| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| Although some details remain to be elucidated , signaling following crosslinking of Fc gamma RIIA requires the activation of tyrosine kinases of both Src family kinases and Syk , resulting in tyrosine phosphorylation of Shc , phospholipase C gamma isozymes , and a [ Ca2+ ] 1 transient . ^^^ |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| PAO also inhibited completely tyrosine phosphorylation of PLC gamma 2 in collagen and Fc gamma RIIA stimulated cells , although tyrosine phosphorylation of other proteins including the tyrosine kinase syk was relatively unaffected . ^^^ |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| The action of Syk is less pronounced on the phagocytic Fc gamma RII receptor , Fc gamma RIIA , which does not require the gamma chain for phagocytosis . ^^^ |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| Generation of endogenous oxidants in PMN by cross linking Fc gamma RIIIb similarly enhanced phosphorylation of Fc gamma RIIa and Syk , a tyrosine kinase required for phagocytic function , in a catalase sensitive manner . ^^^ |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| The tyrosine kinase Syk associates with the cytoplasmic domain of both the Fc gamma receptor gamma chain and Fc gamma RIIA and is required for phagocytosis by both Fc gamma receptor systems . ^^^ To elucidate the differences in phagocytic signaling by the gamma chain and Fc gamma RIIA , we investigated the requirements for Fc gamma receptor / Syk co immunoprecipitation , tyrosine phosphorylation , and phagocytosis . ^^^ Our data also indicate that the two ITAM tyrosines of the human gamma chain and Fc gamma RIIA do not contribute equally to Fc gamma receptor association with Syk kinase and phagocytic signaling . ^^^ |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| In contrast to IgG Fc receptor 2 ( Fc gamma RIIa ) , the function of Src family kinases , Syk and phosphoinositide 3 kinase ( PI3K ) in signal transduction of glycosylphosphatidylinositol anchored Fc gamma RIIIb has not been analyzed in detail . ^^^ |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| Using synthetic phosphopeptides , and stable transfectants expressing immunoreceptor tyrosine based activation motif ( ITAM ) tyrosine mutants of Fc gamma RIIa , we demonstrate that SHP 1 associates with the phosphorylated amino terminal ITAM tyrosine of Fc gamma RIIa , whereas the tyrosine kinase Syk associates with the carboxyl terminal ITAM tyrosine . ^^^ Furthermore , Fc gamma RIIa clustering results in the association of SHP 1 with key signaling molecules such as Syk , p 85 subunit of PtdIns 3 kinase , and p62dok , suggesting that these molecules may be substrates of SHP 1 in this system . ^^^ |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| However , antibody stimulation was dependent on co stimulation of the FcgammaII receptor ( CD 32 ) since specific F ( ab ' ) 2 fragments did not induce Syk and PLCgamma 2 phosphorylation . ^^^ |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| FcgammaRIIA ligation in RS 4 ; 11 and 380 cells induced tyrosine phosphorylation of CD 32 , CD 19 , CBL , SYK , P 13 K p 85 and SHIP , as well as RasGAP association with tyrosine phosphorylated p 62 ( dok ) . ^^^ |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we detected tyrosine kinase activity and the presence of the tyrosine kinase Syk in association with CD 32 in the soluble hypertonic lysis fraction . ^^^ This fraction also contained most of the tyrosine phosphorylated proteins including Cbl , Syk and CD 32 itself . ^^^ |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12318 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|