| Interacting proteins: P49810 and P46531 |
Pubmed |
SVM Score :0.0 |
| PSEN 1 and PSEN 2 encode polytopic membrane proteins , termed presenilin 1 ( PS 1 ) and presenilin 2 ( PS 2 ) that play an essential role in intramembranous ( `` gamma secretase ' ' ) proteolysis of selected type 1 membrane proteins , that include Notch 1 and beta amyloid precursor protein ( APP ) . ^^^ |
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| Interacting proteins: P49810 and P46531 |
Pubmed |
SVM Score :0.0 |
| Presenilin 1 ( PS 1 ) and presenilin 2 play a critical role in the gamma secretase processing of amyloid precursor protein ( APP ) and Notch 1 . ^^^ |
|
| Interacting proteins: P49810 and P46531 |
Pubmed |
SVM Score :0.0 |
| Using highly sensitive in vivo assays , we demonstrate that the PS 2 D366A mutation not only blocks gamma secretase activity but also inactivates PS 2 activity in Notch signaling by inhibiting the proteolytic release of the cytoplasmic Notch 1 domain . ^^^ |
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| Interacting proteins: P49810 and P46531 |
Pubmed |
SVM Score :0.0 |
| Although PS 1 ( + / ) PS 2 ( / ) mice survive in relatively good health , complete deletion of both PS 2 and PS 1 genes causes a phenotype closely resembling full Notch 1 deficiency . ^^^ |
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| Interacting proteins: P49810 and P46531 |
Pubmed |
SVM Score :0.0 |
| Expressing PS 1 or PS 2 but not the intracellular form of Notch 1 in PS1 / 2 null cells restored normal caveolin 1 localization , demonstrating that presenilins are required for the subcellular trafficking of caveolin 1 independently from Notch activity . ^^^ |
|
| Interacting proteins: P49810 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49810 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|