1beta converting enzyme ( ICE ) p 20 , mitochondrial membrane potential ( DeltaPsim ) , generation of mitochondrial reactive oxygen species , and glutathione ( GSH ) levels . ^^^ RESULTS : Expression of Fas , FasL and ICEp 20 was six fold , four fold , and five fold increased , respectively , among pancuronium treated lymphocytes with respect to control cultures ( P = 0 . 0001 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In chronic inflammation ( SAT ) , Fas , FasL , and FLIP were upregulated and predominant in inflammatory cells . ^^^ Upregulation of FLIP by inflammatory cells may block Fas mediated apoptosis , contributing to chronic inflammation , whereas increased FLIP expression by thyrocytes in resolving G EAT may protect thyrocytes from apoptosis , and FasL expression by thyrocytes may induce apoptosis of inflammatory cells , contributing to resolution . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The relationship of Fas and Fas L protein expression in oral carcinogenesis ] . ^^^ OBJECTIVE : The purpose of the study is to investigate the mechanism of immune escape and the expression of Fas and Fas L in oral premalignant lesions ( OPLs ) and oral squamous cell carcinomas ( OSCCs ) . ^^^ The expression of Fas and Fas L was evaluated semi quantitatively as follows : , no expression ; + ( mild ) , < 5 % positive cells ; ++ ( moderate ) , 6 % 25 % positive cells ; +++ ( intense ) , 26 % 50 % positive cells ; or ++++ ( very intense ) , > 50 % positive cells . ^^^ Fas L expression was discovered in each stage of the process of oral carcinogenesis . ^^^ In hyperkeratotic tissues and OPLs , the number of Fas L expression cells was significantly higher than that in the normal controls . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( CD 95 ) and its ligand FasL signal apoptosis and are involved in tissue homeostasis and the elimination of target cells by cytotoxic T cells . ^^^ Frequent loss of Fas expression and function in human lung tumours with overexpression of FasL in small cell lung carcinoma . ^^^ Fas ( CD 95 ) and its ligand FasL signal apoptosis and are involved in tissue homeostasis and the elimination of target cells by cytotoxic T cells . ^^^ Corruption of this signalling pathway in tumour cells , for example by reduced Fas expression or increased FasL expression , can participate in tumour development and immune escape . ^^^ The present study has analysed Fas / FasL expression and Fas death signalling function in vivo in lung tumour tissues [ 57 non small cell lung carcinomas and 64 neuroendocrine lung tumours including small cell lung carcinoma ( SCLC ) ] in comparison with normal lung tissue , and in vitro in neuroendocrine tumour cell lines in comparison with normal human bronchial epithelial cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The role of Fas / FasL system in the regulation of tumor immune system interactions in papillary thyroid carcinoma in children and adolescents ] . ^^^ Fas ( APO 1 / CD95 ) is a transmembrane protein that induces apoptosis in susceptible normal and neoplastic cells upon cross linking by its ligand ( FasL ) . ^^^ Changes in the Fas and FasL expression were suggested to be a potential mechanism of tumor immune evasion . ^^^ The presence of Fas and FasL in thyroid tissue specimens was examined immunohistochemically . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In a previous study , we documented that Fas and FasL are coexpressed in choriocarcinoma [ Gynecol . ^^^ This study was conducted to examine the role of the Fas / FasL pathway in immune privilege of BeWo and NJG choriocarcinoma cells in culture . ^^^ Coculture experiments with Fas sensitive Jurkat cells were used to demonstrate functional FasL from choriocarcinoma . ^^^ In coculture experiments , FasL from choriocarcinoma cells induced apoptosis in the Fas sensitive Jurkat cells , thereby indicating the capacity to evade immune attack . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Glioma associated IL 10 induction was suppressed by interrupting the engagement of Fas and its ligand ( Fas L ) with the antagonistic Ab , ZB 4 , by reducing Fas L expression of glioma cells using the Fas L specific ribozyme , or by preventing cell to cell contact in a Transwell culture setting . ^^^ In summary , our results demonstrate nonlethal cross talk between tumor and immune cells leading to IL 10 dysregulation in T cells , which might contribute to Fas L ( + ) tumor associated immunosuppression . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The exposure of HOSE or OVCA cells to an activating anti Fas antibody induced cell loss , whereas treatment of cells with a blocking anti FasL antibody reduced the P 4 induced cell loss . ^^^ These results reveal for the first time that P 4 induces apoptosis in HOSE and OVCA cells via activation of a caspase 8 initiated Fas / FasL signaling pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We identified 12 novel nucleotide substitution variants and one deletion variant in 17 genes analyzed ( TGFBETA ; R , BETA ; 2M , IFNGAMMA ; , TNFALPHA ; , TNFALPHA ; R , LTALPHA ; , IL 6 , IL 12 , IL 2 , IL 1ALPHA ; , IL 1BETA ; , IL 1RN , IL 10 , CTLA 4 , CD40L , FAS and FASL ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression patterns of pro apoptotic genes ( Fas , FasL , TRADD , FADD ) and caspases 2 , 3 , 8 , 9 were studied using PCR . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas , FasL and caspase 3 in the cells without and with resveratrol treatments was examined by immunocytochemical staining and mRNA in situ hybridization and the influence of anti Fas antibody ( 200 ng / ml ) in cell growth and survival was determined as well . ^^^ Fas was constitutively expressed but FasL was undetectable in the four lines in spite of resveratrol treatment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These T cells express Fas , FasL , negligible levels of Bcl 2 proteins and undergo activation induced cell death as determined by TUNEL assay leading to resolution of the inflammatory response . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of CD 95 ligand ( FasL ) was more than doubled in TKO animals after FB 1 whereas it was unaltered in the WT group . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Injection of FasL ( + ) LSA tumor cells into syngeneic C57BL / 6 wild type mice but not C57BL / 6 lpr / lpr ( Fas deficient ) mice caused apoptosis in splenocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Renal tubular epithelial cell apoptosis by Fas FasL dependent self injury can augment renal allograft injury . ^^^ The role of Fas FasL interactions in kidney allograft injury may be complex as renal tubular epithelial cells ( TEC ) express both Fas and FasL . ^^^ In co cultures of TEC , FasL bearing , Fas null TEC was demonstrated to induce apoptosis of TEC bearing Fas . ^^^ Expression of kidney Fas FasL on injury was tested in a renal transplant model . ^^^ C57BL / 6 ( B 6 ) mice were transplanted with Fas deficient C3H lpr / lpr or FasL mutation C3H gld / gld kidneys as compared to normal ( wild type [ WT ] ) C3H / Hej donors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We have previously shown that Fas ligation induces expression of chemokines such as interleukin 8 by human astrogliomas , which may partially explain the in vivo angiogenic property of FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of the FasR is postulated to lead to apoptosis via CD 95 receptor CD 95 ligand ( FasL ) interaction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of membrane bound and soluble FasL in Fas and FADD dependent T lymphocyte apoptosis induced by mildly oxidized LDL . ^^^ We now show that this is preceded by an increase of Fas and FasL expression . ^^^ Fas and FasL overexpression was dependent on reactive oxygen species ( ROS ) production as well as ERK and JNK activation . ^^^ Altogether , our results highlight the putative role of both membrane bound and soluble FasL in oxLDL induced Fas and FADD dependent apoptosis of T lymphocytes and suggest an involvement of ROS , ERK , and JNK in this process . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / FasL expression in tumor biopsies : a prognostic response factor to fluoropyrimidines . ^^^ Various studies suggested that cytotoxicity induced by 5 fluorouracil ( 5 FU ) is an apoptotic mechanism possibly mediated by the Fas / FasL system . ^^^ In this preliminary work , we studied retrospectively the role the Fas / FasL expression as a predictive response factor with fluoropyrimidine based chemotherapies . ^^^ We developed a real time PCR method for measuring Fas and FasL expression in various biopsies from patients treated with a FUFOL like protocol . ^^^ No correlation was found between Fas or FasL expression and overall survival or partial response . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the effect of Shen Mai injection ( SMI ) and aminophylline on diaphragmatic muscle cell apoptosis and the Fas / FasL expression in chronic hypoxic rats . ^^^ Apoptosis and Fas / FasL expression of diaphragmatic muscle cells were examined by the streptavidin biotin peroxidase complex ( SABC ) immunohistochemistry techniques and terminal deoxynucleotidyl transferase mediated dUTP biotin nick end labeling ( TUNEL ) assay , and Dunnett t test was employed to compare the effects of SMI and aminophylline . ^^^ RESULTS : ( 1 ) Fas , FasL expression in normal diaphragmatic muscle cells was very low with a positive rate of ( 2 . 77 + / 0 . 45 ) % and ( 2 . 32 + / 0 . 61 ) % . ^^^ CONCLUSIONS : Fas and FasL participated in diaphragmatic muscle cell apoptosis in rats with chronic hypoxia . ^^^ SMI showed a definite effect on the Fas and FasL protein expression and decreased diaphragmatic muscle cell apoptosis , which contributed to the therapeutic effect on diaphragmatic fatigue caused by hypoxia . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Co localized expression of FasL , Fas , Caspase 3 and apoptotic DNA fragmentation in mouse testis after oral exposure to di ( 2 ethylhexyl ) phthalate . ^^^ Expression of apoptosis related proteins FasL , Fas and Caspase 3 , as well as DNA fragmentation were examined in mouse testis 12 h after exposure to 4 0 . 004 mg / g di ( 2 ethylhexyl ) phthalate ( DEHP ) . ^^^ Immunocytochemical examination of the highest dose ( 4 mg / g DEHP ) mouse revealed a distribution of FasL in Sertoli cell and Fas in nearby spermatocyte , and Fas and Caspase 3 in the same spermatocyte . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , Fas had no role in CsA induced apoptosis , as CsA did not sensitize to FasL induced apoptosis , caspase 8 activity was not increased , and neither blocking anti FasL antibodies nor caspase 8 inhibition prevented CsA induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In murine models of autoimmune lupus , mutations in cell death receptor Fas ( CD 95 ) and its ligand , FasL ( CD 95 L ) , have been identified . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Overexpression of HBxAg in hepatocellular carcinoma and its relationship with Fas / FasL system . ^^^ AIM : To study the expression and serum level of HBxAg , Fas and FasL in tissues of HCC patients , and to assess the relationship between HBxAg and Fas / FasL system . ^^^ METHODS : Tissues from 50 patients with HCC were tested for the expression of HBxAg , Fas and FasL by S P immunohistochemistry . ^^^ RESULTS : The expression of HBxAg , Fas and FasL in carcinoma tissues was 96 % , 84 % and 98 % , respectively . ^^^ Staining of HBxAg , Fas and FasL was observed predominately in cytoplasms , no significant difference was found in intensity between HBxAg , Fas and FasL ( P > 0 . 05 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Autoimmune diabetes in the NOD mouse : an essential role of Fas FasL signaling in beta cell apoptosis . ^^^ Despite evidence that both Fas and FasL can be expressed in pancreatic islets , there has been considerable controversy regarding the potential role of Fas signaling in autoimmune beta cell death . ^^^ Using the HIPFasL model , we have been able to demonstrate that , in the presence of an inflammatory infiltrate , FasL expressing beta cells are exquisitely sensitive to Fas mediated apoptosis and that this can be blocked by preventing FasL Fas interaction . ^^^ This points to a highly important role of Fas FasL interaction in autoimmune beta cell death . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
