| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| The human homolog of rat Jagged 1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch 1 . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| We examined the expression of two members of the Notch family , Notch 1 and Notch 2 , and one Notch ligand , Jagged 1 , in hematopoietic cells . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Oligodendrocytes and their precursors in the developing rat optic nerve express Notch 1 receptors and , at the same time , retinal ganglion cells express Jagged 1 , a ligand of the Notch 1 receptor , along their axons . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| We found that Notch 1 , Notch 2 , and a Notch ligand , Jagged 1 , are expressed in adult brain in mouse and in human , with strongest expression in the hippocampal formation and Purkinje cells of the cerebellum . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| We examined the spatio temporal expression of genes in the Notch signaling pathway , Notch receptors ( Notch 1 4 ) and two ligands , Jagged 1 and Delta 1 , in the developing mammalian inner ear . ^^^ Our results show that Notch 1 and Jagged 1 are first expressed in the otic vesicle , likely involved in differentiation of the VIIIth nerve ganglion neurons , and subsequently within the inner ear sensory epithelia , temporally coincident with initial hair cell differentiation . ^^^ Notch 1 expression is specific to hair cells and Jagged 1 to supporting cells . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| We report intricate expression patterns for the Notch 1 receptor and three ligands , Delta 1 , Jagged 1 and Jagged 2 in the hair follicle . ^^^ Expression of Jagged 1 or Jagged 2 overlaps Notch 1 expression at all stages . ^^^ In the follicle bulb , Jagged 2 is localised to the inner ( basal ) bulb cells next to the dermal papilla which do not express Notch 1 , whereas Jagged 1 expression in the upper follicle bulb overlaps Notch 1 expression and correlates with bulb cell differentiation into hair shaft cortical and cuticle keratinocytes . . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Three human disorders including a neoplasia ( a T cell acute lymphoblastic leukemia / lymphoma ) , a late onset neurological disease ( CADASIL ) and a developmental disorder ( the Alagille syndrome ) are associated with mutations in , respectively , the Notch 1 , Notch 3 and Jagged 1 genes , pointing out the broad spectrum of Notch activity in humans . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| The Dll 1 , Notch 1 and RBPJkappa mutations disrupt the expression of Lunatic fringe ( L fng ) , Jagged 1 , Mesp 1 , Mesp 2 and Hes 5 in the PSM . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| The cell surface receptor Notch 1 is expressed on CD34+ hematopoietic precursors , whereas one of its ligands , Jagged 1 , is expressed on bone marrow stromal cells . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Expression pattern of notch 1 , 2 and 3 and Jagged 1 and 2 in lymphoid and stromal thymus components : distinct ligand receptor interactions in intrathymic T cell development . ^^^ We report here that different Notch receptor ligand partnerships may occur inside the thymus , as we observed differential expression of Notch 1 , 2 and 3 receptors , their ligands Jagged 1 and 2 , and downstream intracellular effectors hairy and Enhancer of Split homolog 1 ( HES 1 ) and hairy and Enhancer of Split homolog 5 ( HES 5 ) , depending on ontogenetic stage and thymic cell populations . ^^^ Finally , Notch 3 was preferentially up regulated in thymocytes , following the induction of their differentiation by interaction with thymic epithelial cells expressing the cognate Jagged 1 and 2 ligands , suggesting that , besides Notch 1 , Notch 3 may also be involved in distinct steps of thymocyte development . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Finally , solid phase binding assay showed that Jagged 1 binds to Notch 1 and Notch 3 in addition to Notch 2 , suggesting that mJagged 1 is a ligand for multiple Notch receptors . . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| On the other hand , high levels of Delta 1 expressed in the N2a cells themselves stimulated neurite extension , increased numbers of primary neurites and induced expression of Jagged 1 and Notch 1 . