Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q92585 and P46531	Pubmed	SVM Score :0.0
Second , a 62 amino acid peptide derived from a NOTCH coactivator , Mastermind like 1 ( MAML 1 ) , forms a transcriptionally inert nuclear complex with NOTCH 1 and CSL and specifically inhibits the growth of both murine and human NOTCH 1 transformed T ALLs . ^^^
Interacting proteins: Q92585 and P46531	Pubmed	SVM Score :0.0
There seems to be close correlation of the spatial and temporal expression among Maml 1 , Notch 1 and Hes 1 in the central nervous system ( CNS ) during early development , implicating a role for the Maml 1 gene in neurogenesis . . ^^^
Interacting proteins: Q92585 and P46531	Pubmed	SVM Score :0.0
To investigate the function of MAMLs in hematopoietic development , we introduced a dominant negative ( DN ) mutant of MAML 1 , capable of inhibiting Notch 1 4 , in murine hematopoietic stem cells . ^^^
Interacting proteins: Q92585 and P46531	Pubmed	SVM Score :0.0
We report here the crystal structure of a Notch transcriptional activation complex containing the ankyrin domain of human Notch 1 ( ANK ) , the transcription factor CSL on cognate DNA , and a polypeptide from the coactivator Mastermind like 1 ( MAML 1 ) . ^^^
Interacting proteins: Q92585 and P46531	Pubmed	SVM Score :0.0
Inhibition of endothelial cell proliferation by Notch 1 signaling is mediated by repressing MAPK and PI3K / Akt pathways and requires MAML 1 . ^^^ Overexpression of a dominant negative mutant of MAML 1 antagonized the effects of activated Notch 1 on the MAPK and PI3K / Akt pathways . ^^^
Interacting proteins: Q92585 and P46531	Pubmed	SVM Score :0.0
We show here that the mutation of the S 4 sequence leads to hypophosphorylation of ICN 1 ; increased NOTCH 1 signaling ; and the stabilization of complexes containing ICN 1 , CSL , and MAML 1 . ^^^
Interacting proteins: Q92585 and P46531	Pubmed	SVM Score :0.0
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Interacting proteins: Q92585 and P46531	Pubmed	SVM Score :0.0
NA