IEL proved to be CD45RO , CD 3 , CD 7 , CD 8 , and Tia 1 positive , while CD 4 , CD 20 , CD79a , CD 56 , CD 57 , granzyme B , perforin , TCR gamma delta , TCR beta ( 5 19 ) , CD 95 ( FAS ) , CD 95 L ( FAS L ) and HLA 2 were negative . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , the results showed that hop bitter acids promoted the up regulation of Fas and FasL prior to the processing and activation of pro caspase 8 and cleavage of Bid , suggesting the involvement of a Fas mediated pathway in hop bitter acids induced cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Suction blisters from unirradiated and irradiated skin were raised , and Fas , FasL , and apoptosis of epidermal cells quantified by flow cytometry . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Release of cytochrome c from mitochondria into the cytosol was distinct 9 h after irradiation , while the levels of most apoptosis related molecules such as Fas , FasL , Bcl 2 , Bax and p 53 were unchanged . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Upregulation of Fas and FasL expression in testosterone induced apoptosis of macrophages . ^^^ In this report , we studied the effect of testosterone on the apoptosis of bone marrow derived macrophages ( BMMs ) and the function of the Fas / Fas ligand ( FasL ) system in the process . ^^^ Testosterone induced apoptosis was associated with the enhanced expression of Fas , FasL , and caspase 8 . ^^^ These data suggest that the Fas / FasL system may play an important role in the testosterone induced apoptosis of macrophages . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Because binding of FasL to its receptor Fas could play an important role in tubulitis and in the death of graft tubular epithelial cells during kidney allograft rejection , a gene polymorphism recently identified in position 671 in the promoter of the TNFRSF 6 gene coding for Fas was investigated in donors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas FasL system has been known as a prototypic inducer of extrinsic cell death responsible for cell mediated cytotoxicity , peripheral immune regulation , immune privilege and `` counterattack ' ' of malignant tumor cells against the host immune system . ^^^ Fas and FasL are expressed in the normal CNS , and expression increases in inflamed and degenerated brains . ^^^ Like other specialized tissues such as the eye and testis , the Fas FasL system is thought to be involved in immune suppressed status in the CNS . ^^^ Expression of Fas and FasL is significantly elevated in a variety of the neurologic disorders , suggesting the possibility that this system may play roles in degenerative and inflammatory responses in the CNS . ^^^ Therefore , the FasL Fas system should be considered as a double edged sword in the CNS : maintaining the immune suppressed status in normal brain and inducing neuronal cell death and inflammation in a variety of neurologic disorders . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Caspase 8 , caspase 9 , FLIP , Fas , FasL , and TNFalpha protein expression was assessed further using Western blot analysis and ELISA . ^^^ FLIP and Fas gene and protein expression were not significantly altered in hypoxic cells compared to normoxic controls . mRNA and protein levels of TNFalpha and TNFR 1 were significantly decreased , while FasL mRNA and proteins levels were significantly increased in hypoxic HCEC . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Perforin / granzyme B and Fas / FasL mediated killing pathways are the main effector mechanisms of CTL and NK cells in antitumor immune responses . ^^^ Utilizing perforin knockout mice ( B 6 PKO ) and Fas and FasL mutant ( B 6 MRL and B 6 Smn ) mice , we found that perforin expression in the host plays a crucial function in the prevention of metastasis . ^^^ However , local tumor rejection of an H 2K ( b ) and B 7 1 transfectant , 39 . 5 B 7 cells , was not dependent either on perforin or Fas / FasL expression in vivo . ^^^ In addition , CTL lysis of 39 . 5 B 7 cells was independent of perforin and Fas / FasL interactions in 18 hour in vitro assays . ^^^ Thus , these results suggested that perforin , Fas / FasL , gammaIFN and TNF alpha independent lytic mechanisms , mediated by CD 8 T cells , have a crucial role in rejection of 39 . 5 B 7 cells in vivo . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In additional studies , using the gld ( generalized lymphoproliferation disease ) and lprcg ( lymphoproliferation complementing gld ) mice , which harbor loss of function mutations in Fas L and Fas , respectively , we have shown that heat induced germ cell apoptosis is not blocked , thus providing evidence that the Fas signaling system is not required for heat induced germ cell apoptosis in the testis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
T cell receptor ( TCR ) stimuli trigger FasL synthesis but also sensitize activated T cells to Fas mediated apoptosis through an unknown mechanism . ^^^ Here we show that TCR restimulation of activated human CD 4 ( + ) T cells resulted in Fas translocation into lipid raft microdomains before binding FasL , rendering these cells sensitive to apoptosis after stimulation with bivalent antibody or FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Among these costimulatory molecules , strong expression of 4 1BBL and Fas was induced in the aortic tissue , and most of the infiltrating cells expressed 4 1BB and FasL , suggesting these pathways play critical roles in T cell mediated vascular injury . ^^^ Our findings strongly suggest that 4 1BB / 4 1BBL and Fas / FasL pathways play important roles in vascular injury in Takayasu ' s arteritis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The percent of apoptotic markers ( Fas , FasL and Bcl 2 ) on lymphocytes and CD 34 positive cells did not change after DLI throughout the different study periods . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Upregulation of caspase 3 activity as well as Bax , Fas , FasL , and DFF expression ( p < 0 . 05 ) indicated simultaneous induction of apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A / J mice challenged with B . anthracis ( Sterne ) showed increased gene expression for Fas , FasL , Bax , IL 1 beta , TNF alpha , TGF beta , MIP 1alpha , KC and RANTES . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of survivin in ovarian epithelial carcinoma and its correlation with expression of Fas and FasL ] . ^^^ This study was designed to examine the expression of survivin and its correlation with expression of Fas and FasL in ovarian epithelial carcinoma . ^^^ METHODS : Immunohistochemical assay ( SP method ) was used to detect the expression of survivin , Fas and FasL genes in 84 ovarian cancer tissues , 39 benign tumors of ovary , and 20 normal ovary tissues . ^^^ Positive survivin expression was strongly correlated with Fas and FasL expression . ^^^ CONCLUSION : ( 1 ) High expression of survivin may plays an important role in the development of ovarian cancer and could be a useful prognostic maker for patients with ovarian cancer . ( 2 ) The abnormal expression of Fas and FasL in ovary cancer and their correlation with survivin suggested that survivin might be in cooperation with Fas and FasL , which involved in the pathogenesis of ovarian cancer . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The role of Fas / FasL system in induction of hepatocyte apoptosis in chronic viral hepatitides ] . ^^^ The aim of the study was assessment of hepatocyte apoptosis depending on expression of Fas and FasL proteins by various liver cells in patients with chronic viral hepatitis B ( CVHB ) or chronic viral hepatitis C ( CVHC ) . ^^^ Thus , a great part of hepatocytes in CVH are killed by the virus ; Fas / FasL interaction is leading in damage to hepatocytes in CVH . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
For example , TNFalpha activates TNF R 1 while FasL and TL1A activate Fas and DR 3 respectively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression and clinical significance of Fas FasL of pleomorphic adenoma and adenoid cystic carcinoma in parotid gland ] . ^^^ OBJECTIVE : To determine the expression and clinical significance of Fas and FasL in cases of occurrence and development of pleomorphic adenoma and adenoid cystic carcinoma ( ACC ) in parotid gland . ^^^ METHODS : Using Immunohistochemistry techniques and quantitative analysis under computerized system , we investigated Fas FasL expression in 21 cases of normal parotid gland , 35 cases of pleomorphic adenoma in parotid gland and 32 cases of ACC in parotid gland . ^^^ RESULTS : All cases of ACC of parotid gland showed Fas and FasL negative expression , no correlation was found between the expression of Fas FasL and the histological type and the pathological grades of ACC . ^^^ Although both normal parotid gland and pleomorphic adenoma of parotid gland had distinct expression of Fas and FasL , the positive expression of Fas FasL in pleomorphic adenoma of parotid gland cases were both significantly lowered ( P < 0 . 01 ) than that in normal parotid gland . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In the animal model , FasL appeared to be less toxic for the liver compared with anti Fas antibodies when administered intraperitoneally . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , mutations in the genes encoding Fas and its ligand ( FasL ) are rare in classical SLE . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
AIM : To investigate the effect of acupuncture and moxibustion on epithelial cell apoptosis and expression of Bcl 2 , Bax , fas and FasL proteins in rat ulcerative colitis . ^^^ Epithelial cell apoptosis and expression of Bcl 2 , Bax , fas and FasL proteins were detected by TUNEL and immunohistochemical method respectively . ^^^ The expression of Bcl 2 , Bax , fas and FasL in colonic epithelial cells in MC was higher than that in NC , and was markedly down regulated by herbs partition moxibustion or electro acupuncture treatment . ^^^ Acupuncture and moxibustion can regulate the expression of Bcl 2 , Bax , fas and FasL proteins and inhibit the apoptosis of epithelial cells of ulcerative colitis in rats by Bcl 2 / Bax , fas / FasL pathways . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The present study sought to investigate whether Fas / FasL induced tubular epithelial cell apoptosis was a feature of experimental diabetic nephropathy . ^^^ These changes were associated with an increase in both Fas mRNA and Fas L ( ligand ) within the tubules ( P < 0 . 01 ) . ^^^ Treatment of diabetic Ren 2 rats with perindopril ( 6 mg / kg per day ) reduced the apoptosis to control levels and was associated with a reduction in Fas mRNA and Fas L protein ( P < 0 . 05 ) . ^^^ CONCLUSION : In conclusion , Fas / Fas L induced tubular apoptosis is a feature of diabetic Ren 2 rats and is attenuated by the blockade of the RAS . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Thymic atrophy via estrogen induced apoptosis is related to Fas / FasL pathway . ^^^ However , it is unclear whether or not estrogen induces thymic involution by triggering apoptosis depended on Fas FasL interactions . ^^^ A semi quantitative reverse transcriptase polymerase chain reaction ( RT PCR ) method was used to analyze Fas and FasL mRNA levels . ^^^ The results showed that E ( 2 ) induced thymic atrophy , increased the rates of apoptotic death , and enhanced the Fas / FasL mRNA levels . ^^^ These findings suggested that Fas / FasL mediated apoptosis involved in the induction of thymic atrophy by E ( 2 ) . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immuno localization of Fas and FasL in rat hepatic endothelial cells : influence of different fixation protocols . ^^^ In this short report , we describe with the aid of confocal laser scanning microscopy the immunolocalization of Fas and FasL on liver sinusoidal endothelial cells , and show how the localization of these two molecules differ when the cells are fixed with different fixation protocols . ^^^ Methanol fixation shows diffuse staining of Fas and FasL in the cytoplasm , as well as in the nucleus . ^^^ In contrast , paraformaldehyde fixation reveals the presence of Fas and FasL polarized at one side of the cell and only in the cytoplasm . ^^^ In conclusion , paraformaldehyde preserves the ( nuclear ) membrane associated structures better then methanol and results in a more accurate localization of Fas and FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We show that PV IgG and an antibody against Fas receptor ( anti FasR ) induce lesions in vitro in a similar way , causing : ( 1 ) secretion of soluble FasL ; ( 2 ) elevated cellular amounts of FasR , FasL ( soluble and membranal ) , Bax and p 53 proteins ; ( 3 ) reduction in levels of cellular Bcl 2 ; ( 4 ) enrichment in caspase 8 , and activation of caspases 1 and 3 ; ( 5 ) co aggregation of FasL and FasR with caspase 8 in membranal death inducing signaling complex ( DISC ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here , we show that the genetic and antibody mediated inactivation of CD 152 ( cytotoxic T lymphocyte antigen 4 ) in T helper ( Th ) effector cells reduced the frequency of nonapoptotic cells in a completely Fas / Fas ligand ( FasL ) dependent manner . ^^^ CD 152 cross linking together with stimulation of CD 3 and CD 28 on activated Th 2 cells prevented activation induced cell death ( AICD ) as a result of reduced Fas and FasL expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To determine whether the Fas / Fas ligand ( FasL ) ( CD95 / CD178 ) system contributes to the development of an inflammatory response in vivo , 2 . 5 microg of bacterial lipopolysaccharide ( LPS ; endotoxin ) per g was administered intranasally to healthy mice ( C57BL / 6 ) and mutant mice deficient in either Fas ( lpr mice ) or FasL ( gld mice ) . ^^^ These observations provide further evidence of a proinflammatory role for the Fas / FasL system in the lungs . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The effects of Fas ligand ( FasL ) expression by tumor cells on their tumorigenicity and immunogenicity have been reported as opposite , contradictory results . ^^^ In some systems the killing of Fas positive cytotoxic T cells ( CTL ) by FasL expressing tumors resulted in increased tumorigenicity while in other systems tumors expressing FasL were eliminated by neutrophil mediated inflammation . ^^^ Despite the fact that FasL expressing cells kill effectively appropriate target cells ( L 1210 fas ) compared to parental cells ( D 122 ) and low expressors ( DFasL 33 ) , these tumor cells were completely rejected in syngeneic mice ( C57BL / 6 ) , but not in Fas mutant B 6 MRL mice , suggesting that functional Fas receptor expression in the host was required to induce an anti tumor mechanism . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , the antagonistic anti Fas DX 2 and ZB 4 monoclonal antibodies ( mAbs ) , which block the induction of Cyt c release and caspase 2 , 8 , and 9 activities by the agonistic anti Fas CH 11 mAb , and the neutralizing anti Fas ligand ( FasL ) NOK 1 mAb all fail to inhibit AQ 9 induced Cyt c release and caspase 2 , 8 , and 9 activities , suggesting that the FasL / Fas signaling pathway is not involved in the mechanism by which antiproliferative AQ analogs trigger apoptosis in HL 60 cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis was determined immunohistochemically using antibodies against Fas , FasL , p 53 , Bcl 2 , and terminal deoxy transferase mediated dUTP nick end labeling ( TUNEL ) staining . ^^^ In cases of LOH , there was a preferential loss of the proline allele , which was associated with an up regulation of Bcl 2 and lack of co expression of Fas / FasL and , thus , impaired apoptosis ( P < 0 . 001 ) . ^^^ Homozygous proline 72 appears to be an important regulator of apoptosis via the Fas / FasL pathway in SCCHN . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Human dendritic cells mediate anti tumor activity against hematopoietic tumor cells without direct contact and Fas / FasL killing pathway . ^^^ The inhibitory activity of moDCs on Fas expressing tumor cells fully persisted after the neutralization of FasL . ^^^ These results suggest that moDCs can mediate a direct anti tumor activity against hematopoietic tumor cells through cytostasis in absence of contact or through apoptosis without triggering the Fas / FasL pathway . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ligand ( FasL ) mediated apoptosis is an important element of tissue specific organ damage . ^^^ Although current approaches prevent Fas receptor signaling by excluding FasL binding to Fas , the small molecule mimetics reported here disable Fas by promoting a defective Fas FasL receptor complex . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
