| Interacting proteins: Q07889 and P46109 |
Pubmed |
SVM Score :0.0 |
| HGF stimulated Gab 1 association with c Met , Grb 2 , SHP 2 , PI3K , Shc , Crk isoforms and CrkL , but not with PLCgamma 1 . ^^^ |
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| Interacting proteins: Q07889 and P46109 |
Pubmed |
SVM Score :0.0 |
| Signaling of hepatocyte growth factor / scatter factor ( HGF ) to the small GTPase Rap 1 via the large docking protein Gab 1 and the adapter protein CRKL . ^^^ Stimulation of human embryonic kidney cells ( HEK 293 ) with HGF leads to Gab 1 association with CRKL . ^^^ The results presented here delineate a novel signaling pathway from HGF to the GTPase Rap 1 which depends on the interaction of the adapter protein CRKL with the exchange factor C3G and could be linked to cell migration . . ^^^ |
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| Interacting proteins: Q07889 and P46109 |
Pubmed |
SVM Score :0.0 |
| In this study , we demonstrate that HGF induces strong tyrosine phosphorylation of the proto oncogene product c Cbl in B cells and increases Cbl association with the Src family tyrosine kinases Fyn and Lyn , as well as with phosphatidylinositol 3 kinase and CrkL . ^^^ |
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| Interacting proteins: Q07889 and P46109 |
Pubmed |
SVM Score :0.0 |
| HGF stimulation of epithelial cell colonies leads to the enhanced recruitment of the CrkII and CrkL adapter proteins to Met dependent signaling complexes . ^^^ |
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