| In a search for factors that regulate TTF 1 transcriptional activity , we isolated three genes ( T : G mismatch specific thymine DNA glycosylase ( TDG ) , homeodomain interacting protein kinase 2 ( HIPK 2 ) , and Ajuba ) , whose products can interact with TTF 1 in yeast and in mammalian cells . ^^^ In the present paper , we show that TDG acts as a strong repressor of TTF 1 transcriptional activity in a dose dependent manner , while HIPK 2 and Ajuba display no effect on TTF 1 activity , at least under the tested conditions . ^^^ |