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| We report here that Serrate 1 ( Jagged 1 ) , a ligand for the Notch 1 receptor , may contribute to the differentiation of peripheral CD 4 ( + ) T cells into either helper or regulatory cells . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| K 562 and HEL cells expressed the Notch 1 receptor and the Notch ligand Jagged 1 . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| MATERIALS : Described here is a single cell RT PCR analysis of Notch 1 , Notch 3 , Notch 4 , Notch ligands ( Dll 1 and Jagged 1 ) , and Fringe gene expression in cells of the blood system . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| The Notch signaling components shows both distinct and overlapping expression patterns of Notch 1 receptor and its ligands Jagged 1 ( Jag 1 ) and Jagged 2 ( Jag 2 ) in the developing auditory epithelium of the rat . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Fringe differentially modulates Jagged 1 and Delta 1 signalling through Notch 1 and Notch 2 . ^^^ Using a cell co culture assay , we find that mammalian Lunatic fringe ( Lfng ) inhibits Jagged 1 mediated signalling and potentiates Delta 1 mediated signalling through Notch 1 . ^^^ Lfng does not prevent binding of soluble Jagged 1 or Delta 1 to Notch 1 expressing cells . ^^^ Lfng potentiates both Jagged 1 and Delta 1 mediated signalling via Notch 2 , in contrast to its actions with Notch 1 . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Delta 1 , Jagged 1 , and Jagged 2 , commonly designated Delta / Serrate / LAG 2 ( DSL ) proteins , are known to be ligands for Notch 1 . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Physical interaction of Delta 1 , Jagged 1 , and Jagged 2 with Notch 1 and Notch 3 receptors . ^^^ Taken together , these results suggest that Delta 1 , Jagged 1 , and Jagged 2 are ligands for Notch 1 and Notch 3 receptors . . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Functionally , Delta 4 is indistinguishable from Jagged 1 in its abilities to inhibit myogenesis and to stimulate transcription through Notch 1 and the DNA binding protein CSL . . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| To determine the presence of these genes during vascular response to injury , we analyzed expression of Jagged 1 , Jagged 2 , and Notch 1 through 4 after balloon catheter denudation of the rat carotid artery . ^^^ Although low levels of Jagged 1 , Jagged 2 , and constitutive expression of Notch 1 were seen in uninjured endothelium , expression of all was significantly increased in injured vascular cells . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Here , we report that Notch 1 , Notch 3 , Notch 4 , Delta 4 , Jagged 1 and Jagged 2 are all expressed in arteries , but are not expressed by veins . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Expression of Notch 1 and Jagged 1 proteins in acute myeloid leukemia cells . ^^^ As the first step to clarify this , we examined the expression of Notch 1 and Jagged 1 proteins in eight AML cell lines and 15 fresh AML samples by immunoblotting . ^^^ In four cell lines and four fresh samples , both Notch 1 and Jagged 1 proteins were observed . ^^^ In these cells , Notch 1 and Jagged 1 proteins may interact among themselves . ^^^ We showed that Notch 1 and Jagged 1 proteins are widely expressed in AML cells . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| In addition , we found expression of Jagged 1 , one of the Notch 1 activators , in unmyelinated axons of the cerebellar ML during normal development . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| We demonstrate a novel mechanism for the oncogenic capacity of Notch 1 by showing that the interaction between intact Notch 1 on tumor cells and its ligand Jagged 1 dramatically induces proliferation and inhibition of apoptosis in vitro . ^^^ We further provide evidence that in Hodgkin and anaplastic large cell lymphoma , Jagged 1 is expressed in malignant and in bystander cells colocalizing with Notch 1 positive tumor cells . ^^^ Notch 1 signaling may therefore be activated in tumor cells by Jagged 1 through homotypic or heterotypic cell cell interactions , and it seems likely that these interactions contribute to lymphomagenesis in vivo . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| The Notch ligands , including Delta like 1 and 3 and Jagged 1 and Jagged 2 , show distinct expression patterns in the developing and adult brain overlapping that of Notch 1 . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Notch 1 and Jagged 1 expression by the developing pulmonary vasculature . ^^^ We performed a systematic evaluation of Notch1 / Jagged1 gene and protein expression in the developing mouse lung from embryonic day 11 until adulthood by using quantitative PCR , immunofluorescence , and electron microscopic analysis . mRNA transcripts for Notch 1 4 and Jagged 1 increased progressively from early to later lung development , accompanied by a simultaneous rise in endothelial cell specific gene expression , a pattern not seen in other organs . ^^^ Immunofluorescence staining revealed the progressive acquisition of Notch 1 and Jagged 1 proteins by the emerging endothelium . ^^^ Notch 1 and Jagged 1 were seen initially on well formed , larger vessels within the embryonic lung bud and progressively on finer vascular networks . ^^^ The localization of Notch 1 and Jagged 1 on endothelial cell surface membranes within the alveolar microvasculature was confirmed by immuno electron microscopy . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| During mammalian central nervous system ( CNS ) development , contact mediated activation of Notch 1 receptors on oligodendrocyte precursors by the ligand Jagged 1 induces Hes 5 , which inhibits maturation of these cells . ^^^ Within and around active MS plaques lacking remyelination , Jagged 1 was expressed at high levels by hypertrophic astrocytes , whereas Notch 1 and Hes 5 localized to cells with an immature oligodendrocyte phenotype , and TGF beta 1 was associated with perivascular extracellular matrix in the same areas . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| In the circle of Willis , peptide 19 ( PEP 19 ) , connexin 37 ( CXN 37 ) , growth arrest and DNA damage inducible gene ( GADD 45 ) , and the putative G protein coupled receptor RA1c , Notch 1 , and jagged 1 were predominantly expressed . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| To illustrate a role of Notch signaling in the determinant of the cell fate , we examined expression patterns of Notch 1 and Jagged 1 in HAT 7 density dependently . ^^^ At lower cell density , Notch 1 or Jagged 1 expressing cells were not seen . ^^^ However , when they were fully confluent , cells began to express Notch 1 or Jagged 1 strongly . ^^^ Some ALP positive cells were almost consistent with Notch 1 expressing cells but not Jagged 1 expressing cells . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Here we report that the suppression of Notch signaling in NIH 3T3 cells by the expression of either the extracellular domain of the Notch ligand Jagged 1 or dominant negative forms of Notch 1 and Notch 2 results in the appearance of an exaggerated fibroblast growth factor ( FGF ) dependent transformed phenotype characterized by anchorage independent growth in soft agar . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| We also investigated the gene expressions of Notch receptor 1 ( Notch 1 ) and its ligand Jagged 1 in BM cell differentiation . ^^^ Gene expressions of Notch 1 and Jagged 1 were detected in cultured BM cells on day 3 . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Expression is first detected in the circumvallate papilla at embryonic day E14 . 5 , when Notch 1 , Jagged 1 , and Jagged 2 are expressed broadly in the papilla and general lingual epithelium . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| The FGF 10 positive pancreatic cells expressed Notch 1 and Notch 2 , the Notch ligand genes Jagged 1 and Jagged 2 , as well as the Notch target gene Hes 1 . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Jagged 1 stimulation of endothelial cells induces a similar mesenchymal transformation , and Jagged 1 , Notch 1 , and Notch 4 are expressed in the ventricular outflow tract during stages of endocardial cushion formation . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Expression of Notch 1 , Jagged 1 , and Jagged 2 frequently overlapped , whereas Notch 2 expression was restricted to specific crypt cells , the lamina propria of the large intestine , and Peyer ' s patch lymphocytes . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Based on the role of the Notch / Delta / Jagged system in cell fate specification and recent reports linking Notch signaling with normal bile duct formation in mouse and human liver , we examined the expression of Notch 1 , Notch 2 , Notch 3 , Delta 1 , Delta 3 , Jagged 1 , and Jagged 2 , and delta like protein / preadipocyte factor 1 / fetal antigen 1 ( dlk ) in four well defined experimental rat models of liver injury and regeneration . