| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.75712013 |
| The recently identified decoy receptor 3 ( DcR 3 ) binds to FasL and inhibits FasL induced apoptosis , and is considered to play a role in the immune escape system of neoplastic cells . 0.75712013^^^ |
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| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :1.2862237 |
| Here , we demonstrate that TR 6 specifically binds two cellular ligands , LIGHT ( herpes virus entry mediator ( HVEM ) L ) and Fas ligand ( FasL / CD95L ) . 1.2862237^^^ |
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| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :1.2475928 |
| Human TR 6 was also shown to cross react with membrane bound mouse FasL , since the in vitro cytotoxic activity of L 929 cells transfected with murine FasL was inhibited in the presence of human TR 6 . 1.2475928^^^ |
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| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| Here we report the discovery of a soluble decoy receptor , termed decoy receptor 3 ( DcR 3 ) , that binds to FasL and inhibits FasL induced apoptosis . ^^^ |
|
| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| Recently , a soluble decoy receptor , termed decoy receptor 3 ( DcR 3 ) , that binds FasL and inhibits FasL induced apoptosis , has been identified . ^^^ |
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| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| This Fas resistance did not correlated with high levels of mRNA either for DcR 3 , a decoy receptor for FasL , or for FAP 1 , a Fas associated phosphatase that can block the apoptotic function of Fas . ^^^ |
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| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| Decoy receptor 3 ( DcR 3 ) is a newly identified soluble protein that binds to CD 95 ligand ( CD95L ) and inhibits its proapoptotic activity . ^^^ We also demonstrate that human malignant glioma cells engineered to release high amounts of DcR 3 into the cell culture supernatant are protected from CD95L induced apoptotic cell death . ^^^ Chemotaxis assays revealed that DcR 3 counteracts the chemotactic activity of CD95L against microglial cells in vitro . ^^^ |
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| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Decoy receptor 3 ( DcR 3 ) , a nonfunctional receptor that binds to Fas ligand ( FasL ) , was constitutively expressed at high level in keratinocytes but decreased rapidly in cells exposed to UVB . ^^^ |
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| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| It was recently reported that there is a soluble decoy receptor ( DcR 3 ) , which binds to FasL and inhibits FasL induced apoptosis , and certain tumors may escape FasL dependent immune cytotoxic attack by expressing a decoy receptor that blocks FasL . ^^^ CONCLUSION : The DcR 3 decoy receptor for FasL may be involved in the progression of gastric cancer . ^^^ The prognostic significance of overexpression of the decoy receptor for Fas ligand ( DcR 3 ) in patients with gastric carcinomas . ^^^ |
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| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| Decoy receptor 3 ( DcR 3 ) is a novel member of the TNF receptor superfamily , which binds to and blocks the activities of the ligands FasL and LIGHT . ^^^ While retaining its ability to bind LIGHT and inhibit LIGHT mediated activities , DcR 3 ( 1 218 ) no longer bound FasL and did not inhibit FasL mediated apoptosis in vitro . ^^^ As a result , the modification in the sequence of DcR 3 to produce FLINT ( LY 498919 ) should result in a pharmacologically superior molecule in the therapeutic intervention of diseases in which the pathogenesis is linked to FasL mediated apoptotic or inflammatory events . . ^^^ Decoy receptor 3 ( DcR 3 ) is proteolytically processed to a metabolic fragment having differential activities against Fas ligand and LIGHT . ^^^ |
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| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| Decoy receptor 3 ( DcR 3 ) is a novel member of the tumor necrosis factor receptor superfamily , which binds to and blocks the activities of the ligands , FasL and LIGHT ( a cellular ligand for herpes virus entry mediator and lymphotoxin receptor ) , that play an important role in regulating apoptosis in normal physiology . ^^^ |
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| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| The effects of Fas ligand are modulated by factors in lung fluids , such as cytokines ( e . g . , transforming growth factor beta , surfactant protein A , and angiotensin 2 ) and a specific Fas ligand decoy receptor ( DcR 3 ) . ^^^ |
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| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| DcR 3 is a soluble receptor against Fas ligand belonging to the tumor necrosis factor receptor superfamily and overexpresses in some forms of cancers . ^^^ |
