| Interacting proteins: Q13191 and P43405 |
Pubmed |
SVM Score :0.6814912 |
| In heterogeneous COS 1 cells , Cbl b was phosphorylated on tyrosine residues by both Syk ( Syk / Zap 70 ) and Src ( Fyn / Lck ) family kinases , with Syk kinase inducing the most prominent effect . 0.6814912^^^ |
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| Interacting proteins: Q13191 and P43405 |
Pubmed |
SVM Score :0.0 |
| Cbl b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk . ^^^ In B cells from Cbl b deficient mice cross linking the BCRs resulted in sustained phosphorylation of Igalpha , Syk , and phospholipase C ( PLC ) gamma 2 , leading to prolonged Ca2+ mobilization , and increases in extracellular signal regulated kinase ( ERK ) and c Jun NH 2 terminal protein kinase ( JNK ) phosphorylation and surface expression of the activation marker , CD 69 . ^^^ Image analysis following BCR cross linking showed sustained polarization of the BCRs into large signaling active caps associated with phosphorylated Syk in Cbl b deficient B cells in contrast to the BCRs in Cbl b expressing B cells that rapidly proceeded to form small , condensed , signaling inactive caps . ^^^ Significantly , prolonged phosphorylation of Syk correlated with reduced ubiquitination of Syk indicating that Cbl b negatively regulates BCR signaling by targeting Syk for ubiquitination . . ^^^ |
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| Interacting proteins: Q13191 and P43405 |
Pubmed |
SVM Score :0.0 |
| The antigen induced tyrosine phosphorylation of FcepsilonRI , Syk , phospholipase C gamma ( PLC gamma ) , activation of c Jun N terminal kinase ( JNK ) , extracellular signal regulated kinase ( ERK ) , inhibitor of nuclear factor kappaB kinase ( IKK ) , and Ca++ influx were all suppressed in the cells overexpressing Cbl b in the lipid raft . ^^^ These results suggest that Cbl b is a negative regulator of both Lyn Syk LAT and Gab2mediated complementary signaling pathways in FcepsilonRI mediated mast cell activation . . ^^^ |
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| Interacting proteins: Q13191 and P43405 |
Pubmed |
SVM Score :0.0 |
| FcepsilonRI mediated tyrosine phosphorylation of Syk , Gab 2 , and phospholipase C gamma 1 , and activation of c Jun N terminal kinase ( JNK ) , extracellular signal regulated kinase ( ERK ) , p 38 mitogen activated protein kinase ( MAP kinase ) , and inhibitor of nuclear factor kappaB kinase ( IKK ) , and generation of Rac 1 are unaffected in cells overexpressing the truncated Cbl b in the lipid raft . ^^^ |
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| Interacting proteins: Q13191 and P43405 |
Pubmed |
SVM Score :0.0 |
| Here we further report that stimulation with GM CSF causes phosphorylation of Syk protein kinase , but neither Casitas B lineage lymphoma ( Cbl ) nor Cbl b in CD 34 ( + ) hemopoietic progenitors can be blocked by anti CD 116 mAb . ^^^ Thus , GM CSF binds to its receptor CD 116 , and consequently activates Syk phosphorylation , which leads to induce CXCR 3 expression . gamma IP 10 and Mig can induce Syk , Cbl , and Cbl b phosphorylation in CD 34 ( + ) progenitors by means of CXCR 3 . gamma IP 10 or Mig has induced neither chemotaxis nor adhesion in GM CSF stimulated Cbl b blocked CD 34 ( + ) hemopoietic progenitors , whereas SDF 1alpha induces both chemotaxis and adhesion in these cells . ^^^ Thus , Cbl b , but not Syk and Cbl phosphorylation , is essential for gamma IP 10 and Mig induced chemotaxis and adhesion in CD 34 ( + ) hemopoietic progenitors . ^^^ |
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| Interacting proteins: Q13191 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13191 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13191 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
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