| Because p 85 ( PI3K ) is known to bind to the activated c Kit receptor , the possibility that CRKL interacted with c Kit indirectly through p 85 ( PI3K ) was investigated . 0.933842^^^ Activation of c Kit is shown here to induce tyrosine phosphorylation of CRKL , and CRKL coprecipitated with c Kit through an interaction that required the CRKL SH 3 domains and not the SH 2 domain . 0.66264468^^^ |