| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| However , Jagged 2 and Notch 1 are coexpressed in the apical ectodermal ridge ( AER ) , suggesting a role for this ligand receptor pair in limb development . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| Isolation and functional analysis of a cDNA for human Jagged 2 , a gene encoding a ligand for the Notch 1 receptor . ^^^ Immunohistochemistry revealed coexpression of Jagged 2 and Notch 1 within thymus and other fetal murine tissues , consistent with interaction of the two proteins in vivo . ^^^ Coculture of fibroblasts expressing human Jagged 2 with murine C2C12 myoblasts inhibited myogenic differentiation , accompanied by increased Notch 1 and the appearance of a novel 115 kDa Notch 1 fragment . ^^^ Constitutively active forms of Notchl in C2C12 cells also induced increased levels of the same set of mRNAs , suggesting positive feedback control of these genes initiated by binding of Jagged 2 to Notch 1 . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| To examine whether this signaling pathway may play a similar role in the development of the hair cell mosaic in the mammalian vestibular system , the expression patterns of proneural ( Math 1 ) and neurogenic ( Notch 1 , Jagged 2 , HES 5 ) genes were examined in the developing mouse inner ear . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| Delta 1 , Jagged 1 , and Jagged 2 , commonly designated Delta / Serrate / LAG 2 ( DSL ) proteins , are known to be ligands for Notch 1 . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| Physical interaction of Delta 1 , Jagged 1 , and Jagged 2 with Notch 1 and Notch 3 receptors . ^^^ Taken together , these results suggest that Delta 1 , Jagged 1 , and Jagged 2 are ligands for Notch 1 and Notch 3 receptors . . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| To determine the presence of these genes during vascular response to injury , we analyzed expression of Jagged 1 , Jagged 2 , and Notch 1 through 4 after balloon catheter denudation of the rat carotid artery . ^^^ Although low levels of Jagged 1 , Jagged 2 , and constitutive expression of Notch 1 were seen in uninjured endothelium , expression of all was significantly increased in injured vascular cells . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| Here , we report that Notch 1 , Notch 3 , Notch 4 , Delta 4 , Jagged 1 and Jagged 2 are all expressed in arteries , but are not expressed by veins . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis revealed the expression of three Notch receptors ( Notch 1 , Notch 2 , and Notch 3 ) , Notch ligands ( Jagged 1 , Jagged 2 , and Delta 1 ) , and presenilin 1 ( PS 1 ) in neonatal mouse testis . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| We report intricate expression patterns for the Notch 1 receptor and three ligands , Delta 1 , Jagged 1 and Jagged 2 in the hair follicle . ^^^ Expression of Jagged 1 or Jagged 2 overlaps Notch 1 expression at all stages . ^^^ In the follicle bulb , Jagged 2 is localised to the inner ( basal ) bulb cells next to the dermal papilla which do not express Notch 1 , whereas Jagged 1 expression in the upper follicle bulb overlaps Notch 1 expression and correlates with bulb cell differentiation into hair shaft cortical and cuticle keratinocytes . . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| In addition , we observed endogenous Notch 1 expression on the surface of both HL 60 cells and primary CD 34 ( + ) cells , and therefore exposed cells to Notch ligand Jagged 2 , expressed on NIH3T3 cells . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| The Notch signaling components shows both distinct and overlapping expression patterns of Notch 1 receptor and its ligands Jagged 1 ( Jag 1 ) and Jagged 2 ( Jag 2 ) in the developing auditory epithelium of the rat . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| We found that TNF induced the expression of Notch 1 , Notch 4 , and Jagged 2 in RSF . ^^^ Notch 1 , Notch 4 , and Jagged 2 proteins were also detected in the developing synovium of mouse embryo . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| The FGF 10 positive pancreatic cells expressed Notch 1 and Notch 2 , the Notch ligand genes Jagged 1 and Jagged 2 , as well as the Notch target gene Hes 1 . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| Expression of Notch 1 , Jagged 1 , and Jagged 2 frequently overlapped , whereas Notch 2 expression was restricted to specific crypt cells , the lamina propria of the large intestine , and Peyer ' s patch lymphocytes . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| Requirement of Notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes . ^^^ Recently , it has been revealed that this signaling system is expressed in the mammalian testis by showing coexpression of Jagged 2 and its receptor , Notch 1 , is consistent with Notch 1 being a cognate receptor for Jagged 2 in the mammalian testis . ^^^ Therefore , we investigated expressions of messenger RNAs of Notch 1 and Jagged 2 in the testicular tissues of developing Sprague Dawley rats by reverse transcription polymerase chain reaction and Northern blot analysis , expressions of their proteins in the testicular tissues of developing rats , fertile human controls and infertile human patients with maturation arrest by immunohistochemistry , and effects of antibodies to this system by culturing rat testicular tissues with these antibodies . ^^^ Transcripts of Notch 1 and Jagged 2 in the rat testis were positive throughout the examined period ; these intensities became higher at day 13 after birth , coincidence with the formation of spermatocytes , and peaked at day 19 after birth . ^^^ Expressions of Notch 1 and Jagged 2 were recognized at first in the perinuclear regions of spermatocytes in the rat testis as a round structure at day 19 after birth and thereafter in further differentiated germ cells as meiosis proceeded . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| The Notch ligands , including Delta like 1 and 3 and Jagged 1 and Jagged 2 , show distinct expression patterns in the developing and adult brain overlapping that of Notch 1 . