| Interacting proteins: Q9UQC2 and P46109 |
Pubmed |
SVM Score :0.0 |
| We found that PD 180970 inhibited in vivo tyrosine phosphorylation of p210Bcr Abl ( IC 50 = 170 nM ) and the p210BcrAbl substrates Gab 2 and CrkL ( IC 50 = 80 nM ) in human K 562 chronic myelogenous leukemic cells . ^^^ |
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| Interacting proteins: Q9UQC2 and P46109 |
Pubmed |
SVM Score :0.0 |
| Gab 2 becomes tyrosine phosphorylated in response to a variety of growth factors and forms multimolecular complexes with SH 2 domain containing signaling molecules such as the p 85 regulatory subunit of the phosphoinositide 3 kinase ( p 85 PI3K ) , the tyrosine phosphatase SHP 2 and the adapter protein CrkL . ^^^ |
|
| Interacting proteins: Q9UQC2 and P46109 |
Pubmed |
SVM Score :0.0 |
| Overexpression of Gab 2 in K 562 cells resulted in transcriptional activation of the c fos serum response element ( SRE ) promoter , whereas overexpression of SHP 2 , Grb 2 , and CrkL had no effect . ^^^ |
|
| Interacting proteins: Q9UQC2 and P46109 |
Pubmed |
SVM Score :0.0 |
| NA |
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