| Interacting proteins: Q92918 and P46109 |
Pubmed |
SVM Score :0.0 |
| Two novel candidates for signalling partners of Crk family adapter proteins , the hematopoietic progenitor kinase 1 ( HPK 1 ) and the kinase homologous to SPS1 / STE20 ( KHS ) , were found to bind with great selectivity to the first SH 3 domains of c Crk and CRKL . ^^^ |
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| Interacting proteins: Q92918 and P46109 |
Pubmed |
SVM Score :0.0 |
| Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c Jun N terminal kinase . ^^^ We found that HPK 1 interacted with Crk and CrkL adaptor proteins in vitro and in vivo and that the proline rich motifs within HPK 1 were involved in the differential interaction of HPK 1 with the Crk proteins and Grb 2 . ^^^ Crk and CrkL not only activated HPK 1 but also synergized with HPK 1 in the activation of JNK . ^^^ The HPK 1 mutant ( HPK 1 PR ) , which encodes the proline rich region alone , blocked JNK activation by Crk and CrkL . ^^^ Interestingly , HPK 1 phosphorylated Crk and CrkL , mainly on serine and threonine residues in vitro . ^^^ |
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| Interacting proteins: Q92918 and P46109 |
Pubmed |
SVM Score :0.0 |
| HPK 1 interacts , through its proline rich domains , with growth factor receptor bound 2 ( Grb 2 ) , CT 10 regulated kinase ( Crk ) , and Crk like ( CrkL ) adaptor proteins . ^^^ |
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| Interacting proteins: Q92918 and P46109 |
Pubmed |
SVM Score :0.0 |
| Upon TCR / CD3 stimulation , HPK 1 formed inducible complexes with the adapters Nck and Crk with different kinetics , whereas it constitutively interacted with the adapters Grb 2 and CrkL in Jurkat T cells . ^^^ |
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| Interacting proteins: Q92918 and P46109 |
Pubmed |
SVM Score :0.0 |
| The HPK 1 association with Crk , CrkL , and HIP 55 mediate HPK 1 dependent c Jun N terminal kinase ( JNK ) activation , while the association of HPK 1 with SLP 76 , Gads , CrkL , Grb 2 , and Grap affect T and B cell dependent gene transcription . ^^^ Lastly , HPK 1 will phosphorylate Crk and CrkL , in vitro , which presents a novel possibility for the regulation of adaptor proteins and downstream signaling events . . ^^^ |
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