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Similar vascular defects are observed in Jagged 1 and Notch 1 knockout mice . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| We show here that 17 beta estradiol promoted a 6 fold increase in Jagged 1 expression and an 8 fold increase in Notch 1 expression by cDNA arrays in breast cancer MCF 7 cells . ^^^ A similar up regulation of both Notch 1 receptor and Jagged 1 ligand was found in endothelial cells . ^^^ Additionally , imperfect estrogen responsive elements were found in the 5 ' untranslated region of Notch 1 and Jagged 1 genes . ^^^ Treatment with 17 beta estradiol also led to an activation of Notch signaling in MCF 7 cells expressing Notch 1 reporter gene or by promoting Jagged 1 induced Notch signaling in coculture assays . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Expression of Manic Fringe by a recombinant adenovirus , dominant negative Jagged 1 , or small interfering RNA against Jagged 1 inhibits the tumorigenicity of CaSki , an ICC derived cell line that was previously shown to be susceptible to growth inhibition induced by antisense Notch 1 . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Notch 1 and Jagged 1 are expressed after CNS demyelination , but are not a major rate determining factor during remyelination . ^^^ In this study , we show that Notch 1 is expressed on adult OPCs and that there are multiple cellular sources of its ligand Jagged 1 in a rodent model of remyelination . ^^^ Thus , in contrast to developmental myelination , adult expression of Notch 1 and Jagged 1 neither prevents nor plays a major rate determining role in remyelination . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| In S shaped bodies , Hes 1 expression was detected in the middle part which gives rise to the proximal tubule , but also extended into the lower and upper parts which give rise to the glomerulus and distal tubule , respectively , and was similar to the proximal distal expression patterns for Notch 1 and Jagged 1 in these nephrogenic structures . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Here , we report on the expression pattern of Notch 1 4 , Jagged 1 ( Jag 1 ) , Jag 2 , Delta like 1 ( Dll 1 ) , Dll 3 , Dll 4 , Rbpsuh , Deltex 1 ( Dtx 1 ) and Dtx 2 genes during preimplantation development from unfertilized eggs until late blastocyst stage using a RT PCR strategy . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| RT PCR showed high level expression of both Notch 1 and its ligand , Jagged 1 , in the cultured Mks . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Mice with simultaneous inactivation of Jagged 1 and Notch 1 in the BM compartment survived normally following a 5FU based in vivo challenge . ^^^ In addition , Notch 1 deficient HSCs were able to reconstitute mice with inactivated Jagged 1 in the BM stroma even under competitive conditions . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Compared with other Notch ligands , Delta 4 was slightly weaker than Jagged 2 , but stronger than Delta 1 and Jagged 1 in terms of Notch 1 ligands . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Fringe glycosyltransferases differentially modulate Notch 1 proteolysis induced by Delta 1 and Jagged 1 . ^^^ Interestingly , suppression of Jagged 1 induced Notch 1 signaling did not correlate with changes in Jagged 1 binding as found for Delta 1 . ^^^ Our data support the idea that fringe glycosylation increases Delta 1 binding to potentiate signaling , but we propose that although fringe glycosylation does not reduce Jagged 1 binding to Notch 1 , the resultant ligand receptor interactions do not effectively promote Notch 1 proteolysis required for activation of downstream signaling events . . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Testosterone influenced the expression of Notch 1 , Notch 2 and Jagged 1 induced by lipopolysaccharide in macrophages . ^^^ Expression of Notch family members ( including Notch 1 , Notch 2 and Jagged 1 ) was investigated at transcription and post transcription levels through RT PCR and Western blotting assay followed by densitometric analyses . ^^^ Results showed that testosterone influenced the lipopolysaccharide induced expression of Notch 1 , Notch 2 and Jagged 1 in macrophages . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Activation of Notch receptors by Jagged 1 or forced expression of the constitutively active Notch 1 intracellular domain in C3H10T1 / 2 fibroblasts inhibited myocardin dependent transcription of SMC restricted genes and activity of multiple SMC restricted transcriptional regulatory elements . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| AML primary samples show high levels of JAGGED 1 expression despite the low NOTCH 1 pathway activation , consistent with an autonomous JAGGED 1 signaling in myeloid leukemogenesis . . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| We have shown that both Delta 1 and Jagged 1 were expressed concomitantly with Notch 1 in maturating osteoblastic cells during bone regeneration and that overexpressed and immobilized recombinant Delta 1 and Jagged 1 alone did not alter the differentiated state of MC3T3 E 1 and C2C12 cells . ^^^ These results indicate the functional redundancy between Delta 1 and Jagged 1 in osteoblastic differentiation whereby Delta1 / Jagged1 activated Notch 1 enhances BMP 2 induced differentiation through the identical signaling pathway . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| The functional study of this signaling pathway has been difficult because mice with targeted mutations in Jagged 1 , Notch 1 , or Notch 2 have an embryonic lethal phenotype . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| METHODS : By performing comparative histology for adult and embryonic pancreatic markers in caerulein treated and control pancreas , we addressed cellular proliferation and differentiation ( amylase , DBA agglutinin , insulin , glucagon , beta catenin , E cadherin , Pdx 1 , Nkx6 . 1 , Notch 1 , Notch 2 , Jagged 1 , Jagged 2 , Hes 1 ) , hereby describing the kinetics of tissue restoration . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Expression of Notch 1 and its ligands , Delta like 1 and Jagged 1 , is critical for glioma cell survival and proliferation . ^^^ We show that Notch 1 and its ligands , Delta like 1 and Jagged 1 , are overexpressed in many glioma cell lines and primary human gliomas . ^^^ Down regulation of Notch 1 , Delta like 1 , or Jagged 1 by RNA interference induces apoptosis and inhibits proliferation in multiple glioma cell lines . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| In situ histochemistry analysis revealed that Notch 1 , 2 , and 4 and Notch ligand ( Delta 1 4 , and Jagged 1 ) proteins were not expressed in the yolk sac blood islands , the para aortic splanchnopleure , the hematopoietic aortic clusters , and at the early stages of embryonic liver hematopoiesis . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| The bile duct like differentiation of hepatocytes was associated with increased expression of Jagged 1 , Jagged 2 , Notch 1 , and several Notch target genes . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Unique patterns of Notch 1 , Notch 4 and Jagged 1 expression in ovarian vessels during folliculogenesis and corpus luteum formation . ^^^ Here , we characterize the expression patterns of Notch 1 , Notch 4 , and Jagged 1 proteins during the process of folliculogenesis and corpus luteum formation in the mouse ovary , an organ with dynamic physiological angiogenic growth . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| We have shown that the transcript and protein levels of HES 1 , the Notch 2 and Notch 1 receptors and the Jagged 1 ligand are induced in meningiomas of all grades , whereas induction of TLE 2 and TLE 3 occurs specifically in higher grade meningiomas . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| To investigate which O fucose sites on Notch 1 are important for ligand mediated signaling , we mutated the three invariant O fucose sites in mouse Notch 1 , along with several less highly conserved sites , and evaluated their ability to transduce Jagged 1 and Delta 1 mediated signaling in a cell based assay . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Knock out mice for Notch 1 , Notch 2 , Delta 1 and Jagged 1 are embryonic lethal . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Jagged 1 expressing cells line the adult SVZ and are juxtaposed to Notch 1 expressing cells , some of which are putative NSCs . ^^^ In vitro , endogenous Jagged 1 acts through Notch 1 to promote NSC maintenance and multipotency . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| In contrast , when medium Ca2+ is raised to > 400 micromol / L , Notch 1 conformationally is no longer constitutively active but requires cell cell contact for reciprocal binding of Jagged 1 ligands and Notch 1 receptors between adjacent transit amplifying cells to activate their survival signaling . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| METHODS : In this study , we analyzed the immunohistochemical staining pattern of four Notch receptors ( Notch 1 4 ) and their ligands ( Delta 1 and Jagged 1 ) in 14 synovial tissues obtained from 14 RA patients . ^^^ Notch 1 , Notch 3 , Delta 1 , and Jagged 1 were overexpressed in the synovial lining and sublining cells on synovial hyperplastic lesions in all samples . ^^^ Notch 1 and Notch 3 expression overlapped with that of Jagged 1 , as determined by confocal microscopy . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| The Notch pathway ( Notch 1 / 4 , Jagged 1 / 2 , Delta 1 ) appears crucial in this process . ^^^ Activation of this signaling pathway by constitutive Notch 1 mutants and by Jagged 1 causes an angiogenic and invasive tumor phenotype . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Here , we have investigated , for the first time , the expression of Notch 1 , Notch 2 , Jagged 1 , Jagged 2 and Delta like 1 proteins , by immunohistochemistry , in a series of benign and malignant human melanocytic lesions : five common melanocytic nevi , five ' dysplastic nevi ' and 20 melanomas ( five in situ , five T 1 T2 , five T 3 T4 and five metastatic melanomas ) . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical and in situ hybridization studies showed that the stratum intermedium cells express the Notch 1 protein and Hes 1 mRNAs , while the IEE and ameloblasts express the Jagged 1 . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| We show that two of the naturally occurring Notch 1 activators , Jagged 1 and Delta 1 , are also expressed in the SVZ and within the RMS in the adult mouse brain . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Resting macrophages express Notch 1 , 2 , and 4 , as well as the Notch ligands Jagged 1 and 2 . ^^^ After treatment with LPS and / or IFN gamma , we observed a p 38 MAPK dependent increase in Notch 1 and Jagged 1 mRNA and protein levels . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| In this study , we detected the expression patterns of the activated form of Notch 1 ( actN 1 ) as well as those of endogenous Notch 1 , Jagged 1 ( Jag 1 ) , and Math 1 . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| ECFCs express Notch receptors , Notch 1 and Notch 2 , and Notch ligands Delta 1 , Delta 4 , and Jagged 1 . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Finally , in Alagille syndrome , mutations in the JAG 1 gene cause deficiency Jagged 1 , a ligand for Notch 1 , a receptor determining cell fate during early embryogenesis . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| In the developing heart , both Notch 1 and Notch 2 are expressed in the outflow tracts and the epicardium , in specific cell populations previously shown to express JAG 1 . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Importantly , sustained Notch 1 signaling was required for the maintenance of Notch ligand Jag 1 expression . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| In situ staining showed that rarely cycling HSCs sporadically attach to endosteal osteoblasts , while in vitro assays indicated that ligation of Jag 1 on osteoblasts by Notch 1 on HSCs promotes HSC proliferation . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| High level coexpression of JAG 1 and NOTCH 1 is observed in human breast cancer and is associated with poor overall survival . ^^^ High levels of JAG 1 and NOTCH 1 were noted in a subset of tumors with poor prognosis pathologic features ( P < 0 . 05 ) . ^^^ Patients with tumors expressing high levels of JAG 1 or NOTCH 1 had a significantly poorer overall survival compared with patients expressing low levels of these genes [ 5 year survival rate of 42 % versus 65 % and median survival of 50 versus 83 months , respectively , for JAG 1 ( Hi vs . ^^^ Moreover , a synergistic effect of high level JAG 1 and high level NOTCH 1 coexpression on overall survival was observed ( 5 year survival rate of 32 % and median survival of 40 months ; P = 0 . 003 ) . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| Bmp 7 , Fgfr2b , Jag 1 and Notch 1 transcripts were co expressed with DeltaNp 63 in wild type embryos , but were not detectable in the ectoderm of p 63 mutants . ^^^ |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78504 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|