| Interacting proteins: P56945 and P46109 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P46109 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P46109 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P46109 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P46109 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P46109 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P46109 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56945 and P46109 |
Pubmed |
SVM Score :0.6212006 |
| Here we demonstrate that another cellular protein linked to BCR / ABL through the CRKL SH 2 domain is p 130 ( CAS ) . p 130 ( CAS ) was found to be tyrosine phosphorylated and associated with CRKL in BCR / ABL expressing cell lines and in samples obtained from CML and ALL patients , but not in samples from controls . 0.6212006^^^ |
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| Interacting proteins: P56945 and P46109 |
Pubmed |
SVM Score :0.0 |
| The SH 2 domain of CRKL can bind to tyrosine phosphorylated proteins such as CBL , HEF 1 , CAS or paxillin . ^^^ |
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| Interacting proteins: P56945 and P46109 |
Pubmed |
SVM Score :0.0 |
| Furthermore , pretreatment of CTS cells with AG 490 significantly inhibited SDF 1alpha induced PI 3 kinase activity , and inhibition of JAK 2 with AG 490 ablated the SDF 1alpha induced tyrosine phosphorylation of multiple focal adhesion proteins ( including focal adhesion kinase , related adhesion focal tyrosine kinase , paxillin , CrkII , CrkL , and p130Cas ) . ^^^ |
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| Interacting proteins: P56945 and P46109 |
Pubmed |
SVM Score :0.0 |
| Combined treatment with siRNAs to Crk and CrkL , which bind to the p130cas substrate domain , inhibited cell spreading by 54 % . ^^^ Both p130cas siRNA and the combined Crk / CrkL siRNAs strongly inhibited ( 52 and 46 % inhibition , respectively ) Caco 2 sheet migration on collagen 4 and noticeably inhibited lamellipodial extension , whereas paxillin siRNA only inhibited migration by 18 % and did not noticeably affect lamellipodial extension . ^^^ |
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| Interacting proteins: P56945 and P46109 |
Pubmed |
SVM Score :0.0 |
| Both HEF 1 and Cas were found to complex with the related adhesion focal tyrosine kinase ( RAFTK ) , and when tyrosine phosphorylated , with the adapter molecule CrkL . ^^^ |
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| Interacting proteins: P56945 and P46109 |
Pubmed |
SVM Score :0.0 |
| The proto oncoprotein p 120 ( Cbl ) and Hef 1 , but not p 130 ( Cas ) , were detectably phosphorylated on tyrosine in P190Bcr / Abl expressing leukemic cells and were found in complex with Crkl , showing the existence of protein complexes in P190Bcr / Abl leukemic cells , consisting of P190Bcr / Abl , Crkl , and Hef 1 or p 120 ( Cbl ) . ^^^ |
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| Interacting proteins: P56945 and P46109 |
Pubmed |
SVM Score :0.0 |
| Association of the Cas like molecule HEF 1 with CrkL following integrin and antigen receptor signaling in human B cells : potential relevance to neoplastic lymphohematopoietic cells . ^^^ Immunodepletion studies indicated that all the tyrosine phosphorylated HEF 1 or Cas was complexed with CrkL . ^^^ |
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| Interacting proteins: P56945 and P46109 |
Pubmed |
SVM Score :0.0 |
| Crkl binds to BCR / ABL through its N terminal SH 3 domain and is known to interact with several signaling proteins that have been implicated in integrin signaling , including Cbl , Cas , Hef 1 , and paxillin . ^^^ |
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| Interacting proteins: P56945 and P46109 |
Pubmed |
SVM Score :0.0 |
| Moreover , FcepsilonRI clustering causes both Dok 1 and Dok 2 to become docking sites for other signaling molecules including Nck , CrkL and Cas . ^^^ |
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| Interacting proteins: P56945 and P46109 |
Pubmed |
SVM Score :0.0 |
| The adapter protein Crk Like ( CrkL ) can associate with the Src substrate p 130 ( Cas ) ( Cas ) . ^^^ The biological role of CrkL downstream of Cas , however , has been largely obscure . ^^^ Consistent with the ability of CrkL to biochemically associate with Cas , we found that Src triggers translocation of CrkL to focal adhesions ( FAs ) in a manner dependent on Cas . ^^^ |
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