During thymic selection ' mis selected ' CD 8 ( + ) T cells exit to the periphery where they are deleted by a Fas / FasL mediated mechanism , presumably as a result of activation by self antigens . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Correlations between local expression of insulin like growth factor 1 , insulin like growth factor receptor , epithelial growth factor , transforming growth beta 2 factor , PCNA , TNF alpha , TNF receptor 1 , Fas , FasL , IFN gamma , IL 1beta , IL 4 , IL 6 , IL 8 , IL 10 , and IL 12 genes in intact and hyperplastic endometrium and in the endometrium after hormone therapy were analyzed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The implication of the Fas pathway in this lysis was strengthened by both the blockage of cytotoxicity in the presence of anti Fas ligand ( FasL ) monoclonal antibody ( mAb ) and the up regulation of FasL expression on iNKT cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Skin from aged participants ( n = 14 ; mean 70 . 7 years ) , and young participants ( n = 14 ; mean 23 . 4 years ) was grafted to beige SCID mice , and epidermal thickness , proliferation ( Ki 67 expression ) , apoptosis ( TUNEL [ Tdt mediated dUTP nick end labeling ] reaction below granular layer ) , and expression of Fas and FasL were determined by histology and immunochemical staining . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
IFN gamma inhibits the proliferation of allergen activated T lymphocytes from atopic , asthmatic patients by inducing Fas / FasL mediated apoptosis . ^^^ We investigated the effect of recombinant IFN gamma on proliferation , Fas / Fas ligand ( FasL ) expression , and apoptosis in allergen stimulated peripheral blood mononuclear cells obtained from atopic , asthmatic patients and nonatopic , control subjects . ^^^ IFN gamma induced an increase in the expression of Fas and FasL by allergen stimulated CD4+ T cells from asthmatic patients and caused the apoptosis of these cells . ^^^ These results suggest that IFN gamma inhibits the proliferation of allergen stimulated CD4+ T cells from atopic , asthmatic patients by inducing the surface expression of Fas and FasL , which in turn triggers their apoptotic program . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
After HuIFN beta exposure , COH and CC M 2 cells showed increased levels of Fas and FasL proteins , alteration of mitochondrial membrane potential , and activation of caspase 9 , caspase 8 , and caspase 3 in a time dependent manner . ^^^ These results suggest that in COH and CC M 2 colon cancer cell lines , HuIFN beta induces apoptosis mainly through mitochondrial membrane alteration and subsequent activation of the caspase cascade pathway , but not by the Fas / FasL interaction or the p 53 dependent apoptotic mechanism . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To study the role of Fas Fas ligand ( FasL ) interaction mediated apoptosis in lymphocyte homeostasis , we generated a mutant fas allele allowing conditional inactivation of the fas gene through Cre mediated recombination . ^^^ Selective inactivation of Fas in T cells led to a severe lymphopenia over time , accompanied by up regulation of FasL on activated T cells and apoptosis of peripheral lymphocytes . ^^^ Inhibition of Fas FasL interaction in vivo completely prevented the loss of lymphocytes and initial lymphocyte infiltration in the lungs . ^^^ Thus , FasL mediated interaction of activated , Fas deficient T cells with Fas expressing cells in their environment leads to break down of lymphocyte homeostasis and development of a lung disease strikingly resembling idiopathic pulmonary fibrosis in humans , a common and severe disease for which the mutant mice may serve as a first animal model . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The other death receptor derived peptides , which are the corresponding regions of TNFR 1 and Fas , also showed specific binding to TNF alpha and FasL and inhibited the ligand induced cell death , respectively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The apoptosis of tumor cells and the expressions of p 53 , Fas and FasL were examined by flow cytometry . ^^^ RESULTS : Compared with the control group , in ADM MAM targeting therapy group and combination therapy ( ADM MAM and rhIL 2 therapy ) group , tumor weight , killer activity of NK cells , and the lymphocyte transformation ; were obviously decreased ; while the expression of Fas , FasL , IL 2 and IL 12 were markedly increased . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVES : To investigate the incidence of Fas ( exon 9 ) mutations and the expression of Fas , Fas Fas ligand ( FasL ) system , and cellular FLICE like inhibitory protein ( c FLIP ) in relation to standard clinicopathologic parameters and patient outcome in bladder carcinoma . ^^^ The FasL system is involved in the execution of apoptosis induced by the immune system . c FLIP protein constitutes an important endogenous inhibitor of Fas and other death receptor mediated apoptosis . ^^^ METHODS : The expression of Fas , FasL , and c FLIP was quantified immunohistochemically in paraffin embedded tissues from 53 patients for whom clinical information was available . ^^^ The effect of Fas , FasL , and c FLIP on clinical outcome was assessed by univariate and multivariate analyses . ^^^ RESULTS : Positive immunostaining was detected for Fas , FasL , and c FLIP in 72 % , 66 % , and 81 % of cases , respectively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Neutrophils are susceptible to apoptosis via Fas and an interaction between Fas and FasL was suggested originally as a mechanism to explain constitutive neutrophil apoptosis . ^^^ An elevated susceptibility to undergo apoptosis was observed following cross linking of Fas , which correlated both with viral load and co expression of Fas / FasL surface molecules . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The high purified Sertoli cells were isolated from the testis tissue of wild type mice , comparing apoptotic capability of Fas ( + ) Jurkat cells mediated by FasL ( + ) Sertoli cells of wild control and wild UU infected groups . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVES : To investigate the role of the Fas / Fas ligand ( FasL ) system as a signal transduction pathway leading to apoptosis after spinal cord injury . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Re : Polymorphisms of death pathway genes FAS and FASL in esophageal squamous cell carcinoma . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cardiomyocyte necrosis and / or apoptosis via activated tumor necrosis factor ( TNF ) and the Fas / Fas ligand ( FasL ) system may be related to the development of OMD . ^^^ CONCLUSION : OMD detected by H FABP , a marker of membrane damage , is related to activated TNF and the Fas / FasL system , which suggests a pathophysiological role of cardiomyocyte necrosis and / or apoptosis in patients with worsening heart failure . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas and FasL corresponds to these low intensity foci , but not those with high intensity , suggesting that activation of this death receptor may be specifically involved in molecular control of the low intensity foci . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression and distribution of Fas and Fas L in the nasal polyps ] . ^^^ OBJECTIVES : To confirm the expression and distribution of Fas and Fas L in the nasal polyps and to illustrate the role of the Fas / Fas L system in the pathogenesis of human nasal polyps . ^^^ METHODS : Investigating the transcripts of the Fas / Fas L gene in 30 human nasal polyp tissues and 30 nasal turbinate mucosa specimens using reverse transcription polymerase chain reaction . ^^^ Localization of Fas / Fas L was performed with immunohistochemistry . ^^^ RESULTS : The transcripts of the Fas / Fas L gene were detected at similar levels in both polyps and nasal mucosa . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : Biliary carcinoma cells produce the transmembrane proteins , Fas , FasL , and RCAS 1 . ^^^ It has been demonstrated that the Fas / FasL and RCAS 1 systems induce apoptosis of activated immune cells and that the soluble isoforms of these proteins ( sFas , sFasL , and sRCAS 1 ) also exhibit this function . ^^^ CONCLUSIONS : Our data suggest that serum sFasL in biliary disease may be derived predominantly from activated immune cells and not from cancer cells and that autoimmune biliary disease may be mediated by the Fas / FasL apoptotic system . sRCAS 1 is highly tumor specific and may be of value in the diagnosis of malignancy . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This different response to CDDP in caspase 8 activation was not related with the expression level of either Fas or FasL in these cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Semi quantitative reverse transcriptase polymerase chain reaction ( RT PCR ) analysis was employed to compare the mRNA expression levels of Fas / FasL and Bcl 2 / Bax in HSCs of each group . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas , FasL and hTERT were evaluated by RT PCR . ^^^ Fas was undetectable with PCR , whereas FasL was positive . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The effects of the combined use of angiotensin converting enzyme inhibitor ( ACEI ) benazepril and angiotensin 2 type 1 receptor antagonist ( AT1RA ) valsartan on apoptosis and the expression of apoptosis related proteins Fas and FasL in the kidney of rats with adriamycin induced nephritic glomerulosclerosis was investigated . ^^^ Immunohistochemistry was adopted to detect the expression of Fas and FasL . ^^^ Software of pathological analysis quantitated the levels of Fas and FasL . ^^^ The results showed that as compared with those in the control group , the kidneys in the model group had more severe glomerulosclerosis , much more apoptotic cells and higher levels of expression of Fas and FasL . ^^^ The degree of glomerulosclerosis , the number of apoptotic cells and the levels of expression of Fas and FasL were reduced by benazepril and valsartan . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This study was undertaken to determine whether intraluteal progesterone ( P 4 ) is involved in Fas L mediated luteal cell death in the bovine corpus luteum ( CL ) in vitro . ^^^ Luteal cells obtained from the cows in the midluteal phase of the estrous cycle ( Days 8 12 of the cycle ) were exposed to a specific P 4 antagonist ( onapristone [ OP ] , 10 ( 4 ) M ) with or without 100 ng / ml Fas L . ^^^ Although Fas L alone did not show a cytotoxic effect , treatment of the cells with OP alone or in combination with Fas L resulted in killing of 30 % and 45 % of the cells , respectively ( P < 0 . 05 ) . ^^^ DNA fragmentation was observed in the cells treated with Fas L in the presence of OP . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To explore relevant immunologic mechanisms occurring in KGCR , we have analyzed in surgically removed KG the transcription of the following cytokine and apoptotic molecule genes : interleukin ( IL ) 2 , IL 3 , IL 4 , IL 5 , IL 6 , IL 10 , tumor necrosis factor ( TNF ) alpha , IFN gamma , FAS , and FAS L . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Dehydroepiandrosterone induces apoptosis of thymocyte through Fas / Fas L pathway . ^^^ The results showed that DHEA could enhance the expression of Fas and Fas L and induce thymocyte apoptosis . ^^^ This suggests that dehydroepiandrosterone may induce the apoptosis of thymocyte through Fas / Fas L pathway . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Therefore , we investigated the effect of H . pylori on the expression of TRAIL , FasL and their receptors ( TRAIL R 1 R4 , Fas ) in gastric epithelial cells and examined their role in apoptosis . ^^^ CONCLUSIONS : Next to FasL and Fas , TRAIL and all of its receptor subtypes are expressed in the human stomach and differentially modulated by H . pylori . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS AND RESULTS : We analyzed the expression of apoptotic genes such as BAX , CASP 1 , FAS , FAS L , FOS , MDM 2 , NFkB 2 , P 53 , PCNA , TERT , and XRCC 1 in coronary plaques collected with directional coronary atherectomy from 15 patients with stable angina and 15 with acute coronary syndromes without ST elevation ( ACS ) . ^^^ Gene expression analysis showed that the proapoptotic genes ( ie , BAX , CASP 1 , FAS , FAS L , FOS , NFkB 2 , P 53 , PCNA ) were significantly more expressed ( P < 0 . 001 ) in ACS plaques , whereas the antiapoptotic genes ( ie , MDM 2 , TERT , XRCC 1 ) were more transcribed ( P < 0 . 001 ) in stable angina plaques . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Using electron spin resonance ( ESR ) spectroscopy , we showed that activation of Fas receptor by its ligand ( FasL ) in macrophages resulted in a rapid and transient production of hydrogen peroxide ( H2O2 ) and hydroxyl radicals ( * OH ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To evaluate the role of a major pathway of cell death Fas ( CD 95 ) / FasL in the pathogenesis of CIA , DBA / 1J mice with a mutation of the Fas gene ( lpr ) were generated . