| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| CRKL has one SH 2 and two SH 3 domains , with 60 % homology to CRK 2 . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| CrkL is a member of the Crk family of adapter proteins consisting mostly of SH 2 and SH 3 domains . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| It interacts with SH 2 containing proteins such as phosphatidylinositol 3 ' kinase ( PI3K ) , Grb 2 , Crk 2 , and CrkL . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| Overexpression of Crkii also augmented spontaneous migration but to a lesser degree than did Crkl . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| There is an activation induced association of tyrosine phosphorylated Cbl with Grb 2 and CrkL , respectively , but not CrkII . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| Here we identify CrkII , CrkL and Dock 1 in complexes bound to tyrosine phosphorylated Dab 1 , through mass spectrometry . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| HGF stimulated Gab 1 association with c Met , Grb 2 , SHP 2 , PI3K , Shc , Crk isoforms and CrkL , but not with PLCgamma 1 . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| Currently comprising four members , 5 Crk , CrkI , CrkII and Crk like protein , we have introduced a fifth member , CrkIII . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| In primary neutrophils from patients with CML , the major novel tyrosine phosphorylated protein is CRKL , an SH 2 SH3 SH 3 linker protein which has an overall homology of 60 % to CRK , the human homologue of the 5 crk oncogene product . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| CRK , CRKL , and other SH 2 ( SRC homology domain ) / SH3 containing proteins function as adaptor molecules in nonreceptor tyrosine kinase signalling pathways . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| The protein binding properties of Crk were subsequently compared to CRKL , the product of a homologous but distinct gene , and found to be very similar . ^^^ The binding of two guanine nucleotide exchange factors , Sos and C3G , to Crk and CRKL indicates that Ras or related proteins likely play a role in signaling through Crk family proteins . . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| Using K 562 cells as a source of protein , the 39 kDa protein was purified and identified by microsequencing as Crkl , an SH2 / SH3 adaptor protein related to the crk oncogene of the avian sarcoma virus , CT 10 . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| Here we show that Cbl associates with all three forms of the human Crk protein , predominantly CrkL , following T cell receptor activation of Jurkat T cells . ^^^ Anti Cbl antibody completely immunodepleted the CrkL associated 120kDa phosphotyrosyl polypeptide , suggesting that the recently described p130cas related Crk associated p 116 of T cells may be Cbl . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| EGF stimulation also induced the association of Cbl with Src homology and collagen ( Shc ) protein , p 85 subunit of the phosphatidylinositol 3 kinase and Crk proteins , in particular with the CrkL isoform . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| CRKL has one SH 2 domain and two SH 3 domains and is structurally related to c CRK 2 ( CRK ) and the 5 Crk oncoprotein . ^^^ We have previously shown that CRKL , but not the related adapter protein c CRK , is tyrosine phosphorylated in cell lines transformed by BCR / ABL , and that CRKL binds to BCR / ABL through the CRKL SH 3 domains . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| The BCR / ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins . ^^^ In primary leukemic neutrophils from patients with CML , the major tyrosine phosphorylated protein is CRKL , an SH 2 SH3 SH 3 adapter protein which has an overall homology of 60 % to CRK , the human homologue of the 5 crk oncogene . ^^^ In cell lines transformed by BCR / ABL , CRKL was tyrosine phosphorylated , while CRK was not . ^^^ We looked for changes in CRK and CRKL binding proteins in Ba / F3 hematopoietic cell lines which were transformed by BCR / ABL . ^^^ Anti CRK 2 or anti CRKL immunoprecipitates were probed by far Western blotting with CRK 2 or CRKL GST fusion proteins to display CRK and CRKL coprecipitating proteins . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| Of the three Crk isoforms expressed in hematopoietic cells ( CrkL , CrkII , and CrkI ) , tyrosine phosphorylated Cbl binds preferentially to CrkL and CrkII . ^^^ The amount of Cbl associated with CrkL and CrkII exceeded the fraction of Cbl associated with Grb 2 indicating that unlike other receptor systems , the Cbl Crk association represents the dominant complex of Cbl in growth factor stimulated hematopoietic cells . ^^^ In factor dependent hematopoietic cell lines , CrkL constitutively associated with the guanine nucleotide release factor , C3G , which is known to interact via Crk src homology 3 ( SH 3 ) domains . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| In vitro binding assays demonstrated that , among these Syk associated proteins , pp 40 , which differed from Erks , Crk , and Crkl , binds Syk through SH 2 domains of Syk and is a prominent tyrosine phosphorylated protein in integrin cross linked cells . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| Enhancement of guanine nucleotide exchange activity of C3G for Rap 1 by the expression of Crk , CrkL , and Grb 2 . ^^^ In the present study , we analyzed the effect of Crk , CrkL , and Grb 2 on the C3G Rap 1 pathway . ^^^ Expression of Crk , CrkL , and Grb 2 with C3G in Cos 1 cells significantly increased the ratio of GTP / GDP bound to Rap 1 . ^^^ These results demonstrate that Crk , CrkL , and Grb 2 positively modulate the C3G Rap 1 pathway primarily by recruiting C3G to the cell membrane . . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| In vivo regulation of CrkII and CrkL proto oncogenes in the uterus by insulin like growth factor 1 . ^^^ Changes in CrkII and CrkL phosphorylation are associated with insulin like growth factor receptor activation in cultured cells . ^^^ Paxillin , a 65 70 kDa phosphoprotein containing high affinity binding sites common for the Src homology 2 ( SH 2 ) domains of CrkII and CrkL , was observed in both CrkII and CrkL immunoprecipitates . ^^^ The different responses of CrkL and CrkII to insulin like growth factor 1 receptor activation suggest distinct roles for these two adapter proteins in signal transduction . . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| Analyses of partial amino acid sequences of the purified proteins indicated that they were identical to CrkI , CrkII and CrkL respectively . ^^^ The wild type PDGF alpha receptor , when expressed in porcine aortic endothelial cells , formed complexes with CrkII and CrkL upon ligand stimulation , which was specifically inhibited by a synthetic peptide containing phosphorylated Tyr 762 . ^^^ Tyrosine phosphorylation of CrkII and CrkL increased by 1 . 8 and 1 . 3 fold , respectively , upon ligand stimulation of the wild type alpha receptor . ^^^ CrkII and CrkL constitutively formed complex with the guanine nucleotide exchange factor C3G , in unstimulated as well as PDGF stimulated cells . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| Development of highly selective SH 3 binding peptides for Crk and CRKL which disrupt Crk complexes with DOCK 180 , SoS and C3G . ^^^ Based on previous ultrastructural studies , short motifs which bind to the first SH 3 domains of the adapters Crk and CRKL were selectively mutagenised to generate Crk / CRKL SH 3 binding peptides of very high affinity and selectivity . ^^^ A GST HACBP fusion protein precipitated Crk and CRKL proteins out of 35S labelled and unlabelled cell lysates . ^^^ Very little binding of other cellular proteins to HACBP was detectable , indicative of a great preference for Crk and CRKL when compared to the wide variety of other endogenous cellular proteins . ^^^ HACBP based molecules should therefore be useful as highly selective inhibitors of intracellular signalling processes involving Crk and CRKL . . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| Interplay of the proto oncogene proteins CrkL and CrkII in insulin like growth factor 1 receptor mediated signal transduction . ^^^ The closely related proto oncogene proteins CrkII and CrkL consist of one SH 2 and two SH 3 domains and share 60 % overall homology with the highest identity within their functional domains . ^^^ In this study we show that CrkL and CrkII may play overlapping but different roles in insulin like growth factor ( IGF ) 1 receptor mediated signal transduction . ^^^ Evidence supporting this hypothesis includes ( a ) the oncogenic potential of CrkL versus the absence of this potential in CrkII overexpressing cell lines , ( b ) the inhibition of IGF 1 dependent cell cycle progression by overexpression of CrkII , and ( c ) the differential regulation of the phosphorylation status of selective proteins in CrkII and CrkL overexpressing cell lines . ^^^ In addition we demonstrate the specific association of CrkL and CrkII with the newly characterized IRS 4 protein , again in a differential manner . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| The cellular homologs of 5 Crk includes CrkI , CrkII , and CrkL ; these have been isolated from species ranging from lower vertebrates to man . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| Two novel candidates for signalling partners of Crk family adapter proteins , the hematopoietic progenitor kinase 1 ( HPK 1 ) and the kinase homologous to SPS1 / STE20 ( KHS ) , were found to bind with great selectivity to the first SH 3 domains of c Crk and CRKL . ^^^ The interaction of HPK 1 with c Crk and CRKL was studied in more detail . ^^^ In vitro complexes were highly stable and in vivo complexes of c Crk and CRKL with HPK 1 were detectable by co immunoprecipitation with transiently transfected cells but also with endogenous proteins . ^^^ Furthermore , c Crk 2 and , to a lesser extent , CRKL were substrates for HPK 1 . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| In the current study we show that Crkl , but only a minor amount of the related Crk , form constitutive complexes in vivo with guanine nucleotide exchange factor C3G in 3T3 fibroblasts . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c Jun N terminal kinase . ^^^ We found that HPK 1 interacted with Crk and CrkL adaptor proteins in vitro and in vivo and that the proline rich motifs within HPK 1 were involved in the differential interaction of HPK 1 with the Crk proteins and Grb 2 . ^^^ Crk and CrkL not only activated HPK 1 but also synergized with HPK 1 in the activation of JNK . ^^^ The HPK 1 mutant ( HPK 1 PR ) , which encodes the proline rich region alone , blocked JNK activation by Crk and CrkL . ^^^ Interestingly , HPK 1 phosphorylated Crk and CrkL , mainly on serine and threonine residues in vitro . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor substrate ( IRS ) , SHC , GRB 2 , CRKII and CRKL adaptor proteins have all been implicated in transmitting signals to the nucleus of the cell . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| The dCRK protein has extensive homology to the both the Crk 2 form of vertebrate Crk and the Crk related protein CRKL , and includes one SH 2 domain followed by two SH 3 domains . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| The viral Crk oncogene ( 5 Crk ) is known to induce sarcomas in chicken and its cellular homologs c Crk 1 , c Crk 2 , and Crk like ( CRKL ) have been implicated in many signal transduction events . ^^^ Upstream proteins include various receptors and large multisite docking proteins , while several protein kinases and guanine nucleotide release proteins ( GNRPs ) have been suggested to function downstream of c Crk and CRKL . ^^^ Most Crk / CRKL SH 2 and SH 3 binding proteins contain several docking sites with considerable sequence similarity . ^^^ Thus the binding requirements of Crk / CRKL SH 2 and SH 3 domains are now well defined , providing a basis for the design of small inhibitory molecules to block the function of these adapter proteins . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| CrkL and CrkII participate in the generation of the growth inhibitory effects of interferons on primary hematopoietic progenitors . ^^^ We also show that both members of the Crk family , CrkL and CrkII , are phosphorylated in an interferon dependent manner in primary hematopoietic progenitors . ^^^ Furthermore , inhibition of CrkL or CrkII protein expression by antisense oligonucleotides , reverses the inhibitory effects of IFNalpha or IFNgamma on the proliferation of normal bone marrow progenitor cells ( colony forming units granulocytic / monocytic [ CFU GM ] and burst forming units erythroid [ BFU E ] ) . ^^^ Thus , both CrkL and CrkII are engaged in a signaling pathway ( s ) that mediates interferon regulated inhibition of hematopoietic cell proliferation . . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| In addition to the Jak Stat pathway , multiple other Jak kinase dependent signaling cascades are activated , including the IRS PI 3 ' kinase pathway , a pathway involving the vav proto oncogene product , and a pathway involving adaptor proteins of the Crk family ( CrkL and CrkII ) . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| HPK 1 interacts , through its proline rich domains , with growth factor receptor bound 2 ( Grb 2 ) , CT 10 regulated kinase ( Crk ) , and Crk like ( CrkL ) adaptor proteins . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| Adaptor proteins CRK and CRKL associate with the serine / threonine protein kinase GCKR promoting GCKR and SAPK activation . ^^^ In this study we showed that the adaptor proteins Crk and CrkL associated with GCKR . ^^^ When Crk 1 , Crk 2 , or CrkL was transiently expressed in HEK 293T cells along with GCKR , each coimmunoprecipitated with GCKR . ^^^ Crk or CrkL overexpression increased GCKR catalytic activity . ^^^ A dominant negative form of Ras abolished Crk or CrkL induced GCKR activation , suggesting a dependence on Ras activation for their activation of GCKR . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| Crk ( Crk 1 and 2 ) proteins and closely related CrkL are adapters which are commonly involved in various signaling processes in various cells , and these proteins share many ligands . ^^^ Using a beta casein promoter STAT 5 binding site as a probe , we have also demonstrated that CrkL ( a close relative of Crk ) antiserum , but not Crk antiserum , supershifted the STAT 5 DNA complex by an electrophoretic mobility shift assay , suggesting that CrkL , but not Crk , is the major component of the complex . ^^^ Thus , Crk and CrkL may have distinct roles in the regulation of STAT5 . . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| The Crk / CRKL binding region of the Rap 1 specific exchange factor C3G ( CBR ) inhibits the bombesin stimulated Rap 1 activity in transfected Swiss 3T3 cells . ^^^ The CBR is complexed with endogenous c Crk 2 and CRKL and blocks the protein association with catalytically active C3G . ^^^ We conclude that cellular Crk / CRKL complexes , recruited to upstream signaling components , contribute to basal and bombesin induced Rap 1 activity , which is independent from the Ras Raf Erk pathway under these circumstances . . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| CRKL maps within the common deletion region for DGS / VCFS ( ref . 2 ) and encodes an SH 2 SH3 SH 3 adapter protein closely related to the Crk gene products . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| Upon TCR / CD3 stimulation , HPK 1 formed inducible complexes with the adapters Nck and Crk with different kinetics , whereas it constitutively interacted with the adapters Grb 2 and CrkL in Jurkat T cells . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| Furthermore , pretreatment of CTS cells with AG 490 significantly inhibited SDF 1alpha induced PI 3 kinase activity , and inhibition of JAK 2 with AG 490 ablated the SDF 1alpha induced tyrosine phosphorylation of multiple focal adhesion proteins ( including focal adhesion kinase , related adhesion focal tyrosine kinase , paxillin , CrkII , CrkL , and p130Cas ) . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| Interestingly , there appears to be differential specificity between CrkL and CrkII for CD 34 , because GST CD34i ( full ) did not precipitate CrkII , a highly homologous Crk family member . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| Selective formation of multi protein complexes by the Crk and Crk like ( CRKL ) proteins depends on specific motifs recognized by their SH 2 and SH 3 domains . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| Colocalization of DOCK 2 with Crk like ( CrkL ) and F actin was shown by immunocytochemical analysis with the use of Jurkat cells . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND & OBJECTIVE : It was recently reported that the proteins coded by CRKL ( CT 10 regulator of kinase like , CRK like ) gene play an important role in the pathogenesis of chronic myeloid leukemia ( CML ) . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| Furthermore , MEFs lacking CrkL show impaired integrin induced migration despite expression of a closely related protein , Crk 2 , in these cells . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| We show that the overexpression of CrkII or CrkL , but not Src homology 2 or amino terminal Src homology 3 domain mutant Crk proteins , promotes the relocalization of Paxillin to focal contacts throughout the cell and within lamellipodia in a Rac dependent manner . ^^^ We have previously demonstrated that the CrkII and CrkL adapter proteins are required for the spreading of epithelial colonies and the breakdown of adherens junctions in response to hepatocyte growth factor . ^^^ When overexpressed , CrkII and CrkL promote lamellipodia formation , cell spreading , and the loss of epithelial adherens junctions in the absence of hepatocyte growth factor . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| HGF stimulation of epithelial cell colonies leads to the enhanced recruitment of the CrkII and CrkL adapter proteins to Met dependent signaling complexes . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| Of these , the Crk family proteins ( CrkL , CrkI , and CrkII ) , bind significant quantities of Dab 1 when embryonic cortical neurons are exposed to Reelin . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| We further show that Crk 1 and Crk 2 , but not CrkL , stimulate phosphorylation of Dab 1 on tyrosine 220 in a Src dependent manner . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| The HPK 1 association with Crk , CrkL , and HIP 55 mediate HPK 1 dependent c Jun N terminal kinase ( JNK ) activation , while the association of HPK 1 with SLP 76 , Gads , CrkL , Grb 2 , and Grap affect T and B cell dependent gene transcription . ^^^ Lastly , HPK 1 will phosphorylate Crk and CrkL , in vitro , which presents a novel possibility for the regulation of adaptor proteins and downstream signaling events . . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| Combined treatment with siRNAs to Crk and CrkL , which bind to the p130cas substrate domain , inhibited cell spreading by 54 % . ^^^ Both p130cas siRNA and the combined Crk / CrkL siRNAs strongly inhibited ( 52 and 46 % inhibition , respectively ) Caco 2 sheet migration on collagen 4 and noticeably inhibited lamellipodial extension , whereas paxillin siRNA only inhibited migration by 18 % and did not noticeably affect lamellipodial extension . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| This leads to increased phosphorylation of CRK and CRKL , inhibiting these cytoskeletal regulators by promoting intramolecular over intermolecular associations . ^^^ |
|
| Interacting proteins: P46109 and P46108 |
Pubmed |
SVM Score :0.0 |
| CRKL ( CRK Like ) lies within 22q11 . 21 , and Crkl / mice have phenotypic features of 22q11 deletion ( del22q11 ) syndromes . ^^^ Since Fgf 8 signals via receptor type tyrosine kinases , and Crk family adaptor proteins transduce intracellular signals downstream of tyrosine kinases , we investigated whether Crkl mediates Fgf 8 signaling . ^^^ |
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