| Interacting proteins: P46531 and P49841 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46531 and P49841 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46531 and P49841 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46531 and P49841 |
Pubmed |
SVM Score :0.0 |
| A contrasting pattern of expression was found in abnormal large neurons , which demonstrated elevated levels of Notch 1 , and glycogen synthase kinase 3beta ( GSK 3beta ) , and normal levels of APC . ^^^ |
|
| Interacting proteins: P46531 and P49841 |
Pubmed |
SVM Score :0.0 |
| Functionally , ligand activated signaling through the endogenous Notch 1 receptor was reduced in GSK3beta null fibroblasts , implying a positive role for GSK3beta in mammalian Notch signaling . ^^^ These studies reveal that GSK3beta modulates Notch 1 signaling , possibly through direct phosphorylation of the intracellular domain of Notch , and that the activity of GSK3beta protects the intracellular domain from proteasome degradation . . ^^^ |
|
| Interacting proteins: P46531 and P49841 |
Pubmed |
SVM Score :0.0 |
| Biochemical analysis demonstrated an inhibition of AKT and GSK3beta phosphorylation following Notch 1 engagement while other biochemical signals such as TCR and ERK phosphorylation remained intact . ^^^ |
|