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RESULTS : ( 1 ) T lymphocyte apoptosis rate of corticosterone treated rats was higher than that of the normal control rats ; T lymphocyte apoptosis rates of Youguiyin treated rats and Bushen Yishou Capsule treated rats were lower than that of the corticosterone treated group ; T lymphocyte apoptosis rate of Sijunzi Decoction treated rats displayed no significance compared with that of the corticosterone treated group . ( 2 ) Pro apoptotic genes such as Fas , FasL , TNFR 1 , and Bax displayed increased expression level in corticosterone treated group compared with normal control group . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this study , we investigated the role of Fas FasL interaction in DST induced tolerance to H Y Ag . ^^^ METHODS : C57BL / 6 ( B 6 ) or B 6 Fas ( lpr ) ( lpr ) female mice were intravenously injected with B 6 , lpr , or B 6 FasL ( gld ) ( gld ) male spleen cells ( SC ) . ^^^ CONCLUSIONS : These findings suggest that the interaction between FasL upon infused SC , especially upon B cells and Fas in a recipient , is essential in DST induced tolerance to H Y Ag . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , upregulation of death and Fas was not accompanied by upregulation of FasL , pointing to the possible existence of FasL independent Fas associated death in these cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The pro apoptotic protein Fas , FasL , Bax and the anti apoptotic protein Bcl 2 , Bcl 10 ( L ) , Bcl 2 alpha were studied immunohistochemically by SP method . ^^^ RESULTS : The expression of proapoptotic proteins ( Fas , FasL , Bax ) in hepatocytes was significantly higher in the chronic hepatitis group than in the cirrhosis group ( P < 0 . 001 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , no differential expression of Fas and FasL was detected in monolayers and pseudoislets . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , the different agents had no effect when cell death was triggered by FasL , the natural ligand of Fas that does not generate SDS resistant forms of Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Our previous and other studies have shown expression of Fas by increased numbers of activated decidual CD 4 ( + ) T cells in both complete and partial molar pregnancy as well as increased FasL ( + ) expression by molar trophoblasts compared with trophoblasts in normal pregnancies . ^^^ As the Fas / FasL system represents a major apoptotic pathway that can play a role in immune privilege , the aim of this study was to investigate whether apoptosis of decidual immune cells , particularly T cells , could be responsible for maternal immune tolerance in molar pregnancy . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas , FasL , and perforin expressing cells were assessed by immunoperoxidase , and with anti CD 3 , anti CD 20 and anti CD 68 , by double immunofluorescence with confocal microscopy . ^^^ CONCLUSIONS : Increased expression of FasL in IBD colonic LP not parallelled by Fas on T cells and macrophages may indicate a reduced susceptibility to the Fas / FasL mediated apoptosis of lymphoid cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Moreover , pre treatments with 10 microg / ml of the antagonistic anti Fas DX 2 and ZB 4 monoclonal antibodies ( mAbs ) , and the neutralizing anti Fas ligand ( FasL ) NOK 1 mAb are all unable to prevent DAU and TT 13 from inducing Cyt c release and caspase 2 , 8 and 9 activities , suggesting that the Fas FasL signaling pathway is not involved in the mechanism by which these quinone antitumor drugs trigger apoptosis in HL 60 cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
High molecular weight plasma proteins induce apoptosis and Fas / FasL expression in human proximal tubular cells . ^^^ The involvement of the Fas / Fas ligand ( FasL ) system was also investigated . ^^^ Fas and FasL expression was analysed by western blotting . ^^^ PTECs exposed to the 100 440 and the 30 440 kDa fractions showed a significant upregulation in the expression of Fas and FasL . ^^^ These effects may be mediated at least in part by overexpression of the Fas / FasL system . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Neutrophil apoptosis is induced by endogenous ligands such as Fas ( FasL ) , which engage death receptors of the tumor necrosis factor / nerve growth factor superfamily , including Fas receptor ( FasR ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here we explore the protective role of the two main cytolytic pathways of CTL , that is , granule exocytosis and Fas / Fas ligand ( FasL ) , in acute and persistent Friend retrovirus ( FV ) infection of mice . ^^^ For this purpose , we have used mutant mouse strains with targeted gene defects in one or more components of the two cytolytic pathways including perforin , granzyme A , granzyme B , Fas , and FasL . ^^^ Most notably in the presence of Fas / FasL each of the three effector molecules of the exocytosis pathway ( i . e . , perforin , granzyme A , and granzyme B ) was capable on its own to mediate suppression of virus replication and protection from leukemia . ^^^ In contrast to acute infection the Fas / FasL pathway was mandatory for effective control of FV replication during persistent infection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
When deprived of trophic support , embryonic spinal motoneurons in vitro over express FasL , a ligand activating a Fas mediated death pathway . ^^^ Death is reduced in Fas and FasL mutant motoneurons and in the presence of JNK inhibitors indicating that a significant part of it requires activation of the Fas / FasL pathway through JNK . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cytokines released from islet infiltrating mononuclear cells are known to be cytotoxic both directly and by upregulating Fas for FasL induced apoptosis . ^^^ In summary , exposure of NOD mouse insulinoma cells or islets to IL 1 beta and IFN gamma for 24 h induced caspase 3 like activity that , in the case of insulinoma cells at least , can be further enhanced by interaction of cytokine induced Fas receptor with FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Germline mutations in Fas and Fasl induce nonmalignant T cell hyperplasia and systemic autoimmunity and also greatly increase the risk of B cell neoplasms . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We found NCTD did not induce Fas and FasL , implying that it activated other apoptosis pathways . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The number of positive cell for CD 3 , CD 4 , CD 8 , CD 25 , CD 28 , CTLA 4 ( CD 152 ) , Fas , FasL , bcl 2 , bcl 10 were determined using immunohistochemical staining techniques . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas ( APO 1 / CD95 ) and its ligand ( FasL ) are cell surface proteins whose interaction activates apoptosis of Fas expressing targets . ^^^ In T cells , the Fas Fas L system regulates activation induced cell death , is implicated in diseases in which lymphocyte homeostasis is compromised , and plays an important role during cytotoxic and regulatory actions mediated by these cells . ^^^ In this study we describe the effect of hyperthermia on activation of the fas L gene in T lymphocytes . ^^^ We show that hyperthermic treatment enhances Fas L mediated cytotoxicity , fas L mRNA expression , and fas L promoter activity in activated T cell lines . ^^^ Moreover , we found that heat shock factor 1 is a transactivator of fas L promoter in activated T cells , and the overexpression of a dominant negative form of heat shock factor 1 may attenuate the effect of hyperthermia on fas L promoter activity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
After 42 days , creatinine clearance ; blood CsA level ; apoptosis ; inflammation and tubulointerstitial fibrosis in renal tissue ; and the expression of Bax , Bcl 2 , Fas , FasL , and transforming growth factor ( TGF ) beta protein were determined . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here we report that : ( 1 ) HDACIs induce apoptosis of leukemic blasts , although oncogene expression is not sufficient to confer HDACI sensitivity to normal cells ; ( 2 ) apoptosis is p 53 independent and depends , both in vitro and in vivo , upon activation of the death receptor pathway ( TRAIL and Fas signaling pathways ) ; ( 3 ) TRAIL , DR 5 , FasL and Fas are upregulated by HDACIs in the leukemic cells , but not in normal hematopoietic progenitors . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To determine whether phenotypic field changes occur in tissues adjacent to carcinoma , we assayed , by immunohistochemistry , the expression of HER 2 , p 53 , Fas , and FasL in 72 breast cancers ( BC ) and multiple autologous peritumoral tissues ( PTTs ) sampled up to 5 cm distance and in 44 benign breast tumors ( BBTs ) . ^^^ Fas , highly expressed in BBTs and downregulated in BC , maintained its expression in PTTs , whereas FasL , usually negative in BBTs , was upregulated in BC as well as in the PTTs closest ( 1 cm ) to the invasive lesion . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Examination of luteal tissue for FasL / Fas death receptor cascade revealed increased expression of FasL and Fas at 18 h accompanied by a significant ( p < 0 . 05 ) induction in the caspase 8 activity and truncated Bid levels . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
PURPOSE : The authors have previously shown that apoptosis of stromal cells is downregulated in the lumican null mouse and that this may be due to disruption of Fas Fas ligand ( FasL ) signaling . ^^^ CONCLUSIONS : The data suggest that lumican binds FasL and facilitates induction of Fas . ^^^ Poor signaling through Fas FasL in lumican deficiency leads to impaired induction of inflammatory cytokines and corneal healing . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These include Fas L and nitric oxide ( NO ) . ^^^ Activated macrophages express surface Fas L , similar to cytotoxic T lymphocytes and natural killer cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
To elucidate molecular events in the apoptosis , protein expressions of Bcl 2 , Bax , Fas , and FasL were measured by western blotting using specific antibodies in HL 60 cells . ^^^ The level of Bcl 2 indicated down regulation , but the Bax , Fas , and FasL expression showed up regulation as compared with the untreated control cells . ^^^ These data support the idea that endomorphins induce apoptosis in HL 60 cells through the activation of the Bcl 2 Bax and the Fas FasL pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In T lymphocytes , the role of Akt in regulating Fas / Fas ligand ( FasL ) mediated apoptotic signaling and death is not clearly understood . ^^^ In this study , we observed that inhibition of Akt causes enhanced expression of FasL mRNA and protein and increased death inducing signaling complex ( DISC ) formation with Fas associated death domain ( FADD ) and procaspase 8 recruitment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , it was found that acacetin promoted the up regulation of Fas and FasL prior to the processing and activation of pro caspase 8 and cleavage of Bid , suggesting the involvement of a Fas mediated pathway in acacetin induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recent studies have shown the involvement of the Fas system ( Fas receptor and its ligand FasL ) in cancerous processes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We now show that in murine thymocytes , sulindac sulfide induced cell death is p 53 , bax , Fas , and FasL independent . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Systemic administration of SP 600125 , a small molecule JNK specific inhibitor , diminished JNK activity after ischemia and dose dependently reduced infarct volume . c Jun N terminal kinase inhibition also attenuated ischemia induced expression of Bim , Hrk / DP5 , and Fas , but not the expression of Bcl 2 or FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The death ligands FasL and tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) induce apoptosis by binding to their cognate cell surface death receptors Fas or death receptor ( DR ) 4 and DR 5 . ^^^ METHODS : The immunohistochemical expression and localization of Fas / FasL and DR4 / DR5 / TRAIL were assessed in 11 normal cervices , 15 cervical intraepithelial neoplasia ( CIN ) grade 1 , 15 CIN 2 , 13 CIN 3 , and 25 ( microinvasive ) squamous cell cervical cancers . ^^^ In normal cervix and CIN 1 samples , FasL , DR 4 , DR 5 , and TRAIL staining was mainly observed in the basal / parabasal layer , whereas Fas staining was localized in the superficial , more differentiated epithelial layer . ^^^ CONCLUSION : The loss of Fas and the deregulation of FasL , DR 4 , DR 5 , and TRAIL in the CIN cervical cancer sequence suggest a possible functional role of these death ligands and receptors during cervical carcinogenesis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
However , the extracellular redox state did not affect expression of Fas or FasL in hRPE cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In each group , the following analyses were performed : ( 1 ) the time course of changes in the cellular morphology , ( 2 ) the time course of occurrence of DNA fragmentation , ( 3 ) the appearance of apoptotic changes as evaluated by trypan blue staining , ( 4 ) Bcl 2 expression as examined by immunoblotting ; and ( 5 ) the expression of TNFR 1 , Fas , FasL and caspase 3 , 8 and 9 , as evaluated by immunoblotting . ^^^ Bcl 2 expression was seen only in the control group and FasL was never seen , while the expression of TNFR 1 , Fas and caspase 3 , 8 and 9 was seen in the amoxicillin treated group , clarithromycin treated group , amoxicillin and clarithromycin treated group and the positive control group . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Relationship of acute lung inflammatory injury to Fas / FasL system . ^^^ To evaluate the role of the apoptosis mediators Fas and FasL in acute lung injury , Fas ( lpr ) or FasL ( gld ) deficient and wild type mice were challenged with intrapulmonary deposition of IgG immune complexes . ^^^ These data suggest that the Fas / FasL system regulates the acute lung inflammatory response by positively affecting CXC chemokine production , ultimately leading to enhanced neutrophil influx and tissue damage . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
