| Interacting proteins: Q14511 and P46109 |
Pubmed |
SVM Score :0.0 |
| Both HEF 1 and Cas were found to complex with the related adhesion focal tyrosine kinase ( RAFTK ) , and when tyrosine phosphorylated , with the adapter molecule CrkL . ^^^ |
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| Interacting proteins: Q14511 and P46109 |
Pubmed |
SVM Score :0.0 |
| Differential signaling after beta 1 integrin ligation is mediated through binding of CRKL to p 120 ( CBL ) and p 110 ( HEF 1 ) . ^^^ However , in the lymphoid H 9 cell line , the major tyrosine phosphorylated CRKL binding protein was p 110 ( HEF 1 ) . ^^^ Thus , in different cell types CRKL and its SH 3 associated proteins may form different multimeric complexes depending on whether p 120 ( CBL ) or p 110 ( HEF 1 ) is tyrosine phosphorylated after integrin ligation . ^^^ The shift in association of CRKL and its SH 3 associated proteins from p 120 ( CBL ) to p 110 ( HEF 1 ) could contribute to different functional outcomes of `` outside in ' ' integrin signaling in different cells . . ^^^ |
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| Interacting proteins: Q14511 and P46109 |
Pubmed |
SVM Score :0.0 |
| BCR / ABL induced leukemogenesis causes phosphorylation of Hef 1 and its association with Crkl . ^^^ The proto oncoprotein p 120 ( Cbl ) and Hef 1 , but not p 130 ( Cas ) , were detectably phosphorylated on tyrosine in P190Bcr / Abl expressing leukemic cells and were found in complex with Crkl , showing the existence of protein complexes in P190Bcr / Abl leukemic cells , consisting of P190Bcr / Abl , Crkl , and Hef 1 or p 120 ( Cbl ) . ^^^ |
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| Interacting proteins: Q14511 and P46109 |
Pubmed |
SVM Score :0.0 |
| Association of the Cas like molecule HEF 1 with CrkL following integrin and antigen receptor signaling in human B cells : potential relevance to neoplastic lymphohematopoietic cells . ^^^ Immunodepletion studies indicated that all the tyrosine phosphorylated HEF 1 or Cas was complexed with CrkL . ^^^ Furthermore , the guanine nucleotide exchange factor C3G , which is thought to be involved in the regulation of the ras pathway and constitutively binds to the C terminal SH 3 domain of CrkL , could be detected in HEF 1 immunoprecipitates . ^^^ Therefore , CrkL is involved in the formation of a HEF 1 CrkL C3G ternary complex in B cells , suggesting that it is likely to play an important role , allowing the propagation of the stimulation initiated by both BCR and beta 1 integrin ligation . . ^^^ |
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| Interacting proteins: Q14511 and P46109 |
Pubmed |
SVM Score :0.0 |
| The SH 2 domain of CRKL can bind to tyrosine phosphorylated proteins such as CBL , HEF 1 , CAS or paxillin . ^^^ |
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| Interacting proteins: Q14511 and P46109 |
Pubmed |
SVM Score :0.0 |
| Differential interaction of Crkl with Cbl or C3G , Hef 1 , and gamma subunit immunoreceptor tyrosine based activation motif in signaling of myeloid high affinity Fc receptor for IgG ( Fc gamma RI ) . ^^^ Fc gamma RI cross linking of U937IF cells results in the tyrosine phosphorylation of Cbl , Crkl , and Hef 1 , an increase in the association of Crkl with Cbl via direct SH 2 domain interaction and increased Crkl Hef 1 binding . ^^^ Anti Crkl immunoprecipitations demonstrate that the ITAM containing gamma subunit of Fc gamma RI is induced to form a complex with the Crkl protein , and Crkl binds to the cytoskeletal protein , Hef 1 . ^^^ The induced association of Crkl with Cbl , Hef 1 , and Fc gamma RI gamma after Fc gamma RI activation and the constitutive association between C3G and Crkl provide the first evidence that a Fc gamma RI gamma Crkl C3G complex may link ITAM receptors to the activation of Rap 1 in myeloid cells . . ^^^ |
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| Interacting proteins: Q14511 and P46109 |
Pubmed |
SVM Score :0.0 |
| Crkl binds to BCR / ABL through its N terminal SH 3 domain and is known to interact with several signaling proteins that have been implicated in integrin signaling , including Cbl , Cas , Hef 1 , and paxillin . ^^^ |
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