| Interacting proteins: Q9BZM3 and P43699 |
Pubmed |
SVM Score :0.0 |
| In addition , in situ hybridizations were used to define expression patterns of the Dlx 2 and Nkx 2 . 1 homeobox genes in Gsh 2 mutant mice . ^^^ |
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| Interacting proteins: Q9BZM3 and P43699 |
Pubmed |
SVM Score :0.0 |
| Vertebrate genes closely related to vnd ( Nkx2 . 1 and Nkx2 . 2 ) , ind ( Gsh 1 and Gsh 2 ) , and msh ( Msx 1 and Msx 3 ) are expressed in corresponding ventral , intermediate , and dorsal domains during vertebrate neurogenesis , raising the possibility that dorsoventral patterning within the central nervous system is evolutionarily conserved . . ^^^ |
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| Interacting proteins: Q9BZM3 and P43699 |
Pubmed |
SVM Score :0.0 |
| Notably , in animals carrying either of these genetic backgrounds , genes such as Gsh 2 and Dlx 2 , which are expressed pan ventrally , as well as Nkx2 . 1 , which demarcates the ventral most aspect of the telencephalon , appear to be largely restored to their wild type patterns of expression . ^^^ |
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| Interacting proteins: Q9BZM3 and P43699 |
Pubmed |
SVM Score :0.0 |
| Combinatorial function of the homeodomain proteins Nkx2 . 1 and Gsh 2 in ventral telencephalic patterning . ^^^ Regional patterning of the mammalian telencephalon requires the function of three homeodomain containing transcription factors , Pax 6 , Gsh 2 and Nkx2 . 1 . ^^^ Surprisingly , despite the fact that , at specific times in development , both Pax 6 and Gsh 2 maintain a complementary pattern of expression with Nkx2 . 1 , in neither case are these boundaries maintained through a similar cross repressive mechanism . ^^^ Rather , as revealed by analysis of double mutant mice , Nkx2 . 1 and Gsh 2 act cooperatively in many aspects to pattern the ventral telencephalon . ^^^ By contrast , as indicated by both loss and gain of function analysis , Gsh 2 expression in the medial ganglionic eminence after E10 . 5 may negatively regulate Nkx2 . 1 dependent specification of oligodendrocytes . ^^^ |
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| Interacting proteins: Q9BZM3 and P43699 |
Pubmed |
SVM Score :0.0 |
| In addition , activation of canonical Wnt signaling in the subpallium leads to a repression of ventral telencephalic cell identities as shown by the down regulation of subpallial markers Dlx 2 , Nkx2 . 1 , Gsh 2 , Olig 2 and Mash 1 . ^^^ |
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| Interacting proteins: Q9BZM3 and P43699 |
Pubmed |
SVM Score :0.0 |
| The results obtained from quantitative gene expression analysis of region specific genes ( Emx 1 , Lhx 2 , Ngn 1 , Ngn 2 , Pax 6 , Dlx 2 , Gsh 2 , Mash 1 , and Nkx2 . 1 ) , using real time polymerase chain reaction indicate that FACS of GM 1 expressing cells in the fetal forebrain enriches for the medial pallial neural progenitor cells . . ^^^ |
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