SNU 1 cells respond to resveratrol treatment with up regulation of both Fas and Fas L proteins , whereas in KATO 3 cells , with deleted p 53 , only Fas L is increased after resveratrol treatment . ^^^ Although Fas and Fas L proteins in SNU 1 cells and Fas L in KATO 3 cells were elevated within 24 h of cell treatment with low concentrations of resveratrol , significant apoptotic response at these concentrations was observed only after 48 h . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Specifically , the effects of 17beta estradiol on basal and LPS induced surface staining of Class 1 and 2 MHC , as well as CD 40 , CD 80 , CD 86 , CD 152 , CD 28 , CD 8 , CD11b , Fas , FasL , and also ERalpha and ERbeta , were examined in N 9 microglial cells . ^^^ The basal percentage of cells positive for MHC Class 1 and 2 , CD 40 , and CD 152 , Fas , and FasL was significantly decreased by estrogen exposure . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this study we assessed whether polymorphisms in the promoter region of Fas and FasL and sFas and sFasL are related to GBS or its distinct clinical or serological subgroups . ^^^ We show that the A ( 670 ) G SNP in the promoter region of Fas and high levels of sFas are associated with the presence of anti ganglioside antibodies , suggesting that Fas FasL interaction is involved in the production of cross reactive antibodies in GBS . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of Fas L in the cerebral cortex , thalamus , and hippocampi was detected by immunohistochemistry and the results were assessed by image analysis system . ^^^ RESULTS : It is showed that the expression of Fas L could be detected in 1 h after injury , and increased significantly in three hours , and it reached apex 12 h after injury , and decreased gradually four days after injury , and returned normal 14 days after injury . ^^^ CONCLUSION : This research demonstrated that Fas L mediated apoptosis appeared not only around brain trauma but also in the brain tissue far away from the traumatic area . ^^^ It indicted that the expression of Fas L is a useful target for diagnosis of early brain injury ; the regularity of Fas L expression could be used as one of indication to date the time of brain injury . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Surface trafficking of Fas or Fas L was not observed . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Protein expressions of Fas and FasL in B cell lymphoma and their significances ] . ^^^ BACKGROUND & OBJECTIVE : Fas and FasL have been proved to be the inductional genes of cell apoptosis . ^^^ Genesis of many tumors relates with functional disorder and abnormal expressions of Fas and FasL . ^^^ This study was designed to detect protein expressions of Fas and FasL in B cell non Hodgkin ' s lymphoma ( B NHL ) and benign lymphoid tissue , and to provide new markers for diagnosis of lymphoma . ^^^ METHODS : Immunohistochemistry was used to detect protein expressions of Fas and FasL in 92 specimens of B NHL , and 20 specimens of benign lymphoid tissue . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The gene expressions of Bax , Bcl 2 , Fas , FasL , Caspase 1 , 2 , 3 , and 9 , p 53 , and Smac / DIABLO were examined using a quantitative real time polymerase chain reaction method , while nuclear factor kappaB activity was examined using an electrophoresis mobility shift assay with a nuclear factor kappaB consensus sequenced DNA probe . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The contribution of the Fas / FasL apoptotic pathway in ulcer formation during Leishmania major induced cutaneous Leishmaniasis . ^^^ The expression of Fas and FasL and the levels of apoptosis in skin biopsies and in restimulated blood mononuclear cells from patients with 1 to 7 months of L . major induced CL were analyzed using immunohistochemistry and fluorescence activated cell sorting analysis . ^^^ The levels of soluble Fas and FasL were also analyzed by enzyme linked immunosorbent assay . ^^^ Supernatants from restimulated cultures induced apoptosis in human keratinocytes ( HaCaT ) , possibly through Fas / FasL interactions . ^^^ Our results indicate that FasL expressing effector T cells and macrophages may act to induce apoptosis and ulcer formation in Fas expressing keratinocytes during L . major infection . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL Fas clusters of high stability . ^^^ Using fluorescent variants of Fas and FasL , we show that membrane FasL and Fas form supramolecular clusters that are of flexible shape , but nevertheless stable and persistent . ^^^ Membrane FasL induced Fas clusters were formed in caspase 8 or FADD deficient cells or when a cytoplasmic deletion mutant of Fas was used suggesting that cluster formation is independent of the assembly of the cytoplasmic Fas signaling complex and downstream activated signaling pathways . ^^^ In contrast , cross linked soluble FasL failed to aggregate the cytoplasmic deletion mutant of Fas , but still induced aggregation of signaling competent full length Fas . ^^^ Moreover , membrane FasL induced Fas cluster formation occurred in the presence of the lipid raft destabilizing component methyl beta cyclodextrin , whereas Fas aggregation by soluble FasL was blocked . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / FasL play a central role in pancreatitis induced hepatocyte apoptosis . ^^^ AP was induced in National Institutes of Health ( NIH ) Swiss mice , C57 / C57 , and Fas / , FasL / mice by a choline deficient ethionine supplement diet . ^^^ Liver Fas , FasL , p 38 mitogen activated phosphokinase ( p 38 MAPK ) , poly ADP ribose polymerase ( PARP ) , and cytochrome C were measured by immunoblotting . ^^^ AP upregulated liver FasL ( 4280 + / 580 vs . 733 + / 336 ) , Fas ( 2866 + / 595 vs . 649 + / 111 ) , cytochrome C ( 6980 + / 237 vs . 903 + / 156 ) , and PARP ( 6393 + / 591 vs . 466 + / 261 ) as well as increased TUNEL staining ( 40 + / 2 vs . 14 + / 1 ) and DNA fragmentation ( all P < 0 . 03 vs . control ) . ^^^ In FasL / and Fas / mice , AP induced upregulation of p 38 MAPK , PARP , and cytochrome C was significantly attenuated ( all P < 0 . 01 compared to C57 / C57 control ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Polymorphisms in the promoter regions of FAS and FASL genes as candidate genetic factors conferring susceptibility to endometriosis . ^^^ One of the apoptotic pathways playing a crucial role in the programmed cell death within the endometrium is the Fas FasL system . ^^^ In this study we have performed a case control analysis in order to evaluate three polymorphisms located within FAS ( 1377G > A and 670A > G ) and FASL ( 843C > T ) genes , as susceptibility factors for endometriosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this study , we demonstrated that the cytotoxicity of human CD 8 ( + ) CTL against swine endothelial cells ( SEC ) is highly detrimental and mediated at least in part by the Fas / FasL pathway . ^^^ To prevent this CTL mediated xenocytotoxicity , we overexpressed the human decoy Fas antigen , which does not contain a death domain in its cytoplasmic region , by means of binding competition with endogenous pig Fas antigen on SEC for the common ligand , human FasL . ^^^ Both human decoy Fas and membrane bound FasL were effective to prevent CTL mediated killing , suggesting that these novel molecules may represent a step forward toward preventing CD 8 ( + ) CTL mediated xenograft rejection . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
These findings collectively suggest that Saf might protect T lymphocytes from Fas mediated apoptosis by blocking the binding of FasL or its agonistic Fas antibody . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Altered expression of membrane bound and soluble CD95 / Fas contributes to the resistance of fibrotic lung fibroblasts to FasL induced apoptosis . ^^^ Here , we studied the susceptibility of lung fibroblasts , obtained from patients with ( f fibs ) and without pulmonary fibrosis ( n fibs ) , to FasL ( CD95L / APO 1 ) induced apoptosis in relation to the expression and the amounts of membrane bound and soluble Fas . ^^^ RESULTS : When compared to n fibs , f fibs were resistant to FasL induced apoptosis , despite significantly higher levels of Fas mRNA . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In tumor tissue obtained from a group of 21 patients treated surgically for laryngeal carcinoma , the expression of Fas , Fas L , CD 3 , TCR zeta chain and Bcl 2 were estimated . ^^^ It has been shown that tumor often express : Fas L , Fas , Bcl 2 , the molecules which may influence increased tumor survival . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Nef mediated AIDS like disease of CD4C / human immunodeficiency virus transgenic mice is associated with increased Fas / FasL expression on T cells and T cell death but is not prevented in Fas , FasL , tumor necrosis factor receptor 1 , or interleukin 1beta converting enzyme deficient or Bcl 2 expressing transgenic mice . ^^^ In addition , expression of Fas and FasL , assessed by flow cytometry , was increased in CD 4 ( + ) and CD 8 ( + ) T cells from Tg mice compared to that of non Tg littermates . ^^^ Despite the enhanced expression of Fas and FasL on Tg CD 4 ( + ) and CD 8 ( + ) T cells , Fas ( lpr / lpr ) and FasL ( gld / gld ) mutant CD4C / HIV Tg mice developed an AIDS like disease indistinguishable from lpr / + and gld / + CD4C / HIV Tg mice , including loss of CD 4 ( + ) T cells . ^^^ These results represent genetic evidence for the dispensable role of Fas , FasL , ICE , and TNFR 1 on the development of both T cell loss and organ disease of these Tg mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The major finding are as following : ( 1 ) The mechanical stretch activated death receptor mediated apoptotic signaling in cardiomyocytes , including activation of caspases 8 , 9 and 3 , up regulation of Fas , FasL expression and cell surface trafficking of death ligands ( FasL and TRAIL ) ; ( 2 ) That exogenous death ligand ( TRAIL ) enhanced , while soluble death receptor ( sDR 5 ) neutralized , stretch induced apoptosis ; ( 3 ) Adenovirus delivered dominant negative FADD ( FADD DN ) significantly reduced apoptosis , caspases 8 , 9 , and 3 activation , and stretch induced cyt c release from mitochondria . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Western blotting and RT PCR were performed to detect the expression changes of Fas , FasL , caspase 10 p 20 , caspase 8 , 1 kappaB alpha , and p 1 kappaB alpha molecules in protein and mRNA levels , separately , and immunohistochemistry for molecular localization of Fas and FasL in rat hippocampus . ^^^ RESULTS : The expression of Fas , FasL , and caspase 10 p 20 in protein and mRNA levels increased after I / R , which was inhibited significantly after treatment with 20 and 40 mg 10 kg ( 1 ) of DIP ( P < 0 . 01 ) . ^^^ In 80 mg 10 kg ( 1 ) of DIP group , the expression of Fas and FasL protein was not significantly different from that of I / R group ( P > 0 . 05 ) . ^^^ DIP significantly affected molecular distribution of Fas and FasL protein in CA 1 subregion of hippocampus . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND & OBJECTIVE : Tumor cells can express FasL , and induce apoptosis of activated T cells expressing Fas , which is so called `` Fas counterattack ' ' . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The addition of 100 nM ouabain to cultures of peripheral blood lymphocytes activated with 5 microg / ml phytohemagglutinin ( PHA ) did not modify the increased expression of the Fas receptor or its ligand FasL induced by the mitogen . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Interestingly , the pro apoptotic activity of the drug is not due to the relief of oncogene mediated inhibition of the p 53 tumor suppressor pathway but , instead , relies on the selective upregulation of the death receptors DR 5 and Fas and their cognate ligands TRAIL and FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CONCLUSIONS : Polyclonal rATG increased apoptosis and production of the proapoptotic proteins fas and fasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The result also revealed increased phosphorylation in p 38 and c Jun , cytochrome c release , and expression of tBid , Fas , and FasL in the HAs treated HL 60 cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Distribution of Fas and FasL in the central nervous system of adult rhesus ] . ^^^ OBJECTIVE : To investigate the distribution of Fas and FasL in the CNS of adult rhesus . ^^^ METHODS : Frozen sections were incubated in polyclonal anti Fas and anti FasL antibody by the immunohistochemical SP method . ^^^ RESULTS : The Fas and FasL immunopositive neurons were observed in many areas . ^^^ Fas and FasL immunoreactivity mainly distributed in motor neurons of spinal ventral horn and neural fibers and glia cells in white matter . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Functional polymorphisms in cell death pathway genes FAS and FASL contribute to risk of lung cancer . ^^^ BACKGROUND : The FAS and FASL system plays a key role in regulating apoptotic cell death and corruption of this signalling pathway has been shown to participate in immune escape and tumorigenesis . ^^^ There is reduced expression of FAS but elevated expression of FASL in many types of human cancers including lung cancer . ^^^ We recently reported an association between functional polymorphisms in FAS ( 1377G > A ) and FASL ( 844T > C ) and risk of oesophageal cancer . ^^^ RESULTS : Compared with non carriers , there was a 1 . 6 fold excess risk of developing lung cancer for carriers of the FAS 1377AA genotype ( odds ratio ( OR ) 1 . 59 , 95 % confidence interval ( CI ) 1 . 21 to 2 . 10 ; p = 0 . 001 ) , and 1 . 8 fold excess risk ( OR 1 . 79 , 95 % CI 1 . 26 to 2 . 52 ; p = 0 . 001 ) for carriers of FASL 844CC . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , phorbol 12 myristate 13 acetate / ionomycin treatment induced surface expression of Fas L and TRAIL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Mousepox conjunctivitis : the role of Fas / FasL mediated apoptosis of epithelial cells in virus dissemination . ^^^ The presence of ECTV MOS antigens in the epithelium of conjunctivae significantly upregulates Fas in the epithelial layer and FasL in the suprabasal layer of conjunctiva . ^^^ Inhibition of FasL with blocking antibodies in cultures of conjunctival cells isolated from ECTV MOS infected BALB / c mice showed that the Fas / FasL pathway is important in apoptosis of ECTV MOS infected cells . ^^^ These results suggest that not only is Fas / FasL expression in conjunctiva involved in elimination of migrating Fas+ cells but also plays an important role in the turnover of conjunctival epithelium and thus may be crucial for ECTV spreading to the surrounding environment . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , testosterone decreased cell viability by way of apoptosis , accompanied by increased Fas , FasL , and Caspase 8 expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
