| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.9756165 |
| It was further revealed that CrkL is recruited to the tyrosine phosphorylated EpoR , most likely through its interaction with tyrosine phosphorylated Shc and SHP 2 . 0.9756165^^^ |
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| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.89456832 |
| We previously demonstrated that , in Epo stimulated cells , an adapter protein , CrkL , becomes tyrosine phosphorylated , physically associates with Shc , SHP 2 , and Cbl , and plays a role in activation of the Ras / Erk signaling pathway . 0.89456832^^^ |
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| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.0 |
| HGF stimulated Gab 1 association with c Met , Grb 2 , SHP 2 , PI3K , Shc , Crk isoforms and CrkL , but not with PLCgamma 1 . ^^^ |
|
| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.0 |
| EGF stimulation also induced the association of Cbl with Src homology and collagen ( Shc ) protein , p 85 subunit of the phosphatidylinositol 3 kinase and Crk proteins , in particular with the CrkL isoform . ^^^ |
|
| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.0 |
| The major target proteins have been identified , and are very similar to the known substrates of BCR / ABL , including Shc , CBL , CRKL , and several proteins in the cytoskeleton . ^^^ |
|
| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.0 |
| CBL interactions with other phosphoproteins , among them SHC and CRKL , were also augmented in response to pretreatment with the PTPase inhibitors . ^^^ |
|
| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.0 |
| The tetramerization domain deleted BCR ABL did not induce tyrosine phosphorylation of CrkL , SHP 2 , Vav and the interactions of BCR ABL and Shc . ^^^ |
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| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of a number of substrates such as GAP , GRB 2 , SHC , FES , CRKL , and paxillin is considered a decisive step in transformation . ^^^ |
|
| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.0 |
| The insulin receptor substrate ( IRS ) , SHC , GRB 2 , CRKII and CRKL adaptor proteins have all been implicated in transmitting signals to the nucleus of the cell . ^^^ |
|
| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.0 |
| These results suggest a fundamental role for the tyrosine phosphorylation of Cbl , CrkL , SLP 76 , and Shc and the association of Cbl with CrkL , SLP 76 , and Nck in Fc gammaRI signaling in human macrophages . ^^^ |
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| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.0 |
| Here we show that this attenuation of tyrosine phosphorylation of Shc , CrkL , and the proto oncogene Cbl is mimicked by treatment of mouse T lymphocytes or cultured Jurkat cells with phorbol 12 myristate 13 acetate . ^^^ |
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| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.0 |
| Our results provide the first evidence that FcalphaR mediated signals modulate a multimolecular adaptor protein complex containing Grb 2 , Shc , SHIP , CrkL , Cbl , and SLP 76 . ^^^ Stimulation of FcalphaRI induced the tyrosine phosphorylation of Shc and increased the association of Grb 2 with Shc and CrkL . ^^^ These data indicate that the stimulation of FcalphaR results in the modulation of adaptor complexes containing tyrosine phosphorylated Cbl , Shc , SHIP , Grb 2 , and Crkl . ^^^ |
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| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.0 |
| To detect phosphorylation dependent interactions of Gab 1 with downstream substrates , we developed a modified yeast two hybrid assay and identified PI ( 3 ) K , Shc , Shp 2 , and CRKL as interaction partners of Gab 1 . ^^^ In a trk met Gab 1 specific branching morphogenesis assay , association of Gab 1 with Shp 2 , but not PI ( 3 ) K , CRKL , or Shc was essential to induce a biological response in MDCK cells . ^^^ |
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| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.0 |
| In addition , Tec and Lyn were shown to phosphorylate Dok 1 , whereas phosphorylated Dok 1 was demonstrated to bind to the SH 2 domains of several signaling molecules activated by SCF , including Abl , CrkL , SHIP , and PLCgamma 1 , but not those of Vav and Shc . ^^^ |
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| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.0 |
| CD 2 crosslinking markedly induced tyrosine phosphorylation of Cbl associated with Grb 2 or CrkL , Shc and LAT , compared with IL 2 stimulation . ^^^ However , costimulation of IL 2 with CD 2 crosslinking remarkably enhanced associations of Grb 2 Shc and CrkL Cbl , compared to IL 2 stimulation or CD 2 crosslinking alone . ^^^ In vitro binding studies using GST fusion proteins revealed that interactions of Grb 2 Shc and CrkL Cbl were mediated through each SH 2 domain in tyrosine phosphorylation dependent manner . ^^^ |
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| Interacting proteins: P46109 and P29353 |
Pubmed |
SVM Score :0.0 |
| We demonstrate here that cross linking of alpha4beta1 by anti alpha 4 antibody induces tyrosine phosphorylation of Pyk 2 , Shc , and Cbl as well as binding of the adaptor protein CrkL with Cbl in a murine hematopoietic cell line , 32D / EpoR Wt . ^^^ |
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