| Interacting proteins: P42229 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42229 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42229 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42229 and P43405 |
Pubmed |
SVM Score :0.0 |
| We first observed that in the absence of Jak 3 , both Lck and Syk had the capacity to phosphorylate Stat 3 and Stat5a . ^^^ |
|
| Interacting proteins: P42229 and P43405 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we report that signaling mediated by IL 15 binding to the newly identified IL 15R alpha isoforms involves the phosphorylation of STAT 3 , STAT 5 , STAT 6 , Janus kinase 2 , and Syk kinase . ^^^ |
|
| Interacting proteins: P42229 and P43405 |
Pubmed |
SVM Score :0.0 |
| TEL Syk fusion constitutively activates PI 3 K / Akt , MAPK and JAK 2 independent STAT 5 signal pathways . ^^^ TEL Syk also activated the signal transducer and activator of transcription 5 ( STAT 5 ) in the absence of Janus kinase 2 activation . ^^^ These data suggest that TEL Syk fusion protein in the cytoplasm leads to the constitutive activation of PI 3 K / Akt , MAPK and STAT 5 signal pathways , which are closely involved in IL 3 independent cell proliferation of BaF 3 cells . . ^^^ |
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