CS triggered activation of MAP kinase ( p38 / JNK or ERK 2 ) pathway , which led to Jun or p 53 phosphorylation and FasL induction links Fas phosphorylation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recent findings have implicated Fas / Fas ligand ( FasL ) in mediating the death of keratinocytes in spongiotic lesions . ^^^ Using a variety of inhibitors and blocking antibodies , we demonstrated that : ( 1 ) apoptosis is required for the generation of the signal ( s ) leading to the activation of EGFR , ERK , and Akt ; ( 2 ) the activation of EGFR , ERK , and Akt by FasL is indeed mediated by its bona fide receptor Fas ; ( 3 ) the activation of EGFR is essential for the subsequent activation of ERK and Akt ; and ( 4 ) apoptotic keratinocytes secrete soluble EGFR ligands ( including amphiregulin ) that are processed from membrane bound proligand forms by metalloproteinase ( s ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
AIM : To evaluate the expressions of apoptotic signal proteins FADD , TRADD , FasL , Fas , and NFkappaB in gastric carcinoma tissues and their clinical significance . ^^^ METHODS : Western blot immune trace method was adopted to detect the expressions of apoptotic signal proteins FADD , TRADD , FasL , Fas , and NFkappaB in 55 tissue specimens of gastric carcinoma . ^^^ Expressions of the FADD , FasL , Fas , and NFkappaB proteins reduced with increase of the volume of tumor with the exception of increased expression the TRADD protein ( 64 . 7 71 . 1 % , P = 0 . 031 ) . ^^^ With gradual increase of the malignancy of gastric carcinoma tissues , expressions of the FADD , FasL , and Fas proteins decreased ( 78 . 6 28 . 0 % , P = 0 . 008 ; 78 . 6 65 . 9 % , P = 0 . 071 ; 100 . 0 46 . 3 % , P = 0 . 014 ) , while expressions of the TRADD and NFkappaB proteins increased ( 42 . 9 78 . 1 % , P = 0 . 063 ; 78 . 6 79 . 1 % , P = 0 . 134 ) . ^^^ With gradual increase of serum CEA , expression of the FADD protein decreased ( 62 . 5 34 . 0 % , P = 0 . 073 ) , but expressions of the TRADD , FasL , Fas , and NFkappaB proteins increased ( 0 . 0 80 . 8 % , P = 0 . 005 ; 62 . 5 70 . 2 % , P = 0 . 093 ; 0 . 0 70 . 2 % , P = 0 . 003 ; 62 . 5 80 . 9 % , P = 0 . 075 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
On the basis of these results , the involvement of the Fas / Fas ligand ( FasL ) death receptor pathway , in MEM induced apoptosis in HepG 2 cells , was investigated . ^^^ These results demonstrate that MEM induces HepG 2 apoptosis through inhibition of cell growth and up regulation of Fas / FasL to activate the pathway of caspase 3 and 8 cascades . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression levels of Fas , FasL , and FADD were not changed by the treatment with cisplatin . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Nonylphenol induced thymocyte apoptosis is related to Fas / FasL pathway . ^^^ In this study , to determine the immunological effects of NP , the effects of NP on apoptosis and Fas / FasL gene expression in rat thymocyte in vitro were investigated . ^^^ A semi quantitative reverse transcriptase polymerase chain reaction method was used to analyze Fas and FasL mRNA levels . ^^^ Fas and FasL protein expression was evaluated by flow cytometry . ^^^ The results showed that NP decreased the cellularity ; induced apoptotic death and enhanced the expression of Fas and FasL mRNA as well as proteins in thymocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In contrast , Fas mediated activation of JNK , p 38 , and p42 / 44 occurred essentially independent from IFN gamma sensitization , indicating that the apoptosis and NF kappaB related FasL IFN gamma cross talk was not due to a simple global enhancement of Fas signaling . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas triggers apoptosis via the caspase cascade when bound to its ligand FasL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We studied local expression of insulin like growth factor 1 , insulin like growth factor receptor , epithelial growth factor , transforming growth factor beta 2 , PCNA , TNF alpha , type 1 TNF receptor , Fas , FasL , IFN gamma , IL 1beta , IL 4 , IL 6 , IL 8 , IL 10 , and IL 12 genes in intact and hyperplastic endometrium . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Rat cerebellar granule neurons ( CGNs ) express high levels of Fas in vitro but are resistant to FasL ( CD95L / APO 1L / CD178 ) induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression and clinical significance of nm 23 H1 , Fas and FasL in colorectal carcinoma tissues ] . ^^^ OBJECTIVE : To investigate the expression and clinical significance of nm 23 H1 , Fas and FasL in colorectal carcinoma tissues . ^^^ METHODS : The expression levels of nm 23 H1 , Fas and FasL in 48 cases of colorectal carcinoma tissues and 15 cases of normal colorectal tissues were determined by SP immunohistochemical staining . ^^^ CONCLUSION : These results suggest that the lower expression of nm 23 H1 and Fas and higher expression of FasL may be used as a good indicator in evaluating lymph node metastasis and prognosis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
METHODS : Western blotting and a well characterized cofocal scanning image were performed to analyze the expression of Fas / FasL and caspase 3 in co cultured Bel 7402 and Jurkat cells . ^^^ RESULTS : After co culture with Jurkat cells , up regulated Fas and reduced FasL expression could be observed . ^^^ Treatment with AFP could remarkably inhibit the elevated Fas and , whereas , induce the FasL expression in co cultured Bel 7402 cells . ^^^ Monoclonal antibody against AFP treatment alone did not obviously influence the growth of cells , as well as the expression of Fas / FasL and caspase 3 . ^^^ CONCLUSIONS : our results provide evidence that AFP could promote the escape of liver cancer cells from immune surveillance through blocking the caspase signal pathway of tumor cells and triggering the Fas / FasL interaction between tumor cells and lymphocytes . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Estrogens up regulate the Fas / FasL apoptotic pathway in lactotropes . ^^^ The Fas / FasL system provides the major apoptotic mechanism for many cell types , participating in cell turnover in hormone dependent tissues . ^^^ In the present study , we localized both Fas and FasL in anterior pituitary cells , mainly in lactotropes and somatotropes . ^^^ The percentage of anterior pituitary cells showing immunoreactivity for Fas or FasL was higher in cells from rats killed in proestrus than in diestrus . ^^^ Also , the proportion of pituitary cells from ovariectomized ( OVX ) rats expressing Fas or FasL increased in the presence of 17beta estradiol ( 10 ( 9 ) M ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Treatment of the Fas resistant NHL cell lines ( 2F7 , Ramos and Raji ) with rituximab sensitized the cells to CH 11 ( FasL agonist mAb ) induced apoptosis and synergy was achieved . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
SJS and TEN are usually initiated by drugs , and the tissue damage is mediated by soluble factors including Fas and FasL . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Immunohistochemistry was performed for cell cycle regulators [ p 53 , p 21 , p 27 , p 16 , cyclin D 1 , Rb ] , apoptosis related proteins [ Fas , Fas L , FADD , TRAIL , DR 4 , DR 5 , caspase 8 , caspase 3 , bcl 2 , Bax ] , tumor suppressor proteins [ beta catenin , E cadherin , FHIT , Smad 4 , VHL , PTEN , KAI 1 ] , and oncoproteins [ c myc , COX 2 , EGFR ] . ^^^ Caspase 3 , TRAIL , Fas L , Fas , Smad 4 , VHL , E cadherin , and EGFR revealed significant differences between dysplasia and their corresponding invasive cancer portion in 25 cases . ^^^ In conclusion , caspase 3 , TRAIL , Fas L , Fas , Smad 4 , VHL , E cadherin , and EGFR may be involved in the progression from dysplasia to invasive esophageal SCCs . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Hyperoxia induced apoptosis and Fas / FasL expression in lung epithelial cells . ^^^ In view of functional involvement of Fas / FasL system in physiological postcanalicular type 2 cell apoptosis , we speculated this system may also be a critical regulator of hyperoxia induced apoptosis . ^^^ Fas / FasL expression was determined by Western blot analysis and RPA . ^^^ The apoptotic stage was associated with a threefold upregulation of Fas mRNA and protein expression and increased susceptibility to direct Fas receptor activation , concomitant with a threefold increase of FasL protein levels . ^^^ In murine fetal type 2 cells , hyperoxia similarly induced markedly increased Fas / FasL protein expression , confirming validity of results obtained in transformed MLE 12 cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We have tested polymorphisms and haplotypes in FAS and FASL for association to SLE or subphenotypes in 126 multiplex American SLE pedigrees and found association of the FAS codon 214 AC ( C / T ) as well as the FAS 670G > A ' codon 214 AC ( C / T ) ' haplotype to thrombocytopenia in SLE . ^^^ Furthermore we have functionally characterized the FAS / FASL promoter polymorphisms associated with SLE in other populations and demonstrate that the activity depends on the allelic variants as well as on the haplotype . ^^^ We conclude that the FAS / FASL promoter haplotypes are functional and that polymorphisms in FAS may contribute to thrombocytopenia in SLE . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Ircinin 1 also induced cytochrome c release , cleavage activations of caspase 3 and 9 , and upregulation of Fas and Fas L . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Involvement of Fas and FasL in Ectromelia virus induced apoptosis in mouse brain . ^^^ Expression of Fas / FasL was significantly increased on ECTV MOS infected cells between 5 and 15 d . p . i . , whereas Fas was up regulated also on the surrounding , non infected cells . ^^^ Taking together we may conclude that ECTV MOS infection of microglia and astrocytes leads to local inflammation resulting in Fas / FasL up regulation and apoptosis , which limits mouse central nervous system infection with ECTV MOS . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Maternal and umbilical serum soluble Fas and FasL concentrations were estimated using a sandwich ELISA assay . ^^^ Further studies are necessary to evaluate the role of Fas / FasL pathway in pregnancies complicated by preeclampsia and intrauterine growth retardation . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas mRNA expression was downregulated and FasL was upregulated in H37Ra and H37Rv infected macrophages , while Bcl 2 was upregulated in H37Rv infected macrophages but downregulated in H37Ra infected macrophages as seen by real time PCR . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The number of apoptotic cells in lung sections was determined by a TUNEL method . mRNAs for Fas , FasL and caspase 8 , and for Bad , Bax , Bcl w , Bcl xL and caspase 9 , for the FasL and the mitochondrial cytochrome c pathways of apoptosis , respectively , and mRNA for the effector caspase 3 were quantified in lung tissues by RT PCR . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Western analysis showed that mature red cells contain Fas , FasL , Fas associated death domain ( FADD ) , caspase 8 , and caspase 3 . ^^^ Circulating , aged cells showed colocalization of Fas with the raft marker proteins Galpha ( s ) and CD 59 ; the existence of Fas associated FasL , FADD and caspase 8 ; and caspase 8 and caspase 3 activity . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Treatment with mitomycin C resulted in the increased expression of Fas , FasL , Bad , and phosphorylated p 53 and a decreased level of phosphorylated AKT . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OBJECTIVES : CD34+ cells and colony forming unit granulocyte and macrophage ( CFU GM ) from human bone marrow were used to investigate the role of Fas / FasL system in the regulation of myelopoiesis . ^^^ METHODS : Fas and FasL expression in CD34+ cells and in day 14 CFU GM were measured by RT PCR and immunofluorescence respectively . ^^^ Fas and FasL expression were demonstrated using RT PCR and immunofluorescence respectively . ^^^ CONCLUSION : Fas , FasL , and caspase activation are likely to play an important role in the regulation of myelopoiesis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Analysis of the expression of Fas , FasL and Bcl 2 in the pathogenesis of autoimmune thyroid disorders . ^^^ To investigate the expression of apoptosis related protein ( Fas , FasL , and Bcl 2 ) in the pathogenesis of autoimmune thyroid disorders ( ATDs ) , immunohistochemical staining was performed on 20 Hashimoto ' s thyroiditis ( HT ) , 20 Graves ' disease ( GD ) , and 20 thyroid follicular adenoma ( TFA , as control ) . ^^^ In TFA , a moderate Fas expression and a minimal or no FasL expression was detected on follicular cells . ^^^ In HT , the follicles adjacent to infiltrating lymphocytes showed increased levels of Fas and FasL expression . ^^^ A weaker staining of Fas and FasL was exhibited on infiltrating lymphocytes than on thyrocytes . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Tissue microarray analysis of Fas and FasL expressions in human non small cell lung carcinomas ; with reference to the p 53 and bcl 2 overexpressions . ^^^ Fas and FasL expressions in 110 non small cell lung carcinomas ( NSCLCs ) were investigated to evaluate their roles in pulmonary carcinogenesis and to examine the clinicopathologic significance of Fas expression with its relationship with p 53 and bcl 2 overexpressions . ^^^ FasL protein was increased in most NSCLCs ( 89 % ) compared to normal lungs . p 53 and bcl 2 overexpressions showed no association with Fas expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