|
| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| Pretreatment with a FasL antagonist , a decoy receptor 3 analogue ( DcR 3 analogue ) , reduced neutrophil infiltration into the airspace and resulted in a highly significant reduction in the levels of GM CSF , MIP 2 and KC in bronchoalveolar lavage ( BAL ) fluid . ^^^ |
|
| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| Decoy receptor 3 ( DcR 3 ) , a newly identified soluble protein belonging to the tumor necrosis factor receptor ( TNFR ) superfamily , is a receptor for Fas ligand ( FasL ) , LIGHT and TL1A . ^^^ |
|
| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| A soluble decoy receptor , DcR 3 , belongs to the tumor necrosis factor receptor ( TNFR ) family , and this receptor is known to bind to three TNF family ligands , namely Fas ligand ( FasL ) , LIGHT , and TL1A . ^^^ |
|
| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| The newly identified tumor secreted soluble decoy receptor 3 ( DcR 3 ) can bind to the ligands CD95L and LIGHT , thereby neutralizing their pro apoptotic actions . ^^^ |
|
| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| Decoy receptor 3 ( DcR 3 ) / TR6 / M68 is a soluble receptor that binds to the Fas ligand LIGHT and TL1A . ^^^ |
|
| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| FasL is inhibited by decoy receptor 3 ( DcR 3 ) , a naturally occurring decoy receptor . ^^^ We determined the effects of systemic blockade of the Fas / FasL system by a DcR 3 analog ( DcR 3 a ) in mice with pneumococcal pneumonia . ^^^ CONCLUSION : Blockade of the Fas / FasL system by DcR 3 a in the lungs improves clearance of bacteria in mice with pneumococcal pneumonia . . ^^^ |
|
| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| Decoy receptor 3 ( DcR 3 ) , a soluble receptor for FasL , LIGHT and TL1A , is highly expressed in cancer cells . ^^^ |
|
| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| Decoy receptor 3 ( DcR 3 ) , a soluble receptor in the tumor necrosis factor ( TNF ) receptor family , is known to inhibit apoptosis mediated by pro apoptotic TNF family cytokines such as Fas ligand ( FasL ) , TL1A , and LIGHT . ^^^ |
|
| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| We therefore investigated the expression of Fas , FasL and Decoy receptor 3 for FasL ( DcR 3 ) in UC specimens and cell lines , and examined the cytotoxic effect of an anti Fas activating monoclonal antibody ( mAb ) in vitro . ^^^ |
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| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| Primary hepatoma cell culture and MTT test were used to evaluate the protection against FasL and chemical induced apoptosis by DcR 3 expression . ^^^ DcR 3 expression could be protect hepatoma cells against apoptosis induced by FasL , but not by chemicals . ^^^ |
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| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| Decoy receptor 3 ( DcR 3 ) , a soluble receptor for Fas ligand , LIGHT ( homologous to lymphotoxins shows inducible expression and competes with HSV glycoprotein D for herpes virus entry mediator , a receptor expressed by T lymphocytes ) , and TNF like molecule 1A , is highly expressed in cancer cells and in tissues affected by autoimmune disease . ^^^ Decoy receptor 3 ( DcR 3 ) , a soluble receptor for Fas ligand , LIGHT ( homologous to lymphotoxins shows inducible expression and competes with HSV glycoprotein D for herpes virus entry mediator , a receptor expressed by T lymphocytes ) , and TNF like molecule 1A , is highly expressed in cancer cells and in tissues affected by autoimmune disease . ^^^ |
|
| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| TR 6 can bind to FasL and prevent FasL induced apoptosis ; it can also associate with LIGHT , another TNF family member . ^^^ |
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| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| TR 6 can interfere with FasL or LTbetaR mediated apoptosis ; it can also inhibit T cell costimulation by blocking the two way signaling between TR 2 and LIGHT , and the one way signaling from TL1A to DR 3 . ^^^ |
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| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| Functional study showed that insulin release was compromised after FasL and IFN gamma treatment , and the compromise could be prevented with TR 6 Fc . ^^^ This indicates that TR 6 indeed protected beta cells from damage caused by FasL and IFN gamma . ^^^ |
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| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| Solid phase TR 6 can trigger reverse signaling of LIGHT and FasL expressed on T cells , and lead to T cell costimulation . ^^^ |
|
| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95407 and P48023 |
Pubmed |
SVM Score :0.0 |
| NA |
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