| Interacting proteins: P43631 and P10321 |
Pubmed |
SVM Score :0.0 |
| Cross linking of the p 58 NK receptor , involved in the recognition of HLA C alleles , delivers a negative signal that prevents target cell lysis . ^^^ |
|
| Interacting proteins: P43631 and P10321 |
Pubmed |
SVM Score :0.0 |
| Much attention has been focused on the NK cell receptors CD158a ( EB 6 ) and CD158b ( GI 183 ) , which recognize two alternative epitopes on the HLA Cw locus . ^^^ |
|
| Interacting proteins: P43631 and P10321 |
Pubmed |
SVM Score :0.0 |
| Expression of HLA C specific natural killer cell receptors ( CD158a and CD158b ) on peripheral blood mononuclear cells after allogeneic bone marrow transplantation . ^^^ |
|
| Interacting proteins: P43631 and P10321 |
Pubmed |
SVM Score :0.0 |
| Sequential analysis of HLA C specific killer cell inhibitory receptor ( CD158b ) expressing peripheral blood mononuclear cells during chronic graft versus host disease . ^^^ We have sequentially investigated the expression of natural killer cell inhibitory receptors ( KIRs ) for HLA C ( CD158b ) on peripheral blood mononuclear cells ( PBMC ) in three patients with extensive chronic graft versus host disease ( cGVHD ) after allogeneic bone marrow transplantation ( alloBMT ) . ^^^ |
|
| Interacting proteins: P43631 and P10321 |
Pubmed |
SVM Score :0.0 |
| The expression rates of CD158a , CD158b and CD 94 on T cells and NK cell were detected by flow cytometry and donor / recipient HLA Cw was analyzed using PCR after peripheral blood stem cell transplantation ( PBSCT ) and umbilical cord blood transplantation ( UCBT ) . ^^^ |
|
| Interacting proteins: P43631 and P10321 |
Pubmed |
SVM Score :0.0 |
| RESULTS : When the interaction between NK cell inhibitory receptors ( i . e . , CD158a , CD158b , and CD159a ) and MHC class 1 molecules ( i . e . , HLA C and HLA E ) on HIV infected autologous T cells was blocked , a drastic increase in killing of anti gp 120 coated HIV infected cells by NK cells was observed . ^^^ |
|
| Interacting proteins: P43631 and P10321 |
Pubmed |
SVM Score :0.0 |
| Substitution of tyrosine 45 with the phenylalanine conserved in other KIR was sufficient to permit specific binding of KIR2DS2 to HLA C . ^^^ |
|
| Interacting proteins: P43631 and P10321 |
Pubmed |
SVM Score :0.0 |
| In contrast , KIR2DS2 was absent in patients more often ( 38 . 0 % vs 25 . 9 % ) when the presumptive HLA C ( Asn 80 ) ligands were present . ^^^ |
|
| Interacting proteins: P43631 and P10321 |
Pubmed |
SVM Score :0.0 |
| Functional studies have identified two distinct p 58 KIR , each reactive with a different group of HLA C allotypes , and distinct p 70 KIR specific for some HLA B or HLA A allotypes . ^^^ |
|
| Interacting proteins: P43631 and P10321 |
Pubmed |
SVM Score :0.0 |
| Native gel shift assay revealed that p 58 KIR K 6 and KIR K 7 bind both HLA Cw 3 and HLA Cw 6 molecules , but p 50 KAR K 1 binds neither of the HLA C molecules . ^^^ However , binding of HLA C molecule by p 58 KIR is affected by the antigenic peptide bound on the MHC molecule , suggesting that the p 58 KIR binding to the HLA C molecule may be dependent on the peptide . ^^^ In addition , the binding interaction requires the presence of both p 58 Ig domains , suggesting that the binding mode of HLA C and p 58 KIR may have some similarity to that of the neonatal Fc receptor and the Fc fragment of Ab and may be distinct from that of TCR and MHC . . ^^^ |
|
| Interacting proteins: P43631 and P10321 |
Pubmed |
SVM Score :0.0 |
| Diversity of the repertoire of p 58 killer cell inhibitory receptors in a single individual . p 58 Killer cell inhibitory receptors ( KIRs ) recognize HLA C molecules on target cell surface and transmit an inhibitory signal to prevent cell mediated cytotoxicity . p 58 KIR family is composed of multiple receptors whose amino acid sequences are similar but their ligand specificity is different . ^^^ |
|
| Interacting proteins: P43631 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43631 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43631 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43631 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43631 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43631 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43631 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43631 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43631 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43631 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P43631 and P10321 |
Pubmed |
SVM Score :0.0 |
| NA |
|