ELISA was employed to detect the levels of IL 10 in serum and the levels of sFas and sFasL in cultured PBMC supernatants , and the results of sFas and sFasL were confirmed by real time PCR of Fas and FasL mRNA . ^^^ The levels of sFas and sFasL in the culture supernatant and Fas and FasL mRNA expressions in cultured cells were significantly higher in the SLE serum cultured groups , but decreased evidently in the presence of the anti IL 10 antibody . ^^^ The high percentage of apoptotic T cells in SLE patients may be related to the high levels of IL 10 in SLE serum , as IL 10 may induce the abnormally activated T cells to trigger apoptosis via the Fas FasL pathway . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Pressure and endothelial coculture upregulate myocytic Fas FasL pathway and induce apoptosis by way of direct and paracrine mechanisms . ^^^ Our current hypothesis was that in EC SMC coculture , pressure upregulates SMC apoptosis SMCs through EC derived paracrine factors and that SMC apoptosis is induced through Fas Fas ligand ( FasL ) activation . ^^^ Fas and FasL expression was assessed in SMC grown in monoculture , coculture with EC , pressurized monoculture , and pressurized coculture with EC . ^^^ Pressure increased Fas and FasL expression in monocultured and cocultured SMCs ( 1 . 6 fold and 2 . 3 fold for Fas [ P < . 05 ] and 1 . 65 fold and 1 . 7 fold for FasL [ P < or = . 05 ] ) . ^^^ Coculture had synergistic effect on Fas expression and no effect on FasL expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here we show that stimulation of the Fas receptor by its ligand ( FasL ) results in rapid generation of NO and concomitant decrease in cellular FLICE inhibitory protein ( FLIP ) expression without significant effect on Fas and Fas associated death domain ( FADD ) adapter protein levels . ^^^ FLIP down regulation as well as caspase 8 activation and apoptosis induced by FasL were all inhibited by the NO liberating agent sodium nitroprusside and dipropylenetriamine NONOate , whereas the NO synthase inhibitor aminoguanidine and NO scavenger 2 ( 4 carboxyphenyl ) 4 , 4 , 5 , 5 tetramethyl imidazoline 1 oxyl 3 oxide ( PTIO ) had opposite effects , indicating an anti apoptotic role of NO in the Fas signaling process . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The Fas / Fas ligand ( FasL ) pathway has been largely implicated in the homeostasis of mature cells . ^^^ In this model , the consequences of a deficient Fas / FasL pathway on lymphoid differentiation could be evaluated without endogenous competition . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
AIM : To determine the role of Fas / Fas ligand ( FasL ) in the immune escape of colon cancer cells . ^^^ METHODS : Immunohistochemistry was used to observe the expression of Fas and FasL in the tissues of colon cancer patients . ^^^ RESULTS : Of 53 cases of colon carcinomas , 23 cases ( 43 . 4 % ) expressed Fas which was significantly lower as compared to the normal colonic mucosa ( 73 . 3 % , P < 0 . 01 ) , and 45 cases ( 84 . 9 % ) of colon carcinomas expressed FasL , whereas only two cases ( 3 . 75 % ) in normal mucosa expressed FasL . ^^^ CONCLUSION : Colon cancer cells can escape the immune surveillance and killing via decreasing Fas expression , and can counterattack the immune system via increasing FasL expression . ^^^ Fas / FasL can serve as potential targets for effective antitumor therapy . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expressions of p 53 and Bax ( pro apoptotic protein ) , Bcl 2 ( anti apoptotic protein ) , Fas , and Fas L ( apoptotic death receptor and ligand ) , caspase 3 ( apoptotic effector caspase proteins ) , and p 27 and p 21 ( cyclin dependent kinase inhibitors ) were analyzed using tissue array blocks . ^^^ The anti apoptotic protein , Bcl 2 , was expressed in 9 AVS ( 75 % ) and 11 UVS ( 73 % ) , and p 53 , Fas L , and caspase 3 were negative and Fas was positive in all AVS and UVS cases . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
They also decreased the expression and / or activation of Fas , FasL , TNF , caspase 3 , 8 , and 9 , Bid , and Bax . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Activation induced cell death ( AICD ) in activated T lymphocytes is largely mediated by Fas / Fas ligand ( FasL ) interaction . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis appeared to be mediated by the Fas / Fas L pathway , as neutralizing antibodies for Fas and Fas L significantly protected HUVECs against HCV LP induced apoptosis . ^^^ Treatment of HUVECs with HCV LPs also enhanced cellular Fas L expression and augmented caspase 3 activation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Bleomycin initiates apoptosis of lung epithelial cells by ROS but not by Fas / FasL pathway . ^^^ Glutathione and inhibitors of caspase 8 or caspase 9 , but not of FasL , inhibited these effects , suggesting their dependence on ROS , caspase 8 and 9 , in a Fas / FasL independent pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
As a result , activated JNK can not only phosphorylate the transcription factor c Jun and up regulate Fas L expression but can also phosphorylate 14 3 3 and promote Bax translocation to mitochondria , increase the release of cytochrome c and increase caspase 3 activation . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
H 2b splenocytes are recognized by the antiviral TcR as `` veto ' ' cells , which inhibit by an exquisitely virus specific , MHC restricted , veto cell FasL / responder T cell Fas , mediated apoptotic mechanism . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The mRNA levels of apotosis related genes ( fas , fasL , and bax ) and cell cycle related genes ( mdm 2 and p 21 ) were significantly elevated , and the degree to and sequence in which these target genes expressed was similar to those for fas , fasL , mdm 2 and p 21 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Soluble form of TRAIL , Fas and FasL in the serum of patients with B CLL . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Overexpression of thymosin beta 4 renders SW 480 colon carcinoma cells more resistant to apoptosis triggered by FasL and two topoisomerase 2 inhibitors via downregulating Fas and upregulating Survivin expression , respectively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this study , we investigated the polarization of T cell subsets , the expressions of apoptotic proteins Fas / FasL on the subsets and the level of anti apoptotic gene bcl 2 and bax mRNA . ^^^ In ITP children , the enhancing expressions were detected for FasL on Th 1 and Tc 1 and for Fas on Th 2 and Tc 2 . ^^^ This polarization pattern of T cell subsets might be related to the high ratio of bcl 2 / bax mRNA and the abnormal expressions of Fas and FasL on T cell subsets . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Synergistic effects on the inhibition of human CD8+ cytotoxic T lymphocytes mediated killing against xenograft cells by coexpression of membrane bound Human FasL and decoy Fas antigen . ^^^ We previously demonstrated that the Fas / FasL pathway is a major contributor to CD8+ CTL function . ^^^ Furthermore , we sought to prevent this cytotoxicity by overexpression of membrane bound FasL carrying the deletion at the metalloproteinase cleavage site or by decoy Fas antigen that does not contain the death domain in its cytoplasmic region . ^^^ Although cotransfectants and single transfectants of either membrane bound FasL or decoy Fas gene showed similar inhibition of cytotoxicity , the expression levels of decoy Fas in SEC cotransfectants were much lower than those of decoy Fas single transfectants . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Cytokines such as tumor necrosis factor alpha ( TNF alpha ) , FasL , and TNF related apoptosis inducing ligand ( TRAIL ) induce apoptosis or inflammation through binding to their specific receptors , TNFR 1 , Fas , and DR 5 , respectively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Despite exhibiting similar binding to both Fas and caspase 8 and preserved overall secondary structure , FADD RDXLL motif mutants can not reconstitute FasL or TRAIL induced apoptosis and fail to recruit caspase 8 into the DISC of reconstituted FADD deficient cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expressions of epidermal growth factor receptor ( EGFR ) , p 38 kinase , FAS , FasL and caspase 3 were detected using immunocytochemistry , and the NOS activity and the ratio of differentiated cells / proliferating cells were examined by cytochemistry . ^^^ Moreover , the signals of wt p 53 , iNOS , p 38 kinase , caspase 3 and NOS activity were significantly stronger , whereas , the signals of bcl 2 , c myc and Fas / FasL were markedly weaker in E 2 group than those in C 2 group ( P < 0 . 05 ) . ^^^ Furthermore , upregulation of FasL , p 38 kinase and caspase 3 as well as downregulation of bcl 2 , and Fas may be involved in the apoptosis of Eca 109 cells . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and FasL are both expressed in AECs , and their main function may be to control inflammation by inducing Fas induced death in inflammatory cells without inducing apoptosis in neighboring cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We investigated the respective role of the Fas / FasL and mitochondrial permeability transition pore ( mPTP ) pathways in cardiomyocyte apoptosis accompanying ACGR . ^^^ At day 5 , we assessed ACGR by histology , cardiomyocyte apoptosis by caspase 3 activity and cytochrome c release , Ca ( 2+ ) induced mPTP opening by a potentiometric approach , and expression of Fas , FasL , TNFalpha , perforin , granzyme using RT PCR . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Further , at concentrations of at least 100 microM , apoptosis was induced , and expressions of caspase 3 and proapoptotic genes , including Fas ( FasL ) and c fos , which trigger apoptosis through receptor mediated extrinsic and mitochondrion mediated apoptotic pathways , respectively , were increased . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A critical effector of apoptosis is the Fas / Fas ligand ( FasL ) system that mediates the tumoricidal effects of cytotoxic T cells . ^^^ In the present study , we first analyzed the influence of this metalloproteinase on Fas signaling in SW 480 , HCT 15 and HT 29 colorectal carcinoma ( CRC ) cells by assessing their responses to either an agonistic Fas antibody ( CH 11 ) or the FasL bearing Jurkat cells after they were pretreated with MMP 7 . ^^^ These results suggest that Fas downregulation and a consequential increased resistance to FasL triggered apoptosis resulting from upregulated MMP 7 in colorectal cancer cells could be a key mechanism for their escape from the immune surveillance , thereby predicting a poor survival in CRC patients . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Despite exhibiting phenotypic properties of antigen activated cells , including expression of Fas and FasL , T LGL cells accumulate and demonstrate resistance to apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
C5b 9 also down regulated the expression of FasL and the Fas induced apoptosis . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This neurotoxic effect was accompanied by up regulation of the proapoptotic proteins FasL , Fas , and Bad and the active fragments of caspases 8 and 3 in cortical and hippocampal lysates . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Hepatic mRNA levels were measured for several pro apoptotic adaptors / regulators , including FasL , Fas receptor , FADD , TRADD , Bad , Bak , Bax , and Bcl 10 ( S ) , and anti apoptotic regulators , including Bcl w , Bcl 10 ( L ) , Bcl 2 , and Bfl 1 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Recent evidence is supportive of a role for the death receptor Fas and its ligand FasL , in the pathogenesis of keratinocyte apoptosis during TEN . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Our results demonstrate increased FasL gene expression in oxidized clozapine induced apoptotic neutrophils suggesting that apoptosis in granulocytes treated with clozapine involves Fas / FasL interaction that initiates a cascade of events leading to clozapine induced agranulocytosis . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Furthermore , Fas and FasL were increased in the aortic samples from patients with aneurysms and dissections relative to control aortas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
RESULTS : Apoptotic proteins in tumors that showed positive staining were the highest for Bax ( 99 % ) , Fas ( 92 % ) , FasL ( 87 % ) , Rb ( 87 % ) , p 21 ( WAF 1 ) ( 73 % ) , and p 53 ( 70 % ) , and the lowest for c myc ( 58 % ) and Bcl 2 ( 58 % ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The expression of FasL , Fas , TNF related apoptosis inducing ligand ( TRAIL ) and TRAIL R 1 on erythroblasts decreased significantly during thalidomide treatment . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
