| Interacting proteins: Q92908 and P43699 |
Pubmed |
SVM Score :1.2664969 |
| Whereas GATA 6 did not directly alter expression of sp C constructs in HeLa cells , GATA 6 synergistically activated sp C gene transcription when co expressed with TTF 1 , supporting the concept that GATA 6 and TTF 1 might directly interact to influence target gene expression . 1.2664969^^^ Interactions between TTF 1 and GATA 6 required the amino terminal and zinc finger domains of GATA 6 . 0.68598698^^^ GST GATA 6 directly co precipitated with TTF 1 after in vitro translation and directly interacted with the TTF 1 binding element in the sp C promoter . 0.5422897^^^ |
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| Interacting proteins: Q92908 and P43699 |
Pubmed |
SVM Score :0.0 |
| GATA 6 activates transcription of thyroid transcription factor 1 . ^^^ In the present work , GATA 6 mRNA was detected in adult mouse lung , purified mouse type 2 epithelial cells , and differentiated mouse pulmonary adenocarcinoma cells ( MLE 15 cells ) , being co expressed with TTF 1 mRNA . ^^^ GATA 6 , but not GATA 5 , markedly activated TTF 1 gene transcription in HeLa cells . ^^^ EMSA and supershift analysis with GATA 6 antiserum demonstrated that GATA 6 in MLE 15 cell nuclear extracts bound to an element located 96 101 base pairs from major start of TTF 1 gene transcription . ^^^ Site directed mutagenesis of the GATA element in the TTF 1 promoter region inhibited transactivation by GATA 6 in HeLa cells . ^^^ |
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| Interacting proteins: Q92908 and P43699 |
Pubmed |
SVM Score :0.0 |
| Transactivation of the wild type SP A constructs by GATA 6 increased transcriptional activity 7 10 fold , whereas thyroid transcription factor 1 ( TTF 1 ) increased the activity of these constructs 12 18 fold . ^^^ The effects of cotransactivating with both GATA 6 and TTF 1 expression constructs were additive . ^^^ However , mutation of the TTF 1 binding sites alone or in combination decreased GATA 6 transactivation . ^^^ |
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| Interacting proteins: Q92908 and P43699 |
Pubmed |
SVM Score :0.0 |
| The WNT7b promoter is regulated by TTF 1 , GATA 6 , and Foxa 2 in lung epithelium . ^^^ This region of the WNT7b promoter contains several DNA binding sites for the important lung restricted transcription factors TTF 1 , GATA 6 , and Foxa 2 . ^^^ Electrophoretic mobility shift assays showed that TTF 1 , GATA 6 , and Foxa 2 can bind to a specific subset of their consensus DNA binding sites within the WNT7b promoter . ^^^ Using cotransfection assays , we demonstrate that TTF 1 , GATA 6 , and Foxa 2 can trans activate the WNT7b promoter in NIH 3T3 cells . ^^^ Finally , the minimal 118 bp region of the mouse WNT7b promoter containing only TTF 1 binding sites was synergistically activated by TTF 1 and GATA 6 , and we show that TTF 1 and GATA 6 physically interact in vivo . ^^^ |
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| Interacting proteins: Q92908 and P43699 |
Pubmed |
SVM Score :0.0 |
| Homogeneous distribution of the thyroid transcription factor 1 , decreased expression of surfactant proteins , delayed thinning of the walls of the peripheral airways , and lack of squamous differentiation of epithelial cells were observed in the lung periphery after expression of GATA 6 engrailed . ^^^ |
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| Interacting proteins: Q92908 and P43699 |
Pubmed |
SVM Score :0.0 |
| Pulmonary well differentiated fetal adenocarcinoma expressing lineage specific transcription factors ( TTF 1 and GATA 6 ) to respiratory epithelial differentiation : an immunohistochemical and ultrastructural study . ^^^ A case of pulmonary well differentiated fetal adenocarcinoma was examined with conventional histological , immunohistochemical , and ultrastructural studies that revealed the distribution of lineage specific transcription factors ( TTF 1 and GATA 6 ) . ^^^ |
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| Interacting proteins: Q92908 and P43699 |
Pubmed |
SVM Score :0.0 |
| High levels of surfactant protein C ( Sp C ) , thyroid transcription factor 1 ( Ttf 1 ) , and Gata 6 , but not Sp A or Sp B in the epithelium at birth suggested that in these lungs differentiation was arrested at an early stage . ^^^ |
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| Interacting proteins: Q92908 and P43699 |
Pubmed |
SVM Score :0.0 |
| We also investigated gene expression of the transcription factors PCNA , TTF 1 , HNF3beta , GATA 6 , C / EBPalpha and C / EBPdelta which drive , at least in part , development and differentiation of alveolar epithelium . ^^^ |
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| Interacting proteins: Q92908 and P43699 |
Pubmed |
SVM Score :0.0 |
| Hop functions downstream of Nkx2 . 1 and GATA 6 to mediate HDAC dependent negative regulation of pulmonary gene expression . ^^^ Hop functions in the developing pulmonary airway , acting downstream of Nkx2 . 1 and GATA 6 , to negatively regulate surfactant protein expression . ^^^ |
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| Interacting proteins: Q92908 and P43699 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q92908 and P43699 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92908 and P43699 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92908 and P43699 |
Pubmed |
SVM Score :0.0 |
| NA |
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