| Interacting proteins: P23458 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P23458 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23458 and P43405 |
Pubmed |
SVM Score :0.0 |
| To date , the kinases Jak 1 , Jak 2 , Tyk 2 , Lyn , and Syk have been implicated in this process . ^^^ |
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| Interacting proteins: P23458 and P43405 |
Pubmed |
SVM Score :0.0 |
| In fact , at least four protein tyrosine kinases ( PTKs ) are physically associated with IL 2R : p56lck ( and its members ) , Syk PTK , and the Janus kinases , Jak 1 and Jak 3 . cDNA expression studies revealed that the activation of these PTKs is critical for IL 2 induced proliferative signal transmission . ^^^ |
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| Interacting proteins: P23458 and P43405 |
Pubmed |
SVM Score :0.0 |
| Several tyrosine kinases such as Jak 1 , Jak 3 , Lck and Syk are known to participate in IL 2 mediated intracellular signal transduction . ^^^ Jak 1 , Lck and Syk are associated with the cytoplasmic domain of the beta chain , whereas Jak 3 is associated with the cytoplasmic domain of the gamma chain , which is shared among receptors for IL 2 , IL 4 , IL 7 and IL 15 . ^^^ |
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| Interacting proteins: P23458 and P43405 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the lead dimethoxyquinazoline compound , WHI P 131 , which showed potent JAK 3 inhibitory activity ( IC 50 of 78 microM ) , did not inhibit JAK 1 and JAK 2 , the ZAP / SYK family tyrosine kinase SYK , the TEC family tyrosine kinase BTK , the SRC family tyrosine kinase LYN , or the receptor family tyrosine kinase insulin receptor kinase , even at concentrations as high as 350 microM . ^^^ |
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| Interacting proteins: P23458 and P43405 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that erythroid progenitor cells express several receptor and non receptor tyrosine kinases , like c kit , Jak 1 , Ryk , FAK , Syk , Arg , Csk and members of the insulin receptor family . ^^^ |
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| Interacting proteins: P23458 and P43405 |
Pubmed |
SVM Score :0.0 |
| Even at very high concentrations ranging from 175 350 microM , this inhibitor did not affect the enzymatic activity of other PTKs , including the Janus kinases JAK 1 and JAK 3 , the Src family kinase HCK , the Tec family member Bruton ' s tyrosine kinase , SYK kinase , and the receptor family PTK insulin receptor kinase . ^^^ |
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| Interacting proteins: P23458 and P43405 |
Pubmed |
SVM Score :0.0 |
| Interestingly , Syk functioned as a direct substrate of Jak 1 but not Jak 3 . ^^^ Jak 3 may regulate Syk catalytic activity indirectly via Jak 1 . ^^^ While the essential roles of Jak 1 and Jak 3 in signaling by gammac utilizing cytokines are clear , it will be important to dissect the exact contributions of Lck and Syk in mediating the effects of IL 2 and related cytokines . . ^^^ |
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| Interacting proteins: P23458 and P43405 |
Pubmed |
SVM Score :0.0 |
| Of particular interest is WHI P 131 , which inhibits JAK 3 but not JAK 1 , JAK 2 , SYK , BTK , LYN , or IRK at concentrations as high as 350 microM . ^^^ |
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| Interacting proteins: P23458 and P43405 |
Pubmed |
SVM Score :0.0 |
| According to the known functions of their genes , the clusters were designated as proliferating cell ( CDC 42 , TOP2A , FGFR 3 , MYC , etc . ) , neoangiogenesis and blood cell ( LCK , VAV 1 , KDR , VEGF , MMP 9 , SYK , PTPRS , and FLT 4 ) , invasion 1 and invasion 2 ( ADAM 17 , TRPM 2 , DUSP 6 , VIM , CAV 1 , CAV 2 , JAK 1 , PTPNS 1 , FYN , and PDGFB ) , HER 2 , and PSA / PSM / HER3 . ^^^ |
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| Interacting proteins: P23458 and P43405 |
Pubmed |
SVM Score :0.0 |
| The experiments with KI mutants for various tyrosine kinases revealed that c Src and Pyk 2 ( but not JAK 1 , Jak 2 , Syk , and Tec ) are involved in ET 1 induced upregulation of Bcl xL expression . ^^^ |
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