| Interacting proteins: Q9Y4K4 and P46109 |
Pubmed |
SVM Score :0.0 |
| Two novel candidates for signalling partners of Crk family adapter proteins , the hematopoietic progenitor kinase 1 ( HPK 1 ) and the kinase homologous to SPS1 / STE20 ( KHS ) , were found to bind with great selectivity to the first SH 3 domains of c Crk and CRKL . ^^^ |
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| Interacting proteins: Q9Y4K4 and P46109 |
Pubmed |
SVM Score :0.0 |
| Adaptor proteins CRK and CRKL associate with the serine / threonine protein kinase GCKR promoting GCKR and SAPK activation . ^^^ In this study we showed that the adaptor proteins Crk and CrkL associated with GCKR . ^^^ When Crk 1 , Crk 2 , or CrkL was transiently expressed in HEK 293T cells along with GCKR , each coimmunoprecipitated with GCKR . ^^^ Furthermore , in the Bcr Abl transformed cell line , K 562 endogenous GCKR and CrkL coimmunoprecipitated , indicating a constitutive association . ^^^ Detection of the CrkL GCKR interaction required the SH 3 domains of CrkL and 2 regions in GCKR 1 between amino acids 387 and 395 that contains a consensus SH 3 binding motif and the other between amino acids 599 and 696 . ^^^ |
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