PROBLEM : Activated lymphocytes can be eliminated by Fas / Fas ligand ( FasL ) induced cell death . ^^^ CONCLUSION : Because of Fas / FasL mechanisms , in the initial stages of endometriosis the activated peritoneal fluid CD56+ cells can be intensively eliminated , thus providing conditions for the survival of ectopic endometrial cells and the development of the disease . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Our results also showed that the levels of Fas and Fas L were increased , the pro caspase 3 and pro caspase 9 were down regulated in H ( 2 ) O ( 2 ) treated MGC 803 cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Stable SEC transfectants expressing either decoy Fas or membrane bound FasL were established . ^^^ The overexpression of either decoy Fas or membrane bound FasL in SEC markedly inhibited CTL xenocytotoxicity . ^^^ The double expressions of these molecules also significantly reduced this xenocytotoxicity despite the low levels of expression of either decoy Fas or membrane bound FasL . ^^^ CONCLUSION : These findings indicate that the strong xenocytotoxicity of human CD 8 ( + ) CTL is mediated mainly by the Fas / FasL pathway . ^^^ The overexpression of either decoy Fas or membrane bound FasL were quite effective in preventing CTL killing . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In addition , EPO reduced the mRNA level of TNF alpha , Fas and Fas L , as well as the activities of caspase 8 , 9 and 3 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / FasL , PD ECGF and PCNA were examined by immunohistochemistry and apoptotic tumor cells were detected by in situ TUNEL method . ^^^ The expression rates of Fas and FasL in group one and group three were 66 . 7 % ( 12 / 18 ) and 50 % ( 9 / 18 ) , 43 . 8 % ( 7 / 16 ) and 81 . 3 % ( 13 / 16 ) , 45 . 0 % ( 9 / 20 ) and 85 % ( 17 / 20 ) , respectively . ^^^ The 0 . 5 , 1 , 2 , 3 year survival rates were 96 % , 73 % , 60 % , 48 % , respectively , which were related with T , N , M and Fas expression , but not with PD ECGF and FasL expression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We analyzed the amount and phenotype of tumor infiltrating lymphocytes ( TIL ) and the expression of the apoptosis inducing molecule Fas and its ligand , FasL , on tumor cells and TIL in a selected series of UMM with the aim to establish if a correlation between their expression and the clinical behavior of UMM exists . ^^^ TIL phenotype and Fas / FasL expression were evaluated by immunohistochemistry in 61 cases of formalin fixed , paraffin embedded UMM . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
BACKGROUND : Fas ( CD95 / Apo 1 ) ligand ( FasL ) induced apoptosis in Fas bearing cells is critically involved in modulating immune reactions and tissue repair . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
AIM : To study the effects of interleukin 10 ( IL 10 ) on the expression of alpha smooth muscle actin ( alpha SMA ) , nuclear factor kappa B ( NF kappa B ) and Fas / Fas ligand ( FasL ) in hepatic stellate cells of experimental rats with hepatic fibrosis . ^^^ The expression of Fas and FasL mRNA was measured by RT PCR . ^^^ The mRNA of Fas and FasL in group C was significantly increased in a time dependent manner compared to that in control group . ^^^ After treated with IL 10 , the expression level of Fas and FasL was higher in group 1 than in group C . ^^^ The expression of Fas and FasL is increased in the course of liver fibrosis , and is further increased by IL 10 . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
At the same time Fas and FasL levels were inhibited upon treatment with beta lapachone in a concentration dependent manner . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The decrease of Fas was significant in the 13 week old varicocele group , whereas that of FasL was significant in the 11 week old varicocele group . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas and FasL mRNA expression was not regulated by estradiol . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
OxLDL induced the expression of Fas and FasL , and the subsequent caspase 8 cleavage and treatment with a neutralizing ZB 4 anti Fas antibody blocked apoptosis induced by OxLDL . ^^^ A 20 expression significantly attenuated the increased expression of Fas and FasL , and Fas mediated apoptosis . ^^^ These findings suggest that A 20 mediated protection from OxLDL may occur at the level of Fas / FADD caspase 8 and be FasL dependent . ^^^ Thus , A 20 expression blocks OxLDL mediated apoptosis in murine RAW264 . 7 macrophages through disrupting Fas / FasL dependent activation of caspase 8 and the mitochondria pathway . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Here we report that apoptotic cell death of PTEN deficient LNCaP and PC 3 prostate cancer cells induced by the PI3K inhibitor LY 294002 can be abrogated by disrupting Fas / Fas ligand ( FasL ) interactions with recombinant Fas : Fc fusion protein or FasL neutralizing antibody ( Nok 1 ) , or by expressing dominant negative Fas associated death domain . ^^^ Furthermore , we find that apoptosis induced by expression of wild type PTEN , driven by a tetracycline inducible expression system in LNCaP cells , can be inhibited by blocking Fas / FasL interaction using Fas : Fc or Nok 1 . ^^^ These data show that apoptosis induced by blockade of the PI3K pathway in prostate tumor cells is mediated by an autocrine Fas / FasL apoptotic mechanism and the Fas apoptotic pathway is both necessary and sufficient to mediate apoptosis by PI3K inhibition . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The induced apoptosis was associated with an increase in Fas and Fas L production . ^^^ In conclusion , Nell 1 overexpression can induce craniofacial anomalies associated with neural tube defects during embryonic development and may involve mechanisms of massive apoptosis associated with the Fas / Fas L signaling pathway . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Association of a microsatellite in FASL to type 2 diabetes and of the FAS 670G > A genotype to insulin resistance . ^^^ High glucose concentrations induce IL 1beta production in human beta cells , Fas expression and concomitant apoptosis owing to a constitutive expression of FasL . ^^^ FASL and FAS map to loci linked to type 2 diabetes and estimates of insulin resistance , respectively . ^^^ We have tested two functional promoter polymorphisms , FAS 670 G > A and FASL 844C > T as well as a microsatellite in the 3 ' UTR of FASL for association to type 2 diabetes in 549 type 2 diabetic patients and 525 normal glucose tolerant ( NGT ) control subjects . ^^^ We conclude that polymorphisms of FASL and FAS associate with type 2 diabetes and estimates of insulin resistance in Danish white subjects . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas , FasL , and soluble Fas mRNA in endomyocardial biopsies of human cardiac allografts . ^^^ Apoptosis mediated by the Fas / Fas ligand ( FasL ) has been implicated in rejection of solid organ allografts and it has been recently proposed that soluble forms of Fas could interfere with this interaction , blocking apoptosis . ^^^ The purpose of this study was to analyze intragraft Fas , FasL , and soluble Fas mRNA levels in relation to acute rejection in cardiac allografts in humans . mRNA levels were determined by quantitative reverse transcriptase polymerase chain reaction in 42 samples of endomyocardial biopsies obtained from 18 cardiac transplant recipients within the first 6 months after transplantation . ^^^ FasL and Fas mRNA levels were higher in biopsies with rejection than in biopsies without rejection , and no difference was observed in soluble Fas mRNA . ^^^ During rejection , there was a positive correlation between the mRNA levels of Fas FasL , Fas soluble Fas , and FasL soluble Fas . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
In this study , we show that stimulation of the Fas receptor by its ligand ( FasL ) induces rapid phosphorylation of Akt / PKB and a parallel increase in cell apoptosis in epidermal Cl 41 cells . ^^^ Treatment of the cells with pharmacological inhibitors of PI3K , wortmannin and 2 ( 4 morpholinyl ) 8 phenyl 4H 1 benzopyran 4 1 ( LY 294002 ) , similarly inhibits FasL induced apoptosis and Akt / PKB phosphorylation , indicating that PI3K is an upstream mediator of Akt / PKB and is involved in Fas mediated cell death . ^^^ Reporter gene and mRNA expression assays show that FasL activates fas transcriptional activity and this effect is inhibited by PI3K / Akt suppression . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The purpose of the present study was to analyse the effects of naltrexone on the expression levels of proteins regulating the extrinsic ( FasL and Fas ) and the mitochondrial ( Bcl 2 , Bcl xL , Bad and Bax ) apoptotic pathways , as well as the active fragment of the executioner caspase 3 in the mouse brain . ^^^ Western blotting showed that a single injection of naltrexone ( 1 mg / kg ) induced a down regulation of the pro apototic proteins Fas , FasL , Bad and Bax . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
We examined Fas expression and FasL induced apoptosis in human VSMCs in response to IFN gamma . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
This is attributed to the ability of IVIg to decrease the adhesion of T cells onto neurons , possibly through an effect on LFA 1 , and by lowering the levels of Fas and FasL on T cells . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Abnormal Fas / FasL and caspase 3 mediated apoptotic signaling pathways of T lymphocyte subset in patients with systemic lupus erythematosus . ^^^ OBJECTIVES : To explore the relationships between Fas FasL mediated signaling pathway and apoptosis disturbance of T lymphocyte subset in patients with SLE . ^^^ Cell surface expression rates of Fas , FasL , and intracellular expression rates of activated caspase 3 were evaluated by two color flow cytometry analysis in peripheral T lymphocyte subsets of SLE patients with inactive disease ( n=22 ) and with active disease ( n=17 ) . ^^^ The percentages of CD 4 ( + ) T cells expressing Fas ( P=0 . 023 , vs . control ) and FasL ( P=0 . 001 , vs . control ) were increased in patients with active disease . ^^^ But there were no obvious differences of expression rates of Fas and FasL on T cell subset between two disease groups ( P > 0 . 05 ) . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The aim of this study was to examine the expression patterns of apoptosis related antigens , such as Fas , FasL , and cFLIP , in cervical squamous cells , and investigate the role of Fas mediated apoptosis in the pathogenesis of cervical neoplasia . ^^^ Using specific antibodies for Fas , FasL , and cFLIP , we examined protein expression in 19 specimens of normal cervix , 15 mild dysplasia ( CIN 1 ) , 22 moderate dysplasia ( CIN 2 ) , 23 severe dysplasia ( CIN 3 ) , and 34 invasive squamous cell carcinoma ( SCC ) by immunohistochemistry . ^^^ Deregulated Fas / FasL system and constitutive expression of cFLIP in SCC may be an important mechanism by which SCCs escape apoptosis during the malignant transformation and progression of these tumors . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
A dual altered peptide ligand down regulates myasthenogenic T cell responses and reverses experimental autoimmune myasthenia gravis via up regulation of Fas FasL mediated apoptosis . ^^^ The aims of this study were to investigate the possible role of Fas FasL mediated apoptosis in the down regulatory mechanism of the dual APL . ^^^ We demonstrate here the effect of the dual APL on expression of key molecules involved in the Fas FasL pathway , in a p 195 212 specific T cell line , in mice immunized with Torpedo acetylcholine receptor and in mice afflicted with EAMG ( induced with the latter ) . ^^^ In vitro and in vivo results show that the dual APL up regulated expression of Fas and FasL on the CD 4 cells . ^^^ Results strongly indicate that up regulation of apoptosis via the Fas FasL pathway is one of the mechanisms by which the dual APL reverses EAMG manifestations in C57BL / 6 mice . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
FasL ) , a paradigmatic ' trans signal converter protein ( TSCP ) ' , can attach to APC ( via CTLA 4 binding to B 7 ) and direct intercellular inhibitory signals to responding T cells ( via FasL binding to Fas receptor ) , converting an activating APC to T cell signal into an inhibitory one . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Apoptosis of OSNs was identified using immunohistochemistry for caspase 3 expression , electron microscopy for ultrastructural cellular morphology , and real time polymerase chain reaction for elevated expression of the proapoptotic genes Fas , FasL , p75NGFR , p 53 , Bax , caspase 3 , and CAD . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
The infiltrates consisted almost exclusively of T lymphocytes that were minimally activated , with a minimal increase in the expression of CD 69 and no changes in the expression of CD 25 , Fas , FasL , or CD40L . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Treatment with poly 1 : C also induced expression of NKG2D , granzyme B , perforin , Fas L , TRAIL , and IFN gamma on liver lymphocytes , which were delayed or reduced in ethanol treated mice compared with pair fed mice . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Fas / FasL signaling allows extracelluar signal regulated kinase to regulate cytochrome c release in oridonin induced apoptotic U 937 cells . ^^^ Western blot analysis showed the up regulated expression of Fas , FasL , and FADD , and down regulated expression of procaspase 8 , suggesting that Fas / FasL pathway was activated in oridonin induced cell apoptosis . ^^^ Taken together , these results suggest that Fas / FasL signaling pathway mediated ERK activation sensitized U 937 cells to mitochondrial pathway mediated apoptosis induced by oridonin . . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
Expression of Fas and Fas L in renal cell carcinoma ] . ^^^ INTRODUCTION : The previous investigations revealed that Fas L expression on tumor cells can be one of the reasons of tumor growth , or tumor regression , with or without activation of the immune response . ^^^ OBJECTIVE : The objective of our study was to investigate the expression of Fas and Fas L in situ in normal human renal tissue as well as in different types of renal cell carcinoma ( RCC ) according to tumor grading . ^^^ METHOD : Expression of Fas and Fas L was examined in 25 RCCs classified according to nuclear grades : G 1 G3 and to cell type : 17 clear cells , 3 chromophilics ( 2 eosinophilics , 1 basophilic ) , 2 chromophobes and 3 spindle cells . ^^^ Spread and intensity of staining of Fas and Fas L molecules expression were scored semiquantitatively . ^^^
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA
Interacting proteins: P48023 and P25445	Pubmed	SVM Score :0.0
NA