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| Expression of Notch 1 and Jagged 2 in the enteric nervous system . ^^^ To explore the involvement of the Notch pathway in neuronal cells of adult rat gut , we investigated the expression of Notch 1 and Jagged 2 by in situ hybridization ( ISH ) and immunohistochemistry ( IHC ) . ^^^ In the enteric nervous system , Notch 1 and Jagged 2 were expressed in ganglia of the submucosal and myenteric plexus . ^^^ Notch 1 was preferentially expressed in cholinergic neurons lacking calretinin or nitric oxide synthase ( NOS ) , whereas Jagged 2 was present in most neuron subtypes . ^^^ We propose that Notch 1 and Jagged 2 have a continuing role in the maintenance and function of neuronal cells in the adult enteric nervous system . . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| Expression is first detected in the circumvallate papilla at embryonic day E14 . 5 , when Notch 1 , Jagged 1 , and Jagged 2 are expressed broadly in the papilla and general lingual epithelium . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| Based on the role of the Notch / Delta / Jagged system in cell fate specification and recent reports linking Notch signaling with normal bile duct formation in mouse and human liver , we examined the expression of Notch 1 , Notch 2 , Notch 3 , Delta 1 , Delta 3 , Jagged 1 , and Jagged 2 , and delta like protein / preadipocyte factor 1 / fetal antigen 1 ( dlk ) in four well defined experimental rat models of liver injury and regeneration . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| To begin to determine whether Cux 1 regulation by the Notch signaling pathway is conserved in mammals , we compared the expression patterns of Cux 1 , the murine Notch receptors ( Notch 1 4 ) , and the murine ligands ( Jagged 1 , Jagged 2 , and Delta 1 ) during murine embryogenesis and kidney development . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| Jagged 2 CHO and Delta 4 CHO cells transfected with the Notch ligands Jagged 2 and Delta 4 , respectively , were incubated with Notch 1 32D cells to observed inhibition of Notch on G CSF induced differentiation . ^^^ Compared with other Notch ligands , Delta 4 was slightly weaker than Jagged 2 , but stronger than Delta 1 and Jagged 1 in terms of Notch 1 ligands . ^^^ Jagged 2 could inhibit Notch 1 32D cell differentiation induced by G CSF , but Delta 4 could not . ^^^ Jagged 2 can inhibit Notch 1 32D cell differentiation induced by G CSF , but Delta 4 cannot . . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| METHODS : By performing comparative histology for adult and embryonic pancreatic markers in caerulein treated and control pancreas , we addressed cellular proliferation and differentiation ( amylase , DBA agglutinin , insulin , glucagon , beta catenin , E cadherin , Pdx 1 , Nkx6 . 1 , Notch 1 , Notch 2 , Jagged 1 , Jagged 2 , Hes 1 ) , hereby describing the kinetics of tissue restoration . ^^^ RESULTS : We demonstrate that surviving pancreatic exocrine cells repress the terminal exocrine gene program and induce genes normally associated with undifferentiated pancreatic progenitor cells such as Pdx 1 , E cadherin , beta catenin , and Notch components , including Notch 1 , Notch 2 , and Jagged 2 . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| The bile duct like differentiation of hepatocytes was associated with increased expression of Jagged 1 , Jagged 2 , Notch 1 , and several Notch target genes . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| Remarkably , unlike the case of APP , CTFs derived from Notch 1 , Jagged 2 , deleted in colorectal cancer ( DCC ) , and N cadherin remain largely detergent soluble , indicative of their spatial segregation in non raft domains . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| Notch 1 and 2 cooperate in limb ectoderm to receive an early Jagged 2 signal regulating interdigital apoptosis . ^^^ Our results confirm that Jagged 2 loss describes the contribution of the entire Notch pathway to the mouse limb development and revealed that both Notch 1 and 2 are required in the ectoderm to receive the Jagged 2 signal . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| Here , we have investigated , for the first time , the expression of Notch 1 , Notch 2 , Jagged 1 , Jagged 2 and Delta like 1 proteins , by immunohistochemistry , in a series of benign and malignant human melanocytic lesions : five common melanocytic nevi , five ' dysplastic nevi ' and 20 melanomas ( five in situ , five T 1 T2 , five T 3 T4 and five metastatic melanomas ) . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| Loss of function studies implicating the neurogenic genes Notch 1 , Jag 2 , Hes 1 and Hes 5 generated a significant increase in the number of hair cells . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| Further , the induction of IL 6 secretion was blocked in vitro by interference with anti Notch 1 monoclonal antibodies raised against the binding sequence of Notch 1 with JAG 2 . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| Here , we report on the expression pattern of Notch 1 4 , Jagged 1 ( Jag 1 ) , Jag 2 , Delta like 1 ( Dll 1 ) , Dll 3 , Dll 4 , Rbpsuh , Deltex 1 ( Dtx 1 ) and Dtx 2 genes during preimplantation development from unfertilized eggs until late blastocyst stage using a RT PCR strategy . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| Jag 2 Notch 1 signaling regulates oral epithelial differentiation and palate development . ^^^ In this report , we show that Jag 2 is expressed throughout the oral epithelium and is required for Notch 1 activation during oral epithelial differentiation . ^^^ Oral periderm activation of Notch 1 is significantly attenuated during palate development in the Jag 2 mutants . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| Notch 1 signals through Jagged 2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud . ^^^ We demonstrate that Notch signalling , involving Notch 1 and Jagged 2 , is required to regulate the number of Fgf 8 expressing cells that comprise the AER and that regulation of the levels of fibroblast growth factor signalling is important for the freeing of the digits during normal limb formation . ^^^ |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y219 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|