| Interacting proteins: P29597 and P46109 |
Pubmed |
SVM Score :0.5559784 |
| Such phosphorylation is most likely regulated by the Type 1 interferon receptor ( IFNR ) associated Tyk 2 kinase , as suggested by the detection of Type 1 IFN dependent tyrosine kinase activity in anti CrkL immunoprecipitates and the IFNalpha dependent association of CrkL with Tyk 2 in intact cells . 0.5559784^^^ |
|
| Interacting proteins: P29597 and P46109 |
Pubmed |
SVM Score :0.0 |
| We report that Stat 5 interacts constitutively with the IFN receptor associated Tyk 2 kinase , and during IFNalpha stimulation its tyrosine phosphorylated form acts as a docking site for the SH 2 domain of CrkL . ^^^ |
|
| Interacting proteins: P29597 and P46109 |
Pubmed |
SVM Score :0.0 |
| We also demonstrate that both the Tyk 2 and Jak 1 kinases are required for activation of the CrkL / Rap1 pathway , as the Type 1 IFN dependent GTP bound form of Rap 1 is inhibited by overexpression of dominant negative Tyk 2 or Jak 1 mutants and is defective in cells lacking Tyk 2 or Jak 1 . ^^^ |
|