| Interacting proteins: Q8NES3 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8NES3 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8NES3 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8NES3 and P46531 |
Pubmed |
SVM Score :0.0 |
| The Dll 1 , Notch 1 and RBPJkappa mutations disrupt the expression of Lunatic fringe ( L fng ) , Jagged 1 , Mesp 1 , Mesp 2 and Hes 5 in the PSM . ^^^ |
|
| Interacting proteins: Q8NES3 and P46531 |
Pubmed |
SVM Score :0.0 |
| Expression of Dll 1 , Dll 3 , Lfng and Notch 1 is altered in rv mutant embryos , and rv and Dll 1 ( lacZ ) , a null allele of the Notch ligand Delta 1 , genetically interact . ^^^ |
|
| Interacting proteins: Q8NES3 and P46531 |
Pubmed |
SVM Score :0.0 |
| Using a cell co culture assay , we find that mammalian Lunatic fringe ( Lfng ) inhibits Jagged 1 mediated signalling and potentiates Delta 1 mediated signalling through Notch 1 . ^^^ Lfng does not prevent binding of soluble Jagged 1 or Delta 1 to Notch 1 expressing cells . ^^^ Lfng potentiates both Jagged 1 and Delta 1 mediated signalling via Notch 2 , in contrast to its actions with Notch 1 . ^^^ |
|
| Interacting proteins: Q8NES3 and P46531 |
Pubmed |
SVM Score :0.0 |
| In Psen 1 deficient mice , proteolytic activation of Notch 1 was significantly affected and the expression of several genes involved in the Notch signalling pathway was altered , including Delta like 3 , Hes 5 , lunatic fringe ( Lfng ) and Mesp 2 . ^^^ |
|
| Interacting proteins: Q8NES3 and P46531 |
Pubmed |
SVM Score :0.0 |
| Analysis of compound homozygotes shows that Foxc 1 and Foxc 2 are both required for transcription in the anterior presomitic mesoderm of paraxis , Mesp 1 , Mesp 2 , Hes 5 , and Notch 1 , and for the formation of sharp boundaries of Dll 1 , Lfng , and ephrinB 2 expression . ^^^ |
|
| Interacting proteins: Q8NES3 and P46531 |
Pubmed |
SVM Score :0.0 |
| Here we show that distinct segmentation defects are displayed in embryos mutant for the Notch pathway genes Notch 1 , Lunatic fringe ( Lfng ) , Delta like 1 ( Dll 1 ) , and Delta like 3 ( Dll 3 ) . ^^^ |
|
| Interacting proteins: Q8NES3 and P46531 |
Pubmed |
SVM Score :0.0 |
| Here , we report that expression of mammalian fringe proteins ( Lunatic [ LFng ] , Manic [ MFng ] , or Radical [ RFng ] Fringe ) increased Delta 1 binding and activation of Notch 1 signaling in 293T and NIH 3T3 cells . ^^^ |
|
| Interacting proteins: Q8NES3 and P46531 |
Pubmed |
SVM Score :0.0 |
| Here we show that developmental stage specific expression of the glycosyltransferase lunatic fringe ( Lfng ) is required for coordination of the access of T cell progenitors to intrathymic niches that support Notch 1 dependent phases of T cell development . ^^^ We suggest that the ability of Lfng and Notch 1 to control progenitor competition for limiting cortical niches is an important mechanism for the homeostatic regulation of thymus size . . ^^^ |
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