| Interacting proteins: P49757 and P46531 |
Pubmed |
SVM Score :0.0 |
| Furthermore , m Numb can physically interact with mouse Notch 1 . ^^^ |
|
| Interacting proteins: P49757 and P46531 |
Pubmed |
SVM Score :0.0 |
| Differential expression of mammalian Numb , Numblike and Notch 1 suggests distinct roles during mouse cortical neurogenesis . ^^^ In the developing neocortex , Numblike is expressed in postmitotic neurons in the cortical plate , but not in progenitors within the ventricular zone where m Numb and Notch 1 are expressed . ^^^ We have also found that , in dividing cortical progenitors , Notch 1 is distributed around the entire membrane , unlike m Numb which is asymmetrically localized to the apical membrane . ^^^ We propose that an interplay between cell intrinsic mechanisms ( executed by m numb and numblike ) and cell extrinsic mechanisms ( mediated by Notch 1 ) may be involved in both progenitor cell proliferation and neuronal differentiation during mammalian cortical neurogenesis . . ^^^ |
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| Interacting proteins: P49757 and P46531 |
Pubmed |
SVM Score :0.0 |
| NUMB localizes in the basal cortex of mitotic avian neuroepithelial cells and modulates neuronal differentiation by binding to NOTCH 1 . ^^^ Consistent with this suggestion , we show ( 1 ) that c NUMB interferes with the nuclear translocation of activated c NOTCH 1 through direct binding to the PEST sequence in the cytoplasmic domain of c NOTCH 1 and ( 2 ) that c NUMB interferes with c NOTCH 1 mediated inhibition of neuronal differentiation . . ^^^ |
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| Interacting proteins: P49757 and P46531 |
Pubmed |
SVM Score :0.0 |
| Developmental changes in Notch 1 and numb expression mediated by local cell cell interactions underlie progressively increasing delta sensitivity in neural crest stem cells . ^^^ |
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| Interacting proteins: P49757 and P46531 |
Pubmed |
SVM Score :0.0 |
| We have studied the role of Notch 1 and its antagonist Numb in the activation of satellite cells during postnatal myogenesis . ^^^ The results indicate that satellite cell activation results in a heterogeneous population of precursor cells with respect to Notch 1 activity and that the balance between Notch 1 and Numb controls cellular homeostasis and cell fate determination . . ^^^ |
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| Interacting proteins: P49757 and P46531 |
Pubmed |
SVM Score :0.0 |
| Mammalian numb proteins promote Notch 1 receptor ubiquitination and degradation of the Notch 1 intracellular domain . ^^^ Here we report that the mammalian Numb protein promotes the ubiquitination of membrane bound Notch 1 receptor . ^^^ The phosphotyrosine binding ( PTB ) domain of Numb was required for both Notch 1 ubiquitination and down regulation of Notch 1 nuclear activity . ^^^ Numb mediated ubiquitination of Notch 1 was not dependent on the PEST region , which was previously shown to mediate Sel 10 dependent ubiquitination of Notch in the nucleus , suggesting a distinct E 3 ubiquitin ligase is involved . ^^^ In agreement we demonstrate that Numb interacts with the cytosolic HECT domain containing E 3 ligase Itch and that Numb and Itch act cooperatively to promote ubiquitination of membrane tethered Notch 1 . ^^^ |
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| Interacting proteins: P49757 and P46531 |
Pubmed |
SVM Score :0.0 |
| Also enriched were genes in semaphorin / neuropilin ( Sema3c and Nrp 1 ) , ephrin / Eph ( ephrin A 1 , B 1 , B 2 , and EphB 4 ) , delta / notch ( Hey 1 , Jagged 2 , Notch 1 , Notch 4 , Numb , and Siah1b ) , and Wingless ( Frizzled 4 and Tle 1 ) signaling pathways involved in vascular development and angiogenesis . ^^^ |
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| Interacting proteins: P49757 and P46531 |
Pubmed |
SVM Score :0.0 |
| Notch 1 and Numb genes are inversely expressed as oligodendrocytes differentiate . ^^^ We also provide evidence that OPCs and OLs express the Numb gene , a known negative regulator of Notch 1 activity . ^^^ In vitro , Numb expression showed to be inversely correlated to that of Notch 1 , with higher levels of Numb proteins in mature OLs , in association with myelin like membranes . . ^^^ |
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| Interacting proteins: P49757 and P46531 |
Pubmed |
SVM Score :0.0 |
| Mouse Numb homologs antagonize Notch 1 signaling pathways through largely unknown mechanisms . ^^^ Consistent with these results , expression of Cre recombinase in sensory neurons from numb conditional mutants results in reduced endocytosis , a significant increase in nuclear Notch 1 , and severe reductions in axon branch points and total axon length . ^^^ Conversely , overexpression of Numb , but not mutant Numb lacking alpha adaptin interacting domain , leads to accumulation of Notch 1 in markedly enlarged endocytic lysosomal vesicles , reduced nuclear Notch 1 , and dramatic increases in axonal length and branch points . ^^^ Taken together , our data provide evidence for previously unidentified functions of Numb and Numblike in sensory axon arborization by regulating Notch 1 via the endocytic lysosomal pathways . . ^^^ |
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| Interacting proteins: P49757 and P46531 |
Pubmed |
SVM Score :0.0 |
| Notch 1 interacts with the amyloid precursor protein in a Numb independent manner . ^^^ |
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| Interacting proteins: P49757 and P46531 |
Pubmed |
SVM Score :0.0 |
| Cell fate determinants Numb , Notch 1 , Shh and BMPs are abundantly expressed during development but mostly decline in the adult . ^^^ The mRNA expression levels of Notch 1 , Numb , Shh , BMP 4 and Msx 2 increased in the grey matter and / or white matter and in the ependyma rostral and caudal to the lesion site after injury . ^^^ In conclusion , the cell fate determinants Notch 1 , Numb , Shh , BMP 4 and Msx 2 are expressed in neurons and / or glial cells after injury in a time dependent manner , suggesting that these genes reflect to some extent an endogenous self repair potential by recapitulating some features of development . . ^^^ |
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| Interacting proteins: P49757 and P46531 |
Pubmed |
SVM Score :0.0 |
| While transcript levels of Hoxa 10 , Hoxa 11 , Desrt and Dll 1 were indistinguishable , the levels of Notch 1 , Numb and Lgr 8 in the gubernaculum and Insl 3 in the testes were lower in Lhr null than in wild type siblings . ^^^ |
|
| Interacting proteins: P49757 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49757 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49757 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49757 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49757 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49757 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49757 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49757 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49757 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49757 and P46531 |
Pubmed |
SVM Score :0.0 |
| NA |
|