| Interacting proteins: P09769 and P43405 |
Pubmed |
SVM Score :0.0 |
| The photodynamic inhibitory effect of hypericin and a number of hypericin derivatives were investigated in vitro using numerous growth factor regulated protein kinases including receptor bound ( Insulin R , EGF R ) and non receptor ( Lyn , c Fgr , CSK , Syk ) protein tyrosine kinases as well as Ser / Thr ( PK C , protein kinase CK 2 , CK 1 ) protein kinases . ^^^ |
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| Interacting proteins: P09769 and P43405 |
Pubmed |
SVM Score :0.0 |
| Formation of protein complexes containing Src family kinases and p 72 ( syk ) required PMN spreading because p 72 ( syk ) was not detected in p 58 ( c fgr ) or p53 / 56 ( lyn ) immunoprecipitates from PMN , which were stimulated with TNF alpha , in suspension . ^^^ |
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| Interacting proteins: P09769 and P43405 |
Pubmed |
SVM Score :0.0 |
| Hematopoietic lineage cell specific HS 1 protein is converted into a substrate for c Fgr by previous Syk mediated phosphorylation , at site ( s ) that bind to the SH 2 domain of c Fgr [ Ruzzene , M . , Brunati , A . ^^^ Stimulation of c Fgr catalytic activity is also promoted by the full length HS 1 protein , previously tyrosine phosphorylated by Syk , and is accounted for by an increased Vmax while the Km values are unchanged . ^^^ Interestingly , neither Syk and C terminal Src kinase nor three other members of the Src family ( Lyn , Lck , and Fyn ) are susceptible to stimulation by phosphopeptide , as observed with c Fgr . ^^^ |
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| Interacting proteins: P09769 and P43405 |
Pubmed |
SVM Score :0.0 |
| Incubation of neutrophils on surface bound anti beta 2 subunit antibodies induced a very rapid ( within 1 min ) redistribution of the cytoskeletal proteins talin , alpha actinin , and paxillin , and the tyrosine kinases p 58 ( c fgr ) , p53 / 56 ( lyn ) , and p 72 ( syk ) to a cell fraction insoluble in Triton 10 100 . ^^^ |
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| Interacting proteins: P09769 and P43405 |
Pubmed |
SVM Score :0.0 |
| The GST CT became phosphorylated in the presence of Lyn , Hck and Syk ( immunoprecipitated from human neutrophils ) , but not in the presence of Fgr . ^^^ |
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| Interacting proteins: P09769 and P43405 |
Pubmed |
SVM Score :0.0 |
| Macrophages derived from mice deficient for the three members of the Src family of kinases expressed in these cells , Hck , Fgr , and Lyn , exhibited poor Syk activation upon FcgammaR engagement , accompanied by a delay in FcgammaR mediated phagocytosis . ^^^ |
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| Interacting proteins: P09769 and P43405 |
Pubmed |
SVM Score :0.0 |
| This interaction is not mediated by the src kinases Lyn and Fgr , since neither kinase coprecipitated with Syk . ^^^ |
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| Interacting proteins: P09769 and P43405 |
Pubmed |
SVM Score :0.0 |
| These molecules include three distinct classes of tyrosine kinases , Syk , FAK , and Fgr , and the functionally diverse proteins Vav and paxillin . . ^^^ |
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| Interacting proteins: P09769 and P43405 |
Pubmed |
SVM Score :0.0 |
| Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr . ^^^ Whereas the Syk tyrosine kinase is essential for beta 2 integrin signaling and cell spreading , the Src family kinase Fgr is a negative regulator of this pathway . ^^^ Fgr selectively inhibits beta 2 but not beta 1 integrin signaling and Syk kinase function via a direct association between the Fgr SH 2 domain and Syk tyrosine Y 342 . ^^^ |
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| Interacting proteins: P09769 and P43405 |
Pubmed |
SVM Score :0.0 |
| In this report we show that both wild type and hck ( / ) fgr ( / ) macrophages expressed Fyn , Src , and Yes and that these kinases were activated on ingestion of immunoglobulin G ( IgG ) coated particles and redistributed , together with Syk , to actin rich phagocytic cups and the phagosomal membrane . ^^^ |
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| Interacting proteins: P09769 and P43405 |
Pubmed |
SVM Score :0.0 |
| Fgr but not Syk tyrosine kinase is a target for beta 2 integrin induced c Cbl mediated ubiquitination in adherent human neutrophils . ^^^ The following observations imply that Syk is such a kinase : ( 1 ) beta ( 2 ) integrins activated Syk in a Src dependent manner , ( 2 ) Syk was associated with Cbl much longer than Fgr was , and ( 3 ) the Syk inhibitor piceatannol ( 3 , 4 , 3 ' , 5 ' tetrahydroxy trans stilbene ) abolished the Cbl associated kinase activity in an in vitro assay . ^^^ In contrast with Fgr , Syk was not modified by the E 3 ligase . ^^^ Thus Cbl appears to be essential in beta ( 2 ) integrin signalling , first by serving as a matrix for a subsequent agonist induced signalling interaction between Fgr and Syk , and then by mediating ubiquitination of Fgr which possibly affects its interaction with Cbl . . ^^^ |
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| Interacting proteins: P09769 and P43405 |
Pubmed |
SVM Score :0.0 |
| Activation of chemokine receptors can trigger JAK STAT pathway , Lck , Fyn , Lyn , Fgr , and Syk / Zap 70 to induce chemotaxis of inflammatory cells . ^^^ |
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| Interacting proteins: P09769 and P43405 |
Pubmed |
SVM Score :0.0 |
| Six of the seven were a fusion of TEL with protein tyrosine kinase , LYN , HCK , FGR , SYK , FLT 3 , and TYK 2 . ^^^ |
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| Interacting proteins: P09769 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09769 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09769 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09769 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09769 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09769 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09769 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09769 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09769 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09769 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09769 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09769 and P43405 |
Pubmed |
SVM Score :0.0 |
| NA |
|