| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylated forms of Ig beta , CD 22 , TCR zeta and HOSS are major ligands for tandem SH 2 domains of Syk . ^^^ |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| IgM , CD 22 , Ig alpha , Ig beta , and Syk were coimmunoprecipitated with CD 19 from detergent lysates of B lymphocytes . ^^^ |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| Among the targets of mIg induced tyrosine phosphorylation are the tyrosine kinases encoded by the lyn , blk , fyn , and syk genes , the mIg associated proteins MB 1 and Ig beta , phospholipase C gamma 1 and gamma 2 , as well as many unidentified proteins . ^^^ |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| A possible explanation for this requirement was provided by findings that recruitment of Syk to tyrosine phosphorylated immunoglobulin ( Ig ) alpha and Ig beta requires both Syk SH 2 domains . ^^^ These findings not only confirm that both SH 2 domains are necessary for Syk binding to tyrosine phosphorylated Ig alpha and Ig beta but indicate that this binding is necessary for Syk ( Y518 / 519 ) phosphorylation after BCR ligation . ^^^ |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| Syk activity gradually increased to a maximum at 10 30 min following receptor ligation and was found to parallel the association of Syk with the tyrosine phosphorylated Ig alpha and Ig beta subunits of the receptor . ^^^ |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| Syk protein tyrosine kinase is regulated by tyrosine phosphorylated Ig alpha / Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation . ^^^ Syk activation in B cells correlates with Syk tyrosine phosphorylation as well as with Syk SH 2 mediated association with the tyrosine phosphorylated Ig alpha and Ig beta B cell antigen receptor subunits . ^^^ Tyrosine phosphorylated peptide 20 mers representing Ig alpha and Ig beta immunoreceptor tyrosine activation motifs were synthesized and found to stimulate the specific activity of Syk by as much as 10 fold in vitro . ^^^ Our observations suggest the association of Syk tandem SH 2 domains with the tyrosine phosphorylated Ig alpha and / or Ig beta immunoreceptor tyrosine activation motifs in B cells stimulates Syk autophosphorylation leading to Syk enzyme activation . . ^^^ |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| In addition , we demonstrate that both ZAP 70 and Syk can bind directly to the phosphorylated Ig alpha and Ig beta subunits with affinities comparable to their binding to the TCR CD 3 epsilon subunit . ^^^ |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| Of the tyrosine kinases transfected ( Lyn , Blk , Hck , Syk , Fyn ) , only Blk was able to phosphorylate and subsequently associate with cotransfected Ig alpha and Ig beta chimeras in vivo . ^^^ |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| Furthermore , at least 25 % of phosphorylated p40 / 42 co immunoprecipitated with Ig alphabeta , but none precipitated with MHC 2 , CD 40 , Fc ( gamma ) RII , Fyn , HS 1 , or Syk , suggesting that this protein complex specifically associates with the Ig alphabeta heterodimer . p40 / 42 did not react with Abs to Ig alpha , Ig beta , mitogen activated protein kinase , or Lnk . ^^^ |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| Semi quantitative RT PCR analysis performed on mononuclear bone marrow cells from the non XLA patient indicated that lambda like , VpreB , Rag 1 , Rag 2 and TdT transcripts expressed during proB cell stages were found at normal levels whereas E2A , CD 10 , Syk , Pax 5 , CD 19 , Ig alpha , Ig beta , VH C mu and 5 kappa C kappa transcripts characteristic of later stages were severely depressed . ^^^ |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| The cross linking of Ig beta on proB cells freshly isolated from bone marrow of recombination activating gene ( RAG ) 2 deficient mice induced a rapid and transient tyrosine phosphorylation of Ig alpha as well as an array of intracellular proteins including Syk , PI 3 kinase , Vav , and SLP 76 . ^^^ |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| Coligation of the cytoplasmic region of PD 1 with the B cell receptor ( BCR ) in IIA1 . 6 transformants inhibited BCR mediated growth retardation , Ca ( 2+ ) mobilization , and tyrosine phosphorylation of effector molecules , including Ig beta , Syk , phospholipase C gamma 2 ( PLC gamma 2 ) , and ERK1 / 2 , whereas phosphorylation of Lyn and Dok was not affected . ^^^ |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| Following B cell antigen receptor ( BCR ) ligation , the cytoplasmic domains of immunoglobulin alpha ( Ig alpha ) and Ig beta recruit Syk to initiate signaling cascades . ^^^ |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| Semiquantitative RT PCR analysis performed on mononuclear bone marrow cells indicated that lambda like , VpreB , Rag 1 , Rag 2 , and TdT transcripts expressed during proB cell stages were found at normal levels whereas E2A , CD 10 , Syk , Pax 5 , CD 19 , Igalpha , Igbeta , VH Cmu , and Vkappa Ckappa transcripts characteristic of later stages were severely depressed . ^^^ |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| ER 27319 did not inhibit the tyrosine phosphorylation of Syk induced by activation in the presence of Igbeta ITAM or the anti IgM induced phosphorylation of Syk in human peripheral B cells . ^^^ |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| These events promoted Lyn activation and Igbeta phosphorylation and led to the generation of a raft associated signaling module composed of tyrosine phosphorylated Lyn , Syk , BLNK , PI3K , Btk , VAV , and PLCgamma 2 . ^^^ |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| B cell Ag receptor ( BCR ) signaling occurs via tyrosine phosphorylation of CD79a and CD79b ITAMs , leading to recruitment and activation of Lyn and Syk tyrosine kinases and subsequent downstream events . ^^^ In both CD45+ and CD 45 cells , Ag stimulation led to CD79a and CD79b tyrosine phosphorylation as well as Syk tyrosine phosphorylation , recruitment to the receptors , and activation . ^^^ Surprisingly , in view of previous findings implicating Src family kinases in ITAM phosphorylation , the data indicate that Ag induced CD79a and CD79b tyrosine phosphorylation and Syk recruitment and activation can occur in the absence of CD 45 expression and , hence , Src family kinase activation . . ^^^ |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| We assessed the expression and methylation status of CD 19 , CD 20 , CD79B , SYK , PU . 1 , BOB . 1 / OBF . 1 , BCMA , and LCK , all of which are typically down regulated in cHL . ^^^ Using methylation specific polymerase chain reaction ( MSP ) , bisulfite genomic sequencing , and digestion with methylation sensitive endonuclease followed by polymerase chain reaction ( PCR ) , we determined the methylation status of promoter regions of PU . 1 , BOB . 1 / OBF . 1 , CD 19 , SYK , and CD79B . ^^^ Using bisulfite genomic sequencing we found that in microdissected HRS cells of primary cHL SYK , BOB . 1 / OBF . 1 , and CD79B promoters were also hypermethylated . ^^^ |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P40259 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|