| Nontranscriptional regulation of SYK by the coactivator OCA B is required at multiple stages of B cell development . ^^^ This study has shown that OCA B also functions in the pre B 1 to pre B 2 cell transition and , most surprisingly , that it directly interacts with SYK , a tyrosine kinase critical for pre BCR and BCR signaling . ^^^ This study indicates that OCA B is required for pre BCR and BCR signaling at multiple stages of B cell development through its nontranscriptional regulation of SYK . ^^^ |