| Interacting proteins: P15391 and P43405 |
Pubmed |
SVM Score :0.0 |
| Detailed analysis of the early signaling events showed that compared with muF ( ab ) 2 fragments CD 19 bispecific antibodies potently raised the intracellular [ Ca2+ ] , which was correlated with an efficient tyrosine phosphorylation of syk . ^^^ |
|
| Interacting proteins: P15391 and P43405 |
Pubmed |
SVM Score :0.0 |
| Semiquantitative RT PCR analysis performed on mononuclear bone marrow cells indicated that lambda like , VpreB , Rag 1 , Rag 2 , and TdT transcripts expressed during proB cell stages were found at normal levels whereas E2A , CD 10 , Syk , Pax 5 , CD 19 , Igalpha , Igbeta , VH Cmu , and Vkappa Ckappa transcripts characteristic of later stages were severely depressed . ^^^ |
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| Interacting proteins: P15391 and P43405 |
Pubmed |
SVM Score :0.0 |
| PKC mu activity is up regulated after cross linking the BCR and CD 19 on B cells , and PKC mu co precipitates with Syk and phospholipase C gamma 1 / 2 ( PLC gamma 1 / 2 ) . ^^^ |
|
| Interacting proteins: P15391 and P43405 |
Pubmed |
SVM Score :0.0 |
| We suggest that the basis for phosphorylation is the association of CD 19 with Syk and other components of the mIgM complex . ^^^ IgM , CD 22 , Ig alpha , Ig beta , and Syk were coimmunoprecipitated with CD 19 from detergent lysates of B lymphocytes . ^^^ |
|
| Interacting proteins: P15391 and P43405 |
Pubmed |
SVM Score :0.0 |
| Semi quantitative RT PCR analysis performed on mononuclear bone marrow cells from the non XLA patient indicated that lambda like , VpreB , Rag 1 , Rag 2 and TdT transcripts expressed during proB cell stages were found at normal levels whereas E2A , CD 10 , Syk , Pax 5 , CD 19 , Ig alpha , Ig beta , VH C mu and 5 kappa C kappa transcripts characteristic of later stages were severely depressed . ^^^ |
|
| Interacting proteins: P15391 and P43405 |
Pubmed |
SVM Score :0.0 |
| Co cross linking of CD 72 and CD 19 failed to induce syk tyrosine phosphorylation suggesting that even under these conditions , CD 72 signaling was independent of syk activation . ^^^ |
|
| Interacting proteins: P15391 and P43405 |
Pubmed |
SVM Score :0.0 |
| Using a CD 19 reconstituted myeloma model and CD 19 gene ablated animals we found that BCR mediated Btk activation and phosphorylation are dependent on the expression of CD 19 , while BCR mediated activation of Lyn and Syk is not . ^^^ |
|
| Interacting proteins: P15391 and P43405 |
Pubmed |
SVM Score :0.0 |
| Whereas CD 19 does not appear to be involved in this SYK dependent pathway , the SYK substrate CBL is likely involved as the dominant negative SYK markedly attenuates CBL tyrosine phosphorylation and completely blocks the BCR dependent association of CBL with p 85 PI3K . . ^^^ |
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| Interacting proteins: P15391 and P43405 |
Pubmed |
SVM Score :0.0 |
| Here we report that leukemic cells from pediatric CD 19 ( + ) CD 10 ( ) pro B cell ALL patients ( but not leukemic cells from patients with CD 19 ( + ) CD 10 ( + ) common pre pre B cell ALL ) have markedly reduced SYK activity . ^^^ In contrast to pro B leukemia cells , pre pre B leukemia cells from children with CD 19 ( + ) CD 10 ( + ) common B lineage ALL and EBV transformed B cell lines from healthy volunteers expressed wild type Syk coding sequences . ^^^ |
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| Interacting proteins: P15391 and P43405 |
Pubmed |
SVM Score :0.0 |
| FcgammaRIIA ligation in RS 4 ; 11 and 380 cells induced tyrosine phosphorylation of CD 32 , CD 19 , CBL , SYK , P 13 K p 85 and SHIP , as well as RasGAP association with tyrosine phosphorylated p 62 ( dok ) . ^^^ |
|
| Interacting proteins: P15391 and P43405 |
Pubmed |
SVM Score :0.0 |
| These regulatory functions of activated CR 2 were specific as independent of syk tyrosine kinase and of CD 19 and BCR activation . ^^^ |
|
| Interacting proteins: P15391 and P43405 |
Pubmed |
SVM Score :0.0 |
| We assessed the expression and methylation status of CD 19 , CD 20 , CD79B , SYK , PU . 1 , BOB . 1 / OBF . 1 , BCMA , and LCK , all of which are typically down regulated in cHL . ^^^ Using methylation specific polymerase chain reaction ( MSP ) , bisulfite genomic sequencing , and digestion with methylation sensitive endonuclease followed by polymerase chain reaction ( PCR ) , we determined the methylation status of promoter regions of PU . 1 , BOB . 1 / OBF . 1 , CD 19 , SYK , and CD79B . ^^^ |
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| Interacting proteins: P15391 and P43405 |
Pubmed |
SVM Score :0.0 |
| By contrast , CD19 / CD21 ligation using higher concentrations of SA C3dg significantly inhibited BCR induced [ Ca2+ ] 1 responses and inhibited CD 19 , Lyn , CD 22 , and Syk phosphorylation . ^^^ |
|
| Interacting proteins: P15391 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15391 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|