| Interacting proteins: P46109 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P49023 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P49023 |
Pubmed |
SVM Score :1.2469516 |
| Similar effects of insulin like growth factor 1 treatment on the association of CrkL with tyrosine phosphorylated paxillin were observed in fibroblasts overexpressing CrkL . 1.2469516^^^ |
|
| Interacting proteins: P46109 and P49023 |
Pubmed |
SVM Score :0.0 |
| The SH 2 domain of CRKL can bind to tyrosine phosphorylated proteins such as CBL , HEF 1 , CAS or paxillin . ^^^ |
|
| Interacting proteins: P46109 and P49023 |
Pubmed |
SVM Score :0.0 |
| CRKL links p210BCR / ABL with paxillin in chronic myelogenous leukemia cells . ^^^ Several other phosphoproteins were also detected in anti CRKL immunoprecipitates , one of which has been identified as paxillin , a 68 kDa focal adhesion protein which we have previously shown to be phosphorylated by p210BCR / ABL . ^^^ Using GST CRKL fusion proteins , the SH 3 domains of CRKL were found to bind c ABL and p210BCR / ABL , while the SH 2 domain of CRKL bound to paxillin , suggesting that CRKL could physically link p210BCR / ABL to paxillin . ^^^ Paxillin contains three tyrosines in Tyr 10 10 Pro ( Y 10 10 P ) motifs consistent with amino acid sequences predicted to be optimal for binding to the CRKL SH 2 domain ( at positions Tyr 31 , Tyr 118 , and Tyr 181 ) . ^^^ Each of these tyrosine residues was mutated to a phenylalanine residue , and in vitro binding assays indicated that paxillin tyrosines at positions 31 and 118 , but not 181 , are likely to be involved in CRKL SH 2 binding . ^^^ |
|
| Interacting proteins: P46109 and P49023 |
Pubmed |
SVM Score :0.0 |
| In cells transformed by BCR / ABL we have previously shown that CRKL is associated with two focal adhesion proteins , tensin and paxillin , suggesting that CRKL could be involved in integrin signaling . ^^^ |
|
| Interacting proteins: P46109 and P49023 |
Pubmed |
SVM Score :0.0 |
| When phosphorylated , Crkl binds through its Src homology 2 ( SH 2 ) domain to other tyrosine phosphoproteins such as paxillin and Cbl . ^^^ |
|
| Interacting proteins: P46109 and P49023 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of a number of substrates such as GAP , GRB 2 , SHC , FES , CRKL , and paxillin is considered a decisive step in transformation . ^^^ |
|
| Interacting proteins: P46109 and P49023 |
Pubmed |
SVM Score :0.0 |
| Crkl binds to BCR / ABL through its N terminal SH 3 domain and is known to interact with several signaling proteins that have been implicated in integrin signaling , including Cbl , Cas , Hef 1 , and paxillin . ^^^ |
|
| Interacting proteins: P46109 and P49023 |
Pubmed |
SVM Score :0.0 |
| Platelets express an SH 2 SH3 adapter molecule , CrkL , that can directly associate with paxillin , which is localized in podosomes . ^^^ WASP , CrkL , syk , and paxillin like Hic 5 incorporated to platelet cytoskeleton after platelet aggregation . ^^^ |
|
| Interacting proteins: P46109 and P49023 |
Pubmed |
SVM Score :0.0 |
| Furthermore , pretreatment of CTS cells with AG 490 significantly inhibited SDF 1alpha induced PI 3 kinase activity , and inhibition of JAK 2 with AG 490 ablated the SDF 1alpha induced tyrosine phosphorylation of multiple focal adhesion proteins ( including focal adhesion kinase , related adhesion focal tyrosine kinase , paxillin , CrkII , CrkL , and p130Cas ) . ^^^ |
|
| Interacting proteins: P46109 and P49023 |
Pubmed |
SVM Score :0.0 |
| Furthermore , GST CD34i ( full ) did not bind c Abl , c Cbl , C3G , or paxillin proteins that are known to associate with CrkL , suggesting that CD 34 directly interacts with the CrkL protein . ^^^ |
|
| Interacting proteins: P46109 and P49023 |
Pubmed |
SVM Score :0.0 |
| We show that the overexpression of CrkII or CrkL , but not Src homology 2 or amino terminal Src homology 3 domain mutant Crk proteins , promotes the relocalization of Paxillin to focal contacts throughout the cell and within lamellipodia in a Rac dependent manner . ^^^ |
|
| Interacting proteins: P46109 and P49023 |
Pubmed |
SVM Score :0.0 |
| Both p130cas siRNA and the combined Crk / CrkL siRNAs strongly inhibited ( 52 and 46 % inhibition , respectively ) Caco 2 sheet migration on collagen 4 and noticeably inhibited lamellipodial extension , whereas paxillin siRNA only inhibited migration by 18 % and did not noticeably affect lamellipodial extension . ^^^ |
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